MCID: SPL009
MIFTS: 28

Splenic Sequestration malady

Category: Immune diseases

Aliases & Classifications for Splenic Sequestration

About this section

Aliases & Descriptions for Splenic Sequestration:

Name: Splenic Sequestration 11 13 67

Classifications:



External Ids:

Disease Ontology11 DOID:11786
ICD9CM31 289.52

Summaries for Splenic Sequestration

About this section
MalaCards based summary: Splenic Sequestration is related to splenic infarction and sickle cell anemia. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria. Affiliated tissues include spleen.

Related Diseases for Splenic Sequestration

About this section

Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to splenic sequestration

Symptoms for Splenic Sequestration

About this section

Drugs & Therapeutics for Splenic Sequestration

About this section

Drugs for Splenic Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etonogestrelapproved, investigationalPhase 47754048-10-140976, 6917715
Synonyms:
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one
3-Ketodesogestrel
3-Oxodesogestrel
54048-10-1
AC1OCEK1
CHEBI:50777
CHEMBL1531
CID6917715
 
D04104
ETONOGESTREL
Etonogestrel (USAN/INN)
Etonogestrelum
Implanon
Implanon (TN)
MolPort-003-847-336
NCGC00168777-01
Org-3236
ZINC11680067
etonogestrelum
2
DesogestrelapprovedPhase 48054024-22-540973
Synonyms:
(17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol
13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol
13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
54024-22-5
AC-308
AC1L24T4
AC1Q282A
C07629
C22H30O
CHEBI:4453
CHEMBL1533
CID40973
Cerazette
D017135
D02367
 
DB00304
DESOGESTREL
Desogestrel (USAN/INN)
Desogestrel [USAN:BAN:INN]
Desogestrelum
Desogestrelum [INN-Latin]
EINECS 258-929-4
HSDB 3593
LMST02030104
LS-62079
MolPort-003-846-424
NCGC00167449-01
ORG 2969
Org-2969
Org2969
Organon Brand of Desogestrel
UNII-81K9V7M3A3
ZINC04097416
alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17
desogen
3ProgestinsPhase 4546
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
5Contraceptive AgentsPhase 41901
6HormonesPhase 413979
7Hormone AntagonistsPhase 412778
8Contraceptives, OralPhase 41292
9
EthylenePhase 43274-85-16325
Synonyms:
Acetene
Athylen
Bicarburretted hydrogen
Elayl
Ethene
Ethene (9CI)
Ethene, 9CI
Ethylene (8CI)
 
Ethylene, compressed [UN1962] [Flammable gas]
Ethylene, pure
Ethylene-CMPD
Etileno
Liquid ethyene
Liquid ethylene
Olefiant gas
Plastipore
Polyethylene as med mol. WT.
10
HydroxyureaapprovedPhase 2215127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase
11Nucleic Acid Synthesis InhibitorsPhase 24855
12ImmunoglobulinsPhase 26045
13AntibodiesPhase 26045
14Antibodies, MonoclonalPhase 23795

Interventional clinical trials:

idNameStatusNCT IDPhase
1Contraception in Women With Sickle Cell DiseaseActive, not recruitingNCT02594462Phase 4
2Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesCompletedNCT01895361Phase 2
3The Spleen in Sickle Cell Anemia and Sickle Cell ThalassemiaCompletedNCT00971698
4Dense Red Blood Cells in Sickle Cell ChildrenRecruitingNCT02887118
5Prognostic Factors of Acute Splenic SequestrationActive, not recruitingNCT01207037

Search NIH Clinical Center for Splenic Sequestration

Genetic Tests for Splenic Sequestration

About this section

Anatomical Context for Splenic Sequestration

About this section

MalaCards organs/tissues related to Splenic Sequestration:

35
Spleen

Animal Models for Splenic Sequestration or affiliated genes

About this section

Publications for Splenic Sequestration

About this section

Articles related to Splenic Sequestration:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Acute Splenic Sequestration Crisis in Adult Sickle Cell Disease: A Report of 16 Cases. (26287797)
2015
2
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. (22224796)
2012
3
Acute splenic sequestration crisis in an adult with sickle cell anaemia. (22411649)
2012
4
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. (21185577)
2011
5
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
6
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. (19418550)
2009
7
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. (19944213)
2009
8
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. (18084762)
2008
9
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. (19092326)
2008
10
Acute splenic sequestration crisis in an adult with sickle beta-thalassemia. (16705454)
2006
11
Acute splenic sequestration in female children with sickle cell disease in the North of Jordan. (16951418)
2006
12
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. (15108841)
2004
13
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. (17264555)
2001
14
Sudden unexpected death in a patient with splenic sequestration and sickle cell-beta+-thalassemia syndrome. (11305454)
2001
15
Laparoscopic splenectomy for splenic sequestration crisis. (10806537)
2000
16
Aplastic crisis and acute splenic sequestration crisis. (10779041)
2000
17
CT imaging of splenic sequestration in sickle cell disease. (11149089)
2000
18
Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. (9607493)
1998
19
Splenectomy and acute splenic sequestration crises in sickle cell disease. (24057466)
1996
20
Partial splenectomy in children with sickle cell disease and repeated episodes of splenic sequestration. (8936465)
1996
21
Acute splenic sequestration in the absence of palpable splenomegaly. (8166373)
1994
22
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. (1491841)
1992
23
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. (1585908)
1992
24
Acute splenic sequestration in a five-week-old infant with sickle cell disease. (1731016)
1992
25
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. (1731518)
1992
26
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. (1962525)
1991
27
Massive splenic infarction in doubly abnormal heterozygous sickling disorders. A new complication of acute splenic sequestration syndrome. (1815406)
1991
28
Management of acute splenic sequestration crisis in sickle cell disease. (2136619)
1990
29
Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT, and MR imaging findings. (2243976)
1990
30
Long-term management of splenic sequestration in children with sickle cell disease. (2380816)
1990
31
Acute splenic sequestration crisis in a young woman with homozygous sickle cell anaemia. (2780458)
1989
32
Fatal splenic sequestration in adult sickle cell disease. (3365935)
1988
33
Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S-C disease. (3976642)
1985
34
Mild splenic sequestration crises in sickle-hemoglobin C disease. (6723180)
1984
35
Fatal acute splenic sequestration at 4 months of age. (6709430)
1984
36
Acute splenic sequestration in a child with beta +-thalassaemia intermedia. (6404701)
1983
37
Sickle cell disease: acute splenic sequestration crisis. (6666262)
1983
38
Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease. (7305414)
1981
39
Splenic sequestration of 99mTc labeled, heat treated red blood cells. (7403531)
1980
40
Fatal splenic sequestration crisis. (484003)
1979
41
Splenic sequestration with sickle cell-C disease. (626559)
1978
42
Splenic sequestration syndrome in sickle/hemoglobin C disease at low altitude. (874706)
1977
43
Splenic sequestration syndrome at mountain altitudes in sickle/hemoglobin C disease. (830911)
1977
44
Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes. (1201241)
1975
45
(51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy. (4524870)
1974
46
Splenic sequestration of young erythrocytes in sheep. (4686481)
1973
47
A preliminary study of 51 Cr-labeled platelets for evaluation of splenic sequestration in chronic lymphocytic leukemia. (4739530)
1973
48
Acute splenic sequestration crises (ASSC) in young children with sickle cell anemia. Clinical observations in 20 episodes in 14 children. (4639317)
1972
49
Whole-body scanning of 59Fe for evaluating body distribution of erythropoietic marrow, splenic sequestration of red cells and hepatic deposition of iron. (5785661)
1969
50
Alterations in osmotic and mechanical fragility related to in vivo erythrocyte aging and splenic sequestration in hereditary spherocytosis. (13829323)
1960

Variations for Splenic Sequestration

About this section

Expression for genes affiliated with Splenic Sequestration

About this section
Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for genes affiliated with Splenic Sequestration

About this section

Pathways related to Splenic Sequestration according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5HBA1, HBB
29.5HBA1, HBB
39.5HBA1, HBB

GO Terms for genes affiliated with Splenic Sequestration

About this section

Cellular components related to Splenic Sequestration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:003183810.1HBA1, HBB
2endocytic vesicle lumenGO:00716829.8HBA1, HBB
3blood microparticleGO:00725629.5HBA1, HBB
4hemoglobin complexGO:00058339.2HBA1, HBB

Biological processes related to Splenic Sequestration according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hydrogen peroxide catabolic processGO:004274410.0HBA1, HBB
2response to hydrogen peroxideGO:00425429.8HBA1, HBB
3bicarbonate transportGO:00157019.8HBA1, HBB
4cellular oxidant detoxificationGO:00988699.8HBA1, HBB
5oxygen transportGO:00156719.7HBA1, HBB
6protein heterooligomerizationGO:00512919.7HBA1, HBB
7positive regulation of cell deathGO:00109429.5HBA1, HBB
8receptor-mediated endocytosisGO:00068989.2HBA1, HBB

Molecular functions related to Splenic Sequestration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:003172010.1HBA1, HBB
2peroxidase activityGO:000460110.1HBA1, HBB
3oxygen transporter activityGO:000534410.1HBA1, HBB
4oxygen bindingGO:00198259.5HBA1, HBB
5heme bindingGO:00200379.5HBA1, HBB
6iron ion bindingGO:00055069.2HBA1, HBB

Sources for Splenic Sequestration

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet