Spiradenoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Spiradenoma

Sources:
³³MedlinePlus, ⁶⁴Wikipedia, ³²MalaCards
See all sources

MedlinePlus:³³ Some eye problems are minor and don't last long. but some can lead to a permanent loss of vision. common eye problems include refractive errors cataracts - clouded lenses glaucoma - a disorder caused by damage to the optic nerve retinal disorders - problems with the nerve layer at the back of the eye macular degeneration - a disease that destroys sharp, central vision diabetic eye problems conjunctivitis - an infection also known as pinkeye your best defense is to have regular checkups, because eye diseases do not always have symptoms. early detection and treatment could prevent vision loss. see an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes of light. other symptoms that need quick attention are pain, double vision, fluid coming from the eye, and inflammation. nih: national eye institute

MalaCards based summary: Spiradenoma, also known as benign eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)), and among its related pathways are Glucocorticoid receptor regulatory network and Cytoskeleton remodeling Keratin filaments. The drugs prednisone and prednisone pwdr and the compounds hpvs and reticulin have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and breast, and related mouse phenotypes are cellular and normal.

Wikipedia:⁶⁴ Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Aliases & Classifications for Spiradenoma

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁴⁴Novoseek, ³³MedlinePlus, ⁶¹UMLS, ⁵⁶SNOMED-CT, ³⁹NCIt
See all sources

Spiradenoma, Aliases & Descriptions:

Name: Spiradenoma ⁹ ¹¹

Benign Eccrine Spiradenoma ⁹ ⁴² ⁶¹

Eccrine Spiradenoma ⁹ ⁴² ⁶¹

Eccrine Spiradenoma of Skin ⁹ ⁶¹

Eye Diseases ⁴⁴ ³³

Eye Disease ¹¹ ⁶¹

Eccrine Spiradenoma, Benign ⁴²

Disorder of Eye ⁶¹

Es ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Eye diseases, Skin diseases, Ear diseases

External Ids:

Disease Ontology⁹ DOID:5444

SNOMED-CT⁵⁶ 403938001, 4977000

NCIt³⁹ C4170

UMLS⁶¹ C1332494, C0334347

Related Diseases for Spiradenoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 1341)

id	Related Disease	Score	Top Affiliating Genes
1	brooke-spiegler syndrome	31.5	CYLD
2	sarcoma	30.5	S100A1, ACTC1, TP53
3	syringoma	30.4	KRT14, S100A1
4	teratoma	30.0	KRT7, ACTC1
5	peripheral primitive neuroectodermal tumor	29.9	DNTT, S100A1
6	psoriasis	29.4	S100A1, KRT14, KRT15
7	adenoma	29.2	KRT7, S100A1, ACTC1, TP53, KRT14
8	melanoma	29.0	S100A1, KRT14, ACTC1, TP53
9	breast cancer	28.8	KRT14, ACTC1, TP53, KRT15, KRT7, S100A1
10	eye disease	11.1
11	fish-eye disease	10.7
12	malignant spiradenoma	10.6
13	meningioma	10.5	S100A1
14	pseudomyxoma peritonei	10.4	KRT7
15	aland island eye disease	10.4
16	age related macular degeneration	10.4
17	syringocystadenoma papilliferum	10.4	CLEC2A, KRT15
18	cataract	10.3
19	neuroectodermal tumor	10.3
20	blindness	10.3
21	breast malignant eccrine spiradenoma	10.3
22	alopecia	10.3	CLEC2A, KRT15
23	herpes simplex	10.3
24	keratitis	10.3
25	nephrogenic adenoma	10.3	S100A1, KRT7
26	oxyphilic adenoma	10.3	S100A1, KRT7
27	renal oncocytoma	10.3	S100A1, KRT7
28	status epilepticus	10.3
29	thyroiditis	10.3
30	strabismus	10.3
31	cutaneous fibrous histiocytoma	10.2	ACTC1, S100A1
32	benign eccrine breast spiradenoma	10.2
33	adenoiditis	10.2
34	adnexal spiradenoma/cylindroma of a sweat gland	10.2
35	dermatofibrosarcoma protuberans	10.2	ACTC1, S100A1
36	hemangiopericytoma	10.2	S100A1, ACTC1
37	angiomyolipoma	10.2	S100A1, ACTC1
38	fibroma	10.2	ACTC1, S100A1
39	paraganglioma	10.2	ACTC1, S100A1
40	neuronitis	10.2
41	fibromatosis	10.2	S100A1, ACTC1
42	smooth muscle tumor	10.2	S100A1, ACTC1
43	malignant peripheral nerve sheath tumor	10.2	ACTC1, S100A1
44	refractive error	10.2
45	neurofibroma	10.2	S100A1, ACTC1
46	malignant fibroxanthoma	10.2	ACTC1, S100A1
47	renal clear cell carcinoma	10.2	KRT7, S100A1
48	spindle cell sarcoma	10.2	ACTC1, KRT7
49	gastric cancer	10.2
50	malignant mesothelioma	10.2	KRT7, S100A1

Graphical network of the top 20 diseases related to Spiradenoma:

Symptoms for Spiradenoma

Drugs & Therapeutics for Spiradenoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Spiradenoma

Search NIH Clinical Center for Spiradenoma

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

prednisone

prednisone pwdr

Genetic Tests for Spiradenoma

Anatomical Context for Spiradenoma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Spiradenoma:

³²

Eye, Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Spiradenoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	8.5	TP53, ACTC1, KRT14, KRT7, CYLD
2	normal phenotype	MP:0002873	8.0	S100A1, DNTT, ACTC1, TP53, CYLD

Publications for Spiradenoma

Sources:
⁵¹PubMed
See all sources

Articles related to Spiradenoma:

(show top 50) (show all 145)

id	Title	Authors	Year
1	Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. (25354097)	Sellheyer K.	2014
2	Differential diagnosis of eccrine spiradenoma: A case report. (25187803)	Zheng Y.... Xiao S.	2014
3	Eccrine spiradenoma in knee. (25284865)	Sharma A.... Chattopadhya S.	2014
4	Cystic eccrine spiradenoma of the finger mimicking a ganglion. (25289292)	Jaber K.F.... Yoon A.S.	2014
5	Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. (24118397)	Rahim R.R.... Langtry J.A.	2013
6	Dermatoscopic pattern of a spiradenoma. (23785623)	Tschandl P.	2012
7	Malignant eccrine spiradenoma: a meta-analysis of reported cases. (20851376)	Andreoli M.T.... Itani K.M.	2011
8	Giant vascular eccrine spiradenoma. (22148049)	Kim M.H.... Cho S.H.	2011
9	Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. (21430945)	Lee H.H.... Park H.K.	2011
10	Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. (19222500)	Tanese K.... Ishiko A.	2010
11	Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)	Kazakov D.V.... Michal M.	2010
12	Spiradenoma with marked adenomyoepitheliomatous features. (20859082)	Kacerovska D.... Michal M.	2010
13	Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. (20483125)	Jariwala A.... McLeod G.	2010
14	Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. (19684510)	Jukic D.M.... Davie J.R.	2009
15	Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)	Nath A.K.... Thappa D.M.	2009
16	Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. (20101314)	BerAsin S.... SA1ren D.	2009
17	Multiple nodules of the head--clinicopathologic challenge. Multiple eccrine spiradenoma. (19261009)	Lobo I.... Selores M.	2009
18	Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)	Levidou G.... Androulaki A.	2009
19	Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. (19454360)	Kazakov D.V.... Skalova A.	2009
20	Recurrent atypical eccrine spiradenoma of the forehead. (19181014)	Delfino S.... Persichetti P.	2008
21	MRI appearance of multiple eccrine spiradenoma. (17267467)	Han Y.D.... Zhang C.H.	2007
22	Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)	Kurokawa I.... Tsubura A.	2007
23	Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. (16479087)	Ko J.Y.... Park C.K.	2006
24	Congenital blaschkoid eccrine spiradenoma on the face. (15757814)	Ekmekci T.R.... Sakiz D.	2005
25	Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. (15869542)	Bumgardner A.C.... Schwartz M.R.	2005
26	Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)	Uede K.... Furukawa F.	2004
27	Spiradenocarcinoma of the breast arising in a long-standing spiradenoma. (15185264)	Ribeiro-Silva A.... Ponton F.	2004
28	Eccrine spiradenoma: an unusual presentation with otalgia. (14990930)	Nadig S.K.... Rao T.J.	2004
29	Malignant eccrine spiradenoma: a case report with pulmonary metastasis. (14989745)	Chou S.C.... Tseng H.H.	2004
30	Papular lesion of the proximal nail fold. Eccrine spiradenoma. (15313820)	Leach B.C.... Graham B.S.	2004
31	Familial eccrine spiradenoma: a case report and review of the literature. (12656824)	Ter Poorten M.C.... Cook J.	2003
32	Multiple eccrine spiradenoma in zosteriform distribution. (12960891)	Altinyazar H.C.... BabucAsu O.	2003
33	Malignant eccrine spiradenoma occurring on a traumatized area. (12087301)	Arslan E.... Cin I.	2002
34	Extensive naevoid eccrine spiradenoma. (10215788)	Bedlow A.J.... Kurwa A.	1999
35	Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review. (10535577)	Shapiro M.... Elenitsas R.	1999
36	Eccrine spiradenoma mimicking adenoid cystic carcinoma on fine needle aspiration. A case report. (9167714)	Kolda T.F.... Schwartz M.R.	1997
37	Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. (8639057)	Saboorian M.H.... Albores-Saavedra J.	1996
38	Cutaneous adnexal carcinoma arising within a solitary cylindroma-spiradenoma. (8721596)	Biernat W.... Biernat S.	1996
39	Eccrine spiradenoma, not poroma. (8634818)	Beckman B.	1996
40	An unusual, recurring breast tumor with features of eccrine spiradenoma: a case report. (8929479)	Panico L.... Pettinato G.	1996
41	Over-expression of p53 protein as an indicator of the malignant transformation in spiradenoma. (7657312)	Biernat W.... WoA_niak L.	1995
42	Stump the experts. Eccrine spiradenoma. (8388416)	Thorisdottir K.... McGillis S.T.	1993
43	Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach. (1322262)	Bosch M.M.... Boon M.E.	1992
44	Congenital spiradenoma. (2851273)	Schmoeckel C.... Burg G.	1988
45	Sweat gland carcinoma ex eccrine spiradenoma. (2847574)	Wick M.R.... Pittelkow M.R.	1987
46	Eccrine spiradenoma: clinical and pathologic study of 49 tumors. (6313776)	Mambo N.C.	1983
47	An unusual tumor of the female breast: combined eccrine and apocrine spiradenoma. (6310473)	Zawirska B.... Markuszewska-Bednarz J.	1983
48	Carcinoma arising in eccrine spiradenoma. (445374)	Evans H.L.... Winkelmann R.K.	1979
49	Proceedings: Dermal eccrine cylindroma, epithelioma adenoides cysticum of Brooke, and ecrine spiradenoma. (4375438)	Gottschalk H.R.	1974
50	Eccrine spiradenoma. Histochemical and electron microscopic studies. (4286974)	Hashimoto K.... LEVER W.F.	1966

Genes related to Spiradenoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Spiradenoma:

- Elite gene

id	Symbol	Description	Score	Implication
1	CYLD	cylindromatosis (turban tumor syndrome)	21.07	GeneCards inferred via : Publications, Disorders (show sections)
2	ACTC1	actin, alpha, cardiac muscle 1	18.85	GeneCards inferred via : Publications (show sections)
3	KRT14	keratin 14	16.62	GeneCards inferred via : Publications (show sections)
4	TP53	tumor protein p53	14.40	GeneCards inferred via : Publications (show sections)
5	CLEC2A	C-type lectin domain family 2, member A	12.18	GeneCards inferred via : Disorders (show sections)
6	S100A1	S100 calcium binding protein A1	9.96	GeneCards inferred via : Publications (show sections)
7	DNTT	DNA nucleotidylexotransferase	7.74	GeneCards inferred via : Publications (show sections)
8	KRT15	keratin 15	5.51	GeneCards inferred via : Disorders (show sections)
9	KRT7	keratin 7	3.29	GeneCards inferred via : Publications (show sections)

Products for genes related to Spiradenoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	8	-	9	9
2	Novus Biologicals	7	8	9	-

Variations for Spiradenoma

Expression for genes affiliated with Spiradenoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

Sources:
⁴⁹PathCards, ³⁷NCBI BioSystems Database, ⁵⁹Thomson Reuters, ¹³EMD Millipore
See all sources

Pathways related to Spiradenoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Glucocorticoid receptor regulatory network³⁷	9.7	KRT14, TP53
2	Cytoskeleton remodeling Keratin filaments⁵⁹	9.6	KRT7, KRT14
3	Selected targets of p53¹³	9.2	KRT15, TP53

Compounds for genes affiliated with Spiradenoma

Sources:
⁴⁴Novoseek, ²⁵HMDB, ⁶⁰Tocris Bioscience, ²⁹IUPHAR, ¹²DrugBank, ⁵⁰PharmGKB
See all sources

Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 23)

id	Compound	Score	Top Affiliating Genes
1	hpvs⁴⁴	10.0	KRT14, TP53
2	reticulin⁴⁴	9.9	KRT7, ACTC1
3	actomyosin⁴⁴	9.8	S100A1, ACTC1
4	2-chlorodeoxyadenosine⁴⁴	9.6	DNTT, TP53
5	methanol⁴⁴ ²⁵	10.6	KRT7, ACTC1
6	2-methoxyethanol⁴⁴	9.6	KRT14, S100A1, ACTC1
7	dutp⁴⁴	9.6	DNTT, TP53
8	calcipotriol⁴⁴ ⁶⁰ ²⁹ ¹²	12.5	KRT15, KRT14
9	carboplatin⁴⁴ ⁵⁰ ¹²	11.4	DNTT, TP53
10	retinoid⁴⁴	9.4	TP53, KRT14, KRT7
11	b 723⁴⁴	9.4	ACTC1, S100A1, KRT7
12	fludarabine⁴⁴ ⁵⁰ ¹²	11.3	DNTT, TP53
13	butyrate⁴⁴	9.3	TP53, DNTT, KRT14
14	glycogen⁴⁴ ²⁵	10.2	ACTC1, S100A1, KRT7
15	mucicarmine⁴⁴	9.1	KRT7, KRT14, S100A1, ACTC1
16	hematoxylin⁴⁴	9.0	ACTC1, S100A1, KRT14, KRT7
17	iron⁴⁴ ²⁵	10.0	ACTC1, S100A1, KRT14, KRT7
18	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.8	TP53, DNTT, KRT14
19	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	12.6	TP53, ACTC1, S100A1, KRT14, KRT7
20	estrogen⁴⁴	8.6	KRT7, KRT14, S100A1, ACTC1, TP53
21	tyrosine⁴⁴	8.1	KRT7, KRT15, KRT14, S100A1, ACTC1
22	paraffin⁴⁴	8.0	TP53, ACTC1, DNTT, S100A1, KRT14, KRT7
23	retinoic acid⁴⁴ ²⁵	8.2	TP53, ACTC1, DNTT, S100A1, KRT14, KRT15