Aliases & Classifications for Spondylarthropathy

Aliases & Descriptions for Spondylarthropathy:

Name: Spondylarthropathy 50
Spondylarthropathies 52 69

Classifications:



Summaries for Spondylarthropathy

MalaCards based summary : Spondylarthropathy, also known as spondylarthropathies, is related to rheumatoid arthritis and spondyloarthropathy, and has symptoms including sciatica An important gene associated with Spondylarthropathy is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drugs Methotrexate and Sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and bone, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Spondyloarthropathy or spondyloarthrosis refers to any joint disease of the vertebral column. As such,... more...

Related Diseases for Spondylarthropathy

Diseases related to Spondylarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.8 LTA TLR4 TNF
2 spondyloarthropathy 10.9
3 spondyloarthropathy 1 10.8
4 enthesitis-related juvenile idiopathic arthritis 10.8
5 arthritis 10.2
6 al gazali sabrinathan nair syndrome 10.2 B2M TNF
7 madras motor neuron disease 10.2 CD163 TNF
8 glucose intolerance 10.2 B2M TNF
9 hereditary alpha tryptasemia syndrome 10.2 B2M TNF
10 low compliance bladder 10.1 TLR4 TNF
11 spotted fever 10.1 TLR4 TNF
12 aortic coarctation 10.1 TLR4 TNF
13 parkinson disease 11 10.1 TLR4 TNF
14 cockayne syndrome 10.1 B2M TNF
15 aseptic meningitis 10.1 TLR4 TNF
16 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 TLR4 TNF
17 parasitic ichthyosporea infectious disease 10.1 TLR4 TNF
18 mikulicz disease 10.1 TLR4 TNF
19 anterior foramen magnum meningioma 10.1 B2M TNF
20 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 TLR4 TNF
21 rickettsialpox 10.1 TLR4 TNF
22 autosomal recessive type iv ehlers-danlos syndrome 10.1 TLR4 TNF
23 neuropathy 10.1 TLR4 TNF
24 crohn's colitis 10.1 TLR4 TNF
25 abnormal retinal correspondence 10.1 TLR4 TNF
26 inappropriate adh syndrome 10.1 TLR4 TNF
27 ovarian cystic teratoma 10.1 TLR4 TNF
28 dentin caries 10.1 TLR4 TNF
29 pericholangitis 10.1 TLR4 TNF
30 immunoglobulin g deficiency 10.1 TLR4 TNF
31 myiasis 10.1 TLR4 TNF
32 blepharochalasis 10.1 TLR4 TNF
33 choroiditis 10.1 TLR4 TNF
34 mansonelliasis 10.1 TLR4 TNF
35 glycogen storage disease viii 10.1 B2M TLR4
36 infancy electroclinical syndrome 10.1 TLR4 TNF
37 duodenal somatostatinoma 10.1 CD163 TLR4
38 unilateral hypoactive labyrinth 10.1 TLR4 TNF
39 dengue hemorrhagic fever 10.1 TLR4 TNF
40 benign eccrine breast spiradenoma 10.1 TLR4 TNF
41 liver inflammatory pseudotumor 10.1 TLR4 TNF
42 sclerosing adenosis of breast 10.1 B2M TNF
43 hallucinogen dependence 10.1 TLR4 TNF
44 respiratory system disease 10.1 CD163 TNF
45 keratomalacia 10.1 TLR4 TNF
46 neovascular glaucoma 10.1 TLR4 TNF
47 synovium cancer 10.1 CD163 TNF
48 optic nerve hypoplasia 10.1 TLR4 TNF
49 thymic neuroendocrine carcinoma 10.1 LTA TNF
50 drug dependence 10.1 LTA TNF

Graphical network of the top 20 diseases related to Spondylarthropathy:



Diseases related to Spondylarthropathy

Symptoms & Phenotypes for Spondylarthropathy

UMLS symptoms related to Spondylarthropathy:


sciatica

MGI Mouse Phenotypes related to Spondylarthropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.72 LTA TLR4 TNF B2M CD163
2 hematopoietic system MP:0005397 9.65 CD163 LTA TLR4 TNF B2M
3 immune system MP:0005387 9.55 CD163 LTA TLR4 TNF B2M
4 liver/biliary system MP:0005370 9.26 LTA TLR4 TNF B2M
5 vision/eye MP:0005391 8.92 CD163 LTA TLR4 TNF

Drugs & Therapeutics for Spondylarthropathy

Drugs for Spondylarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 208)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
2
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
3
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
4
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
5
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
6
Certolizumab pegol Approved Phase 4,Phase 3,Phase 1 428863-50-7
7
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
8
Acetaminophen Approved Phase 4 103-90-2 1983
9
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
10
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
11
Pamidronate Approved Phase 4 40391-99-9 4674
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
14
Aceclofenac Approved Phase 4 89796-99-6
15
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
16
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
18 beta-endorphin Phase 4
19 Analgesics Phase 4,Phase 2,Phase 3
20 Chelating Agents Phase 4,Phase 3
21 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
22 Natriuretic Agents Phase 4
23 Natriuretic Peptide, Brain Phase 4
24 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
25 Adrenocorticotropic Hormone Phase 4
26 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
27 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
28 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
29 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Hormone Antagonists Phase 4,Phase 2,Phase 3
31 Hormones Phase 4,Phase 2,Phase 3
32 Vaccines Phase 4,Phase 2
33 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
35 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
36 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
37 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
38 Anti-Infective Agents Phase 4,Phase 2,Phase 3
39 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
43 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
44 Melanocyte-Stimulating Hormones Phase 4
45 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
46 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
47 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
48 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Mitogens Phase 4
50 Cholestyramine Resin Phase 4

Interventional clinical trials:

(show top 50) (show all 453)
id Name Status NCT ID Phase
1 Effects of Different Anti-rheumatic Treatments of Arthritis on Antibody Response Following Pneumococcal Vaccination Using Prevenar® Unknown status NCT00828997 Phase 4
2 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4
3 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4
4 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4
5 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4
6 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4
7 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4
8 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4
9 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4
10 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4
11 Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 4
12 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4
13 A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics Completed NCT02470481 Phase 4
14 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4
15 National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study Completed NCT01123265 Phase 4
16 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4
17 REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®) Completed NCT00127842 Phase 4
18 Prevalence of Psoriatic Arthritis in Adults With Psoriasis: An Estimate From Dermatology Practice Completed NCT01147874 Phase 4
19 Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis Completed NCT00161655 Phase 4
20 Enbrel® in Psoriatic Arthritis Completed NCT00111124 Phase 4
21 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4
22 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4
23 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
24 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4
25 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4
26 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4
27 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4
28 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4
29 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4
30 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
31 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
32 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
33 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4
34 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4
35 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4
36 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4
37 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4
38 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4
39 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4
40 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4
41 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4
42 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4
43 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4
44 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4
45 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4
46 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4
47 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4
48 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
49 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4
50 Study Evaluating Etanercept in Patients With Rheumatoid Arthritis(RA), Juvenile Idiopathic Arthritis (JIA), or Psoriatic Arthritis (PsA) in Spain Completed NCT00195377 Phase 4

Search NIH Clinical Center for Spondylarthropathy

Genetic Tests for Spondylarthropathy

Anatomical Context for Spondylarthropathy

MalaCards organs/tissues related to Spondylarthropathy:

39
T Cells, Spinal Cord, Bone, Neutrophil, Endothelial

Publications for Spondylarthropathy

Articles related to Spondylarthropathy:

(show top 50) (show all 172)
id Title Authors Year
1
Immune cell transcript modules reveal leukocyte heterogeneity in synovial biopsies of seronegative spondylarthropathy patients. ( 25526985 )
2014
2
Severe deafness associated with Crohn's disease and spondylarthropathy: successful treatment with anti-TNF. ( 23221328 )
2013
3
Performance of the assessment in Spondyloarthritis International Society classification for axial and peripheral spondyloarthritis in an established clinical cohort: comparison with criteria sets of Amor and the European Spondylarthropathy Study Group. ( 22337240 )
2012
4
Collagenous colitis and spondylarthropathy. ( 22701491 )
2012
5
Late-onset spondylarthropathy mimicking multiple osteoblastic metastases. ( 22771134 )
2012
6
Novel development in extraintestinal manifestations and spondylarthropathy. ( 21640926 )
2011
7
"Spinal degeneration: beyond degenerative disc disease": how to discriminate degeneration from spondylarthropathies? ( 21863426 )
2011
8
HLA-b27 subtypes in patients with spondylarthropathies, IgE levels against some allergens and their relationship to the disease parameters. ( 19750986 )
2009
9
The Bath metrology index as assessed by a trained and an untrained rater in patients with spondylarthropathy: a study of intra- and inter-rater agreements. ( 18726550 )
2009
10
Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity. ( 19570209 )
2009
11
Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy. ( 19464220 )
2009
12
Infliximab for treating axial spondylarthropathy in everyday practice. ( 19064331 )
2009
13
Immunologic and genetic links between spondylarthropathies and inflammatory bowel diseases. ( 19530505 )
2009
14
Recurrence of spondylarthropathy among first-degree relatives of patients: a systematic cross-sectional study. ( 18413442 )
2009
15
Association of angiotensin-converting enzyme (ACE) gene insertion-deletion polymorphism with spondylarthropathies. ( 17713861 )
2008
16
Ankylosing spondylitis and spondylarthropathy presenting with a clinical picture of adult onset Still's disease: case series. ( 18658204 )
2008
17
Association of hereditary angioneurotic edema with spondylarthropathy: report of a case. ( 17980638 )
2008
18
An exceptional manifestation of spondylarthropathy: Destructive proximal tibio-fibular arthritis. ( 18406190 )
2008
19
Six-month response to anti-TNF drugs in axial spondylarthropathy according to the fulfillment or not of New-York criteria for ankylosing spondylitis or French recommendations for anti-TNF use. A "real life" retrospective study on 175 patients. ( 18848489 )
2008
20
Impact of three anti-TNFalpha biologics on existing and emergent autoimmunity in rheumatoid arthritis and spondylarthropathy patients. ( 18587633 )
2008
21
Disappearing condyles in a patient with seronegative spondylarthropathy. ( 16368170 )
2007
22
First appearance of Crohn's disease following infliximab treatment for spondylarthropathy. ( 17506005 )
2007
23
25 mg etanercept once weekly in rheumatoid arthritis and spondylarthropathy. ( 17337351 )
2007
24
Reiter syndrome triggered by adalimumab (Humira) and leflunomide (Arava) in a patient with ankylosing spondylarthropathy and Crohn disease. ( 17199598 )
2007
25
A hidradenitis suppurativa related SAPHO case associated with features resembling spondylarthropathy and proteinuria. ( 16680392 )
2007
26
Spondylarthropathy striking prevalence in a 19th-20th century Portuguese collection. ( 16564195 )
2006
27
Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms with spondylarthropathies in a Hungarian population. ( 16567359 )
2006
28
Collagenous colitis and spondylarthropathy. ( 16739191 )
2006
29
Magnetic resonance imaging guided corticosteroid injection of sacroiliac joints in patients with spondylarthropathy. Are multiple injections more beneficial? ( 16010559 )
2006
30
Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study. ( 16901960 )
2006
31
Safety of anti-TNF-alpha therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis. ( 16603583 )
2006
32
Intravenous application of omega-3 fatty acids in a patient with active spondylarthropathy--a case report. ( 16220223 )
2006
33
Deltoideal acromial enthesopathy in ankylosing spondylitis and in spondylarthropathies: comment on the article by Lambert et al. ( 16208667 )
2005
34
Distribution of HLA-B27 subtypes in Sardinia and continental Italy and their association with spondylarthropathies. ( 16200572 )
2005
35
Two major spondylarthropathy phenotypes are distinguished by pattern analysis in multiplex families. ( 15818650 )
2005
36
Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy: a role for scintigraphy with 99mTc-infliximab. ( 15818709 )
2005
37
Genetic control of experimental spondylarthropathy. ( 16059927 )
2005
38
Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathies. ( 16329106 )
2005
39
[Spondylarthropathies and anti-TNFalpha drugs]. ( 16154026 )
2005
40
Late-onset ankylosing spondylitis and related spondylarthropathies: clinical and radiological characteristics and pharmacological treatment options. ( 15974637 )
2005
41
Mesalazine-associated acute tubulointerstitial nephritis in a patient with spondylarthropathy. ( 16222356 )
2005
42
The HLA-B*5703 allele confers susceptibility to the development of spondylarthropathies in Zambian human immunodeficiency virus-infected patients with slow progression to acquired immunodeficiency syndrome. ( 15641063 )
2005
43
Anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondylarthropathy. ( 15986366 )
2005
44
Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy. ( 15986373 )
2005
45
A study of ten Japanese patients with seronegative spondylarthropathy: a tentative proposal. ( 17029088 )
2005
46
Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: a prospective study in 154 consecutive patients. ( 15457462 )
2004
47
MRI abnormalities of sacroiliac joints in early spondylarthropathy: a 1-year follow-up study. ( 15513683 )
2004
48
Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. ( 15146432 )
2004
49
Mental health status and leisure-time physical activity contribute to fatigue intensity in patients with spondylarthropathy. ( 15593104 )
2004
50
Update in spondylarthropathy. ( 14872468 )
2004

Variations for Spondylarthropathy

Expression for Spondylarthropathy

Search GEO for disease gene expression data for Spondylarthropathy.

Pathways for Spondylarthropathy

Pathways related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 B2M LTA TNF
2
Show member pathways
12.39 LTA TLR4 TNF
3
Show member pathways
12.25 LTA TLR4 TNF
4
Show member pathways
12.22 LTA TLR4 TNF
5 11.64 LTA TNF
6 11.58 TLR4 TNF
7 11.55 TLR4 TNF
8
Show member pathways
11.51 LTA TNF
9 11.48 LTA TNF
10
Show member pathways
11.46 LTA TLR4 TNF
11 11.45 CD163 TNF
12 11.44 TLR4 TNF
13 11.39 TLR4 TNF
14 11.31 LTA TLR4 TNF
15
Show member pathways
11.28 B2M TNF
16 11.22 TLR4 TNF
17
Show member pathways
11.13 LTA TNF
18 11.09 TLR4 TNF
19 11.05 TLR4 TNF
20 10.98 LTA TLR4 TNF
21 10.87 TLR4 TNF
22 10.53 LTA TLR4 TNF

GO Terms for Spondylarthropathy

Cellular components related to Spondylarthropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 B2M TLR4 TNF
2 external side of plasma membrane GO:0009897 8.92 B2M CD163 TLR4 TNF

Biological processes related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 CD163 TLR4 TNF
2 immune response GO:0006955 9.62 B2M LTA TLR4 TNF
3 apoptotic signaling pathway GO:0097190 9.6 TLR4 TNF
4 positive regulation of JNK cascade GO:0046330 9.59 TLR4 TNF
5 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.58 TLR4 TNF
6 humoral immune response GO:0006959 9.58 LTA TNF
7 cellular response to lipopolysaccharide GO:0071222 9.58 B2M TLR4 TNF
8 defense response to Gram-negative bacterium GO:0050829 9.57 B2M TLR4
9 positive regulation of interleukin-6 production GO:0032755 9.55 TLR4 TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 TLR4 TNF
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 TLR4 TNF
12 positive regulation of interleukin-8 production GO:0032757 9.51 TLR4 TNF
13 negative regulation of interleukin-6 production GO:0032715 9.49 TLR4 TNF
14 positive regulation of NF-kappaB import into nucleus GO:0042346 9.48 TLR4 TNF
15 positive regulation of chemokine production GO:0032722 9.46 TLR4 TNF
16 negative regulation of growth of symbiont in host GO:0044130 9.43 LTA TNF
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.37 TLR4 TNF
18 defense response to Gram-positive bacterium GO:0050830 9.33 B2M LTA TNF
19 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 LTA TNF
20 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF
21 positive regulation of interferon-gamma production GO:0032729 8.8 LTA TLR4 TNF

Molecular functions related to Spondylarthropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 LTA TNF

Sources for Spondylarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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