MCID: SPL009
MIFTS: 28

Splenic Sequestration malady

Categories: Immune diseases

Aliases & Classifications for Splenic Sequestration

Aliases & Descriptions for Splenic Sequestration:

Name: Splenic Sequestration 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11786
ICD9CM 35 289.52
UMLS 69 C1260402

Summaries for Splenic Sequestration

MalaCards based summary : Splenic Sequestration is related to sickle cell disease and chronic inflammatory demyelinating polyneuritis. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria. The drugs Desogestrel and Etonogestrel have been mentioned in the context of this disorder.

Related Diseases for Splenic Sequestration

Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to Splenic Sequestration

Symptoms & Phenotypes for Splenic Sequestration

Drugs & Therapeutics for Splenic Sequestration

Drugs for Splenic Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
3 Contraceptive Agents Phase 4
4 Contraceptives, Oral Phase 4
5
Ethylene Phase 4 74-85-1 6325
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Progestins Phase 4
10
Hydroxyurea Approved Phase 2 127-07-1 3657
11 Antibodies Phase 2
12 Antibodies, Monoclonal Phase 2
13 Immunoglobulins Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4
2 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2
3 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
4 Dense Red Blood Cells in Sickle Cell Children Recruiting NCT02887118
5 Prognostic Factors of Acute Splenic Sequestration Active, not recruiting NCT01207037

Search NIH Clinical Center for Splenic Sequestration

Genetic Tests for Splenic Sequestration

Anatomical Context for Splenic Sequestration

Publications for Splenic Sequestration

Articles related to Splenic Sequestration:

(show top 50) (show all 92)
id Title Authors Year
1
Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease. ( 27047980 )
2016
2
Acute Splenic Sequestration Crisis in Adult Sickle Cell Disease: A Report of 16 Cases. ( 26287797 )
2015
3
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. ( 23657515 )
2013
4
Acute splenic sequestration crisis in an adult with sickle cell anaemia. ( 22411649 )
2012
5
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. ( 22224796 )
2012
6
Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration. ( 23304579 )
2012
7
Elevated IL-1I+ and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. ( 22674409 )
2012
8
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. ( 21185577 )
2011
9
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. ( 19418550 )
2009
10
Acute splenic sequestration in children with sickle cell anemia. ( 19668914 )
2009
11
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. ( 19944213 )
2009
12
Acute splenic sequestration in a cohort of children with sickle cell anemia. ( 19319450 )
2009
13
Acute splenic sequestration in an adult with hemoglobin S-C disease. ( 19091280 )
2008
14
Acute splenic sequestration complicating sickle cell disease. ( 18331593 )
2008
15
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. ( 19092326 )
2008
16
Postpartum acute splenic sequestration in sickle cell disease. ( 18604687 )
2008
17
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. ( 18084762 )
2008
18
Determination of hemolytic anemia through the study of (51)Cr red cell survival and splenic sequestration. ( 18483142 )
2008
19
Acute splenic sequestration crisis in adults with sickle cell anemia. ( 16924644 )
2007
20
Acute splenic sequestration crisis in an adult with sickle beta-thalassemia. ( 16705454 )
2006
21
Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. ( 16463155 )
2006
22
Acute splenic sequestration in female children with sickle cell disease in the North of Jordan. ( 16951418 )
2006
23
Fatal splenic sequestration crisis with multiorgan failure in an adult woman with sickle cell-beta+ thalassemia. ( 15767820 )
2005
24
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. ( 15108841 )
2004
25
Sudden unexpected death in a patient with splenic sequestration and sickle cell-beta+-thalassemia syndrome. ( 11305454 )
2001
26
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. ( 17264555 )
2001
27
Laparoscopic splenectomy for splenic sequestration crisis. ( 10806537 )
2000
28
Aplastic crisis and acute splenic sequestration crisis. ( 10779041 )
2000
29
CT imaging of splenic sequestration in sickle cell disease. ( 11149089 )
2000
30
Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. ( 9607493 )
1998
31
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. ( 8615389 )
1996
32
Splenectomy and acute splenic sequestration crises in sickle cell disease. ( 24057466 )
1996
33
Partial splenectomy in children with sickle cell disease and repeated episodes of splenic sequestration. ( 8936465 )
1996
34
Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia. ( 8969620 )
1996
35
Acute splenic sequestration in the absence of palpable splenomegaly. ( 8166373 )
1994
36
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. ( 8463907 )
1993
37
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. ( 1564621 )
1992
38
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. ( 1491841 )
1992
39
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. ( 1585908 )
1992
40
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. ( 1731518 )
1992
41
Acute splenic sequestration in a five-week-old infant with sickle cell disease. ( 1731016 )
1992
42
Case report: splenic infarction and acute splenic sequestration in adults with hemoglobin SC disease. ( 1772123 )
1991
43
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. ( 1962525 )
1991
44
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia. ( 2025582 )
1991
45
Fatal splenic sequestration crisis in adult sickle cell-beta thalassaemia. ( 1758801 )
1991
46
Massive splenic infarction in doubly abnormal heterozygous sickling disorders. A new complication of acute splenic sequestration syndrome. ( 1815406 )
1991
47
Hematologic improvement in a patient with Gaucher disease on long-term enzyme replacement therapy: evidence for decreased splenic sequestration and improved red blood cell survival. ( 1951303 )
1991
48
Management of acute splenic sequestration crisis in sickle cell disease. ( 2136619 )
1990
49
Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT, and MR imaging findings. ( 2243976 )
1990
50
Recurrent acute splenic sequestration crisis due to interacting genetic defects: hemoglobin SC disease and hereditary spherocytosis. ( 2294990 )
1990

Variations for Splenic Sequestration

Expression for Splenic Sequestration

Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for Splenic Sequestration

GO Terms for Splenic Sequestration

Cellular components related to Splenic Sequestration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ALAD HBA1 HBB THPO
2 ficolin-1-rich granule lumen GO:1904813 9.32 ALAD HBB
3 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBB
4 hemoglobin complex GO:0005833 8.96 HBA1 HBB
5 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBB

Biological processes related to Splenic Sequestration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.4 HBA1 HBB
2 protein heterooligomerization GO:0051291 9.37 HBA1 HBB
3 response to hydrogen peroxide GO:0042542 9.32 HBA1 HBB
4 bicarbonate transport GO:0015701 9.26 HBA1 HBB
5 positive regulation of cell death GO:0010942 9.16 HBA1 HBB
6 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBB
7 oxygen transport GO:0015671 8.62 HBA1 HBB

Molecular functions related to Splenic Sequestration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.37 HBA1 HBB
2 heme binding GO:0020037 9.32 HBA1 HBB
3 oxygen binding GO:0019825 9.26 HBA1 HBB
4 peroxidase activity GO:0004601 9.16 HBA1 HBB
5 oxygen transporter activity GO:0005344 8.96 HBA1 HBB
6 haptoglobin binding GO:0031720 8.62 HBA1 HBB

Sources for Splenic Sequestration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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