MCID: SPL039
MIFTS: 27

Split Foot malady

Bone diseases, Fetal diseases categories

Summaries for Split Foot

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32MalaCards
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MalaCards: Split Foot is related to syndactyly and split hand split foot nystagmus. An important gene associated with Split Foot is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways is Hedgehog signaling events mediated by Gli proteins. Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Aliases & Classifications for Split Foot

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Sources:
48Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Bone diseases


Aliases & Descriptions:

split foot 48


External Ids:

SNOMED-CT via Orphanet57 205358006
ICD10 via Orphanet26 Q72.7

Related Diseases for Split Foot

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Split Foot:



Diseases related to split foot

Clinical Features for Split Foot

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Drugs & Therapeutics for Split Foot

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Split Foot

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Genetic Tests for Split Foot

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Anatomical Context for Split Foot

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32MalaCards
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MalaCards organs/tissues related to Split Foot:

32
Bone

Animal Models for Split Foot or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Split Foot:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.4FGF8, DLX6, DLX5, HMX2
2MP:00053829.0TP63, SUFU, DLX5, DLX6, FGF8
3MP:00053919.0TP63, DLX5, DLX6, FGF8, RBP4
4MP:00053908.8FBXW4, DLX6, DLX5, SUFU, TP63, FGF8
5MP:00053818.8TP63, SUFU, DLX5, FGF8, DLX6
6MP:00053718.5FGF8, FBXW4, LBX1, DLX5, TP63, DLX6
7MP:00053698.4DLX5, LBX1, RBP4, FGF8, HMX2, TP63
8MP:00028738.1LBX1, RBP4, FGF8, DLX5, TP63, SUFU
9MP:00053807.5DLX5, SUFU, TLX1, LBX1, FBXW4, FGF8
10MP:00107687.4LBX1, FBXW4, BTRC, FGF8, TP63, SUFU
11MP:00036317.3TLX1, LBX1, FGF8, DLX6, SUFU, DLX5

Publications for Split Foot

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Genetic Variations for Split Foot

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Expression for genes affiliated with Split Foot

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Split Foot

Search GEO for disease gene expression data for Split Foot.

Pathways for genes affiliated with Split Foot

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Sources:
37NCBI BioSystems Database
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Pathways related to Split Foot according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SUFU, BTRC

Compounds for genes affiliated with Split Foot

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GO Terms for genes affiliated with Split Foot

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Sources:
16Gene Ontology
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Biological processes related to Split Foot according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1female genitalia morphogenesisGO:04880710.0TP63, RBP4
2anatomical structure formation involved in morphogenesisGO:04864610.0DLX5, DLX6
3epithelial cell differentiationGO:03085510.0DLX5, DLX6
4urinary bladder developmentGO:0601579.9RBP4, TP63
5inner ear morphogenesisGO:0424729.7HMX2, DLX5, DLX6
6negative regulation of smoothened signaling pathwayGO:0458799.6BTRC, SUFU
7positive regulation of mesenchymal cell proliferationGO:0020539.6TP63, FBXW4
8embryonic limb morphogenesisGO:0303269.6TP63, DLX5, DLX6, FBXW4
9skeletal system developmentGO:0015019.4DLX6, DLX5, SUFU, TP63
10heart loopingGO:0019479.1SUFU, FGF8, LBX1

Molecular functions related to Split Foot according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037008.1TP63, HMX2, DLX6, LBX1, TLX1

Products for genes affiliated with Split Foot

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Split Foot

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet