MCID: SPL009
MIFTS: 25

Splenic Sequestration

Categories: Immune diseases

Aliases & Classifications for Splenic Sequestration

MalaCards integrated aliases for Splenic Sequestration:

Name: Splenic Sequestration 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11786
ICD9CM 34 289.52
UMLS 69 C1260402

Summaries for Splenic Sequestration

MalaCards based summary : Splenic Sequestration is related to sickle cell disease and sickle cell anemia. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin). The drugs Desogestrel and Etonogestrel have been mentioned in the context of this disorder. Affiliated tissues include spleen.

Related Diseases for Splenic Sequestration

Diseases related to Splenic Sequestration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 30.4 BCAM HBB
2 sickle cell anemia 10.2
3 thalassemia 10.1
4 beta-thalassemia 10.1
5 splenic disease 10.1 HBB THPO
6 hemoglobin c disease 10.0
7 thrombocytopenia 10.0
8 hereditary spherocytosis 10.0
9 splenic infarction 10.0
10 immune system disease 9.9 HBB THPO
11 anemia, sideroblastic, 1 9.9 ALAD HBB
12 aging 9.9
13 hepatitis 9.9
14 leukemia 9.9
15 hypersplenism 9.9
16 splenomegaly 9.9
17 polycythemia 9.9 HBB THPO
18 leukemia, chronic lymphocytic 2 9.7
19 leukemia, chronic lymphocytic 9.7
20 schistosoma mansoni infection, susceptibility/ 9.7
21 hemolytic anemia 9.7
22 schistosomiasis 9.7
23 acute chest syndrome 9.7
24 hemoglobinopathy 9.7
25 peritonitis 9.7
26 leukemia, b-cell, chronic 9.7
27 sickle beta thalassemia 9.7
28 hemoglobin e-beta-thalassemia syndrome 9.7
29 deficiency anemia 9.7 HBB THPO

Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to Splenic Sequestration

Symptoms & Phenotypes for Splenic Sequestration

Drugs & Therapeutics for Splenic Sequestration

Drugs for Splenic Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
3 Contraceptive Agents Phase 4
4 Contraceptives, Oral Phase 4
5
Ethylene Phase 4 74-85-1 6325
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Progestins Phase 4
10
Hydroxyurea Approved Phase 2 127-07-1 3657
11 Antibodies Phase 2
12 Antibodies, Monoclonal Phase 2
13 Immunoglobulins Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
2 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
3 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Adult Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
4 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
5 Prognostic Factors of Acute Splenic Sequestration Active, not recruiting NCT01207037
6 Dense Red Blood Cells in Sickle Cell Children Active, not recruiting NCT02887118

Search NIH Clinical Center for Splenic Sequestration

Genetic Tests for Splenic Sequestration

Anatomical Context for Splenic Sequestration

MalaCards organs/tissues related to Splenic Sequestration:

38
Spleen

Publications for Splenic Sequestration

Articles related to Splenic Sequestration:

(show top 50) (show all 94)
# Title Authors Year
1
Double whammy- acute splenic sequestration crisis in patient with aplastic crisis due to acute parvovirus infection. ( 28808516 )
2017
2
Acute Splenic Sequestration Crisis After Red Blood Cell Exchange for Acute Chest Syndrome in an Adult With Sickle I^-Thalassemia: What Went Wrong? ( 29205801 )
2017
3
Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease. ( 27047980 )
2016
4
Acute Splenic Sequestration Crisis in Adult Sickle Cell Disease: A Report of 16 Cases. ( 26287797 )
2015
5
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. ( 23657515 )
2013
6
Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration. ( 23304579 )
2012
7
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. ( 22224796 )
2012
8
Acute splenic sequestration crisis in an adult with sickle cell anaemia. ( 22411649 )
2012
9
Elevated IL-1I+ and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. ( 22674409 )
2012
10
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. ( 21185577 )
2011
11
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. ( 19418550 )
2009
12
Acute splenic sequestration in children with sickle cell anemia. ( 19668914 )
2009
13
Acute splenic sequestration in a cohort of children with sickle cell anemia. ( 19319450 )
2009
14
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. ( 19944213 )
2009
15
Acute splenic sequestration in an adult with hemoglobin S-C disease. ( 19091280 )
2008
16
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. ( 18084762 )
2008
17
Acute splenic sequestration complicating sickle cell disease. ( 18331593 )
2008
18
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. ( 19092326 )
2008
19
Postpartum acute splenic sequestration in sickle cell disease. ( 18604687 )
2008
20
Determination of hemolytic anemia through the study of (51)Cr red cell survival and splenic sequestration. ( 18483142 )
2008
21
Acute splenic sequestration crisis in adults with sickle cell anemia. ( 16924644 )
2007
22
Acute splenic sequestration crisis in an adult with sickle beta-thalassemia. ( 16705454 )
2006
23
Acute splenic sequestration in female children with sickle cell disease in the North of Jordan. ( 16951418 )
2006
24
Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. ( 16463155 )
2006
25
Fatal splenic sequestration crisis with multiorgan failure in an adult woman with sickle cell-beta+ thalassemia. ( 15767820 )
2005
26
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. ( 15108841 )
2004
27
Sudden unexpected death in a patient with splenic sequestration and sickle cell-beta+-thalassemia syndrome. ( 11305454 )
2001
28
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. ( 17264555 )
2001
29
Aplastic crisis and acute splenic sequestration crisis. ( 10779041 )
2000
30
Laparoscopic splenectomy for splenic sequestration crisis. ( 10806537 )
2000
31
CT imaging of splenic sequestration in sickle cell disease. ( 11149089 )
2000
32
Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. ( 9607493 )
1998
33
Splenectomy and acute splenic sequestration crises in sickle cell disease. ( 24057466 )
1996
34
Partial splenectomy in children with sickle cell disease and repeated episodes of splenic sequestration. ( 8936465 )
1996
35
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. ( 8615389 )
1996
36
Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia. ( 8969620 )
1996
37
Acute splenic sequestration in the absence of palpable splenomegaly. ( 8166373 )
1994
38
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. ( 8463907 )
1993
39
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. ( 1564621 )
1992
40
Acute splenic sequestration in a five-week-old infant with sickle cell disease. ( 1731016 )
1992
41
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. ( 1491841 )
1992
42
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. ( 1585908 )
1992
43
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. ( 1731518 )
1992
44
Case report: splenic infarction and acute splenic sequestration in adults with hemoglobin SC disease. ( 1772123 )
1991
45
Hematologic improvement in a patient with Gaucher disease on long-term enzyme replacement therapy: evidence for decreased splenic sequestration and improved red blood cell survival. ( 1951303 )
1991
46
Fatal splenic sequestration crisis in adult sickle cell-beta thalassaemia. ( 1758801 )
1991
47
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. ( 1962525 )
1991
48
Massive splenic infarction in doubly abnormal heterozygous sickling disorders. A new complication of acute splenic sequestration syndrome. ( 1815406 )
1991
49
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia. ( 2025582 )
1991
50
Recurrent acute splenic sequestration crisis due to interacting genetic defects: hemoglobin SC disease and hereditary spherocytosis. ( 2294990 )
1990

Variations for Splenic Sequestration

Expression for Splenic Sequestration

Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for Splenic Sequestration

GO Terms for Splenic Sequestration

Cellular components related to Splenic Sequestration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 ALAD HBB KLK8 THPO
2 ficolin-1-rich granule lumen GO:1904813 9.16 ALAD HBB
3 extracellular region GO:0005576 9.02 ALAD BCAM HBB KLK8 THPO

Sources for Splenic Sequestration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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