MCID: SPL009
MIFTS: 23

Splenic Sequestration malady

Immune diseases category

Aliases & Classifications for Splenic Sequestration

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Aliases & Descriptions for Splenic Sequestration:

Name: Splenic Sequestration 10 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:11786
ICD9CM29 289.52

Summaries for Splenic Sequestration

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MalaCards based summary: Splenic Sequestration is related to sickle cell disease and sickle cell anemia. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin), and among its related pathways is Factors involved in megakaryocyte development and platelet production. Related mouse phenotype reproductive system.

Related Diseases for Splenic Sequestration

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Diseases related to Splenic Sequestration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease10.9
2sickle cell anemia10.6
3thalassemia10.5
4hemoglobin c disease10.4
5thrombocytopenia10.4
6splenic infarction10.4
7hereditary spherocytosis10.4
8hepatitis10.3
9leukemia10.3
10hypersplenism10.3
11splenomegaly10.3
12deficiency anemia10.1
13chronic lymphocytic leukemia10.1
14hemolytic anemia10.1
15hemoglobinopathy10.1
16peritonitis10.1
17schistosomiasis10.1
18splenic disease10.1
19sickle beta thalassemia10.1
20hemoglobin e - beta-thalassemia10.1
21splenic manifestation of leukemia10.1HBB, THPO
22hypotrichosis-deafness syndrome10.1HBB, HBD
23skin pilomatrix carcinoma10.1HBB, HBD
24fetal hemoglobin quantitative trait locus 110.1HBB, HBD
25malignant teratoma10.1HBB, HBD
26brucella melitensis brucellosis10.1HBB, HBD
27mediastinum neurofibroma10.0HBB, HBD
28mediastinum rhabdomyosarcoma10.0HBB, HBD
29large cell carcinoma with rhabdoid phenotype10.0HBB, HBD
30hepatocellular adenoma10.0HBB, HBD
31urinary tract non-invasive transitional cell neoplasm10.0HBB, HBD
32goiter10.0HBB, HBD
33polyneuropathy10.0HBB, THPO
34avoidant personality disorder10.0HBB, HBD
35diffuse cutaneous mastocytosis10.0HBB, HBD
36congenital hypoplastic anemia10.0ANK1, HBB
37hemoglobinuria10.0HBB, HBD
38protoporphyria, erythropoietic, x-linked10.0HBB, HBD
39paratesticular lipoma10.0HBB, HBD
40hemoglobin h disease, nondeletional10.0HBB, HBD
41thalassemia, hispanic gamma-delta-beta10.0HBB, HBD
42presbyopia10.0ANK1, HBB
43hemophagocytic lymphohistiocytosis10.0ANK1, HBB
44tendinitis9.9HBB, THPO
45thromboangiitis obliterans9.9HBB, HBD
46snyder-robinson syndrome9.7BCAM, HBB, HBD
47proliferative fasciitis9.2ANK1, BCAM, GBA2, HBB, HBD, THPO

Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to splenic sequestration

Symptoms for Splenic Sequestration

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Drugs & Therapeutics for Splenic Sequestration

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Drugs for Splenic Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DesogestrelapprovedPhase 46954024-22-540973
Synonyms:
(17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol
13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol
13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
54024-22-5
AC-308
AC1L24T4
AC1Q282A
C07629
C22H30O
CHEBI:4453
CHEMBL1533
CID40973
Cerazette
D017135
D02367
 
DB00304
DESOGESTREL
Desogestrel (USAN/INN)
Desogestrel [USAN:BAN:INN]
Desogestrelum
Desogestrelum [INN-Latin]
EINECS 258-929-4
HSDB 3593
LMST02030104
LS-62079
MolPort-003-846-424
NCGC00167449-01
ORG 2969
Org-2969
Org2969
Organon Brand of Desogestrel
UNII-81K9V7M3A3
ZINC04097416
alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17
desogen
2ProgestinsPhase 4408
3
EthylenePhase 42674-85-16325
Synonyms:
Acetene
Athylen
Bicarburretted hydrogen
Elayl
Ethene
Ethene (9CI)
Ethene, 9CI
Ethylene (8CI)
 
Ethylene, compressed [UN1962] [Flammable gas]
Ethylene, pure
Ethylene-CMPD
Etileno
Liquid ethyene
Liquid ethylene
Olefiant gas
Plastipore
Polyethylene as med mol. WT.
43-keto-desogestrelPhase 466
5
HydroxyureaapprovedPhase 2181127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase

Interventional clinical trials:

idNameStatusNCT IDPhase
1Contraception in Women With Sickle Cell DiseaseRecruitingNCT02594462Phase 4
2Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesActive, not recruitingNCT01895361Phase 2
3The Spleen in Sickle Cell Anemia and Sickle Cell ThalassemiaCompletedNCT00971698
4Prognostic Factors of Acute Splenic SequestrationActive, not recruitingNCT01207037

Search NIH Clinical Center for Splenic Sequestration

Genetic Tests for Splenic Sequestration

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Anatomical Context for Splenic Sequestration

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Animal Models for Splenic Sequestration or affiliated genes

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MGI Mouse Phenotypes related to Splenic Sequestration:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2ANK1, BCAM, GBA2, HBB

Publications for Splenic Sequestration

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Articles related to Splenic Sequestration:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. (23657515)
2013
2
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. (22224796)
2012
3
Acute splenic sequestration crisis in an adult with sickle cell anaemia. (22411649)
2012
4
Elevated IL-1I+ and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. (22674409)
2012
5
Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration. (23304579)
2012
6
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. (21185577)
2011
7
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
8
Acute splenic sequestration in children with sickle cell anemia. (19668914)
2009
9
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. (19418550)
2009
10
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. (19944213)
2009
11
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. (18084762)
2008
12
Determination of hemolytic anemia through the study of (51)Cr red cell survival and splenic sequestration. (18483142)
2008
13
Acute splenic sequestration crisis in adults with sickle cell anemia. (16924644)
2007
14
Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. (16463155)
2006
15
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. (15108841)
2004
16
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. (17264555)
2001
17
Laparoscopic splenectomy for splenic sequestration crisis. (10806537)
2000
18
Aplastic crisis and acute splenic sequestration crisis. (10779041)
2000
19
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. (8615389)
1996
20
Splenectomy and acute splenic sequestration crises in sickle cell disease. (24057466)
1996
21
Acute splenic sequestration in the absence of palpable splenomegaly. (8166373)
1994
22
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. (8463907)
1993
23
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. (1731518)
1992
24
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. (1491841)
1992
25
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. (1585908)
1992
26
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. (1564621)
1992
27
Hematologic improvement in a patient with Gaucher disease on long-term enzyme replacement therapy: evidence for decreased splenic sequestration and improved red blood cell survival. (1951303)
1991
28
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia. (2025582)
1991
29
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. (1962525)
1991
30
Massive splenic infarction in doubly abnormal heterozygous sickling disorders. A new complication of acute splenic sequestration syndrome. (1815406)
1991
31
Management of acute splenic sequestration crisis in sickle cell disease. (2136619)
1990
32
Recurrent acute splenic sequestration crisis due to interacting genetic defects: hemoglobin SC disease and hereditary spherocytosis. (2294990)
1990
33
Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT, and MR imaging findings. (2243976)
1990
34
Acute splenic sequestration crises in Saudi children with sickle cell disease. (2473699)
1989
35
Acute splenic sequestration in siblings with sickle cell disease. (2456724)
1988
36
Acute splenic sequestration in sickle cell disease. (3712147)
1986
37
Acute splenic sequestration crises in adults with sickle cell disease. (3706382)
1986
38
Acute splenic sequestration in a child with beta +-thalassaemia intermedia. (6404701)
1983
39
Evidence for splenic sequestration of in vivo labeled erythrocytes. (7273547)
1981
40
Splenic sequestration of 99mTc labeled, heat treated red blood cells. (7403531)
1980
41
Acute splenic sequestration in hemoglobin sickle O-Arab disease. (7382253)
1980
42
Evidence for splenic sequestration of in vivo-labeled erythrocytes. (7438636)
1980
43
Splenic sequestration with sickle cell-C disease. (626559)
1978
44
Splenic sequestration syndrome in sickle/hemoglobin C disease at low altitude. (874706)
1977
45
Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes. (1201241)
1975
46
(51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy. (4524870)
1974
47
Red cells life span, splenic sequestration and transfusion requirements in chronic renal failure treated by hemodialysis. Effects of bilateral nephrectomy. (4823492)
1974
48
Splenic sequestration of young erythrocytes in sheep. (4686481)
1973
49
Splenic sequestration of 99m Tc-labeled red blood cells. (5080014)
1972
50
Splenic sequestration of stress erythrocytes in the rabbit. (5414022)
1970

Variations for Splenic Sequestration

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Expression for genes affiliated with Splenic Sequestration

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Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for genes affiliated with Splenic Sequestration

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Pathways related to Splenic Sequestration according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HBB, HBD

GO Terms for genes affiliated with Splenic Sequestration

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Cellular components related to Splenic Sequestration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:00058339.7HBB, HBD
2blood microparticleGO:00725629.4HBB, HBD

Biological processes related to Splenic Sequestration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:00156719.9HBB, HBD
2blood coagulationGO:00075969.0HBB, HBD, THPO

Molecular functions related to Splenic Sequestration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:00053449.9HBB, HBD
2iron ion bindingGO:00055069.5HBB, HBD
3oxygen bindingGO:00198259.5HBB, HBD
4heme bindingGO:00200379.4HBB, HBD

Sources for Splenic Sequestration

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet