MCID: SPN009
MIFTS: 29

Spindle Cell Rhabdomyosarcoma malady

Cancer diseases category
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Summaries for Spindle Cell Rhabdomyosarcoma

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33MalaCards
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MalaCards: Spindle Cell Rhabdomyosarcoma is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Spindle Cell Rhabdomyosarcoma is DES (desmin), and among its related pathways are L1CAM interactions and Immune response Function of MEF2 in T lymphocytes. The compounds dihydrotestosterone and triiodothyronine have been mentioned in the context of this disorder. Affiliated tissues include prostate and tongue.

Aliases & Classifications for Spindle Cell Rhabdomyosarcoma

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8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell rhabdomyosarcoma 8 62


External Ids:

Disease Ontology8 DOID:3260
NCIt40 C6519

Related Diseases for Spindle Cell Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Spindle Cell Rhabdomyosarcoma:



Diseases related to spindle cell rhabdomyosarcoma

Symptoms for Spindle Cell Rhabdomyosarcoma

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Drugs & Therapeutics for Spindle Cell Rhabdomyosarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Spindle Cell Rhabdomyosarcoma

Genetic Tests for Spindle Cell Rhabdomyosarcoma

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Anatomical Context for Spindle Cell Rhabdomyosarcoma

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33MalaCards
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MalaCards organs/tissues related to Spindle Cell Rhabdomyosarcoma:

33
Prostate, Tongue

Animal Models for Spindle Cell Rhabdomyosarcoma or affiliated genes

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Publications for Spindle Cell Rhabdomyosarcoma

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52PubMed
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Articles related to Spindle Cell Rhabdomyosarcoma:

(show all 23)
idTitleAuthorsYear
1
Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. (24272621)
2014
2
Spindle cell rhabdomyosarcoma of the neck with t(6;8) translocation: report of a case and literature review. (23113671)
2013
3
Spindle cell rhabdomyosarcoma of the prostate. (23320845)
2013
4
Spindle cell rhabdomyosarcoma displaying CD34 positivity: a potential diagnostic pitfall; report of two pediatric cases. (24022313)
2013
5
Spindle cell rhabdomyosarcoma: a brief diagnostic review and differential diagnosis. (23899074)
2013
6
Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. (23463663)
2013
7
Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. (20518428)
2010
8
Aggressive spindle cell rhabdomyosarcoma in an 11-month-old boxer dog. (20460837)
2010
9
Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature. (19017660)
2010
10
Unique case of giant adult paratesticular spindle cell rhabdomyosarcoma. (19036416)
2009
11
Radiation-induced mandibular adult spindle cell rhabdomyosarcoma. (18023143)
2008
12
Clinicopathologic analysis of spindle cell rhabdomyosarcoma: report of 8 cases]. (18646700)
2008
13
Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy. (16860492)
2006
14
Spindle cell rhabdomyosarcoma in adults. (16006807)
2005
15
Paratesticular spindle cell rhabdomyosarcoma diagnosed by fine needle aspiration cytology: a case report. (15966299)
2005
16
Spindle cell rhabdomyosarcoma of the tongue in an infant: a case report with emphasis on differential diagnosis of childhood spindle cell lesions. (15462501)
2004
17
Spindle-cell rhabdomyosarcoma with 2q36 approximately q37 involvement. (12550761)
2003
18
Paratesticular spindle cell rhabdomyosarcoma in an adult. (11458081)
2001
19
Spindle cell rhabdomyosarcoma in adults. A case report and literature review. (10674275)
2000
20
Cytogenetic study of a spindle-cell rhabdomyosarcoma of the parotid gland. (10087951)
1999
21
Spindle cell rhabdomyosarcoma (so-called) in adults: report of two cases with emphasis on differential diagnosis. (9537474)
1998
22
Spindle cell rhabdomyosarcoma: histologic variant of embryonal rhabdomyosarcoma with association to favorable prognosis. (7882713)
1995
23
Spindle cell rhabdomyosarcoma. A prognostically favorable variant of rhabdomyosarcoma. (1599014)
1992

Variations for Spindle Cell Rhabdomyosarcoma

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Expression for genes affiliated with Spindle Cell Rhabdomyosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Rhabdomyosarcoma

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Pathways for genes affiliated with Spindle Cell Rhabdomyosarcoma

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Sources:
50PathCards, 55Reactome, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1NCOA2, MYOD1
2
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
9.1NCOA2, MYOD1
39.1NCOA2, MYOD1

Compounds for genes affiliated with Spindle Cell Rhabdomyosarcoma

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience, 3BitterDB, 51PharmGKB
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Compounds related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone45 29 24 1112.6DES, NCOA2
2triiodothyronine459.4NCOA2, MYOD1
3lactacystin459.4MYOD1, NCOA2
4estradiol45 24 1111.4NCOA2, DES
5mg 13245 6110.4MYOD1, NCOA2
6progesterone45 29 61 24 1113.3NCOA2, DES
7azathioprine45 3 51 1112.3DES, MYOD1
8bromodeoxyuridine459.3MYOD1, DES
912-o-tetradecanoylphorbol 13-acetate459.2MYOD1, DES
10acetylcholine45 51 29 24 1113.2DES, MYOD1
11actinomycin d459.1MYOD1, DES
12paraffin459.0DES, MYOD1
13fatty acid458.9MYOD1, DES
14lysine458.9NCOA2, MYOD1, DES
15cyclic amp45 249.9NCOA2, MYOD1, DES
16testosterone45 61 24 1111.9DES, MYOD1, NCOA2
17steroid458.8NCOA2, MYOD1, DES
18arginine458.8DES, MYOD1, NCOA2
19estrogen458.8NCOA2, MYOD1, DES
20retinoic acid45 249.8DES, MYOD1, NCOA2
21glucose458.8NCOA2, MYOD1, DES
22creatinine458.7MYOD1, DES
23tyrosine458.7NCOA2, MYOD1, DES

GO Terms for genes affiliated with Spindle Cell Rhabdomyosarcoma

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16Gene Ontology
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Molecular functions related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription coactivator activityGO:0037139.1NCOA2, MYOD1
2nuclear hormone receptor bindingGO:0352578.8NCOA2, MYOD1

Products for genes affiliated with Spindle Cell Rhabdomyosarcoma

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  • Antibodies
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Sources for Spindle Cell Rhabdomyosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet