MCID: SPL011
MIFTS: 37

Spleen Cancer

Categories: Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Spleen Cancer

MalaCards integrated aliases for Spleen Cancer:

Name: Spleen Cancer 12 50 14
Splenic Neoplasms 42 69
Splenic Neoplasm 12 50
Spleen Neoplasm 12 50
Malignant Neoplasm of Spleen 69
Malignant Tumour of Spleen 12
Malignant Splenic Tumor 12
Tumor of Spleen 50

Classifications:



External Ids:

Disease Ontology 12 DOID:672
ICD10 33 C26.1
MeSH 42 D013160
NCIt 47 C3383 C3539

Summaries for Spleen Cancer

Disease Ontology : 12 A lymphatic system cancer that affects white blood cells and involves tumor deposits in the spleen.

MalaCards based summary : Spleen Cancer, also known as splenic neoplasms, is related to rectum leiomyoma and colonic l-cell glucagon-like peptide producing tumor. An important gene associated with Spleen Cancer is CYP51A1 (Cytochrome P450 Family 51 Subfamily A Member 1), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cyclophosphamide and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spleen, and related phenotype is immune system.

Related Diseases for Spleen Cancer

Diseases related to Spleen Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Related Disease Score Top Affiliating Genes
1 rectum leiomyoma 10.5 CR2 HBA1
2 colonic l-cell glucagon-like peptide producing tumor 10.4 CD68 HBA1
3 adult central nervous system germinoma 10.4 CD163 CR2
4 esophageal adenosquamous carcinoma 10.4 CD163 CR2
5 squamous blepharitis 10.4 CD68 HBA1
6 rrm2b-related mitochondrial dna depletion syndrome 10.4 CD163 CR2
7 cholelithiasis 10.3 CD68 HBA1
8 mesenteric vascular occlusion 10.3 CD68 HBA1
9 urethral urothelial papilloma 10.3 CD163 CD68
10 tang hsi ryu syndrome 10.3 CD68 CR2
11 common bile duct neoplasm 10.3 CD163 CD68
12 hyperandrogenism 10.3 F8 HBA1
13 polyneuropathy in collagen vascular disease 10.2 CD163 CD68
14 dense deposit disease 10.2 CD68 CR2
15 splenic manifestation of prolymphocytic leukemia 10.2 CD163 CD68
16 dysgraphia 10.2 CD34 HBA1
17 ovarian lymphoma 10.1 CD34 HBA1
18 neurofibroma 10.1 CD34 HBA1
19 pleomorphic adenoma 10.1 CD34 HBA1
20 vulvar dystrophy 10.1 CD34 HBA1
21 spindle cell variant squamous cell breast carcinoma 10.1 CD163 CD68
22 villoglandular endometrial endometrioid adenocarcinoma 10.1 CR2 F8
23 cervical adenoma malignum 10.1 CD34 HBA1
24 cervical endometrial stromal sarcoma 10.1 CD34 HBA1
25 coronary aneurysm 10.1 CD34 HBA1
26 thyroid angiosarcoma 10.1 CD34 HBA1
27 thyroid sarcoma 10.1 CD34 HBA1
28 uremia 10.1 CD34 HBA1
29 hyperlucent lung 10.1 CD34 HBA1
30 vestibule of mouth cancer 10.0 CD34 CR2
31 encephalitozoonosis 10.0 CD34 HBA1
32 rectosigmoid junction neoplasm 10.0 CD34 HBA1
33 teeth hard tissue disease 10.0 CD163 CD68 HBA1
34 fibrosarcoma of bone 10.0 CD34 HBA1
35 extrahepatic biliary papillomatosis 10.0 CD34 CD68
36 filamentary keratitis 10.0 CD34 CD68
37 inner ear cancer 10.0 CD34 CD68
38 tropical spastic paraparesis 9.9 CD34 CD68
39 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 9.9 CD163 CD68 CR2
40 chronic erythremia 9.9 CD68 F8 HBA1
41 childhood brainstem astrocytoma 9.9 CD34 CD68
42 fallopian tube squamous cell carcinoma 9.9 CD34 CD68
43 ossifying fibromyxoid tumor 9.9 CD34 HBA1
44 brain stem infarction 9.9 CD34 CD68
45 neurofibroma of the esophagus 9.9 CD34 CD68
46 bone benign neoplasm 9.9 CD34 HBA1
47 dermoid cyst 9.9 CD34 CYP51A1 HBA1
48 hilar cholangiocellular carcinoma 9.8 CD34 HBA1
49 kidney lipoma 9.8 CD34 CD68
50 central nervous system mature teratoma 9.8 CD34 CD68

Graphical network of the top 20 diseases related to Spleen Cancer:



Diseases related to Spleen Cancer

Symptoms & Phenotypes for Spleen Cancer

MGI Mouse Phenotypes related to Spleen Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CD163 CD34 CD68 CR2 CYP51A1 EPX

Drugs & Therapeutics for Spleen Cancer

Drugs for Spleen Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 475)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
2
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
3 Thiotepa Approved Phase 4,Phase 2,Phase 3 52-24-4 5453
4 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
5 Antilymphocyte Serum Phase 4,Phase 2,Phase 3,Phase 1
6 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
9
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
10
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
11
Cefepime Approved Phase 3,Phase 1 88040-23-7 5479537
12
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
13
Ofloxacin Approved Phase 3 82419-36-1 4583
14
Iron Approved Phase 3,Phase 2,Phase 1 7439-89-6 23925
15
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
16
Idarubicin Approved Phase 3 58957-92-9 42890
17
Melphalan Approved Phase 3,Phase 2,Phase 1 148-82-3 4053 460612
18
Doxorubicin Approved, Investigational Phase 3,Phase 1,Phase 2 23214-92-8 31703
19
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
20
rituximab Approved Phase 3,Phase 1,Phase 2 174722-31-7 10201696
21
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
22
Fludarabine Approved Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
23
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
24
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 498142 38904
25
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1 33419-42-0 36462
26
Cytarabine Approved, Investigational Phase 3,Phase 1,Phase 2 147-94-4 6253
27
Mycophenolate mofetil Approved, Investigational Phase 3,Phase 2,Phase 1 128794-94-5 5281078
28
Mycophenolic acid Approved Phase 3,Phase 2,Phase 1 24280-93-1 446541
29
Chlorambucil Approved Phase 3 305-03-3 2708
30
Vidarabine Approved Phase 3,Phase 2,Phase 1 24356-66-9 32326 21704
31
Vinblastine Approved Phase 3,Phase 1,Phase 2 865-21-4 13342 241903
32
Dalteparin Approved Phase 3 9005-49-6
33
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
35
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
36
Ephedrine Approved Phase 3 299-42-3 9294
37
Pseudoephedrine Approved Phase 3 90-82-4 7028
38
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
39
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 11096-26-7, 209810-58-2
40
Ondansetron Approved Phase 3,Phase 2,Phase 1 99614-02-5 4595
41
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
42
Guaifenesin Approved, Vet_approved Phase 3,Phase 2 93-14-1 3516
43
Morphine Approved, Investigational Phase 3 57-27-2 5288826
44
Palivizumab Approved, Investigational Phase 3 188039-54-5
45
Ribavirin Approved Phase 3 36791-04-5 37542
46
Fluconazole Approved Phase 3 86386-73-4 3365
47
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
48
Piperacillin Approved Phase 3 66258-76-2 43672
49
Tazobactam Approved Phase 3 89786-04-9 123630
50
Vancomycin Approved Phase 3 1404-90-6 441141 14969

Interventional clinical trials:

(show top 50) (show all 597)

id Name Status NCT ID Phase Drugs
1 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
2 Short Term Outcomes of Laparoscopic Intersphincteric Resection for Low Rectal Cancer Unknown status NCT01836926 Phase 2, Phase 3
3 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
4 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
5 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
6 Epoetin Alfa or Epoetin Beta With or Without Iron Infusion in Treating Anemia in Patients With Cancer Unknown status NCT00482716 Phase 3
7 Electroacupuncture Versus Fast-track Perioperative Program for Laparoscopic Colorectal Surgery Unknown status NCT02059603 Phase 3
8 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
9 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
10 Monoclonal Antibodies in Detecting Residual Disease in Patients Who Have Been Treated for Non-Hodgkin's Lymphoma Unknown status NCT00003338 Phase 2, Phase 3
11 GCSSG-SPNX: Trial to Evaluate Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma: JCOG0110 Completed NCT00112099 Phase 3
12 Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic Lymphoma Completed NCT00608374 Phase 3 chlorambucil;fludarabine phosphate
13 Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis Completed NCT01437787 Phase 3 SAR302503;Placebo
14 SWOG-9133 RT w/ or w/o Doxorubicin and Vinblastine in Stage I or Stage II Hodgkin's Disease Completed NCT00002495 Phase 3 doxorubicin hydrochloride;vinblastine
15 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
16 COntrolled MyeloFibrosis Study With ORal JAK Inhibitor Treatment: The COMFORT-I Trial Completed NCT00952289 Phase 3 Ruxolitinib;Placebo
17 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
18 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3
19 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
20 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
21 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
22 Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder Completed NCT00755040 Phase 3 cyclosporine ophthalmic emulsion
23 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
24 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
25 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
26 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
27 Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer Completed NCT00053053 Phase 3
28 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
29 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
30 Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer Completed NCT00265837 Phase 3
31 Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases Completed NCT00438958 Phase 3
32 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
33 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
34 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
35 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
36 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
37 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
38 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
39 Graft-Versus-Host Disease in Treating Patients With Recurrent or Refractory Lymphoma or Hodgkin's Disease Completed NCT00003414 Phase 3 busulfan;cyclophosphamide;cyclosporine
40 Epoetin Alfa in Treating Anemia in Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma and Anemia Caused By Chemotherapy Completed NCT00003341 Phase 3
41 Combination Chemotherapy With or Without Rituximab in Treating Patients With Newly Diagnosed Non-Hodgkin's Lymphoma Completed NCT00004112 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
42 Pegylated Interferon Alpha-2b Versus Hydroxyurea in Polycythemia Vera Completed NCT01949805 Phase 3 Peg-P-IFN-alpha-2b (AOP2014);Hydroxyurea
43 Synergistic Anti-tumor Effect of ChangTai Keli for Colon Cancer Patients Recruiting NCT02510118 Phase 2, Phase 3 mFOLFOX6;XELOX;Placebo ChangTai Keli;ChangTai Keli
44 Surgical Complications Related to Primary or Interval Debulking in Ovarian Neoplasm Recruiting NCT01461850 Phase 3
45 Combined Resection vs. Separated Resection After Mobilization of Splenic Vein During Distal Pancreatectomy Recruiting NCT02871804 Phase 3
46 Trans-anal Versus Laparoscopic TME for Mid and Low Rectal Cancer Recruiting NCT03242187 Phase 2, Phase 3
47 Plerixafor Versus G-CSF in the Treatment of People With WHIM Syndrome Recruiting NCT02231879 Phase 3 Plerixafor;G-CSF
48 D2 Resection and HIPEC (Hyperthermic Intraperitoneal Chemoperfusion) in Locally Advanced Gastric Carcinoma Recruiting NCT01882933 Phase 3 HIPEC (Hyperthermic Intraperitoneal Chemoperfusion) with oxaliplatin
49 Study on Laparoscopic Spleen-Preserving No. 10 Lymph Node Dissection for Advanced Middle or Upper Third Gastric Cancer Active, not recruiting NCT02333721 Phase 3
50 Apixaban or Dalteparin in Reducing Blood Clots in Patients With Cancer Related Venous Thromboembolism Active, not recruiting NCT02585713 Phase 3 Apixaban;Dalteparin

Search NIH Clinical Center for Spleen Cancer

Cochrane evidence based reviews: splenic neoplasms

Genetic Tests for Spleen Cancer

Anatomical Context for Spleen Cancer

MalaCards organs/tissues related to Spleen Cancer:

39
Bone, Bone Marrow, Spleen, B Cells, T Cells, Liver, Kidney

Publications for Spleen Cancer

Variations for Spleen Cancer

Expression for Spleen Cancer

Search GEO for disease gene expression data for Spleen Cancer.

Pathways for Spleen Cancer

Pathways related to Spleen Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.04 CD163 CD34
2 10.87 CD163 CD34 CD68
3 10.68 CD34 CR2

GO Terms for Spleen Cancer

Cellular components related to Spleen Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 CD163 CD34 CD68 CR2 CYP51A1 EMB

Biological processes related to Spleen Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.16 EPX HBA1
2 acute-phase response GO:0006953 8.96 CD163 F8
3 hydrogen peroxide catabolic process GO:0042744 8.62 EPX HBA1

Molecular functions related to Spleen Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX HBA1
2 heme binding GO:0020037 8.8 CYP51A1 EPX HBA1

Sources for Spleen Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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