MCID: SPL009
MIFTS: 26

Splenic Sequestration malady

Summaries for Splenic Sequestration

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33MalaCards
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MalaCards: Splenic Sequestration is related to thrombocytopenia and splenic disease. An important gene associated with Splenic Sequestration is GBA2 (glucosidase, beta (bile acid) 2), and among its related pathways are Platelet activation, signaling and aggregation and Hematopoietic cell lineage. The compounds agarose and hirudin have been mentioned in the context of this disorder. Affiliated tissues include whole blood.

Aliases & Classifications for Splenic Sequestration

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM
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Aliases & Descriptions:

splenic sequestration 8 10 61


External Ids:

Disease Ontology8 DOID:11786
ICD9CM27 289.52

Related Diseases for Splenic Sequestration

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to splenic sequestration

Clinical Features for Splenic Sequestration

Drugs & Therapeutics for Splenic Sequestration

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Splenic Sequestration

Drug clinical trials:

Search ClinicalTrials for Splenic Sequestration

Search NIH Clinical Center for Splenic Sequestration

Search CenterWatch for Splenic Sequestration

Genetic Tests for Splenic Sequestration

Anatomical Context for Splenic Sequestration

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33MalaCards
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MalaCards organs/tissues related to Splenic Sequestration:

33
Whole blood

Animal Models for Splenic Sequestration or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Splenic Sequestration

Sources:
51PubMed
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Articles related to Splenic Sequestration:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. (23657515)
2013
2
Acute splenic sequestration crisis in an adult with sickle cell anaemia. (22411649)
2012
3
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. (21185577)
2011
4
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
5
Determination of hemolytic anemia through the study of (51)Cr red cell survival and splenic sequestration. (18483142)
2008
6
Postpartum acute splenic sequestration in sickle cell disease. (18604687)
2008
7
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. (19092326)
2008
8
Acute splenic sequestration crisis in adults with sickle cell anemia. (16924644)
2007
9
Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. (16463155)
2006
10
Fatal splenic sequestration crisis with multiorgan failure in an adult woman with sickle cell-beta+ thalassemia. (15767820)
2005
11
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. (15108841)
2004
12
Interaction of sickle cell trait with hereditary spherocytosis: splenic infarcts and sequestration. (12486324)
2003
13
Laparoscopic splenectomy for splenic sequestration crisis. (10806537)
2000
14
Aplastic crisis and acute splenic sequestration crisis. (10779041)
2000
15
Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. (9607493)
1998
16
Splenectomy and acute splenic sequestration crises in sickle cell disease. (24057466)
1996
17
Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia. (8969620)
1996
18
Partial splenectomy in children with sickle cell disease and repeated episodes of splenic sequestration. (8936465)
1996
19
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. (8463907)
1993
20
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. (1491841)
1992
21
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. (1564621)
1992
22
Acute splenic sequestration in a five-week-old infant with sickle cell disease. (1731016)
1992
23
Hematologic improvement in a patient with Gaucher disease on long-term enzyme replacement therapy: evidence for decreased splenic sequestration and improved red blood cell survival. (1951303)
1991
24
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia. (2025582)
1991
25
Fatal splenic sequestration crisis in adult sickle cell-beta thalassaemia. (1758801)
1991
26
Management of acute splenic sequestration crisis in sickle cell disease. (2136619)
1990
27
Acute splenic sequestration crisis in a young woman with homozygous sickle cell anaemia. (2780458)
1989
28
Acute splenic sequestration in siblings with sickle cell disease. (2456724)
1988
29
Fatal splenic sequestration in adult sickle cell disease. (3365935)
1988
30
Acute splenic sequestration crises in adults with sickle cell disease. (3706382)
1986
31
Splenic sequestration in sickle cell disease: role of transfusion therapy. (4073401)
1985
32
Fatal acute splenic sequestration at 4 months of age. (6709430)
1984
33
Effect of splenic sequestration of erythrocytes on splenic clearance function and susceptibility to septic peritonitis. (7076309)
1982
34
Evidence for splenic sequestration of in vivo labeled erythrocytes. (7273547)
1981
35
Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease. (7305414)
1981
36
Splenic sequestration of 99mTc labeled, heat treated red blood cells. (7403531)
1980
37
Acute splenic sequestration in hemoglobin sickle O-Arab disease. (7382253)
1980
38
Fatal splenic sequestration crisis. (484003)
1979
39
Splenic sequestration with sickle cell-C disease. (626559)
1978
40
Splenic sequestration syndrome at mountain altitudes in sickle/hemoglobin C disease. (830911)
1977
41
Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes. (1201241)
1975
42
Red cells life span, splenic sequestration and transfusion requirements in chronic renal failure treated by hemodialysis. Effects of bilateral nephrectomy. (4823492)
1974
43
Splenic sequestration of young erythrocytes in sheep. (4686481)
1973
44
A preliminary study of 51 Cr-labeled platelets for evaluation of splenic sequestration in chronic lymphocytic leukemia. (4739530)
1973
45
Splenic sequestration crisis in childhood myelogenous leukemia. (4515600)
1973
46
Acute splenic sequestration crises (ASSC) in young children with sickle cell anemia. Clinical observations in 20 episodes in 14 children. (4639317)
1972
47
Splenic sequestration of stress erythrocytes in the rabbit. (5414022)
1970
48
Whole-body scanning of 59Fe for evaluating body distribution of erythropoietic marrow, splenic sequestration of red cells and hepatic deposition of iron. (5785661)
1969
49
Studies of selective splenic sequestration of erythrocytes labeled with radioactive mercurihydroxypropane (MHP). (5320959)
1965
50
Alterations in osmotic and mechanical fragility related to in vivo erythrocyte aging and splenic sequestration in hereditary spherocytosis. (13829323)
1960

Genetic Variations for Splenic Sequestration

Expression for genes affiliated with Splenic Sequestration

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Splenic Sequestration

Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for genes affiliated with Splenic Sequestration

Sources:
54Reactome, 30KEGG
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Pathways related to Splenic Sequestration according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1THPO, GP1BA
29.1THPO, GP1BA
3
Hide members
9.1THPO, GP1BA

Compounds for genes affiliated with Splenic Sequestration

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Splenic Sequestration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agarose459.3CFB, THPO
2hirudin459.3THPO, GP1BA
3latex459.2THPO, GP1BA
4cytochalasin d45 6010.2SLC12A2, GP1BA
5aspirin45 50 29 2412.1THPO, GP1BA
6prostacyclin459.0THPO, GP1BA
7glucose458.2THPO, CFB, GP1BA

GO Terms for genes affiliated with Splenic Sequestration

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16Gene Ontology
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Biological processes related to Splenic Sequestration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.1THPO, GP1BA

Products for genes affiliated with Splenic Sequestration

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Splenic Sequestration

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet