Aliases & Classifications for Spindle Cell Sarcoma

MalaCards integrated aliases for Spindle Cell Sarcoma:

Name: Spindle Cell Sarcoma 12 14
Sarcoma 41 69
Sarcoma, Spindle Cell 69
Sarcoma Spindle Cell 51
Sarcoma - Category 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4235
MeSH 41 D012509
NCIt 46 C27005
SNOMED-CT 64 9801004

Summaries for Spindle Cell Sarcoma

Disease Ontology : 12 A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy.

MalaCards based summary : Spindle Cell Sarcoma, also known as sarcoma, is related to ewing sarcoma and sarcoma, synovial. An important gene associated with Spindle Cell Sarcoma is VIM (Vimentin), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Cytoskeletal Signaling. The drugs Doxil and Fusilev have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and kidney, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and cardiovascular system

Wikipedia : 72 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

Related Diseases for Spindle Cell Sarcoma

Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 32.9 DES MDM2 S100B VEGFA VIM
2 sarcoma, synovial 31.2 DES KRT7 MDM2 MUC1 VIM
3 soft tissue sarcoma 30.2 MDM2 VEGFA
4 fibrosarcoma 30.0 DES NTRK3 VIM
5 fibrous histiocytoma 29.6 ACTC1 DES VIM
6 giant cell tumor 29.6 DES MUC1 VIM
7 fasciitis 28.7 ACTC1 DES MUC1 VIM
8 kaposi sarcoma 12.6
9 spindle cell synovial sarcoma 11.3
10 sarcoma 10.8
11 retroperitoneal fibrosis 10.5 MDM2 VIM
12 infiltrating angiolipoma 10.5 MDM2 VEGFA
13 adenoid squamous cell carcinoma 10.4 KRT7 VIM
14 papillary adenoma 10.4 KRT7 VIM
15 skin glomus tumor 10.4 DES VIM
16 infantile digital fibromatosis 10.4 DES VIM
17 extraosseous osteosarcoma 10.4 KRT7 MDM2
18 lymphangiomatosis 10.4 DES VIM
19 primitive neuroectodermal tumor of the cervix uteri 10.4 DES VIM
20 medulloepithelioma 10.4 KRT7 VIM
21 metanephric adenoma 10.4 KRT7 VIM
22 adenomatoid tumor 10.4 KRT7 VIM
23 epulis 10.4 DES VIM
24 mesenchymoma 10.4 DES MDM2
25 fibrolamellar carcinoma 10.4 KRT7 VIM
26 chondroid lipoma 10.4 KRT7 MDM2
27 endocervical adenocarcinoma 10.4 KRT7 VIM
28 hydromyelia 10.4 S100B VIM
29 pancreatic serous cystadenoma 10.4 KRT7 VEGFA
30 bednar tumor 10.4 S100B VIM
31 malignant fibrous histiocytoma of bone 10.4 DES MDM2
32 peliosis hepatis 10.4 VEGFA VIM
33 primary hepatic neuroendocrine carcinoma 10.4 S100B VIM
34 endodermal sinus tumor 10.4 KRT7 VIM
35 renal pelvis carcinoma 10.4 KRT7 VEGFA
36 collecting duct carcinoma 10.3 KRT7 VIM
37 ovarian benign neoplasm 10.3 DES KRT7
38 congenital epulis 10.3 DES VIM
39 horner's syndrome 10.3 DES KRT7
40 malignant peritoneal mesothelioma 10.3 MUC1 VIM
41 papillary tumor of the pineal region 10.3 MUC1 VIM
42 clear cell meningioma 10.3 MUC1 VIM
43 endometrial mucinous adenocarcinoma 10.3 MUC1 VIM
44 dupuytren contracture 10.3 DES VEGFA
45 sarcomatoid mesothelioma 10.3 MUC1 VIM
46 malignant triton tumor 10.2 DES S100B
47 lipomatosis, multiple 10.2 DES MDM2
48 sertoli cell tumor 10.2 MUC1 VIM
49 chondroid chordoma 10.2 MUC1 VIM
50 uterine sarcoma 10.2 DES MDM2

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to Spindle Cell Sarcoma

Symptoms & Phenotypes for Spindle Cell Sarcoma

GenomeRNAi Phenotypes related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.92 MUC1 NTRK3 VEGFA VIM

MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 NTRK3 VEGFA VIM ACTC1 DES KMT2B
2 cellular MP:0005384 9.7 MDM2 VEGFA VIM ACTC1 DES KMT2B
3 homeostasis/metabolism MP:0005376 9.56 MDM2 S100B VEGFA VIM ACTC1 DES
4 normal MP:0002873 9.1 NTRK3 S100B VEGFA ACTC1 KMT2B MDM2

Drugs & Therapeutics for Spindle Cell Sarcoma

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Doxil 17 45 DOXORUBICIN HYDROCHLORIDE Alza June 1999
2
Fusilev 17 LEVOLEUCOVORIN CALCIUM Spectrum Pharmaceuticals March of 2008
3
Intron A 17 45 INTERFERON ALFA-2B Schering-Plough December 1997/ December 1995/ March 1997
4
Taxol 17 45 PACLITAXEL Bristol-Myers Squibb August 1997
5
Votrient 17 45 PAZOPANIB HYDROCHLORIDE GlaxoSmithKline April 2012/ October of 2009

Drugs for Spindle Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
2
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
5
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
6
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
9
Doxil Approved June 1999 Phase 1, Phase 2 31703
10 Anti-Bacterial Agents Phase 1, Phase 2
11 Antibiotics, Antitubercular Phase 1, Phase 2
12 Antifungal Agents Phase 1, Phase 2
13 Anti-Infective Agents Phase 1, Phase 2
14 Immunosuppressive Agents Phase 1, Phase 2
15 Topoisomerase Inhibitors Phase 1, Phase 2
16 Antimetabolites Phase 2
17 Antimetabolites, Antineoplastic Phase 2
18 Antirheumatic Agents Phase 2
19 Dermatologic Agents Phase 2
20 Folic Acid Antagonists Phase 2
21 Nucleic Acid Synthesis Inhibitors Phase 2
22 Vitamin B Complex Phase 2
23 Antidotes Phase 2
24 Hematinics Phase 2
25 Micronutrients Phase 2
26 Protective Agents Phase 2
27 Trace Elements Phase 2
28 Vitamins Phase 2
29 Folate Nutraceutical Phase 2
30 Vitamin B9 Nutraceutical Phase 2
31
Cisplatin Approved 15663-27-1 2767 441203 84093
32
Ifosfamide Approved 3778-73-2 3690
33
Mechlorethamine Approved, Investigational 51-75-2 4033
34 Alkylating Agents
35 Isophosphamide mustard 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Completed NCT00949325 Phase 1, Phase 2 temsirolimus (Torisel) plus liposomal doxorubicin (Doxil)
2 Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays? Terminated NCT02022358 Phase 2 Glucarpidase;Methotrexate;Folinic Acid
3 European Study in Bone Sarcoma Patients Over 40 Years Completed NCT02986503 Doxorubicin+cisplatin+ifosfamide;Doxorubicin+cisplatin+ifosfamide+methotrexate

Search NIH Clinical Center for Spindle Cell Sarcoma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: sarcoma

Genetic Tests for Spindle Cell Sarcoma

Anatomical Context for Spindle Cell Sarcoma

MalaCards organs/tissues related to Spindle Cell Sarcoma:

38
Lung, Liver, Kidney, Skin, Endothelial, Bone, T Cells

Publications for Spindle Cell Sarcoma

Articles related to Spindle Cell Sarcoma:

(show top 50) (show all 140)
# Title Authors Year
1
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma. ( 29306021 )
2018
2
Spindle Cell Sarcoma of the Iliac Vein on 18 F-FDG PET/CT. ( 28134693 )
2017
3
Unusual case of spindle cell sarcoma metastases to right ventricle: a case report and a literature review. ( 28936438 )
2017
4
Oral Spindle Cell Sarcoma: A Rare Case Report and Review of Literature. ( 28571292 )
2017
5
Intimal spindle cell sarcoma masquerading as adult-onset symptomatic pulmonic stenosis: a case report and review of the literature. ( 29084562 )
2017
6
Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas: Expanding the Genetic Spectrum of Tumors With Overlapping Features With Infantile Fibrosarcoma. ( 28877062 )
2017
7
Surgical Management of Primary Spindle Cell Sarcoma of Prostate. ( 28411101 )
2017
8
TFG-MET fusion in an infantile spindle cell sarcoma with neural features. ( 28510278 )
2017
9
Spindle-cell sarcoma involving the major pulmonary arteries. ( 28670068 )
2017
10
High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. ( 28176365 )
2017
11
Post-irradiation vaginal spindle cell sarcoma. ( 29154376 )
2017
12
Spindle cell sarcoma of the mitral valve: a rare indication for mitral valve replacement. ( 29029000 )
2017
13
Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase. ( 29143983 )
2017
14
Gemcitabine and docetaxel in relapsed and unresectable high-grade osteosarcoma and spindle cell sarcoma of bone. ( 27098543 )
2016
15
Direct Tumor Embolization of Sinonasal Unclassified Spindle Cell Sarcoma with Onyx. ( 27652195 )
2016
16
Right atrial spindle cell sarcoma as a rare cause of tricuspid stenosis. ( 27436036 )
2016
17
Spindle Cell Sarcoma Presenting as Pancoast Syndrome. ( 27504558 )
2016
18
Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. ( 26863915 )
2016
19
Primary spindle cell sarcoma of the prostate and (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings. ( 25657562 )
2015
20
Intimal (spindle cell) sarcoma of the left atrium presenting with abnormal neurological examination. ( 26483389 )
2015
21
A spindle cell sarcoma of liver supplied by internal mammary artery. ( 25533497 )
2015
22
Spindle cell sarcoma of the left atrium: an extremely rare and challenging tumour often masquerading as left atrial myxoma. ( 25547565 )
2015
23
CT Imaging Findings of Metastatic Spindle Cell Sarcoma of Prostate: A Case Report and Review of the Literature. ( 26180501 )
2015
24
Primary undifferentiated spindle cell sarcoma of the lung with metastasis to bone - A rare clinical entity with even rarer clinical course. ( 26853426 )
2015
25
Delayed diagnosis of spindle cell sarcoma presenting as a large mass on the back. ( 26194416 )
2015
26
High-grade spindle cell sarcoma of the heart: a case report and review of literature. ( 25888133 )
2015
27
A Unilateral Hemothorax as a Presenting Manifestation of Mediastinal Spindle Cell Sarcoma. ( 25416071 )
2015
28
Spindle cell sarcoma of pulmonary artery mimicking thromboembolism with lung metastasis detected in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. ( 25400365 )
2014
29
Several fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplification. ( 25176350 )
2014
30
Transthoracic echocardiographic assessment of spindle cell sarcoma of the pulmonary artery in a child. ( 24606227 )
2014
31
Primary Intimal (Spindle Cell) Sarcoma of the Left Atrium. ( 25196496 )
2014
32
Spindle cell sarcoma of thyroid: a case report. ( 25767348 )
2014
33
Metastatic Undifferentiated Spindle Cell Sarcoma of the Thyroid Gland Evaluated by 18F-FDG PET/CT. ( 25140545 )
2014
34
Spindle cell sarcoma of the mitral valve: an unusual cause of acute coronary syndrome in a child. ( 25282213 )
2014
35
Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child. ( 25139254 )
2014
36
Primary spindle cell sarcoma of the breast masquerading as necrotizing fasciitis. ( 24876317 )
2014
37
Spindle Cell Sarcoma of the Vulva With Myofibroblastic Differentiation. ( 25062403 )
2014
38
Recurrent cardiac intimal (spindle cell) sarcoma of the left atrium. ( 21924626 )
2013
39
An unusually large spindle cell sarcoma of the tongue in a male child. ( 24669028 )
2013
40
Primary intimal (spindle cell) sarcoma of the heart: a case report and review of the literature. ( 23424592 )
2013
41
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. ( 22951535 )
2013
42
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide. ( 23715844 )
2013
43
Radiation-induced high-grade spindle cell sarcoma of the sternomastoid muscle: a case report. ( 23250072 )
2012
44
Jejunal undifferentiated spindle cell sarcoma with glossal metastasis. ( 22313541 )
2012
45
Left atrial spindle cell sarcoma - case report. ( 22929830 )
2012
46
Spindle cell sarcoma of the maxillary antrum. ( 23741844 )
2012
47
Primary pericardial spindle cell sarcoma mimicking left main coronary artery disease. ( 22219472 )
2012
48
Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. ( 23129168 )
2012
49
Case of the season: primary pulmonary collision tumor consisting of carcinoid and high-grade spindle-cell sarcoma. ( 21726700 )
2011
50
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. ( 21516130 )
2011

Variations for Spindle Cell Sarcoma

ClinVar genetic disease variations for Spindle Cell Sarcoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TP53 NM_000546.5(TP53): c.743G> A (p.Arg248Gln) single nucleotide variant Pathogenic/Likely pathogenic rs11540652 GRCh37 Chromosome 17, 7577538: 7577538
2 PIK3CA NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys) single nucleotide variant Pathogenic/Likely pathogenic rs104886003 GRCh37 Chromosome 3, 178936091: 178936091

Expression for Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for Spindle Cell Sarcoma

Pathways related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.55 MUC1 VEGFA VIM
2 11.51 ACTC1 DES KRT7 MUC1 VIM
3
Show member pathways
11.47 DES KRT7 VIM
4 11.23 S100B VEGFA VIM
5 10.99 ACTC1 DES VIM

GO Terms for Spindle Cell Sarcoma

Cellular components related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.28 ACTC1 DES KRT7 MDM2 MUC1 NTRK3
2 intermediate filament GO:0005882 9.13 DES KRT7 VIM

Biological processes related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.67 MDM2 NTRK3 S100B VEGFA
2 cellular response to hypoxia GO:0071456 9.33 MDM2 S100B VEGFA
3 intermediate filament organization GO:0045109 9.32 DES VIM
4 positive regulation of positive chemotaxis GO:0050927 9.26 NTRK3 VEGFA
5 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
6 positive regulation of gene expression GO:0010628 9.02 ACTC1 MDM2 NTRK3 VEGFA VIM

Molecular functions related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 DES MDM2 S100B VEGFA VIM
2 p53 binding GO:0002039 8.8 MDM2 MUC1 NTRK3

Sources for Spindle Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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