ES
MCID: SPR013
MIFTS: 36

Spiradenoma (ES) malady

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Spiradenoma

Aliases & Descriptions for Spiradenoma:

Name: Spiradenoma 12 14
Eccrine Spiradenoma 12 50 69
Benign Eccrine Spiradenoma 12 50
Eccrine Spiradenoma of Skin 12
Eccrine Spiradenoma, Benign 50
Es 50

Classifications:



External Ids:

Disease Ontology 12 DOID:5444
NCIt 47 C4170
SNOMED-CT 64 403938001 4977000
UMLS 69 C0334347

Summaries for Spiradenoma

MalaCards based summary : Spiradenoma, also known as eccrine spiradenoma, is related to intestinal obstruction and malignant spiradenoma. An important gene associated with Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. The drugs Erbitux and Evista have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells.

Wikipedia : 71 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Related Diseases for Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
id Related Disease Score Top Affiliating Genes
1 intestinal obstruction 29.4 ACTC1 VIM
2 malignant spiradenoma 12.3
3 benign eccrine breast spiradenoma 11.8
4 breast malignant eccrine spiradenoma 11.8
5 adnexal spiradenoma/cylindroma of a sweat gland 11.8
6 brooke-spiegler syndrome 11.5
7 ewing sarcoma 11.2
8 cylindromatosis, familial 11.0
9 diabetic mastopathy 10.9
10 dermis tumor 10.3 CYLD TP53
11 bone deterioration disease 10.2 S100B TP53
12 central nervous system mature teratoma 10.2 S100B TP53
13 clear cell cystadenofibroma 10.2 CYLD KRT14
14 adult brainstem gliosarcoma 10.2 TP53 VIM
15 lupus - neurological sequelae 10.2 S100B VIM
16 benign schwannoma 10.2 S100B VIM
17 spastic ataxia 5 10.2 TP53 VIM
18 jejunal neuroendocrine tumor 10.2 S100B VIM
19 vascular myelopathy 10.2 S100B TP53
20 cavernous sinus meningioma 10.2 S100B VIM
21 ossifying fibromyxoid tumor 10.2 TP53 VIM
22 heavy chain disease 10.2 CYLD KRT14
23 secondary corneal edema 10.2 KRT14 TP53
24 pericardium leiomyoma 10.2 ACTC1 TP53
25 thymus squamous cell carcinoma 10.2 KRT14 TP53
26 stomach diverticulosis 10.2 S100B VIM
27 skin glomus tumor 10.2 S100B VIM
28 aml with myelodysplasia-related features 10.1 KRT14 VIM
29 acute generalized exanthematous pustulosis 10.1 ACTC1 S100B
30 inner ear cancer 10.1 S100B TP53
31 paraphimosis 10.1 ACTC1 TP53
32 chiasmal syndrome 10.1 ACTC1 S100B
33 onychocytic matricoma 10.1 S100B VIM
34 13q12.3 microdeletion syndrome 10.1 ACTC1 VIM
35 multicentric papillary thyroid carcinoma 10.1 KRT14 TP53
36 house allergic alveolitis 10.1 ACTC1 TP53
37 onychodystrophy-anonychia 10.1 KRT14 VIM
38 lymphomatoid papulosis 10.1 ACTC1 VIM
39 chest wall parachordoma 10.1 ACTC1 VIM
40 isolated anterior cervical hypertrichosis 10.1 ACTC1 VIM
41 osteomyelitis 10.1 ACTC1 VIM
42 congenital myasthenic syndrome 10.1 ACTC1 VIM
43 malignant dermis tumor 10.1 ACTC1 VIM
44 urethral cancer 10.1 ACTC1 VIM
45 vulva adenocarcinoma 10.1 KRT14 TP53
46 plasmodium ovale malaria 10.1 ACTC1 TP53
47 biemond syndrome 10.1 ACTC1 VIM
48 male urethral cancer 10.1 ACTC1 VIM
49 estrogen-receptor positive breast cancer 10.1 KRT14 TP53
50 t-cell childhood lymphoblastic lymphoma 10.1 ACTC1 VIM

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to Spiradenoma

Symptoms & Phenotypes for Spiradenoma

Drugs & Therapeutics for Spiradenoma

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Erbitux 17 46 CETUXIMAB Imclone, Bristol-Myers Squibb Approved February 2004
2
Evista 17 46 RALOXIFENE HYDROCHLORIDE Eli Lilly Approved September 2007
3
Istodax 17 46 ROMIDEPSIN Gloucester Pharmaceuticals Approved November 2009
4
Treanda 17 46 BENDAMUSTINE HYDROCHLORIDE Cephalon Approved October 2008

Search Clinical Trials , NIH Clinical Center for Spiradenoma

Genetic Tests for Spiradenoma

Anatomical Context for Spiradenoma

MalaCards organs/tissues related to Spiradenoma:

39
Skin, Breast, T Cells, B Cells, Testes, Endothelial, Bone

Publications for Spiradenoma

Articles related to Spiradenoma:

(show top 50) (show all 164)
id Title Authors Year
1
FDG PET/CT in Malignant Eccrine Spiradenoma. ( 28005641 )
2017
2
Distinctive immunostaining of claudin-4 in spiradenomas. ( 26616722 )
2016
3
Giant vascular eccrine spiradenoma of the leg: MR imaging findings. ( 27397887 )
2016
4
Spiradenoma causing longitudinal splitting of the nail. ( 27663150 )
2016
5
A rare case of eccrine spiradenoma-treatment and management. ( 27069311 )
2016
6
Eccrine Spiradenoma Arising from the Breast Skin. ( 26236527 )
2015
7
Sonographic and sonoelastographic findings of a rarely seen soft tissue tumor: eccrine spiradenoma. ( 26576987 )
2015
8
A serpentine inside eccrine spiradenoma: a new trichoscopic sign. ( 25878450 )
2015
9
Malignant eccrine spiradenoma of the external ear. ( 26211868 )
2015
10
Trichoepithelioma and spiradenoma collision tumor. ( 25942028 )
2015
11
Giant eccrine spiradenoma mimicking a malignant tumor. ( 25566913 )
2015
12
Multiple Segmental Eccrine Spiradenoma with a Zosteriform Pattern: A Case Report and Literature Review. ( 26273161 )
2015
13
Spiradenocarcinoma in Preexisting Spiradenoma With a Large In Situ Adenocarcinoma Component. ( 25830720 )
2015
14
Malignant eccrine breast spiradenoma. A case report and literature review. ( 26318134 )
2015
15
Zosteriform spiradenoma with spiradenocarcinoma: A rare entity. ( 26904446 )
2015
16
Malignant Eccrine Spiradenoma of the Face. ( 26167988 )
2015
17
Inexplicable Co- Existence of Eccrine Spiradenoma and Lichen Planus in an old Case of Basal Cell Carcinoma. ( 25737995 )
2015
18
Giant Vascular Eccrine Spiradenoma. ( 26365030 )
2015
19
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. ( 26563774 )
2015
20
Tubular Spitz Naevus Mimicking Eccrine Spiradenoma. ( 23756597 )
2014
21
Case of recurrence of spiradenoma in palpebral conjunctiva. ( 24969313 )
2014
22
Eccrine spiradenoma in knee. ( 25284865 )
2014
23
Fine needle aspiration cytology of eccrine spiradenoma of back: report of a rare case. ( 25328342 )
2014
24
Differential diagnosis of eccrine spiradenoma: A case report. ( 25187803 )
2014
25
Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. ( 25354097 )
2014
26
Cystic eccrine spiradenoma of the finger mimicking a ganglion. ( 25289292 )
2014
27
A malignant eccrine spiradenoma of the scalp. ( 24842352 )
2014
28
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. ( 24118397 )
2013
29
Immunohistochemical characterization of non-epithelial cells in spiradenoma. ( 24580131 )
2013
30
Giant vascular eccrine spiradenoma mimicking calcifying epithelioma. ( 23961898 )
2013
31
Neonatal spiradenoma. ( 22747799 )
2013
32
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma and eccrine spiradenoma. ( 24261740 )
2013
33
Dermatoscopic pattern of a spiradenoma. ( 23785623 )
2012
34
Malignant spiradenoma/cylindroma of the vulva. ( 23147883 )
2012
35
Painful eccrine spiradenoma containing nerve fibers: a case report. ( 22777362 )
2012
36
Carcinosarcoma ex eccrine spiradenoma of the vulva: report of the first case. ( 21464722 )
2011
37
Differential considerations of skin tumours with florid vascularisation: report of a solitary giant vascular eccrine spiradenoma. ( 22689604 )
2011
38
Giant vascular eccrine spiradenoma. ( 22148049 )
2011
39
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. ( 21430945 )
2011
40
Alteration of the I^-catenin pathway in spiradenoma. ( 21518380 )
2011
41
Malignant eccrine spiradenoma: a meta-analysis of reported cases. ( 20851376 )
2011
42
A rare case of giant malignant eccrine spiradenoma. ( 21342314 )
2011
43
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression. ( 21598248 )
2011
44
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. ( 20483125 )
2010
45
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. ( 19222500 )
2010
46
A case of eccrine spiradenoma in a patient with neurofibromatosis. ( 20548911 )
2010
47
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. ( 20075707 )
2010
48
Spiradenoma with marked adenomyoepitheliomatous features. ( 20859082 )
2010
49
Malignant eccrine spiradenoma: a new case report. ( 19614990 )
2010
50
A case of giant vascular eccrine spiradenoma with unusual clinical features. ( 19323658 )
2009

Variations for Spiradenoma

Expression for Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for Spiradenoma

Pathways related to Spiradenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 ACTC1 MUC1 VIM
2 10.86 MUC1 TP53 VIM

GO Terms for Spiradenoma

Cellular components related to Spiradenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 ACTC1 CYLD KRT14 MUC1 S100B TP53

Biological processes related to Spiradenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.33 ACTC1 TP53 VIM
2 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.26 MUC1 TP53
3 muscle filament sliding GO:0030049 8.96 ACTC1 VIM
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.62 MUC1 TP53

Molecular functions related to Spiradenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratin filament binding GO:1990254 8.62 KRT14 VIM

Sources for Spiradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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