Spiradenoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Spiradenoma

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⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

MalaCards: Spiradenoma, also known as eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)). The compounds hpvs and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and smooth muscle, and related mouse phenotype cellular.

Aliases & Classifications for Spiradenoma

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ¹⁰DISEASES, ⁶⁰UMLS, ³⁹NCIt, ⁵⁶SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases

Aliases & Descriptions:

spiradenoma ⁸ ¹⁰

eccrine spiradenoma ⁸ ⁴² ⁶⁰

benign eccrine spiradenoma ⁸ ⁴²

eccrine spiradenoma, benign ⁴²

eccrine spiradenoma of skin ⁸

es ⁴²

External Ids:

Disease Ontology⁸ DOID:5444

SNOMED-CT⁵⁶ 4977000, 403938001

NCIt³⁹ C4170

UMLS⁶⁰ C1332494, C0334347

Related Diseases for Spiradenoma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 148)

id	Related Disease	Score	Top Affiliating Genes
1	brooke-spiegler syndrome	30.6	CYLD
2	sarcoma	30.4	TP53, S100A1, ACTC1
3	syringoma	30.1	S100A1, KRT14
4	adenoid cystic carcinoma	30.1	S100A1, ACTC1, KRT7, KRT14, CYLD
5	papillary carcinoma	30.0	KRT7, ACTC1, S100A1, KRT14
6	hidradenoma	29.9	CLEC2A
7	thymoma	29.9	DNTT
8	glomus tumor	29.9	ACTC1, S100A1
9	adenoma	29.8	KRT14, ACTC1, S100A1, KRT7, TP53
10	endometrial carcinoma	29.7	KRT7, TP53
11	breast cancer	29.7	KRT7, KRT14, TP53, ACTC1, S100A1, KRT15
12	malignant spiradenoma	10.8
13	primitive neuroectodermal tumor	10.2
14	breast malignant eccrine spiradenoma	10.2
15	benign eccrine breast spiradenoma	10.2
16	adenoiditis	10.2
17	adnexal spiradenoma/cylindroma of a sweat gland	10.2
18	status epilepticus	10.2
19	neuronitis	10.2
20	thyroiditis	10.2
21	urinary schistosomiasis	10.1
22	schistosomiasis	10.1
23	sweat gland carcinoma	10.1
24	tetanus neonatorum	10.0
25	penis sarcoma	10.0
26	acute leukemia	10.0
27	cell type cancer	10.0
28	epithelioid sarcoma	10.0
29	extrapulmonary tuberculosis	10.0
30	filariasis	10.0
31	leukemia	10.0
32	malaria	10.0
33	pancreatitis	10.0
34	papillary thyroid carcinoma	10.0
35	tetanus	10.0
36	thyroid cancer	10.0
37	tuberculosis	10.0
38	keratosis	10.0	CLEC2A
39	pilomatrixoma	10.0	CLEC2A
40	paraganglioma	10.0	S100A1
41	craniopharyngioma	10.0	KRT14
42	epidermolysis bullosa	10.0	KRT14
43	hidrocystoma	10.0	SGTA
44	meningioma	10.0	S100A1
45	cystadenoma	10.0	KRT7
46	mixed cell type cancer	10.0	KRT7
47	thymus cancer	10.0	KRT7
48	nephroblastoma	10.0	TP53
49	syringocystadenoma papilliferum	10.0	KRT15, CLEC2A
50	epidermolysis bullosa simplex	10.0	KRT14

Graphical network of the top 20 diseases related to Spiradenoma:

Clinical Features for Spiradenoma

Drugs & Therapeutics for Spiradenoma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spiradenoma

Anatomical Context for Spiradenoma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Spiradenoma:

³²

Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Spiradenoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	7.5	TP53, ACTC1, KRT7, KRT14, CYLD, DNTT

Publications for Spiradenoma

Sources:
⁵⁰PubMed
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Articles related to Spiradenoma:

(show top 50) (show all 137)

id	Title	Authors	Year
1	Giant vascular eccrine spiradenoma mimicking calcifying epithelioma. (23961898)	Hatano A.... Hayakawa K.	2013
2	Differential considerations of skin tumours with florid vascularisation: report of a solitary giant vascular eccrine spiradenoma. (22689604)	Tremezaygues L.L.... MA1ller C.S.	2011
3	Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. (19222500)	Tanese K.... Ishiko A.	2010
4	Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)	Kazakov D.V.... Michal M.	2010
5	Spiradenoma with marked adenomyoepitheliomatous features. (20859082)	Kacerovska D.... Michal M.	2010
6	Malignant eccrine spiradenoma: a new case report. (19614990)	Ben Brahim E.... Chatti S.	2010
7	Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. (19684510)	Jukic D.M.... Davie J.R.	2009
8	Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. (19454360)	Kazakov D.V.... Skalova A.	2009
9	Glomus tumor mimicking eccrine spiradenoma on fine needle aspiration. (21938152)	Vidyavathi K.... Harendra K.M.	2009
10	A case of giant vascular eccrine spiradenoma with unusual clinical features. (19323658)	Yamakoshi T.... Shimizu T.	2009
11	Giant eccrine spiradenoma of the hand. (18836612)	Siegel H.J.... Klein M.	2008
12	Sonographic findings of an eccrine spiradenoma: case report and literature review. (18424661)	Jin W.... Ryu K.N.	2008
13	A painless punctured papule. Diagnosis: Eccrine spiradenoma. (19052437)	Verma S.	2008
14	Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. (16479087)	Ko J.Y.... Park C.K.	2006
15	Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. (16803551)	Chase D.M.... Berman M.L.	2006
16	Congenital blaschkoid eccrine spiradenoma on the face. (15757814)	Ekmekci T.R.... Sakiz D.	2005
17	Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. (15869542)	Bumgardner A.C.... Schwartz M.R.	2005
18	Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)	Uede K.... Furukawa F.	2004
19	Eccrine spiradenoma: an unusual presentation with otalgia. (14990930)	Nadig S.K.... Rao T.J.	2004
20	Malignant eccrine spiradenoma: a case report with pulmonary metastasis. (14989745)	Chou S.C.... Tseng H.H.	2004
21	Papular lesion of the proximal nail fold. Eccrine spiradenoma. (15313820)	Leach B.C.... Graham B.S.	2004
22	Familial eccrine spiradenoma: a case report and review of the literature. (12656824)	Ter Poorten M.C.... Cook J.	2003
23	Low-grade malignant eccrine spiradenoma with systemic metastases. (12775989)	Leonard N.... McNamara P.	2003
24	Malignant eccrine spiradenoma. (11958666)	Mirza I.... Sieber S.C.	2002
25	Malignant eccrine spiradenoma: a case report and review of the literature. (11231249)	Ishikawa M.... Yamamoto A.	2001
26	Malignant spiradenoma: report of two cases and literature review. (11174426)	FernA!ndez-AceA+ero M.J.... Requena L.	2001
27	Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review. (10535577)	Shapiro M.... Elenitsas R.	1999
28	Giant vascular eccrine spiradenoma. (9556114)	Senol M.... Ciralik H.	1998
29	Eccrine spiradenoma mimicking adenoid cystic carcinoma on fine needle aspiration. A case report. (9167714)	Kolda T.F.... Schwartz M.R.	1997
30	Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. (9129700)	Meybehm M.... Fischer H.P.	1997
31	Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. (8639057)	Saboorian M.H.... Albores-Saavedra J.	1996
32	Cutaneous adnexal carcinoma arising within a solitary cylindroma-spiradenoma. (8721596)	Biernat W.... Biernat S.	1996
33	Dermal cylindroma and eccrine spiradenoma. (8936072)	Lee M.W.... Kelly J.W.	1996
34	Eccrine spiradenoma of the hand clinically mimicking a lipoma. (8856552)	Al-Qattan M.M.	1996
35	Malignant eccrine spiradenoma with smooth muscle cell differentiation: histological and immunohistochemical study. (8970199)	Itoh T.... Tokunaga M.	1996
36	Zosteriform network of spiradenoma. (20948035)	Criton S.... Aravindan K.P.	1996
37	Immunohistochemical analysis of cytokeratin expression in eccrine spiradenoma: similarities to the transitional portions between secretory segments and coiled ducts of eccrine glands. (7532000)	Watanabe S.... Takahashi H.	1994
38	An uncommon breast tumour: the malignant eccrine spiradenoma. A case report. (8140844)	Thomas B.... Vanvuchelen J.	1993
39	Spiradenomas in Brooke-Spiegler syndrome. (7684205)	Weyers W.... Schill W.B.	1993
40	Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach. (1322262)	Bosch M.M.... Boon M.E.	1992
41	Malignant transformation in multiple eccrine spiradenoma]. (1317754)	Husek K.... SamohA1l J.	1992
42	Non-epithelial cellular components in eccrine spiradenoma: a histological and immunohistochemical study of 20 cases. (1849119)	l-Nafussi A.... Rahilly M.	1991
43	Fine needle aspiration cytology of malignant spiradenoma arising in congenital eccrine spiradenoma. (2157326)	Varsa E.W.... Jordan S.W.	1990
44	Multiple familial eccrine spiradenoma with cylindroma. (1967884)	Wright S.... Ryan J.	1990
45	Eccrine spiradenoma of eyelid: case report. (3017404)	Ahluwalia B.K.... Mehtani V.G.	1986
46	Sweat gland carcinoma of the hand: two cases of malignant eccrine spiradenoma. (6096437)	Yaremchuk M.J.... Wilgis E.F.	1984
47	Eccrine spiradenoma and dermal cylindroma. (6302142)	Gerber J.E.... Descalzi M.E.	1983
48	Spiradenoma. Histochemical and electron microscopic study. (4358394)	Castro C.... Winkelmann R.K.	1974
49	Eccrine spiradenoma. (4168808)	Baes H.	1967
50	Histochemistry of hidradenoma and eccrine spiradenoma. (4292174)	Winkelmann R.K.... Wolff K.	1967

Genes related to Spiradenoma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Spiradenoma:

(show all 11)

id	Symbol	Description	Score	Implication
1	CYLD	cylindromatosis (turban tumor syndrome)	20.87	GeneCards inferred : Publications, Disorders (show sections)
2	KRT14	keratin 14	19.05	GeneCards inferred : Publications, Disorders (show sections)
3	ACTC1	actin, alpha, cardiac muscle 1	17.24	GeneCards inferred : Publications, Disorders (show sections)
4	DKK2	dickkopf WNT signaling pathway inhibitor 2	15.42	GeneCards inferred : Disorders (show sections)
5	TP53	tumor protein p53	13.60	GeneCards inferred : Publications, Disorders (show sections)
6	CLEC2A	C-type lectin domain family 2, member A	11.78	GeneCards inferred : Disorders (show sections)
7	S100A1	S100 calcium binding protein A1	9.96	GeneCards inferred : Publications, Disorders (show sections)
8	KRT15	keratin 15	8.15	GeneCards inferred : Disorders (show sections)
9	SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	6.33	GeneCards inferred : Disorders (show sections)
10	KRT7	keratin 7	4.51	GeneCards inferred : Publications, Disorders (show sections)
11	DNTT	DNA nucleotidylexotransferase	2.69	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Spiradenoma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	10	10	11
2	LSBio	-	-	11

Genetic Variations for Spiradenoma

Expression for genes affiliated with Spiradenoma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

Compounds for genes affiliated with Spiradenoma

Sources:
⁴⁴Novoseek, ⁵⁹Tocris Bioscience, ²⁸IUPHAR, ¹¹DrugBank, ²⁴HMDB
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Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 14)

id	Compound	Score	Top Affiliating Genes
1	hpvs⁴⁴	9.9	KRT14, TP53
2	actomyosin⁴⁴	9.7	ACTC1, S100A1
3	calcipotriol⁴⁴ ⁵⁹ ²⁸ ¹¹	12.7	KRT15, KRT14
4	2-methoxyethanol⁴⁴	9.6	ACTC1, KRT14, S100A1
5	reticulin⁴⁴	9.4	ACTC1, KRT7
6	2-chlorodeoxyadenosine⁴⁴	9.3	TP53, DNTT
7	b 723⁴⁴	9.1	S100A1, KRT7, ACTC1
8	retinoid⁴⁴	8.9	KRT14, KRT7, TP53
9	mucicarmine⁴⁴	8.9	ACTC1, KRT7, KRT14, S100A1
10	hematoxylin⁴⁴	8.8	S100A1, KRT14, KRT7, ACTC1
11	iron⁴⁴ ²⁴	9.7	ACTC1, KRT7, KRT14, S100A1
12	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	12.4	S100A1, KRT14, KRT7, ACTC1, TP53
13	paraffin⁴⁴	7.9	S100A1, DNTT, KRT14, KRT7, ACTC1, TP53
14	retinoic acid⁴⁴ ²⁴	8.4	S100A1, DNTT, KRT14, KRT7, KRT15, ACTC1