MCID: SPR013
MIFTS: 47

Spiradenoma malady

Rare diseases, Eye diseases, Skin diseases, Ear diseases categories

Aliases & Classifications for Spiradenoma

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Spiradenoma, Aliases & Descriptions:

Name: Spiradenoma 9 11
Eccrine Spiradenoma 9 41 60
Benign Eccrine Spiradenoma 9 41
Eye Diseases 43 32
 
Eccrine Spiradenoma of Skin 9
Eccrine Spiradenoma, Benign 41
Disorder of Eye 60
Es 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Skin diseases, Ear diseases


External Ids:

Disease Ontology9 DOID:5444
SNOMED-CT55 403938001, 4977000
NCIt38 C4170

Summaries for Spiradenoma

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MedlinePlus:32 Some eye problems are minor and don't last long. but some can lead to a permanent loss of vision. common eye problems include refractive errors cataracts - clouded lenses glaucoma - a disorder caused by damage to the optic nerve retinal disorders - problems with the nerve layer at the back of the eye macular degeneration - a disease that destroys sharp, central vision diabetic eye problems conjunctivitis - an infection also known as pinkeye your best defense is to have regular checkups, because eye diseases do not always have symptoms. early detection and treatment could prevent vision loss. see an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes of light. other symptoms that need quick attention are pain, double vision, fluid coming from the eye, and inflammation. nih: national eye institute

MalaCards based summary: Spiradenoma, also known as eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)), and among its related pathways are Glucocorticoid receptor regulatory network and Cytoskeleton remodeling Keratin filaments. The drugs prednisone and prednisone pwdr and the compounds hpvs and reticulin have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and breast, and related mouse phenotypes are cellular and normal.

Wikipedia:63 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Related Diseases for Spiradenoma

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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1053)
idRelated DiseaseScoreTop Affiliating Genes
1brooke-spiegler syndrome31.4CYLD
2sarcoma30.5S100A1, ACTC1, TP53
3syringoma30.4KRT14, S100A1
4glomus tumor30.3ACTC1, S100A1
5ewing sarcoma30.1S100A1, DNTT
6teratoma30.0KRT7, ACTC1
7breast cancer30.0TP53, KRT14
8basal cell carcinoma29.6KRT7, KRT15, ACTC1, TP53
9psoriasis29.4KRT15, KRT14, S100A1
10adenocarcinoma29.3TP53, ACTC1, KRT14, KRT7
11adenoma29.1TP53, ACTC1, S100A1, KRT14, KRT7
12melanoma29.0TP53, ACTC1, S100A1, KRT14
13eye disease11.1
14fish-eye disease10.7
15malignant spiradenoma10.6
16meningioma, familial10.5S100A1
17pseudomyxoma peritonei10.4KRT7
18aland island eye disease10.4
19cataract10.4
20syringocystadenoma papilliferum10.4KRT15, CLEC2A
21breast malignant eccrine spiradenoma10.3
22neuroectodermal tumor10.3
23blindness10.3
24benign eccrine breast spiradenoma10.3
25adnexal spiradenoma/cylindroma of a sweat gland10.3
26alopecia10.3KRT15, CLEC2A
27herpes simplex10.3
28nephrogenic adenoma10.3KRT7, S100A1
29status epilepticus10.3
30thyroiditis10.3
31oxyphilic adenoma10.3KRT7, S100A1
32keratitis10.3
33renal oncocytoma10.3KRT7, S100A1
34strabismus10.3
35cutaneous fibrous histiocytoma10.2S100A1, ACTC1
36adenoiditis10.2
37dermatofibrosarcoma protuberans10.2S100A1, ACTC1
38neuronitis10.2
39hemangiopericytoma10.2S100A1, ACTC1
40angiomyolipoma10.2ACTC1, S100A1
41fibroma10.2ACTC1, S100A1
42fibromatosis10.2ACTC1, S100A1
43smooth muscle tumor10.2ACTC1, S100A1
44renal cell carcinoma10.2KRT7, TP53
45malignant peripheral nerve sheath tumor10.2ACTC1, S100A1
46neurofibroma10.2ACTC1, S100A1
47refractive error10.2
48malignant fibroxanthoma10.2ACTC1, S100A1
49renal clear cell carcinoma10.2KRT7, S100A1
50urinary schistosomiasis10.2

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to spiradenoma

Symptoms for Spiradenoma

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Drugs & Therapeutics for Spiradenoma

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Drug clinical trials:

Search ClinicalTrials for Spiradenoma

Search NIH Clinical Center for Spiradenoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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MalaCards organs/tissues related to Spiradenoma:

31
Eye, Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

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MGI Mouse Phenotypes related to Spiradenoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.5TP53, ACTC1, KRT14, KRT7, CYLD
2MP:00028738.0S100A1, DNTT, ACTC1, TP53, CYLD

Publications for Spiradenoma

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Articles related to Spiradenoma:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
A serpentine inside eccrine spiradenoma: a new trichoscopic sign. (25878450)
2015
2
Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. (25354097)
2014
3
Differential diagnosis of eccrine spiradenoma: A case report. (25187803)
2014
4
Eccrine spiradenoma in knee. (25284865)
2014
5
Cystic eccrine spiradenoma of the finger mimicking a ganglion. (25289292)
2014
6
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. (24118397)
2013
7
Dermatoscopic pattern of a spiradenoma. (23785623)
2012
8
Malignant eccrine spiradenoma: a meta-analysis of reported cases. (20851376)
2011
9
Giant vascular eccrine spiradenoma. (22148049)
2011
10
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. (21430945)
2011
11
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. (19222500)
2010
12
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)
2010
13
Spiradenoma with marked adenomyoepitheliomatous features. (20859082)
2010
14
Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. (19684510)
2009
15
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
16
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. (20101314)
2009
17
Multiple nodules of the head--clinicopathologic challenge. Multiple eccrine spiradenoma. (19261009)
2009
18
Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)
2009
19
Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. (19454360)
2009
20
Recurrent atypical eccrine spiradenoma of the forehead. (19181014)
2008
21
MRI appearance of multiple eccrine spiradenoma. (17267467)
2007
22
Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)
2007
23
Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. (16479087)
2006
24
Congenital blaschkoid eccrine spiradenoma on the face. (15757814)
2005
25
Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. (15869542)
2005
26
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
27
Spiradenocarcinoma of the breast arising in a long-standing spiradenoma. (15185264)
2004
28
Eccrine spiradenoma: an unusual presentation with otalgia. (14990930)
2004
29
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. (14989745)
2004
30
Papular lesion of the proximal nail fold. Eccrine spiradenoma. (15313820)
2004
31
Familial eccrine spiradenoma: a case report and review of the literature. (12656824)
2003
32
Multiple eccrine spiradenoma in zosteriform distribution. (12960891)
2003
33
Malignant eccrine spiradenoma occurring on a traumatized area. (12087301)
2002
34
Extensive naevoid eccrine spiradenoma. (10215788)
1999
35
Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review. (10535577)
1999
36
Eccrine spiradenoma mimicking adenoid cystic carcinoma on fine needle aspiration. A case report. (9167714)
1997
37
Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. (8639057)
1996
38
Cutaneous adnexal carcinoma arising within a solitary cylindroma-spiradenoma. (8721596)
1996
39
Eccrine spiradenoma, not poroma. (8634818)
1996
40
An unusual, recurring breast tumor with features of eccrine spiradenoma: a case report. (8929479)
1996
41
Over-expression of p53 protein as an indicator of the malignant transformation in spiradenoma. (7657312)
1995
42
Stump the experts. Eccrine spiradenoma. (8388416)
1993
43
Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach. (1322262)
1992
44
Congenital spiradenoma. (2851273)
1988
45
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
46
Eccrine spiradenoma: clinical and pathologic study of 49 tumors. (6313776)
1983
47
An unusual tumor of the female breast: combined eccrine and apocrine spiradenoma. (6310473)
1983
48
Carcinoma arising in eccrine spiradenoma. (445374)
1979
49
Proceedings: Dermal eccrine cylindroma, epithelioma adenoides cysticum of Brooke, and ecrine spiradenoma. (4375438)
1974
50
Eccrine spiradenoma. Histochemical and electron microscopic studies. (4286974)
1966

Variations for Spiradenoma

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Expression for genes affiliated with Spiradenoma

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Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

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Pathways related to Spiradenoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KRT14, TP53
29.6KRT7, KRT14

Compounds for genes affiliated with Spiradenoma

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Compounds related to Spiradenoma according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1hpvs4310.0TP53, KRT14
2reticulin439.9KRT7, ACTC1
3actomyosin439.8ACTC1, S100A1
4methanol43 2410.6ACTC1, KRT7
52-chlorodeoxyadenosine439.6DNTT, TP53
62-methoxyethanol439.6ACTC1, S100A1, KRT14
7dutp439.6DNTT, TP53
8calcipotriol43 59 28 1212.5KRT14, KRT15
9carboplatin43 49 1211.4DNTT, TP53
10retinoid439.4KRT14, TP53, KRT7
11b 723439.4ACTC1, KRT7, S100A1
12fludarabine43 49 1211.3TP53, DNTT
13butyrate439.3KRT14, DNTT, TP53
14glycogen43 2410.2KRT7, S100A1, ACTC1
15mucicarmine439.1S100A1, KRT14, KRT7, ACTC1
16hematoxylin439.0KRT7, ACTC1, S100A1, KRT14
17iron43 2410.0ACTC1, KRT14, KRT7, S100A1
18cisplatin43 49 59 1211.8DNTT, TP53, KRT14
19progesterone43 28 59 24 1212.6TP53, ACTC1, S100A1, KRT14, KRT7
20estrogen438.6KRT14, KRT7, TP53, ACTC1, S100A1
21tyrosine438.1S100A1, KRT7, KRT14, KRT15, ACTC1
22paraffin438.0KRT14, KRT7, S100A1, DNTT, TP53, ACTC1
23retinoic acid43 248.2ACTC1, TP53, DNTT, S100A1, KRT14, KRT15

GO Terms for genes affiliated with Spiradenoma

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Cellular components related to Spiradenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.6KRT7, KRT14
2intermediate filamentGO:00058828.5KRT7, KRT15, KRT14

Biological processes related to Spiradenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:00085449.3KRT15, KRT14

Molecular functions related to Spiradenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.3KRT15, KRT14
2protein bindingGO:00055156.7KRT7, KRT15, KRT14, S100A1, CLEC2A, TP53

Products for genes affiliated with Spiradenoma

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Sources for Spiradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet