Spindle Cell Rhabdomyosarcoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Spindle Cell Rhabdomyosarcoma

MalaCards based summary: Spindle Cell Rhabdomyosarcoma is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Spindle Cell Rhabdomyosarcoma is DES (desmin), and among its related pathways are L1CAM interactions and Immune response Function of MEF2 in T lymphocytes. The compounds dihydrotestosterone and triiodothyronine have been mentioned in the context of this disorder. Affiliated tissues include prostate and tongue.

Aliases & Classifications for Spindle Cell Rhabdomyosarcoma

Sources:
⁹Disease Ontology, ⁶¹UMLS, ³⁹NCIt, ⁵⁶SNOMED-CT
See all sources

Spindle Cell Rhabdomyosarcoma, Aliases & Descriptions:

Name: Spindle Cell Rhabdomyosarcoma ⁹ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases

External Ids:

Disease Ontology⁹ DOID:3260

SNOMED-CT⁵⁶ 128749008, 404055006

NCIt³⁹ C6519

UMLS⁶¹ C1266134

Related Diseases for Spindle Cell Rhabdomyosarcoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Spindle Cell Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)

id	Related Disease	Score	Top Affiliating Genes
1	rhabdomyosarcoma	31.2	MYOD1, DES
2	embryonal rhabdomyosarcoma	30.5	DES, MYOD1
3	mesenchymal chondrosarcoma	10.4	NCOA2
4	alveolar soft part sarcoma	10.2	MYOD1
5	prostatitis	10.2
6	rhabdoid tumor	10.0	MYOD1, DES
7	alveolar rhabdomyosarcoma	10.0	DES, MYOD1
8	malignant fibroxanthoma	9.9	MYOD1, DES
9	leiomyosarcoma	9.9	MYOD1, DES
10	duchenne muscular dystrophy	9.9	DES, MYOD1
11	malignant mesothelioma	9.9	DES, MYOD1
12	muscular dystrophy	9.9	MYOD1, DES
13	peripheral primitive neuroectodermal tumor	9.9	MYOD1, DES
14	adenoma	9.9	MYOD1, NCOA2
15	wilms tumor	9.8	MYOD1, DES
16	myopathy	9.8	MYOD1, DES
17	sarcoma	9.7	DES, MYOD1

Graphical network of diseases related to Spindle Cell Rhabdomyosarcoma:

Symptoms for Spindle Cell Rhabdomyosarcoma

Drugs & Therapeutics for Spindle Cell Rhabdomyosarcoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Spindle Cell Rhabdomyosarcoma

Search NIH Clinical Center for Spindle Cell Rhabdomyosarcoma

Genetic Tests for Spindle Cell Rhabdomyosarcoma

Anatomical Context for Spindle Cell Rhabdomyosarcoma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Spindle Cell Rhabdomyosarcoma:

³²

Prostate, Tongue

Animal Models for Spindle Cell Rhabdomyosarcoma or affiliated genes

Publications for Spindle Cell Rhabdomyosarcoma

Sources:
⁵¹PubMed
See all sources

Articles related to Spindle Cell Rhabdomyosarcoma:

(show all 26)

id	Title	Authors	Year
1	Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. (24272621)	Szuhai K.... Hogendoorn P.C.	2014
2	An adult spindle cell rhabdomyosarcoma in the head and neck region with long-term survival: a case report. (24946859)	Hartmann S.... MA1ller-Richter U.D.	2014
3	Spindle cell rhabdomyosarcoma in the hypopharynx of an adult. (25197406)	Wu T.T.... Zheng Z.J.	2014
4	Spindle cell rhabdomyosarcoma of the retroperitoneum: an unusual case developed in a pregnant woman but obscured by pregnancy. (25197361)	Yu L.... Yang S.J.	2014
5	Spindle cell rhabdomyosarcoma of the neck with t(6;8) translocation: report of a case and literature review. (23113671)	Mentrikoski M.J.... Legallo R.	2013
6	Spindle cell rhabdomyosarcoma of the prostate. (23320845)	Latz S.... Fechner G.	2013
7	Spindle cell rhabdomyosarcoma displaying CD34 positivity: a potential diagnostic pitfall; report of two pediatric cases. (24022313)	KaAsar A.... DervA+A9oA9lu S.	2013
8	Spindle cell rhabdomyosarcoma: a brief diagnostic review and differential diagnosis. (23899074)	Carroll S.J.... Nodit L.	2013
9	Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. (23463663)	Mosquera J.M.... Antonescu C.R.	2013
10	Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. (20518428)	Daneshbod Y.... Khademi B.	2010
11	Aggressive spindle cell rhabdomyosarcoma in an 11-month-old boxer dog. (20460837)	da Roza M.R.... Miguel M.C.	2010
12	Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature. (19017660)	Gavino A.C.... Peng Y.	2010
13	Unique case of giant adult paratesticular spindle cell rhabdomyosarcoma. (19036416)	Silvestris N.... Colucci G.	2009
14	Radiation-induced mandibular adult spindle cell rhabdomyosarcoma. (18023143)	Goosens V.... Casselman J.	2008
15	Clinicopathologic analysis of spindle cell rhabdomyosarcoma: report of 8 cases]. (18646700)	Zhang H.T.... Su Q.	2008
16	Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy. (16860492)	Diniz G.... Vergin C.	2006
17	Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. (17013628)	Mentzel T.... Kuhnen C.	2006
18	Spindle cell rhabdomyosarcoma in adults. (16006807)	Nascimento A.F.... Fletcher C.D.	2005
19	Paratesticular spindle cell rhabdomyosarcoma diagnosed by fine needle aspiration cytology: a case report. (15966299)	Daneshbod Y.... Rastegar M.	2005
20	Spindle cell rhabdomyosarcoma of the tongue in an infant: a case report with emphasis on differential diagnosis of childhood spindle cell lesions. (15462501)	Gupta A.... Chou P.M.	2004
21	Spindle-cell rhabdomyosarcoma with 2q36 approximately q37 involvement. (12550761)	Debiec-Rychter M.... Sciot R.	2003
22	Paratesticular spindle cell rhabdomyosarcoma in an adult. (11458081)	Kizer W.S.... Schwartz B.F.	2001
23	Spindle cell rhabdomyosarcoma in adults. A case report and literature review. (10674275)	Fernando Val-Bernal J.... GA^mez-RomA!n J.J.	2000
24	Spindle cell rhabdomyosarcoma (so-called) in adults: report of two cases with emphasis on differential diagnosis. (9537474)	Rubin B.P.... Fletcher C.D.	1998
25	Spindle cell rhabdomyosarcoma: histologic variant of embryonal rhabdomyosarcoma with association to favorable prognosis. (7882713)	Leuschner I.	1995
26	Spindle cell rhabdomyosarcoma. A prognostically favorable variant of rhabdomyosarcoma. (1599014)	Cavazzana A.O.... Salviati G.	1992

Genes related to Spindle Cell Rhabdomyosarcoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Spindle Cell Rhabdomyosarcoma:

- Elite gene

id	Symbol	Description	Score	Implication
1	DES	desmin	23.37	GeneCards inferred via : Publications (show sections)
2	MYOD1	myogenic differentiation 1	13.46	GeneCards inferred via : Publications (show sections)
3	NCOA2	nuclear receptor coactivator 2	6.46	GeneCards inferred via : Publications (show sections)

Products for genes related to Spindle Cell Rhabdomyosarcoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	3	-	3	3
2	Novus Biologicals	3	3	3	-

Variations for Spindle Cell Rhabdomyosarcoma

Expression for genes affiliated with Spindle Cell Rhabdomyosarcoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Rhabdomyosarcoma

Search GEO for disease gene expression data for Spindle Cell Rhabdomyosarcoma.

Pathways for genes affiliated with Spindle Cell Rhabdomyosarcoma

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ⁵⁹Thomson Reuters, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	L1CAM interactions⁵⁴ Show member pathways Developmental Biology⁵⁴ CHL1 interactions⁵⁴ Neurofascin interactions⁵⁴ Axon guidance⁵⁴ NrCAM interactions⁵⁴	9.1	NCOA2, MYOD1
2	Immune response Function of MEF2 in T lymphocytes⁵⁹ Show member pathways Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis⁵⁹	9.1	NCOA2, MYOD1
3	Regulation of nuclear SMAD2/3 signaling³⁷	9.1	NCOA2, MYOD1

Compounds for genes affiliated with Spindle Cell Rhabdomyosarcoma

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ²⁵HMDB, ¹²DrugBank, ⁶⁰Tocris Bioscience, ³BitterDB, ⁵⁰PharmGKB
See all sources

Compounds related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 23)

id	Compound	Score	Top Affiliating Genes
1	dihydrotestosterone⁴⁴ ²⁹ ²⁵ ¹²	12.6	DES, NCOA2
2	triiodothyronine⁴⁴	9.4	NCOA2, MYOD1
3	lactacystin⁴⁴	9.4	MYOD1, NCOA2
4	estradiol⁴⁴ ²⁵ ¹²	11.4	NCOA2, DES
5	mg 132⁴⁴ ⁶⁰	10.4	MYOD1, NCOA2
6	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	13.3	NCOA2, DES
7	azathioprine⁴⁴ ³ ⁵⁰ ¹²	12.3	DES, MYOD1
8	bromodeoxyuridine⁴⁴	9.3	MYOD1, DES
9	12-o-tetradecanoylphorbol 13-acetate⁴⁴	9.2	MYOD1, DES
10	acetylcholine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.2	DES, MYOD1
11	actinomycin d⁴⁴	9.1	MYOD1, DES
12	paraffin⁴⁴	9.0	DES, MYOD1
13	fatty acid⁴⁴	8.9	MYOD1, DES
14	lysine⁴⁴	8.9	NCOA2, MYOD1, DES
15	cyclic amp⁴⁴ ²⁵	9.9	NCOA2, MYOD1, DES
16	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.9	DES, MYOD1, NCOA2
17	steroid⁴⁴	8.8	NCOA2, MYOD1, DES
18	arginine⁴⁴	8.8	DES, MYOD1, NCOA2
19	estrogen⁴⁴	8.8	NCOA2, MYOD1, DES
20	retinoic acid⁴⁴ ²⁵	9.8	DES, MYOD1, NCOA2
21	glucose⁴⁴	8.8	NCOA2, MYOD1, DES
22	creatinine⁴⁴	8.7	MYOD1, DES
23	tyrosine⁴⁴	8.7	NCOA2, MYOD1, DES

GO Terms for genes affiliated with Spindle Cell Rhabdomyosarcoma

Sources:
¹⁷Gene Ontology
See all sources

Molecular functions related to Spindle Cell Rhabdomyosarcoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transcription coactivator activity	GO:003713	9.1	NCOA2, MYOD1
2	nuclear hormone receptor binding	GO:035257	8.8	NCOA2, MYOD1

Products for genes affiliated with Spindle Cell Rhabdomyosarcoma

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Spindle Cell Rhabdomyosarcoma

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: SPN009 MIFTS: 29	Spindle Cell Rhabdomyosarcoma malady Cancer diseases category
3 genes, 2 tissues, 17 related diseases, clinical trials Download this MalaCard Expand all tables

Spindle Cell Rhabdomyosarcoma malady