MCID: SPL018
MIFTS: 37

Splenomegaly malady

Summaries for Splenomegaly

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63Wikipedia, 32MalaCards
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Wikipedia:63 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards: Splenomegaly is related to hypersplenism and myelofibrosis. An important gene associated with Splenomegaly is LCAT (lecithin-cholesterol acyltransferase), and among its related pathways are Malaria and Development Thrombopoetin signaling via JAK-STAT pathway. The compounds aspartate and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include spleen, bone marrow and bone, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Splenomegaly

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42NIH Rare Diseases, 44Novoseek, 25ICD10
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Related Diseases for Splenomegaly

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17GeneCards, 18GeneDecks
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Diseases related to Splenomegaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 428)
idRelated DiseaseScoreTop Affiliating Genes
1hypersplenism30.8THPO, GBA
2myelofibrosis30.5THPO, EPO, MPL
3hepatitis30.5GPT, IFNA2, THPO
4sarcoidosis30.5IL2RA, CHIT1
5pancytopenia30.5HP, GBA, IL2RA, THPO, EPO, CSF3
6thrombocytopenia30.5SLPI, THPO, GPT, GBA, MPL, CSF3
7malaria30.5HP, HBA2, CHIT1
8leukemia30.4MPL, EPO, IL2RA, CSF3, JAK2, ITGB2
9gaucher's disease30.2CHIT1, GBA
10polycythemia vera30.2JAK2, THPO, MPL, IFNA2, EPO
11liver cirrhosis30.2LCAT, GPT, THPO, IFNA2
12polycythemia30.1THPO, HBA2, EPO, JAK2, MPL
13hodgkin's lymphoma30.1JAK2, TRAF2, CSF3, IL2RA
14arthritis30.0ITGB2, HP
15tuberculosis30.0IL2RA, HP, ITGB2
16sickle cell disease30.0HBA2, EPO, HP
17hairy cell leukemia30.0ITGB2, IL2RA, IFNA2, ITGAX
18melanoma30.0PEPD, JAK2, TRAF2, IFNA2
19hemolytic anemia30.0HBA2, EPO, IFNA2, LCAT, HP
20neutropenia30.0THPO, IFNA2, CSF3, MPL, GPT, EPO
21sarcoma29.9THPO, HBA2, SLPI, JAK2, GBA
22eosinophilia29.9ITGB2, JAK2, IL2RA, IFNA2
23hepatitis c29.9GPT, THPO, HP, IFNA2
24hepatitis b29.9IL2RA, GPT, IFNA2, SLPI
25thrombocytosis29.9EPO, CSF3, IFNA2, MPL, HP, JAK2
26purpura29.8THPO
27acute pancreatitis29.8GPT
28colorectal cancer29.8IFNA2
29autoimmune hemolytic anemia29.8HP
30beta thalassemia29.8EPO, HBA2
31systemic mastocytosis29.8IFNA2, IL2RA, JAK2
32rheumatoid arthritis29.8JAK2, THPO, IL2RA, HP, ITGB2
33acute leukemia29.8JAK2, MPL, EPO, ITGAX, HBA2, CSF3
34deficiency anemia29.8MPL, EPO, HP, HBA2, GBA, THPO
35kaposi's sarcoma29.6HBA2
36disseminated intravascular coagulation29.6THPO
37peritonitis29.6ITGB2, SLPI
38pneumonia29.6SLPI, CSF3
39gaucher disease type 129.6GBA, CHIT1
40alpha thalassemia29.6CHIT1, EPO, HBA2
41hemorrhagic thrombocythemia29.6MPL, JAK2, THPO
42iron deficiency anemia29.6EPO, THPO
43cholelithiasis29.6GPT
44adenocarcinoma29.6JAK2, ITGB2, PEPD
45vasculitis29.6PEPD, IFNA2, ITGB2, ITGAX
46cystic fibrosis29.6SLPI, ABCA1, PEPD, HP
47myeloid leukemia29.6CSF3, MPL, THPO, ITGB2, JAK2
48colon cancer29.6TRAF2, JAK2
49non-hodgkin lymphoma29.6CSF3, JAK2, ITGAX, IL2RA
50diabetes mellitus29.6ITGB2, LCAT, GPT, HP, ABCA1, HBA2

Graphical network of the top 20 diseases related to Splenomegaly:



Diseases related to splenomegaly

Clinical Features for Splenomegaly

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Drugs & Therapeutics for Splenomegaly

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Splenomegaly

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Anatomical Context for Splenomegaly

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32MalaCards
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MalaCards organs/tissues related to Splenomegaly:

32
Spleen, Bone marrow, Bone

Animal Models for Splenomegaly or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Splenomegaly:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.9ITGB2, LIPA, GBA
2MP:00053709.9ABCA1, GBA, HP, EPO, LIPA, LCAT
3MP:00053769.2LIPA, MPL, ITGB2, JAK2, LCAT, TRAF2
4MP:00053849.1JAK2, ITGB2, ITGAX, MPL, TRAF2, EPO
5MP:00107689.0TRAF2, LIPA, MPL, ITGB2, JAK2, EPO
6MP:00053879.0LIPA, MPL, ITGAX, ITGB2, JAK2, CSF3
7MP:00053978.8SLPI, LCAT, CSF3, JAK2, ITGB2, ITGAX

Publications for Splenomegaly

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Genetic Variations for Splenomegaly

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Expression for genes affiliated with Splenomegaly

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Splenomegaly

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Pathways for genes affiliated with Splenomegaly

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29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 52R&D Systems
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Pathways related to Splenomegaly according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4HBA2
2
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.2THPO, MPL, JAK2
3
Hide members
10.1EPO, ITGB2, JAK2
410.0IFNA2, JAK2, ITGB2, ITGAX
5
Hide members
10.0EPO, ITGAX, ITGB2, JAK2
6
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10.0CSF3, JAK2, MPL, IL2RA
710.0CSF3, EPO, IL2RA, THPO
8
Hide members
9.9IFNA2, JAK2, ITGB2, ITGAX, MPL
9
Hide members
9.9JAK2, MPL, TRAF2, IL2RA, THPO
109.9IFNA2, CSF3, JAK2, EPO, IL2RA
11
Hide members
9.8THPO, IL2RA, TRAF2, MPL, ITGAX, ITGB2
129.8IFNA2, CSF3, JAK2, MPL, EPO, IL2RA
13
Hide members
9.6CSF3, JAK2, ITGB2, ITGAX, TRAF2, IL2RA
14
Hide members
9.6CSF3, JAK2, ITGB2, ITGAX, TRAF2, IL2RA

Compounds for genes affiliated with Splenomegaly

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Splenomegaly according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1aspartate4410.5JAK2, GPT, ITGB2
2prednisolone44 28 1112.4ITGB2, PEPD, IFNA2, IL2RA
3lamivudine44 1111.4IL2RA, SLPI
4alpha tocopherol4410.4IFNA2, LCAT, IL2RA
5dexamethasone44 49 28 1113.4ABCA1, ITGB2, LCAT, SLPI
6anagrelide44 1111.4EPO, THPO, JAK2, IFNA2, MPL
7butyrate4410.4JAK2, THPO, HBA2, LCAT, ITGAX
8filgrastim44 1111.3IFNA2, EPO, CSF3, THPO
9phorbol 12,13-dibutyrate4410.3ITGB2, JAK2, THPO, IL2RA
10cellulose acetate4410.3HP, ITGB2, HBA2, SLPI
11miglustat44 1111.3IFNA2, GBA, CHIT1
12neopterin4410.3CHIT1, HP, GPT, IFNA2, IL2RA
13ribavirin44 49 1112.2EPO, CSF3, GPT, HP, IFNA2
14carboplatin44 49 1112.2HP, EPO, CSF3, THPO, IFNA2
15malondialdehyde4410.2EPO, SLPI, GPT, IL2RA, HP
16con a4410.2ITGB2, HP, IFNA2, IL2RA
17cholesterol ester4410.2LIPA, ABCA1, HP, LCAT
18glucose4410.2IFNA2, TRAF2, GBA, ABCA1, SLPI, PEPD
19hydroxyurea44 49 1112.2JAK2, CSF3, IFNA2, HBA2, THPO, EPO
20vitamin-e4410.2IFNA2, JAK2, HP, IL2RA, GPT, ABCA1
21rantes4410.2CSF3, SLPI, IL2RA, ITGB2, THPO
22hyaluronic acid44 2411.2HP, THPO, SLPI, ITGB2, PEPD, GPT
23azathioprine44 49 2 1113.1IL2RA, IFNA2, EPO, SLPI, GPT
24gp 1304410.1CSF3, JAK2, THPO, MPL, EPO, HP
25methionine4410.1PEPD, HP, ABCA1, SLPI, LCAT, HBA2
26aspirin44 49 28 2413.1PEPD, THPO, ABCA1, IL2RA, GBA, MPL
27ascorbic acid44 2411.1EPO, HP, LCAT, IFNA2, JAK2, SLPI
28oxygen44 2411.0SLPI, GBA, JAK2, ITGAX, HBA2, ABCA1
29phospholipid4410.0GBA, HP, LIPA, JAK2, LCAT, IL2RA
30lysine4410.0THPO, ABCA1, IL2RA, MPL, ITGB2, LCAT
31epinephrine44 11 2412.0IL2RA, JAK2, HP, CSF3, IFNA2, THPO
32adenylate4410.0GBA, THPO, GPT, ITGB2, LIPA, HBA2
33fibrinogen4410.0SLPI, ABCA1, GPT, HP, ITGAX, ITGB2
34superoxide44 2411.0THPO, IFNA2, CSF3, ITGAX, SLPI, PEPD
35creatinine449.9IL2RA, ITGB2, EPO, SLPI, PEPD, HP
36iron44 2410.9EPO, THPO, HBA2, CHIT1, MPL, IFNA2
37steroid449.9IFNA2, JAK2, LIPA, HP, SLPI, GBA
38polysaccharide449.9THPO, IL2RA, GBA, CHIT1, ITGB2, HP
39cyclosporin a44 28 5911.8ABCA1, GPT, IL2RA, HP, EPO, ITGB2
40cholesterol44 28 11 2412.8LCAT, JAK2, ITGB2, HP, GBA, GPT
41thymidine44 2410.8THPO, IL2RA, GBA, HBA2, SLPI, PEPD
42cysteine449.8HP, LIPA, MPL, SLPI, THPO, IL2RA
43cisplatin44 49 59 1112.7CSF3, JAK2, TRAF2, IFNA2, IL2RA, SLPI
44vegf449.7JAK2, THPO, IL2RA, HP, IFNA2, EPO
45heparin44 28 11 2412.7SLPI, HP, THPO, IL2RA, ITGB2, LCAT
46lipid449.7ABCA1, LIPA, CHIT1, TRAF2, ITGB2, JAK2
47alanine449.6PEPD, LCAT, IFNA2, JAK2, ITGB2, MPL
48phosphatidylinositol449.6THPO, ABCA1, IL2RA, EPO, TRAF2, MPL
49tyrosine449.3JAK2, IFNA2, ITGB2, SLPI, THPO, ABCA1
50nitric oxide44 11 2411.3JAK2, ITGAX, SLPI, HP, GBA, ITGB2

GO Terms for genes affiliated with Splenomegaly

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16Gene Ontology
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Cellular components related to Splenomegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:03183810.3HP, HBA2
2extracellular spaceGO:0056159.4THPO, HP, EPO, CHIT1, CSF3, IFNA2

Biological processes related to Splenomegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:0069159.8JAK2, ITGB2, TRAF2, EPO, IL2RA, IFNA2
2blood coagulationGO:0075969.5THPO, MPL, ITGAX, ITGB2, JAK2, IFNA2

Molecular functions related to Splenomegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I bindingGO:03418610.3ABCA1, LCAT

Products for genes affiliated with Splenomegaly

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Splenomegaly

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet