MCID: SPL009
MIFTS: 25

Splenic Sequestration malady

Summaries for Splenic Sequestration

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32MalaCards
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MalaCards: Splenic Sequestration is related to thrombocytopenia and splenic disease. An important gene associated with Splenic Sequestration is GBA2 (glucosidase, beta (bile acid) 2), and among its related pathways are Platelet activation, signaling and aggregation and Hematopoietic cell lineage. The compounds agarose and hirudin have been mentioned in the context of this disorder.

Aliases & Classifications for Splenic Sequestration

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM
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Aliases & Descriptions:

splenic sequestration 8 10 60


External Ids:

Disease Ontology8 DOID:11786
ICD9CM27 289.52

Related Diseases for Splenic Sequestration

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to splenic sequestration

Clinical Features for Splenic Sequestration

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Drugs & Therapeutics for Splenic Sequestration

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Splenic Sequestration

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Genetic Tests for Splenic Sequestration

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Anatomical Context for Splenic Sequestration

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Animal Models for Splenic Sequestration or affiliated genes

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Publications for Splenic Sequestration

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50PubMed
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Articles related to Splenic Sequestration:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. (23657515)
2013
2
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. (22224796)
2012
3
Elevated IL-1I+ and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. (22674409)
2012
4
Acute splenic sequestration in children with sickle cell anemia. (19668914)
2009
5
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. (19418550)
2009
6
Acute splenic sequestration in an adult with hemoglobin S-C disease. (19091280)
2008
7
Postpartum acute splenic sequestration in sickle cell disease. (18604687)
2008
8
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. (19092326)
2008
9
Acute splenic sequestration complicating sickle cell disease. (18331593)
2008
10
Acute splenic sequestration crisis in adults with sickle cell anemia. (16924644)
2007
11
Acute splenic sequestration crisis in an adult with sickle beta-thalassemia. (16705454)
2006
12
Fatal splenic sequestration crisis with multiorgan failure in an adult woman with sickle cell-beta+ thalassemia. (15767820)
2005
13
Aplastic crisis and acute splenic sequestration crisis. (10779041)
2000
14
Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. (9607493)
1998
15
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. (8615389)
1996
16
Splenectomy and acute splenic sequestration crises in sickle cell disease. (24057466)
1996
17
Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia. (8969620)
1996
18
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. (8463907)
1993
19
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. (1491841)
1992
20
Acute splenic sequestration in a five-week-old infant with sickle cell disease. (1731016)
1992
21
Hematologic improvement in a patient with Gaucher disease on long-term enzyme replacement therapy: evidence for decreased splenic sequestration and improved red blood cell survival. (1951303)
1991
22
Fatal splenic sequestration crisis in adult sickle cell-beta thalassaemia. (1758801)
1991
23
Management of acute splenic sequestration crisis in sickle cell disease. (2136619)
1990
24
Long-term management of splenic sequestration in children with sickle cell disease. (2380816)
1990
25
Acute splenic sequestration crisis in a young woman with homozygous sickle cell anaemia. (2780458)
1989
26
Acute splenic sequestration in siblings with sickle cell disease. (2456724)
1988
27
Fatal splenic sequestration in adult sickle cell disease. (3365935)
1988
28
Acute splenic sequestration in sickle cell disease. (3712147)
1986
29
Acute splenic sequestration crises in adults with sickle cell disease. (3706382)
1986
30
Acute splenic sequestration in homozygous sickle cell disease: natural history and management. (4020541)
1985
31
Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S-C disease. (3976642)
1985
32
Splenic sequestration in sickle cell disease: role of transfusion therapy. (4073401)
1985
33
Fatal acute splenic sequestration at 4 months of age. (6709430)
1984
34
Acute splenic sequestration in a child with beta +-thalassaemia intermedia. (6404701)
1983
35
Evidence for splenic sequestration of in vivo labeled erythrocytes. (7273547)
1981
36
Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease. (7305414)
1981
37
Splenic sequestration of 99mTc labeled, heat treated red blood cells. (7403531)
1980
38
Evidence for splenic sequestration of in vivo-labeled erythrocytes. (7438636)
1980
39
Fatal splenic sequestration crisis. (484003)
1979
40
Acute splenic sequestration crisis in an adolescent with S-C hemoglobinopathy. (419029)
1979
41
Acute splenic sequestration crisis preceded by hypersplenism in haemoglobin SC disease. (843839)
1977
42
Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes. (1201241)
1975
43
(51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy. (4524870)
1974
44
Red cells life span, splenic sequestration and transfusion requirements in chronic renal failure treated by hemodialysis. Effects of bilateral nephrectomy. (4823492)
1974
45
Splenic sequestration of young erythrocytes in sheep. (4686481)
1973
46
A preliminary study of 51 Cr-labeled platelets for evaluation of splenic sequestration in chronic lymphocytic leukemia. (4739530)
1973
47
Splenic sequestration crisis in childhood myelogenous leukemia. (4515600)
1973
48
Acute splenic sequestration crises (ASSC) in young children with sickle cell anemia. Clinical observations in 20 episodes in 14 children. (4639317)
1972
49
Splenic sequestration of stress erythrocytes in the rabbit. (5414022)
1970
50
Splenic sequestration of heat-treated chromium-51 tagged red cells in hepatosplenic bilharziasis (schistosomiasis). (6032728)
1967

Genetic Variations for Splenic Sequestration

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Expression for genes affiliated with Splenic Sequestration

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Splenic Sequestration

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Pathways for genes affiliated with Splenic Sequestration

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53Reactome, 29KEGG
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Pathways related to Splenic Sequestration according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1THPO, GP1BA
29.1THPO, GP1BA
3
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9.1THPO, GP1BA

Compounds for genes affiliated with Splenic Sequestration

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44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Splenic Sequestration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agarose449.3CFB, THPO
2hirudin449.3THPO, GP1BA
3latex449.2THPO, GP1BA
4cytochalasin d44 5910.2SLC12A2, GP1BA
5aspirin44 49 28 2412.1THPO, GP1BA
6prostacyclin449.0THPO, GP1BA
7glucose448.2THPO, CFB, GP1BA

GO Terms for genes affiliated with Splenic Sequestration

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16Gene Ontology
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Biological processes related to Splenic Sequestration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.1THPO, GP1BA

Products for genes affiliated with Splenic Sequestration

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Splenic Sequestration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet