MCID: SPN035
MIFTS: 53

Spindle Cell Sarcoma malady

Cancer diseases category

Summaries for Spindle Cell Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

MalaCards: Spindle Cell Sarcoma, also known as sarcoma, spindle cell, is related to sarcoma and kaposi's sarcoma. An important gene associated with Spindle Cell Sarcoma is KRT13 (keratin 13), and among its related pathways are miRNAs involved in DDR and PLK3 signaling events. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lung, and related mouse phenotypes are renal/urinary system and pigmentation.

Disease Ontology:8 A sarcoma that results in cells that are spindle-shaped. they are usually resistant to radiation therapy.

Aliases & Classifications for Spindle Cell Sarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell sarcoma 8 10
sarcoma, spindle cell 60
sarcoma spindle cell 44


External Ids:

Disease Ontology8 DOID:4235
MeSH34 D012509
SNOMED-CT56 9801004
NCIt39 C27005

Related Diseases for Spindle Cell Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to spindle cell sarcoma

Clinical Features for Spindle Cell Sarcoma

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Drugs & Therapeutics for Spindle Cell Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Sarcoma

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Genetic Tests for Spindle Cell Sarcoma

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Anatomical Context for Spindle Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Sarcoma:

32
Kidney, Skin, Lung, Liver, Endothelial, Heart, Breast, Bone, Prostate, Smooth muscle, Adrenal gland, Spleen

Animal Models for Spindle Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2KRT7
2MP:00011869.9NF1
3MP:00053699.7NF1, TP53
4MP:00036319.0BCL2, OLFM1, NF1
5MP:00053888.9NF1, CDKN1B, IL6, BCL2, TP53
6MP:00107718.9TP53, BCL2, IL6, CDKN1B, S100B, CCNE1
7MP:00020068.8CCNE1, NF1, CDKN1B, IL6, BCL2, TP53
8MP:00053818.7CCNE1, CDKN1B, IL6, KRT8, BCL2, TP53
9MP:00053898.6CCNE1, CDKN1B, OLFM1, BCL2, TP53
10MP:00053918.4VIM, NF1, CDKN1B, IL6, BCL2, TP53
11MP:00053858.2VIM, CCNE1, NF1, CDKN1B, IL6, KRT8
12MP:00053878.0VIM, CCNE1, NF1, CDKN1B, IL6, KRT8
13MP:00053787.9VIM, CCNE1, DSP, NF1, CDKN1B, IL6
14MP:00053847.7VIM, CCNE1, DSP, NF1, CDKN1B, IL6

Publications for Spindle Cell Sarcoma

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50PubMed
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Articles related to Spindle Cell Sarcoma:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
Primary intimal (spindle cell) sarcoma of the heart: a case report and review of the literature. (23424592)
2013
2
Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. (23129168)
2012
3
Primary pericardial spindle cell sarcoma mimicking left main coronary artery disease. (22219472)
2012
4
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (21516130)
2011
5
Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells. (21795355)
2011
6
Nodular spindle cell proliferation in the wall of a varicose vein mimicking Kaposi's sarcoma. (20412343)
2011
7
A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall. (21319519)
2010
8
High-grade spindle cell sarcoma arising in rhytidectomy scar: a case report. (19717353)
2010
9
Spindle cells from AIDS-associated Kaposi's sarcoma lesions express telomerase activity that is enhanced by Kaposi's sarcoma progression factors. (20514465)
2010
10
Case report: spindle cell sarcoma of the profunda femoris vein mimicking deep venous thrombosis. (18194701)
2008
11
Primary Spindle Cell Sarcoma of the Breast. (20824039)
2008
12
Cardioembolic stroke in a patient with spindle cell sarcoma of the left atrium. (17400125)
2007
13
Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development. (16615115)
2006
14
Spindle cell sarcoma of larynx. (23120325)
2006
15
Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. (15893992)
2005
16
Spindle cell sarcoma: a rare cause of a large abdominal mass. (15591490)
2005
17
Alpha-chemokine-mediated signal transduction in human Kaposi's sarcoma spindle cells. (15110993)
2004
18
Fine needle aspiration cytology of clear cell sarcoma of the kidney with spindle cell pattern. (12828728)
2003
19
Epithelioid sarcoma: an immunohistochemical analysis evaluating the utility of cytokeratin 5/6 in distinguishing superficial epithelioid sarcoma from spindled squamous cell carcinoma. (12641789)
2003
20
Successful treatment of spindle cell sarcoma of the sella turcica. Case report. (12507071)
2002
21
Use of ultrasonography in the diagnosis of hepatic spindle-cell sarcoma in a savannah monitor (Varanus exanthematicus). (11918052)
2002
22
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin. (12010367)
2002
23
Spindle cell variant of epithelioid sarcoma: an easily misdiagnosed tumour. (11309041)
2001
24
Identification of syt-ssx fusion transcripts in both epithelial and spindle cell components of biphasic synovial sarcoma in small tissue samples isolated by membrane-based laser microdissection. (11561755)
2001
25
Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures. (11356969)
2001
26
Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats. (9686439)
1998
27
Ultrastructural evidence for divergent and alternating differentiations in spindle cell sarcoma xenografts. (9165712)
1997
28
Predictive value of proliferation-related markers, p53, and DNA ploidy for survival in patients with soft tissue spindle-cell sarcomas. (8878024)
1996
29
Corticomedullary tumors of the adrenal glands. Report of two cases. Association of corticomedullary tumor with spindle cell sarcoma. (9122025)
1996
30
Multicentric undifferentiated spindle-cell sarcoma with virus-like particles in an aged dairy cow. (8592056)
1995
31
Monophasic spindle cell synovial sarcoma of the head and neck: report of two cases an review of the literature. (8308633)
1994
32
Combined spindle cell sarcoma/phaeochromocytoma of the adrenal. (8314241)
1993
33
Correlation of oncostatin M secretion by human retrovirus-infected cells with potent growth stimulation of cultured spindle cells from AIDS-Kaposi's sarcoma. (8098726)
1993
34
The fibroma-like variant of epithelioid sarcoma. A fibrohistiocytic/myoid cell lesion often confused with benign and malignant spindle cell tumors. (1371711)
1992
35
Spindle-cell sarcoma of the female breast. (16312854)
1989
36
Spindle-cell sarcoma in patients who have osteochondromatosis. A report of two cases. (3263374)
1988
37
Spindle-cell sarcoma in patients who have osteochondromatosis. A report of two cases. (2826487)
1988
38
Spindle cell sarcoma of the heart in childhood: light microscopic, ultrastructural, and immunohistochemical evidence for smooth muscle, endothelial, and fibroblastic differentiation. (3244601)
1988
39
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
40
Poorly differentiated fibrosarcoma (spindle cell sarcoma) involving the temporal bone. (3785903)
1986
41
Reactive spindle cell nodule of the endocervix simulating uterine sarcoma. (4055221)
1985
42
Spindle cell sarcoma of the pulmonary trunk: a case report with histochemistry and electron microscopy. (469655)
1979
43
Pleomorphic spindle-cell carcinoma of the gallbladder. Relation to sarcoma of the gallbladder. (5416826)
1970
44
Retroperitoneal spindle cell sarcoma. (5807656)
1969
45
BILATERAL TESTICULAR TUMORS: SPINDLE CELL SARCOMA AND SEMINOMA; CASE REPORT. (14044197)
1963
46
Hypoglycaemia-inducing tumour resembling spindle-cell sarcoma. (13410544)
1957
47
Two cases of spindle-cell sarcoma of the rectum. (13281668)
1955
48
Spindle-cell sarcoma in the black leopard (panthera pardus). (13112222)
1953
49
Primary spindle cell sarcoma of the urinary bladder with solitary metastasis to the heart muscle. (20990742)
1946
50
Spindle-cell Sarcoma of Scarpa's Triangle: Interinnomino-abdominal Amputation. (19991825)
1939

Genetic Variations for Spindle Cell Sarcoma

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Expression for genes affiliated with Spindle Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for genes affiliated with Spindle Cell Sarcoma

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37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CCNE1
29.8TP53, CCNE1
3
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9.7TP53, BCL2
4
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9.6TP53, CDKN1B, CCNE1
5
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9.6CCNE1, CDKN1B, TP53
6
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9.5TP53, NF1, CCNE1
79.5BCL2, IL6, CDKN1B
8
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9.5CCNE1, IL6, TP53
99.4NF1, IL6, BCL2
109.3TP53, CDKN1B, NF1, CCNE1
119.2CCNE1, CDKN1B, BCL2, TP53
129.2TP53, BCL2, CDKN1B, CCNE1
13
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9.2TP53, IL6, CDKN1B, CCNE1
149.2TP53, BCL2, CDKN1B, VIM
159.2VIM, KRT7, KRT13, KRT8
169.1VIM, CDKN1B, IL6, TP53
179.1CDKN1B, IL6, BCL2, TP53
188.9VIM, CCNE1, CDKN1B, BCL2, TP53
198.9KRT8, KRT13, KRT7, DSP, VIM
208.9CCNE1, CDKN1B, IL6, BCL2, TP53
218.9CCNE1, CDKN1B, IL6, BCL2, TP53
22
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8.9CCNE1, CDKN1B, IL6, BCL2, TP53
23
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8.0VIM, CCNE1, DSP, NF1, CDKN1B, IL6

Compounds for genes affiliated with Spindle Cell Sarcoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6KRT8
2estrogen4410.6NF1
3vincristine44 49 1112.0MKI67, VIM
4adriamycin449.9KRT8, VIM, BCL2
5reticulin449.8S100B, VIM, KRT7
6mucicarmine449.8VIM, KRT7, S100B
7tanshinone iia449.7TP53, BCL2
8indole-3-carbinol449.7BCL2, CDKN1B, TP53
9triptolide449.7IL6, BCL2, TP53
10troglitazone44 28 59 1112.6IL6, BCL2, KRT13, CDKN1B
11n-(4-hydroxyphenyl)retinamide449.6BCL2, VIM, TP53
12b 723449.6KRT7, S100B, VIM, KRT8
13fludarabine44 1110.5TP53, BCL2, CDKN1B
14cytarabine44 49 1111.5TP53, CDKN1B, BCL2, VIM
15etoposide44 49 59 1112.5CDKN1B, S100B, VIM, BCL2, KRT8
16bortezomib44 1110.5IL6, CDKN1B, TP53, BCL2
17flavopiridol44 1110.5TP53, CDKN1B, BCL2
18dutp449.4MKI67, TP53, BCL2
19paclitaxel44 49 1111.4TP53, S100B, KRT8, BCL2, CDKN1B
20forskolin44 49 1111.4KRT8, CDKN1B, NF1, S100B, VIM
21roscovitine449.3VIM, BCL2, TP53
22bromodeoxyuridine449.3KRT8, CDKN1B, MKI67, S100B, VIM
23cyclophosphamide44 49 1111.3MKI67, CDKN1B, TP53, BCL2
24thymidylate449.2TP53, VIM, MKI67, BCL2
25genistein44 28 59 2 11 2414.2IL6, CDKN1B, KRT8, VIM, BCL2
26tgf beta1449.2CDKN1B, MKI67, DSP, VIM, IL6
27sb 20358044 5910.2VIM, IL6, TP53, BCL2, CDKN1B
28proline449.0KRT13, S100B, TP53, MKI67, VIM
29hematoxylin449.0S100B, VIM, KRT8, KRT7, MKI67
30formaldehyde44 2410.0CDKN1B, MKI67, KRT7, S100B, VIM
31retinoid449.0TP53, BCL2, KRT7, KRT8, VIM
32lactate449.0S100B, MKI67, IL6, KRT8, VIM
33actinomycin d448.9BCL2, TP53, IL6, CDKN1B, VIM, KRT8
34methotrexate44 49 1110.9KRT7, IL6, CDKN1B, MKI67, VIM
35oligonucleotide448.9TP53, BCL2, CDKN1B, KRT8, VIM, NF1
36cisplatin44 49 59 1111.8MKI67, CDKN1B, TP53, BCL2, KRT8
37thymidine44 249.8IL6, TP53, S100B, CDKN1B, MKI67
38tamoxifen44 49 28 1111.8KRT8, CDKN1B, TP53, MKI67, VIM, BCL2
39doxorubicin44 49 1110.8TP53, CDKN1B, MKI67, KRT8, BCL2, VIM
40glycogen44 249.8KRT8, KRT7, VIM, CDKN1B, MKI67, S100B
415fluorouracil448.6CDKN1B, MKI67, BCL2, TP53
42testosterone44 59 11 2411.4VIM, S100B, MKI67, CDKN1B, IL6, KRT8
43arginine448.3TP53, VIM, KRT7, CDKN1B, S100B, NF1
44lipid448.2KRT7, S100B, KRT8, IL6, VIM, NF1
45tyrosine448.0KRT7, KRT8, DSP, NF1, MKI67, CDKN1B
46serine447.7BCL2, KRT8, CDKN1B, MKI67, NF1, DSP
47vegf447.7S100B, KRT7, BCL2, IL6, TP53, CDKN1B
48paraffin447.5CDKN1B, MKI67, KRT13, BCL2, TP53, KRT7
49progesterone44 59 28 11 2411.2S100B, CCNE1, VIM, TP53, BCL2, KRT8
50retinoic acid44 247.9TP53, VIM, KRT7, IL6, KRT8, CDKN1B

GO Terms for genes affiliated with Spindle Cell Sarcoma

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16Gene Ontology
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Cellular components related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT8, KRT13, KRT7
2intermediate filamentGO:0058829.0KRT8, KRT7, DSP, VIM
3cytoplasmGO:0057376.5VIM, S100B, AFAP1L1, NF1, MKI67, CDKN1B

Biological processes related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.0DSP, VIM
2mitotic cell cycle arrestGO:07185010.0CDKN1B, TP53
3B cell lineage commitmentGO:00232610.0TP53, BCL2
4negative regulation of neuroblast proliferationGO:0074069.9NF1, TP53
5regulation of cell-matrix adhesionGO:0019529.9NF1, BCL2
6negative regulation of mitotic cell cycleGO:0459309.9BCL2, CDKN1B
7response to glucocorticoid stimulusGO:0513849.7BCL2, IL6, S100B
8regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
9positive regulation of apoptotic processGO:0430659.3TP53, IL6, NF1, S100B
10negative regulation of cell growthGO:0303089.2TP53, BCL2, CDKN1B
11modulation by virus of host morphology or physiologyGO:0190488.9VIM, KRT7, KRT8, TP53

Molecular functions related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.7TP53, BCL2
2scaffold protein bindingGO:0971109.5VIM, DSP, KRT8
3structural molecule activityGO:0051988.9KRT8, KRT13, KRT7, DSP
4protein bindingGO:0055155.3TP53, VIM, CCNE1, TLE2, S100B, DSP

Products for genes affiliated with Spindle Cell Sarcoma

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  • Antibodies
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Sources for Spindle Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet