MCID: SPN035
MIFTS: 50

Spindle Cell Sarcoma malady

Cancer category

Summaries for Spindle Cell Sarcoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

MalaCards: Spindle Cell Sarcoma, also known as sarcoma, spindle cell, is related to kaposi's sarcoma and synovial sarcoma. An important gene associated with Spindle Cell Sarcoma is KRT13 (keratin 13), and among its related pathways are miRNAs involved in DDR and PLK3 signaling events. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and heart, and related mouse phenotypes are renal/urinary system and pigmentation.

Disease Ontology:8 A sarcoma that results in cells that are spindle-shaped. they are usually resistant to radiation therapy.

Aliases & Classifications for Spindle Cell Sarcoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

spindle cell sarcoma 8 10
sarcoma, spindle cell 61
sarcoma spindle cell 45


External Ids:

Disease Ontology8 DOID:4235
MeSH35 D012509
SNOMED-CT57 9801004
NCIt40 C27005

Related Diseases for Spindle Cell Sarcoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to spindle cell sarcoma

Clinical Features for Spindle Cell Sarcoma

Drugs & Therapeutics for Spindle Cell Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Spindle Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Spindle Cell Sarcoma

Search NIH Clinical Center for Spindle Cell Sarcoma

Search CenterWatch for Spindle Cell Sarcoma

Genetic Tests for Spindle Cell Sarcoma

Anatomical Context for Spindle Cell Sarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Spindle Cell Sarcoma:

33
Lymph node, Spleen, Heart, Smooth muscle, Kidney, Liver, Lung, Pancreas, Adrenal gland, Breast, Skin, Ovary, Prostate, B cells, Endothelial

Animal Models for Spindle Cell Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Spindle Cell Sarcoma

Sources:
51PubMed
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Articles related to Spindle Cell Sarcoma:

(show top 50)    (show all 170)
idTitleAuthorsYear
1
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide. (23715844)
2013
2
Recurrent cardiac intimal (spindle cell) sarcoma of the left atrium. (21924626)
2013
3
Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. (23129168)
2012
4
Left atrial spindle cell sarcoma - case report. (22929830)
2012
5
Spindle cell sarcoma of the maxillary antrum. (23741844)
2012
6
Jejunal undifferentiated spindle cell sarcoma with glossal metastasis. (22313541)
2012
7
Case of the season: primary pulmonary collision tumor consisting of carcinoid and high-grade spindle-cell sarcoma. (21726700)
2011
8
Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma. (22606579)
2011
9
Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells. (21795355)
2011
10
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. (21883368)
2011
11
Nodular spindle cell proliferation in the wall of a varicose vein mimicking Kaposi's sarcoma. (20412343)
2011
12
Well-differentiated extraskeletal osteosarcoma arising from the retroperitoneum that recurred as anaplastic spindle cell sarcoma. (20224645)
2010
13
Prolonged survival with left atrial spindle cell sarcoma. (19304772)
2009
14
Primary peritoneal spindle cell sarcoma presented with massive ascites: a case report. (20148470)
2009
15
Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change. (18941398)
2009
16
Mucoepidermoid carcinoma with spindle cell change: a low-grade lesion potentially mistaken for sarcomatoid dedifferentiation. (20614320)
2008
17
Primary Spindle Cell Sarcoma of the Breast. (20824039)
2008
18
Right maxillary sinus sarcomatoid carcinoma (sarcomatoid/spindle cell carcinoma). (17666274)
2007
19
Ureteral spindle cell sarcoma in a dog. (17850279)
2007
20
Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. (16538049)
2006
21
What is your diagnosis? Spindle cell sarcoma . (16426184)
2006
22
Spindle cell sarcoma of larynx. (23120325)
2006
23
A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. (15467709)
2005
24
Spindle cell sarcoma of the pericardium: a case report. (15016051)
2004
25
Monophasic sarcomatoid carcinoma of the scalp: a case mimicking inflammatory myofibroblastic tumor and a review of cutaneous spindle cell tumors with myofibroblastic differentiation. (12834489)
2003
26
The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27(Kip1) and cyclin E. (12824885)
2003
27
Coamplification of 12p11 and 12q13 approximately q22 in multiple ring chromosomes in a spindle cell sarcoma resolved by novel multicolor fluorescence in situ hybridization analysis. (12547157)
2002
28
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin. (12010367)
2002
29
Spindle cell sarcoma with neuroepithelial [correction of neuroectodermal] differentiation. (11260312)
2001
30
Syncope in a patient with spindle cell sarcoma of the main pulmonary artery. (11369696)
2001
31
Sarcomatoid chordoma: chordoma with a massive malignant spindle-cell component. (11271555)
2000
32
Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats. (9686439)
1998
33
Phenotype and proliferation characteristics of cultured spindle-shaped cells obtained from normal human skin and lesions of dermatofibroma, Kaposi's sarcoma, and dermatofibrosarcoma protuberans: a comparison with fibroblast and endothelial cells of the dermis. (9438908)
1997
34
Ultrastructural evidence for divergent and alternating differentiations in spindle cell sarcoma xenografts. (9165712)
1997
35
Alteration of the p53 gene of lung carcinomas with sarcomatous transformation (spindle cell carcinoma): analysis of four cases. (10846548)
1996
36
Multicentric undifferentiated spindle-cell sarcoma with virus-like particles in an aged dairy cow. (8592056)
1995
37
Correlation of oncostatin M secretion by human retrovirus-infected cells with potent growth stimulation of cultured spindle cells from AIDS-Kaposi's sarcoma. (8098726)
1993
38
Postoperative spindle cell nodules (PSCN) resembling sarcomas: an atypical granulation tissue or atypical pyogenic granuloma with exuberant myofibroblastic component? (2091012)
1990
39
Spindle-cell sarcoma in patients who have osteochondromatosis. A report of two cases. (3263374)
1988
40
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
41
Atypical fibroxanthoma distinguishable from spindle cell carcinoma in sarcoma-like skin lesions. A clinicopathologic and immunohistochemical study of 21 cases. (2578080)
1985
42
Spindle cell sarcoma of scrotum. (7445295)
1980
43
Malignant neurilemoma of the mediastinum. A variant of spindle cell sarcoma. (5788655)
1969
44
Hypoglycaemia-inducing tumour resembling spindle-cell sarcoma. (13410544)
1957
45
Spindle cell sarcoma of the vagina; a case treated by radium implant. (13320234)
1956
46
Effects of pregnancy and lactation on the growth of a transplantable spindle cell sarcoma in cba mice. (15420329)
1950
47
Spindle cell sarcoma of the hard palate; report of case. (18117042)
1949
48
Spindle-cell Sarcoma of Scarpa's Triangle: Interinnomino-abdominal Amputation. (19991825)
1939
49
SPINDLE CELL SARCOMA OF THE PROSTATE. (20316150)
1927
50
A Positive Focal Tuberculin Reaction in a Spindle-Cell Sarcoma which Had Perforated the Sclera. (16692490)
1919

Genetic Variations for Spindle Cell Sarcoma

Expression for genes affiliated with Spindle Cell Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for genes affiliated with Spindle Cell Sarcoma

Sources:
38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 54Reactome, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CCNE1
29.8CCNE1, TP53
3
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9.7TP53, BCL2
4
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9.6CDKN1B, TP53, CCNE1
5
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9.6CCNE1, CDKN1B, TP53
6
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9.5NF1, TP53, CCNE1
79.5IL6, BCL2, CDKN1B
8
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9.5TP53, IL6, CCNE1
99.4NF1, IL6, BCL2
109.3TP53, NF1, CCNE1, CDKN1B
119.2CCNE1, CDKN1B, BCL2, TP53
129.2CCNE1, TP53, CDKN1B, BCL2
13
Hide members
9.2CCNE1, CDKN1B, TP53, IL6
149.2VIM, CDKN1B, BCL2, TP53
159.2KRT8, KRT13, KRT7, VIM
169.1CDKN1B, IL6, TP53, VIM
179.1BCL2, IL6, TP53, CDKN1B
188.9TP53, BCL2, VIM, CDKN1B, CCNE1
198.9KRT13, KRT8, VIM, DSP, KRT7
208.9BCL2, CCNE1, TP53, CDKN1B, IL6
218.9TP53, BCL2, IL6, CDKN1B, CCNE1
22
Hide members
8.9CCNE1, CDKN1B, IL6, BCL2, TP53
23
Hide members
8.0TP53, VIM, CCNE1, DSP, NF1, CDKN1B

Compounds for genes affiliated with Spindle Cell Sarcoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6KRT8
2estrogen4510.6NF1
3vincristine45 50 1112.0MKI67, VIM
4adriamycin459.9KRT8, VIM, BCL2
5reticulin459.8S100B, VIM, KRT7
6mucicarmine459.8VIM, KRT7, S100B
7tanshinone iia459.7TP53, BCL2
8indole-3-carbinol459.7BCL2, CDKN1B, TP53
9triptolide459.7IL6, BCL2, TP53
10troglitazone45 29 60 1112.6IL6, BCL2, KRT13, CDKN1B
11n-(4-hydroxyphenyl)retinamide459.6BCL2, VIM, TP53
12b 723459.6KRT7, S100B, VIM, KRT8
13fludarabine45 1110.5TP53, BCL2, CDKN1B
14cytarabine45 50 1111.5TP53, CDKN1B, BCL2, VIM
15etoposide45 50 60 1112.5CDKN1B, S100B, VIM, BCL2, KRT8
16bortezomib45 1110.5IL6, CDKN1B, TP53, BCL2
17flavopiridol45 1110.5TP53, CDKN1B, BCL2
18dutp459.4MKI67, TP53, BCL2
19paclitaxel45 50 1111.4TP53, S100B, KRT8, BCL2, CDKN1B
20forskolin45 50 1111.4KRT8, CDKN1B, NF1, S100B, VIM
21roscovitine459.3VIM, BCL2, TP53
22bromodeoxyuridine459.3KRT8, CDKN1B, MKI67, S100B, VIM
23cyclophosphamide45 50 1111.3MKI67, CDKN1B, TP53, BCL2
24thymidylate459.2TP53, VIM, MKI67, BCL2
25genistein45 29 60 2 11 2414.2IL6, CDKN1B, KRT8, VIM, BCL2
26tgf beta1459.2CDKN1B, MKI67, DSP, VIM, IL6
27sb 20358045 6010.2VIM, IL6, TP53, BCL2, CDKN1B
28proline459.0KRT13, S100B, TP53, MKI67, VIM
29hematoxylin459.0S100B, VIM, KRT8, KRT7, MKI67
30formaldehyde45 2410.0CDKN1B, MKI67, KRT7, S100B, VIM
31retinoid459.0TP53, BCL2, KRT7, KRT8, VIM
32lactate459.0S100B, MKI67, IL6, KRT8, VIM
33actinomycin d458.9BCL2, TP53, IL6, CDKN1B, VIM, KRT8
34methotrexate45 50 1110.9KRT7, IL6, CDKN1B, MKI67, VIM
35oligonucleotide458.9TP53, BCL2, CDKN1B, KRT8, VIM, NF1
36cisplatin45 50 60 1111.8MKI67, CDKN1B, TP53, BCL2, KRT8
37thymidine45 249.8IL6, TP53, S100B, CDKN1B, MKI67
38tamoxifen45 50 29 1111.8KRT8, CDKN1B, TP53, MKI67, VIM, BCL2
39doxorubicin45 50 1110.8TP53, CDKN1B, MKI67, KRT8, BCL2, VIM
40glycogen45 249.8KRT8, KRT7, VIM, CDKN1B, MKI67, S100B
415fluorouracil458.6CDKN1B, MKI67, BCL2, TP53
42testosterone45 60 11 2411.4VIM, S100B, MKI67, CDKN1B, IL6, KRT8
43arginine458.3TP53, VIM, KRT7, CDKN1B, S100B, NF1
44lipid458.2KRT7, S100B, KRT8, IL6, VIM, NF1
45tyrosine458.0KRT7, KRT8, DSP, NF1, MKI67, CDKN1B
46serine457.7BCL2, KRT8, CDKN1B, MKI67, NF1, DSP
47vegf457.7S100B, KRT7, BCL2, IL6, TP53, CDKN1B
48paraffin457.5CDKN1B, MKI67, KRT13, BCL2, TP53, KRT7
49progesterone45 60 29 11 2411.2S100B, CCNE1, VIM, TP53, BCL2, KRT8
50retinoic acid45 247.9TP53, VIM, KRT7, IL6, KRT8, CDKN1B

GO Terms for genes affiliated with Spindle Cell Sarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT8, KRT13, KRT7
2intermediate filamentGO:0058829.0VIM, DSP, KRT7, KRT8
3cytoplasmGO:0057376.5TP53, VIM, S100B, AFAP1L1, NF1, MKI67

Biological processes related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.0DSP, VIM
2mitotic cell cycle arrestGO:07185010.0CDKN1B, TP53
3B cell lineage commitmentGO:00232610.0TP53, BCL2
4negative regulation of neuroblast proliferationGO:0074069.9NF1, TP53
5regulation of cell-matrix adhesionGO:0019529.9NF1, BCL2
6negative regulation of mitotic cell cycleGO:0459309.9BCL2, CDKN1B
7response to glucocorticoid stimulusGO:0513849.7BCL2, IL6, S100B
8regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
9positive regulation of apoptotic processGO:0430659.3TP53, IL6, NF1, S100B
10negative regulation of cell growthGO:0303089.2TP53, BCL2, CDKN1B
11modulation by virus of host morphology or physiologyGO:0190488.9VIM, KRT7, KRT8, TP53

Molecular functions related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.7TP53, BCL2
2scaffold protein bindingGO:0971109.5KRT8, DSP, VIM
3structural molecule activityGO:0051988.9DSP, KRT7, KRT13, KRT8
4protein bindingGO:0055155.3NF1, S100B, DSP, CCNE1, MKI67, CDKN1B

Products for genes affiliated with Spindle Cell Sarcoma

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Sources for Spindle Cell Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet