MCID: SPN048
MIFTS: 30

Spindle Cell Thymoma malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Spindle Cell Thymoma

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Aliases & Descriptions for Spindle Cell Thymoma:

Name: Spindle Cell Thymoma 10 12
Thymoma, Medullary 10
 
Medullary Thymoma 10
Thymoma, Type a 65

Classifications:



External Ids:

Disease Ontology10 DOID:3279
SNOMED-CT59 128707003
NCIt42 C6454
UMLS65 C1266091

Summaries for Spindle Cell Thymoma

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MalaCards based summary: Spindle Cell Thymoma, also known as thymoma, medullary, is related to malignant type a thymoma and bleeding diathesis due to integrin alpha2-beta1 deficiency. An important gene associated with Spindle Cell Thymoma is CD5 (CD5 Molecule), and among its related pathways are NF-kappa B signaling pathway and Glucocorticoid receptor regulatory network. Affiliated tissues include smooth muscle and b cells.

Related Diseases for Spindle Cell Thymoma

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Diseases related to Spindle Cell Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1malignant type a thymoma33.0CD5, CD58, LCK
2bleeding diathesis due to integrin alpha2-beta1 deficiency10.6BCL2, CD5
3pilar sheath acanthoma10.5KRT5, PTGER4
4endometriosis of intestine10.5PAX8, PTGER4
5hepatorenal syndrome10.5CD5, UCHL1
6dendritic cell thymoma10.5KRT5, PAX8
7invasive malignant thymoma10.5CD5, CD58, LCK
8complement component 3 deficiency10.5PAX8, SYP
9ureter transitional cell carcinoma10.5CHGA, SYP
10thymic hyperplasia10.5CD5, CD99
11gallbladder small cell carcinoma10.5CHGA, SYP
12pediculus humanus capitis infestation10.4CHGA, SYP
13childhood malignant hemangiopericytoma10.4CHGA, SYP
14follicular infundibulum tumor10.4SYP, UCHL1
15perineural angioma10.4CHGA, SYP
16middle cerebral artery infarction10.4CHGA, SYP
17urinary system disease10.4CHGA, SYP
18peritoneal serous adenocarcinoma10.4CHGA, SYP
19signet ring basal cell carcinoma10.4CD99, KRT5
20scabies10.4CHGA, SYP
21graphite pneumoconiosis10.4CHGA, SYP
22clostridium difficile colitis10.4CHGA, PTGER4
23hypothalamic neoplasm10.4POMC, SYP
24mixed ductal-endocrine carcinoma10.4POMC, SYP
25cystadenoma10.4KRT5, PTGER4
26villous adenocarcinoma10.4CHGA, POMC
27wheat allergy10.4CHGA, SYP
28subungual glomus tumor10.4BCL2, DNTT
29pancreatic cystadenoma10.4CHGA, SYP
30pinheiro freire-maia miranda syndrome10.3CHGA, SYP
31caroli disease10.3BCL2, CHGA, SYP
32anal margin basal cell carcinoma10.3BCL2, DNTT
33corneal ectasia10.3CHGA, POMC
34partial of retinal vein occlusion10.3KRT5, PTGER4
35female breast upper-inner quadrant cancer10.3CD99, KRT5
36urethra adenocarcinoma10.3CHGA, PTGER4, SYP
37breast ductal carcinoma10.3CD99, KRT5
38cerebellar astrocytoma10.3CHGA, SYP, UCHL1
39oxyphilic adenoma10.3CHGA, KRT5, SYP
40posterior foramen magnum meningioma10.3CHGA, SYP, UCHL1
41acquired hemangioma10.3CD99, UCHL1
42thoracic benign neoplasm10.3CHGA, KRT5, SYP
43bronchiolo-alveolar adenocarcinoma10.3CD5, PTGER4
44prostate malignant phyllodes tumor10.3HLA-B, KRT5
45pancreatic solid pseudopapillary carcinoma10.3CHGA, SYP
46gastric papillary adenocarcinoma10.3CHGA, KRT5, SYP
47steroid inherited metabolic disorder10.3CHGA, PAX8, SYP
48thymus large cell carcinoma10.3CHGA, KRT5, SYP
49lung occult small cell carcinoma10.3CHGA, POMC, SYP
50bone benign neoplasm10.3CD5, CD99, SYP

Graphical network of the top 20 diseases related to Spindle Cell Thymoma:



Diseases related to spindle cell thymoma

Symptoms for Spindle Cell Thymoma

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Drugs & Therapeutics for Spindle Cell Thymoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Spindle Cell Thymoma

Genetic Tests for Spindle Cell Thymoma

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Anatomical Context for Spindle Cell Thymoma

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MalaCards organs/tissues related to Spindle Cell Thymoma:

33
Smooth muscle, B cells

Animal Models for Spindle Cell Thymoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Thymoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Spindle Cell Thymoma

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Articles related to Spindle Cell Thymoma:

(show all 11)
idTitleAuthorsYear
1
RPE65 Mutations in Two Japanese Families with Leber Congenital Amaurosis. (25495949)
2014
2
Incidence of pupillary involvement, course of anisocoria and ophthalmoplegia in diabetic oculomotor nerve palsy. (23275215)
2013
3
New insights into the medical management of idiopathic male infertility--what works, what does not and does it matter? (22704093)
2012
4
Cigarette smoking predicts differential benefit from naltrexone for alcohol dependence. (22541040)
2012
5
Inhibition of N-cadherin retards smooth muscle cell migration and intimal thickening via induction of apoptosis. (20630685)
2010
6
Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma. (17881637)
2007
7
Growth differentiation factor 9 gene and its role in reproduction.]. (15985418)
2005
8
Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases. (15883080)
2005
9
The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. (12735795)
2003
10
The dynamics of the imprinted H19 gene expression in the mouse model of bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. (9886562)
1998
11
Production of human pancreatic ribonuclease in Saccharomyces cerevisiae and Escherichia coli. (8860650)
1996

Variations for Spindle Cell Thymoma

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Expression for genes affiliated with Spindle Cell Thymoma

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Search GEO for disease gene expression data for Spindle Cell Thymoma.

Pathways for genes affiliated with Spindle Cell Thymoma

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Pathways related to Spindle Cell Thymoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7BCL2, LCK, VCAM1
29.6CHGA, KRT5, POMC
39.2BCL2, CD58, HLA-B, PTMA
48.9CD34, CD5, DNTT
58.3CD34, CD58, CD99, HLA-B, VCAM1

GO Terms for genes affiliated with Spindle Cell Thymoma

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Cellular components related to Spindle Cell Thymoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1CD34, CD5, VCAM1

Biological processes related to Spindle Cell Thymoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of intrinsic apoptotic signaling pathwayGO:200124410.4BCL2, LCK
2positive regulation of smooth muscle cell migrationGO:001491110.0BCL2, PTGER4
3negative regulation of tumor necrosis factor productionGO:00327209.2CD34, POMC, PTGER4
4single organismal cell-cell adhesionGO:00163378.9BCL2, CD34, CD58, VCAM1

Sources for Spindle Cell Thymoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet