MCID: SPL006
MIFTS: 36

Splenic Infarction malady

Immune category

Summaries for Splenic Infarction

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64Wikipedia, 33MalaCards
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Wikipedia:64 In medicine, splenic infarction is a condition in which oxygen supply to the spleen is interrupted,... more...

MalaCards: Splenic Infarction, also known as infarct of the spleen, is related to autoimmune hemolytic anemia and thalassemia. An important gene associated with Splenic Infarction is APOH (apolipoprotein H (beta-2-glycoprotein I)). The compounds azathioprine and n-acetylglucosamine have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and heart.

Aliases & Classifications for Splenic Infarction

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

splenic infarction 8 10 45 61
infarct of the spleen 43
splenic infarcts 43
splenic infarct 8


External Ids:

Disease Ontology8 DOID:2533
MeSH35 D013159

Related Diseases for Splenic Infarction

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia30.4PIGA
2thalassemia30.2HBB
3sickle cell anemia30.2HBB
4deficiency anemia30.0HBB, PIGA
5splenic disease10.6
6splenic abscess10.5
7wegener's granulomatosis10.4
8hemoglobin d disease10.4
9sickle cell disease10.4
10hemoglobin c disease10.4
11hereditary spherocytosis10.4
12infectious mononucleosis10.4
13acute pancreatitis10.3
14protein s deficiency10.3
15splenic sequestration10.3
16antiphospholipid syndrome10.3
17polycythemia vera10.3
18splenic artery aneurysm10.3
19thrombocytopenia10.3
20sickle cell - hemoglobin d disease10.3
21sickle cell - hemoglobin c disease10.3
22systemic lupus erythematosus10.2
23polyarteritis nodosa10.2
24hemoglobinuria10.2
25portal hypertension10.2
26plasmodium vivax malaria10.2
27situs inversus10.2
28hirschsprung's disease10.2
29toxic shock syndrome10.2
30acute leukemia10.2
31paroxysmal nocturnal hemoglobinuria10.2
32mass syndrome10.2
33pancreatitis, chronic10.2
34sepsis10.2
35venous thrombosis10.2
36typhus10.1
37protein-deficiency anemia10.0
38mitral valve prolapse10.0
39cryoglobulinemia10.0
40letterer-siwe disease10.0
41evans' syndrome10.0
42biliary atresia10.0
43adult respiratory distress syndrome10.0
44beta thalassemia10.0
45mucinous cystadenocarcinoma10.0
46thrombocytosis10.0
47testicular infarct10.0
48leptospirosis10.0
49splenic tuberculosis10.0
50thrombotic thrombocytopenic purpura10.0

Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to splenic infarction

Clinical Features for Splenic Infarction

Drugs & Therapeutics for Splenic Infarction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Splenic Infarction

Anatomical Context for Splenic Infarction

Sources:
33MalaCards
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MalaCards organs/tissues related to Splenic Infarction:

33
Liver, Spleen, Heart, Pancreas, Myeloid, B lymphoblasts, B cells, Pancreatic islet

Animal Models for Splenic Infarction or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Splenic Infarction

Sources:
51PubMed
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Articles related to Splenic Infarction:

(show top 50)    (show all 244)
idTitleAuthorsYear
1
Splenic infarction as a rare complication of infectious mononucleosis due to Epstein-Barr virus infection in a patient with no significant comorbidity: case report and review of the literature. (23957538)
2013
2
Acute splenic infarction in a hiker with previously unrecognised sickle cell trait. (23632180)
2013
3
Splenic infarction in thalassemia major. (23053186)
2013
4
Imaging findings of extensive splenic infarction after cyanoacrylate injection for gastric varices--a case report. (23082456)
2012
5
Splenic infarction and spontaneous rupture in a patient with paratyphoid. (23086034)
2012
6
Acute massive splenic infarction with complete liquefaction of the spleen in sickle cell disease. (21982890)
2011
7
Pancreatic cancer complicated by splenic infarction and abscess. (21991880)
2011
8
Pressurized flight immediately after splenic infarction in two patients with the sickle cell trait. (21235108)
2011
9
Asymptomatic appearance of splenic infarction in Wegener's granulomatosis. (22802831)
2011
10
Massive hemoperitoneum with splenic infarction in Evans syndrome. (21088621)
2011
11
Unusual cardiovascular manifestations of sarcoidosis, a report of three cases: coronary artery aneurysm with myocardial infarction, symptomatic mitral valvular disease, and sudden death from ruptured splenic artery. (19502084)
2010
12
Splenic infarction during Plasmodium ovale acute malaria: first case reported. (20955610)
2010
13
Sickle cell trait as a cause of splenic infarction while climbing Mt. Fuji. (20720368)
2010
14
Splenic infarction: an update on William Osler's observations. (20928991)
2010
15
Splenic infarction in a patient hereditary spherocytosis, protein C deficiency and acute infectious mononucleosis. (18604554)
2008
16
Splenic infarction. A rare presentation of anaplastic pancreatic carcinoma and a review of the literature. (18648141)
2008
17
Splenic infarction in human babesiosis: two cases and discussion. (18171204)
2008
18
Splenic infarction: an unrecognized cause of culture-negative peritonitis in a continuous ambulatory peritoneal dialysis patient. (17969497)
2007
19
Splenic infarction, rare cause of acute abdomen, only seldom requires splenectomy. Case report and literature review. (18510036)
2007
20
Acute splenic infarction. (17696109)
2007
21
Splenic infarction in an African-American male with sickle cell trait. (16924650)
2007
22
Visceral heterotaxia with polysplenia syndrome and haemorrhagic splenic infarction as a rare cause of the acute paediatric abdomen. (16972048)
2006
23
Splenic infarction complicated by splenic artery occlusion after N-butyl-2-cyanoacrylate injection for gastric varices: case report. (15729263)
2005
24
Splenic infarction in Letterer-Siwe disease. (15910461)
2005
25
Case report: polycythaemia vera presenting as massive splenic infarction and liquefaction. (15483002)
2004
26
Cocaine-associated abscesses with lethal sepsis after splenic infarction in an 17-year-old woman. (15013162)
2004
27
Splenic infarction mimicking gastric remnant on PET imaging. (14688596)
2004
28
Asymptomatic splenic infarction in Wegener's granulomatosis. (11796414)
2002
29
A rare cause of acute abdomen: splenic infarction. (11677957)
2001
30
Spontaneous splenic infarction secondary to diabetes-induced microvascular disease. (10693739)
2000
31
Splenic infarction and splenectomy in a jumping horse. (10743977)
2000
32
The elderly haemodialysis patient with abdominal symptoms and hypovolemic shock--splenic rupture secondary to splenic infarction in a patient with severe atherosclerosis. (10328514)
1999
33
Splenic infarction in pregnancy. (10755792)
1999
34
Splenic infarction: report of three cases of atherosclerotic embolization originating in the aorta and retrospective study of 64 cases. (8997756)
1996
35
CT appearance of splenic infarction in Wegener's granulomatosis. (7839968)
1995
36
Late diagnosis of congenital diaphragmatic hernia with splenic infarction presenting as pleural effusion and respiratory distress. (8591683)
1995
37
Splenic infarction after erythropoietin therapy. (8101285)
1993
38
Splenic infarction. Detection by In-111 leukocyte scintigraphy. (1424364)
1992
39
Functional deficiency of protein C associated with mesenteric venous thrombosis and splenic infarction. (2069226)
1991
40
Case report: splenic infarction and acute splenic sequestration in adults with hemoglobin SC disease. (1772123)
1991
41
CT scan of the abdomen in the evaluation of splenic infarction. (2308313)
1990
42
Splenic infarction complicating pediatric liver transplantation: incidence and CT appearance. (2335600)
1990
43
Sickle cell trait in a white Jewish family presenting as splenic infarction at high altitude. (3354556)
1988
44
Hyperferritinaemia associated with splenic infarction. (3818969)
1987
45
Unusual cause of acute abdomen. Sickle cell trait and nonhypoxic splenic infarction. (578831)
1977
46
Scan findings in a case of splenic infarction due to amyloidosis: case report. (966059)
1976
47
Letter: Splenic infarction in sickle-cell trait: are whites more susceptible? (4852932)
1974
48
Diagnosis of splenic infarction by scintillation scanning with Hg203-bromomercurihydroxypropane (Hg203-BMHP). (5451879)
1970
49
Splenic infarction in sicklemia during airplane flight: pathogenesis, hemoglobin analysis and clinical features of six cases. (13292838)
1956
50
Splenic infarction in a patient with sickle-cell-hemoglobin-c disease; report of a case occurring following air travel. (13354018)
1956

Genetic Variations for Splenic Infarction

Expression for genes affiliated with Splenic Infarction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

Pathways for genes affiliated with Splenic Infarction

Compounds for genes affiliated with Splenic Infarction

Sources:
45Novoseek, 50PharmGKB, 2BitterDB, 11DrugBank
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Compounds related to Splenic Infarction according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1azathioprine45 50 2 1112.7APOH, HBB
2n-acetylglucosamine459.7PIGA, CEACAM5
3neomycin459.7CEACAM5, HBB
4latex459.6CEACAM5, APOH
5hydroxyurea45 50 1111.5HBB, BLM
6p003459.5CEACAM5, APOH
7lactate459.3CEACAM5, HBB, APOH
8p002459.3APOH, CEACAM5
9steroid459.1CEACAM5, HBB, APOH

GO Terms for genes affiliated with Splenic Infarction

Products for genes affiliated with Splenic Infarction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Splenic Infarction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet