ES
MCID: SPR013
MIFTS: 40

Spiradenoma (ES) malady

Skin diseases category

Summaries for Spiradenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

MalaCards: Spiradenoma, also known as eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)). The compounds hpvs and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and smooth muscle, and related mouse phenotype cellular.

Aliases & Classifications for Spiradenoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

spiradenoma 8 10
eccrine spiradenoma 8 42 60
benign eccrine spiradenoma 8 42
eccrine spiradenoma, benign 42
eccrine spiradenoma of skin 8
es 42


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Disease Ontology8 DOID:5444
SNOMED-CT56 4977000, 403938001
NCIt39 C4170

Related Diseases for Spiradenoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1brooke-spiegler syndrome30.6CYLD
2sarcoma30.4TP53, S100A1, ACTC1
3syringoma30.1S100A1, KRT14
4adenoid cystic carcinoma30.1S100A1, ACTC1, KRT7, KRT14, CYLD
5papillary carcinoma30.0KRT7, ACTC1, S100A1, KRT14
6hidradenoma29.9CLEC2A
7thymoma29.9DNTT
8glomus tumor29.9ACTC1, S100A1
9adenoma29.8KRT14, ACTC1, S100A1, KRT7, TP53
10endometrial carcinoma29.7KRT7, TP53
11breast cancer29.7KRT7, KRT14, TP53, ACTC1, S100A1, KRT15
12malignant spiradenoma10.8
13primitive neuroectodermal tumor10.2
14breast malignant eccrine spiradenoma10.2
15benign eccrine breast spiradenoma10.2
16adenoiditis10.2
17adnexal spiradenoma/cylindroma of a sweat gland10.2
18status epilepticus10.2
19neuronitis10.2
20thyroiditis10.2
21urinary schistosomiasis10.1
22schistosomiasis10.1
23sweat gland carcinoma10.1
24tetanus neonatorum10.0
25penis sarcoma10.0
26acute leukemia10.0
27cell type cancer10.0
28epithelioid sarcoma10.0
29extrapulmonary tuberculosis10.0
30filariasis10.0
31leukemia10.0
32malaria10.0
33pancreatitis10.0
34papillary thyroid carcinoma10.0
35tetanus10.0
36thyroid cancer10.0
37tuberculosis10.0
38keratosis10.0CLEC2A
39pilomatrixoma10.0CLEC2A
40paraganglioma10.0S100A1
41craniopharyngioma10.0KRT14
42epidermolysis bullosa10.0KRT14
43hidrocystoma10.0SGTA
44meningioma10.0S100A1
45cystadenoma10.0KRT7
46mixed cell type cancer10.0KRT7
47thymus cancer10.0KRT7
48nephroblastoma10.0TP53
49syringocystadenoma papilliferum10.0KRT15, CLEC2A
50epidermolysis bullosa simplex10.0KRT14

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to spiradenoma

Clinical Features for Spiradenoma

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Drugs & Therapeutics for Spiradenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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32MalaCards
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MalaCards organs/tissues related to Spiradenoma:

32
Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Spiradenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.5TP53, ACTC1, KRT7, KRT14, CYLD, DNTT

Publications for Spiradenoma

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Sources:
50PubMed
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Articles related to Spiradenoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Giant vascular eccrine spiradenoma mimicking calcifying epithelioma. (23961898)
2013
2
Differential considerations of skin tumours with florid vascularisation: report of a solitary giant vascular eccrine spiradenoma. (22689604)
2011
3
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. (19222500)
2010
4
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)
2010
5
Spiradenoma with marked adenomyoepitheliomatous features. (20859082)
2010
6
Malignant eccrine spiradenoma: a new case report. (19614990)
2010
7
Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. (19684510)
2009
8
Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. (19454360)
2009
9
Glomus tumor mimicking eccrine spiradenoma on fine needle aspiration. (21938152)
2009
10
A case of giant vascular eccrine spiradenoma with unusual clinical features. (19323658)
2009
11
Giant eccrine spiradenoma of the hand. (18836612)
2008
12
Sonographic findings of an eccrine spiradenoma: case report and literature review. (18424661)
2008
13
A painless punctured papule. Diagnosis: Eccrine spiradenoma. (19052437)
2008
14
Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. (16479087)
2006
15
Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. (16803551)
2006
16
Congenital blaschkoid eccrine spiradenoma on the face. (15757814)
2005
17
Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. (15869542)
2005
18
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
19
Eccrine spiradenoma: an unusual presentation with otalgia. (14990930)
2004
20
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. (14989745)
2004
21
Papular lesion of the proximal nail fold. Eccrine spiradenoma. (15313820)
2004
22
Familial eccrine spiradenoma: a case report and review of the literature. (12656824)
2003
23
Low-grade malignant eccrine spiradenoma with systemic metastases. (12775989)
2003
24
Malignant eccrine spiradenoma. (11958666)
2002
25
Malignant eccrine spiradenoma: a case report and review of the literature. (11231249)
2001
26
Malignant spiradenoma: report of two cases and literature review. (11174426)
2001
27
Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review. (10535577)
1999
28
Giant vascular eccrine spiradenoma. (9556114)
1998
29
Eccrine spiradenoma mimicking adenoid cystic carcinoma on fine needle aspiration. A case report. (9167714)
1997
30
Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. (9129700)
1997
31
Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. (8639057)
1996
32
Cutaneous adnexal carcinoma arising within a solitary cylindroma-spiradenoma. (8721596)
1996
33
Dermal cylindroma and eccrine spiradenoma. (8936072)
1996
34
Eccrine spiradenoma of the hand clinically mimicking a lipoma. (8856552)
1996
35
Malignant eccrine spiradenoma with smooth muscle cell differentiation: histological and immunohistochemical study. (8970199)
1996
36
Zosteriform network of spiradenoma. (20948035)
1996
37
Immunohistochemical analysis of cytokeratin expression in eccrine spiradenoma: similarities to the transitional portions between secretory segments and coiled ducts of eccrine glands. (7532000)
1994
38
An uncommon breast tumour: the malignant eccrine spiradenoma. A case report. (8140844)
1993
39
Spiradenomas in Brooke-Spiegler syndrome. (7684205)
1993
40
Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach. (1322262)
1992
41
Malignant transformation in multiple eccrine spiradenoma]. (1317754)
1992
42
Non-epithelial cellular components in eccrine spiradenoma: a histological and immunohistochemical study of 20 cases. (1849119)
1991
43
Fine needle aspiration cytology of malignant spiradenoma arising in congenital eccrine spiradenoma. (2157326)
1990
44
Multiple familial eccrine spiradenoma with cylindroma. (1967884)
1990
45
Eccrine spiradenoma of eyelid: case report. (3017404)
1986
46
Sweat gland carcinoma of the hand: two cases of malignant eccrine spiradenoma. (6096437)
1984
47
Eccrine spiradenoma and dermal cylindroma. (6302142)
1983
48
Spiradenoma. Histochemical and electron microscopic study. (4358394)
1974
49
Eccrine spiradenoma. (4168808)
1967
50
Histochemistry of hidradenoma and eccrine spiradenoma. (4292174)
1967

Genetic Variations for Spiradenoma

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Expression for genes affiliated with Spiradenoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

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Compounds for genes affiliated with Spiradenoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1hpvs449.9KRT14, TP53
2actomyosin449.7ACTC1, S100A1
3calcipotriol44 59 28 1112.7KRT15, KRT14
42-methoxyethanol449.6ACTC1, KRT14, S100A1
5reticulin449.4ACTC1, KRT7
62-chlorodeoxyadenosine449.3TP53, DNTT
7b 723449.1S100A1, KRT7, ACTC1
8retinoid448.9KRT14, KRT7, TP53
9mucicarmine448.9ACTC1, KRT7, KRT14, S100A1
10hematoxylin448.8S100A1, KRT14, KRT7, ACTC1
11iron44 249.7ACTC1, KRT7, KRT14, S100A1
12progesterone44 59 28 11 2412.4S100A1, KRT14, KRT7, ACTC1, TP53
13paraffin447.9S100A1, DNTT, KRT14, KRT7, ACTC1, TP53
14retinoic acid44 248.4S100A1, DNTT, KRT14, KRT7, KRT15, ACTC1

GO Terms for genes affiliated with Spiradenoma

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16Gene Ontology
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Cellular components related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.8KRT15, KRT7, KRT14

Products for genes affiliated with Spiradenoma

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Sources for Spiradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet