ES
MCID: SPR013
MIFTS: 56

Spiradenoma (ES) malady

Rare diseases, Cancer diseases, Eye diseases, Skin diseases, Ear diseases categories
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Summaries for Spiradenoma

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MedlinePlus:33 Some eye problems are minor and don't last long. but some can lead to a permanent loss of vision. common eye problems include refractive errors cataracts - clouded lenses glaucoma - a disorder caused by damage to the optic nerve retinal disorders - problems with the nerve layer at the back of the eye macular degeneration - a disease that destroys sharp, central vision diabetic eye problems conjunctivitis - an infection also known as pinkeye your best defense is to have regular checkups, because eye diseases do not always have symptoms. early detection and treatment could prevent vision loss. see an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes of light. other symptoms that need quick attention are pain, double vision, fluid coming from the eye, and inflammation. nih: national eye institute

MalaCards based summary: Spiradenoma, also known as benign eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)), and among its related pathways are Glucocorticoid receptor regulatory network and Cytoskeleton remodeling Keratin filaments. The drugs prednisone and prednisone pwdr and the compounds hpvs and reticulin have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and breast, and related mouse phenotypes are cellular and normal.

Wikipedia:65 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Aliases & Classifications for Spiradenoma

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Spiradenoma, Aliases & Descriptions:

Name: Spiradenoma 8 10
Benign Eccrine Spiradenoma 8 42 62
Eccrine Spiradenoma 8 42 62
Eccrine Spiradenoma of Skin 8 62
Eye Diseases 44 33
 
Eye Disease 10 62
Eccrine Spiradenoma, Benign 42
Disorder of Eye 62
Es 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Eye diseases, Skin diseases, Ear diseases


External Ids:

Disease Ontology8 DOID:5444
SNOMED-CT57 403938001, 4977000
NCIt39 C4170

Related Diseases for Spiradenoma

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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1341)
idRelated DiseaseScoreTop Affiliating Genes
1brooke-spiegler syndrome31.5CYLD
2sarcoma30.5S100A1, ACTC1, TP53
3syringoma30.4KRT14, S100A1
4teratoma30.0KRT7, ACTC1
5peripheral primitive neuroectodermal tumor29.9S100A1, DNTT
6psoriasis29.4KRT15, KRT14, S100A1
7adenoma29.2TP53, ACTC1, S100A1, KRT14, KRT7
8melanoma29.0TP53, ACTC1, S100A1, KRT14
9breast cancer28.8TP53, ACTC1, S100A1, KRT14, KRT15, KRT7
10eye disease11.1
11fish-eye disease10.7
12malignant spiradenoma10.6
13meningioma10.5S100A1
14pseudomyxoma peritonei10.4KRT7
15aland island eye disease10.4
16age related macular degeneration10.4
17syringocystadenoma papilliferum10.4KRT15, CLEC2A
18cataract10.3
19neuroectodermal tumor10.3
20blindness10.3
21breast malignant eccrine spiradenoma10.3
22alopecia10.3KRT15, CLEC2A
23herpes simplex10.3
24keratitis10.3
25nephrogenic adenoma10.3KRT7, S100A1
26oxyphilic adenoma10.3KRT7, S100A1
27renal oncocytoma10.3KRT7, S100A1
28status epilepticus10.3
29thyroiditis10.3
30strabismus10.3
31cutaneous fibrous histiocytoma10.2S100A1, ACTC1
32benign eccrine breast spiradenoma10.2
33adenoiditis10.2
34adnexal spiradenoma/cylindroma of a sweat gland10.2
35dermatofibrosarcoma protuberans10.2S100A1, ACTC1
36hemangiopericytoma10.2S100A1, ACTC1
37angiomyolipoma10.2ACTC1, S100A1
38paraganglioma10.2ACTC1, S100A1
39fibroma10.2ACTC1, S100A1
40neuronitis10.2
41fibromatosis10.2ACTC1, S100A1
42smooth muscle tumor10.2ACTC1, S100A1
43malignant peripheral nerve sheath tumor10.2ACTC1, S100A1
44refractive error10.2
45neurofibroma10.2ACTC1, S100A1
46malignant fibroxanthoma10.2ACTC1, S100A1
47renal clear cell carcinoma10.2KRT7, S100A1
48spindle cell sarcoma10.2KRT7, ACTC1
49gastric cancer10.2
50malignant mesothelioma10.2KRT7, S100A1

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to spiradenoma

Symptoms for Spiradenoma

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Drugs & Therapeutics for Spiradenoma

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Drug clinical trials:

Search ClinicalTrials for Spiradenoma

Search NIH Clinical Center for Spiradenoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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MalaCards organs/tissues related to Spiradenoma:

32
Eye, Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

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MGI Mouse Phenotypes related to Spiradenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.5TP53, ACTC1, KRT14, KRT7, CYLD
2MP:00028738.0S100A1, DNTT, ACTC1, TP53, CYLD

Publications for Spiradenoma

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Articles related to Spiradenoma:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. (25354097)
2014
2
Differential diagnosis of eccrine spiradenoma: A case report. (25187803)
2014
3
Eccrine spiradenoma in knee. (25284865)
2014
4
Cystic eccrine spiradenoma of the finger mimicking a ganglion. (25289292)
2014
5
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. (24118397)
2013
6
Dermatoscopic pattern of a spiradenoma. (23785623)
2012
7
Malignant eccrine spiradenoma: a meta-analysis of reported cases. (20851376)
2011
8
Giant vascular eccrine spiradenoma. (22148049)
2011
9
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. (21430945)
2011
10
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. (19222500)
2010
11
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)
2010
12
Spiradenoma with marked adenomyoepitheliomatous features. (20859082)
2010
13
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. (20483125)
2010
14
Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. (19684510)
2009
15
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
16
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. (20101314)
2009
17
Multiple nodules of the head--clinicopathologic challenge. Multiple eccrine spiradenoma. (19261009)
2009
18
Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)
2009
19
Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. (19454360)
2009
20
Recurrent atypical eccrine spiradenoma of the forehead. (19181014)
2008
21
MRI appearance of multiple eccrine spiradenoma. (17267467)
2007
22
Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)
2007
23
Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. (16479087)
2006
24
Congenital blaschkoid eccrine spiradenoma on the face. (15757814)
2005
25
Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. (15869542)
2005
26
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
27
Spiradenocarcinoma of the breast arising in a long-standing spiradenoma. (15185264)
2004
28
Eccrine spiradenoma: an unusual presentation with otalgia. (14990930)
2004
29
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. (14989745)
2004
30
Papular lesion of the proximal nail fold. Eccrine spiradenoma. (15313820)
2004
31
Familial eccrine spiradenoma: a case report and review of the literature. (12656824)
2003
32
Multiple eccrine spiradenoma in zosteriform distribution. (12960891)
2003
33
Malignant eccrine spiradenoma occurring on a traumatized area. (12087301)
2002
34
Extensive naevoid eccrine spiradenoma. (10215788)
1999
35
Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review. (10535577)
1999
36
Eccrine spiradenoma mimicking adenoid cystic carcinoma on fine needle aspiration. A case report. (9167714)
1997
37
Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. (8639057)
1996
38
Cutaneous adnexal carcinoma arising within a solitary cylindroma-spiradenoma. (8721596)
1996
39
Eccrine spiradenoma, not poroma. (8634818)
1996
40
An unusual, recurring breast tumor with features of eccrine spiradenoma: a case report. (8929479)
1996
41
Over-expression of p53 protein as an indicator of the malignant transformation in spiradenoma. (7657312)
1995
42
Stump the experts. Eccrine spiradenoma. (8388416)
1993
43
Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach. (1322262)
1992
44
Congenital spiradenoma. (2851273)
1988
45
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
46
Eccrine spiradenoma: clinical and pathologic study of 49 tumors. (6313776)
1983
47
An unusual tumor of the female breast: combined eccrine and apocrine spiradenoma. (6310473)
1983
48
Carcinoma arising in eccrine spiradenoma. (445374)
1979
49
Proceedings: Dermal eccrine cylindroma, epithelioma adenoides cysticum of Brooke, and ecrine spiradenoma. (4375438)
1974
50
Eccrine spiradenoma. Histochemical and electron microscopic studies. (4286974)
1966

Variations for Spiradenoma

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Expression for genes affiliated with Spiradenoma

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Expression patterns in normal tissues for genes affiliated with Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

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Pathways related to Spiradenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KRT14, TP53
29.6KRT7, KRT14
39.2KRT15, TP53

Compounds for genes affiliated with Spiradenoma

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Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1hpvs4410.0KRT14, TP53
2reticulin449.9KRT7, ACTC1
3actomyosin449.8S100A1, ACTC1
42-chlorodeoxyadenosine449.6DNTT, TP53
5methanol44 2410.6KRT7, ACTC1
62-methoxyethanol449.6KRT14, S100A1, ACTC1
7dutp449.6DNTT, TP53
8calcipotriol44 61 28 1112.5KRT15, KRT14
9carboplatin44 50 1111.4DNTT, TP53
10retinoid449.4TP53, KRT14, KRT7
11b 723449.4ACTC1, S100A1, KRT7
12fludarabine44 50 1111.3DNTT, TP53
13butyrate449.3TP53, DNTT, KRT14
14glycogen44 2410.2ACTC1, S100A1, KRT7
15mucicarmine449.1KRT7, KRT14, S100A1, ACTC1
16hematoxylin449.0ACTC1, S100A1, KRT14, KRT7
17iron44 2410.0ACTC1, S100A1, KRT14, KRT7
18cisplatin44 50 61 1111.8TP53, DNTT, KRT14
19progesterone44 28 61 24 1112.6TP53, ACTC1, S100A1, KRT14, KRT7
20estrogen448.6KRT7, KRT14, S100A1, ACTC1, TP53
21tyrosine448.1KRT7, KRT15, KRT14, S100A1, ACTC1
22paraffin448.0TP53, ACTC1, DNTT, S100A1, KRT14, KRT7
23retinoic acid44 248.2TP53, ACTC1, DNTT, S100A1, KRT14, KRT15

GO Terms for genes affiliated with Spiradenoma

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Cellular components related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.6KRT7, KRT14
2intermediate filamentGO:0058828.5KRT7, KRT15, KRT14

Biological processes related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:0085449.3KRT15, KRT14

Molecular functions related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3KRT15, KRT14
2protein bindingGO:0055156.7KRT7, KRT15, KRT14, S100A1, CLEC2A, TP53

Products for genes affiliated with Spiradenoma

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  • Antibodies
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Sources for Spiradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet