MCID: SPL009
MIFTS: 27

Splenic Sequestration malady

Category: Immune diseases

Aliases & Classifications for Splenic Sequestration

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Aliases & Descriptions for Splenic Sequestration:

Name: Splenic Sequestration 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:11786
ICD9CM29 289.52
UMLS65 C1260402

Summaries for Splenic Sequestration

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MalaCards based summary: Splenic Sequestration is related to sickle cell anemia and hemoglobinopathy. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin), and among its related pathways is Factors involved in megakaryocyte development and platelet production. Affiliated tissues include heart, spleen and prostate.

Related Diseases for Splenic Sequestration

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Diseases related to Splenic Sequestration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell anemia29.9HBB, HBD
2hemoglobinopathy29.5HBB, HBD
3sickle cell disease10.5
4splenic abscess10.3HBB, THPO
5thalassemia10.1
6hemoglobin c disease10.1
7thyroid malformation10.1HBB, THPO
8thrombocytopenia10.0
9hereditary spherocytosis10.0
10splenic infarction10.0
11intrapelvic lymph node leukemic reticuloendotheliosis10.0ANK1, HBB
12hypotrichosis-deafness syndrome10.0HBB, HBD
13hemoglobin e disease10.0HBB, HBD
14cyanosis, transient neonatal9.9HBB, HBD
15panophthalmitis9.9HBB, HBD
16basal cell carcinoma9.9HBB, HBD
17active peptic ulcer disease9.9HBB, HBD
18marantic endocarditis9.9HBB, HBD
19hepatitis9.9
20leukemia9.9
21hypersplenism9.9
22splenomegaly9.9
23swayback9.9HBB, HBD
24malignant hypertension9.9HBB, HBD
25hemophagocytic lymphohistiocytosis9.9ANK1, HBB
26generalized anxiety disorder9.9HBB, HBD
27endometrial adenocarcinoma9.9HBB, HBD
28mental retardation, x-linked 39.8HBB, HBD
29congenital nonspherocytic hemolytic anemia9.8HBB, HBD
30protoporphyria, erythropoietic, x-linked9.8HBB, HBD
31hemoglobin h disease, nondeletional9.8HBB, HBD
32qazi markouizos syndrome9.8HBB, HBD
33chronic lymphocytic leukemia9.8
34hemolytic anemia9.8
35schistosomiasis9.8
36peritonitis9.8
37sickle beta thalassemia9.8
38tendinitis9.7HBB, THPO
39thromboangiitis obliterans9.6HBB, HBD
40y-linked disease9.5HBB, HBD
41malignant adult ependymoma9.5ANK1, HBB, HBD
42snyder-robinson syndrome9.4BCAM, HBB, HBD
43chronic congestive splenomegaly8.0ANK1, BCAM, GBA2, HBB, HBD, THPO

Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to splenic sequestration

Symptoms for Splenic Sequestration

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Drugs & Therapeutics for Splenic Sequestration

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Drugs for Splenic Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etonogestrelapproved, investigationalPhase 47254048-10-140976, 6917715
Synonyms:
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one
3-Ketodesogestrel
3-Oxodesogestrel
54048-10-1
AC1OCEK1
CHEBI:50777
CHEMBL1531
CID6917715
D04104
 
ETONOGESTREL
Etonogestrel (USAN/INN)
Etonogestrelum
Implanon
Implanon (TN)
MolPort-003-847-336
NCGC00168777-01
Nexplanon
Org-3236
ZINC11680067
etonogestrelum
2
DesogestrelapprovedPhase 44954024-22-540973
Synonyms:
(17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol
13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol
13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
54024-22-5
AC-308
AC1L24T4
AC1Q282A
C07629
C22H30O
CHEBI:4453
CHEMBL1533
CID40973
Cerazette
D017135
D02367
 
DB00304
DESOGESTREL
Desogestrel (USAN/INN)
Desogestrel [USAN:BAN:INN]
Desogestrelum
Desogestrelum [INN-Latin]
EINECS 258-929-4
HSDB 3593
LMST02030104
LS-62079
MolPort-003-846-424
NCGC00167449-01
ORG 2969
Org-2969
Org2969
Organon Brand of Desogestrel
UNII-81K9V7M3A3
ZINC04097416
alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17
desogen
3Contraceptive AgentsPhase 41706
4ProgestinsPhase 4433
5
EthylenePhase 42774-85-16325
Synonyms:
Acetene
Athylen
Bicarburretted hydrogen
Elayl
Ethene
Ethene (9CI)
Ethene, 9CI
Ethylene (8CI)
 
Ethylene, compressed [UN1962] [Flammable gas]
Ethylene, pure
Ethylene-CMPD
Etileno
Liquid ethyene
Liquid ethylene
Olefiant gas
Plastipore
Polyethylene as med mol. WT.
6
HydroxyureaapprovedPhase 2188127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase
7Nucleic Acid Synthesis InhibitorsPhase 23836
8ImmunoglobulinsPhase 24477
9Antibodies, MonoclonalPhase 22413
10AntibodiesPhase 24477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Contraception in Women With Sickle Cell DiseaseActive, not recruitingNCT02594462Phase 4
2Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesCompletedNCT01895361Phase 2
3The Spleen in Sickle Cell Anemia and Sickle Cell ThalassemiaCompletedNCT00971698
4Prognostic Factors of Acute Splenic SequestrationActive, not recruitingNCT01207037

Search NIH Clinical Center for Splenic Sequestration

Genetic Tests for Splenic Sequestration

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Anatomical Context for Splenic Sequestration

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MalaCards organs/tissues related to Splenic Sequestration:

33
Heart, Spleen, Prostate, Thyroid, Endothelial, T cells, Cervix

Animal Models for Splenic Sequestration or affiliated genes

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Publications for Splenic Sequestration

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Articles related to Splenic Sequestration:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease. (27047980)
2016
2
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. (23657515)
2013
3
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. (22224796)
2012
4
Acute splenic sequestration crisis in an adult with sickle cell anaemia. (22411649)
2012
5
Elevated IL-1I+ and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. (22674409)
2012
6
Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration. (23304579)
2012
7
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. (21185577)
2011
8
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
9
Acute splenic sequestration in children with sickle cell anemia. (19668914)
2009
10
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. (19418550)
2009
11
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. (19944213)
2009
12
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. (18084762)
2008
13
Acute splenic sequestration in an adult with hemoglobin S-C disease. (19091280)
2008
14
Acute splenic sequestration crisis in adults with sickle cell anemia. (16924644)
2007
15
Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. (16463155)
2006
16
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. (15108841)
2004
17
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. (17264555)
2001
18
Laparoscopic splenectomy for splenic sequestration crisis. (10806537)
2000
19
Aplastic crisis and acute splenic sequestration crisis. (10779041)
2000
20
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. (8615389)
1996
21
Splenectomy and acute splenic sequestration crises in sickle cell disease. (24057466)
1996
22
Acute splenic sequestration in the absence of palpable splenomegaly. (8166373)
1994
23
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. (8463907)
1993
24
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. (1731518)
1992
25
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. (1491841)
1992
26
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. (1585908)
1992
27
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. (1564621)
1992
28
Hematologic improvement in a patient with Gaucher disease on long-term enzyme replacement therapy: evidence for decreased splenic sequestration and improved red blood cell survival. (1951303)
1991
29
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia. (2025582)
1991
30
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. (1962525)
1991
31
Management of acute splenic sequestration crisis in sickle cell disease. (2136619)
1990
32
Recurrent acute splenic sequestration crisis due to interacting genetic defects: hemoglobin SC disease and hereditary spherocytosis. (2294990)
1990
33
Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT, and MR imaging findings. (2243976)
1990
34
Acute splenic sequestration crises in Saudi children with sickle cell disease. (2473699)
1989
35
Acute splenic sequestration in siblings with sickle cell disease. (2456724)
1988
36
Acute splenic sequestration in sickle cell disease. (3712147)
1986
37
Acute splenic sequestration crises in adults with sickle cell disease. (3706382)
1986
38
Acute splenic sequestration in a child with beta +-thalassaemia intermedia. (6404701)
1983
39
Evidence for splenic sequestration of in vivo labeled erythrocytes. (7273547)
1981
40
Splenic sequestration of 99mTc labeled, heat treated red blood cells. (7403531)
1980
41
Acute splenic sequestration in hemoglobin sickle O-Arab disease. (7382253)
1980
42
Evidence for splenic sequestration of in vivo-labeled erythrocytes. (7438636)
1980
43
Splenic sequestration syndrome in sickle/hemoglobin C disease at low altitude. (874706)
1977
44
Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes. (1201241)
1975
45
(51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy. (4524870)
1974
46
Red cells life span, splenic sequestration and transfusion requirements in chronic renal failure treated by hemodialysis. Effects of bilateral nephrectomy. (4823492)
1974
47
Splenic sequestration of young erythrocytes in sheep. (4686481)
1973
48
Acute splenic sequestration crises (ASSC) in young children with sickle cell anemia. Clinical observations in 20 episodes in 14 children. (4639317)
1972
49
Splenic sequestration of 99m Tc-labeled red blood cells. (5080014)
1972
50
Splenic sequestration of stress erythrocytes in the rabbit. (5414022)
1970

Variations for Splenic Sequestration

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Expression for genes affiliated with Splenic Sequestration

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Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for genes affiliated with Splenic Sequestration

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Pathways related to Splenic Sequestration according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.2HBB, HBD

GO Terms for genes affiliated with Splenic Sequestration

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Sources for Splenic Sequestration

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet