MCID: SPN051
MIFTS: 60

Spondylitis malady

Summaries for Spondylitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

MalaCards: Spondylitis is related to ankylosing spondylitis and arthritis. An important gene associated with Spondylitis is TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Immune System and CDK-mediated phosphorylation and removal of Cdc6. The compounds vegf and infliximab have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and endothelial, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Spondylitis

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

spondylitis 8 44 60


External Ids:

Disease Ontology8 DOID:6590
ICD9CM27 720.8, 720.89

Related Diseases for Spondylitis

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17GeneCards, 18GeneDecks
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Diseases related to Spondylitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 377)
idRelated DiseaseScoreTop Affiliating Genes
1ankylosing spondylitis32.0PTH, NOD2, FCAR, MMP3, TAP2, TAPBP
2arthritis31.2MMP3, IL17A, TNF, TNFSF11, TNFRSF1A
3rheumatoid arthritis31.0NOD2, MMP3, TAP2, IL17A, IL1RN, CD79A
4psoriatic arthritis30.8NOD2, MMP3, CRP, TNF, TNFSF11, TNFRSF1A
5uveitis30.8NOD2, IL17A, HLA-B, TNF, TNFRSF1A, TNFRSF1B
6reactive arthritis30.6TAP2, CD79A, PRTN3, CRP, HLA-B
7crohn's disease30.4NOD2, CRP, TNF, TNFRSF1B
8amyloidosis30.4CD79A, CRP, HLA-B, TNFRSF1A
9psoriasis30.4NOD2, TAP2, TAP1, IL17A, HLA-B, TNF
10pneumonia30.4IL17A, CD79A, CRP, TNF, TNFRSF1B, TLR4
11inflammatory bowel disease30.3NOD2, MMP3, IL17A, IL1RN, PRTN3, CRP
12tuberculosis30.3NOD2, IL17A, CD79A, CRP, TNF, TNFRSF1A
13atherosclerosis30.3NOD2, MMP3, IL17A, IL1RN, CD40LG, PRTN3
14vasculitis30.3IL17A, CD79A, CD40LG, PRTN3, CRP, HLA-B
15glomerulonephritis30.2IL1RN, CD79A, CD40LG, PRTN3
16osteoporosis30.2PTH, MMP3, IL1RN, TNFSF11
17myositis30.2IL1RN, HLA-B, TNFRSF1B
18connective tissue disease30.1CD79A, CD40LG, PRTN3, TNF
19mixed connective tissue disease30.1PRTN3, TNFRSF1B
20familial mediterranean fever30.1TNF, TNFRSF1A
21epidural abscess30.1CRP
22systemic lupus erythematosus30.0NOD2, MMP3, TAP2, TAP1, IL17A, IL1RN
23ulcerative colitis30.0NOD2, MMP3, IL17A, IL1RN, CD79A, PRTN3
24osteoarthritis30.0MMP3, IL17A, IL1RN, CRP, TNF, TNFSF11
25arthropathy30.0NOD2, MMP3, IL1RN, CRP, TNF, TNFSF11
26sarcoidosis30.0NOD2, TAP2, TAP1, IL1RN, TNF, TNFRSF1B
27vascular disease30.0MMP3, IL1RN, TNF, TNFRSF1A
28lupus erythematosus30.0CD79A, CD40LG
29polymyalgia rheumatica30.0IL1RN, CRP
30aortic aneurysm30.0CRP
31leukemia29.9TAP2, TAP1, IL17A, CD79A, CD40LG, PRTN3
32multiple sclerosis29.9TAP2, TAP1, IL17A, IL1RN, HLA-B, TNF
33dermatitis29.9NOD2, IL17A, CD79A, TNFRSF1B
34meningitis29.9CD79A, CRP, HLA-B
35iga glomerulonephritis29.9FCAR, CD79A, CD40LG, PRTN3
36abdominal aortic aneurysm29.9MMP3, TNFRSF1A, TNFRSF1B
37thyroiditis29.9CD79A
38purpura29.9CD79A
39neuropathy29.9CD79A
40myeloid leukemia29.9PRTN3, TLR4
41endocarditis29.9PRTN3
42leishmaniasis29.9TNFRSF1A
43synovitis29.7MMP3, IL17A, IL1RN, CRP, TNF, TNFSF11
44myeloma29.7CD79A, CD40LG, HLA-B, TNFSF11, TNFRSF1A, TNFRSF1B
45periodontitis29.7MMP3, IL17A, IL1RN, TNF, TNFSF11, TLR4
46squamous cell carcinoma29.7MMP3, TAP2, TAPBP, TAP1, PRTN3, HLA-B
47hodgkin's lymphoma29.7IL1RN, HLA-B, PSMB9, TNFRSF1A, TNFRSF1B
48neutropenia29.7IL1RN, PRTN3, TNFRSF1A, TNFRSF1B
49coronary artery disease29.7MMP3, IL17A, CRP, TNFSF11, TNFRSF1B
50proteinuria29.7CD79A, CD40LG, PRTN3, CRP

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to spondylitis

Clinical Features for Spondylitis

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Drugs & Therapeutics for Spondylitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spondylitis

Drug clinical trials:

Search ClinicalTrials for Spondylitis

Search NIH Clinical Center for Spondylitis

Search CenterWatch for Spondylitis

Genetic Tests for Spondylitis

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Anatomical Context for Spondylitis

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32MalaCards
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MalaCards organs/tissues related to Spondylitis:

32
Bone, T cells, Endothelial, Testes, Myeloid, Heart, Whole blood, Eye, Monocytes, Bone marrow, Colon, Thyroid, Pituitary, Skin, Liver, B cells, Lung, Spinal cord, Breast, Brain, Nk cells

Animal Models for Spondylitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spondylitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.2CRP, IL1RN, TAP1, CD40LG, PRTN3, TAPBP
2MP:000539711.9CD79A, IL1RN, NOD2, TAP2, TAPBP, TAP1
3MP:000538411.6TNFRSF1A, TAPBP, CD40LG, TAP1, IL17A, IL1RN
4MP:000537611.5TLR4, TNFRSF1B, TNFSF11, TNF, CRP, IL1RN
5MP:001076811.4TNFSF11, PTH, NOD2, TAP1, IL17A, IL1RN
6MP:000538511.1IL1RN, CD40LG, CRP, TNF, TNFRSF1B, TLR4
7MP:000539011.1TNFSF11, TNFRSF1B, TNFRSF1A, CD40LG, MMP3, NOD2
8MP:001077110.8CD40LG, TNFSF11, TNFRSF1B, TLR4, TAP1
9MP:000200610.5TNF, TNFRSF1A, TAP1, TNFRSF1B

Publications for Spondylitis

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50PubMed
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Articles related to Spondylitis:

(show top 50)    (show all 1301)
idTitleAuthorsYear
1
Genetics of ankylosing spondylitis. (23916070)
2014
2
Autoimmune thyroid disease in ankylosing spondylitis. (24384825)
2014
3
Correlation between clinical outcome and spinopelvic parameters in ankylosing spondylitis. (23900687)
2014
4
Trends of ankylosing spondylitis ossification. (23864924)
2013
5
CT- and fluoroscopy-guided percutaneous screw fixation of a "carrot-stick" spinal fracture in an elderly man with ankylosing spondylitis. (23842576)
2013
6
Health care costs associated with ankylosing spondylitis in Turkey: an analysis from nationwide real-world data. (23509465)
2013
7
Assessing fatigue in ankylosing spondylitis: the importance of frequency and severity. (24307290)
2013
8
Operative Strategy for Different Types of Thoracolumbar Stress Fractures in Ankylosing Spondylitis. (23563333)
2013
9
Is RUNX3 a new player in the pathogenesis of ankylosing spondylitis? (22814793)
2013
10
The effect of physical activity and motivation on function in ankylosing spondylitis: a cohort study. (23351615)
2013
11
Treatment of spinal fractures in ankylosing spondylitis. (24025014)
2013
12
Evaluation of Tp-e interval and Tp-e/QT ratio in patients with ankylosing spondylitis. (23579501)
2013
13
The impact of tumor necrosis factor I+ inhibitors on radiographic progression in ankylosing spondylitis. (23818109)
2013
14
Safety of tumor necrosis factor inhibitors use for rheumatoid arthritis and ankylosing spondylitis in Africa, the Middle East, and Asia: focus on severe infections and tuberculosis. (23242389)
2013
15
Disabling bony ankylosis of hip, knee and axial spine in a neglected patient of ankylosing spondylitis. (23833090)
2013
16
Seasonal disease activity and serum vitamin D levels in rheumatoid arthritis, ankylosing spondylitis and osteoarthritis. (23658567)
2013
17
'Not-belonging': illness narratives of Mexican patients with ankylosing spondylitis. (23944248)
2013
18
Susceptibility to ankylosing spondylitis: evidence for the role of ERAP1, TGFb1 and TLR9 gene polymorphisms. (21833528)
2012
19
Lung parenchymal changes in patients with ankylosing spondylitis. (22761981)
2012
20
Comparison of the clinical expression of patients with ankylosing spondylitis from Europe and Latin America. (23149388)
2012
21
KIR3DL1+HLA-B Bw4Ile80 and KIR2DS1+HLA-C2 combinations are both associated with ankylosing spondylitis in the Iranian population. (21797986)
2011
22
Abnormal high-expression of CD154 on T lymphocytes of ankylosing spondylitis patients is down-regulated by etanercept treatment. (19466423)
2010
23
Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis. (19019897)
2009
24
Re: Zhu et al, "A novel gene variation of TNF alpha associated with ankylosing spondylitis: a reconfirmed study". (18292112)
2008
25
Association of interleukin-23 receptor variants with ankylosing spondylitis. (18383363)
2008
26
HLA-B27 subtypes in Korean patients with ankylosing spondylitis]. (18309255)
2008
27
Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from Chinese ankylosing spondylitis patients with -308G/A polymorphism in promoter region of tumor necrosis factor: association with distinct A33/B58/Cw10 haplotypes. (18719920)
2008
28
Dermatitis herpetiformis in a patient receiving infliximab for ankylosing spondylitis. (18086603)
2008
29
Tumor necrosis factor-alpha blockade leads to decreased peripheral T cell reactivity and increased dendritic cell number in peripheral blood of patients with ankylosing spondylitis. (19004053)
2008
30
Diffuse idiopathic skeletal hyperostosis may give the typical postural abnormalities of advanced ankylosing spondylitis. (17938137)
2007
31
Orbital cellulitis in a patient receiving infliximab for Ankylosing spondylitis. (16564827)
2006
32
Effects of infliximab treatment on lipoprotein profile in patients with rheumatoid arthritis and ankylosing spondylitis. (16541480)
2006
33
Membranous glomerulonephritis complicating ankylosing spondylitis. (16878442)
2006
34
Understanding the role of tumor necrosis factor inhibition in ankylosing spondylitis. (15692960)
2005
35
Efficacy of cyclo-oxygenase-2 inhibition by etoricoxib and naproxen on the axial manifestations of ankylosing spondylitis in the presence of peripheral arthritis. (15731291)
2005
36
Which patients with ankylosing spondylitis should be treated with tumour necrosis factor inhibiting therapy? A survey among Dutch rheumatologists. (15082483)
2004
37
HLA-A*2402 and a microsatellite (D6S248) are secondary independent susceptibility markers to ankylosing spondylitis in Basque patients. (14969772)
2004
38
Anti-TNF-alpha therapy in ankylosing spondylitis. (15212600)
2004
39
Recommendations for starting anti TNF-alpha in patients with ankylosing spondylitis]. (14872220)
2003
40
Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. (11986408)
2002
41
Sulfasalazine in the prevention of anterior uveitis associated with ankylosing spondylitis. (11026996)
2000
42
Neonatal infectious spondylitis of the cervical spine presenting with quadriplegia: a case report. (10828929)
2000
43
Validity aspects of erythrocyte sedimentation rate and C-reactive protein in ankylosing spondylitis: a literature review. (10229429)
1999
44
The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B27 positive juvenile and adult Mexican subjects with ankylosing spondylitis. (9306872)
1997
45
MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane-encoded triplet repeat polymorphism. (9174144)
1997
46
Polymorphism of the LMP2 gene and disease phenotype in ankylosing spondylitis: no association with disease severity. (9348140)
1997
47
Cauda equina syndrome in ankylosing spondylitis: a case report and review of the literature. (7789067)
1995
48
Investigating the genetic basis for ankylosing spondylitis. Linkage studies with the major histocompatibility complex region. (8053961)
1994
49
Pulmonary involvement in collagen vascular disease: a review of the pulmonary manifestations of the Marfan syndrome, ankylosing spondylitis, SjAPgren's syndrome, and relapsing polychondritis. (1578527)
1992
50
Anterior sacral meningocele and tuberculous spondylitis of the sacrum in a patient with neurofibromatosis. Case report and review of the literature. (2518511)
1989

Genetic Variations for Spondylitis

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Expression for genes affiliated with Spondylitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for genes affiliated with Spondylitis

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 55SinoBiological, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Spondylitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.2TLR4, PSMB9, HLA-B, CD40LG, CD79A, IL1RN
2
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11.0TNFRSF1A, TNF, PSMB9, HLA-B, TAP1, TAPBP
3
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11.0TLR4, TNFRSF1A, TNF, HLA-B, TAP1, TAP2
4
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11.0TLR4, TNFRSF1A, TNF, CD40LG, IL17A, NOD2
5
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10.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, TNF, CD40LG
610.9PSMB9, HLA-B, TAP1, TAPBP, TAP2
7
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10.9PSMB9, HLA-B, TAP1, TAPBP, TAP2
810.9FCAR, TAP2, TAP1, HLA-B, TLR4
910.9TNFRSF1B, TNFRSF1A, TNF, MMP3, NOD2
10
Hide members
10.9TNFRSF1B, TNFRSF1A, TNF, HLA-B, CD40LG
11
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10.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, IL17A
12
Hide members
10.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, TNF
1310.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, TNF
14
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.9CD40LG, TNF, TNFSF11, TNFRSF1A, TNFRSF1B
1510.9TLR4, TNFRSF1A, TNFSF11, TNF, CD40LG
16
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10.8HLA-B, TAP1, TAPBP, TAP2
1710.8TAP2, TAP1, CD79A, TNFSF11
1810.8TLR4, TNFRSF1A, TNF, NOD2
19
Hide members
10.8TNFRSF1B, TNFRSF1A, TNFSF11, TNF
2010.8TLR4, TNFRSF1B, TNFRSF1A, TNF
21
Hide members
10.8TLR4, TNFRSF1B, TNFRSF1A, TNF
2210.7PSMB9, HLA-B, TAP1
23
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10.7TAP1, TAPBP, TAP2
24
Development Thrombopoetin signaling via JAK-STAT pathway
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10.7CRP, IL1RN, TAP1
2510.7TNFRSF1A, TNF, NOD2
26
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10.7IL17A, CD79A, CD40LG
27
Hide members
10.7IL17A, TNF, TLR4
28
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10.7TNF, TNFRSF1A, TNFRSF1B
2910.7TNF, TNFRSF1A, TNFRSF1B
30
Apoptosis and survival Apoptotic TNF-family pathways
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10.7TNFRSF1B, TNFRSF1A, TNF
3110.7TNF, TNFRSF1A, TNFRSF1B
32
Hide members
10.7TNFRSF1B, TNFRSF1A, TNF
3310.7TNF, TNFRSF1A, TNFRSF1B
34
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10.7TNFRSF1B, TNFRSF1A, TNF
35
Immune response Bacterial infections in normal airways
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10.7IL1RN, TNF, TLR4
3610.7CD40LG, TNFRSF1A, TNFRSF1B
3710.6TAP1, CD79A
38
Hide members
10.6TNF, TNFRSF1A
39
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.6TNFSF11, PTH
4010.6TNFSF11, TLR4
4110.6TLR4

Compounds for genes affiliated with Spondylitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Spondylitis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1vegf4411.9CD40LG, IL17A, IL1RN, TLR4, PTH, TNFRSF1B
2infliximab44 49 1113.8TLR4, IL17A, MMP3, NOD2, TNFRSF1B, TNFRSF1A
3alanine4411.8CRP, MMP3, IL1RN, CD40LG, CD79A, TNFRSF1A
4retinoic acid44 2412.7CD40LG, CD79A, TLR4, IL1RN, TAPBP, PRTN3
5lipid4411.7HLA-B, TNF, TNFRSF1A, TLR4, TNFRSF1B, CRP
6nitric oxide44 11 2413.7IL1RN, NOD2, PTH, HLA-B, TNFRSF1A, IL17A
7serine4411.6TLR4, NOD2, MMP3, TNF, IL1RN, PRTN3
8methotrexate44 49 1113.6IL17A, MMP3, TNF, IL1RN, CD79A, TNFRSF1B
9creatinine4411.6MMP3, CRP, TNFSF11, TNFRSF1A, CD79A, IL1RN
10etanercept44 49 1113.6TNF, TNFSF11, TNFRSF1A, TNFRSF1B, CRP, IL1RN
11testosterone44 59 11 2414.5HLA-B, PTH, IL1RN, CD79A, CD40LG, TNFRSF1B
12n acetylcysteine4411.5CD40LG, TNFSF11, CRP, CD79A, TNF, MMP3
13sb 20358044 5912.5MMP3, TNF, TLR4, TNFRSF1A, TNFSF11, CRP
14fibrinogen4411.5TNF, IL1RN, CD79A, CD40LG, TNFRSF1B, HLA-B
15ivig4411.5CD79A, CD40LG, IL1RN, CRP, TNF, TNFRSF1A
16neopterin4411.5IL1RN, CD79A, CRP, TNF, TNFRSF1A, TNFRSF1B
17p0024411.4MMP3, TNFRSF1B, IL17A, IL1RN, PRTN3, CRP
18calcium44 49 11 2414.4CRP, PTH, NOD2, TLR4, IL1RN, TAP2
19lactate4411.4MMP3, CD40LG, CD79A, TLR4, CRP, TNF
20rantes4411.4TLR4, TNF, HLA-B, CD40LG, IL17A, TNFRSF1A
21cyclosporin a44 28 5913.4CD40LG, TNFRSF1B, IL17A, CD79A, HLA-B, TNFSF11
22dexamethasone44 49 28 1114.4TNFRSF1B, TLR4, PTH, TNFSF11, CD40LG, CD79A
23sulfasalazine44 28 49 1114.4MMP3, CD79A, TNF, CD40LG, CRP, IL1RN
24chloroquine44 2 49 28 1115.3IL1RN, CD79A, TNF, TNFRSF1B, TLR4, TNFRSF1A
25polyethylene glycol4411.3TNFRSF1B, CRP, CD40LG, CD79A, IL1RN, TNFRSF1A
26oxygen44 2412.3PRTN3, FCAR, TNF, TNFRSF1B, TNFRSF1A, TNFSF11
27adalimumab44 49 1113.3TNF, CRP, CD79A, IL1RN, MMP3
28leflunomide49 44 1113.3TNF, TNFSF11, TNFRSF1A, MMP3, IL1RN
29tyrosine4411.2HLA-B, TNFSF11, TNFRSF1A, PTH, FCAR, MMP3
30okt34411.2TNFRSF1A, TNF, CD79A, CRP, CD40LG
31ns 39844 5912.2TNFRSF1A, TNFSF11, IL17A, TNF, IL1RN
32vitamin d4411.2TNFRSF1B, TNFSF11, CD79A, MMP3, TLR4, PTH
33simvastatin44 49 59 28 11 2416.2CRP, IL1RN, TNFRSF1A, MMP3, TNF, TLR4
34mannose4411.2TLR4, NOD2, CD79A, FCAR, IL17A, IL1RN
35il 104411.2NOD2, TNF, TNFRSF1B, IL1RN, TLR4
36peptidoglycan44 2812.1TLR4, NOD2, TNFSF11, TNF, IL1RN
37prednisolone44 28 1113.1CRP, CD79A, MMP3, NOD2
38pneumococcal4411.1TLR4, HLA-B, CD40LG, CD79A
39prostaglandin4411.1MMP3, IL17A, TNFSF11, TNF, IL1RN, PTH
40superoxide44 2412.1TNFRSF1B, TNF, FCAR, TNFRSF1A
41blys4411.1TNFRSF1A, TNF, CD40LG, CD79A
42endotoxin4411.1TNFRSF1B, TNFRSF1A
43rituximab44 49 1113.1TNF, CD79A, CD40LG, PRTN3, CRP
44estrogen4411.0TNFRSF1B, CD79A, PRTN3
45cycloheximide4411.0PTH
46fmlp4410.9TNFRSF1B, PRTN3, IL1RN
47h2o24410.9TNFRSF1B, TNFRSF1A, CD79A, IL1RN
48tacrolimus44 49 1112.8IL17A, TNFSF11, CD79A
49pmma4410.8CD79A, CD40LG, TNFSF11, CRP
50forskolin44 49 1112.3TAP2, PTH

GO Terms for genes affiliated with Spondylitis

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Sources:
16Gene Ontology
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Cellular components related to Spondylitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.7CD40LG, IL1RN, TLR4, TNFRSF1B, TNFRSF1A, TNF
2extracellular spaceGO:00561511.3CD40LG, TNFRSF1A, TNFSF11, TNF, CRP, IL1RN
3integral to plasma membraneGO:00588711.0TNF, FCAR, CD40LG, HLA-B, TNFRSF1A, TNFSF11
4external side of plasma membraneGO:00989710.9CD40LG, TLR4, TNF, CD79A, IL17A
5extracellular regionGO:00557610.8TNFRSF1B, FCAR, MMP3, CRP, TNF, TNFSF11
6TAP complexGO:04282510.8TAP1, TAPBP, TAP2
7membrane raftGO:04512110.7CD79A, TNF, TNFRSF1A, TNFRSF1B

Biological processes related to Spondylitis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.5HLA-B, TNFRSF1B, IL1RN, IL17A, TAPBP, FCAR
2inflammatory responseGO:00695411.3IL17A, TNFRSF1B, TNFRSF1A, TNF, CRP, CD40LG
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247911.3TAP2, TAP1, HLA-B, TAPBP, PSMB9
4antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259011.3TAP2, TAPBP, TAP1, HLA-B, PSMB9
5antigen processing and presentation of peptide antigen via MHC class IGO:00247411.3TAP2, PSMB9, HLA-B, TAP1, TAPBP
6positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312311.2TNFRSF1A, TLR4, NOD2, TNF, TNFSF11
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.2TLR4, TNFRSF1A, TNFSF11, TNF, IL17A, PTH
8positive regulation of JNK cascadeGO:04633011.2NOD2, TNF, TLR4, TNFSF11
9defense responseGO:00695211.1NOD2, TAPBP, TAP1, HLA-B
10positive regulation of NF-kappaB transcription factor activityGO:05109211.1NOD2, TNFSF11, TNF, TLR4
11antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988511.1TAP1, TAPBP, TAP2
12positive regulation of osteoclast differentiationGO:04567211.1TNF, TNFSF11, IL17A
13positive regulation of T cell mediated cytotoxicityGO:00191611.0TAP1, TAP2, HLA-B
14negative regulation of interleukin-6 productionGO:03271511.0TNFRSF1A, TLR4, TNF
15positive regulation of interleukin-12 productionGO:03273511.0NOD2, CD40LG, TLR4
16positive regulation of tumor necrosis factor productionGO:03276011.0TLR4, TNFRSF1A, NOD2
17defense response to Gram-positive bacteriumGO:05083011.0CRP, NOD2, TNF
18positive regulation of interleukin-6 productionGO:03275511.0NOD2, TNF, TLR4
19cytosol to ER transportGO:04696710.9TAP1, TAP2
20chronic inflammatory response to antigenic stimulusGO:00243910.9TNF, IL1RN
21regulation of immunoglobulin secretionGO:05102310.8CD40LG, TNF
22intracellular transport of viral proteins in host cellGO:01906010.8TAP2, TAP1
23peptide transportGO:01583310.8TAP2, TAP1
24positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8NOD2, TNF
25activation of MAPK activityGO:00018710.7NOD2, TLR4, TNF
26negative regulation of lipid storageGO:01088810.7CRP, TNF
27positive regulation of interleukin-8 biosynthetic processGO:04541610.6TNF, TLR4
28positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.5NOD2, TLR4
29B cell proliferationGO:04210010.3CD79A, CD40LG

Molecular functions related to Spondylitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:04260511.0TAPBP, TAP1, HLA-B, TAP2
2TAP1 bindingGO:04697811.0TAPBP, TAP1, TAP2
3TAP2 bindingGO:04697910.9TAP1, TAPBP, TAP2
4MHC class I protein bindingGO:04228810.9TAPBP, TAP1, TAP2
5tumor necrosis factor receptor bindingGO:00516410.9TNFSF11, TNF, CD40LG
6peptide antigen-transporting ATPase activityGO:01543310.8TAP2, TAPBP
7tapasin bindingGO:04698010.7TAP2, TAP1
8peptide transporter activityGO:01519710.6TAP1, TAP2
9tumor necrosis factor-activated receptor activityGO:00503110.6TNFRSF1B, TNFRSF1A
10oligopeptide-transporting ATPase activityGO:01542110.5TAP1, TAP2
11cytokine activityGO:00512510.5IL17A, CD40LG, TNF, TNFSF11

Products for genes affiliated with Spondylitis

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Sources for Spondylitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet