Aliases & Classifications for Spondylarthropathy

MalaCards integrated aliases for Spondylarthropathy:

Name: Spondylarthropathy 49
Spondylarthropathies 51 69

Classifications:



Summaries for Spondylarthropathy

MalaCards based summary : Spondylarthropathy, also known as spondylarthropathies, is related to synovitis and spondylitis, and has symptoms including sciatica An important gene associated with Spondylarthropathy is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drugs Methotrexate and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and t cells, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Spondyloarthropathy or spondyloarthrosis refers to any joint disease of the vertebral column. As such,... more...

Related Diseases for Spondylarthropathy

Diseases related to Spondylarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 synovitis 30.1 CD163 TNF
2 spondylitis 29.9 LTA TNF
3 acquired immunodeficiency syndrome 29.6 B2M TNF
4 juvenile rheumatoid arthritis 29.6 LTA TNF
5 arthropathy 29.6 B2M TNF
6 psoriatic arthritis 28.9 LTA TNF
7 inflammatory bowel disease 28.9 LTA TLR4 TNF
8 spondyloarthropathy 1 11.3
9 spondyloarthropathy 11.1
10 enthesitis-related juvenile idiopathic arthritis 10.9
11 arthritis 10.3
12 aids dementia complex 10.2 B2M TNF
13 macrophage activation syndrome 10.2 CD163 TNF
14 pleural tuberculosis 10.2 B2M TNF
15 rheumatoid arthritis 10.2
16 inner ear disease 10.2 B2M TNF
17 human immunodeficiency virus infectious disease 10.2 B2M TNF
18 trench fever 10.2 TLR4 TNF
19 tympanosclerosis 10.2 TLR4 TNF
20 anterior uveitis 10.1 TLR4 TNF
21 penicilliosis 10.1 TLR4 TNF
22 alveolar echinococcosis 10.1 TLR4 TNF
23 scrub typhus 10.1 TLR4 TNF
24 middle ear disease 10.1 TLR4 TNF
25 q fever 10.1 TLR4 TNF
26 perinatal necrotizing enterocolitis 10.1 TLR4 TNF
27 peritonitis 10.1 B2M TNF
28 ileitis 10.1 TLR4 TNF
29 uterine anomalies 10.1 TLR4 TNF
30 legionellosis 10.1 TLR4 TNF
31 keratoconjunctivitis sicca 10.1 TLR4 TNF
32 bacterial vaginosis 10.1 TLR4 TNF
33 idiopathic neutropenia 10.1 TLR4 TNF
34 paracoccidioidomycosis 10.1 TLR4 TNF
35 melioidosis 10.1 TLR4 TNF
36 brucellosis 10.1 TLR4 TNF
37 rheumatic disease 10.1 CD163 TNF
38 pyelonephritis 10.1 TLR4 TNF
39 urinary system disease 10.1 B2M TNF
40 aggressive periodontitis 10.1 TLR4 TNF
41 chorioamnionitis 10.1 TLR4 TNF
42 filariasis 10.1 TLR4 TNF
43 chronic pyelonephritis 10.1 B2M TLR4
44 lymphadenitis 10.1 TLR4 TNF
45 pyelitis 10.1 B2M TLR4
46 cutaneous leishmaniasis 10.1 TLR4 TNF
47 enterobiasis 10.1 CD163 TLR4
48 primary bacterial infectious disease 10.1 TLR4 TNF
49 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 TLR4 TNF
50 cystitis 10.1 TLR4 TNF

Graphical network of the top 20 diseases related to Spondylarthropathy:



Diseases related to Spondylarthropathy

Symptoms & Phenotypes for Spondylarthropathy

UMLS symptoms related to Spondylarthropathy:


sciatica

MGI Mouse Phenotypes related to Spondylarthropathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 LTA TLR4 TNF B2M CD163
2 hematopoietic system MP:0005397 9.72 LTA TLR4 TNF B2M CD163
3 immune system MP:0005387 9.65 LTA TLR4 TNF B2M CD163
4 liver/biliary system MP:0005370 9.46 LTA TLR4 TNF B2M
5 respiratory system MP:0005388 9.26 LTA TLR4 TNF CD163
6 vision/eye MP:0005391 8.92 CD163 LTA TLR4 TNF

Drugs & Therapeutics for Spondylarthropathy

Drugs for Spondylarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
2
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
3
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5359476 5353980
4
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
5
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
6
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
7
Pamidronate Approved Phase 4 40391-99-9 4674
8
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
9
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
12
Hydroxychloroquine Approved Phase 4,Phase 3 118-42-3 3652
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
15
Aceclofenac Approved, Investigational Phase 4 89796-99-6
16
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
19 beta-endorphin Phase 4
20 Analgesics Phase 4,Phase 2,Phase 3
21 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
22 Adrenocorticotropic Hormone Phase 4
23 Natriuretic Agents Phase 4
24 Natriuretic Peptide, Brain Phase 4
25 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
26 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
27 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
28 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
29 Vaccines Phase 4,Phase 2
30 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
31 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
32 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
34 Hormones Phase 4,Phase 2,Phase 3,Phase 1
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
38 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
39 Anti-Infective Agents Phase 4,Phase 2,Phase 3
40 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
41 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
43 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
44 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
46 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
47 Melanocyte-Stimulating Hormones Phase 4
48 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
49 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 491)

# Name Status NCT ID Phase Drugs
1 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
2 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
3 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
4 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
5 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
6 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
7 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
8 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
9 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
10 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
11 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
12 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
13 Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 4
14 A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics Completed NCT02470481 Phase 4
15 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4 Adalimumab
16 National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study Completed NCT01123265 Phase 4 Methotrexate;Anti-TNF
17 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4 etanercept
18 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
19 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
20 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4 Infliximab;Etanercept
21 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
22 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
23 REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®) Completed NCT00127842 Phase 4 Etanercept
24 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
25 Prevalence of Psoriatic Arthritis in Adults With Psoriasis: An Estimate From Dermatology Practice Completed NCT01147874 Phase 4
26 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
27 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4 Enbrel
28 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
29 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
30 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
31 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
32 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4 alendronate
33 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
34 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
35 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
36 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
37 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
38 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
39 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4 Infliximab; observational study;Methotrexate; observational study
40 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4 Etanercept
41 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
42 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
43 Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis Completed NCT00161655 Phase 4 Etanercept;Methotrexate
44 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
45 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
46 Enbrel® in Psoriatic Arthritis Completed NCT00111124 Phase 4 Enbrel®
47 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
48 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
49 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
50 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4 Infliximab

Search NIH Clinical Center for Spondylarthropathy

Genetic Tests for Spondylarthropathy

Anatomical Context for Spondylarthropathy

MalaCards organs/tissues related to Spondylarthropathy:

38
Testes, Bone, T Cells, Endothelial, Skin, Liver, Colon

Publications for Spondylarthropathy

Articles related to Spondylarthropathy:

(show top 50) (show all 172)
# Title Authors Year
1
Immune cell transcript modules reveal leukocyte heterogeneity in synovial biopsies of seronegative spondylarthropathy patients. ( 25526985 )
2014
2
Severe deafness associated with Crohn's disease and spondylarthropathy: successful treatment with anti-TNF. ( 23221328 )
2013
3
Performance of the assessment in Spondyloarthritis International Society classification for axial and peripheral spondyloarthritis in an established clinical cohort: comparison with criteria sets of Amor and the European Spondylarthropathy Study Group. ( 22337240 )
2012
4
Collagenous colitis and spondylarthropathy. ( 22701491 )
2012
5
Late-onset spondylarthropathy mimicking multiple osteoblastic metastases. ( 22771134 )
2012
6
Novel development in extraintestinal manifestations and spondylarthropathy. ( 21640926 )
2011
7
"Spinal degeneration: beyond degenerative disc disease": how to discriminate degeneration from spondylarthropathies? ( 21863426 )
2011
8
Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy. ( 19464220 )
2009
9
Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity. ( 19570209 )
2009
10
HLA-b27 subtypes in patients with spondylarthropathies, IgE levels against some allergens and their relationship to the disease parameters. ( 19750986 )
2009
11
Recurrence of spondylarthropathy among first-degree relatives of patients: a systematic cross-sectional study. ( 18413442 )
2009
12
Infliximab for treating axial spondylarthropathy in everyday practice. ( 19064331 )
2009
13
The Bath metrology index as assessed by a trained and an untrained rater in patients with spondylarthropathy: a study of intra- and inter-rater agreements. ( 18726550 )
2009
14
Immunologic and genetic links between spondylarthropathies and inflammatory bowel diseases. ( 19530505 )
2009
15
Six-month response to anti-TNF drugs in axial spondylarthropathy according to the fulfillment or not of New-York criteria for ankylosing spondylitis or French recommendations for anti-TNF use. A "real life" retrospective study on 175 patients. ( 18848489 )
2008
16
Association of hereditary angioneurotic edema with spondylarthropathy: report of a case. ( 17980638 )
2008
17
Association of angiotensin-converting enzyme (ACE) gene insertion-deletion polymorphism with spondylarthropathies. ( 17713861 )
2008
18
Ankylosing spondylitis and spondylarthropathy presenting with a clinical picture of adult onset Still's disease: case series. ( 18658204 )
2008
19
An exceptional manifestation of spondylarthropathy: Destructive proximal tibio-fibular arthritis. ( 18406190 )
2008
20
Impact of three anti-TNFalpha biologics on existing and emergent autoimmunity in rheumatoid arthritis and spondylarthropathy patients. ( 18587633 )
2008
21
First appearance of Crohn's disease following infliximab treatment for spondylarthropathy. ( 17506005 )
2007
22
25 mg etanercept once weekly in rheumatoid arthritis and spondylarthropathy. ( 17337351 )
2007
23
Reiter syndrome triggered by adalimumab (Humira) and leflunomide (Arava) in a patient with ankylosing spondylarthropathy and Crohn disease. ( 17199598 )
2007
24
A hidradenitis suppurativa related SAPHO case associated with features resembling spondylarthropathy and proteinuria. ( 16680392 )
2007
25
Disappearing condyles in a patient with seronegative spondylarthropathy. ( 16368170 )
2007
26
Spondylarthropathy striking prevalence in a 19th-20th century Portuguese collection. ( 16564195 )
2006
27
Collagenous colitis and spondylarthropathy. ( 16739191 )
2006
28
Safety of anti-TNF-alpha therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis. ( 16603583 )
2006
29
Intravenous application of omega-3 fatty acids in a patient with active spondylarthropathy--a case report. ( 16220223 )
2006
30
Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms with spondylarthropathies in a Hungarian population. ( 16567359 )
2006
31
Magnetic resonance imaging guided corticosteroid injection of sacroiliac joints in patients with spondylarthropathy. Are multiple injections more beneficial? ( 16010559 )
2006
32
Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study. ( 16901960 )
2006
33
The HLA-B*5703 allele confers susceptibility to the development of spondylarthropathies in Zambian human immunodeficiency virus-infected patients with slow progression to acquired immunodeficiency syndrome. ( 15641063 )
2005
34
A study of ten Japanese patients with seronegative spondylarthropathy: a tentative proposal. ( 17029088 )
2005
35
Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy. ( 15986373 )
2005
36
[Spondylarthropathies and anti-TNFalpha drugs]. ( 16154026 )
2005
37
Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy: a role for scintigraphy with 99mTc-infliximab. ( 15818709 )
2005
38
Two major spondylarthropathy phenotypes are distinguished by pattern analysis in multiplex families. ( 15818650 )
2005
39
Distribution of HLA-B27 subtypes in Sardinia and continental Italy and their association with spondylarthropathies. ( 16200572 )
2005
40
Late-onset ankylosing spondylitis and related spondylarthropathies: clinical and radiological characteristics and pharmacological treatment options. ( 15974637 )
2005
41
Mesalazine-associated acute tubulointerstitial nephritis in a patient with spondylarthropathy. ( 16222356 )
2005
42
Deltoideal acromial enthesopathy in ankylosing spondylitis and in spondylarthropathies: comment on the article by Lambert et al. ( 16208667 )
2005
43
Genetic control of experimental spondylarthropathy. ( 16059927 )
2005
44
Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathies. ( 16329106 )
2005
45
Anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondylarthropathy. ( 15986366 )
2005
46
Update in spondylarthropathy. ( 14872468 )
2004
47
Magnetic resonance imaging of sacroiliitis in early seronegative spondylarthropathy. Abnormalities correlated to clinical and laboratory findings. ( 13130148 )
2004
48
Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: a prospective study in 154 consecutive patients. ( 15457462 )
2004
49
MRI abnormalities of sacroiliac joints in early spondylarthropathy: a 1-year follow-up study. ( 15513683 )
2004
50
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. ( 15457463 )
2004

Variations for Spondylarthropathy

Expression for Spondylarthropathy

Search GEO for disease gene expression data for Spondylarthropathy.

Pathways for Spondylarthropathy

Pathways related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 B2M LTA TNF
2
Show member pathways
12.39 LTA TLR4 TNF
3
Show member pathways
12.25 LTA TLR4 TNF
4
Show member pathways
12.2 LTA TLR4 TNF
5 11.64 LTA TNF
6 11.58 TLR4 TNF
7 11.55 TLR4 TNF
8
Show member pathways
11.5 LTA TNF
9 11.48 LTA TNF
10 11.45 TLR4 TNF
11
Show member pathways
11.45 LTA TLR4 TNF
12 11.43 CD163 TNF
13 11.38 TLR4 TNF
14 11.31 LTA TLR4 TNF
15
Show member pathways
11.3 B2M TNF
16 11.22 TLR4 TNF
17
Show member pathways
11.13 LTA TNF
18 11.09 TLR4 TNF
19 11.05 TLR4 TNF
20 10.95 LTA TLR4 TNF
21 10.87 TLR4 TNF
22 10.53 LTA TLR4 TNF

GO Terms for Spondylarthropathy

Cellular components related to Spondylarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 B2M TLR4 TNF
2 external side of plasma membrane GO:0009897 8.92 B2M CD163 TLR4 TNF

Biological processes related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.71 CD163 TLR4 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.59 LTA TNF
3 apoptotic signaling pathway GO:0097190 9.58 TLR4 TNF
4 regulation of inflammatory response GO:0050727 9.58 TLR4 TNF
5 positive regulation of JNK cascade GO:0046330 9.57 TLR4 TNF
6 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.56 TLR4 TNF
7 immune response GO:0006955 9.56 B2M LTA TLR4 TNF
8 humoral immune response GO:0006959 9.55 LTA TNF
9 positive regulation of interleukin-6 production GO:0032755 9.52 TLR4 TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.51 TLR4 TNF
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.49 TLR4 TNF
12 positive regulation of interleukin-8 production GO:0032757 9.48 TLR4 TNF
13 negative regulation of interleukin-6 production GO:0032715 9.46 TLR4 TNF
14 positive regulation of NF-kappaB import into nucleus GO:0042346 9.43 TLR4 TNF
15 positive regulation of chemokine production GO:0032722 9.4 TLR4 TNF
16 negative regulation of growth of symbiont in host GO:0044130 9.37 LTA TNF
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.32 TLR4 TNF
18 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.16 LTA TNF
19 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF
20 positive regulation of interferon-gamma production GO:0032729 8.8 LTA TLR4 TNF

Molecular functions related to Spondylarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 LTA TNF

Sources for Spondylarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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