Aliases & Classifications for Spondylarthropathy

MalaCards integrated aliases for Spondylarthropathy:

Name: Spondylarthropathy 50
Spondylarthropathies 52 69

Classifications:



Summaries for Spondylarthropathy

MalaCards based summary : Spondylarthropathy, also known as spondylarthropathies, is related to spondyloarthropathy and enthesitis-related juvenile idiopathic arthritis, and has symptoms including sciatica An important gene associated with Spondylarthropathy is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drugs Adalimumab and Pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Spondyloarthropathy or spondyloarthrosis refers to any joint disease of the vertebral column. As such,... more...

Related Diseases for Spondylarthropathy

Diseases related to Spondylarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 10.8
2 enthesitis-related juvenile idiopathic arthritis 10.8
3 akaba hayasaka syndrome 10.4 B2M TNF
4 macular dystrophy, atypical vitelliform 10.4 CD163 TNF
5 hepadnavirus infection 10.4 B2M TNF
6 steatorrhea 10.3 B2M TNF
7 acquired thrombocytopenia 10.3 CD163 TNF
8 mixed lacrimal gland cancer 10.3 B2M TNF
9 heart sarcoma 10.3 B2M TNF
10 rickettsialpox 10.3 TLR4 TNF
11 low compliance bladder 10.3 TLR4 TNF
12 antigen-peptide-transporter 2 deficiency 10.3 TLR4 TNF
13 trichosporonosis 10.3 TLR4 TNF
14 aseptic meningitis 10.3 TLR4 TNF
15 alkhurma hemorrhagic fever 10.3 TLR4 TNF
16 megaloblastic anemia 10.2 TLR4 TNF
17 pericholangitis 10.2 TLR4 TNF
18 testicular infarct 10.2 TLR4 TNF
19 gastroduodenal crohn's disease 10.2 TLR4 TNF
20 bartonellosis 10.2 TLR4 TNF
21 myeloid sarcoma 10.2 TLR4 TNF
22 nasopharyngitis 10.2 TLR4 TNF
23 scabies 10.2 B2M TNF
24 mikulicz disease 10.2 TLR4 TNF
25 palmoplantar keratosis 10.2 TLR4 TNF
26 abnormal retinal correspondence 10.2 TLR4 TNF
27 iida kannari syndrome 10.2 TLR4 TNF
28 melioidosis 10.2 TLR4 TNF
29 esophagus melanoma 10.2 TLR4 TNF
30 choroiditis 10.2 TLR4 TNF
31 thrombotic thrombocytopenic purpura 10.2 B2M TLR4
32 arthritis 10.2
33 autosomal recessive type iv ehlers-danlos syndrome 10.2 TLR4 TNF
34 neonatal period electroclinical syndrome 10.2 TLR4 TNF
35 gastric ulcer 10.2 TLR4 TNF
36 glycogen storage disease viii 10.2 B2M TLR4
37 respiratory system disease 10.2 CD163 TNF
38 spindle cell variant squamous cell breast carcinoma 10.2 CD163 TLR4
39 sheehan syndrome 10.2 TLR4 TNF
40 benign eccrine breast spiradenoma 10.2 TLR4 TNF
41 calcinosis 10.2 B2M TNF
42 opportunistic bacterial infectious disease 10.2 TLR4 TNF
43 dengue disease 10.2 TLR4 TNF
44 mucocutaneous leishmaniasis 10.2 TLR4 TNF
45 synovium cancer 10.2 CD163 TNF
46 ragweed sensitivity 10.2 TLR4 TNF
47 neovascular glaucoma 10.2 TLR4 TNF
48 keratomalacia 10.1 TLR4 TNF
49 endometrial clear cell adenocarcinoma 10.1 TLR4 TNF
50 acral lentiginous melanoma 10.1 B2M TNF

Graphical network of the top 20 diseases related to Spondylarthropathy:



Diseases related to Spondylarthropathy

Symptoms & Phenotypes for Spondylarthropathy

UMLS symptoms related to Spondylarthropathy:


sciatica

MGI Mouse Phenotypes related to Spondylarthropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 TNF B2M CD163 LTA TLR4
2 hematopoietic system MP:0005397 9.72 TNF B2M CD163 LTA TLR4
3 immune system MP:0005387 9.65 TLR4 TNF B2M CD163 LTA
4 liver/biliary system MP:0005370 9.46 TNF B2M LTA TLR4
5 respiratory system MP:0005388 9.13 TLR4 TNF LTA
6 vision/eye MP:0005391 8.92 TLR4 TNF CD163 LTA

Drugs & Therapeutics for Spondylarthropathy

Drugs for Spondylarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 223)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
2
Pamidronate Approved Phase 4 40391-99-9 4674
3
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
4
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
5
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
7
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
8
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
9
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
10
Aceclofenac Approved Phase 4 89796-99-6
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
14
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
15
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
18 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
19 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Adrenocorticotropic Hormone Phase 4
21 beta-endorphin Phase 4
22 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
23 Hormones Phase 4,Phase 2,Phase 3,Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
25 Melanocyte-Stimulating Hormones Phase 4
26 Analgesics Phase 4,Phase 2,Phase 3
27 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
29 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
31 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
33 Natriuretic Agents Phase 4
34 Natriuretic Peptide, Brain Phase 4
35 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
36 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
37 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
38 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
39 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
40 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
42 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
43 Vaccines Phase 4,Phase 2
44 Anti-Infective Agents Phase 4,Phase 2,Phase 3
45 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
46 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
47 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
48 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
49 Endothelial Growth Factors Phase 4
50 Mitogens Phase 4

Interventional clinical trials:

(show top 50) (show all 467)

id Name Status NCT ID Phase Drugs
1 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
2 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
3 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
4 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
5 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
6 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
7 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
8 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
9 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
10 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
11 Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 4
12 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4 etanercept
13 A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics Completed NCT02470481 Phase 4
14 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4 Adalimumab
15 National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study Completed NCT01123265 Phase 4 Methotrexate;Anti-TNF
16 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4 Infliximab;Etanercept
17 REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®) Completed NCT00127842 Phase 4 Etanercept
18 Prevalence of Psoriatic Arthritis in Adults With Psoriasis: An Estimate From Dermatology Practice Completed NCT01147874 Phase 4
19 Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis Completed NCT00161655 Phase 4 Etanercept;Methotrexate
20 Enbrel® in Psoriatic Arthritis Completed NCT00111124 Phase 4 Enbrel®
21 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
22 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
23 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
24 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
25 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4 Enbrel
26 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
27 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
28 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
29 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
30 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
31 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
32 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
33 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
34 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
35 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4 Etanercept
36 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
37 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
38 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
39 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
40 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
41 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
42 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
43 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4 Etanercept
44 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
45 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
46 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
47 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4 alendronate
48 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4 Infliximab; observational study;Methotrexate; observational study
49 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
50 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4 Infliximab

Search NIH Clinical Center for Spondylarthropathy

Genetic Tests for Spondylarthropathy

Anatomical Context for Spondylarthropathy

MalaCards organs/tissues related to Spondylarthropathy:

39
Bone, Testes, Endothelial, T Cells, Skin, Liver, Colon

Publications for Spondylarthropathy

Articles related to Spondylarthropathy:

(show top 50) (show all 172)
id Title Authors Year
1
Immune cell transcript modules reveal leukocyte heterogeneity in synovial biopsies of seronegative spondylarthropathy patients. ( 25526985 )
2014
2
Severe deafness associated with Crohn's disease and spondylarthropathy: successful treatment with anti-TNF. ( 23221328 )
2013
3
Collagenous colitis and spondylarthropathy. ( 22701491 )
2012
4
Performance of the assessment in Spondyloarthritis International Society classification for axial and peripheral spondyloarthritis in an established clinical cohort: comparison with criteria sets of Amor and the European Spondylarthropathy Study Group. ( 22337240 )
2012
5
Late-onset spondylarthropathy mimicking multiple osteoblastic metastases. ( 22771134 )
2012
6
Novel development in extraintestinal manifestations and spondylarthropathy. ( 21640926 )
2011
7
"Spinal degeneration: beyond degenerative disc disease": how to discriminate degeneration from spondylarthropathies? ( 21863426 )
2011
8
HLA-b27 subtypes in patients with spondylarthropathies, IgE levels against some allergens and their relationship to the disease parameters. ( 19750986 )
2009
9
Recurrence of spondylarthropathy among first-degree relatives of patients: a systematic cross-sectional study. ( 18413442 )
2009
10
Immunologic and genetic links between spondylarthropathies and inflammatory bowel diseases. ( 19530505 )
2009
11
Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy. ( 19464220 )
2009
12
Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity. ( 19570209 )
2009
13
The Bath metrology index as assessed by a trained and an untrained rater in patients with spondylarthropathy: a study of intra- and inter-rater agreements. ( 18726550 )
2009
14
Infliximab for treating axial spondylarthropathy in everyday practice. ( 19064331 )
2009
15
Association of hereditary angioneurotic edema with spondylarthropathy: report of a case. ( 17980638 )
2008
16
Impact of three anti-TNFalpha biologics on existing and emergent autoimmunity in rheumatoid arthritis and spondylarthropathy patients. ( 18587633 )
2008
17
Association of angiotensin-converting enzyme (ACE) gene insertion-deletion polymorphism with spondylarthropathies. ( 17713861 )
2008
18
An exceptional manifestation of spondylarthropathy: Destructive proximal tibio-fibular arthritis. ( 18406190 )
2008
19
Ankylosing spondylitis and spondylarthropathy presenting with a clinical picture of adult onset Still's disease: case series. ( 18658204 )
2008
20
Six-month response to anti-TNF drugs in axial spondylarthropathy according to the fulfillment or not of New-York criteria for ankylosing spondylitis or French recommendations for anti-TNF use. A "real life" retrospective study on 175 patients. ( 18848489 )
2008
21
Disappearing condyles in a patient with seronegative spondylarthropathy. ( 16368170 )
2007
22
25 mg etanercept once weekly in rheumatoid arthritis and spondylarthropathy. ( 17337351 )
2007
23
First appearance of Crohn's disease following infliximab treatment for spondylarthropathy. ( 17506005 )
2007
24
A hidradenitis suppurativa related SAPHO case associated with features resembling spondylarthropathy and proteinuria. ( 16680392 )
2007
25
Reiter syndrome triggered by adalimumab (Humira) and leflunomide (Arava) in a patient with ankylosing spondylarthropathy and Crohn disease. ( 17199598 )
2007
26
Safety of anti-TNF-alpha therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis. ( 16603583 )
2006
27
Magnetic resonance imaging guided corticosteroid injection of sacroiliac joints in patients with spondylarthropathy. Are multiple injections more beneficial? ( 16010559 )
2006
28
Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study. ( 16901960 )
2006
29
Collagenous colitis and spondylarthropathy. ( 16739191 )
2006
30
Intravenous application of omega-3 fatty acids in a patient with active spondylarthropathy--a case report. ( 16220223 )
2006
31
Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms with spondylarthropathies in a Hungarian population. ( 16567359 )
2006
32
Spondylarthropathy striking prevalence in a 19th-20th century Portuguese collection. ( 16564195 )
2006
33
Genetic control of experimental spondylarthropathy. ( 16059927 )
2005
34
A study of ten Japanese patients with seronegative spondylarthropathy: a tentative proposal. ( 17029088 )
2005
35
Distribution of HLA-B27 subtypes in Sardinia and continental Italy and their association with spondylarthropathies. ( 16200572 )
2005
36
Two major spondylarthropathy phenotypes are distinguished by pattern analysis in multiplex families. ( 15818650 )
2005
37
Deltoideal acromial enthesopathy in ankylosing spondylitis and in spondylarthropathies: comment on the article by Lambert et al. ( 16208667 )
2005
38
[Spondylarthropathies and anti-TNFalpha drugs]. ( 16154026 )
2005
39
Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy. ( 15986373 )
2005
40
Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy: a role for scintigraphy with 99mTc-infliximab. ( 15818709 )
2005
41
Late-onset ankylosing spondylitis and related spondylarthropathies: clinical and radiological characteristics and pharmacological treatment options. ( 15974637 )
2005
42
Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathies. ( 16329106 )
2005
43
The HLA-B*5703 allele confers susceptibility to the development of spondylarthropathies in Zambian human immunodeficiency virus-infected patients with slow progression to acquired immunodeficiency syndrome. ( 15641063 )
2005
44
Mesalazine-associated acute tubulointerstitial nephritis in a patient with spondylarthropathy. ( 16222356 )
2005
45
Anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondylarthropathy. ( 15986366 )
2005
46
Magnetic resonance imaging of sacroiliitis in early seronegative spondylarthropathy. Abnormalities correlated to clinical and laboratory findings. ( 13130148 )
2004
47
Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. ( 15146432 )
2004
48
Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: a prospective study in 154 consecutive patients. ( 15457462 )
2004
49
Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondylarthropathy. ( 15146433 )
2004
50
MRI abnormalities of sacroiliac joints in early spondylarthropathy: a 1-year follow-up study. ( 15513683 )
2004

Variations for Spondylarthropathy

Expression for Spondylarthropathy

Search GEO for disease gene expression data for Spondylarthropathy.

Pathways for Spondylarthropathy

Pathways related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 B2M LTA TNF
2
Show member pathways
12.4 LTA TLR4 TNF
3
Show member pathways
12.25 LTA TLR4 TNF
4
Show member pathways
12.22 LTA TLR4 TNF
5 11.64 LTA TNF
6 11.58 TLR4 TNF
7 11.55 TLR4 TNF
8
Show member pathways
11.51 LTA TNF
9 11.48 LTA TNF
10
Show member pathways
11.46 LTA TLR4 TNF
11 11.45 TLR4 TNF
12 11.43 CD163 TNF
13 11.38 TLR4 TNF
14 11.31 LTA TLR4 TNF
15
Show member pathways
11.28 B2M TNF
16 11.22 TLR4 TNF
17
Show member pathways
11.13 LTA TNF
18 11.09 TLR4 TNF
19 11.05 TLR4 TNF
20 10.98 LTA TLR4 TNF
21 10.87 TLR4 TNF
22 10.53 LTA TLR4 TNF

GO Terms for Spondylarthropathy

Cellular components related to Spondylarthropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 B2M TLR4 TNF
2 external side of plasma membrane GO:0009897 8.92 B2M CD163 TLR4 TNF

Biological processes related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.71 CD163 TLR4 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.58 LTA TNF
3 apoptotic signaling pathway GO:0097190 9.58 TLR4 TNF
4 positive regulation of JNK cascade GO:0046330 9.57 TLR4 TNF
5 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.56 TLR4 TNF
6 immune response GO:0006955 9.56 B2M LTA TLR4 TNF
7 humoral immune response GO:0006959 9.55 LTA TNF
8 positive regulation of interleukin-6 production GO:0032755 9.52 TLR4 TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.51 TLR4 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.49 TLR4 TNF
11 positive regulation of interleukin-8 production GO:0032757 9.48 TLR4 TNF
12 negative regulation of interleukin-6 production GO:0032715 9.46 TLR4 TNF
13 positive regulation of NF-kappaB import into nucleus GO:0042346 9.43 TLR4 TNF
14 positive regulation of chemokine production GO:0032722 9.4 TLR4 TNF
15 negative regulation of growth of symbiont in host GO:0044130 9.37 LTA TNF
16 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.32 TLR4 TNF
17 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.16 LTA TNF
18 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF
19 positive regulation of interferon-gamma production GO:0032729 8.8 LTA TLR4 TNF

Molecular functions related to Spondylarthropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 LTA TNF

Sources for Spondylarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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