MCID: SPL005
MIFTS: 32

Splenic Artery Aneurysm malady

Categories: Cardiovascular diseases

Aliases & Classifications for Splenic Artery Aneurysm

Aliases & Descriptions for Splenic Artery Aneurysm:

Name: Splenic Artery Aneurysm 12 14
Aneurysm of Splenic Artery 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14006
ICD9CM 35 442.83
SNOMED-CT 64 70405009
UMLS 69 C0155747

Summaries for Splenic Artery Aneurysm

MalaCards based summary : Splenic Artery Aneurysm, also known as aneurysm of splenic artery, is related to aneurysm and pancreatitis. An important gene associated with Splenic Artery Aneurysm is SAA1 (Serum Amyloid A1), and among its related pathways/superpathways are FOXA1 transcription factor network and Surfactant metabolism. Affiliated tissues include liver, spleen and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and hematopoietic system

Related Diseases for Splenic Artery Aneurysm

Graphical network of the top 20 diseases related to Splenic Artery Aneurysm:



Diseases related to Splenic Artery Aneurysm

Symptoms & Phenotypes for Splenic Artery Aneurysm

GenomeRNAi Phenotypes related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.5 CD163
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.5 CD163
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.5 HCK NF1 CD163
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.5 NF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.5 CD163
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.5 HCK
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.5 CD163
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.5 NF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.5 HCK
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.5 HCK
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.5 CD163
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.5 CD163
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.5 HCK

MGI Mouse Phenotypes related to Splenic Artery Aneurysm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 UBC APCS CD163 HCK NF1 SFTPA1
2 homeostasis/metabolism MP:0005376 9.23 APCS ATP8B1 CD163 HCK NF1 SAA1

Drugs & Therapeutics for Splenic Artery Aneurysm

Interventional clinical trials:


id Name Status NCT ID Phase
1 Comparison Between Open and Laparoscopic Splenic Aneurysms Repair Completed NCT01387828 Phase 3

Search NIH Clinical Center for Splenic Artery Aneurysm

Genetic Tests for Splenic Artery Aneurysm

Anatomical Context for Splenic Artery Aneurysm

MalaCards organs/tissues related to Splenic Artery Aneurysm:

39
Liver, Spleen, Kidney, Pancreas, Colon

Publications for Splenic Artery Aneurysm

Articles related to Splenic Artery Aneurysm:

(show top 50) (show all 336)
id Title Authors Year
1
Splenic artery aneurysm. ( 27982336 )
2016
2
Giant splenic artery aneurysm rupture. ( 27398212 )
2016
3
Splenic artery aneurysm presenting as a submucosal gastric lesion: A case report. ( 27499832 )
2016
4
Surgical management of a splenic artery aneurysm. ( 27190621 )
2016
5
Rebleeding of a Splenic Artery Aneurysm after Coil Embolisation. ( 27872785 )
2016
6
Successful resuscitation after splenic artery aneurysm rupture. ( 26957826 )
2016
7
Splenic artery aneurysm rupture in pregnancy. ( 28069418 )
2016
8
Multiple Giant Splenic Artery Aneurysms Causing Sinistral (Left-Sided) Portal Hypertension. ( 27110411 )
2016
9
Spontaneous rupture of the splenic artery aneurysm: a rare clinical presentation of acute abdomen. ( 27135088 )
2016
10
Computed Tomography Angiography in Diagnosis and Treatment of Splenic Artery Aneurysm. ( 26831243 )
2016
11
Saved from a fatal flight: A ruptured splenic artery aneurysm in a pregnant woman. ( 25617728 )
2015
12
A case of ruptured giant splenic artery aneurysm. ( 25744926 )
2015
13
Endovascular repair of a complex splenic artery aneurysm using a multilayer stent. ( 25918769 )
2015
14
Embolization of a True Giant Splenic Artery Aneurysm Using NBCA Glue - Case Report and Literature Review. ( 25848440 )
2015
15
Hepatobiliary and Pancreatic: A splenic artery aneurysm presenting as a calcified pancreatic mass. ( 25776962 )
2015
16
Idiopathic splenic arteriovenous fistula without splenic artery aneurysm. ( 25903210 )
2015
17
Giant splenic artery aneurysm. ( 25604380 )
2015
18
Combined endovascular embolization and open surgery for splenic artery aneurysm with arteriovenous fistula. ( 26522588 )
2015
19
Splenic artery aneurysm bleeding via the ampulla of Vater. ( 26397850 )
2015
20
Postmortem Computed Tomography Findings in Ruptured Splenic Artery Aneurysm: Value of the Clinical "Sentinel Clot" Sign in Identification of Bleeding Location. ( 26164764 )
2015
21
Splenic Artery Aneurysm in Pregnancy. ( 26605452 )
2015
22
Splenic Artery Aneurysm Invaded by Desmoid-Type Fibromatosis. ( 26017693 )
2015
23
Ruptured splenic artery aneurysm detected by emergency ultrasound-a case report. ( 26069053 )
2015
24
Endovascular Treatment of Splenic Artery Aneurysm With a Stent-Graft: A Case Report. ( 26717355 )
2015
25
Uncommon cause of life-threatening retroperitoneal hemorrhage in a healthy young Hispanic patient: splenic artery aneurysm rupture. ( 26035985 )
2015
26
Management of Giant Splenic Artery Aneurysm: Comprehensive Literature Review. ( 26166071 )
2015
27
Ruptured Splenic Artery Aneurysm: Rare Cause of Shock Diagnosed with Bedside Ultrasound. ( 26587106 )
2015
28
Rupture of maternal splenic artery aneurysm and fetal demise. ( 26152017 )
2015
29
Rupture of splenic artery aneurysm in primipara five days after cesarean section: case report and review of the literature. ( 26373746 )
2015
30
Endoscopic ultrasound-guided thrombin injection in a large splenic artery aneurysm: first report in a patient with tropical chronic pancreatitis. ( 25121631 )
2014
31
Splenic artery aneurysm presenting with abdominal discomfort and weight loss. ( 25092196 )
2014
32
Ruptured splenic artery aneurysm in pregnancy: a case series. ( 25179954 )
2014
33
Ruptured spontaneous splenic artery aneurysm: A case report and review of the literature. ( 25240215 )
2014
34
A case of ruptured splenic artery aneurysm in pregnancy. ( 25574408 )
2014
35
Successful treatment of aberrant splenic artery aneurysm with a combination of coils embolization and covered stents. ( 25176112 )
2014
36
Multiple splenic artery aneurysms: a rare cause of extrahepatic portal hypertension and massive splenomegaly. ( 25386475 )
2014
37
Page kidney secondary to large splenic artery aneurysm bleeding and its management by angioembolization. ( 25032140 )
2014
38
Endovascular retreatment of a splenic artery aneurysm refilled by collateral branches of the left gastric artery: a case report. ( 25515847 )
2014
39
Splenic artery aneurysm: pre-rupture diagnosis is life saving. ( 25427929 )
2014
40
Laparoscopic ligation of proximal splenic artery aneurysm with splenic function preservation. ( 24782641 )
2014
41
Splenic artery aneurysm as an unusual cause of new onset ascites: a case report. ( 24829704 )
2014
42
Early aortal clamping in the surgical treatment of splenic artery aneurysm rupture. ( 24625628 )
2014
43
Anomalous splenic artery aneurysm. ( 23526109 )
2013
44
Multiple splenic artery aneurysms in a patient with portal hypertension. ( 23484244 )
2013
45
Laparoscopic excision of splenic artery aneurysm. ( 23743385 )
2013
46
Splenic artery aneurysm rupture during pregnancy. ( 24589051 )
2013
47
Laparoscopic resection for splenic artery aneurysm using the lateral approach: report of two cases. ( 23602003 )
2013
48
Endovascular Repair of a Complex Splenic Artery Aneurysm Using a Multilayer Stent. ( 24232043 )
2013
49
Stent-assisted coil embolization of a complex wide-neck splenic artery aneurysm. ( 23988548 )
2013
50
Splenic Artery Aneurysm: An Important Cause of Hemoperitoneum and Shock. ( 24140017 )
2013

Variations for Splenic Artery Aneurysm

Expression for Splenic Artery Aneurysm

Search GEO for disease gene expression data for Splenic Artery Aneurysm.

Pathways for Splenic Artery Aneurysm

Pathways related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.92 SFTPA1 SFTPA2
2
Show member pathways
10.79 SFTPA1 SFTPA2
3
Show member pathways
10.78 SFTPA1 SFTPA2 UBC
4
Show member pathways
10.35 SFTPA1 SFTPA2

GO Terms for Splenic Artery Aneurysm

Cellular components related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 APCS CD163 PCSK1N SAA1 SFTPA1 SFTPA2
2 extracellular space GO:0005615 9.43 APCS PCSK1N SAA1 SFTPA1 SFTPA2 UBC
3 clathrin-coated endocytic vesicle GO:0045334 9.16 SFTPA1 SFTPA2
4 lamellar body GO:0042599 8.62 SFTPA1 SFTPA2

Biological processes related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.46 APCS HCK SAA1 UBC
2 toll-like receptor signaling pathway GO:0002224 9.32 SFTPA1 SFTPA2
3 respiratory gaseous exchange GO:0007585 9.26 SFTPA1 SFTPA2
4 acute-phase response GO:0006953 9.13 APCS CD163 SAA1
5 cellular protein metabolic process GO:0044267 9.02 APCS SAA1 SFTPA1 SFTPA2 UBC

Molecular functions related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.13 APCS SFTPA1 SFTPA2
2 lipid transporter activity GO:0005319 8.62 ATP8B1 SFTPA1

Sources for Splenic Artery Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....