MCID: SPN009
MIFTS: 29

Spindle Cell Rhabdomyosarcoma malady

Cancer diseases category

Summaries for Spindle Cell Rhabdomyosarcoma

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34MalaCards
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MalaCards: Spindle Cell Rhabdomyosarcoma is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Spindle Cell Rhabdomyosarcoma is DES (desmin), and among its related pathways are L1CAM interactions and Immune response Function of MEF2 in T lymphocytes. The compounds dihydrotestosterone and triiodothyronine have been mentioned in the context of this disorder. Affiliated tissues include prostate and tongue.

Aliases & Classifications for Spindle Cell Rhabdomyosarcoma

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Sources:
9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell rhabdomyosarcoma 9 63


External Ids:

Disease Ontology9 DOID:3260
NCIt41 C6519

Related Diseases for Spindle Cell Rhabdomyosarcoma

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18GeneCards, 19GeneDecks
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Graphical network of diseases related to Spindle Cell Rhabdomyosarcoma:



Diseases related to spindle cell rhabdomyosarcoma

Symptoms for Spindle Cell Rhabdomyosarcoma

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Drugs & Therapeutics for Spindle Cell Rhabdomyosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Spindle Cell Rhabdomyosarcoma

Drug clinical trials:

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Genetic Tests for Spindle Cell Rhabdomyosarcoma

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Anatomical Context for Spindle Cell Rhabdomyosarcoma

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34MalaCards
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MalaCards organs/tissues related to Spindle Cell Rhabdomyosarcoma:

34
Prostate, Tongue

Animal Models for Spindle Cell Rhabdomyosarcoma or affiliated genes

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Publications for Spindle Cell Rhabdomyosarcoma

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53PubMed
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Articles related to Spindle Cell Rhabdomyosarcoma:

(show all 23)
idTitleAuthorsYear
1
Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. (24272621)
2014
2
Spindle cell rhabdomyosarcoma of the neck with t(6;8) translocation: report of a case and literature review. (23113671)
2013
3
Spindle cell rhabdomyosarcoma of the prostate. (23320845)
2013
4
Spindle cell rhabdomyosarcoma displaying CD34 positivity: a potential diagnostic pitfall; report of two pediatric cases. (24022313)
2013
5
Spindle cell rhabdomyosarcoma: a brief diagnostic review and differential diagnosis. (23899074)
2013
6
Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. (23463663)
2013
7
Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. (20518428)
2010
8
Aggressive spindle cell rhabdomyosarcoma in an 11-month-old boxer dog. (20460837)
2010
9
Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature. (19017660)
2010
10
Unique case of giant adult paratesticular spindle cell rhabdomyosarcoma. (19036416)
2009
11
Radiation-induced mandibular adult spindle cell rhabdomyosarcoma. (18023143)
2008
12
Clinicopathologic analysis of spindle cell rhabdomyosarcoma: report of 8 cases]. (18646700)
2008
13
Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy. (16860492)
2006
14
Spindle cell rhabdomyosarcoma in adults. (16006807)
2005
15
Paratesticular spindle cell rhabdomyosarcoma diagnosed by fine needle aspiration cytology: a case report. (15966299)
2005
16
Spindle cell rhabdomyosarcoma of the tongue in an infant: a case report with emphasis on differential diagnosis of childhood spindle cell lesions. (15462501)
2004
17
Spindle-cell rhabdomyosarcoma with 2q36 approximately q37 involvement. (12550761)
2003
18
Paratesticular spindle cell rhabdomyosarcoma in an adult. (11458081)
2001
19
Spindle cell rhabdomyosarcoma in adults. A case report and literature review. (10674275)
2000
20
Cytogenetic study of a spindle-cell rhabdomyosarcoma of the parotid gland. (10087951)
1999
21
Spindle cell rhabdomyosarcoma (so-called) in adults: report of two cases with emphasis on differential diagnosis. (9537474)
1998
22
Spindle cell rhabdomyosarcoma: histologic variant of embryonal rhabdomyosarcoma with association to favorable prognosis. (7882713)
1995
23
Spindle cell rhabdomyosarcoma. A prognostically favorable variant of rhabdomyosarcoma. (1599014)
1992

Variations for Spindle Cell Rhabdomyosarcoma

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Expression for genes affiliated with Spindle Cell Rhabdomyosarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Rhabdomyosarcoma

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Pathways for genes affiliated with Spindle Cell Rhabdomyosarcoma

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Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1NCOA2, MYOD1
2
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis61
9.1NCOA2, MYOD1
39.1NCOA2, MYOD1

Compounds for genes affiliated with Spindle Cell Rhabdomyosarcoma

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB, 52PharmGKB
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Compounds related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone46 30 25 1212.6DES, NCOA2
2triiodothyronine469.4NCOA2, MYOD1
3lactacystin469.4MYOD1, NCOA2
4estradiol46 25 1211.4NCOA2, DES
5mg 13246 6210.4MYOD1, NCOA2
6progesterone46 30 62 25 1213.3NCOA2, DES
7azathioprine46 3 52 1212.3DES, MYOD1
8bromodeoxyuridine469.3MYOD1, DES
912-o-tetradecanoylphorbol 13-acetate469.2MYOD1, DES
10acetylcholine46 52 30 25 1213.2DES, MYOD1
11actinomycin d469.1MYOD1, DES
12paraffin469.0DES, MYOD1
13fatty acid468.9MYOD1, DES
14lysine468.9NCOA2, MYOD1, DES
15cyclic amp46 259.9NCOA2, MYOD1, DES
16testosterone46 62 25 1211.9DES, MYOD1, NCOA2
17steroid468.8NCOA2, MYOD1, DES
18arginine468.8DES, MYOD1, NCOA2
19estrogen468.8NCOA2, MYOD1, DES
20retinoic acid46 259.8DES, MYOD1, NCOA2
21glucose468.8NCOA2, MYOD1, DES
22creatinine468.7MYOD1, DES
23tyrosine468.7NCOA2, MYOD1, DES

GO Terms for genes affiliated with Spindle Cell Rhabdomyosarcoma

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Sources:
17Gene Ontology
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Molecular functions related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription coactivator activityGO:0037139.1NCOA2, MYOD1
2nuclear hormone receptor bindingGO:0352578.8NCOA2, MYOD1

Products for genes affiliated with Spindle Cell Rhabdomyosarcoma

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  • Antibodies
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Sources for Spindle Cell Rhabdomyosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet