ES
MCID: SPR013
MIFTS: 40

Spiradenoma (ES) malady

Skin diseases category

Summaries for Spiradenoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

MalaCards: Spiradenoma, also known as eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)). The compounds hpvs and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and smooth muscle, and related mouse phenotype cellular.

Aliases & Classifications for Spiradenoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 60UMLS, 39NCIt, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

spiradenoma 8 10
eccrine spiradenoma 8 42 60
benign eccrine spiradenoma 8 42
eccrine spiradenoma, benign 42
eccrine spiradenoma of skin 8
es 42


External Ids:

Disease Ontology8 DOID:5444
SNOMED-CT56 4977000, 403938001
NCIt39 C4170

Related Diseases for Spiradenoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1brooke-spiegler syndrome30.6CYLD
2sarcoma30.4TP53, S100A1, ACTC1
3syringoma30.1S100A1, KRT14
4adenoid cystic carcinoma30.1S100A1, ACTC1, KRT7, KRT14, CYLD
5papillary carcinoma30.0KRT7, ACTC1, S100A1, KRT14
6hidradenoma29.9CLEC2A
7thymoma29.9DNTT
8glomus tumor29.9ACTC1, S100A1
9adenoma29.8KRT14, ACTC1, S100A1, KRT7, TP53
10endometrial carcinoma29.7KRT7, TP53
11breast cancer29.7KRT7, KRT14, TP53, ACTC1, S100A1, KRT15
12malignant spiradenoma10.8
13primitive neuroectodermal tumor10.2
14breast malignant eccrine spiradenoma10.2
15benign eccrine breast spiradenoma10.2
16adenoiditis10.2
17adnexal spiradenoma/cylindroma of a sweat gland10.2
18status epilepticus10.2
19neuronitis10.2
20thyroiditis10.2
21urinary schistosomiasis10.1
22schistosomiasis10.1
23sweat gland carcinoma10.1
24tetanus neonatorum10.0
25penis sarcoma10.0
26acute leukemia10.0
27cell type cancer10.0
28epithelioid sarcoma10.0
29extrapulmonary tuberculosis10.0
30filariasis10.0
31leukemia10.0
32malaria10.0
33pancreatitis10.0
34papillary thyroid carcinoma10.0
35tetanus10.0
36thyroid cancer10.0
37tuberculosis10.0
38keratosis10.0CLEC2A
39pilomatrixoma10.0CLEC2A
40paraganglioma10.0S100A1
41craniopharyngioma10.0KRT14
42epidermolysis bullosa10.0KRT14
43hidrocystoma10.0SGTA
44meningioma10.0S100A1
45cystadenoma10.0KRT7
46mixed cell type cancer10.0KRT7
47thymus cancer10.0KRT7
48nephroblastoma10.0TP53
49syringocystadenoma papilliferum10.0KRT15, CLEC2A
50epidermolysis bullosa simplex10.0KRT14

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to spiradenoma

Clinical Features for Spiradenoma

About this section

Drugs & Therapeutics for Spiradenoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Spiradenoma

Drug clinical trials:

Search ClinicalTrials for Spiradenoma

Search NIH Clinical Center for Spiradenoma

Search CenterWatch for Spiradenoma

Genetic Tests for Spiradenoma

About this section

Anatomical Context for Spiradenoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Spiradenoma:

32
Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Spiradenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.5TP53, ACTC1, KRT7, KRT14, CYLD, DNTT

Publications for Spiradenoma

About this section
Sources:
50PubMed
See all sources

Articles related to Spiradenoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Tubular Spitz Naevus Mimicking Eccrine Spiradenoma. (23756597)
2014
2
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. (24118397)
2013
3
Dermatoscopic pattern of a spiradenoma. (23785623)
2012
4
Malignant spiradenoma/cylindroma of the vulva. (23147883)
2012
5
Painful eccrine spiradenoma containing nerve fibers: a case report. (22777362)
2012
6
Malignant eccrine spiradenoma: a meta-analysis of reported cases. (20851376)
2011
7
Giant vascular eccrine spiradenoma. (22148049)
2011
8
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. (21430945)
2011
9
Carcinosarcoma ex eccrine spiradenoma of the vulva: report of the first case. (21464722)
2011
10
Alteration of the I^-catenin pathway in spiradenoma. (21518380)
2011
11
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. (20483125)
2010
12
A case of eccrine spiradenoma in a patient with neurofibromatosis. (20548911)
2010
13
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
14
An unusual case of congenital linear eccrine spiradenoma. (19419467)
2009
15
Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. (19194280)
2009
16
A case of eccrine spiradenoma arising in nevus sebaceous in an adolescent girl. (18360132)
2008
17
Malignant eccrine spiradenoma of the scalp. (19098562)
2008
18
Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: a clinicopathological study of 6 cases. (18806484)
2008
19
MRI appearance of multiple eccrine spiradenoma. (17267467)
2007
20
De novo malignant eccrine spiradenoma: a case report and review of the literature. (16970705)
2006
21
Spiradenocarcinoma of the breast arising in a long-standing spiradenoma. (15185264)
2004
22
Multiple eccrine spiradenoma in zosteriform distribution. (12960891)
2003
23
Linear spiradenoma with focal malignant transformation. (12702073)
2003
24
Eccrine spiradenoma of the ear: case report. (14636622)
2003
25
Malignant eccrine spiradenoma occurring on a traumatized area. (12087301)
2002
26
Eccrine spiradenoma. (17656951)
2002
27
Commentary on malignant eccrine spiradenoma. (11277909)
2001
28
Malignant mixed tumor ex eccrine spiradenoma: an unusual pattern of malignant dedifferentiation. (11436169)
2001
29
Guess what! Malignant eccrine spiradenoma. (10702011)
2000
30
Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. (10770427)
2000
31
Extensive naevoid eccrine spiradenoma. (10215788)
1999
32
Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. (10075300)
1999
33
Giant malignant eccrine spiradenoma of the scalp. (9935094)
1999
34
Malignant eccrine spiradenoma with florid squamous differentiation. (9610621)
1998
35
Malignant eccrine spiradenoma. Case report and review of the literature. (9391538)
1997
36
Spiradenoma associated with apocrine adenoma component. (9122033)
1996
37
An unusual case of early malignant transformation in a spiradenoma. (7633823)
1995
38
Perivascular spaces in eccrine spiradenoma. A clue to its histological diagnosis. (8599436)
1995
39
Malignant eccrine spiradenoma. A clinicopathologic study. (1384379)
1992
40
Eccrine spiradenoma: a report of malignant transformation. (1655199)
1991
41
Malignant eccrine spiradenoma of the hand. (2154644)
1990
42
Congenital spiradenoma. (2851273)
1988
43
Multiple eccrine spiradenoma: case report and review. (2846662)
1988
44
Eccrine spiradenoma: report of a case. (2845039)
1988
45
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
46
Multiple linear eccrine spiradenoma associated with multiple trichoepithelioma. (3038978)
1987
47
An unusual tumor of the female breast: combined eccrine and apocrine spiradenoma. (6310473)
1983
48
Carcinoma arising in eccrine spiradenoma. (445374)
1979
49
Proceedings: Dermal eccrine cylindroma, epithelioma adenoides cysticum of Brooke, and ecrine spiradenoma. (4375438)
1974
50
Malignant transformation of eccrine spiradenoma. (4341946)
1972

Genetic Variations for Spiradenoma

About this section

Expression for genes affiliated with Spiradenoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

About this section

Compounds for genes affiliated with Spiradenoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1hpvs449.9KRT14, TP53
2actomyosin449.7ACTC1, S100A1
3calcipotriol44 59 28 1112.7KRT15, KRT14
42-methoxyethanol449.6ACTC1, KRT14, S100A1
5reticulin449.4ACTC1, KRT7
62-chlorodeoxyadenosine449.3TP53, DNTT
7b 723449.1S100A1, KRT7, ACTC1
8retinoid448.9KRT14, KRT7, TP53
9mucicarmine448.9ACTC1, KRT7, KRT14, S100A1
10hematoxylin448.8S100A1, KRT14, KRT7, ACTC1
11iron44 249.7ACTC1, KRT7, KRT14, S100A1
12progesterone44 59 28 11 2412.4S100A1, KRT14, KRT7, ACTC1, TP53
13paraffin447.9S100A1, DNTT, KRT14, KRT7, ACTC1, TP53
14retinoic acid44 248.4S100A1, DNTT, KRT14, KRT7, KRT15, ACTC1

GO Terms for genes affiliated with Spiradenoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.8KRT15, KRT7, KRT14

Products for genes affiliated with Spiradenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spiradenoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet