Spinocerebellar Ataxia malady

Disease Ontology: A spinocerebellar degeneration that has material basis in expanded cag triplet repeats resulting in spinal cord and cerebellum degeneration.⁶

MalaCards: Spinocerebellar Ataxia, also known as spinocerebellar ataxias, is related to spinocerebellar ataxia type 6 and spinocerebellar ataxia type 3. An important gene associated with Spinocerebellar Ataxia is ATXN1 (ataxin 1), and among its related pathways are Proteolysis_Putative ubiquitin pathway and Regulation of degradation of deltaF508 CFTR in CF. The compounds n acetylcysteine and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and spinal cord, and related mouse phenotypes are muscle and cellular.

Wikipedia: Spinocerebellar ataxia (SCA) is a progressive, degenerative,genetic disease with multiple types, each of...⁴⁴ more...

Aliases & Descriptions:

spinocerebellar ataxia 6 7 44 30 8 spinocerebellar ataxias 17 32

spinocerebellar ataxia (disorder) 6 ataxia, spinocerebellar 43

Disease types for spinocerebellar ataxia family:

spinocerebellar ataxia type 3	spinocerebellar ataxia type 6
spinocerebellar ataxia type 7	spinocerebellar ataxia type 8
spinocerebellar ataxia type 10	spinocerebellar ataxia type 11
spinocerebellar ataxia type 12	spinocerebellar ataxia type 13
spinocerebellar ataxia type 14	spinocerebellar ataxia type 15
spinocerebellar ataxia type 17	spinocerebellar ataxia type 20
spinocerebellar ataxia type 28	spinocerebellar ataxia 18
spinocerebellar ataxia 19	spinocerebellar ataxia 21
spinocerebellar ataxia 23	spinocerebellar ataxia 25
spinocerebellar ataxia 26	spinocerebellar ataxia 27
spinocerebellar ataxia 29	spinocerebellar ataxia 30
spinocerebellar ataxia 31	spinocerebellar ataxia 34
spinocerebellar ataxia 4	spinocerebellar ataxia 5
spinocerebellar ataxia 9

Diseases related to spinocerebellar ataxia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 260)

id	Related Disease	Score	Top Affiliating Genes
1	spinocerebellar ataxia type 6	38.0	BLZF1, KCNA1, HSF1, HSPA1A, CACNA1A
2	spinocerebellar ataxia type 3	37.2	USP15, CHERP, UBC, ATXN3, ATXN1, FOXO4
3	spinocerebellar ataxia type 7	37.1	CHERP, ATXN3, ATXN2, ATXN1, ATN1, ATXN7
4	infantile onset spinocerebellar ataxia	36.5	CHERP, ATXN8, ATXN8OS, TTPA
5	olivopontocerebellar atrophy	36.3	ATXN2, GLUD1, SNCA
6	spinocerebellar ataxia type 14	36.1	SGCE, PRKCG, PRKACG
7	spinocerebellar ataxia type 17	36.0	KHSRP, PARK7, HSPA5, HSPA8, TBP, TAF1
8	spinocerebellar ataxia type 12	35.3	ATXN3, ATXN2, ATXN8OS, ATXN1, ATN1, ATXN7
9	cerebellar ataxia	34.3	ZNF592, SETX, CLA3, BEAN1, KCNA1, KCNC3
10	x-linked sideroblastic anemia with ataxia	32.4	FXN, ALAS2, ABCB7
11	axonal neuropathy	32.3	SETX, LIG3, SACS, ATCAY, APTX, HSPB1
12	parkinson's disease	32.3	PARK7, MAPT, TBP, SNCA
13	friedreich ataxia	32.2	SETX, SACS, ATXN3, ATXN2, ATXN8OS, ATCAY
14	spinocerebellar degeneration	31.9	CHERP, ATXN3, ATXN2, ATXN1, ANP32A, CACNA1A
15	nystagmus	31.8	KCNA1, SACS, ATCAY, FXN, ANO10, CACNA1A
16	dentatorubral-pallidoluysian atrophy	31.4	ATXN2, ATN1, HTT, CACNA1A, RPS27A, PVALB
17	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	31.3	APTX, HTT, SLC6A3
18	neuropathy	31.3	SETX, LIG3, KCNA1, SCA18, SCA25, SCAR3
19	huntington's disease	31.0	SERPINA3, CHERP, ATXN3, ATXN1, ATN1, ATXN7
20	ophthalmoplegia	30.6	ATXN3, ATXN2, ATXN1, ATXN7, PLEKHG4, C10orf2
21	huntington disease-like	30.2	ATN1, HTT, TBP, PRNP
22	restless legs syndrome	30.1	ATXN3, ATXN2, ATXN1, ATXN7, CACNA1A, DRD2
23	peripheral neuropathy	30.0	SETX, SCAR3, MT-ND1, SACS, ATXN3, ATXN2
24	myotonic dystrophy type 1	29.9	KCNN3, ATXN1, AR, MAPT, HSPA5
25	sideroblastic anemia	29.8	FXN, ALAS2, ABCB7, SOD2
26	neurodegeneration	29.7	SERPINA3, BLZF1, KHSRP, PARK7, CHERP, YWHAE
27	tremor	29.6	SGCE, SETX, PARK7, ATXN2, ATCAY, FRAXA
28	optic atrophy	29.6	ZNF592, SCAR3, MT-ND1, ATXN3, ATXN2, ATXN1
29	myotonic dystrophy	29.3	KCNN3, ATXN10, ATXN3, ATXN1, FMR1, AR
30	multiple system atrophy	29.0	SERPINA3, PARK7, ATXN3, ATXN2, ATXN8OS, ATXN1
31	muscular atrophy	28.9	BLZF1, KHSRP, SCA18, CHERP, SACS, ATXN3
32	hypogonadism	28.7	LEPR, ATXN2, FXN, AR, CALCA, SHBG
33	myoclonus	28.5	SGCE, SCASI, UBC, MT-TK, MT-CO2, ATXN2
34	dementia	28.4	SERPINA3, PARK7, SCAX4, MT-ATP6, MT-ND1, S100G
35	ataxia	27.8	ZNF592, KLHL1, SGCE, CNTN4, RBFOX1, SETX
36	anemia	27.0	RBM17, BLZF1, CHERP, UBC, MT-ATP6, ATXN10
37	retinitis	26.5	USH2A, BLZF1, CHERP, YWHAE, UBC, MT-ATP6
38	schizophrenia	25.7	SGCE, CNTN4, SERPINA3, RAI1, PARK7, KCNN3
39	obesity	25.6	RBFOX1, RAI1, LEPR, MT-ATP6, MT-ND1, ATXN3
40	multiple sclerosis	24.2	LIG3, PARK7, LEPR, YWHAE, MT-TK, MT-TL1
41	alzheimer's disease	23.3	CNTN4, RBM17, SERPINA3, BLZF1, KHSRP, PARK7
42	neuronitis	23.1	KLHL1, CNTN4, RBFOX1, SETX, SERPINA3, RAI1
43	hereditary ataxia	14.3	ATXN3, ATXN2, ATXN1, ATN1, ATXN7, FXN
44	cerebellar degeneration	14.1	BLZF1, ATXN2, CACNA1A, GLUD1, SPG7, PRNP
45	neuronal intranuclear inclusion disease	14.0	ATXN3, ATXN1, MAPT, SNCA, RPS27A, ABT1
46	apraxia	14.0	SETX, FXN, APTX, MAPT, TTPA
47	ataxia with isolated vitamin e deficiency	13.9	SETX, FXN, APTX, TTPA
48	transient cerebral ischemia	13.9	ITPR1, MAPT, HSPA5, HSPA1A, HSPA4, RPS27A
49	spinal-bulbar muscular atrophy	13.9	CHERP, SACS, ATXN3, ATXN1, AR, HTT
50	memory impairment	13.9	FMR1, MAPT, SNCA, PDYN, PRNP, SLC6A3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spinocerebellar ataxia:

²²

MGI Mouse Phenotypes related to spinocerebellar ataxia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	8.5	TK2, TTPA, AGTPBP1, PDLIM3, CRAT, DNM1L
2	cellular phenotype	MP:0005384	7.7	TK2, ABCB7, PDYN, CRAT, SNCA, DAGLA
3	reproductive system phenotype	MP:0005389	7.6	DRD2, AKT1, CACNA1A, HSPA4, HSPA1A, HSPA5
4	nervous system phenotype	MP:0003631	7.2	DNM1L, DLST, DRD2, AKT1, GLUL, CACNA1A
5	growth/size phenotype	MP:0005378	6.8	GAPDH, AFG3L2, AFF2, NEDD4, SLC6A3, PDYN
6	homeostasis/metabolism phenotype	MP:0005376	6.5	ABCB7, PDYN, PDLIM3, CRAT, SNCA, DAGLA
7	mortality/aging	MP:0010768	6.1	DLD, SUMF1, SNCA, PDLIM3, ABCB7, TBP
8	behavior/neurological phenotype	MP:0005386	6.1	ATXN7, PARK7, LIG3, RAI1, RBFOX1, SGCE

Articles related to spinocerebellar ataxia:

(show top 50)    (show all 355)

id	Title	Authors	Year	Affiliating Genes
1	Spinocerebellar ataxia type 6. (21827907)	Solodkin A.... Gomez C.M.	2012	CACNA1A
2	Spinocerebellar ataxia type 15: diagnostic assessment , frequency, and phenotypic features. (21367767)	Synofzik M.... Bauer P.	2011	ITPR1
3	The occurrence of spinocerebellar ataxias caused by d ynamic mutations in Polish patients. (20625959)	SuA8ek-Piatkowska A.... Zaremba J.	2010	ATXN3
4	Myoclonus-dystonia and spinocerebellar ataxia type 14 presenting with similar phenotypes: trunk tremor, myoclonus, and dystonia. (19913450)	Foncke E.M.... Tijssen M.A.	2010	SGCE
5	High frequency of Machado-Joseph disease identified i n southeastern Chinese kindreds with spinocerebellar ataxia. (20334689)	Gan S.R.... Wu Z.Y.	2010	ATXN3
6	Spinocerebellar ataxia type 31 is associated with 'inserted' penta- nucleotide repeats containing (TGGAA)n. (19878914)	Sato N.... Mizusawa H.	2009	NEDD4, TK2, BEAN1
7	The p62 antibody reveals various cytoplasmic protein aggregates in spinocerebellar ataxia type 6. (19788049)	Seidel K.... den Dunnen W.F.	2009	CACNA1A, BLZF1
8	Mitochondrial tRNALeu/Lys and ATPase 6/8 gene variations in spinocerebellar ataxias. (19066432)	Safaei S.... Shariati P.	2009	MT-CO2, MT-ND1, MT-ATP6
9	Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis. (18499672)	Adachi N.... Saito N.	2008	PRKCG
10	Spinocerebellar ataxia type 2 (SCA2) in an Egyptian family presenting with polyphagia and marked CAG expansion in infancy. (18297329)	Abdel-Aleem A.... Zaki M.S.	2008	ATXN2
11	Spinocerebellar ataxia 2 (SCA2). (18418684)	Lastres-Becker I.... Auburger G.	2008	ATXN2, CHERP
12	Periodic alternating nystagmus and periodic alternating skew deviation in spinocerebellar ataxia type 6. (19145126)	Colen C.B.... Van Stavern G.P.	2008	CACNA1A
13	The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias. (18047739)	Davies J.E.... Rubinsztein D.C.	2007	RPS27A
14	The clinical features and gene mutation analysis in a pedigree of spinocerebellar ataxia type 7 (17650485)	Yin X.Z.... Zhang H.	2007	CACNA1A, ATXN3, ATXN1
15	The P/Q-type voltage-dependent calcium channel: a therapeutic target in spinocerebellar ataxia type 6. (17489948)	Gazulla J.... TintorAc M.	2007	CACNA1A
16	Case of spinocerebellar ataxia type 17 (SCA17) associated with only 41 repeats of the TATA-binding protein (TBP) gene. (17149738)	Nanda A.... Metzer W.S.	2007	TBP
17	Molecular pathogenesis of spinocerebellar ataxia type 6. (17395139)	Kordasiewicz H.B.... Gomez C.M.	2007	CACNA1A
18	Spinocerebellar ataxia type 20 is genetically distinct from spinocerebellar ataxia type 5. (17159129)	Lorenzo D.N.... Knight M.A.	2006	SCA20
19	Spinocerebellar ataxia type 3 (SCA3): thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions. (16911479)	Rub U.... Deller T.	2006	ATXN3
20	Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4. (16763984)	Hiramoto K.... Sakai N.	2006	PRKCG
21	CAG repeats containing CAA interruptions form branched hairpin structures in spinocerebellar ataxia type 2 transcripts. (15533937)	Sobczak K.... Krzyzosiak W.J.	2005	ATXN2
22	Spinocerebellar ataxia type 17 in the Yugoslav population. (14763955)	Alendar A.... Romac S.	2004	TBP
23	Large de novo expansion of CAG repeats in patient with sporadic spinocerebellar ataxia type 7. (15316811)	Bauer P.... Goetz P.	2004	ATXN7
24	Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families. (15148151)	Brusco A.... Taroni F.	2004	PRKCG, TBP, ITPR1
25	Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3. (14679302)	Griffin J.L.... Pook M.A.	2004	ATXN3
26	Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophy. (14571264)	Michalik A.... Van Broeckhoven C.	2004	ATXN7
27	Spinocerebellar ataxia 7 (SCA7). (14526176)	Lebre A.S.... Brice A.	2003	ATXN7
28	A novel autosomal dominant spinocerebellar ataxia (SCA22) linked to chromosome 1p21-q23. (12764052)	Chung M.Y.... Soong B.W.	2003	SCA22
29	A new dominant spinocerebellar ataxia linked to chromosome 19q13.4-qter. (12164726)	Brkanac Z.... Bird T.D.	2002	PRKCG
30	Pontine atrophy in spinocerebellar ataxia type 6. (10601803)	Sugawara M.... Masamune O.	2000	CACNA1A
31	Evidence for a common Spinocerebellar ataxia type 7 (SCA7) founder mutation in Scandinavia. (11175279)	Jonasson J.... Holmberg M.	2000	ATXN7
32	Spinocerebellar ataxia 2 (SCA2): morphometric analyses in 11 autopsies. (10090679)	Estrada R.... Auburger G.	1999	ATXN2
33	Nuclear inclusions in spinocerebellar ataxia type 1. (9928833)	Duyckaerts C.... Brice A.	1999	ATXN1
34	An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8) (10192387)	Koob M.D.... Ranum L.P.	1999	ATXN8OS
35	Initial symptoms and mode of neurological progression in spinocerebellar ataxia type 6 (SCA6) (9847664)	Yabe I.... Tashiro K.	1998	CACNA1A
36	Spinocerebellar ataxia type 6: MRI of three Japanese patients. (9592791)	Satoh J.I.... Kuroda Y.	1998	CACNA1A
37	Trinucleotide repeat expansion of spinocerebellar ataxia (SCA1) found in a Chinese family. (10374379)	Cai T.... Lopa M.	1998	ATXN1
38	Spinocerebellar ataxia type 6: gaze-evoked and vertical nystagmus, Purkinje cell degeneration, and variable age of onset. (9403487)	Gomez C.M.... Anderson J.H.	1997	CACNA1A
39	Analysis of spinocerebellar ataxia types 1, 2, 3, and 6, dentatorubral-pallidoluysian atrophy, and Friedreich's ataxia genes in spinocerebellar ataxia patients in the UK. (9429138)	Leggo J.... Rubinsztein D.C.	1997	CACNA1A, ATXN2
40	An apparently sporadic case with spinocerebellar ataxia type 1 (SCA1) (9404150)	Futamura N.... Takayanagi T.	1997	ATXN1
41	Peptidergic sweating in multiple system atrophy and hereditary spinocerebellar ataxia with special reference to calcitonin gene-rel ated peptide (8741344)	Kumazawa K.... Mitsuma T.	1996	CALCA
42	Unstable triplet repeat and phenotypic variability of spinocerebellar ataxia type 1. (8619528)	Goldfarb L.G.... Gajdusek D.C.	1996	ATXN1
43	A novel CAG repeat configuration in the SCA1 gene: implications for the molecular diagnostics of spinocerebellar ataxia type 1. (8634720)	Quan F.... Popovich B.W.	1995	ATXN1
44	Trinucleotide expansion within the MJD1 gene presents clinically as spinocerebellar ataxia and occurs most frequently in German SCA patients. (7655453)	Schols L.... Riess O.	1995	ATXN3
45	Molecular and clinical correlations in spinocerebellar ataxia type I: evidence for familial effects on the age at onset. (8037204)	Ranum L.P.... Goldfarb L.	1994	ATXN1
46	Autosomal dominant spinocerebellar ataxia (SCA) in a Siberian founder population: assignment to the SCA1 locus. (7925830)	Lunkes A.... Auburger G.	1994	ATXN1
47	Spinocerebellar Ataxia Type 14 (20301573)	Chen D.H.... Raskind W.H.	1993	PRKCG
48	Spinocerebellar Ataxia Type 8 (20301445)	Ikeda Y.... Ranum L.P.W.	1993	ATXN8OS, ATXN8
49	Infantile-Onset Spinocerebellar Ataxia (20301746)	Nikali K.... LAPnnqvist T.	1993	C10orf2
50	Spinocerebellar Ataxia Type 6 (20301319)	Gomez C.M.	1993	CACNA1A

Genes related to spinocerebellar ataxia according to GeneCards:

(show top 50)    (show all 168)

id	Symbol	Description	Score	GeneCards Section Context
1	ATXN1	ataxin 1	11.1	Summaries, Aliases & Descriptions, Orthologs, Publications
2	ATXN7	ataxin 7	11.1	Summaries, Aliases & Descriptions, Publications
3	ATXN2	ataxin 2	11.1	Aliases & Descriptions, Orthologs, Summaries, Publications
4	ATXN3	ataxin 3	11.1	Aliases & Descriptions, Publications, Orthologs, Summaries
5	ATXN10	ataxin 10	11.1	Orthologs, Publications, Summaries, Aliases & Descriptions
6	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	11.1	Aliases & Descriptions, Summaries, Publications
7	SPTBN2	spectrin, beta, non-erythrocytic 2	11.1	Summaries, Publications, Aliases & Descriptions
8	PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	11.1	Aliases & Descriptions, Summaries, Publications
9	ATXN8OS	ATXN8 opposite strand (non-protein coding)	11.1	Publications, Summaries, Aliases & Descriptions
10	TTBK2	tau tubulin kinase 2	11.1	Summaries, Aliases & Descriptions, Publications
11	ZNF592	zinc finger protein 592	11.1	Summaries, Aliases & Descriptions
12	C10orf2	chromosome 10 open reading frame 2	11.1	Publications, Aliases & Descriptions, Summaries
13	PLEKHG4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	11.1	Summaries, Aliases & Descriptions, Publications, UniProt Related
14	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	11.1	Publications, Summaries
15	PRKCG	protein kinase C, gamma	11.1	Publications, Summaries
16	TBP	TATA box binding protein	11.1	Summaries, Publications, Orthologs
17	TDP1	tyrosyl-DNA phosphodiesterase 1	11.1	Summaries, Publications
18	SCASI	spinocerebellar ataxia with saccadic intrusions	11.1	Aliases & Descriptions
19	ATXN8	ataxin 8	11.1	Summaries, Publications
20	SYNE1	spectrin repeat containing, nuclear envelope 1	11.1	Summaries
21	KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	11.1	Aliases & Descriptions, Publications
22	BEAN1	brain expressed, associated with NEDD4, 1	11.1	Summaries, Publications
23	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	11.1	Summaries
24	SCAX5	Spinocerebellar ataxia, X-linked 5	11.1	Aliases & Descriptions
25	SCAR7	spinocerebellar ataxia, autosomal recessive 7	11.1	Publications, Aliases & Descriptions
26	SCAR6	spinocerebellar ataxia, autosomal recessive 6	11.1	Aliases & Descriptions
27	SCAR3	spinocerebellar ataxia, autosomal recessive 3	11.1	Publications, Aliases & Descriptions
28	SCA20	spinocerebellar ataxia 20	11.1	Publications, Aliases & Descriptions
29	SCAX1	spinocerebellar ataxia, X-linked 1	11.1	Aliases & Descriptions
30	SCAR2	spinocerebellar ataxia, autosomal recessive 2	11.1	Aliases & Descriptions
31	AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	11.1	Publications, Aliases & Descriptions
32	ATXN2L	ataxin 2-like	11.1	Summaries, Publications
33	TGM6	transglutaminase 6	11.1	Summaries
34	SYT14	synaptotagmin XIV	11.1	Summaries, Publications
35	C20orf194	chromosome 20 open reading frame 194	11.1	Summaries, Publications
36	ANO10	anoctamin 10	11.1	Summaries
37	SCA34	spinocerebellar ataxia 34	11.1	Aliases & Descriptions
38	SCA9	spinocerebellar ataxia 9	11.1	Publications, Aliases & Descriptions
39	SCA26	spinocerebellar ataxia 26	11.1	Aliases & Descriptions, Publications
40	SCA25	spinocerebellar ataxia 25	11.1	Publications, Aliases & Descriptions
41	SCA30	spinocerebellar ataxia 30	11.1	Aliases & Descriptions
42	SCA29	spinocerebellar ataxia 29	11.1	Aliases & Descriptions
43	SCA21	spinocerebellar ataxia 21	11.1	Aliases & Descriptions, Publications
44	SCA18	spinocerebellar ataxia 18 (sensory with neurogenic muscular atrophy)	11.1	Aliases & Descriptions, Publications
45	SCA31	spinocerebellar ataxia 31	11.1	Aliases & Descriptions, Publications
46	SCA19	spinocerebellar ataxia 19	11.1	Publications, Aliases & Descriptions
47	PDYN	prodynorphin	11.1	Aliases & Descriptions, Publications
48	SCAR12	Spinocerebellar ataxia, autosomal recessive 12	11.1	Aliases & Descriptions
49	SCA37	spinocerebellar ataxia 37	11.1	Aliases & Descriptions
50	SCA32	spinocerebellar ataxia 32	11.1	Aliases & Descriptions

Pathways related to spinocerebellar ataxia according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	Proteolysis_Putative ubiquitin pathway41	10.7	HSPA8, HSPA4, HSPA1A, HSPA5, ATXN3, UBC
2	Regulation of degradation of deltaF508 CFTR in CF41	10.7	HSPA8, HSPA4, HSPA1A, HSPB1, HSPA5, ATXN3
3	Proteolysis Putative ubiquitin pathway10	10.6	HSPA8, HSPA4, HSPA1A, HSPA5, ATXN3
4	Androgen Signaling36	10.6	PRKACG, PRKCG, SHBG, TBP, CACNA1A, HSPA4
5	Parkinsons Disease Pathway36	10.6	SLC6A3, PSMC1, SNCA, HSPA4, UBC, PARK7
6	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway10	10.4	PSMC1, SNCA, HSPA8, HSPA4, HSPA1A, HSPA5
7	Neuroscience3	10.3	PARK7, NEFL, TARDBP, AGTPBP1, SNCA, DLST
8	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway41	10.3	PSMC1, SNCA, HSPA8, HSPA4, HSPA1A, HSPA5
9	Glutamatergic synapse20	10.2	SLC1A6, PRKACG, PRKCG, GLUL, GLS, CACNA1A
10	Huntingtons disease20	9.4	SOD2, COX6C, TBPL2, TBP, HTT, ITPR1
11	CREB Pathway36	9.2	PRKACG, PRKCG, PPBP, TBP, AKT1, CACNA1A
12	Alzheimers disease20	9.1	COX6C, SNCA, MAPT, ITPR1, MT-ATP8, MT-ATP6
13	Parkinsons disease20	8.3	SLC6A3, COX6C, SNCA, MT-ATP8, MT-ND1, MT-ATP6

Compounds related to spinocerebellar ataxia according to GeneDecks:

(show top 50)    (show all 119)

id	Compound	Score	Top Affiliating Genes
1	n acetylcysteine32	10.6	SNCA, HSF1, RPS27A, CRAT, MAPT, AR
2	alpha tocopherol32	10.5	HSPA8, TBP, SNCA, HSPA4, HSPA1A, FXN
3	mg 13232 42	11.4	HSF1, MAPT, AR, HSPA1A, RPS27A, SNCA
4	methamphetamine32 9 9	12.1	PDYN, RPS27A, GAPDH, SLC6A3, SOD2, DRD2
5	lysine32	10.1	PARK7, F13A1, CACNA1A, SPG7, PRKACG, PRNP
6	potassium32 9 18 9	13.1	ABCB7, KCNA1, HSPA1A, HSPA4, BLZF1, AFP
7	silver32	10.0	AFP, RPS27A, SNCA, PVALB, GLO1, HSPA8
8	6-hydroxydopamine32	10.0	SLC6A3, GAPDH, DRD2, PARK7, SNCA, RPS27A
9	glycerol32 9 18 9	13.0	GLUD1, HSPA4, HSPA8, GLUL, TBP, RPS27A
10	sodium dodecylsulfate32	9.9	MAPT, AR, GLUD1, TBP, RPS27A, TTR
11	citrate32	9.9	MT-CO2, SOD2, OGDH, CRAT, PPBP, GLUD1
12	butyrate32	9.9	HTT, ALAS2, MAPT, FMR1, HSF1, HSPB1
13	glyceraldehyde 3-phosphate32	9.8	TBP, GAPDH, GLUD1, GLS, GLO1, HSPA8
14	cysteine32	9.8	HTT, ATN1, HSPA5, HSPA8, GLO1, GLS
15	rotenone32	9.7	MT-ND1, HSPA4, HSPA8, SNCA, RPS27A, DNM1L
16	urea32 9 18 9	12.7	AFP, TTR, SERPINA3, MAPT, F13A1, HSPA1A
17	glycogen32 18	10.6	HSPA5, HTT, MAPT, FOXO4, LEPR, HSF1
18	superoxide32 18	10.6	HTT, LEPR, PARK7, BLZF1, SERPINA3, PRNP
19	polyacrylamide32	9.6	GAPDH, BLZF1, HSPB1, NEFL, SOD2, PRNP
20	leucine32	9.5	TBP, SERPINA3, HSF1, HSPA5, HSPB1, ANP32A
21	zinc32 18	10.5	GLO1, HSPA8, HSPA1A, HSPA5, HSF1, ALAS2
22	hydrogen32 18	10.4	MT-CO2, GLS, RPS27A, GLUD1, MT-ATP6, GLO1
23	gaba32 42	10.4	PDYN, DRD2, CRAT, RPS27A, PVALB, FMR1
24	acetylcholine32 9 18 9	12.4	BLZF1, SNCA, SOD2, MAPT, SERPINA3, DRD2
25	methionine32	9.3	PVALB, PRNP, MAPT, MT-ND1, PARK7, SERPINA3
26	nmda32 42	10.3	HSPA4, AKT1, DRD2, RPS27A, GAPDH, PDYN
27	actinomycin d32	9.2	RPS27A, CRAT, AKT1, GLUL, GLS, HSPA4
28	testosterone32 9 18 9	12.1	RPS27A, LEPR, HSPA8, CALCA, AKT1, CRAT
29	paraffin32	9.1	RPS27A, AFP, AR, MAPT, F13A1, HSPB1
30	creatinine32	9.1	SHBG, ABCB7, TTR, OGDH, SOD2, NEFL
31	threonine32	9.1	CACNA1A, GLUD1, TTR, PRKCG, PRKACG, AFP
32	epinephrine32 9 18 9	12.0	AR, SOD2, GAPDH, CALCA, PDYN, TTR
33	proline32	9.0	HSPA5, GLUD1, GLUL, TBP, HSPA8, HSF1
34	adenylate32	9.0	POLG, GAPDH, GLO1, HSPA4, CALCA, BLZF1
35	arginine32	8.9	GLUL, PRKACG, SERPINA3, BLZF1, SOD2, PRNP
36	h2o232	8.8	HSPA8, HSPA4, HSPA1A, HSPB1, HSPA5, HSF1
37	aspartate32	8.7	AR, MAPT, KHSRP, TTR, TOP1, PVALB
38	iron32 18	9.6	PVALB, PRNP, SOD2, AFP, GLO1, TTR
39	pyruvate32	8.6	HSPA5, GLS, BLZF1, MT-ND3, MT-ND1, GLUD1
40	calcium32 9 18 9	11.6	AFP, SUMF1, GLUL, GLS, CACNA1A, HSPA8
41	valine32	8.5	TTR, HSPA5, RPS27A, DLD, SERPINA3, AR
42	dopamine32 9 18 9	11.5	HSPA5, HSPA4, HSPA8, CALCA, HTT, MAPT
43	alanine32	8.5	BLZF1, TTR, POLG, NEDD4, AFP, ABT1
44	oxygen32 18	9.4	HSF1, HSPA5, HSPB1, HSPA1A, HSPA4, HSPA8
45	glutamine32	8.3	ATN1, ATXN7, AR, GRIK2, ANP32A, MAPT
46	atp32	8.2	PPBP, ITPR1, FXN, MT-ND1, MT-ATP6, MT-CO2
47	glucose32	8.0	PDYN, SNCA, GLUD1, ABCB7, GLUL, AKT1
48	glutamate32	7.9	BLZF1, LEPR, S100G, ITPR1, FMR1, AR
49	lactate32	7.8	MAPT, MT-ND1, MT-CO2, BLZF1, GAPDH, AFP
50	serine32	7.4	PPBP, SNCA, TBP, DLD, AKT1, GLUL

Cellular components related to spinocerebellar ataxia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial matrix	GO:005759	9.9	OGDH, TK2, DLST, DLD, GLUD1, GLS
2	axon	GO:030424	9.4	CNTN4, NEFL, SLC6A3, PVALB, SNCA, DRD2
3	dendrite	GO:030425	9.4	PRKCG, DRD2, CACNA1A, HTT, AR, ATXN1L
4	mitochondrion	GO:005739	8.9	ABCB7, CRAT, SNCA, PPP2R2B, AGTPBP1, OGDH
5	cytoplasm	GO:005737	7.3	TBP, TBPL2, DLST, SNCA, AKT1, GLUL

Biological processes related to spinocerebellar ataxia according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell death	GO:008219	11.0	AFG3L2, DAGLA, SPTBN2, SPG7, NOP56, PDYN
2	fibroblast growth factor receptor signaling pathway	GO:008543	10.3	PRKACG, PRKCG, RPS27A, AKT1, FGF14, FOXO4
3	negative regulation of neuron apoptotic process	GO:043524	10.0	SOD2, PRKCG, SNCA, CACNA1A, HTT, GRIK2
4	anti-apoptosis	GO:006916	10.0	PRNP, RPS27A, SNCA, AKT1, GLO1, HSPB1
5	adult walking behavior	GO:007628	9.8	AGTPBP1, DRD2, CACNA1A, MAPT, FXN, KLHL1
6	synaptic transmission	GO:007268	9.8	PDYN, ACTN2, PRKCG, SLC6A3, SLC1A6, NEFL
7	platelet activation	GO:030168	9.8	ACTN2, PPBP, DAGLA, AKT1, HSPA5, F13A1
8	RNA metabolic process	GO:016070	9.8	PSMC1, RPS27A, AKT1, HSPA8, HSPB1, ANP32A

Molecular functions related to spinocerebellar ataxia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	6.2	GAPDH, ACTN2, ABT1, NOP56, SNCA, PPP2R2B