MCID: SPN035
MIFTS: 53

Spindle Cell Sarcoma malady

Cancer diseases category

Summaries for Spindle Cell Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

MalaCards: Spindle Cell Sarcoma, also known as sarcoma, spindle cell, is related to sarcoma and kaposi's sarcoma. An important gene associated with Spindle Cell Sarcoma is KRT13 (keratin 13), and among its related pathways are miRNAs involved in DDR and PLK3 signaling events. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lung, and related mouse phenotypes are renal/urinary system and pigmentation.

Disease Ontology:8 A sarcoma that results in cells that are spindle-shaped. they are usually resistant to radiation therapy.

Aliases & Classifications for Spindle Cell Sarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell sarcoma 8 10
sarcoma, spindle cell 60
sarcoma spindle cell 44


External Ids:

Disease Ontology8 DOID:4235
MeSH34 D012509
SNOMED-CT56 9801004
NCIt39 C27005

Related Diseases for Spindle Cell Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to spindle cell sarcoma

Clinical Features for Spindle Cell Sarcoma

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Drugs & Therapeutics for Spindle Cell Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spindle Cell Sarcoma

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Anatomical Context for Spindle Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Sarcoma:

32
Kidney, Skin, Lung, Liver, Endothelial, Heart, Breast, Bone, Prostate, Smooth muscle, Adrenal gland, Spleen

Animal Models for Spindle Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2KRT7
2MP:00011869.9NF1
3MP:00053699.7NF1, TP53
4MP:00036319.0BCL2, OLFM1, NF1
5MP:00053888.9NF1, CDKN1B, IL6, BCL2, TP53
6MP:00107718.9TP53, BCL2, IL6, CDKN1B, S100B, CCNE1
7MP:00020068.8CCNE1, NF1, CDKN1B, IL6, BCL2, TP53
8MP:00053818.7CCNE1, CDKN1B, IL6, KRT8, BCL2, TP53
9MP:00053898.6CCNE1, CDKN1B, OLFM1, BCL2, TP53
10MP:00053918.4VIM, NF1, CDKN1B, IL6, BCL2, TP53
11MP:00053858.2VIM, CCNE1, NF1, CDKN1B, IL6, KRT8
12MP:00053878.0VIM, CCNE1, NF1, CDKN1B, IL6, KRT8
13MP:00053787.9VIM, CCNE1, DSP, NF1, CDKN1B, IL6
14MP:00053847.7VIM, CCNE1, DSP, NF1, CDKN1B, IL6

Publications for Spindle Cell Sarcoma

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50PubMed
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Articles related to Spindle Cell Sarcoma:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. (22951535)
2013
2
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide. (23715844)
2013
3
Primary intimal (spindle cell) sarcoma of the heart: a case report and review of the literature. (23424592)
2013
4
Jejunal undifferentiated spindle cell sarcoma with glossal metastasis. (22313541)
2012
5
Radiation-induced high-grade spindle cell sarcoma of the sternomastoid muscle: a case report. (23250072)
2012
6
Case of the season: primary pulmonary collision tumor consisting of carcinoid and high-grade spindle-cell sarcoma. (21726700)
2011
7
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (21516130)
2011
8
Glypican-3 is expressed in rhabdomyosarcomas but not adult spindle cell and pleomorphic sarcomas. (21493758)
2011
9
Eosinophilic and neutrophilic leukemoid reaction in a woman with spindle cell sarcoma: a case report. (20964813)
2010
10
A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall. (21319519)
2010
11
Spindle cells from acquired immune deficiency syndrome-associated Kaposi's sarcoma lesions express telomerase activity directly relating to the RNA levels of fibroblast growth factor-2. (20162666)
2010
12
Spindle cell sarcoma degeneration of giant cell tumor of the knee, imaged with F-18 FDG PET-CT and Tc-99m MDP bone scan. (20090462)
2010
13
Prolonged survival with left atrial spindle cell sarcoma. (19304772)
2009
14
Primary peritoneal spindle cell sarcoma presented with massive ascites: a case report. (20148470)
2009
15
Recurrence of a laryngeal spindle cell sarcoma with a transformation into a higher grade of malignancy. (19121902)
2009
16
Primary Spindle Cell Sarcoma of the Breast. (20824039)
2008
17
Primary spindle cell sarcoma of the vagina treated with neoadjuvant radiation and pelvic exenteration. (17415115)
2007
18
Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. (15893992)
2005
19
Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma. (15208086)
2004
20
Alpha-chemokine-mediated signal transduction in human Kaposi's sarcoma spindle cells. (15110993)
2004
21
Hyalinizing spindle cell tumor with giant rosettes and low-grade fibromyxoid sarcoma: an immunohistochemical and ultrastructural comparative investigation. (14708726)
2003
22
A gastric carcinosarcoma with neuroendocrine cell differentiation and undifferentiated spindle-shaped sarcoma component possibly progressing from the conventional tubular adenocarcinoma; an immunohistochemical and ultrastructural study. (12536318)
2003
23
Secretion of interleukin-6 and vascular endothelial growth factor by spindle cell sarcoma complicating Castleman's disease (so-called 'vascular neoplasia'). (12015752)
2002
24
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin. (12010367)
2002
25
Identification of syt-ssx fusion transcripts in both epithelial and spindle cell components of biphasic synovial sarcoma in small tissue samples isolated by membrane-based laser microdissection. (11561755)
2001
26
Cutaneous indeterminate cell histiocytosis: a new spindle cell variant resembling dendritic cell sarcoma. (11737523)
2001
27
Syncope in a patient with spindle cell sarcoma of the main pulmonary artery. (11369696)
2001
28
Correlation between clinicopathological features and karyotype in spindle cell sarcomas. A report of 130 cases from the CHAMP study group. (10362810)
1999
29
Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats. (9686439)
1998
30
Phenotype and proliferation characteristics of cultured spindle-shaped cells obtained from normal human skin and lesions of dermatofibroma, Kaposi's sarcoma, and dermatofibrosarcoma protuberans: a comparison with fibroblast and endothelial cells of the dermis. (9438908)
1997
31
Ultrastructural evidence for divergent and alternating differentiations in spindle cell sarcoma xenografts. (9165712)
1997
32
Overexpression of bcl-2 protein in synovial sarcoma: a comparative study of other soft tissue spindle cell sarcomas and an additional analysis by fluorescence in situ hybridization. (8892591)
1996
33
Monophasic spindle cell synovial sarcoma of the head and neck: report of two cases an review of the literature. (8308633)
1994
34
Intraarterial Cisplatin and caffeine with/without Doxorubicin for musculoskeletal high-grade spindle-cell sarcoma. (21607301)
1994
35
The fibroma-like variant of epithelioid sarcoma. A fibrohistiocytic/myoid cell lesion often confused with benign and malignant spindle cell tumors. (1371711)
1992
36
The human progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shaped cells in Kaposi's sarcoma. (2006877)
1991
37
Neonatal colorectal spindle cell sarcoma. (1765926)
1991
38
Postoperative spindle cell nodules (PSCN) resembling sarcomas: an atypical granulation tissue or atypical pyogenic granuloma with exuberant myofibroblastic component? (2091012)
1990
39
Spindle cell sarcoma of the heart in childhood: light microscopic, ultrastructural, and immunohistochemical evidence for smooth muscle, endothelial, and fibroblastic differentiation. (3244601)
1988
40
Atypical fibroxanthoma distinguishable from spindle cell carcinoma in sarcoma-like skin lesions. A clinicopathologic and immunohistochemical study of 21 cases. (2578080)
1985
41
Spindle-cell sarcoma of the equine para-nasal sinuses and nasal chamber. (1129920)
1975
42
Primary spindle-cell sarcoma of the spleen with angiographic demonstration. (4684795)
1973
43
Malignant neurilemoma of the mediastinum. A variant of spindle cell sarcoma. (5788655)
1969
44
Preliminary report on a spindle-cell sarcoma in the Syrian hamster produced by thorotrast. (5969491)
1966
45
Spindle cell sarcoma of the kidney with associated eosinophilia. (13634328)
1959
46
A complex of glioblastoma and spindle-cell sarcoma with pulmonary metastasis. (13582394)
1958
47
Two cases of spindle-cell sarcoma of the rectum. (13281668)
1955
48
Spindle cell sarcoma of the prostate gland: case report. (13053621)
1953
49
Primary spindle-cell sarcoma in a Meckel's diverticulum. (18108697)
1949
50
A Positive Focal Tuberculin Reaction in a Spindle-Cell Sarcoma which Had Perforated the Sclera. (16692490)
1919

Genetic Variations for Spindle Cell Sarcoma

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Expression for genes affiliated with Spindle Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for genes affiliated with Spindle Cell Sarcoma

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37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CCNE1
29.8TP53, CCNE1
3
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9.7TP53, BCL2
4
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9.6TP53, CDKN1B, CCNE1
5
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9.6CCNE1, CDKN1B, TP53
6
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9.5TP53, NF1, CCNE1
79.5BCL2, IL6, CDKN1B
8
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9.5CCNE1, IL6, TP53
99.4NF1, IL6, BCL2
109.3TP53, CDKN1B, NF1, CCNE1
119.2CCNE1, CDKN1B, BCL2, TP53
129.2TP53, BCL2, CDKN1B, CCNE1
13
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9.2TP53, IL6, CDKN1B, CCNE1
149.2TP53, BCL2, CDKN1B, VIM
159.2VIM, KRT7, KRT13, KRT8
169.1VIM, CDKN1B, IL6, TP53
179.1CDKN1B, IL6, BCL2, TP53
188.9VIM, CCNE1, CDKN1B, BCL2, TP53
198.9KRT8, KRT13, KRT7, DSP, VIM
208.9CCNE1, CDKN1B, IL6, BCL2, TP53
218.9CCNE1, CDKN1B, IL6, BCL2, TP53
22
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8.9CCNE1, CDKN1B, IL6, BCL2, TP53
23
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8.0VIM, CCNE1, DSP, NF1, CDKN1B, IL6

Compounds for genes affiliated with Spindle Cell Sarcoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6KRT8
2estrogen4410.6NF1
3vincristine44 49 1112.0MKI67, VIM
4adriamycin449.9KRT8, VIM, BCL2
5reticulin449.8S100B, VIM, KRT7
6mucicarmine449.8VIM, KRT7, S100B
7tanshinone iia449.7TP53, BCL2
8indole-3-carbinol449.7BCL2, CDKN1B, TP53
9triptolide449.7IL6, BCL2, TP53
10troglitazone44 28 59 1112.6IL6, BCL2, KRT13, CDKN1B
11n-(4-hydroxyphenyl)retinamide449.6BCL2, VIM, TP53
12b 723449.6KRT7, S100B, VIM, KRT8
13fludarabine44 1110.5TP53, BCL2, CDKN1B
14cytarabine44 49 1111.5TP53, CDKN1B, BCL2, VIM
15etoposide44 49 59 1112.5CDKN1B, S100B, VIM, BCL2, KRT8
16bortezomib44 1110.5IL6, CDKN1B, TP53, BCL2
17flavopiridol44 1110.5TP53, CDKN1B, BCL2
18dutp449.4MKI67, TP53, BCL2
19paclitaxel44 49 1111.4TP53, S100B, KRT8, BCL2, CDKN1B
20forskolin44 49 1111.4KRT8, CDKN1B, NF1, S100B, VIM
21roscovitine449.3VIM, BCL2, TP53
22bromodeoxyuridine449.3KRT8, CDKN1B, MKI67, S100B, VIM
23cyclophosphamide44 49 1111.3MKI67, CDKN1B, TP53, BCL2
24thymidylate449.2TP53, VIM, MKI67, BCL2
25genistein44 28 59 2 11 2414.2IL6, CDKN1B, KRT8, VIM, BCL2
26tgf beta1449.2CDKN1B, MKI67, DSP, VIM, IL6
27sb 20358044 5910.2VIM, IL6, TP53, BCL2, CDKN1B
28proline449.0KRT13, S100B, TP53, MKI67, VIM
29hematoxylin449.0S100B, VIM, KRT8, KRT7, MKI67
30formaldehyde44 2410.0CDKN1B, MKI67, KRT7, S100B, VIM
31retinoid449.0TP53, BCL2, KRT7, KRT8, VIM
32lactate449.0S100B, MKI67, IL6, KRT8, VIM
33actinomycin d448.9BCL2, TP53, IL6, CDKN1B, VIM, KRT8
34methotrexate44 49 1110.9KRT7, IL6, CDKN1B, MKI67, VIM
35oligonucleotide448.9TP53, BCL2, CDKN1B, KRT8, VIM, NF1
36cisplatin44 49 59 1111.8MKI67, CDKN1B, TP53, BCL2, KRT8
37thymidine44 249.8IL6, TP53, S100B, CDKN1B, MKI67
38tamoxifen44 49 28 1111.8KRT8, CDKN1B, TP53, MKI67, VIM, BCL2
39doxorubicin44 49 1110.8TP53, CDKN1B, MKI67, KRT8, BCL2, VIM
40glycogen44 249.8KRT8, KRT7, VIM, CDKN1B, MKI67, S100B
415fluorouracil448.6CDKN1B, MKI67, BCL2, TP53
42testosterone44 59 11 2411.4VIM, S100B, MKI67, CDKN1B, IL6, KRT8
43arginine448.3TP53, VIM, KRT7, CDKN1B, S100B, NF1
44lipid448.2KRT7, S100B, KRT8, IL6, VIM, NF1
45tyrosine448.0KRT7, KRT8, DSP, NF1, MKI67, CDKN1B
46serine447.7BCL2, KRT8, CDKN1B, MKI67, NF1, DSP
47vegf447.7S100B, KRT7, BCL2, IL6, TP53, CDKN1B
48paraffin447.5CDKN1B, MKI67, KRT13, BCL2, TP53, KRT7
49progesterone44 59 28 11 2411.2S100B, CCNE1, VIM, TP53, BCL2, KRT8
50retinoic acid44 247.9TP53, VIM, KRT7, IL6, KRT8, CDKN1B

GO Terms for genes affiliated with Spindle Cell Sarcoma

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16Gene Ontology
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Cellular components related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT8, KRT13, KRT7
2intermediate filamentGO:0058829.0KRT8, KRT7, DSP, VIM
3cytoplasmGO:0057376.5VIM, S100B, AFAP1L1, NF1, MKI67, CDKN1B

Biological processes related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.0DSP, VIM
2mitotic cell cycle arrestGO:07185010.0CDKN1B, TP53
3B cell lineage commitmentGO:00232610.0TP53, BCL2
4negative regulation of neuroblast proliferationGO:0074069.9NF1, TP53
5regulation of cell-matrix adhesionGO:0019529.9NF1, BCL2
6negative regulation of mitotic cell cycleGO:0459309.9BCL2, CDKN1B
7response to glucocorticoid stimulusGO:0513849.7BCL2, IL6, S100B
8regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
9positive regulation of apoptotic processGO:0430659.3TP53, IL6, NF1, S100B
10negative regulation of cell growthGO:0303089.2TP53, BCL2, CDKN1B
11modulation by virus of host morphology or physiologyGO:0190488.9VIM, KRT7, KRT8, TP53

Molecular functions related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.7TP53, BCL2
2scaffold protein bindingGO:0971109.5VIM, DSP, KRT8
3structural molecule activityGO:0051988.9KRT8, KRT13, KRT7, DSP
4protein bindingGO:0055155.3TP53, VIM, CCNE1, TLE2, S100B, DSP

Products for genes affiliated with Spindle Cell Sarcoma

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Sources for Spindle Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet