ES
MCID: SPR013
MIFTS: 40

Spiradenoma (ES) malady

Skin diseases category

Summaries for Spiradenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

MalaCards: Spiradenoma, also known as eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)). The compounds hpvs and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and smooth muscle, and related mouse phenotype cellular.

Aliases & Classifications for Spiradenoma

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Sources:
8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

spiradenoma 8 10
eccrine spiradenoma 8 42 60
benign eccrine spiradenoma 8 42
eccrine spiradenoma, benign 42
eccrine spiradenoma of skin 8
es 42


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Disease Ontology8 DOID:5444
SNOMED-CT56 4977000, 403938001
NCIt39 C4170

Related Diseases for Spiradenoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1brooke-spiegler syndrome30.6CYLD
2sarcoma30.4TP53, S100A1, ACTC1
3syringoma30.1S100A1, KRT14
4adenoid cystic carcinoma30.1S100A1, ACTC1, KRT7, KRT14, CYLD
5papillary carcinoma30.0KRT7, ACTC1, S100A1, KRT14
6hidradenoma29.9CLEC2A
7thymoma29.9DNTT
8glomus tumor29.9ACTC1, S100A1
9adenoma29.8KRT14, ACTC1, S100A1, KRT7, TP53
10endometrial carcinoma29.7KRT7, TP53
11breast cancer29.7KRT7, KRT14, TP53, ACTC1, S100A1, KRT15
12malignant spiradenoma10.8
13primitive neuroectodermal tumor10.2
14breast malignant eccrine spiradenoma10.2
15benign eccrine breast spiradenoma10.2
16adenoiditis10.2
17adnexal spiradenoma/cylindroma of a sweat gland10.2
18status epilepticus10.2
19neuronitis10.2
20thyroiditis10.2
21urinary schistosomiasis10.1
22schistosomiasis10.1
23sweat gland carcinoma10.1
24tetanus neonatorum10.0
25penis sarcoma10.0
26acute leukemia10.0
27cell type cancer10.0
28epithelioid sarcoma10.0
29extrapulmonary tuberculosis10.0
30filariasis10.0
31leukemia10.0
32malaria10.0
33pancreatitis10.0
34papillary thyroid carcinoma10.0
35tetanus10.0
36thyroid cancer10.0
37tuberculosis10.0
38keratosis10.0CLEC2A
39pilomatrixoma10.0CLEC2A
40paraganglioma10.0S100A1
41craniopharyngioma10.0KRT14
42epidermolysis bullosa10.0KRT14
43hidrocystoma10.0SGTA
44meningioma10.0S100A1
45cystadenoma10.0KRT7
46mixed cell type cancer10.0KRT7
47thymus cancer10.0KRT7
48nephroblastoma10.0TP53
49syringocystadenoma papilliferum10.0KRT15, CLEC2A
50epidermolysis bullosa simplex10.0KRT14

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to spiradenoma

Clinical Features for Spiradenoma

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Drugs & Therapeutics for Spiradenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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32MalaCards
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MalaCards organs/tissues related to Spiradenoma:

32
Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spiradenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.5TP53, ACTC1, KRT7, KRT14, CYLD, DNTT

Publications for Spiradenoma

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Sources:
50PubMed
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Articles related to Spiradenoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. (24118397)
2013
2
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma and eccrine spiradenoma. (24261740)
2013
3
Neonatal spiradenoma. (22747799)
2013
4
Malignant eccrine spiradenoma: a meta-analysis of reported cases. (20851376)
2011
5
Giant vascular eccrine spiradenoma. (22148049)
2011
6
A rare case of giant malignant eccrine spiradenoma. (21342314)
2011
7
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression. (21598248)
2011
8
Carcinosarcoma ex eccrine spiradenoma of the vulva: report of the first case. (21464722)
2011
9
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
10
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. (20101314)
2009
11
Multiple nodules of the head--clinicopathologic challenge. Multiple eccrine spiradenoma. (19261009)
2009
12
Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)
2009
13
Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. (19194280)
2009
14
Direct intracranial extension of malignant eccrine spiradenoma of the face. (22493654)
2009
15
Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. (19633533)
2009
16
Recurrent atypical eccrine spiradenoma of the forehead. (19181014)
2008
17
A case of eccrine spiradenoma arising in nevus sebaceous in an adolescent girl. (18360132)
2008
18
Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)
2007
19
Malignant eccrine spiradenoma. (17474253)
2007
20
Two cases of multiple eccrine spiradenoma with linear or localized formation. (15492423)
2004
21
Linear spiradenoma with focal malignant transformation. (12702073)
2003
22
Malignant eccrine spiradenoma: an unusual presentation. (17656974)
2002
23
Eccrine spiradenoma. (17656951)
2002
24
Malignant eccrine spiradenoma of the neck: a case report. (11593191)
2001
25
Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. (10075300)
1999
26
Spiradenocylindromas of the skin: tumors with morphological features of spiradenoma and cylindroma in the same lesion: report of 12 cases. (10417685)
1999
27
Malignant eccrine spiradenoma with florid squamous differentiation. (9610621)
1998
28
Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements. (9462275)
1997
29
Malignant eccrine spiradenoma. Case report and review of the literature. (9391538)
1997
30
Eccrine spiradenoma, not poroma. (8634818)
1996
31
An unusual, recurring breast tumor with features of eccrine spiradenoma: a case report. (8929479)
1996
32
Over-expression of p53 protein as an indicator of the malignant transformation in spiradenoma. (7657312)
1995
33
Stump the experts. Eccrine spiradenoma. (8388416)
1993
34
Malignant eccrine spiradenoma. A clinicopathologic study. (1384379)
1992
35
Cytogenetics of a case of eccrine spiradenoma. (1325410)
1992
36
Congenital spiradenoma. (2851273)
1988
37
Multiple eccrine spiradenoma: case report and review. (2846662)
1988
38
Eccrine spiradenoma: report of a case. (2845039)
1988
39
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
40
Malignant transformation of eccrine spiradenoma. (2996443)
1985
41
Eccrine spiradenoma (a case report). (6100593)
1984
42
Eccrine spiradenoma: clinical and pathologic study of 49 tumors. (6313776)
1983
43
Pathology quiz case 2. Eccrine spiradenoma. (6284064)
1982
44
Cylindroma and eccrine spiradenoma coexistent in the same lesion. (6279036)
1982
45
Malignant transformation of eccrine spiradenoma. (4341946)
1972
46
Eccrine spiradenoma. (4103044)
1971
47
Eccrine spiradenoma. Histochemical and electron microscopic studies. (4286974)
1966
48
A light- and electron-microscopic study of a case of multiple eccrine spiradenoma. (14477202)
1962
49
An unusual tumor of the breast resembling eccrine spiradenoma. (13661107)
1959
50
Eccrine spiradenoma; report of a case and preliminary pharmacologic studies. (13423892)
1957

Genetic Variations for Spiradenoma

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Expression for genes affiliated with Spiradenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

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Compounds for genes affiliated with Spiradenoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1hpvs449.9KRT14, TP53
2actomyosin449.7ACTC1, S100A1
3calcipotriol44 59 28 1112.7KRT15, KRT14
42-methoxyethanol449.6ACTC1, KRT14, S100A1
5reticulin449.4ACTC1, KRT7
62-chlorodeoxyadenosine449.3TP53, DNTT
7b 723449.1S100A1, KRT7, ACTC1
8retinoid448.9KRT14, KRT7, TP53
9mucicarmine448.9ACTC1, KRT7, KRT14, S100A1
10hematoxylin448.8S100A1, KRT14, KRT7, ACTC1
11iron44 249.7ACTC1, KRT7, KRT14, S100A1
12progesterone44 59 28 11 2412.4S100A1, KRT14, KRT7, ACTC1, TP53
13paraffin447.9S100A1, DNTT, KRT14, KRT7, ACTC1, TP53
14retinoic acid44 248.4S100A1, DNTT, KRT14, KRT7, KRT15, ACTC1

GO Terms for genes affiliated with Spiradenoma

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16Gene Ontology
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Cellular components related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.8KRT15, KRT7, KRT14

Products for genes affiliated with Spiradenoma

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Sources for Spiradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet