MCID: SPL009
MIFTS: 28

Splenic Sequestration malady

Category: Immune diseases

Aliases & Classifications for Splenic Sequestration

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Aliases & Descriptions for Splenic Sequestration:

Name: Splenic Sequestration 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:11786
ICD9CM32 289.52

Summaries for Splenic Sequestration

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MalaCards based summary: Splenic Sequestration is related to sickle cell disease and chronic inflammatory demyelinating polyneuritis. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria.

Related Diseases for Splenic Sequestration

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Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to splenic sequestration

Symptoms & Phenotypes for Splenic Sequestration

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Drugs & Therapeutics for Splenic Sequestration

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Drugs for Splenic Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etonogestrelapproved, investigationalPhase 48154048-10-140976, 6917715
Synonyms:
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one
3-Ketodesogestrel
3-Oxodesogestrel
54048-10-1
AC1OCEK1
CHEBI:50777
CHEMBL1531
CID6917715
D04104
 
ETONOGESTREL
Etonogestrel
Etonogestrel (USAN/INN)
Etonogestrelum
Implanon
Implanon (TN)
MolPort-003-847-336
NCGC00168777-01
Org-3236
ZINC11680067
etonogestrelum
├ętonogestrel
2
DesogestrelapprovedPhase 48154024-22-540973
Synonyms:
(17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol
13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol
13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
54024-22-5
AC-308
AC1L24T4
AC1Q282A
C07629
C22H30O
CHEBI:4453
CHEMBL1533
CID40973
Cerazette
D017135
D02367
 
DB00304
DESOGESTREL
Desogestrel (USAN/INN)
Desogestrel [USAN:BAN:INN]
Desogestrelum
Desogestrelum [INN-Latin]
EINECS 258-929-4
HSDB 3593
LMST02030104
LS-62079
MolPort-003-846-424
NCGC00167449-01
ORG 2969
Org-2969
Org2969
Organon Brand of Desogestrel
UNII-81K9V7M3A3
ZINC04097416
alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17
desogen
3ProgestinsPhase 4564
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
5Contraceptive AgentsPhase 41967
6HormonesPhase 414415
7Hormone AntagonistsPhase 413180
8Contraceptives, OralPhase 41327
9
EthylenePhase 43374-85-16325
Synonyms:
Acetene
Athylen
Bicarburretted hydrogen
Elayl
Ethene
Ethene (9CI)
Ethene, 9CI
Ethylene (8CI)
 
Ethylene, compressed [UN1962] [Flammable gas]
Ethylene, pure
Ethylene-CMPD
Etileno
Liquid ethyene
Liquid ethylene
Olefiant gas
Plastipore
Polyethylene as med mol. WT.
10
HydroxyureaapprovedPhase 2223127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase
11Nucleic Acid Synthesis InhibitorsPhase 24962
12ImmunoglobulinsPhase 26394
13AntibodiesPhase 26394
14Antibodies, MonoclonalPhase 24039

Interventional clinical trials:

idNameStatusNCT IDPhase
1Contraception in Women With Sickle Cell DiseaseActive, not recruitingNCT02594462Phase 4
2Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesCompletedNCT01895361Phase 2
3The Spleen in Sickle Cell Anemia and Sickle Cell ThalassemiaCompletedNCT00971698
4Dense Red Blood Cells in Sickle Cell ChildrenRecruitingNCT02887118
5Prognostic Factors of Acute Splenic SequestrationActive, not recruitingNCT01207037

Search NIH Clinical Center for Splenic Sequestration

Genetic Tests for Splenic Sequestration

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Anatomical Context for Splenic Sequestration

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Publications for Splenic Sequestration

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Articles related to Splenic Sequestration:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease. (27047980)
2016
2
Acute Splenic Sequestration Crisis in Adult Sickle Cell Disease: A Report of 16 Cases. (26287797)
2015
3
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. (23657515)
2013
4
Acute splenic sequestration crisis in an adult with sickle cell anaemia. (22411649)
2012
5
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. (22224796)
2012
6
Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration. (23304579)
2012
7
Elevated IL-1I+ and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. (22674409)
2012
8
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. (21185577)
2011
9
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. (19418550)
2009
10
Acute splenic sequestration in children with sickle cell anemia. (19668914)
2009
11
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. (19944213)
2009
12
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
13
Acute splenic sequestration in an adult with hemoglobin S-C disease. (19091280)
2008
14
Acute splenic sequestration complicating sickle cell disease. (18331593)
2008
15
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. (19092326)
2008
16
Postpartum acute splenic sequestration in sickle cell disease. (18604687)
2008
17
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. (18084762)
2008
18
Determination of hemolytic anemia through the study of (51)Cr red cell survival and splenic sequestration. (18483142)
2008
19
Acute splenic sequestration crisis in adults with sickle cell anemia. (16924644)
2007
20
Acute splenic sequestration crisis in an adult with sickle beta-thalassemia. (16705454)
2006
21
Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. (16463155)
2006
22
Acute splenic sequestration in female children with sickle cell disease in the North of Jordan. (16951418)
2006
23
Fatal splenic sequestration crisis with multiorgan failure in an adult woman with sickle cell-beta+ thalassemia. (15767820)
2005
24
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. (15108841)
2004
25
Sudden unexpected death in a patient with splenic sequestration and sickle cell-beta+-thalassemia syndrome. (11305454)
2001
26
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. (17264555)
2001
27
Laparoscopic splenectomy for splenic sequestration crisis. (10806537)
2000
28
Aplastic crisis and acute splenic sequestration crisis. (10779041)
2000
29
CT imaging of splenic sequestration in sickle cell disease. (11149089)
2000
30
Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. (9607493)
1998
31
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. (8615389)
1996
32
Splenectomy and acute splenic sequestration crises in sickle cell disease. (24057466)
1996
33
Partial splenectomy in children with sickle cell disease and repeated episodes of splenic sequestration. (8936465)
1996
34
Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia. (8969620)
1996
35
Acute splenic sequestration in the absence of palpable splenomegaly. (8166373)
1994
36
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. (8463907)
1993
37
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. (1564621)
1992
38
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. (1491841)
1992
39
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. (1585908)
1992
40
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. (1731518)
1992
41
Acute splenic sequestration in a five-week-old infant with sickle cell disease. (1731016)
1992
42
Case report: splenic infarction and acute splenic sequestration in adults with hemoglobin SC disease. (1772123)
1991
43
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. (1962525)
1991
44
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia. (2025582)
1991
45
Fatal splenic sequestration crisis in adult sickle cell-beta thalassaemia. (1758801)
1991
46
Massive splenic infarction in doubly abnormal heterozygous sickling disorders. A new complication of acute splenic sequestration syndrome. (1815406)
1991
47
Hematologic improvement in a patient with Gaucher disease on long-term enzyme replacement therapy: evidence for decreased splenic sequestration and improved red blood cell survival. (1951303)
1991
48
Management of acute splenic sequestration crisis in sickle cell disease. (2136619)
1990
49
Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT, and MR imaging findings. (2243976)
1990
50
Recurrent acute splenic sequestration crisis due to interacting genetic defects: hemoglobin SC disease and hereditary spherocytosis. (2294990)
1990

Variations for Splenic Sequestration

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Expression for genes affiliated with Splenic Sequestration

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Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for genes affiliated with Splenic Sequestration

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GO Terms for genes affiliated with Splenic Sequestration

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Cellular components related to Splenic Sequestration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:007168210.2HBA1, HBB
2haptoglobin-hemoglobin complexGO:00318389.8HBA1, HBB
3ficolin-1-rich granule lumenGO:19048139.5ALAD, HBB
4hemoglobin complexGO:00058339.5HBA1, HBB
5extracellular spaceGO:00056158.8ALAD, HBA1, HBB, THPO

Biological processes related to Splenic Sequestration according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:001570110.1HBA1, HBB
2cellular oxidant detoxificationGO:009886910.1HBA1, HBB
3hydrogen peroxide catabolic processGO:004274410.1HBA1, HBB
4oxygen transportGO:001567110.1HBA1, HBB
5positive regulation of cell deathGO:001094210.0HBA1, HBB
6protein heterooligomerizationGO:005129110.0HBA1, HBB
7response to hydrogen peroxideGO:00425429.5HBA1, HBB

Molecular functions related to Splenic Sequestration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:003172010.1HBA1, HBB
2heme bindingGO:002003710.1HBA1, HBB
3iron ion bindingGO:000550610.0HBA1, HBB
4oxygen bindingGO:00198259.9HBA1, HBB
5oxygen transporter activityGO:00053449.9HBA1, HBB
6peroxidase activityGO:00046019.5HBA1, HBB

Sources for Splenic Sequestration

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet