ES
MCID: SPR013
MIFTS: 47

Spiradenoma (ES) malady

Rare diseases, Cancer diseases, Skin diseases, Ear diseases categories
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Summaries for Spiradenoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

MalaCards: Spiradenoma, also known as eccrine spiradenoma, is related to brooke-spiegler syndrome and sarcoma. An important gene associated with Spiradenoma is CYLD (cylindromatosis (turban tumor syndrome)), and among its related pathways are Glucocorticoid receptor regulatory network and Cytoskeleton remodeling Keratin filaments. The compounds hpvs and reticulin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and smooth muscle, and related mouse phenotypes are cellular and normal.

Aliases & Classifications for Spiradenoma

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8Disease Ontology, 10DISEASES, 43NIH Rare Diseases, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases, Ear diseases


Aliases & Descriptions:

spiradenoma 8 10
eccrine spiradenoma 8 43 62
benign eccrine spiradenoma 8 43
eccrine spiradenoma, benign 43
eccrine spiradenoma of skin 8
es 43


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Disease Ontology8 DOID:5444
SNOMED-CT58 4977000, 403938001
NCIt40 C4170

Related Diseases for Spiradenoma

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17GeneCards, 18GeneDecks
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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1brooke-spiegler syndrome30.8CYLD
2sarcoma30.5S100A1, ACTC1, TP53
3syringoma30.2KRT14, S100A1
4glomus tumor30.0ACTC1, S100A1
5adenoid cystic carcinoma30.0CYLD, ACTC1, S100A1, KRT14, KRT7
6teratoma29.9KRT7, ACTC1
7peripheral primitive neuroectodermal tumor29.9S100A1, DNTT
8adenoma29.8TP53, ACTC1, S100A1, KRT14, KRT7
9breast cancer29.6TP53, ACTC1, S100A1, KRT14, KRT15, KRT7
10malignant spiradenoma10.6
11primitive neuroectodermal tumor10.3
12benign eccrine breast spiradenoma10.2
13breast malignant eccrine spiradenoma10.2
14adenoiditis10.2
15adnexal spiradenoma/cylindroma of a sweat gland10.2
16status epilepticus10.2
17neuronitis10.2
18thyroiditis10.2
19urinary schistosomiasis10.1
20schistosomiasis10.1
21sweat gland carcinoma10.1
22meningioma10.1S100A1
23pseudomyxoma peritonei10.1KRT7
24syringocystadenoma papilliferum10.1KRT15, CLEC2A
25alopecia10.1KRT15, CLEC2A
26nephrogenic adenoma10.1KRT7, S100A1
27oxyphilic adenoma10.1KRT7, S100A1
28renal oncocytoma10.1KRT7, S100A1
29acute leukemia10.1
30tetanus neonatorum10.1
31epithelioid sarcoma10.1
32extrapulmonary tuberculosis10.1
33filariasis10.1
34leukemia10.1
35malaria10.1
36pancreatitis10.1
37papillary thyroid carcinoma10.1
38tetanus10.1
39thyroid cancer10.1
40tuberculosis10.1
41hiv-110.1
42cutaneous fibrous histiocytoma10.1S100A1, ACTC1
43dermatofibrosarcoma protuberans10.1S100A1, ACTC1
44hemangiopericytoma10.1S100A1, ACTC1
45angiomyolipoma10.1ACTC1, S100A1
46fibroma10.1ACTC1, S100A1
47fibromatosis10.0ACTC1, S100A1
48smooth muscle tumor10.0ACTC1, S100A1
49malignant peripheral nerve sheath tumor10.0ACTC1, S100A1
50neurofibroma10.0ACTC1, S100A1

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to spiradenoma

Symptoms for Spiradenoma

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Drugs & Therapeutics for Spiradenoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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33MalaCards
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MalaCards organs/tissues related to Spiradenoma:

33
Skin, Breast, Smooth muscle

Animal Models for Spiradenoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Spiradenoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.5TP53, ACTC1, KRT14, KRT7, CYLD
2MP:00028738.0S100A1, DNTT, ACTC1, TP53, CYLD

Publications for Spiradenoma

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52PubMed
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Articles related to Spiradenoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. (24118397)
2013
2
Dermatoscopic pattern of a spiradenoma. (23785623)
2012
3
Malignant eccrine spiradenoma: a meta-analysis of reported cases. (20851376)
2011
4
Giant vascular eccrine spiradenoma. (22148049)
2011
5
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. (21430945)
2011
6
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. (19222500)
2010
7
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. (20075707)
2010
8
Spiradenoma with marked adenomyoepitheliomatous features. (20859082)
2010
9
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. (20483125)
2010
10
Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. (19684510)
2009
11
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
12
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. (20101314)
2009
13
Multiple nodules of the head--clinicopathologic challenge. Multiple eccrine spiradenoma. (19261009)
2009
14
Spiradenoma reminiscent of thymoma: report of a case and review of the literature. (18647207)
2009
15
Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. (19454360)
2009
16
An unusual case of congenital linear eccrine spiradenoma. (19419467)
2009
17
Recurrent atypical eccrine spiradenoma of the forehead. (19181014)
2008
18
MRI appearance of multiple eccrine spiradenoma. (17267467)
2007
19
Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells. (17207189)
2007
20
Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. (16479087)
2006
21
Congenital blaschkoid eccrine spiradenoma on the face. (15757814)
2005
22
Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. (15869542)
2005
23
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
24
Spiradenocarcinoma of the breast arising in a long-standing spiradenoma. (15185264)
2004
25
Eccrine spiradenoma: an unusual presentation with otalgia. (14990930)
2004
26
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. (14989745)
2004
27
Papular lesion of the proximal nail fold. Eccrine spiradenoma. (15313820)
2004
28
Familial eccrine spiradenoma: a case report and review of the literature. (12656824)
2003
29
Multiple eccrine spiradenoma in zosteriform distribution. (12960891)
2003
30
Malignant eccrine spiradenoma occurring on a traumatized area. (12087301)
2002
31
Malignant eccrine spiradenoma: an unusual presentation. (17656974)
2002
32
Extensive naevoid eccrine spiradenoma. (10215788)
1999
33
Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review. (10535577)
1999
34
Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. (10075300)
1999
35
Eccrine spiradenoma mimicking adenoid cystic carcinoma on fine needle aspiration. A case report. (9167714)
1997
36
Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. (8639057)
1996
37
Cutaneous adnexal carcinoma arising within a solitary cylindroma-spiradenoma. (8721596)
1996
38
Eccrine spiradenoma, not poroma. (8634818)
1996
39
An unusual, recurring breast tumor with features of eccrine spiradenoma: a case report. (8929479)
1996
40
Over-expression of p53 protein as an indicator of the malignant transformation in spiradenoma. (7657312)
1995
41
Stump the experts. Eccrine spiradenoma. (8388416)
1993
42
Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach. (1322262)
1992
43
Malignant eccrine spiradenoma. A clinicopathologic study. (1384379)
1992
44
Congenital spiradenoma. (2851273)
1988
45
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
46
Eccrine spiradenoma: clinical and pathologic study of 49 tumors. (6313776)
1983
47
An unusual tumor of the female breast: combined eccrine and apocrine spiradenoma. (6310473)
1983
48
Carcinoma arising in eccrine spiradenoma. (445374)
1979
49
Proceedings: Dermal eccrine cylindroma, epithelioma adenoides cysticum of Brooke, and ecrine spiradenoma. (4375438)
1974
50
Eccrine spiradenoma. Histochemical and electron microscopic studies. (4286974)
1966

Variations for Spiradenoma

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Expression for genes affiliated with Spiradenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for genes affiliated with Spiradenoma

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Spiradenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KRT14, TP53
29.6KRT7, KRT14
39.2KRT15, TP53

Compounds for genes affiliated with Spiradenoma

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45Novoseek, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB
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Compounds related to Spiradenoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1hpvs4510.0KRT14, TP53
2reticulin459.9KRT7, ACTC1
3actomyosin459.8S100A1, ACTC1
42-chlorodeoxyadenosine459.6DNTT, TP53
5methanol45 2410.6KRT7, ACTC1
62-methoxyethanol459.6KRT14, S100A1, ACTC1
7dutp459.6DNTT, TP53
8calcipotriol45 61 29 1112.5KRT15, KRT14
9carboplatin45 51 1111.4DNTT, TP53
10retinoid459.4TP53, KRT14, KRT7
11b 723459.4ACTC1, S100A1, KRT7
12fludarabine45 51 1111.3DNTT, TP53
13butyrate459.3TP53, DNTT, KRT14
14glycogen45 2410.2ACTC1, S100A1, KRT7
15mucicarmine459.1KRT7, KRT14, S100A1, ACTC1
16hematoxylin459.0ACTC1, S100A1, KRT14, KRT7
17iron45 2410.0ACTC1, S100A1, KRT14, KRT7
18cisplatin45 51 61 1111.8TP53, DNTT, KRT14
19progesterone45 29 61 24 1112.6TP53, ACTC1, S100A1, KRT14, KRT7
20estrogen458.6KRT7, KRT14, S100A1, ACTC1, TP53
21tyrosine458.1KRT7, KRT15, KRT14, S100A1, ACTC1
22paraffin458.0TP53, ACTC1, DNTT, S100A1, KRT14, KRT7
23retinoic acid45 248.2TP53, ACTC1, DNTT, S100A1, KRT14, KRT15

GO Terms for genes affiliated with Spiradenoma

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16Gene Ontology
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Cellular components related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.6KRT7, KRT14
2intermediate filamentGO:0058828.5KRT7, KRT15, KRT14

Biological processes related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:0085449.3KRT15, KRT14

Molecular functions related to Spiradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3KRT15, KRT14
2protein bindingGO:0055156.7KRT7, KRT15, KRT14, S100A1, CLEC2A, TP53

Products for genes affiliated with Spiradenoma

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Sources for Spiradenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet