MCID: SPN035
MIFTS: 41

Spindle Cell Sarcoma malady

Cancer diseases category

Aliases & Classifications for Spindle Cell Sarcoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
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Spindle Cell Sarcoma, Aliases & Descriptions:

Name: Spindle Cell Sarcoma 9 11
Sarcoma, Spindle Cell 60
 
Sarcoma Spindle Cell 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:4235
MeSH33 D012509
SNOMED-CT55 9801004
NCIt38 C27005

Summaries for Spindle Cell Sarcoma

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Wikipedia:63 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

MalaCards based summary: Spindle Cell Sarcoma, also known as sarcoma, spindle cell, is related to sarcoma and cholangiocarcinoma. An important gene associated with Spindle Cell Sarcoma is KRT13 (keratin 13), and among its related pathways are Cytoskeletal Signaling and ATF-2 transcription factor network. The compounds olopatadine and reticulin have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and liver, and related mouse phenotypes are renal/urinary system and integument.

Disease Ontology:9 A sarcoma that results in cells that are spindle-shaped. they are usually resistant to radiation therapy.

Related Diseases for Spindle Cell Sarcoma

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Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.5DSP, NF1, KRT8, S100B
2cholangiocarcinoma30.3KRT7, KRT8
3glioblastoma30.0NF1, BCL2, S100B
4sarcoma, synovial29.5KRT7, BCL2, S100B, NF1, KRT13, KRT8
5leopard syndrome10.4DSP
6prostatitis10.4
7endotheliitis10.4
8ovarian brenner tumor10.3KRT13, KRT7
9sex cord-gonadal stromal tumor10.3KRT7, S100B
10malignant mixed mullerian tumor10.3KRT7, S100B
11hepatitis10.3
12spindle cell synovial sarcoma10.3
13fibrous histiocytoma10.3
14fibrosarcoma10.3
15histiocytoma10.3
16thyroiditis10.3
17mucoepidermoid carcinoma10.3KRT7, KRT13
18perineurioma10.3DSP, S100B
19papilloma10.3KRT13
20leukoplakia10.3KRT13, KRT8
21hemangioblastoma10.3KRT8, S100B
22pancreatic ductal carcinoma10.2KRT8, KRT7
23epithelioid sarcoma10.2KRT7, KRT8
24cervical adenocarcinoma10.2KRT8, KRT7
25abrikosov's tumor10.2KRT8, KRT7
26adenosquamous carcinoma10.2KRT8, KRT7
27ameloblastoma10.2KRT7, KRT8
28malignant peripheral nerve sheath tumor10.2S100B, NF1
29gallbladder cancer10.2KRT8, KRT7
30neurofibroma10.2NF1, S100B
31endometrial cancer10.2KRT7, BCL2
32pilocytic astrocytoma10.2NF1, S100B
33oxyphilic adenoma10.2KRT7, KRT8
34ependymoma10.2S100B, NF1
35uveal melanoma10.2KRT8, S100B
36neurofibromatosis10.2S100B, NF1
37skin benign neoplasm10.2KRT13, NF1
38coronary artery disease10.2
39sinusitis10.2
40meckel's diverticulum10.2
41neuronitis10.2
42ectomesenchymoma10.2
43hypoglycemia10.2
44necrotizing fasciitis10.2
45leukemoid reaction10.2
46neurofibrosarcoma10.2
47phaeochromocytoma10.2
48artery disease10.2
49eosinophilia10.2
50fasciitis10.2

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to spindle cell sarcoma

Symptoms for Spindle Cell Sarcoma

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Drugs & Therapeutics for Spindle Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Sarcoma

Search NIH Clinical Center for Spindle Cell Sarcoma

Genetic Tests for Spindle Cell Sarcoma

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Anatomical Context for Spindle Cell Sarcoma

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MalaCards organs/tissues related to Spindle Cell Sarcoma:

31
Kidney, Lung, Liver, Skin, Heart, Breast, Bone, Prostate, Endothelial, Thyroid, Spleen, Smooth muscle, Adrenal gland, Tongue, Neutrophil

Animal Models for Spindle Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6KRT7, NF1, BCL2, IL6
2MP:00107718.1NF1, S100B, BCL2, IL6, DSP

Publications for Spindle Cell Sarcoma

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Articles related to Spindle Cell Sarcoma:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
A Unilateral Hemothorax as a Presenting Manifestation of Mediastinal Spindle Cell Sarcoma. (25416071)
2015
2
Spindle cell sarcoma of the left atrium: an extremely rare and challenging tumour often masquerading as left atrial myxoma. (25547565)
2015
3
High-grade spindle cell sarcoma of the heart: a case report and review of literature. (25888133)
2015
4
A spindle cell sarcoma of liver supplied by internal mammary artery. (25533497)
2015
5
Spindle cell sarcoma of pulmonary artery mimicking thromboembolism with lung metastasis detected in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. (25400365)
2014
6
Spindle cell sarcoma of thyroid: a case report. (25767348)
2014
7
Spindle cell sarcoma of the mitral valve: an unusual cause of acute coronary syndrome in a child. (25282213)
2014
8
Spindle Cell Sarcoma of the Vulva With Myofibroblastic Differentiation. (25062403)
2014
9
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. (22951535)
2013
10
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide. (23715844)
2013
11
An unusually large spindle cell sarcoma of the tongue in a male child. (24669028)
2013
12
Recurrent cardiac intimal (spindle cell) sarcoma of the left atrium. (21924626)
2013
13
Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. (23129168)
2012
14
Case of the season: primary pulmonary collision tumor consisting of carcinoid and high-grade spindle-cell sarcoma. (21726700)
2011
15
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (21516130)
2011
16
Eosinophilic and neutrophilic leukemoid reaction in a woman with spindle cell sarcoma: a case report. (20964813)
2010
17
A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall. (21319519)
2010
18
Prolonged survival with left atrial spindle cell sarcoma. (19304772)
2009
19
Primary peritoneal spindle cell sarcoma presented with massive ascites: a case report. (20148470)
2009
20
Recurrence of a laryngeal spindle cell sarcoma with a transformation into a higher grade of malignancy. (19121902)
2009
21
Radiation-induced spindle cell sarcoma: a rare case report. (19884729)
2009
22
Re: Spindle cell sarcoma of the profundua femoris vein, mimicking deep venous thrombosis. (18625364)
2008
23
Cardioembolic stroke in a patient with spindle cell sarcoma of the left atrium. (17400125)
2007
24
Primary spindle cell sarcoma of the vagina treated with neoadjuvant radiation and pelvic exenteration. (17415115)
2007
25
What is your diagnosis? Spindle cell sarcoma . (16426184)
2006
26
Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. (15893992)
2005
27
Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. (15661546)
2005
28
Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma. (15208086)
2004
29
Coamplification of 12p11 and 12q13 approximately q22 in multiple ring chromosomes in a spindle cell sarcoma resolved by novel multicolor fluorescence in situ hybridization analysis. (12547157)
2002
30
Successful treatment of spindle cell sarcoma of the sella turcica. Case report. (12507071)
2002
31
Spindle cell sarcoma with neuroepithelial [correction of neuroectodermal] differentiation. (11260312)
2001
32
Spindle cell sarcoma of the kidney with ganglionic elements (malignant ectomesenchymoma) associated with chromosomal abnormalities and a review of the literature. (9544170)
1998
33
Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats. (9686439)
1998
34
Predictive value of proliferation-related markers, p53, and DNA ploidy for survival in patients with soft tissue spindle-cell sarcomas. (8878024)
1996
35
Neonatal colorectal spindle cell sarcoma. (1501050)
1992
36
Spindle-cell sarcoma of the hand may present as a benign recurrent nodule. (1544980)
1992
37
High-dose interferon-beta in treatment of spindle-cell sarcoma of breast. (2145946)
1990
38
Spindle cell sarcoma showing concentration of Tc-99m sodium pertechnetate and Tc-99m (V) DMSA. (2155729)
1990
39
Spindle-cell sarcoma of the female breast. (16312854)
1989
40
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
41
Spindle cell sarcoma of scrotum. (7445295)
1980
42
Late reappearance of spindle cell sarcoma of the thigh: a case report. (6075633)
1967
43
Preliminary report on a spindle-cell sarcoma in the Syrian hamster produced by thorotrast. (5969491)
1966
44
BILATERAL TESTICULAR TUMORS: SPINDLE CELL SARCOMA AND SEMINOMA; CASE REPORT. (14044197)
1963
45
SPONTANEOUS hypoglycemia with abdominal spindle-cell sarcoma. (13857105)
1960
46
Spindle cell sarcoma of the kidney with associated eosinophilia. (13634328)
1959
47
Two cases of spindle-cell sarcoma of the rectum. (13281668)
1955
48
Spindle cell sarcoma of the hard palate; report of case. (18117042)
1949
49
A case of spindle-cell sarcoma of the stomach. (18921023)
1947
50
SPINDLE CELL SARCOMA OF THE PROSTATE. (20316150)
1927

Variations for Spindle Cell Sarcoma

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Expression for genes affiliated with Spindle Cell Sarcoma

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Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for genes affiliated with Spindle Cell Sarcoma

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Pathways related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3KRT8, KRT7, KRT13
29.1NF1, BCL2, IL6
38.9KRT13, KRT7, KRT8, DSP
4
Show member pathways
8.7NF1, BCL2, IL6, DSP

Compounds for genes affiliated with Spindle Cell Sarcoma

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Compounds related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1olopatadine43 1211.1S100B, IL6
2reticulin4310.0KRT7, S100B
3mucicarmine4310.0KRT7, S100B
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.9BCL2, S100B
5triptolide439.8BCL2, IL6
6mitoxantrone43 49 1211.8KRT8, BCL2
7b 723439.6KRT7, KRT8, S100B
8hematoxylin439.6KRT7, KRT8, S100B
9troglitazone43 28 59 1212.6IL6, BCL2, KRT13
10etoposide43 49 59 1212.6BCL2, S100B, KRT8
11paclitaxel43 49 1211.5KRT8, S100B, BCL2
12forskolin43 49 1211.5S100B, NF1, KRT8
13rituximab43 49 1211.5BCL2, IL6
14glycogen43 2410.5S100B, KRT8, KRT7
15ibuprofen43 28 49 24 1213.4IL6, BCL2
16retinoid439.4KRT7, KRT8, BCL2
17steroid439.3KRT8, NF1, S100B, DSP
18actinomycin d439.3KRT8, BCL2, IL6
19iron43 2410.3KRT7, KRT8, S100B
20genistein43 28 59 2 24 1214.2KRT8, BCL2, IL6
21testosterone43 59 24 1212.1IL6, S100B, KRT8, KRT7
22glucose439.0KRT7, KRT8, S100B, IL6
23lactate439.0KRT8, S100B, IL6
24serine438.8DSP, BCL2, S100B, NF1, KRT8
25calcium43 49 24 1211.8DSP, S100B, NF1, KRT8, KRT13
26lipid438.7IL6, S100B, NF1, KRT8, KRT7
27vegf438.7IL6, BCL2, S100B, KRT8, KRT7
28paraffin438.4BCL2, S100B, NF1, KRT8, KRT7, KRT13
29tyrosine438.4DSP, IL6, S100B, NF1, KRT8, KRT7
30progesterone43 28 59 24 1212.4DSP, BCL2, S100B, NF1, KRT8, KRT7
31estrogen438.3IL6, BCL2, S100B, NF1, KRT8, KRT7
32retinoic acid43 248.6KRT13, DSP, IL6, BCL2, S100B, NF1

GO Terms for genes affiliated with Spindle Cell Sarcoma

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Cellular components related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.2KRT13, KRT7, KRT8
2intermediate filamentGO:00058828.9KRT7, KRT8, DSP
3cytoplasmGO:00057377.7BCL2, S100B, NF1, KRT8, KRT7, AFAP1L1

Biological processes related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:00093149.9BCL2, KRT13
2regulation of angiogenesisGO:00457659.9NF1, IL6
3regulation of cell-matrix adhesionGO:00019529.8NF1, BCL2
4metanephros developmentGO:00016569.7NF1, BCL2
5extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7NF1, BCL2
6axonogenesisGO:00074099.6S100B, BCL2
7cell growthGO:00160499.6BCL2, IL6
8positive regulation of peptidyl-serine phosphorylationGO:00331389.6BCL2, IL6
9negative regulation of protein kinase activityGO:00064699.5NF1, IL6
10humoral immune responseGO:00069599.5IL6, BCL2
11response to glucocorticoidGO:00513849.4S100B, BCL2, IL6
12positive regulation of apoptotic processGO:00430659.4IL6, S100B, NF1
13wound healingGO:00420609.4NF1, DSP

Molecular functions related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971109.8KRT8, DSP
2structural molecule activityGO:00051988.8KRT13, KRT7, KRT8, DSP
3protein bindingGO:00055156.4TLE2, DSP, IL6, BCL2, S100B, NF1

Products for genes affiliated with Spindle Cell Sarcoma

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Sources for Spindle Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet