MCID: SPN035
MIFTS: 49

Spindle Cell Sarcoma malady

Cancer diseases category
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Summaries for Spindle Cell Sarcoma

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Wikipedia:65 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

MalaCards based summary: Spindle Cell Sarcoma, also known as sarcoma, spindle cell, is related to sarcoma and cholangiocarcinoma. An important gene associated with Spindle Cell Sarcoma is KRT13 (keratin 13), and among its related pathways are Cytoskeletal Signaling and ATF-2 transcription factor network. The compounds olopatadine and reticulin have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and liver, and related mouse phenotypes are renal/urinary system and integument.

Disease Ontology:8 A sarcoma that results in cells that are spindle-shaped. they are usually resistant to radiation therapy.

Aliases & Classifications for Spindle Cell Sarcoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
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Spindle Cell Sarcoma, Aliases & Descriptions:

Name: Spindle Cell Sarcoma 8 10
Sarcoma, Spindle Cell 62
 
Sarcoma Spindle Cell 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4235
MeSH34 D012509
SNOMED-CT57 9801004
NCIt39 C27005

Related Diseases for Spindle Cell Sarcoma

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Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.5DSP, NF1, KRT8, S100B
2cholangiocarcinoma30.3KRT7, KRT8
3glioblastoma30.0NF1, BCL2, S100B
4synovial sarcoma29.9KRT7, BCL2, S100B, NF1, KRT13, KRT8
5kaposi's sarcoma10.5
6leopard syndrome10.4DSP
7venous thrombosis10.4
8endotheliitis10.4
9ovarian brenner tumor10.3KRT13, KRT7
10sex cord-gonadal stromal tumor10.3KRT7, S100B
11malignant mixed mullerian tumor10.3KRT7, S100B
12hepatitis10.3
13spindle cell synovial sarcoma10.3
14fibrous histiocytoma10.3
15fibrosarcoma10.3
16histiocytoma10.3
17osteosarcoma10.3
18prostatitis10.3
19mucoepidermoid carcinoma10.3KRT7, KRT13
20perineurioma10.3DSP, S100B
21papilloma10.3KRT13
22leukoplakia10.3KRT13, KRT8
23hemangioblastoma10.3KRT8, S100B
24pancreatic ductal carcinoma10.3KRT8, KRT7
25epithelioid sarcoma10.2KRT7, KRT8
26cervical adenocarcinoma10.2KRT8, KRT7
27abrikosov's tumor10.2KRT8, KRT7
28adenosquamous carcinoma10.2KRT8, KRT7
29ameloblastoma10.2KRT7, KRT8
30malignant peripheral nerve sheath tumor10.2S100B, NF1
31gallbladder cancer10.2KRT8, KRT7
32neurofibroma10.2NF1, S100B
33endometrial carcinoma10.2KRT7, BCL2
34pilocytic astrocytoma10.2NF1, S100B
35oxyphilic adenoma10.2KRT7, KRT8
36ependymoma10.2S100B, NF1
37uveal melanoma10.2KRT8, S100B
38neurofibromatosis10.2S100B, NF1
39skin benign neoplasm10.2KRT13, NF1
40leiomyosarcoma10.2S100B, KRT8
41sinusitis10.2
42meckel's diverticulum10.2
43hypoglycemia10.2
44necrotizing fasciitis10.2
45phaeochromocytoma10.2
46neuronitis10.2
47ectomesenchymoma10.2
48leukemoid reaction10.2
49neurofibrosarcoma10.2
50artery disease10.2

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to spindle cell sarcoma

Symptoms for Spindle Cell Sarcoma

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Drugs & Therapeutics for Spindle Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Sarcoma

Search NIH Clinical Center for Spindle Cell Sarcoma

Genetic Tests for Spindle Cell Sarcoma

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Anatomical Context for Spindle Cell Sarcoma

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MalaCards organs/tissues related to Spindle Cell Sarcoma:

32
Kidney, Lung, Liver, Skin, Breast, Bone, Heart, Endothelial, Prostate, Spleen, Smooth muscle, Thyroid, Adrenal gland, Tongue, Neutrophil

Animal Models for Spindle Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6KRT7, NF1, BCL2, IL6
2MP:00107718.1NF1, S100B, BCL2, IL6, DSP

Publications for Spindle Cell Sarcoma

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Articles related to Spindle Cell Sarcoma:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child. (25139254)
2014
2
Spindle cell sarcoma of pulmonary artery mimicking thromboembolism with lung metastasis detected in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. (25400365)
2014
3
Spindle cell sarcoma of the mitral valve: an unusual cause of acute coronary syndrome in a child. (25282213)
2014
4
Spindle Cell Sarcoma of the Vulva With Myofibroblastic Differentiation. (25062403)
2014
5
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. (22951535)
2013
6
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide. (23715844)
2013
7
An unusually large spindle cell sarcoma of the tongue in a male child. (24669028)
2013
8
Recurrent cardiac intimal (spindle cell) sarcoma of the left atrium. (21924626)
2013
9
Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. (23129168)
2012
10
Case of the season: primary pulmonary collision tumor consisting of carcinoid and high-grade spindle-cell sarcoma. (21726700)
2011
11
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (21516130)
2011
12
Eosinophilic and neutrophilic leukemoid reaction in a woman with spindle cell sarcoma: a case report. (20964813)
2010
13
A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall. (21319519)
2010
14
Prolonged survival with left atrial spindle cell sarcoma. (19304772)
2009
15
Primary peritoneal spindle cell sarcoma presented with massive ascites: a case report. (20148470)
2009
16
Recurrence of a laryngeal spindle cell sarcoma with a transformation into a higher grade of malignancy. (19121902)
2009
17
Radiation-induced spindle cell sarcoma: a rare case report. (19884729)
2009
18
Re: Spindle cell sarcoma of the profundua femoris vein, mimicking deep venous thrombosis. (18625364)
2008
19
Cardioembolic stroke in a patient with spindle cell sarcoma of the left atrium. (17400125)
2007
20
Primary spindle cell sarcoma of the vagina treated with neoadjuvant radiation and pelvic exenteration. (17415115)
2007
21
Ureteral spindle cell sarcoma in a dog. (17850279)
2007
22
What is your diagnosis? Spindle cell sarcoma . (16426184)
2006
23
Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. (15893992)
2005
24
Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. (15661546)
2005
25
Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma. (15208086)
2004
26
The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27(Kip1) and cyclin E. (12824885)
2003
27
Coamplification of 12p11 and 12q13 approximately q22 in multiple ring chromosomes in a spindle cell sarcoma resolved by novel multicolor fluorescence in situ hybridization analysis. (12547157)
2002
28
Successful treatment of spindle cell sarcoma of the sella turcica. Case report. (12507071)
2002
29
Spindle cell sarcoma with neuroepithelial [correction of neuroectodermal] differentiation. (11260312)
2001
30
Spindle cell sarcoma of the kidney with ganglionic elements (malignant ectomesenchymoma) associated with chromosomal abnormalities and a review of the literature. (9544170)
1998
31
Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats. (9686439)
1998
32
Predictive value of proliferation-related markers, p53, and DNA ploidy for survival in patients with soft tissue spindle-cell sarcomas. (8878024)
1996
33
Combined spindle cell sarcoma/phaeochromocytoma of the adrenal. (8314241)
1993
34
Neonatal colorectal spindle cell sarcoma. (1501050)
1992
35
Spindle-cell sarcoma of the hand may present as a benign recurrent nodule. (1544980)
1992
36
High-dose interferon-beta in treatment of spindle-cell sarcoma of breast. (2145946)
1990
37
Spindle cell sarcoma showing concentration of Tc-99m sodium pertechnetate and Tc-99m (V) DMSA. (2155729)
1990
38
Spindle-cell sarcoma of the female breast. (16312854)
1989
39
Spindle-cell sarcoma in patients who have osteochondromatosis. A report of two cases. (3263374)
1988
40
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
41
Spindle cell sarcoma of scrotum. (7445295)
1980
42
Late reappearance of spindle cell sarcoma of the thigh: a case report. (6075633)
1967
43
Preliminary report on a spindle-cell sarcoma in the Syrian hamster produced by thorotrast. (5969491)
1966
44
BILATERAL TESTICULAR TUMORS: SPINDLE CELL SARCOMA AND SEMINOMA; CASE REPORT. (14044197)
1963
45
SPONTANEOUS hypoglycemia with abdominal spindle-cell sarcoma. (13857105)
1960
46
Spindle cell sarcoma of the kidney with associated eosinophilia. (13634328)
1959
47
Two cases of spindle-cell sarcoma of the rectum. (13281668)
1955
48
Spindle cell sarcoma of the hard palate; report of case. (18117042)
1949
49
A case of spindle-cell sarcoma of the stomach. (18921023)
1947
50
SPINDLE CELL SARCOMA OF THE PROSTATE. (20316150)
1927

Variations for Spindle Cell Sarcoma

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Expression for genes affiliated with Spindle Cell Sarcoma

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Expression patterns in normal tissues for genes affiliated with Spindle Cell Sarcoma

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Pathways for genes affiliated with Spindle Cell Sarcoma

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Pathways related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3KRT8, KRT7, KRT13
29.1NF1, BCL2, IL6
38.9KRT13, KRT7, KRT8, DSP
4
Show member pathways
8.7NF1, BCL2, IL6, DSP

Compounds for genes affiliated with Spindle Cell Sarcoma

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Compounds related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1olopatadine44 1111.1IL6, S100B
2reticulin4410.0KRT7, S100B
3mucicarmine4410.0KRT7, S100B
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9S100B, BCL2
5triptolide449.8IL6, BCL2
6mitoxantrone44 50 1111.8KRT8, BCL2
7b 723449.6KRT7, S100B, KRT8
8hematoxylin449.6S100B, KRT8, KRT7
9troglitazone44 28 61 1112.6IL6, KRT13, BCL2
10etoposide44 50 61 1112.6S100B, KRT8, BCL2
11paclitaxel44 50 1111.5KRT8, S100B, BCL2
12forskolin44 50 1111.5NF1, S100B, KRT8
13rituximab44 50 1111.5IL6, BCL2
14glycogen44 2410.5KRT8, S100B, KRT7
15ibuprofen44 28 50 24 1113.4IL6, BCL2
16retinoid449.4KRT7, BCL2, KRT8
17steroid449.3NF1, KRT8, S100B, DSP
18actinomycin d449.3KRT8, BCL2, IL6
19iron44 2410.3KRT8, KRT7, S100B
20genistein44 28 61 2 24 1114.2BCL2, KRT8, IL6
21testosterone44 61 24 1112.1S100B, IL6, KRT7, KRT8
22glucose449.0KRT7, KRT8, S100B, IL6
23lactate449.0IL6, KRT8, S100B
24serine448.8BCL2, DSP, S100B, KRT8, NF1
25calcium44 50 24 1111.8KRT8, NF1, S100B, DSP, KRT13
26lipid448.7S100B, KRT7, KRT8, NF1, IL6
27vegf448.7KRT7, KRT8, S100B, BCL2, IL6
28paraffin448.4BCL2, S100B, NF1, KRT8, KRT7, KRT13
29tyrosine448.4KRT7, KRT8, NF1, S100B, DSP, IL6
30progesterone44 28 61 24 1112.4KRT8, KRT7, NF1, S100B, DSP, BCL2
31estrogen448.3IL6, BCL2, S100B, KRT8, KRT7, NF1
32retinoic acid44 248.6IL6, KRT13, KRT7, KRT8, NF1, S100B

GO Terms for genes affiliated with Spindle Cell Sarcoma

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Cellular components related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.2KRT13, KRT7, KRT8
2intermediate filamentGO:0058828.9KRT7, KRT8, DSP
3cytoplasmGO:0057377.7BCL2, S100B, NF1, KRT8, KRT7, AFAP1L1

Biological processes related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:0093149.9BCL2, KRT13
2regulation of angiogenesisGO:0457659.9NF1, IL6
3regulation of cell-matrix adhesionGO:0019529.8NF1, BCL2
4metanephros developmentGO:0016569.7NF1, BCL2
5extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7NF1, BCL2
6axonogenesisGO:0074099.6S100B, BCL2
7cell growthGO:0160499.6BCL2, IL6
8positive regulation of peptidyl-serine phosphorylationGO:0331389.6BCL2, IL6
9negative regulation of protein kinase activityGO:0064699.5NF1, IL6
10humoral immune responseGO:0069599.5IL6, BCL2
11response to glucocorticoidGO:0513849.4S100B, BCL2, IL6
12positive regulation of apoptotic processGO:0430659.4IL6, S100B, NF1
13wound healingGO:0420609.4NF1, DSP

Molecular functions related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.8KRT8, DSP
2structural molecule activityGO:0051988.8KRT13, KRT7, KRT8, DSP
3protein bindingGO:0055156.4TLE2, DSP, IL6, BCL2, S100B, NF1

Products for genes affiliated with Spindle Cell Sarcoma

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Sources for Spindle Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet