MCID: SPL006
MIFTS: 35

Splenic Infarction malady

Rare diseases, Immune diseases categories

Aliases & Classifications for Splenic Infarction

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Aliases & Descriptions for Splenic Infarction:

Name: Splenic Infarction 10 47 12 65 36
Infarct of the Spleen 45
 
Splenic Infarcts 45
Splenic Infarct 10


Classifications:



External Ids:

Disease Ontology10 DOID:2533
MeSH36 D013159

Summaries for Splenic Infarction

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Wikipedia:68 In medicine, splenic infarction is a condition in which oxygen supply to the spleen is interrupted,... more...

MalaCards based summary: Splenic Infarction, also known as infarct of the spleen, is related to sickle cell anemia and protein c deficiency. An important gene associated with Splenic Infarction is HBB (Hemoglobin, Beta), and among its related pathways is Selenium Pathway. Affiliated tissues include spleen, liver and myeloid, and related mouse phenotypes are embryogenesis and homeostasis/metabolism.

Related Diseases for Splenic Infarction

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Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to splenic infarction

Symptoms for Splenic Infarction

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Drugs & Therapeutics for Splenic Infarction

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Drugs for Splenic Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Peginterferon alfa-2bapprovedPhase 329599210-65-8
Synonyms:
215647-85-1
D02748
PEG-Intron
PegIntron
Peginterferon alfa-2b
 
Peginterferon alfa-2b (INN)
Peginterferon alfa-2b (generical recombination)
Peginterferon alfa-2b (generical recombination) (JAN)
Pegintron
Pegintron (TN)
Sylatron
Unitron PEG
2Interferon-alphaPhase 31005
3prolineNutraceuticalPhase 320
4JM 3100Phase 2121

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study to Assess the Self-administration of AOP2014 Using a Pen, Developed for the Treatment of Polycythemia Vera PatientsCompletedNCT02523638Phase 3
2AOP2014 in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.RecruitingNCT02218047Phase 3
3AMD3100 to Mobilize Stem Cells for DonationCompletedNCT00075335Phase 2
4The Spleen in Sickle Cell Anemia and Sickle Cell ThalassemiaCompletedNCT00971698
5Microwave Ablation and Partial Splenic Embolization in the Management of HypersplenismRecruitingNCT02261584
6Immunological Profile in Relation to Cardiac Geometry in HypertensionRecruitingNCT02165241

Search NIH Clinical Center for Splenic Infarction


Cochrane evidence based reviews: Splenic Infarction

Genetic Tests for Splenic Infarction

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Anatomical Context for Splenic Infarction

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MalaCards organs/tissues related to Splenic Infarction:

33
Spleen, Liver, Myeloid, B cells

Animal Models for Splenic Infarction or affiliated genes

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MGI Mouse Phenotypes related to Splenic Infarction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.1F2, HBB, HORMAD1, JAK2
2MP:00053767.7APOH, F2, HBB, HORMAD1, JAK2

Publications for Splenic Infarction

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Articles related to Splenic Infarction:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Incidentally Discovered Splenic Infarction Associated with Scrub Typhus. (26333728)
2015
2
Splenic infarction and malaria. (24942899)
2014
3
Spontaneous massive splenic infarction in the setting of renal transplant and septic shock: a case report and review of the literature. (25317176)
2014
4
Splenic infarction in polycythaemia vera: can the spleen be saved? (25327078)
2014
5
Splenic infarction in P.vivax malaria. (24096848)
2013
6
Splenic infarction as a rare complication of infectious mononucleosis due to Epstein-Barr virus infection in a patient with no significant comorbidity: case report and review of the literature. (23957538)
2013
7
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
8
Plasmodium vivax malaria complicated by splenic infarct. (24090806)
2012
9
Sarcoidosis presenting as massive splenic infarction. (22953152)
2012
10
A 53-year-old female with a 3- to 4-month history of fever, night sweats, lethargy, anorexia, splenic infarction, and worsening mitral valve prolapse. (22345584)
2012
11
Spontaneous splenic infarction in an elderly cirrhotic patient with multiple comorbidities. (23161308)
2012
12
Splenic infarction associated with sorafenib use in a hepatocellular carcinoma patient. (21246003)
2011
13
Splenic infarction associated with rapidly progressive chronic lymphocytic leukemia with complex karyotype and ATM mutation. (21185599)
2011
14
Acute massive splenic infarction with complete liquefaction of the spleen in sickle cell disease. (21982890)
2011
15
Splenic infarction: rare complication of N-butyl-2-cyanoacrylate injection for gastric varices. (20078672)
2010
16
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
17
Splenic infarct is a plausible alternative diagnosis in suspected splenic abscess. (20122618)
2010
18
Abdominal pain increasing during hemodialysis session, do not miss splenic infarction. (21105993)
2010
19
A case of lymphoma presenting as splenic infarction. (21686600)
2009
20
Splenic infarction: a rare cause of acute abdominal pain presenting in an older patient with primary antiphospholipid antibodies syndrome. (19701683)
2009
21
Splenic infarction complicated by splenic artery occlusion after N-butyl-2-cyanoacrylate injection for gastric varices: case report. (15729263)
2005
22
Splenic infarction in a pregnant woman with systemic lupus erythematosus. (15714383)
2005
23
Case report: polycythaemia vera presenting as massive splenic infarction and liquefaction. (15483002)
2004
24
CT diagnosis of splenic infarction in blunt trauma: imaging features, clinical significance and complications. (15041453)
2004
25
The elderly haemodialysis patient with abdominal symptoms and hypovolemic shock--splenic rupture secondary to splenic infarction in a patient with severe atherosclerosis. (10328514)
1999
26
Q-fever associated with splenic infarction and an anti-cardiolipin antibody. (10630667)
1999
27
Splenic infarction caused by idiopathic venous thrombosis. (10228446)
1998
28
Systemic mast cell disease with splenic infarction: a case report. (9704348)
1998
29
Splenic infarction caused by a large thoracic aortic thrombus. (9423725)
1997
30
Splenic infarction in a child with portal hypertension secondary to biliary atresia. (9126779)
1997
31
Splenic infarction: report of three cases of atherosclerotic embolization originating in the aorta and retrospective study of 64 cases. (8997756)
1996
32
Total splenic infarction in acute pancreatitis. (8930045)
1996
33
Isolated splenic infarction following left cardiac catheterization: case report and a review of the literature. (8853144)
1996
34
Splenic infarction from cholesterol embolization following cardiopulmonary bypass. (8745180)
1995
35
Splenic infarction in 16 dogs: a retrospective study. (7674215)
1995
36
Splenic infarction after splenorenal arterial bypass. (8445759)
1993
37
Splenic infarction. Detection by In-111 leukocyte scintigraphy. (1424364)
1992
38
Functional deficiency of protein C associated with mesenteric venous thrombosis and splenic infarction. (2069226)
1991
39
CT scan of the abdomen in the evaluation of splenic infarction. (2308313)
1990
40
Pulmonary embolism and splenic infarction in a patient with sickle cell trait. (2316514)
1990
41
Non-altitude-related splenic infarction in a patient with sickle cell trait. (2686437)
1989
42
Sickle cell trait in a white Jewish family presenting as splenic infarction at high altitude. (3354556)
1988
43
CT patterns of splenic infarction: a clinical and experimental study. (6718733)
1984
44
Splenic infarct associated with diaphragmatic eventration: case report illustrating the non-specificity of splenic focal defects. (709983)
1978
45
Massive splenic infarction in cirrhosis: report of a case with spontaneous disappearance of hypersplenism. (1084843)
1976
46
Splenic infarction in sickle cell-hemoglobin C disease. Demonstration by selective splenic arteriogram and scintillation scan. (949192)
1976
47
Howell-Jolly bodies. A clue to splenic infarction. (1130931)
1975
48
Letter: Splenic infarction in sickle-cell trait: are whites more susceptible? (4852932)
1974
49
Splenic infarction diagnosed by photoscanning. (5033915)
1972
50
Sickle-cell trait and splenic infarction associated with high-altitude flying. (13194086)
1954

Variations for Splenic Infarction

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Expression for genes affiliated with Splenic Infarction

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Search GEO for disease gene expression data for Splenic Infarction.

Pathways for genes affiliated with Splenic Infarction

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Pathways related to Splenic Infarction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2F2, HBB

GO Terms for genes affiliated with Splenic Infarction

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Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:00454299.7HBB, JAK2
2blood coagulation, intrinsic pathwayGO:00075979.7APOH, F2
3negative regulation of fibrinolysisGO:00519189.6APOH, F2
4positive regulation of blood coagulationGO:00301949.5APOH, F2
5regulation of blood coagulationGO:00301939.5APOH, F2
6positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.4F2, JAK2
7blood coagulationGO:00075968.3APOH, F2, HBB, JAK2

Sources for Splenic Infarction

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet