MCID: SPL009
MIFTS: 25

Splenic Sequestration malady

Summaries for Splenic Sequestration

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32MalaCards
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MalaCards: Splenic Sequestration is related to thrombocytopenia and splenic disease. An important gene associated with Splenic Sequestration is GBA2 (glucosidase, beta (bile acid) 2), and among its related pathways are Platelet activation, signaling and aggregation and Hematopoietic cell lineage. The compounds agarose and hirudin have been mentioned in the context of this disorder.

Aliases & Classifications for Splenic Sequestration

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM
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Aliases & Descriptions:

splenic sequestration 8 10 60


External Ids:

Disease Ontology8 DOID:11786
ICD9CM27 289.52

Related Diseases for Splenic Sequestration

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to splenic sequestration

Clinical Features for Splenic Sequestration

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Drugs & Therapeutics for Splenic Sequestration

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Splenic Sequestration

Search CenterWatch for Splenic Sequestration

Genetic Tests for Splenic Sequestration

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Anatomical Context for Splenic Sequestration

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Animal Models for Splenic Sequestration or affiliated genes

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Publications for Splenic Sequestration

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50PubMed
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Articles related to Splenic Sequestration:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. (22224796)
2012
2
Acute splenic sequestration crisis in an adult with sickle cell anaemia. (22411649)
2012
3
Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration. (23304579)
2012
4
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. (21185577)
2011
5
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
6
Acute splenic sequestration in children with sickle cell anemia. (19668914)
2009
7
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. (19418550)
2009
8
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. (19944213)
2009
9
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. (18084762)
2008
10
Acute splenic sequestration in an adult with hemoglobin S-C disease. (19091280)
2008
11
Determination of hemolytic anemia through the study of (51)Cr red cell survival and splenic sequestration. (18483142)
2008
12
Acute splenic sequestration crisis in an adult with sickle beta-thalassemia. (16705454)
2006
13
Acute splenic sequestration in female children with sickle cell disease in the North of Jordan. (16951418)
2006
14
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. (15108841)
2004
15
Interaction of sickle cell trait with hereditary spherocytosis: splenic infarcts and sequestration. (12486324)
2003
16
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. (17264555)
2001
17
Sudden unexpected death in a patient with splenic sequestration and sickle cell-beta+-thalassemia syndrome. (11305454)
2001
18
Laparoscopic splenectomy for splenic sequestration crisis. (10806537)
2000
19
CT imaging of splenic sequestration in sickle cell disease. (11149089)
2000
20
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. (8615389)
1996
21
Partial splenectomy in children with sickle cell disease and repeated episodes of splenic sequestration. (8936465)
1996
22
Acute splenic sequestration in the absence of palpable splenomegaly. (8166373)
1994
23
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. (1731518)
1992
24
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. (1585908)
1992
25
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. (1564621)
1992
26
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. (1962525)
1991
27
Massive splenic infarction in doubly abnormal heterozygous sickling disorders. A new complication of acute splenic sequestration syndrome. (1815406)
1991
28
Case report: splenic infarction and acute splenic sequestration in adults with hemoglobin SC disease. (1772123)
1991
29
Recurrent acute splenic sequestration crisis due to interacting genetic defects: hemoglobin SC disease and hereditary spherocytosis. (2294990)
1990
30
Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT, and MR imaging findings. (2243976)
1990
31
Long-term management of splenic sequestration in children with sickle cell disease. (2380816)
1990
32
Acute splenic sequestration crises in Saudi children with sickle cell disease. (2473699)
1989
33
Acute splenic sequestration in a 2-month-old infant with sickle cell anemia. (2771560)
1989
34
Acute splenic sequestration in sickle cell disease. (3712147)
1986
35
Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S-C disease. (3976642)
1985
36
Mild splenic sequestration crises in sickle-hemoglobin C disease. (6723180)
1984
37
Acute splenic sequestration in a child with beta +-thalassaemia intermedia. (6404701)
1983
38
Sickle cell disease: acute splenic sequestration crisis. (6666262)
1983
39
Acute splenic sequestration in hemoglobin sickle O-Arab disease. (7382253)
1980
40
Evidence for splenic sequestration of in vivo-labeled erythrocytes. (7438636)
1980
41
Acute splenic sequestration crisis in an adolescent with S-C hemoglobinopathy. (419029)
1979
42
Splenic sequestration and ineffective erythropoiesis in hemoglobin E-beta-thalassemia disease. (724294)
1978
43
Splenic sequestration syndrome in sickle/hemoglobin C disease at low altitude. (874706)
1977
44
Acute splenic sequestration crisis preceded by hypersplenism in haemoglobin SC disease. (843839)
1977
45
(51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy. (4524870)
1974
46
Splenic sequestration and quantitation in reference to haemolytic anaemia. (4752719)
1973
47
Splenic sequestration of 99m Tc-labeled red blood cells. (5080014)
1972
48
Whole-body scanning of 59Fe for evaluating body distribution of erythropoietic marrow, splenic sequestration of red cells and hepatic deposition of iron. (5785661)
1969
49
Studies of selective splenic sequestration of erythrocytes labeled with radioactive mercurihydroxypropane (MHP). (5320959)
1965
50
Alterations in osmotic and mechanical fragility related to in vivo erythrocyte aging and splenic sequestration in hereditary spherocytosis. (13829323)
1960

Genetic Variations for Splenic Sequestration

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Expression for genes affiliated with Splenic Sequestration

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Splenic Sequestration

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Pathways for genes affiliated with Splenic Sequestration

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53Reactome, 29KEGG
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Pathways related to Splenic Sequestration according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1THPO, GP1BA
29.1THPO, GP1BA
3
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9.1THPO, GP1BA

Compounds for genes affiliated with Splenic Sequestration

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44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Splenic Sequestration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agarose449.3CFB, THPO
2hirudin449.3THPO, GP1BA
3latex449.2THPO, GP1BA
4cytochalasin d44 5910.2SLC12A2, GP1BA
5aspirin44 49 28 2412.1THPO, GP1BA
6prostacyclin449.0THPO, GP1BA
7glucose448.2THPO, CFB, GP1BA

GO Terms for genes affiliated with Splenic Sequestration

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16Gene Ontology
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Biological processes related to Splenic Sequestration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.1THPO, GP1BA

Products for genes affiliated with Splenic Sequestration

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  • Antibodies
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  • Antibodies

Sources for Splenic Sequestration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet