MCID: SPN035
MIFTS: 53

Spindle Cell Sarcoma malady

Cancer diseases category

Summaries for Spindle Cell Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

MalaCards: Spindle Cell Sarcoma, also known as sarcoma, spindle cell, is related to sarcoma and kaposi's sarcoma. An important gene associated with Spindle Cell Sarcoma is KRT13 (keratin 13), and among its related pathways are miRNAs involved in DDR and PLK3 signaling events. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lung, and related mouse phenotypes are renal/urinary system and pigmentation.

Disease Ontology:8 A sarcoma that results in cells that are spindle-shaped. they are usually resistant to radiation therapy.

Aliases & Classifications for Spindle Cell Sarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell sarcoma 8 10
sarcoma, spindle cell 60
sarcoma spindle cell 44


External Ids:

Disease Ontology8 DOID:4235
MeSH34 D012509
SNOMED-CT56 9801004
NCIt39 C27005

Related Diseases for Spindle Cell Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to spindle cell sarcoma

Clinical Features for Spindle Cell Sarcoma

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Drugs & Therapeutics for Spindle Cell Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spindle Cell Sarcoma

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Anatomical Context for Spindle Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Sarcoma:

32
Kidney, Skin, Lung, Liver, Endothelial, Breast, Heart, Bone, Prostate, Spleen, Smooth muscle, Adrenal gland

Animal Models for Spindle Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2KRT7
2MP:00011869.9NF1
3MP:00053699.7NF1, TP53
4MP:00036319.0BCL2, OLFM1, NF1
5MP:00053888.9NF1, CDKN1B, IL6, BCL2, TP53
6MP:00107718.9TP53, BCL2, IL6, CDKN1B, S100B, CCNE1
7MP:00020068.8CCNE1, NF1, CDKN1B, IL6, BCL2, TP53
8MP:00053818.7CCNE1, CDKN1B, IL6, KRT8, BCL2, TP53
9MP:00053898.6CCNE1, CDKN1B, OLFM1, BCL2, TP53
10MP:00053918.4VIM, NF1, CDKN1B, IL6, BCL2, TP53
11MP:00053858.2VIM, CCNE1, NF1, CDKN1B, IL6, KRT8
12MP:00053878.0VIM, CCNE1, NF1, CDKN1B, IL6, KRT8
13MP:00053787.9VIM, CCNE1, DSP, NF1, CDKN1B, IL6
14MP:00053847.7VIM, CCNE1, DSP, NF1, CDKN1B, IL6

Publications for Spindle Cell Sarcoma

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50PubMed
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Articles related to Spindle Cell Sarcoma:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
Expression of PROX-1 in oral Kaposi's sarcoma spindle cells. (23763431)
2014
2
Recurrent cardiac intimal (spindle cell) sarcoma of the left atrium. (21924626)
2013
3
Left atrial spindle cell sarcoma - case report. (22929830)
2012
4
Spindle cell sarcoma of the maxillary antrum. (23741844)
2012
5
Cutaneous clear cell sarcoma: report of three cases of a potentially underestimated mimicker of spindle cell melanoma. (22421295)
2012
6
Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma. (22606579)
2011
7
Spindle cell sarcoma of esophagus: a rare case presentation. (20479559)
2010
8
Anaplastic renal spindle cell sarcoma in a dog. (20626788)
2010
9
Radiation-induced spindle cell sarcoma: a rare case report. (19884729)
2009
10
Re: Spindle cell sarcoma of the profundua femoris vein, mimicking deep venous thrombosis. (18625364)
2008
11
Marginal excision of low-grade spindle cell sarcoma of canine extremities: 35 dogs (1996-2006). (18986313)
2008
12
Ureteral spindle cell sarcoma in a dog. (17850279)
2007
13
A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma. (17721327)
2007
14
Images in cardiovascular medicine. Contrast-enhanced echocardiography in spindle cell sarcoma of the pericardium. (17372181)
2007
15
What is your diagnosis? Spindle cell sarcoma . (16426184)
2006
16
Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. (15661546)
2005
17
A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. (15467709)
2005
18
Spindle cell sarcoma of the pericardium: a case report. (15016051)
2004
19
A 71-year-old man with spindle-cell neoplasm of unknown origin: a difficult-to-diagnose clear-cell sarcoma. (15347490)
2004
20
The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27(Kip1) and cyclin E. (12824885)
2003
21
Coamplification of 12p11 and 12q13 approximately q22 in multiple ring chromosomes in a spindle cell sarcoma resolved by novel multicolor fluorescence in situ hybridization analysis. (12547157)
2002
22
Spindle cell sarcoma with neuroepithelial [correction of neuroectodermal] differentiation. (11260312)
2001
23
Detection of SYT-SSX fusion transcripts in both epithelial and spindle cell areas of biphasic synovial sarcoma using laser capture microdissection. (10889911)
2000
24
Undifferentiated spindle-cell sarcoma of the chest wall with vascular endothelial growth factor expression: report of a case. (11039713)
2000
25
Synovial sarcoma specific translocation associated with both epithelial and spindle cell components. (10404078)
1999
26
Abdominal spindle cell sarcoma of probable myofibroblastic origin in a horse. (10353361)
1999
27
Spindle cell sarcoma of the kidney with ganglionic elements (malignant ectomesenchymoma) associated with chromosomal abnormalities and a review of the literature. (9544170)
1998
28
Identification of interleukin-1 and platelet-derived growth factor-B as major mitogens for the spindle cells of Kaposi's sarcoma: a combined in vitro and in vivo analysis. (7761101)
1995
29
Human immunodeficiency virus-associated oral Kaposi's sarcoma. A heterogeneous cell population dominated by spindle-shaped endothelial cells. (8100400)
1993
30
Small round and spindle cell sarcoma with neuronal differentiation and oncocyte-like features of the thoracic wall: a case report with histological, immunohistochemical and ultrastructural examinations. (8291451)
1993
31
Neonatal colorectal spindle cell sarcoma. (1501050)
1992
32
Echocardiographic demonstration of mitral block caused by left atrial spindle cell sarcoma. (1729836)
1992
33
Spindle cell ploidy and proliferation in endemic and epidemic African Kaposi's sarcoma. (1356389)
1992
34
Kaposi's sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo. (1457189)
1992
35
Keratin subsets in spindle cell sarcomas. Keratins are widespread but synovial sarcoma contains a distinctive keratin polypeptide pattern and desmoplakins. (1704194)
1991
36
Spindle cell sarcoma in the kidney of a dog. (2032906)
1991
37
High-dose interferon-beta in treatment of spindle-cell sarcoma of breast. (2145946)
1990
38
Spindle cell sarcoma showing concentration of Tc-99m sodium pertechnetate and Tc-99m (V) DMSA. (2155729)
1990
39
Three types of spindle cell tumors of the pleura. Fibroma, sarcoma, and sarcomatoid mesothelioma. (3421411)
1988
40
Spindle cell sarcoma mimicking traumatic lung cysts. (3996425)
1985
41
Monophasic synovial sarcoma of spindle-cell type. Epithelial differentiation as revealed by ultrastructural features, content of prekeratin and binding of peanut agglutinin. (6196906)
1983
42
Spindle cell sarcoma of scrotum. (7445295)
1980
43
Late reappearance of spindle cell sarcoma of the thigh: a case report. (6075633)
1967
44
SPONTANEOUS hypoglycemia with abdominal spindle-cell sarcoma. (13857105)
1960
45
Spindle cell sarcoma of the vagina; a case treated by radium implant. (13320234)
1956
46
Primary spindle-cell sarcoma in the right auricle. (14772664)
1950
47
Spindle cell sarcoma of the hard palate; report of case. (18117042)
1949
48
A case of spindle-cell sarcoma of the stomach. (18921023)
1947
49
Spindle-cell sarcoma of the chest wall. (21011394)
1945
50
SPINDLE CELL SARCOMA OF THE PROSTATE. (20316150)
1927

Genetic Variations for Spindle Cell Sarcoma

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Expression for genes affiliated with Spindle Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for genes affiliated with Spindle Cell Sarcoma

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37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CCNE1
29.8TP53, CCNE1
3
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9.7TP53, BCL2
4
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9.6TP53, CDKN1B, CCNE1
5
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9.6CCNE1, CDKN1B, TP53
6
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9.5TP53, NF1, CCNE1
79.5BCL2, IL6, CDKN1B
8
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9.5CCNE1, IL6, TP53
99.4NF1, IL6, BCL2
109.3TP53, CDKN1B, NF1, CCNE1
119.2CCNE1, CDKN1B, BCL2, TP53
129.2TP53, BCL2, CDKN1B, CCNE1
13
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9.2TP53, IL6, CDKN1B, CCNE1
149.2TP53, BCL2, CDKN1B, VIM
159.2VIM, KRT7, KRT13, KRT8
169.1VIM, CDKN1B, IL6, TP53
179.1CDKN1B, IL6, BCL2, TP53
188.9VIM, CCNE1, CDKN1B, BCL2, TP53
198.9KRT8, KRT13, KRT7, DSP, VIM
208.9CCNE1, CDKN1B, IL6, BCL2, TP53
218.9CCNE1, CDKN1B, IL6, BCL2, TP53
22
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8.9CCNE1, CDKN1B, IL6, BCL2, TP53
23
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8.0VIM, CCNE1, DSP, NF1, CDKN1B, IL6

Compounds for genes affiliated with Spindle Cell Sarcoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6KRT8
2estrogen4410.6NF1
3vincristine44 49 1112.0MKI67, VIM
4adriamycin449.9VIM, KRT8, BCL2
5reticulin449.8KRT7, S100B, VIM
6mucicarmine449.8VIM, S100B, KRT7
7tanshinone iia449.7TP53, BCL2
8indole-3-carbinol449.7TP53, BCL2, CDKN1B
9triptolide449.7TP53, BCL2, IL6
10troglitazone44 28 59 1112.6BCL2, KRT13, IL6, CDKN1B
11n-(4-hydroxyphenyl)retinamide449.6VIM, BCL2, TP53
12b 723449.6KRT8, KRT7, S100B, VIM
13fludarabine44 1110.5CDKN1B, BCL2, TP53
14cytarabine44 49 1111.5VIM, CDKN1B, BCL2, TP53
15etoposide44 49 59 1112.5VIM, S100B, CDKN1B, KRT8, BCL2
16bortezomib44 1110.5TP53, BCL2, IL6, CDKN1B
17flavopiridol44 1110.5TP53, BCL2, CDKN1B
18dutp449.4TP53, BCL2, MKI67
19paclitaxel44 49 1111.4S100B, CDKN1B, KRT8, BCL2, TP53
20forskolin44 49 1111.4VIM, S100B, NF1, CDKN1B, KRT8
21roscovitine449.3TP53, BCL2, VIM
22bromodeoxyuridine449.3VIM, S100B, MKI67, CDKN1B, KRT8
23cyclophosphamide44 49 1111.3MKI67, CDKN1B, BCL2, TP53
24thymidylate449.2TP53, BCL2, MKI67, VIM
25genistein44 28 59 2 11 2414.2BCL2, KRT8, IL6, CDKN1B, VIM
26tgf beta1449.2VIM, DSP, MKI67, CDKN1B, IL6
27sb 20358044 5910.2TP53, BCL2, IL6, CDKN1B, VIM
28proline449.0VIM, S100B, MKI67, KRT13, TP53
29hematoxylin449.0VIM, S100B, MKI67, KRT7, KRT8
30formaldehyde44 2410.0VIM, S100B, MKI67, CDKN1B, KRT7
31retinoid449.0VIM, KRT7, KRT8, BCL2, TP53
32lactate449.0VIM, S100B, MKI67, IL6, KRT8
33actinomycin d448.9VIM, CDKN1B, IL6, KRT8, BCL2, TP53
34methotrexate44 49 1110.9VIM, MKI67, CDKN1B, IL6, KRT7
35oligonucleotide448.9VIM, NF1, CDKN1B, KRT8, BCL2, TP53
36cisplatin44 49 59 1111.8TP53, BCL2, KRT8, CDKN1B, MKI67
37thymidine44 249.8TP53, IL6, CDKN1B, MKI67, S100B
38tamoxifen44 49 28 1111.8VIM, MKI67, CDKN1B, KRT8, BCL2, TP53
39doxorubicin44 49 1110.8VIM, MKI67, CDKN1B, KRT8, BCL2, TP53
40glycogen44 249.8VIM, S100B, MKI67, CDKN1B, KRT7, KRT8
415fluorouracil448.6MKI67, CDKN1B, BCL2, TP53
42testosterone44 59 11 2411.4VIM, S100B, MKI67, CDKN1B, IL6, KRT7
43arginine448.3VIM, S100B, NF1, MKI67, CDKN1B, KRT7
44lipid448.2VIM, S100B, NF1, MKI67, IL6, KRT7
45tyrosine448.0S100B, DSP, NF1, MKI67, CDKN1B, IL6
46serine447.7VIM, CCNE1, S100B, DSP, NF1, MKI67
47vegf447.7VIM, S100B, MKI67, CDKN1B, IL6, KRT7
48paraffin447.5MKI67, NF1, S100B, VIM, CDKN1B, KRT7
49progesterone44 59 28 11 2411.2TP53, VIM, CCNE1, S100B, DSP, NF1
50retinoic acid44 247.9MKI67, NF1, DSP, S100B, VIM, CDKN1B

GO Terms for genes affiliated with Spindle Cell Sarcoma

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16Gene Ontology
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Cellular components related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT8, KRT13, KRT7
2intermediate filamentGO:0058829.0KRT8, KRT7, DSP, VIM
3cytoplasmGO:0057376.5VIM, S100B, AFAP1L1, NF1, MKI67, CDKN1B

Biological processes related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.0DSP, VIM
2mitotic cell cycle arrestGO:07185010.0CDKN1B, TP53
3B cell lineage commitmentGO:00232610.0TP53, BCL2
4negative regulation of neuroblast proliferationGO:0074069.9NF1, TP53
5regulation of cell-matrix adhesionGO:0019529.9NF1, BCL2
6negative regulation of mitotic cell cycleGO:0459309.9BCL2, CDKN1B
7response to glucocorticoid stimulusGO:0513849.7BCL2, IL6, S100B
8regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
9positive regulation of apoptotic processGO:0430659.3TP53, IL6, NF1, S100B
10negative regulation of cell growthGO:0303089.2TP53, BCL2, CDKN1B
11modulation by virus of host morphology or physiologyGO:0190488.9VIM, KRT7, KRT8, TP53

Molecular functions related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.7TP53, BCL2
2scaffold protein bindingGO:0971109.5VIM, DSP, KRT8
3structural molecule activityGO:0051988.9KRT8, KRT13, KRT7, DSP
4protein bindingGO:0055155.3TP53, VIM, CCNE1, TLE2, S100B, DSP

Products for genes affiliated with Spindle Cell Sarcoma

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Spindle Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet