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MCID: SPR013
MIFTS: 38

Spiradenoma (ES) malady

Skin category
11 genes, 3 tissues, 127 related diseases, clinical trials.

Summaries for Spiradenoma

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Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

MalaCards: Spiradenoma, also known as eccrine spiradenoma, is related to brooke-spiegler syndrome and syringoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)). The compounds hpvs and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, breast and skin, and related mouse phenotype cellular.

Aliases & Classifications for Spiradenoma

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

spiradenoma 8 10
eccrine spiradenoma 8 43 61
benign eccrine spiradenoma 8 43
eccrine spiradenoma, benign 43
eccrine spiradenoma of skin 8
es 43


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Disease Ontology8 DOID:5444
SNOMED-CT57 4977000, 403938001
NCIt40 C4170

Related Diseases for Spiradenoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Spiradenoma family:

malignant spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1brooke-spiegler syndrome30.7CYLD
2syringoma30.1S100A1, KRT14
3adenoid cystic carcinoma30.1S100A1, ACTC1, KRT7, KRT14, CYLD
4adenoma30.1KRT14, ACTC1, S100A1, KRT7, TP53
5papillary carcinoma30.0KRT7, ACTC1, S100A1, KRT14
6thymoma29.9DNTT
7teratoma29.8ACTC1, KRT7
8malignant spiradenoma10.8
9breast malignant eccrine spiradenoma10.3
10status epilepticus10.2
11benign eccrine breast spiradenoma10.2
12n syndrome10.2
13adnexal spiradenoma/cylindroma of a sweat gland10.2
14dermal eccrine cylindroma10.2
15malignant cylindroma10.2
16urinary schistosomiasis10.1
17sweat gland carcinoma10.1
18tetanus neonatorum10.1
19acute t cell leukemia10.1
20penis sarcoma10.1
21acute leukemia10.1
22t-cell leukemia10.1
23tetanus10.1
24thyroid cancer10.1
25tuberculosis10.1
26diffuse gastric cancer10.1
27síndrome x frágil10.1
28keratosis10.0CLEC2A
29pilomatrixoma10.0CLEC2A
30paraganglioma10.0S100A1
31craniopharyngioma10.0KRT14
32hidradenoma10.0CLEC2A
33epidermolysis bullosa10.0KRT14
34hidrocystoma10.0SGTA
35meningioma10.0S100A1
36cystadenoma10.0KRT7
37mixed cell type cancer10.0KRT7
38thymic carcinoma10.0KRT7
39nephroblastoma10.0TP53
40syringocystadenoma papilliferum10.0KRT15, CLEC2A
41epidermolysis bullosa simplex10.0KRT14
42alopecia10.0CLEC2A, KRT15
43angiomyolipoma10.0S100A1, ACTC1
44desmoid tumor10.0ACTC1
45dermatofibrosarcoma protuberans10.0ACTC1, S100A1
46smooth muscle tumor10.0ACTC1, S100A1
47cholesteatoma10.0S100A1, KRT14
48fibromatosis10.0S100A1, ACTC1
49cutaneous fibrous histiocytoma10.0ACTC1, S100A1
50renal oncocytoma10.0S100A1, KRT7

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to spiradenoma

Clinical Features for Spiradenoma

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Drugs & Therapeutics for Spiradenoma

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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33MalaCards
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MalaCards organs/tissues related to Spiradenoma:

33
Smooth muscle, Breast, Skin

Animal Models for Spiradenoma or affiliated genes

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Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Spiradenoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
cellular phenotype
MP:00053847.5TP53, ACTC1, KRT7, KRT14, CYLD, DNTT

Publications for Spiradenoma

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Sources:
51PubMed
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Articles related to Spiradenoma:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Giant vascular eccrine spiradenoma mimicking calcifying epithelioma. (23961898)
2013
2
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma and eccrine spiradenoma. (24261740)
2013
3
Neonatal spiradenoma. (22747799)
2013
4
A rare case of giant malignant eccrine spiradenoma. (21342314)
2011
5
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression. (21598248)
2011
6
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. (19222500)
2010
7
Malignant eccrine spiradenoma: a new case report. (19614990)
2010
8
Multiple nodules of the head--clinicopathologic challenge. Multiple eccrine spiradenoma. (19261009)
2009
9
Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)
2009
10
Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. (19454360)
2009
11
Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. (19633533)
2009
12
Recurrent atypical eccrine spiradenoma of the forehead. (19181014)
2008
13
Giant eccrine spiradenoma of the hand. (18836612)
2008
14
Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)
2007
15
Malignant eccrine spiradenoma. (17474253)
2007
16
Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. (16479087)
2006
17
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
18
Eccrine spiradenoma: an unusual presentation with otalgia. (14990930)
2004
19
Papular lesion of the proximal nail fold. Eccrine spiradenoma. (15313820)
2004
20
Two cases of multiple eccrine spiradenoma with linear or localized formation. (15492423)
2004
21
Malignant eccrine spiradenoma of the neck: a case report. (11593191)
2001
22
Spiradenocylindromas of the skin: tumors with morphological features of spiradenoma and cylindroma in the same lesion: report of 12 cases. (10417685)
1999
23
Eccrine spiradenoma mimicking adenoid cystic carcinoma on fine needle aspiration. A case report. (9167714)
1997
24
Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements. (9462275)
1997
25
Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. (9129700)
1997
26
Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. (8639057)
1996
27
An unusual, recurring breast tumor with features of eccrine spiradenoma: a case report. (8929479)
1996
28
Dermal cylindroma and eccrine spiradenoma. (8936072)
1996
29
Over-expression of p53 protein as an indicator of the malignant transformation in spiradenoma. (7657312)
1995
30
Stump the experts. Eccrine spiradenoma. (8388416)
1993
31
Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach. (1322262)
1992
32
Malignant transformation in multiple eccrine spiradenoma]. (1317754)
1992
33
Cytogenetics of a case of eccrine spiradenoma. (1325410)
1992
34
Carcinosarcoma arising in eccrine spiradenoma. A clinicopathologic and immunohistochemical study of two cases. (2168130)
1990
35
Eccrine spiradenoma occurring in infancy mimicking mesenchymal tumor. (1697611)
1990
36
Fine needle aspiration cytology of malignant spiradenoma arising in congenital eccrine spiradenoma. (2157326)
1990
37
Eccrine spiradenoma. An electron microscopic study. (2847575)
1987
38
Malignant transformation of eccrine spiradenoma. (2996443)
1985
39
Eccrine spiradenoma (a case report). (6100593)
1984
40
Sweat gland carcinoma of the hand: two cases of malignant eccrine spiradenoma. (6096437)
1984
41
Eccrine spiradenoma: clinical and pathologic study of 49 tumors. (6313776)
1983
42
Pathology quiz case 2. Eccrine spiradenoma. (6284064)
1982
43
Cylindroma and eccrine spiradenoma coexistent in the same lesion. (6279036)
1982
44
Spiradenoma. Histochemical and electron microscopic study. (4358394)
1974
45
Eccrine spiradenoma. (4103044)
1971
46
Eccrine spiradenoma. (4168808)
1967
47
Eccrine spiradenoma. Histochemical and electron microscopic studies. (4286974)
1966
48
A light- and electron-microscopic study of a case of multiple eccrine spiradenoma. (14477202)
1962
49
An unusual tumor of the breast resembling eccrine spiradenoma. (13661107)
1959
50
Eccrine spiradenoma; report of a case and preliminary pharmacologic studies. (13423892)
1957

Genetic Variations for Spiradenoma

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Expression for genes affiliated with Spiradenoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spiradenoma

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Pathways for genes affiliated with Spiradenoma

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Compounds for genes affiliated with Spiradenoma

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Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1hpvs459.9KRT14, TP53
2actomyosin459.7ACTC1, S100A1
3calcipotriol45 60 29 1112.7KRT15, KRT14
42-methoxyethanol459.6ACTC1, KRT14, S100A1
5reticulin459.4ACTC1, KRT7
62-chlorodeoxyadenosine459.3TP53, DNTT
7b 723459.1S100A1, KRT7, ACTC1
8retinoid458.9KRT14, KRT7, TP53
9mucicarmine458.9ACTC1, KRT7, KRT14, S100A1
10hematoxylin458.8S100A1, KRT14, KRT7, ACTC1
11iron45 249.7ACTC1, KRT7, KRT14, S100A1
12progesterone45 60 29 11 2412.4S100A1, KRT14, KRT7, ACTC1, TP53
13paraffin457.9S100A1, DNTT, KRT14, KRT7, ACTC1, TP53
14retinoic acid45 248.4S100A1, DNTT, KRT14, KRT7, KRT15, ACTC1

GO Terms for genes affiliated with Spiradenoma

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16Gene Ontology
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Cellular components related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.8KRT15, KRT7, KRT14

Products for genes affiliated with Spiradenoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spiradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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