MCID: SPL018
MIFTS: 50

Splenomegaly malady

Summaries for Splenomegaly

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64Wikipedia, 33MalaCards
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Wikipedia:64 Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

MalaCards: Splenomegaly is related to hypersplenism and gaucher's disease. An important gene associated with Splenomegaly is LCAT (lecithin-cholesterol acyltransferase), and among its related pathways are Malaria and Development Thrombopoetin signaling via JAK-STAT pathway. The compounds aspartate and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Splenomegaly

Sources:
43NIH Rare Diseases, 45Novoseek, 25ICD10
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Related Diseases for Splenomegaly

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Splenomegaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 425)
idRelated DiseaseScoreTop Affiliating Genes
1hypersplenism30.8THPO, GBA
2gaucher's disease30.5CHIT1, GBA
3pancytopenia30.5HP, GBA, IL2RA, THPO, EPO, CSF3
4thrombocytopenia30.5SLPI, THPO, GPT, GBA, MPL, CSF3
5hepatitis c30.3GPT, THPO, HP, IFNA2
6polycythemia vera30.3JAK2, THPO, MPL, IFNA2, EPO
7arthritis30.1ITGB2, HP
8tuberculosis30.1IL2RA, HP, ITGB2
9sickle cell disease30.1HBA2, EPO, HP
10niemann–pick disease30.0CHIT1, LCAT
11thrombocytosis30.0EPO, CSF3, IFNA2, MPL, HP, JAK2
12acute pancreatitis29.9GPT
13colorectal cancer29.9IFNA2
14autoimmune hemolytic anemia29.9HP
15thalassemia29.9CHIT1, EPO, HBA2
16beta thalassemia29.8EPO, HBA2
17systemic mastocytosis29.8IFNA2, IL2RA, JAK2
18leukopenia29.8CSF3, GPT, IFNA2
19refractory anemia29.8JAK2, THPO, MPL, EPO, CSF3
20myeloproliferative disorder29.8JAK2, CSF3, EPO, THPO, IFNA2, MPL
21acute leukemia29.8JAK2, MPL, EPO, ITGAX, HBA2, CSF3
22kawasaki disease29.6GPT
23hypereosinophilic syndrome29.6IL2RA
24mastocytosis29.6IL2RA, IFNA2
25iron deficiency anemia29.6EPO, THPO
26cholelithiasis29.6GPT
27hypertriglyceridemia29.6GPT, ABCA1, LCAT
28plasmodium falciparum malaria29.6CHIT1, HP, ITGB2
29adenocarcinoma29.6JAK2, ITGB2, PEPD
30vasculitis29.6PEPD, IFNA2, ITGB2, ITGAX
31cystic fibrosis29.6SLPI, ABCA1, PEPD, HP
32myelodysplastic syndromes29.6MPL, JAK2, EPO, CSF3, THPO
33hepatitis d29.6IFNA2, GPT
34chronic myeloid leukemia29.6THPO, MPL, ITGB2, JAK2, CSF3, IFNA2
35systemic lupus erythematosus29.6IL2RA, TRAF2, ITGB2, MPL
36burkitt's lymphoma29.6ITGAX, IL2RA, ITGB2, SLPI, TRAF2, CSF3
37deficiency anemia29.6MPL, EPO, HP, HBA2, GBA, THPO
38myeloid splenomegaly10.4
39felty's syndrome10.3
40portal hypertension10.3
41banti's syndrome10.3
42hepatitis a10.2
43visceral leishmaniasis10.2
44mantle cell lymphoma10.2
45chronic congestive splenomegaly10.1
46infectious mononucleosis10.1
47splenic disease10.1
48n syndrome10.1
49cystic lymphangioma10.1
50hepatitis c virus10.1

Graphical network of the top 20 diseases related to Splenomegaly:



Diseases related to splenomegaly

Clinical Features for Splenomegaly

Drugs & Therapeutics for Splenomegaly

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Splenomegaly

Drug clinical trials:

Search ClinicalTrials for Splenomegaly

Search NIH Clinical Center for Splenomegaly

Search CenterWatch for Splenomegaly

Genetic Tests for Splenomegaly

Anatomical Context for Splenomegaly

Sources:
33MalaCards
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MalaCards organs/tissues related to Splenomegaly:

33
Bone marrow, Lymph node, Spleen, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Skin, Uterus, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Tongue, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Splenomegaly or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Splenomegaly

Sources:
51PubMed
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Articles related to Splenomegaly:

(show top 50)    (show all 562)
idTitleAuthorsYear
1
An adult patient with respiratory failure and splenomegaly. (23850172)
2013
2
Refractory anemia with ring sideroblasts associated with marked thrombocytosis complicated by massive splenomegaly treated with lenalidomide resulting in resolution of splenomegaly but severe and prolonged pancytopenia. (23653870)
2013
3
A woman with ascites, nodular liver contour, and splenomegaly. (22819503)
2012
4
Splenomegaly and variceal bleeding in a ten-year-old HIV-infected girl with noncirrhotic portal hypertension. (22828640)
2012
5
Predictive factors for persistent splenomegaly and hypersplenism after adult living donor liver transplantation. (22483486)
2012
6
Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index. (21609366)
2011
7
The AMPKI^1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia. (20881209)
2011
8
Mantle cell lymphoma of the colon with massive splenomegaly: A case report. (22055598)
2011
9
The feasibility and safety of laparoscopic splenectomy for massive splenomegaly: a comparative study. (21885066)
2011
10
Klippel-Trenaunay syndrome complicated with splenomegaly. (22196636)
2011
11
Splenomegaly as risk factor of liver cirrhosis. A retrospective cohort study of 2,525 patients who underwent laparoscopy. (22021698)
2011
12
Detection of splenomegaly on Meckel's diverticulum scan. (19352291)
2009
13
How I treat symptomatic splenomegaly in patients with myelofibrosis. (19332765)
2009
14
Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann-Pick disease: an atypical hemangioma enhancement pattern. (23396497)
2009
15
Laparoscopic splenectomy for massive splenomegaly: technical aspects of initial ligation of splenic artery and extraction without hand-assisted technique. (18503372)
2008
16
Myeloproliferative disorder-associated massive splenomegaly. (18496494)
2008
17
Hyperreactive malarial splenomegaly in expatriates. (17161315)
2007
18
Thrombocytopenia in association with splenomegaly during granulocyte-colony-stimulating factor treatment in mice is not caused by hypersplenism and is resolved spontaneously. (17207228)
2007
19
Surgical treatment of massive splenomegaly and severe hypersplenism secondary to extrahepatic portal venous obstruction in children. (17186340)
2007
20
Redefining the role of splenectomy in patients with idiopathic splenomegaly. (16916382)
2006
21
Splenomegaly, anaemia and pleural effusion. (15632233)
2005
22
Determination of splenomegaly by CT: is there a place for a single measurement? (15855107)
2005
23
Conjugation of 3' hexameric deoxyriboguanosine run to phosphodiester CpG oligodeoxynucleotides can inhibit allergen-specific IgE synthesis with less risk of splenomegaly. (16337478)
2005
24
Cardiovascular effects of splenomegaly and splenectomy in beta-thalassemia. (15711802)
2005
25
Images of interest. Hepatobiliary and pancreatic: massive splenomegaly. (16336459)
2005
26
Tinospora cordifolia as an adjuvant drug in the treatment of hyper-reactive malarious splenomegaly--case reports. (15999460)
2005
27
Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa. (16326982)
2005
28
A 14-month-old boy with prolonged fever and splenomegaly. (15515351)
2004
29
Hemodynamic assessment of splenomegaly in beta-thalassemia patients undergoing splenectomy. (15338197)
2004
30
Frequency and etiology of splenomegaly in adults seeking medical advice in Combined Military Hospital Attock. (15762063)
2004
31
NSE-positive lymphoblastic lymphoma in a boy with cutaneous involvement, giant splenomegaly, and hyper-gamma globulinemia]. (15678916)
2004
32
A complication of transoesophageal echocardiography in a patient with splenomegaly. (14601292)
2003
33
A mysterious splenomegaly in a young Turkish patient. (12368178)
2002
34
Asymptomatic sarcoidosis presenting as massive splenomegaly. (12505126)
2002
35
Increased serum levels of vascular endothelial growth factor correlate with splenomegaly in polycythemia vera. (12363469)
2002
36
Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. (11139352)
2000
37
Rapid tumor formation and development of neutrophilia and splenomegaly in nude mice transplanted with human cells expressing human T cell leukemia virus type I or Tax1. (10942244)
2000
38
Circulating villous lymphocytes--a link between hyperreactive malarial splenomegaly and splenic lymphoma. (9196759)
1997
39
Splenomegaly as the first manifestation of thyroid cancer metastases. (9349322)
1997
40
Non-Hodgkin's lymphoma presenting with prominent splenomegaly--clinicopathologic diversity in relationship to immunophenotype. (9490091)
1997
41
Splenic marginal zone cell lymphoma: report of an indolent variant without massive splenomegaly presumably representing an early phase of the disease. (7821915)
1995
42
Treatment of hyperreactive malarial splenomegaly syndrome. (7910924)
1994
43
Reversible marked splenomegaly in pernicious anemia. (8214989)
1993
44
The fifth cause of splenomegaly?--Parvovirus B19. (1478012)
1992
45
Ectopic splenomegaly in Felty's syndrome. (2032427)
1991
46
Hyperreactive malarious splenomegaly. (1676441)
1991
47
An unusual cause of splenomegaly and pancytopenia (secondary hypersplenism). (13876552)
1962
48
The effects of methyl cellulose in rats with special reference to splenomegaly, anaemia and the problem of hypersplenism. (13775928)
1961
49
Congestive splenomegaly due to pancreatic cystadenoma. (14935391)
1952
50
The etiology of Banti's syndrome further support of the congestive splenomegaly hypothesis. (20257494)
1947

Genetic Variations for Splenomegaly

Expression for genes affiliated with Splenomegaly

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Splenomegaly

Search GEO for disease gene expression data for Splenomegaly.

Pathways for genes affiliated with Splenomegaly

Sources:
30KEGG, 12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 53R&D Systems
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Pathways related to Splenomegaly according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4HBA2
2
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.2MPL, THPO, JAK2
3
Hide members
10.1EPO, ITGB2, JAK2
410.0IFNA2, JAK2, ITGAX, ITGB2
5
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10.0EPO, ITGAX, ITGB2, JAK2
6
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10.0IL2RA, MPL, JAK2, CSF3
710.0THPO, IL2RA, EPO, CSF3
8
Hide members
9.9JAK2, ITGB2, MPL, ITGAX, IFNA2
9
Hide members
9.9JAK2, MPL, IL2RA, TRAF2, THPO
109.9IFNA2, CSF3, EPO, IL2RA, JAK2
11
Hide members
9.8ITGB2, ITGAX, MPL, TRAF2, IL2RA, THPO
129.8IFNA2, CSF3, JAK2, MPL, EPO, IL2RA
13
Hide members
9.6CSF3, JAK2, ITGB2, ITGAX, TRAF2, IL2RA
14
Hide members
9.6ITGAX, TRAF2, CSF3, THPO, ITGB2, JAK2

Compounds for genes affiliated with Splenomegaly

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Splenomegaly according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1aspartate4510.5JAK2, GPT, ITGB2
2prednisolone45 29 1112.4ITGB2, PEPD, IFNA2, IL2RA
3lamivudine45 1111.4IL2RA, SLPI
4alpha tocopherol4510.4IFNA2, LCAT, IL2RA
5dexamethasone45 50 29 1113.4ABCA1, ITGB2, LCAT, SLPI
6anagrelide45 1111.4EPO, THPO, JAK2, IFNA2, MPL
7butyrate4510.4JAK2, THPO, HBA2, LCAT, ITGAX
8filgrastim45 1111.3IFNA2, EPO, CSF3, THPO
9phorbol 12,13-dibutyrate4510.3ITGB2, JAK2, THPO, IL2RA
10cellulose acetate4510.3HP, ITGB2, HBA2, SLPI
11miglustat45 1111.3IFNA2, GBA, CHIT1
12neopterin4510.3CHIT1, HP, GPT, IFNA2, IL2RA
13ribavirin45 50 1112.2EPO, CSF3, GPT, HP, IFNA2
14carboplatin45 50 1112.2HP, EPO, CSF3, THPO, IFNA2
15malondialdehyde4510.2EPO, SLPI, GPT, IL2RA, HP
16con a4510.2ITGB2, HP, IFNA2, IL2RA
17cholesterol ester4510.2LIPA, ABCA1, HP, LCAT
18glucose4510.2IFNA2, TRAF2, GBA, ABCA1, SLPI, PEPD
19hydroxyurea45 50 1112.2JAK2, CSF3, IFNA2, HBA2, THPO, EPO
20vitamin-e4510.2IFNA2, JAK2, HP, IL2RA, GPT, ABCA1
21rantes4510.2CSF3, SLPI, IL2RA, ITGB2, THPO
22hyaluronic acid45 2411.2HP, THPO, SLPI, ITGB2, PEPD, GPT
23azathioprine45 50 2 1113.1IL2RA, IFNA2, EPO, SLPI, GPT
24gp 1304510.1CSF3, JAK2, THPO, MPL, EPO, HP
25methionine4510.1PEPD, HP, ABCA1, SLPI, LCAT, HBA2
26aspirin45 50 29 2413.1PEPD, THPO, ABCA1, IL2RA, GBA, MPL
27ascorbic acid45 2411.1EPO, HP, LCAT, IFNA2, JAK2, SLPI
28oxygen45 2411.0SLPI, GBA, JAK2, ITGAX, HBA2, ABCA1
29phospholipid4510.0GBA, HP, LIPA, JAK2, LCAT, IL2RA
30lysine4510.0THPO, ABCA1, IL2RA, MPL, ITGB2, LCAT
31epinephrine45 11 2412.0IL2RA, JAK2, HP, CSF3, IFNA2, THPO
32adenylate4510.0GBA, THPO, GPT, ITGB2, LIPA, HBA2
33fibrinogen4510.0SLPI, ABCA1, GPT, HP, ITGAX, ITGB2
34superoxide45 2411.0THPO, IFNA2, CSF3, ITGAX, SLPI, PEPD
35creatinine459.9IL2RA, ITGB2, EPO, SLPI, PEPD, HP
36iron45 2410.9EPO, THPO, HBA2, CHIT1, MPL, IFNA2
37steroid459.9IFNA2, JAK2, LIPA, HP, SLPI, GBA
38polysaccharide459.9THPO, IL2RA, GBA, CHIT1, ITGB2, HP
39cyclosporin a45 29 6011.8ABCA1, GPT, IL2RA, HP, EPO, ITGB2
40cholesterol45 29 11 2412.8LCAT, JAK2, ITGB2, HP, GBA, GPT
41thymidine45 2410.8THPO, IL2RA, GBA, HBA2, SLPI, PEPD
42cysteine459.8HP, LIPA, MPL, SLPI, THPO, IL2RA
43cisplatin45 50 60 1112.7CSF3, JAK2, TRAF2, IFNA2, IL2RA, SLPI
44vegf459.7JAK2, THPO, IL2RA, HP, IFNA2, EPO
45heparin45 29 11 2412.7SLPI, HP, THPO, IL2RA, ITGB2, LCAT
46lipid459.7ABCA1, LIPA, CHIT1, TRAF2, ITGB2, JAK2
47alanine459.6PEPD, LCAT, IFNA2, JAK2, ITGB2, MPL
48phosphatidylinositol459.6THPO, ABCA1, IL2RA, EPO, TRAF2, MPL
49tyrosine459.3JAK2, IFNA2, ITGB2, SLPI, THPO, ABCA1
50nitric oxide45 11 2411.3JAK2, ITGAX, SLPI, HP, GBA, ITGB2

GO Terms for genes affiliated with Splenomegaly

Sources:
16Gene Ontology
See all sources

Cellular components related to Splenomegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:03183810.3HP, HBA2
2extracellular spaceGO:0056159.4THPO, HP, EPO, CHIT1, CSF3, IFNA2

Biological processes related to Splenomegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:0069159.8IFNA2, JAK2, ITGB2, TRAF2, EPO, IL2RA
2blood coagulationGO:0075969.5IFNA2, JAK2, ITGB2, ITGAX, MPL, THPO

Molecular functions related to Splenomegaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I bindingGO:03418610.3ABCA1, LCAT

Products for genes affiliated with Splenomegaly

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Splenomegaly

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet