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MCID: SPR013

Spiradenoma (ES) malady
10 genes, 2 tissues, 331 related diseases, clinical trials.

Summaries for Spiradenoma

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Sources:
59Wikipedia, 29MalaCards
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Wikipedia:59 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

MalaCards: Spiradenoma, also known as eccrine spiradenoma, is related to prostate cancer and brooke-spiegler syndrome. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)). The compounds hpvs and 2-chlorodeoxyadenosine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, smooth muscle and skin.

Aliases & Classifications for Spiradenoma

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Sources:
8Disease Ontology, 10DISEASES, 39NIH Rare Diseases, 56UMLS, 52SNOMED-CT, 36NCIt
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Aliases & Descriptions:

spiradenoma 8 10
eccrine spiradenoma 8 39 56
benign eccrine spiradenoma 8 39
eccrine spiradenoma, benign 39
eccrine spiradenoma of skin 8
es 39



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Disease Ontology8 DOID:5444
SNOMED-CT52 4977000, 403938001
NCIt36 C4170

Related Diseases for Spiradenoma

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Sources:
16GeneCards, 17GeneDecks
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Disease types for spiradenoma family:

malignant spiradenoma

Diseases related to spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 331)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer31.4KRT7
2brooke-spiegler syndrome31.1CYLD
3breast cancer29.7KRT7, S100A1, KRT15, TP53, ACTC1, KRT14
4lung cancer29.0S100A1, KRT14, DNTT, TP53
5thymoma28.6DNTT
6sarcoma28.4S100A1, TP53, ACTC1
7melanoma28.3TP53, S100A1, ACTC1, KRT14
8squamous cell carcinoma28.3S100A1, KRT15, KRT14, KRT7, ACTC1, TP53
9hepatocellular carcinoma28.1KRT7, KRT14, TP53
10adenocarcinoma28.0ACTC1, KRT7, TP53, KRT14
11cholesteatoma27.4S100A1, KRT14
12meningioma26.9TP53, S100A1
13epidermolysis bullosa26.6KRT14
14epidermolysis bullosa simplex26.2KRT14
15psoriasis25.5KRT15, KRT14, S100A1
16leiomyosarcoma25.1TP53, S100A1, ACTC1
17basal cell carcinoma24.6KRT7, ACTC1, KRT15, TP53
18syringocystadenoma papilliferum13.6KRT15
19synovial sarcoma13.6KRT7
20cystadenoma13.5KRT7
21mixed cell type cancer13.5KRT7
22paraganglioma13.5S100A1
23thymic carcinoma13.5KRT7
24craniopharyngioma13.5KRT14
25nephroblastoma13.4TP53
26adrenocortical carcinoma13.4TP53
27alopecia13.3KRT15
28hidrocystoma13.3SGTA
29renal oncocytoma13.2S100A1, KRT7
30malignant mesothelioma13.2KRT7, S100A1
31syringoma13.1S100A1, KRT14
32angiomyolipoma13.1ACTC1, S100A1
33nephrogenic adenoma13.1KRT7, S100A1
34dermatofibrosarcoma protuberans13.1ACTC1, S100A1
35smooth muscle tumor13.1ACTC1, S100A1
36oxyphilic adenoma13.1KRT7, S100A1
37fibromatosis13.0ACTC1, S100A1
38leiomyoma13.0ACTC1, S100A1
39cutaneous fibrous histiocytoma13.0ACTC1, S100A1
40malignant fibroxanthoma13.0ACTC1, S100A1
41bowen syndrome13.0KRT14, KRT7
42spindle cell sarcoma13.0KRT7, ACTC1
43ossifying fibroma12.9ACTC1, S100A1
44gastrointestinal stromal tumor12.9S100A1, ACTC1
45angiosarcoma12.9KRT14, ACTC1
46teratoma12.9ACTC1, KRT7
47glomus tumor12.9S100A1, ACTC1
48breast fibroadenoma12.9KRT15, KRT14
49ductal carcinoma in situ12.9TP53, KRT14
50desmoid tumor12.9ACTC1

Graphical network of the top 20 diseases related to spiradenoma:



Diseases related to spiradenoma

Symptoms for Spiradenoma

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Drugs & Therapeutics for Spiradenoma

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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Sources:
29MalaCards
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MalaCards organs/tissues related to spiradenoma:

29
Smooth muscle, Skin

Animal Models for Spiradenoma or affiliated genes

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Sources:
26inGenious Targeting Laboratory
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Publications for Spiradenoma

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Sources:
47PubMed
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Articles related to spiradenoma:

idTitleAuthorsYearAffiliating Genes
1Expression of p53 and TP53 mutational analysis in mal ignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenoc ylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)Kazakov D.V.... Michal M.2010TP53
2Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the st udy of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndro me. (19194280)Kazakov D.V.... Michal M.2009CYLD
3Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)Levidou G.... Androulaki A.2009DNTT
4Skin type spiradenoma of the parotid gland with malig nant transformation: report of a case with analysis of the CYLD gene. (19454360)Kazakov D.V.... Skalova A.2009CYLD
5Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)Kurokawa I.... Tsubura A.2007ACTC1
6Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. (9129700)Meybehm M.... Fischer H.P.1997KRT14, KRT7
7Malignant transformation in multiple eccrine spiradenoma (1317754)Husek K.... SamohA1l J.1992KRT7, S100A1

Variations for Spiradenoma

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Expression for genes affiliated with Spiradenoma

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Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Spiradenoma

Pathways for genes affiliated with Spiradenoma

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Compounds for genes affiliated with Spiradenoma

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Sources:
41Novoseek, 55Tocris Bioscience, 11DrugBank, 22HMDB
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Compounds related to spiradenoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1hpvs419.9KRT14, TP53
22-chlorodeoxyadenosine419.6TP53, DNTT
3calcipotriol41 55 1111.5KRT14, KRT15
42-methoxyethanol419.5S100A1, KRT14, ACTC1
5reticulin419.4ACTC1, KRT7
6actomyosin419.3ACTC1, S100A1
7b 723419.0ACTC1, KRT7, S100A1
8retinoid418.8KRT14, KRT7, TP53
9mucicarmine418.8ACTC1, KRT7, KRT14, S100A1
10hematoxylin418.7S100A1, KRT14, KRT7, ACTC1
11iron41 229.6ACTC1, KRT7, KRT14, S100A1
12progesterone41 55 11 2211.3S100A1, KRT14, KRT7, TP53, ACTC1
13estrogen418.2S100A1, KRT14, KRT7, TP53, ACTC1
14paraffin417.9S100A1, KRT14, KRT7, DNTT, TP53, ACTC1
15retinoic acid41 55 229.2S100A1, KRT15, KRT14, KRT7, DNTT, TP53

GO Terms for genes affiliated with Spiradenoma

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15Gene Ontology
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Cellular components related to spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.7KRT7, KRT14, KRT15

Products for genes affiliated with Spiradenoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Spiradenoma

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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