MCID: SPN017
MIFTS: 32

Spindle Cell Liposarcoma malady

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Spindle Cell Liposarcoma

Aliases & Descriptions for Spindle Cell Liposarcoma:

Name: Spindle Cell Liposarcoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5705
NCIt 47 C27489
SNOMED-CT 64 404073009
UMLS 69 C1275275

Summaries for Spindle Cell Liposarcoma

MalaCards based summary : Spindle Cell Liposarcoma is related to fibrosarcoma and rommen mueller sybert syndrome. An important gene associated with Spindle Cell Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Hematopoietic cell lineage. The drugs Doxorubicin and Miconazole have been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Spindle Cell Liposarcoma

Diseases related to Spindle Cell Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
id Related Disease Score Top Affiliating Genes
1 fibrosarcoma 29.2 CD34 CREB3L2 HBA1 KIT MYOD1 SMARCB1
2 rommen mueller sybert syndrome 10.4 CDK4 MDM2
3 primary eye hypotony 10.3 CDK4 MDM2
4 osteomyelitis 10.3 CDK4 MDM2
5 idiopathic cd4-positive t-lymphocytopenia 10.3 CR2 SMARCB1
6 conjunctival disease 10.3 MYOD1 WT1
7 blood protein disease 10.3 CDK4 MDM2
8 cervical large cell neuroendocrine carcinoma 10.3 HBA1 WT1
9 ectopic pregnancy 10.3 HBA1 MYOD1
10 liposarcoma 10.3
11 extraosseous osteosarcoma 10.3 CDK4 MDM2 MYOD1
12 pleomorphic adenoma 10.3 CD34 HBA1
13 basophil adenoma 10.3 CD34 HBA1
14 mixed type rhabdomyosarcoma 10.3 MYOD1 MYOG
15 sarcocystosis 10.2 CD34 HBA1
16 dermoid cyst 10.2 CD34 HBA1
17 thyroid angiosarcoma 10.2 CD34 HBA1
18 cervix endometrial stromal tumor 10.2 CD34 HBA1
19 vulvar dystrophy 10.2 CD34 HBA1
20 botryoid rhabdomyosarcoma 10.2 KIT MYOD1
21 lung benign neoplasm 10.2 MYOD1 SMARCB1 WT1
22 breast juvenile papillomatosis 10.2 CD34 HBA1
23 thymus lipoma 10.2 CALB2 WT1
24 choriocarcinoma 10.2 KIT WT1
25 hemopneumothorax 10.2 CD34 HBA1
26 episodic ataxia 10.2 CD34 CDK4 MDM2
27 lymphatic system disease 10.2 CALB2 SMARCB1
28 brain stem angioblastoma 10.2 CD34 CDK4 MDM2
29 heel spur 10.2 CD34 SMARCB1
30 superior vena cava angiosarcoma 10.2 CD34 HBA1
31 acantholytic squamous cell skin carcinoma 10.2 CD34 CREB3L2
32 cloacogenic carcinoma 10.2 CR2 HBA1
33 neurofibroma of gallbladder 10.2 CD34 KIT
34 gallbladder leiomyosarcoma 10.2 CD34 KIT
35 apocrine sweat gland neoplasm 10.2 CDK4 MDM2
36 ossifying fibromyxoid tumor 10.2 CD34 CDK4 HBA1
37 speech disorder 10.2 CD34 KIT
38 prostate rhabdomyosarcoma 10.2 CDK4 MYOD1 MYOG
39 mediastinum rhabdomyosarcoma 10.2 CDK4 MYOD1 MYOG
40 sarcoma 10.2 CREB3L2 KIT
41 childhood medulloblastoma 10.2 MYOD1 MYOG SMARCB1
42 functionless pituitary adenoma 10.2 CD34 CREB3L2 MDM2
43 bilateral breast cancer 10.2 CD34 CR2 HBA1
44 brain stem infarction 10.2 MYOD1 MYOG WT1
45 leiomyomatosis 10.2 CD34 KIT
46 phencyclidine abuse 10.2 CD34 HBA1 WT1
47 freemartinism 10.2 CD34 KIT
48 spindle cell rhabdomyosarcoma 10.2 MYOD1 MYOG WT1
49 diabetes persistent mullerian ducts 10.1 MYOD1 MYOG WT1
50 laryngeal adenoid cystic carcinoma 10.1 CD34 HBA1

Graphical network of the top 20 diseases related to Spindle Cell Liposarcoma:



Diseases related to Spindle Cell Liposarcoma

Symptoms & Phenotypes for Spindle Cell Liposarcoma

MGI Mouse Phenotypes related to Spindle Cell Liposarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 MDM2 MYOD1 MYOG SMARCB1 WT1 CD34
2 liver/biliary system MP:0005370 9.8 CDK4 DDIT3 KIT MDM2 SMARCB1 WT1
3 muscle MP:0005369 9.8 CDK4 KIT MDM2 MYOD1 MYOG SMARCB1
4 neoplasm MP:0002006 9.76 CD34 CDK4 DDIT3 KIT MDM2 MYOD1
5 no phenotypic analysis MP:0003012 9.43 KIT MDM2 MLANA MYOD1 MYOG WT1
6 normal MP:0002873 9.17 CALB2 CDK4 KIT MDM2 MYOD1 MYOG

Drugs & Therapeutics for Spindle Cell Liposarcoma

Drugs for Spindle Cell Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
2
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
3
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
4
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
5
Doxil Approved June 1999 Phase 1, Phase 2 31703
6 Topoisomerase Inhibitors Phase 1, Phase 2
7 Anti-Bacterial Agents Phase 1, Phase 2
8 Anti-Infective Agents Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2
10 Antifungal Agents Phase 1, Phase 2
11 Antibiotics, Antitubercular Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Completed NCT00949325 Phase 1, Phase 2

Search NIH Clinical Center for Spindle Cell Liposarcoma

Genetic Tests for Spindle Cell Liposarcoma

Anatomical Context for Spindle Cell Liposarcoma

Publications for Spindle Cell Liposarcoma

Articles related to Spindle Cell Liposarcoma:

(show all 11)
id Title Authors Year
1
A large well-differentiated spindle cell liposarcoma (atypical spindle cell lipomatous tumor): clinicopathologic and immunohistochemical analysis Diagnostic and therapeutic features. ( 25624426 )
2014
2
Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. ( 23887155 )
2013
3
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. ( 23413865 )
2013
4
Spindle cell liposarcoma of the face: case report and literature review. ( 20456346 )
2010
5
Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation. ( 20418237 )
2010
6
Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings. ( 20518903 )
2010
7
Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. ( 20228779 )
2010
8
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. ( 15719245 )
2005
9
Spindle-cell liposarcoma: a rare variant of liposarcoma arising in the foot. ( 15830579 )
2005
10
Images in pathology: multiple cytoplasmic vacuoles in a spindle cell liposarcoma. ( 12232576 )
2002
11
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. ( 8067512 )
1994

Variations for Spindle Cell Liposarcoma

Expression for Spindle Cell Liposarcoma

Search GEO for disease gene expression data for Spindle Cell Liposarcoma.

Pathways for Spindle Cell Liposarcoma

Pathways related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.2 CDK4 CREB3L2 KIT MDM2
2 11.48 CD34 CR2 KIT
3 11.32 CD34 KIT MYOD1
4 11.08 MDM2 MYOD1 SMARCB1
5 10.91 CD34 KIT MYOD1 MYOG
6 10.86 CD34 CR2 KIT

GO Terms for Spindle Cell Liposarcoma

Cellular components related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 CDK4 CREB3L2 DDIT3 MDM2 MYOD1 MYOG

Biological processes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.71 CD34 KIT MDM2 TLE1
2 positive regulation of transcription, DNA-templated GO:0045893 9.65 CREB3L2 DDIT3 MYOD1 MYOG WT1
3 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.63 CREB3L2 DDIT3 MYOD1 MYOG SMARCB1 WT1
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.54 DDIT3 KIT SMARCB1
5 positive regulation of myoblast differentiation GO:0045663 9.51 MYOD1 MYOG
6 negative regulation of cell cycle arrest GO:0071157 9.49 CDK4 MDM2
7 positive regulation of myoblast fusion GO:1901741 9.48 MYOD1 MYOG
8 myoblast differentiation GO:0045445 9.46 MYOD1 MYOG
9 mRNA transcription from RNA polymerase II promoter GO:0042789 9.43 DDIT3 MYOG
10 myotube differentiation GO:0014902 9.32 MYOD1 MYOG
11 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
12 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.56 CD34 DDIT3 MYOD1 TLE1
2 sequence-specific DNA binding GO:0043565 9.55 CREB3L2 DDIT3 MYOD1 MYOG WT1
3 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.26 CREB3L2 DDIT3 MYOG WT1
4 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.02 CREB3L2 DDIT3 MYOD1 MYOG SMARCB1

Sources for Spindle Cell Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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