MCID: SPN035
MIFTS: 48

Spindle Cell Sarcoma malady

Cancer diseases category

Summaries for Spindle Cell Sarcoma

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

MalaCards: Spindle Cell Sarcoma, also known as sarcoma, spindle cell, is related to sarcoma and synovial sarcoma. An important gene associated with Spindle Cell Sarcoma is KRT13 (keratin 13), and among its related pathways are Cytoskeletal Signaling and ATF-2 transcription factor network. The compounds olopatadine and reticulin have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and skin, and related mouse phenotypes are renal/urinary system and integument.

Disease Ontology:9 A sarcoma that results in cells that are spindle-shaped. they are usually resistant to radiation therapy.

Aliases & Classifications for Spindle Cell Sarcoma

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell sarcoma 9 11
sarcoma, spindle cell 63
sarcoma spindle cell 46


External Ids:

Disease Ontology9 DOID:4235
NCIt41 C27005
SNOMED-CT59 9801004
MeSH36 D012509

Related Diseases for Spindle Cell Sarcoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7DSP, S100B, NF1, KRT8
2synovial sarcoma30.4BCL2, S100B, NF1, KRT8, KRT7, KRT13
3cholangiocarcinoma30.3KRT7, KRT8
4kaposi's sarcoma10.5
5venous thrombosis10.4
6endotheliitis10.4
7spindle cell synovial sarcoma10.3
8fibrous histiocytoma10.3
9fibrosarcoma10.3
10hepatitis10.3
11histiocytoma10.3
12osteosarcoma10.3
13prostatitis10.3
14coronary artery disease10.2
15meckel's diverticulum10.2
16neuronitis10.2
17ectomesenchymoma10.2
18hypoglycemia10.2
19leukemoid reaction10.2
20neurofibrosarcoma10.2
21phaeochromocytoma10.2
22artery disease10.2
23eosinophilia10.2
24giant cell tumor10.2
25laryngitis10.2
26peritonitis10.2
27seminoma10.2
28castleman's disease10.2
29syncope10.2
30sinusitis10.2
31elastofibroma dorsi10.2
32leopard syndrome10.1DSP
33ovarian brenner tumor10.1KRT7, KRT13
34sex cord-gonadal stromal tumor10.1KRT7, S100B
35malignant mixed mullerian tumor10.1S100B, KRT7
36mucoepidermoid carcinoma10.1KRT7, KRT13
37perineurioma10.1S100B, DSP
38papilloma10.1KRT13
39leukoplakia10.1KRT8, KRT13
40hemangioblastoma10.1S100B, KRT8
41epithelioid sarcoma10.1KRT7, KRT8
42pancreatic ductal carcinoma10.1KRT7, KRT8
43cervical adenocarcinoma10.1KRT7, KRT8
44abrikosov's tumor10.1KRT8, KRT7
45adenosquamous carcinoma10.1KRT8, KRT7
46malignant peripheral nerve sheath tumor10.1S100B, NF1
47adenoameloblastoma10.1KRT7, KRT8
48gallbladder cancer10.0KRT7, KRT8
49neurofibroma10.0NF1, S100B
50endometrial carcinoma10.0BCL2, KRT7

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to spindle cell sarcoma

Symptoms for Spindle Cell Sarcoma

About this section

Drugs & Therapeutics for Spindle Cell Sarcoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spindle Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Spindle Cell Sarcoma

Search NIH Clinical Center for Spindle Cell Sarcoma

Search CenterWatch for Spindle Cell Sarcoma

Genetic Tests for Spindle Cell Sarcoma

About this section

Anatomical Context for Spindle Cell Sarcoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Spindle Cell Sarcoma:

34
Kidney, Lung, Skin, Liver, Endothelial, Heart, Bone, Breast, Prostate, Spleen, Smooth muscle, Adrenal gland

Animal Models for Spindle Cell Sarcoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6KRT7, NF1, BCL2, IL6
2MP:00107718.1NF1, S100B, BCL2, IL6, DSP

Publications for Spindle Cell Sarcoma

About this section
Sources:
53PubMed
See all sources

Articles related to Spindle Cell Sarcoma:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. (22951535)
2013
2
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide. (23715844)
2013
3
Recurrent cardiac intimal (spindle cell) sarcoma of the left atrium. (21924626)
2013
4
Primary intimal (spindle cell) sarcoma of the heart: a case report and review of the literature. (23424592)
2013
5
Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. (23129168)
2012
6
Primary pericardial spindle cell sarcoma mimicking left main coronary artery disease. (22219472)
2012
7
Case of the season: primary pulmonary collision tumor consisting of carcinoid and high-grade spindle-cell sarcoma. (21726700)
2011
8
Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (21516130)
2011
9
Eosinophilic and neutrophilic leukemoid reaction in a woman with spindle cell sarcoma: a case report. (20964813)
2010
10
A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall. (21319519)
2010
11
High-grade spindle cell sarcoma arising in rhytidectomy scar: a case report. (19717353)
2010
12
Well-differentiated extraskeletal osteosarcoma arising from the retroperitoneum that recurred as anaplastic spindle cell sarcoma. (20224645)
2010
13
Prolonged survival with left atrial spindle cell sarcoma. (19304772)
2009
14
Primary peritoneal spindle cell sarcoma presented with massive ascites: a case report. (20148470)
2009
15
Recurrence of a laryngeal spindle cell sarcoma with a transformation into a higher grade of malignancy. (19121902)
2009
16
Radiation-induced spindle cell sarcoma: a rare case report. (19884729)
2009
17
Re: Spindle cell sarcoma of the profundua femoris vein, mimicking deep venous thrombosis. (18625364)
2008
18
Cardioembolic stroke in a patient with spindle cell sarcoma of the left atrium. (17400125)
2007
19
Primary spindle cell sarcoma of the vagina treated with neoadjuvant radiation and pelvic exenteration. (17415115)
2007
20
Ureteral spindle cell sarcoma in a dog. (17850279)
2007
21
What is your diagnosis? Spindle cell sarcoma . (16426184)
2006
22
Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. (15893992)
2005
23
Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. (15661546)
2005
24
Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma. (15208086)
2004
25
The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27(Kip1) and cyclin E. (12824885)
2003
26
Coamplification of 12p11 and 12q13 approximately q22 in multiple ring chromosomes in a spindle cell sarcoma resolved by novel multicolor fluorescence in situ hybridization analysis. (12547157)
2002
27
Successful treatment of spindle cell sarcoma of the sella turcica. Case report. (12507071)
2002
28
Spindle cell sarcoma with neuroepithelial [correction of neuroectodermal] differentiation. (11260312)
2001
29
Spindle cell sarcoma of the kidney with ganglionic elements (malignant ectomesenchymoma) associated with chromosomal abnormalities and a review of the literature. (9544170)
1998
30
Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats. (9686439)
1998
31
Predictive value of proliferation-related markers, p53, and DNA ploidy for survival in patients with soft tissue spindle-cell sarcomas. (8878024)
1996
32
Combined spindle cell sarcoma/phaeochromocytoma of the adrenal. (8314241)
1993
33
Neonatal colorectal spindle cell sarcoma. (1501050)
1992
34
Spindle-cell sarcoma of the hand may present as a benign recurrent nodule. (1544980)
1992
35
Neonatal colorectal spindle cell sarcoma. (1765926)
1991
36
High-dose interferon-beta in treatment of spindle-cell sarcoma of breast. (2145946)
1990
37
Spindle cell sarcoma showing concentration of Tc-99m sodium pertechnetate and Tc-99m (V) DMSA. (2155729)
1990
38
Spindle-cell sarcoma in patients who have osteochondromatosis. A report of two cases. (3263374)
1988
39
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
40
Spindle cell sarcoma of scrotum. (7445295)
1980
41
Spindle cell sarcoma of the pulmonary trunk: a case report with histochemistry and electron microscopy. (469655)
1979
42
Late reappearance of spindle cell sarcoma of the thigh: a case report. (6075633)
1967
43
Preliminary report on a spindle-cell sarcoma in the Syrian hamster produced by thorotrast. (5969491)
1966
44
BILATERAL TESTICULAR TUMORS: SPINDLE CELL SARCOMA AND SEMINOMA; CASE REPORT. (14044197)
1963
45
SPONTANEOUS hypoglycemia with abdominal spindle-cell sarcoma. (13857105)
1960
46
Spindle cell sarcoma of the kidney with associated eosinophilia. (13634328)
1959
47
Two cases of spindle-cell sarcoma of the rectum. (13281668)
1955
48
Spindle cell sarcoma of the hard palate; report of case. (18117042)
1949
49
A case of spindle-cell sarcoma of the stomach. (18921023)
1947
50
SPINDLE CELL SARCOMA OF THE PROSTATE. (20316150)
1927

Variations for Spindle Cell Sarcoma

About this section

Expression for genes affiliated with Spindle Cell Sarcoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for genes affiliated with Spindle Cell Sarcoma

About this section
Sources:
51PathCards, 5Cell Signaling Technology, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN
See all sources

Pathways related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3KRT8, KRT7, KRT13
29.1NF1, BCL2, IL6
38.9KRT13, KRT7, KRT8, DSP
4
Show member pathways
8.7NF1, BCL2, IL6, DSP

Compounds for genes affiliated with Spindle Cell Sarcoma

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
See all sources

Compounds related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1olopatadine46 1211.1S100B, IL6
2reticulin4610.0KRT7, S100B
3mucicarmine4610.0KRT7, S100B
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.9BCL2, S100B
5triptolide469.8BCL2, IL6
6mitoxantrone46 52 1211.8KRT8, BCL2
7b 723469.6KRT7, KRT8, S100B
8hematoxylin469.6KRT7, KRT8, S100B
9troglitazone46 30 62 1212.6IL6, BCL2, KRT13
10etoposide46 52 62 1212.6BCL2, S100B, KRT8
11paclitaxel46 52 1211.5KRT8, S100B, BCL2
12forskolin46 52 1211.5S100B, NF1, KRT8
13rituximab46 52 1211.5BCL2, IL6
14glycogen46 2510.5S100B, KRT8, KRT7
15ibuprofen46 30 52 25 1213.4IL6, BCL2
16retinoid469.4KRT7, KRT8, BCL2
17steroid469.3KRT8, NF1, S100B, DSP
18actinomycin d469.3KRT8, BCL2, IL6
19iron46 2510.3KRT7, KRT8, S100B
20genistein46 30 62 3 25 1214.2KRT8, BCL2, IL6
21testosterone46 62 25 1212.1IL6, S100B, KRT8, KRT7
22glucose469.0KRT7, KRT8, S100B, IL6
23lactate469.0KRT8, S100B, IL6
24serine468.8DSP, BCL2, S100B, NF1, KRT8
25calcium46 52 25 1211.8DSP, S100B, NF1, KRT8, KRT13
26lipid468.7IL6, S100B, NF1, KRT8, KRT7
27vegf468.7IL6, BCL2, S100B, KRT8, KRT7
28paraffin468.4BCL2, S100B, NF1, KRT8, KRT7, KRT13
29tyrosine468.4DSP, IL6, S100B, NF1, KRT8, KRT7
30progesterone46 30 62 25 1212.4DSP, BCL2, S100B, NF1, KRT8, KRT7
31estrogen468.3IL6, BCL2, S100B, NF1, KRT8, KRT7
32retinoic acid46 258.6KRT13, DSP, IL6, BCL2, S100B, NF1

GO Terms for genes affiliated with Spindle Cell Sarcoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.2KRT13, KRT7, KRT8
2intermediate filamentGO:0058828.9KRT7, KRT8, DSP
3cytoplasmGO:0057377.7BCL2, S100B, NF1, KRT8, KRT7, AFAP1L1

Biological processes related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:0093149.9BCL2, KRT13
2regulation of angiogenesisGO:0457659.9NF1, IL6
3regulation of cell-matrix adhesionGO:0019529.8NF1, BCL2
4metanephros developmentGO:0016569.7NF1, BCL2
5extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7NF1, BCL2
6axonogenesisGO:0074099.6S100B, BCL2
7cell growthGO:0160499.6BCL2, IL6
8positive regulation of peptidyl-serine phosphorylationGO:0331389.6BCL2, IL6
9negative regulation of protein kinase activityGO:0064699.5NF1, IL6
10humoral immune responseGO:0069599.5IL6, BCL2
11response to glucocorticoidGO:0513849.4S100B, BCL2, IL6
12positive regulation of apoptotic processGO:0430659.4IL6, S100B, NF1
13wound healingGO:0420609.4NF1, DSP

Molecular functions related to Spindle Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.8KRT8, DSP
2structural molecule activityGO:0051988.8KRT13, KRT7, KRT8, DSP
3protein bindingGO:0055156.4TLE2, DSP, IL6, BCL2, S100B, NF1

Products for genes affiliated with Spindle Cell Sarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spindle Cell Sarcoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet