Spiradenoma malady

Wikipedia: Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically...⁴⁴ more...

MalaCards: Spiradenoma, also known as benign eccrine spiradenoma, is related to carcinoma and brooke-spiegler syndrome. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)). The compounds retinoic acid and calcipotriol have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and skin.

Aliases & Descriptions:

spiradenoma 6 8 benign eccrine spiradenoma 6 30 eccrine spiradenoma 30 43 eccrine spiradenoma (morphologic abnormality) 6

eccrine spiradenoma of skin 6 eccrine spiradenoma, benign 30 es 30

Diseases related to spiradenoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 401)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	28.4	TP53, KRT14, ACTC1, DNTT, CYLD, KRT7
2	brooke-spiegler syndrome	27.5	CYLD, TP53, KRT7
3	thymoma	27.2	DNTT, TP53, KRT7
4	prostatitis	27.0	S100A1, SGTA, TP53, KRT7, KRT15, KRT14
5	squamous cell carcinoma	26.9	S100A1, ACTC1, KRT7, KRT15, KRT14, TP53
6	thyroiditis	26.8	DNTT, KRT7, TP53, KRT15, KRT14, ACTC1
7	cholesteatoma	26.5	KRT14, S100A1, TP53
8	neuroectodermal tumors	26.5	S100A1, TP53, DNTT
9	sarcoma	26.4	KRT7, KRT15, ACTC1, DNTT, KRT14, S100A1
10	neurofibromatosis	26.1	KRT14, TP53, ACTC1
11	epidermolysis bullosa simplex	26.0	KRT14, KRT15
12	hepatocellular carcinoma	25.9	DNTT, KRT7, TP53, CYLD, ACTC1, KRT14
13	renal cell carcinoma	25.7	KRT14, ACTC1, KRT7, S100A1
14	large cell carcinoma	25.5	KRT7, TP53
15	epidermolysis bullosa	25.5	KRT14, TP53, KRT15
16	breast carcinoma	25.3	KRT7, TP53, S100A1, ACTC1, KRT14, KRT15
17	meningioma	25.2	S100A1, ACTC1, KRT7, TP53
18	melanoma	25.0	KRT15, S100A1, KRT14, ACTC1, TP53, KRT7
19	carcinoid tumors	24.9	KRT7, TP53, ACTC1
20	endometrial adenocarcinoma	24.8	TP53, S100A1, KRT7
21	leiomyosarcoma	24.8	ACTC1, S100A1, TP53
22	tonsillitis	24.7	DNTT, S100A1, TP53
23	idiopathic pulmonary fibrosis	24.7	S100A1, TP53, ACTC1
24	basal cell carcinoma	24.5	KRT7, ACTC1, KRT15, TP53
25	adenocarcinoma	24.5	KRT7, KRT14, ACTC1, DNTT, KRT15, DKK2
26	sinusitis	24.2	TP53, KRT7, ACTC1, S100A1
27	psoriasis	24.2	TP53, DNTT, KRT14, KRT15, S100A1
28	vaginitis	24.1	TP53, ACTC1, KRT14
29	prostate carcinoma	23.6	S100A1, TP53, KRT7, ACTC1, DNTT
30	breast fibroadenoma	13.1	KRT14, KRT15
31	primary malignant lymphoma	13.1	DNTT, TP53
32	bowen syndrome	13.1	KRT7, KRT14
33	mammary paget's disease	13.0	KRT14, KRT7
34	myoma	13.0	KRT15, ACTC1
35	malignant mixed mullerian tumor	13.0	TP53, KRT7
36	hidradenocarcinoma	13.0	TP53, KRT7
37	ovarian mucinous adenocarcinoma	13.0	KRT7, TP53
38	pleomorphic carcinoma	13.0	KRT14, TP53
39	bile duct adenoma	13.0	KRT7, TP53
40	ovarian mucinous neoplasm	13.0	KRT7, TP53
41	adenoameloblastoma	13.0	KRT7, KRT14
42	parathyroid carcinoma	12.9	TP53, KRT14
43	spindle cell sarcoma	12.9	KRT7, TP53
44	follicular dendritic cell tumor	12.9	DNTT, ACTC1
45	hidrocystoma	12.9	KRT7, KRT15, SGTA
46	benign metastasizing leiomyoma	12.9	ACTC1, KRT7
47	cystic nephroma	12.9	ACTC1, KRT7
48	horseshoe kidney	12.9	ACTC1, KRT7
49	thymic epithelial tumor	12.9	DNTT, TP53
50	glomangioma	12.9	ACTC1, S100A1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spiradenoma:

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Articles related to spiradenoma:

id	Title	Authors	Year	Affiliating Genes
1	Expression of p53 and TP53 mutational analysis in mal ignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenoc ylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)	Kazakov D.V.... Michal M.	2010	TP53
2	Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the st udy of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndro me. (19194280)	Kazakov D.V.... Michal M.	2009	CYLD
3	Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)	Levidou G.... Androulaki A.	2009	DNTT
4	Skin type spiradenoma of the parotid gland with malig nant transformation: report of a case with analysis of the CYLD gene. (19454360)	Kazakov D.V.... Skalova A.	2009	CYLD
5	Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)	Kurokawa I.... Tsubura A.	2007	ACTC1
6	Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. (9129700)	Meybehm M.... Fischer H.P.	1997	KRT14, KRT7
7	Malignant transformation in multiple eccrine spiradenoma (1317754)	Husek K.... SamohA1l J.	1992	KRT7, S100A1

Genes related to spiradenoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CYLD	cylindromatosis (turban tumor syndrome)	11.0	Publications
2	SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	11.0
3	KRT15	keratin 15	11.0
4	KRT14	keratin 14	11.0	Publications
5	KRT7	keratin 7	11.0	Publications
6	S100A1	S100 calcium binding protein A1	11.0	Publications
7	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
8	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
9	DKK2	dickkopf 2 homolog (Xenopus laevis)	11.0
10	TP53	tumor protein p53	11.0	Publications

Compounds related to spiradenoma according to GeneDecks:

(show all 15)

id	Compound	Score	Top Affiliating Genes
1	retinoic acid32 42 18	12.0	KRT7, KRT15
2	calcipotriol32 42 9 9	12.8	KRT15, KRT14
3	hpvs32	9.7	TP53, KRT14
4	reticulin32	9.5	ACTC1, KRT7
5	2-chlorodeoxyadenosine32	9.4	TP53, DNTT
6	2-methoxyethanol32	9.3	ACTC1, KRT14, S100A1
7	b 72332	9.2	S100A1, KRT7, ACTC1
8	estrogen32	9.2	ACTC1, KRT14, S100A1
9	actomyosin32	9.1	S100A1, ACTC1
10	retinoid32	9.1	KRT14, KRT7, TP53
11	mucicarmine32	8.9	S100A1, KRT7, KRT14, ACTC1
12	hematoxylin32	8.9	ACTC1, KRT14, KRT7, S100A1
13	iron32 18	9.8	S100A1, KRT7, KRT14, ACTC1
14	progesterone32 42 9 18 9	12.3	ACTC1, KRT14, KRT7, TP53, S100A1
15	paraffin32	7.9	DNTT, ACTC1, KRT14, KRT7, TP53, S100A1

Cellular components related to spiradenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	9.3	KRT7, KRT15, KRT14