MCID: SPN017
MIFTS: 31

Spindle Cell Liposarcoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Spindle Cell Liposarcoma

MalaCards integrated aliases for Spindle Cell Liposarcoma:

Name: Spindle Cell Liposarcoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5705
NCIt 47 C27489
SNOMED-CT 64 404073009
UMLS 69 C1275275

Summaries for Spindle Cell Liposarcoma

MalaCards based summary : Spindle Cell Liposarcoma is related to rnase t2-deficient leukoencephalopathy and reactive arthritis. An important gene associated with Spindle Cell Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Hematopoietic cell lineage and C-MYB transcription factor network. The drugs Doxorubicin and Everolimus have been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Spindle Cell Liposarcoma

Diseases related to Spindle Cell Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
id Related Disease Score Top Affiliating Genes
1 rnase t2-deficient leukoencephalopathy 10.9 CDK4 MDM2
2 reactive arthritis 10.8 CDK4 MDM2
3 primary eye hypotony 10.8 MDM2 SMARCB1
4 transitional cell carcinoma 10.8 MDM2 MYOD1
5 metachronous osteosarcoma of the bone 10.8 CDK4 MDM2
6 bile duct rhabdomyosarcoma 10.8 KIT MYOD1
7 lipoic acid biosynthesis defects 10.7 CDK4 MDM2
8 adult pineoblastoma 10.7 HBA1 WT1
9 epithelioid trophoblastic tumor 10.7 KIT WT1
10 botryoid rhabdomyosarcoma 10.7 KIT MYOD1
11 lung benign neoplasm 10.7 SMARCB1 WT1
12 localized osteosarcoma 10.7 CDK4 MDM2 MYOD1
13 rectum leiomyoma 10.7 CR2 HBA1
14 sarcoma 10.6 CREB3L2 KIT
15 wilms tumor 6 10.6 KIT WT1
16 bile duct sarcoma 10.6 MYOD1 MYOG
17 dysgraphia 10.6 CD34 HBA1
18 neurofibroma 10.6 CD34 HBA1
19 appendix leiomyoma 10.6 CD34 KIT
20 small intestine leiomyosarcoma 10.6 CD34 KIT
21 conventional angiosarcoma 10.6 CD34 HBA1
22 pleomorphic adenoma 10.6 CD34 HBA1
23 vulvar dystrophy 10.6 CD34 HBA1
24 liver inflammatory pseudotumor 10.6 CD34 KIT
25 dermoid cyst 10.6 CD34 HBA1
26 vestibule of mouth cancer 10.6 CD34 CR2
27 cerebrum cancer 10.5 MYOD1 SMARCB1 WT1
28 juxtacortical chondrosarcoma 10.5 CDK4 MDM2
29 cervical adenoma malignum 10.5 CD34 HBA1
30 anus leiomyoma 10.5 CD34 KIT
31 heel spur 10.5 CD34 SMARCB1
32 filamentary keratitis 10.5 CD34 KIT
33 cervical endometrial stromal sarcoma 10.5 CD34 HBA1
34 malignant dermis tumor 10.5 CD34 KIT
35 gallbladder leiomyosarcoma 10.5 CD34 KIT
36 gastric cardia adenocarcinoma 10.5 CR2 KIT MDM2
37 salivary gland adenoid cystic carcinoma 10.5 CD34 HBA1
38 breast epithelioid hemangioma 10.5 CDK4 MDM2
39 hemopneumothorax 10.5 CD34 HBA1
40 breast leiomyosarcoma 10.5 CD34 KIT
41 gingival hypertrophy 10.5 MLANA WT1
42 uveal melanoma 10.5 MLANA WT1
43 endodermal sinus tumor 10.5 CREB3L2 MDM2 MYOD1
44 mixed extragonadal germ cell cancer 10.5 CR2 KIT MDM2
45 pericoronitis 10.5 CD34 KIT
46 skin lipoma 10.5 CD34 CDK4 MDM2
47 fallopian tube squamous cell carcinoma 10.5 CD34 KIT
48 neurofibroma of the esophagus 10.5 CD34 CDK4 MDM2
49 teeth hard tissue disease 10.5 HBA1 MLANA
50 granular cell leiomyosarcoma 10.4 MYOD1 MYOG

Graphical network of the top 20 diseases related to Spindle Cell Liposarcoma:



Diseases related to Spindle Cell Liposarcoma

Symptoms & Phenotypes for Spindle Cell Liposarcoma

MGI Mouse Phenotypes related to Spindle Cell Liposarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CD34 CDK4 CR2 DDIT3 KIT MDM2
2 liver/biliary system MP:0005370 9.8 CDK4 DDIT3 KIT MDM2 SMARCB1 WT1
3 muscle MP:0005369 9.8 CDK4 KIT MDM2 MYOD1 MYOG SMARCB1
4 neoplasm MP:0002006 9.76 MYOD1 SMARCB1 WT1 CD34 CDK4 DDIT3
5 no phenotypic analysis MP:0003012 9.43 KIT MDM2 MLANA MYOD1 MYOG WT1
6 normal MP:0002873 9.17 KIT MDM2 MYOD1 MYOG WT1 CALB2

Drugs & Therapeutics for Spindle Cell Liposarcoma

Drugs for Spindle Cell Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
2
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
5
Doxil Approved June 1999 Phase 1, Phase 2 31703
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Antibiotics, Antitubercular Phase 1, Phase 2
8 Antifungal Agents Phase 1, Phase 2
9 Anti-Infective Agents Phase 1, Phase 2
10 Immunosuppressive Agents Phase 1, Phase 2
11 Topoisomerase Inhibitors Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Completed NCT00949325 Phase 1, Phase 2 temsirolimus (Torisel) plus liposomal doxorubicin (Doxil)

Search NIH Clinical Center for Spindle Cell Liposarcoma

Genetic Tests for Spindle Cell Liposarcoma

Anatomical Context for Spindle Cell Liposarcoma

Publications for Spindle Cell Liposarcoma

Articles related to Spindle Cell Liposarcoma:

(show all 11)
id Title Authors Year
1
A large well-differentiated spindle cell liposarcoma (atypical spindle cell lipomatous tumor): clinicopathologic and immunohistochemical analysis Diagnostic and therapeutic features. ( 25624426 )
2014
2
Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. ( 23887155 )
2013
3
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. ( 23413865 )
2013
4
Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation. ( 20418237 )
2010
5
Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings. ( 20518903 )
2010
6
Spindle cell liposarcoma of the face: case report and literature review. ( 20456346 )
2010
7
Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. ( 20228779 )
2010
8
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. ( 15719245 )
2005
9
Spindle-cell liposarcoma: a rare variant of liposarcoma arising in the foot. ( 15830579 )
2005
10
Images in pathology: multiple cytoplasmic vacuoles in a spindle cell liposarcoma. ( 12232576 )
2002
11
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. ( 8067512 )
1994

Variations for Spindle Cell Liposarcoma

Expression for Spindle Cell Liposarcoma

Search GEO for disease gene expression data for Spindle Cell Liposarcoma.

Pathways for Spindle Cell Liposarcoma

Pathways related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.48 CD34 CR2 KIT
2 11.32 CD34 KIT MYOD1
3 11.08 MDM2 MYOD1 SMARCB1
4 10.91 CD34 KIT MYOD1 MYOG
5 10.86 CD34 CR2 KIT

GO Terms for Spindle Cell Liposarcoma

Cellular components related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 CDK4 CREB3L2 DDIT3 MDM2 MYOD1 MYOG

Biological processes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 CD34 KIT MDM2 TLE1
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.73 CREB3L2 DDIT3 MYOD1 MYOG SMARCB1 WT1
3 positive regulation of transcription, DNA-templated GO:0045893 9.55 CREB3L2 DDIT3 MYOD1 MYOG WT1
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.54 DDIT3 KIT SMARCB1
5 negative regulation of cell cycle arrest GO:0071157 9.51 CDK4 MDM2
6 myoblast differentiation GO:0045445 9.48 MYOD1 MYOG
7 positive regulation of myoblast differentiation GO:0045663 9.46 MYOD1 MYOG
8 positive regulation of myoblast fusion GO:1901741 9.43 MYOD1 MYOG
9 mRNA transcription from RNA polymerase II promoter GO:0042789 9.4 DDIT3 MYOG
10 myotube differentiation GO:0014902 9.32 MYOD1 MYOG
11 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
12 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.46 CD34 DDIT3 MYOD1 TLE1
2 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.26 CREB3L2 DDIT3 MYOG WT1
3 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.02 CREB3L2 DDIT3 MYOD1 MYOG SMARCB1

Sources for Spindle Cell Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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