Splenomegaly malady

Wikipedia: Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)...⁴⁴ more...

MalaCards: Splenomegaly is related to hypersplenism and myelofibrosis. An important gene associated with Splenomegaly is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Graft-versus-host disease and RIG-I-like receptor signaling pathway. The compounds anagrelide and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include lung, spleen and bone marrow, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

splenomegaly 30 32

Diseases related to splenomegaly by text searches and GeneDecks gene sharing:

(show top 50)    (show all 597)

id	Related Disease	Score	Top Affiliating Genes
1	hypersplenism	30.7	THPO, CSF3, EPO, GBA
2	myelofibrosis	29.5	JAK2, THPO, EPO
3	gaucher's disease	29.2	CHIT1, SMPD1, HBB, TKT, GBA
4	hereditary spherocytosis	29.0	HBA2, HBB
5	essential thrombocythemia	28.2	MPL, JAK2, THPO
6	sea-blue histiocytosis	28.1	LCAT, SMPD1
7	typhoid fever	28.1	GPT, HLA-DQB1, HLA-DRB1, SLC17A5
8	prolidase deficiency	27.9	SLC17A5, PEPD
9	pancytopenia	27.3	MPL, ITK, IL2RA, HP, THPO, CSF3
10	infectious mononucleosis	27.1	IL10, GPT, IFNA1, HP, HLA-DRB1, SLC17A5
11	polycythemia vera	26.9	MPL, JAK2, ITGB2, IFNA1, IFNA2, TET2
12	lymphoproliferative syndrome	26.7	ATM, JAK2, CD5, ITGAX, IL2RA, FASLG
13	autoimmune hemolytic anemia	26.6	IL10, IL2RA, IFNA1, IFNA2, HP
14	lymphoblastic lymphoma	26.6	ATM, FASLG, FAS, ENO2, CSF3, RUNX1
15	myelodysplastic syndrome	26.4	MPL, JAK2, FASLG, FAS, THPO, CSF3
16	histiocytosis	25.9	LCAT, JAK2, ITGAX, IL10, GPT, IFNA1
17	chronic myeloid leukemia	25.8	MPL, JAK2, ITGB2, IFNA1, IFNA2, TKT
18	thrombocytosis	25.6	VEGFA, MPL, JAK2, IFNA1, IFNA2, HP
19	common variable immunodeficiency	25.5	IL10, IL2RA, FAS, HLA-DQB1, HLA-DRB1
20	thrombocytopenia	24.5	CHIT1, MPL, CD5, ITGB2, ITK, IL10
21	polycythemia	24.5	VEGFA, MPL, JAK2, ITGB2, FASLG, FAS
22	sarcoidosis	22.7	VEGFA, CHIT1, GRP, IL10, IL2RA, FASLG
23	nephropathy	20.7	VEGFA, LCAT, JAK2, ITGB2, IL10, IL2RA
24	cholesterol	20.5	VEGFA, LIPA, LCAT, JAK2, ITGAX, ITGB2
25	myeloid leukemia	19.7	VEGFA, CHIT1, ATM, MPL, JAK2, ITGAX
26	fibrosis	19.0	VEGFA, LCAT, ATM, MPL, JAK2, GRP
27	tuberculosis	18.0	VEGFA, BPGM, LIPA, CHIT1, JAK2, CD5
28	leukemia	15.1	VEGFA, CHIT1, LCAT, ATM, MPL, JAK2
29	gaucher disease type 3	13.8	CHIT1, GBA
30	gaucher disease type 1	13.8	CHIT1, GBA
31	hemorrhagic thrombocythemia	13.7	MPL, JAK2, THPO
32	severe congenital neutropenia	13.7	JAK2, THPO, CSF3
33	hypoalphalipoproteinemia	13.7	LCAT, ABCA1, GBA
34	niemann–pick disease	13.7	CHIT1, LCAT, SMPD1
35	granulomatous hepatitis	13.7	IFNA1, IFNA2
36	congenital amegakaryocytic thrombocytopenia	13.7	MPL, THPO
37	neonatal anemia	13.7	HBA2, EPO
38	obstructive jaundice	13.6	LCAT, GPT, SLC17A5
39	acquired polycythemia	13.6	JAK2, EPO
40	sm-ahnmd	13.6	JAK2, IL2RA, IFNA2
41	hepatitis	13.6	GPT, IFNA1, SLC17A5
42	acute liver failure	13.6	GPT, THPO, SLC17A5
43	lysosomal storage disease	13.6	LIPA, CHIT1, SMPD1, GBA
44	hepatitis d	13.6	GPT, IFNA1, IFNA2
45	pyomyositis	13.6	GPT, CSF3
46	creatine phosphokinase	13.6	GPT, SLPI, SLC17A5
47	hemoglobin constant spring	13.6	HBA2, HBB
48	pyridoxine deficiency	13.5	GPT, SLC17A5
49	lymphomatoid granulomatosis	13.5	IFNA1, IFNA2
50	portal hypertension	13.5	GPT, THPO, SLC17A5

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to splenomegaly:

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MGI Mouse Phenotypes related to splenomegaly:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.5	FASLG, TKT, SEC23B, CASP8
2	respiratory system phenotype	MP:0005388	9.1	GBA, GATA1, ABCA1, SMPD1, APOE, LIPA
3	renal/urinary system phenotype	MP:0005367	8.9	HBB, ABCA1, TET2, APOE, TKT, LIPA
4	nervous system phenotype	MP:0003631	8.6	FASLG, LIPA, CASP8, HLA-DQB1, GBA, KRT19
5	hematopoietic system phenotype	MP:0005397	8.3	GATA1, EPO, RUNX1, CSF3, THPO, TET2
6	digestive/alimentary phenotype	MP:0005381	8.3	VEGFA, LIPA, APOE, SEC23B, KRT19, ABCA1
7	integument phenotype	MP:0010771	8.2	HBB, HBA2, KRT19, CASP8, FAS, LIPA
8	liver/biliary system phenotype	MP:0005370	8.1	GBA, EPO, RUNX1, HBB, ABCA1, SMPD1
9	tumorigenesis	MP:0002006	8.1	JAK2, IL10, ATM, RUNX1, FASLG, HP
10	skeleton phenotype	MP:0005390	8.0	GATA1, ITGB2, HBB, RUNX1, JAK2, VEGFA
11	reproductive system phenotype	MP:0005389	7.7	VEGFA, IL10, FASLG, SMPD1, KRT19, HBB
12	immune system phenotype	MP:0005387	7.7	ATM, TET2, SMPD1, ABCA1, HBB, RUNX1
13	growth/size phenotype	MP:0005378	6.6	TRAF2, FAS, APOE, IL2RA, JAK2, MPL
14	normal phenotype	MP:0002873	6.4	EPO, VEGFA, HBB, KRT19, TET2, FASLG
15	homeostasis/metabolism phenotype	MP:0005376	5.5	FASLG, VEGFA, LIPA, LCAT, MPL, JAK2
16	mortality/aging	MP:0010768	5.5	HP, APOE, IL2RA, ITGB2, JAK2, MPL
17	cardiovascular system phenotype	MP:0005385	5.1	HBB, IL10, ITGB2, TET2, HLA-DQB1, CASP8
18	cellular phenotype	MP:0005384	3.9	VEGFA, ATM, MPL, JAK2, CD5, ITGAX

Articles related to splenomegaly:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Hereditary thrombocytosis caused by MPLSer505Asn is a ssociated with a high thrombotic risk, splenomegaly and progression to bone mar row fibrosis. (19713221)	Teofili L.... Larocca L.M.	2010	MPL
2	How I treat symptomatic splenomegaly in patients with myelofibrosis. (19332765)	Mesa R.A.	2009	JAK2
3	A case of tuberculosis with multiple lung nodules, a bdominal lymphadenopathy, and splenomegaly (19928550)	Horie M.... Nakajima Y.	2009	KRT19, GRP
4	Splenomegaly with sea-blue histiocytosis, dyslipidemi a, and nephropathy in a patient with lecithin-cholesterol acyltransferase defic iency: a clinicopathologic correlation. (19592052)	Naghashpour M.... Cualing H.	2009	LCAT
5	Voluminous nodular splenomegaly in Gaucher disease: a case report (19375198)	RozAc B.... Hutin P.	2009	GBA
6	Thrombocytopenia in association with splenomegaly during granulocyte-colony-stimulating factor treatment in mice is not caused by hypersplenism and is resolved spontaneously. (17207228)	Takamatsu Y.... Tamura K.	2007	CSF3
7	JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. (17712047)	Barosi G.... Barbui T.	2007	JAK2
8	HLA-DQB1 0602 allele is associated with splenomegaly in Japanese sarcoidosis. (17875181)	Sato H.... Izumi T.	2007	HLA-DQB1, HLA-DRB1
9	AML1 deletion in adult mice causes splenomegaly and lymphomas. (16247465)	Putz G.... Buchholz F.	2006	RUNX1
10	Elevated plasma levels of vascular endothelial growth factor is associated with marked splenomegaly in chronic myeloid leukemia. (16263579)	Liu P.... Peng Z.	2005	VEGFA
11	NSE-positive lymphoblastic lymphoma in a boy with cu taneous involvement, giant splenomegaly, and hyper-gamma globulinemia (15678916)	Takahashi K.... Nakazawa S.	2004	ENO2
12	Urothelial cancer producing granulocyte colony-stimulating factor: possible induction of splenomegaly. (14972497)	Kitayama S.... Kihara K.	2004	CSF3
13	A 32-year old male patient with pathological humeral fracture, splenomegaly and thrombocytopenia (15151139)	DA1rr E.M.... Parhofer K.G.	2004	GBA
14	Increased serum levels of vascular endothelial growth factor correlate with splenomegaly in polycythemia vera. (12363469)	Murphy P.... Hassan H.T.	2002	EPO
15	Splenomegaly induced by recombinant human granulocyte-colony stimulating factor in rats. (11554613)	Nakayama T.... Sakamoto S.	2001	TYMS, TKT
16	Murine gammaherpesvirus-68-induced interleukin-10 increases viral burden, but limits virus-induced splenomegaly and leukocytosis. (11576228)	Peacock J.W.... Bost K.L.	2001	IL10
17	Improvement of splenomegaly and pancytopenia by enzym e replacement therapy against type 1 Gaucher disease: a report of sibling cases . (11345203)	Tsuboi K.... Ueda R.	2001	GBA
18	Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)]. (11095479)	Nguyen T.T.... O'Brien T.	2000	APOE, LCAT
19	A female patient with splenomegaly, interstitial pneumopathy and giant foam cells in bone marrow (10515006)	Imhof A.... Streuli R.A.	1999	SMPD1
20	Rapid aggravation of splenomegaly by administration of erythropoietin in a case of myelodysplastic syndrome (1479699)	Sato T.... Chiba S.	1992	EPO
21	Usefulness of the immunologic phenotype in the diagnosis of chronic lymphoproliferative syndromes with splenomegaly as the dominant clinical manifestation (2291146)	Silva Rodrigues A.... Lopez Borrasca A.	1990	CD5

Genes related to splenomegaly according to GeneCards:

(show all 45)

id	Symbol	Description	Score	GeneCards Section Context
1	CHIT1	chitinase 1 (chitotriosidase)	11.0
2	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
3	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
4	GBA	glucosidase, beta, acid	11.0	Publications
5	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	11.0
6	LIPA	lipase A, lysosomal acid, cholesterol esterase	11.0
7	HBA2	hemoglobin, alpha 2	11.0
8	JAK2	Janus kinase 2	11.0	Publications
9	TRAF2	TNF receptor-associated factor 2	11.0
10	THPO	thrombopoietin	11.0
11	HP	haptoglobin	11.0
12	PEPD	peptidase D	11.0
13	SLPI	secretory leukocyte peptidase inhibitor	11.0
14	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0
15	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	11.0
16	EPO	erythropoietin	11.0	Publications
17	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0
18	IFNA1	interferon, alpha 1	11.0
19	IFNA2	interferon, alpha 2	11.0
20	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0
21	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
22	FAS	Fas (TNF receptor superfamily, member 6)	11.0
23	IL2RA	interleukin 2 receptor, alpha	11.0
24	BPGM	2,3-bisphosphoglycerate mutase	11.0
25	CD5	CD5 molecule	11.0	Publications
26	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11.0	Publications
27	ITK	IL2-inducible T-cell kinase	11.0
28	SEC23B	Sec23 homolog B (S. cerevisiae)	11.0
29	TET2	tet methylcytosine dioxygenase 2	11.0
30	GATA1	GATA binding protein 1 (globin transcription factor 1)	11.0
31	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
32	GRP	gastrin-releasing peptide	11.0	Publications
33	KRT19	keratin 19	11.0	Publications
34	CASP8	caspase 8, apoptosis-related cysteine peptidase	11.0
35	ATM	ataxia telangiectasia mutated	11.0
36	HBB	hemoglobin, beta	11.0
37	TKT	transketolase	11.0	Publications
38	FASLG	Fas ligand (TNF superfamily, member 6)	11.0
39	TYMS	thymidylate synthetase	11.0	Publications
40	RUNX1	runt-related transcription factor 1	11.0	Publications
41	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
42	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
43	APOE	apolipoprotein E	11.0	Publications
44	VEGFA	vascular endothelial growth factor A	11.0	Publications
45	IL10	interleukin 10	11.0	Publications

Pathways related to splenomegaly according to GeneDecks:

(show all 35)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.4	FASLG
2	RIG-I-like receptor signaling pathway20	10.3	CASP8
3	Development Thrombopoetin signaling via JAK-STAT pathway10	10.2	MPL, JAK2
4	Development_Thrombopoetin signaling via JAK-STAT pathway41	10.2	THPO, MPL, JAK2
5	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.1	FASLG, IL2RA
6	Molecular Mechanisms of Cancer36	9.9	ATM, ITGB2, ITGAX, CASP8
7	Apoptosis and survival Apoptotic TNF-family pathways10	9.9	FAS, CASP8, FASLG, TRAF2
8	Apoptosis and survival_Apoptotic TNF-family pathways41	9.9	FASLG, TRAF2, CASP8, FAS
9	Natural killer cell mediated cytotoxicity20	9.8	FASLG, IFNA2, IFNA1, FAS, ITGB2
10	Apoptosis Signaling Pathways37	9.8	FASLG, CASP8, FAS, TRAF2
11	Measles20	9.8	IFNA2, FAS, FASLG, JAK2, IL2RA, IFNA1
12	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	FAS, IL10, FASLG, IL2RA
13	Apoptosis20	9.7	ATM, FASLG, FAS, CASP8, TRAF2
14	Malaria20	9.6	IL10, HBA2, CSF3, HBB, ITGB2
15	Hematopoietic cell lineage20	9.6	HLA-DRB1, IL2RA, CD5, CSF3, EPO, THPO
16	Lymphocyte Signaling3	9.5	ITK, IL2RA, FASLG, GATA1, RUNX1
17	Immune response IL-22 signaling pathway10	9.5	HLA-DRB1, IL2RA, JAK2, HLA-DQB1
18	Tec Kinases Signaling36	9.4	THPO, IL10, IL2RA, ITK, JAK2, ITGB2
19	African trypanosomiasis20	9.4	FASLG, HBA2, FAS, IL10, HBB
20	Jak-STAT signaling pathway20	9.4	CSF3, EPO, IFNA1, IL2RA, IL10, JAK2
21	JAK-STAT Pathway36	9.4	THPO, EPO, IFNA1, IL2RA, JAK2, MPL
22	Immune response_IL-22 signaling pathway41	9.4	HLA-DQB1, HLA-DRB1, JAK2, IL2RA
23	Type I diabetes mellitus20	9.3	HLA-DRB1, HLA-DQB1, FAS, FASLG
24	Viral myocarditis20	9.2	HLA-DRB1, ITGB2, HLA-DQB1, CASP8
25	THC Differentiation Pathway36	9.1	IL10, IL2RA, HLA-DQB1, HLA-DRB1
26	Staphylococcus aureus infection20	9.1	IL10, ITGB2, HLA-DRB1, HLA-DQB1
27	ICos-ICosL Pathway in T-Helper Cell36	9.1	HLA-DQB1, IL2RA, HLA-DRB1, ITK
28	Leishmaniasis20	9.1	IL10, JAK2, ITGB2, HLA-DQB1, HLA-DRB1
29	Influenza A20	9.0	FASLG, JAK2, HLA-DRB1, IFNA2, IFNA1, HLA-DQB1
30	Toxoplasmosis20	8.9	CASP8, JAK2, HLA-DQB1, IL10, HLA-DRB1
31	Allograft rejection20	8.9	HLA-DRB1, HLA-DQB1, IL10, FAS, FASLG
32	CDC42 Pathway36	8.8	HLA-DRB1, ITK, HLA-DQB1, ITGB2, ITGAX
33	Autoimmune thyroid disease20	8.6	FASLG, FAS, IFNA1, IFNA2, HLA-DQB1, HLA-DRB1
34	Tuberculosis20	8.5	ITGAX, HLA-DRB1, HLA-DQB1, CASP8, IFNA2, IL10
35	Cytokine-cytokine receptor interaction20	8.2	EPO, CSF3, IFNA2, VEGFA, MPL, FASLG

Compounds related to splenomegaly according to GeneDecks:

(show top 50)    (show all 249)

id	Compound	Score	Top Affiliating Genes
1	anagrelide32 9 9	12.1	THPO, EPO, MPL, JAK2, IFNA1, IFNA2
2	hyaluronic acid32 18	10.5	ITGB2, FASLG, GPT, KRT19, THPO, SLPI
3	topotecan32 9 9	11.5	ATM, TYMS, TKT, CASP8
4	dmso32	9.4	GATA1, RUNX1, THPO, SLC17A5, HBB, SMPD1
5	rapamycin32 42	10.4	VEGFA, JAK2, ABCA1, TKT, THPO
6	lamivudine32 9 9	11.3	SLC17A5, IL2RA, SLPI, IFNA2, IFNA1, GPT
7	ribavirin32 34 9 9	12.2	SLC17A5, EPO, IL10, CSF3, HP, IFNA2
8	ascorbic acid32 18	10.0	IL2RA, JAK2, FASLG, EPO, SLC17A5, TKT
9	epinephrine32 9 18 9	12.0	SLC17A5, GRP, FASLG, FAS, CASP8, HP
10	estrogen32	9.0	KRT19, HP, APOE, GRP, LCAT, HBB
11	glutamate32	8.9	TYMS, PEPD, ABCA1, GRP, JAK2, LCAT
12	mitomycin c32	8.9	ATM, FASLG, FAS, CASP8, TYMS, TKT
13	aspirin32 34 18	10.9	IL2RA, JAK2, MPL, GRP, APOE, FAS
14	doxorubicin32 34 9 9	11.8	SMPD1, PEPD, GATA1, CASP8, IFNA2, FAS
15	prednisolone32 9 9	10.6	CSF3, ITGB2, RUNX1, IL10, IL2RA, GPT
16	zidovudine32 9 9	10.6	TKT, TYMS, IFNA2, IFNA1, GPT, IL10
17	oxygen32 18	9.6	SLC17A5, SLPI, THPO, HBB, SMPD1, CASP8
18	cytarabine32 34 9 9	11.5	GATA1, ATM, FASLG, FAS, IFNA1, IFNA2
19	ifn-alpha32	8.5	IFNA2, IFNA1, GPT, FAS, FASLG, IL2RA
20	cysteine32	8.4	MPL, CASP8, LIPA, LCAT, FASLG, SMPD1
21	etoposide32 42 9 9	11.4	IFNA2, CASP8, TKT, THPO, RUNX1, ENO2
22	carboplatin32 34 9 9	11.4	HP, CSF3, THPO, TYMS, EPO, VEGFA
23	aspartate32	8.4	FASLG, HP, HLA-DQB1, SMPD1, KRT19, HBB
24	leucovorin32 34 9 9	11.3	CSF3, FASLG, THPO, TKT, TYMS, IFNA2
25	hydroxyurea32 9 9	10.3	GATA1, EPO, CSF3, THPO, ATM, JAK2
26	iron32 18	9.1	GPT, IFNA2, HP, KRT19, HBA2, HBB
27	cholesterol32 9 18 9	11.0	GPT, ENO2, FASLG, LCAT, APOE, HP
28	adenylate32	7.8	HP, HBB, TYMS, GBA, TKT, THPO
29	5fluorouracil32	7.7	MPL, CSF3, THPO, TKT, TYMS, CASP8
30	methotrexate32 34 42 9 9	11.7	GBA, HLA-DRB1, IL10, IL2RA, FASLG, ENO2
31	butyrate32	7.7	FASLG, ITGB2, ITGAX, JAK2, LCAT, CASP8
32	cyclosporin a32 42	8.6	JAK2, ITGB2, ITK, IL10, IL2RA, APOE
33	simvastatin32 34 42 9 18 9	12.6	ITGB2, LIPA, LCAT, VEGFA, ABCA1, SLC17A5
34	nitric oxide32 9 18 9	10.5	HBB, SLPI, FAS, GBA, SLC17A5, ATM
35	creatinine32	7.5	SLPI, SLC17A5, PEPD, EPO, TKT, THPO
36	testosterone32 9 18 9	10.5	GRP, LCAT, LIPA, IL2RA, APOE, FASLG
37	lactate32	7.5	ENO2, GPT, HP, KRT19, HBB, TYMS
38	atorvastatin32 34 9 18 9	11.5	IL10, ABCA1, SLC17A5, APOE, GPT, FASLG
39	imatinib32 34 9 9	10.5	VEGFA, EPO, RUNX1, CSF3, THPO, TKT
40	tamoxifen32 34 9 9	10.3	TKT, IFNA1, TYMS, IFNA2, VEGFA, FAS
41	vegf32	7.3	MPL, SLPI, RUNX1, EPO, GATA1, CSF3
42	retinoic acid32 42 18	9.2	THPO, ITGAX, ITGB2, SLPI, RUNX1, CSF3
43	dexamethasone32 42 34 9 9	11.0	VEGFA, FAS, IL2RA, IL10, GRP, JAK2
44	oligonucleotide32	6.8	ITGB2, FAS, HLA-DQB1, HLA-DRB1, LIPA, JAK2
45	thymidine32 18	7.8	IL2RA, FASLG, FAS, ENO2, IFNA1, IFNA2
46	alanine32	6.8	CASP8, HP, HLA-DRB1, TRAF2, HBA2, HBB
47	cisplatin32 34 9 9	9.2	FAS, SMPD1, KRT19, TYMS, TKT, CSF3
48	serine32	5.5	GATA1, ITGB2, GRP, FAS, IFNA1, ITK
49	cycloheximide32	5.5	FAS, IFNA1, CASP8, TRAF2, TKT, CSF3
50	tyrosine32	3.7	ABCA1, HLA-DQB1, HP, CASP8, IFNA2, KRT19

Cellular components related to splenomegaly according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	haptoglobin-hemoglobin complex	GO:031838	9.9	HP, HBB, HBA2
2	membrane raft	GO:045121	9.4	FAS, JAK2, CASP8, TRAF2, ABCA1
3	external side of plasma membrane	GO:009897	9.2	HLA-DRB1, FAS, FASLG, ITGAX, CD5
4	extracellular space	GO:005615	6.9	VEGFA, EPO, CSF3, THPO, SMPD1, HP

Biological processes related to splenomegaly according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell death	GO:010942	10.1	HBB, HBA2, HP
2	inflammatory cell apoptotic process	GO:006925	10.0	FASLG, FAS
3	termination of signal transduction	GO:023021	9.9	GBA, SMPD1
4	myeloid cell differentiation	GO:030099	9.8	THPO, RUNX1, TET2
5	activation of pro-apoptotic gene products	GO:008633	9.8	FAS, TRAF2, CASP8, FASLG
6	reverse cholesterol transport	GO:043691	9.8	APOE, LCAT, ABCA1
7	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.7	JAK2, TRAF2, CASP8, FASLG, FAS
8	response to lipopolysaccharide	GO:032496	9.6	CASP8, THPO, EPO, FAS, FASLG, JAK2
9	induction of apoptosis by extracellular signals	GO:008624	9.6	TRAF2, CD5, FASLG, FAS, CASP8
10	positive regulation of apoptotic process	GO:043065	9.4	FAS, FASLG, JAK2, ATM, SMPD1
11	blood coagulation	GO:007596	8.7	GATA1, HBB, IFNA2, ITGB2, ITGAX, JAK2
12	small molecule metabolic process	GO:044281	7.8	TKT, SMPD1, GPT, ENO2, APOE, LCAT

Molecular functions related to splenomegaly according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	haptoglobin binding	GO:031720	10.0	HBB, HBA2
2	apolipoprotein A-I binding	GO:034186	10.0	LCAT, ABCA1
3	tumor necrosis factor receptor binding	GO:005164	9.8	TRAF2, CASP8, FASLG
4	cytokine activity	GO:005125	8.4	VEGFA, IL10, FASLG, IFNA2, THPO, CSF3