Spondylitis malady

Wikipedia: Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis...⁴⁴ more...

MalaCards: Spondylitis is related to ankylosing spondylitis and arthritis. An important gene associated with Spondylitis is TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Immune System and Antigen processing and presentation. The compounds ionomycin and hydroxyapatite have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, skeletal muscle and colon, and related mouse phenotypes are craniofacial and respiratory system.

Aliases & Descriptions:

spondylitis 6 8 32 43

Diseases related to spondylitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 991)

id	Related Disease	Score	Top Affiliating Genes
1	ankylosing spondylitis	43.1	SERPINA1, BGLAP, CD79A, CD40LG, MMP3, FCAR
2	arthritis	35.4	SERPINA1, VIP, MMP3, IL17A, IL1A, IL1B
3	rheumatoid arthritis	35.2	CHI3L1, IL1R1, IL1R2, IL1RN, HLA-DRB1, TNFRSF1A
4	reactive arthritis	32.0	BSG, CD79A, HSPD1, HP, HLA-B, CRP
5	psoriatic arthritis	32.0	IL10, IL1B, IL1RAPL2, IL1RN, IL6, TNF
6	klebsiella	31.5	MPO, CD79A, CD40LG, INS, IL17A, IL1B
7	crohn's disease	30.5	BMP7, CHI3L1, MPO, IL10, IL12B, IL17A
8	spondyloarthropathy	30.4	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
9	ankylosis	30.0	BMP2, ENPP1, ANKH, ERAP1, HLA-B, TNFRSF11B
10	spondylarthropathy	29.9	S100A8, IL1RAPL2, TNF, CRP, TLR4
11	anterior uveitis	29.0	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
12	tuberculosis	28.9	VDR, IL10, IL12B, IL1B, IL1RN, IL4
13	behcet's disease	28.9	KIR2DL1, KIR3DL1, LBR, MEFV, APOH, CCR5
14	iritis	28.5	MRAP, CD79A, CD40LG, HLA-B
15	ulcerative colitis	28.5	SERPINA1, VIP, BGLAP, CHI3L1, CHKB, MPO
16	osteomalacia	28.5	GC, VDR, BGLAP, CD36, GSTP1, ENPP1
17	osteopenia/osteoporosis	28.4	BGLAP, CD36, IGF1, CALCA, TNFRSF11B, TNFSF11
18	familial mediterranean fever	28.3	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
19	inflammatory bowel disease	27.2	SERPINA1, VIP, VDR, BMP7, BGLAP, CHI3L1
20	autonomic dysfunction	26.9	INS, IL6, APOA1, ALB, CRP, RPS27A
21	retinol binding protein	26.9	LEP, INS, APOA1, CCL2, ALB, HSPA5
22	antiphospholipid syndrome	26.5	VWF, VEGFA, CD79A, CD40LG, APOH, IGF1
23	breast cancer	25.8	VEGFA, VDR, MMP1, MMP3, GSTP1, IL10
24	systemic lupus erythematosus	25.7	PDCD1, VWF, VIP, PADI4, CHI3L1, LBR
25	uveitis	25.3	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
26	neutropenia	25.0	MPO, JAK2, CD79A, CD14, CD40LG, IL10
27	hypoglycemia	24.5	GCKR, VEGFA, LEP, CHKB, CD79A, CD36
28	cutaneous leishmaniasis	24.2	BMP6, IL10, IL12B, IL17A, IL4, IL6
29	osteoporosis	23.9	GC, VEGFA, VDR, BMP2, BMP4, BMP6
30	synovitis	23.9	SERPINA1, VEGFA, BGLAP, S100A8, MRAP, MPO
31	pneumonia	23.2	RELA, SERPINA1, BSG, VEGFA, BMP6, BGLAP
32	blindness	21.9	VWF, VIP, VEGFA, VDR, BGLAP, LEP
33	leishmaniasis	21.5	RELA, BMP6, JAK2, GSR, IL10, IL12B
34	vasculitis	21.2	PDCD1, VWF, SERPINA1, VEGFA, BMP6, MPO
35	psoriasis	20.8	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
36	duodenitis	20.8	VIP, VDR, LEP, S100A8, MPO, CD79A
37	insulin resistance	20.3	RELA, VWF, GCKR, VEGFA, VDR, BMP6
38	nephropathy	19.4	ZNF365, PDCD1, RELA, VWF, SERPINA1, VEGFA
39	lupus erythematosus	18.3	PDCD1, PDCD1LG2, KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1
40	birdshot chorioretinopathy	14.3	KIR2DS3, KIR2DL1, KIR3DS1, KIR2DS4, KIR3DL1, KIR2DS2
41	hyper-igd syndrome	14.3	SAA1, IL1RN, TNF, TNFRSF1A, CRP
42	vogt-koyanagi-harada disease	14.3	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
43	multicentric reticulohistiocytosis	14.2	CD68, TNF, TNFRSF11B, TNFSF11, CSF1
44	dermatitis herpetiformis	14.2	CD79A, CD40LG, MMP3, FBN1, ICAM1, HLA-DQA1
45	trachoma	14.2	CD79A, IL10, IL17A, IL4, HSPD1, HP
46	schnitzler syndrome	14.2	CD40LG, IL1A, IL1R1, IL1RAPL2, IL1RN, TNF
47	hypophosphatasia	14.2	IL1R1, ENPP1, ANKH, CCL27, ALPL, ALPP
48	villonodular synovitis	14.1	BGLAP, CD68, MMP1, IBSP, TNFRSF11B, TNFSF11
49	mhc class i deficiency	14.1	IFNG, HLA-B, TAPBP, TAP1, TAP2
50	pigmented villonodular synovitis	14.1	BGLAP, CD68, MMP1, IBSP, TNFRSF11B, TNFSF11

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spondylitis:

²²

MGI Mouse Phenotypes related to spondylitis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.9	BMP4, LBR, MSX2, FLNB, IL12B, IL17A
2	respiratory system phenotype	MP:0005388	10.8	CD14, IL12B, FBN1, ANKH, CCR4, ALPL
3	hematopoietic system phenotype	MP:0005397	10.6	PDCD1, PDCD1LG2, BMP4, KDM5A, MST1, MSX2
4	immune system phenotype	MP:0005387	10.1	VWF, BSG, VDR, PADI4, KDM5A, LBR
5	endocrine/exocrine gland phenotype	MP:0005379	10.0	KDM5A, MSX2, ATG16L1, CDKAL1, CD40LG, IL2
6	other phenotype	MP:0005395	9.9	JAK2, CD40LG, IL2, FBN1, ENPP1, ANKH
7	renal/urinary system phenotype	MP:0005367	9.8	PDCD1, BMP4, BMP7, INS, FBN1, HSPA5
8	limbs/digits/tail phenotype	MP:0005371	9.8	RELA, VEGFA, VDR, VCAN, BMP2, BMP4
9	hearing/vestibular/ear phenotype	MP:0005377	9.7	VDR, BMP2, BMP4, BMP7, MSX2, IL22
10	integument phenotype	MP:0010771	9.5	RELA, LBR, MSX2, CD274, GSTP1, MEFV
11	no phenotypic analysis	MP:0003012	9.4	PDCD1LG2, VEGFA, BMP4, LBR, CD79A, CD274
12	liver/biliary system phenotype	MP:0005370	9.2	VEGFA, BMP4, MST1, CD36, INS, MEFV
13	nervous system phenotype	MP:0003631	8.9	PDCD1, RELA, VWF, VCAN, BMP2, BMP4
14	digestive/alimentary phenotype	MP:0005381	8.6	VWF, VEGFA, VDR, BMP2, BMP4, BMP7
15	adipose tissue phenotype	MP:0005375	8.4	LEP, LBR, CD36, CD14, INS, IL1R1
16	growth/size phenotype	MP:0005378	8.3	RELA, BSG, VDR, BMP2, BMP4, BMP6
17	reproductive system phenotype	MP:0005389	8.2	VIP, VEGFA, VDR, BMP2, BMP7, LEP
18	skeleton phenotype	MP:0005390	8.0	RELA, GC, VEGFA, VDR, VCAN, BMP2
19	mortality/aging	MP:0010768	8.0	PDCD1, PDCD1LG2, RELA, VWF, BSG, VEGFA
20	behavior/neurological phenotype	MP:0005386	7.9	VIP, BMP4, KDM5A, LEP, CHKB, LBR
21	muscle phenotype	MP:0005369	7.7	PDCD1, RELA, VEGFA, BMP4, LEP, CHKB
22	tumorigenesis	MP:0002006	7.5	PDCD1LG2, KDM5A, LEP, JAK2, GSTP1, IL10
23	vision/eye phenotype	MP:0005391	7.5	PDCD1, RELA, VEGFA, BMP4, BMP7, LEP
24	normal phenotype	MP:0002873	7.1	RELA, VIP, VEGFA, VCAN, BMP2, BMP4
25	cardiovascular system phenotype	MP:0005385	6.7	PDCD1, RELA, VWF, VEGFA, VDR, BMP2
26	cellular phenotype	MP:0005384	6.6	PDCD1, PDCD1LG2, RELA, VWF, VEGFA, VDR
27	homeostasis/metabolism phenotype	MP:0005376	5.2	PDCD1LG2, RELA, VWF, GCKR, GC, VIP

Articles related to spondylitis:

(show top 50)    (show all 402)

id	Title	Authors	Year	Affiliating Genes
1	Increased serum IL-17 and IL-23 in the patient with a nkylosing spondylitis. (21161669)	Mei Y.... Ye D.	2011	IL17A, IL23A
2	Association of polymorphisms in the programmed cell d eath 1 (PD-1) and PD-1 ligand genes with ankylosing spondylitis in a Chinese po pulation. (21269571)	Yang Q.... Mu K.	2011	PDCD1, CD274
3	Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. (19804562)	Liu Y.... Xu H.	2010	HLA-B
4	Anti-TNF-alpha Therapy for Ankylosing Spondylitis. (20190998)	Son J.H.... Cha S.W.	2010	TNF
5	Increased expression of carbonic anhydrase I in the s ynovium of patients with ankylosing spondylitis. (21143847)	Chang X.... Cui Y.	2010	CA1
6	Serum cytokine receptors in ankylosing spondylitis: r elationship to inflammatory markers and endoplasmic reticulum aminopeptidase po lymorphisms. (20595269)	Haroon N.... Inman R.D.	2010	ERAP1, ERAP2
7	Association of the KIR3DS1*013 and KIR3DL1*004 allele s with susceptibility to ankylosing spondylitis. (20131260)	DA-az-PeA+a R.... LA^pez-Larrea C.	2010	KIR3DL1, KIR3DS1
8	HLA-B, DR and DQ antigens polymorphism in Tunisian pa tients with ankylosing spondylitis (a case-control study). (19655145)	Kchir M.M.... Makni S.	2010	HLA-DQB1, HLA-DRB1, HLA-B
9	Association of ARTS1 gene polymorphisms with ankylosi ng spondylitis in the Hungarian population: the rs27044 variant is associated w ith HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis. (20032103)	PazA!r B.... PoA^r G.	2010	TNFRSF1A, ERAP1, HLA-B
10	Improvement in hemoglobin levels in patients with ank ylosing spondylitis treated with infliximab. (19644896)	Braun J.... Rahman M.U.	2009	CRP
11	Effects of balneotherapy on the reactants of acute i nflammation phase in ankylosing spondylitis (19594066)		2009	CRP
12	Increased levels of asymmetric dimethylarginine (ADMA ) in patients with ankylosing spondylitis. (19687580)	Sari I.... Kozaci D.L.	2009	CRP, EDN1
13	Distribution of HLA-B27 and its alleles in patients with reactive arthritis and with ankylosing spondylitis in Tunisia. (19152094)	Siala M.... Makni H.	2009	HLA-B
14	ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis. (19060001)	van der Heijde D.... LandewAc R.	2009	CRP
15	Erythrocyte sedimentation rate, C-reactive protein le vel, and serum amyloid a protein for patient selection and monitoring of anti-t umor necrosis factor treatment in ankylosing spondylitis. (19877087)	de Vries M.K.... Wolbink G.J.	2009	CRP
16	Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy. (18674944)	Wendling D.... Racadot E.	2008	MMP3, TNF, CTSK
17	Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns. (18634146)	Pointon J.J.... Wordsworth B.P.	2008	TLR4, CD14
18	Six-month response to anti-TNF drugs in axial spondylarthropathy according to the fulfillment or not of New-York criteria for ankylosing spondylitis or French recommendations for anti-TNF use. A 'real life' retrospective study on 175 patients. (18848489)	GAcrard S.... Berthelot J.M.	2008	CRP
19	Single nucleotide polymorphism of COL6A1 in patients with ankylosing spondylitis. (18634150)	Kim T.H.... Jun J.B.	2008	COL6A1
20	The rate and significance of Mediterranean fever gene mutations in patients with ankylosing spondylitis: a three-month, longitudinal clinical study. (18597091)	Cinar M.... Gul D.	2008	MEFV
21	IL1RN*2 allele of IL-1receptor antagonist VNTR polymorphism is associated with susceptibility to ankylosing spondylitis in Indian patients. (17899305)	Agrawal S.... Aggarwal A.	2008	IL1RN
22	Clinical features of ankylosing spondylitis may correlate with HLA-B27 polymorphism. (18953540)	Wu Z.... Gu J.	2008	HLA-B
23	MRI in predicting a major clinical response to anti-tumour necrosis factor treatment in ankylosing spondylitis. (18006539)	Rudwaleit M.... Sieper J.	2008	TNF
24	Switching tumour necrosis factor alpha antagonists in patients with ankylosing spondylitis and psoriatic arthritis: an observational study over a 5-year period. (17613555)	Conti F.... Valesini G.	2007	TNF
25	Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis. (17476615)	Park M.C.... Lee S.K.	2007	LEP, LSL
26	An evaluation of anti-TNF-alpha-therapy in patients with ankylosing spondylitis: imbalanced activation of NF kappa B subunits in lymphocytes and modulation of serum cortisol concentration. (17242904)	Eggert M.... Neeck G.	2007	NFKB1, IL6, RELA
27	Intracellular cytokine patterns in Behcet's disease in comparison to ankylosing spondylitis--influence of treatment with interferon-alpha2a. (17949552)	Amberger M.... Kotter I.	2007	IL2
28	Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations. (16805919)	Lopez-Larrea C.... Martinez-Borra J.	2006	KIR3DL1, KIR3DS1
29	Imaging in ankylosing spondylitis. (16777579)	Maksymowych W.P.... LandewAc R.	2006	TNF
30	Effects of infliximab treatment on lipoprotein profile in patients with rheumatoid arthritis and ankylosing spondylitis. (16541480)	Kiortsis D.N.... Drosos A.A.	2006	TNF
31	Antinuclear, anti-dsDNA and anti-ENA antibodies in patients affected with rheumatoid arthritis or ankylosing spondylitis during treatment with infliximab (16829990)	Hoxha A.... Todesco S.	2006	CRP
32	Validation of the Italian versions of the Bath Ankylosing Spondylitis Functional Index (BASFI) and the Dougados Functional Index (DFI) in patients with ankylosing spondylitis (16258600)	Salaffi F.... Grassi W.	2005	CRP
33	BSR guidelines for prescribing TNF-alpha blockers in adults with ankylosing spondylitis. Report of a working party of the British So ciety for Rheumatology. (15901904)	Keat A.... Wordsworth P.	2005	TNF
34	Late-onset ankylosing spondylitis and related spondylarthropathies: clinical and radiological characteristics and pharmacological treatment options. (15974637)	Toussirot E.... Wendling D.	2005	TNF
35	Efficacy of anakinra in active ankylosing spondylitis: a clinical and magnetic resonance imaging study. (15066864)	Tan A.L.... McGonagle D.	2004	IL1R1
36	Anti-TNF-alpha therapy in ankylosing spondylitis. (15212600)	Wendling D.... Toussirot E.	2004	TNFRSF1B
37	HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients. (15113995)	Wei J.C.... Chou C.T.	2004	HLA-A, HLA-B
38	HLA-B27 in the Greek Cypriot population: distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707. (15603872)	Varnavidou-Nicolaidou A.... Kyriakides G.	2004	HLA-B
39	Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis. (12730543)	Zou J.... Sieper J.	2003	ACAN
40	Increased osteoprotegerin and decreased pyridinoline levels in patients with ankylosing spondylitis: comment on the article by GratacA^s et al. (12483748)	Golmia R.P.... Scheinberg M.A.	2002	TNFRSF11B
41	Variation in HLA-B27 gene subtypes and susceptibility of ankylosing spondylitis in the Croatian population (12476735)	Grubic Z.... Kastelan A.	2001	HLA-B
42	Positive association of ankylosing spondylitis with homozygous HLA-B2704, but protection with B2705 in Taiwan Chinese. (11831114)	Shih H.C.... Chang J.G.	2001	HLA-B
43	Clinical relevance of C-reactive protein in axial involvement of ankylosing spondylitis. (10229430)	Dougados M.... Calin A.	1999	CRP
44	Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative caucasian patients with ankylosing spondylitis. (9952031)	Yabuki K.... Inoko H.	1999	HLA-B
45	Polymorphism in the LMP2 gene influences the relative risk for acute anterior uveitis in unselected patients with ankylosing spondylitis. (7768065)	Maksymowych W.P.... Russell A.S.	1995	PSMB9
46	TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. (8770637)	Westman P.... Koskimies S.	1995	TAP1, TAP2
47	Analysis of the MHC class II encoded components of the HLA class I antigen processing pathway in ankylosing spondylitis. (8311558)	Burney R.O.... Wordsworth B.P.	1994	FLNB, PSMB9
48	Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis. (1352961)	Higgins C.M.... Craig R.K.	1992	HLA-B
49	Bone marrow IgA and IgA subclass synthesis in ankylosing spondylitis. (1613704)	Peeters A.J.... Breedveld F.C.	1992	CD79A
50	Association of RFLP of HLA class I genes with Chinese ankylosing spondylitis patients. (2576476)	Lin X.Y.... Chen S.S.	1989	HLA-B

Genes related to spondylitis according to GeneCards:

(show top 50)    (show all 212)

id	Symbol	Description	Score	GeneCards Section Context
1	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.1	Publications, Summaries
2	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.1	Publications, Summaries
3	HLA-B	major histocompatibility complex, class I, B	11.0	Aliases & Descriptions, Publications
4	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
5	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	11.0	Publications
6	TAPBP	TAP binding protein (tapasin)	11.0	Publications
7	FCAR	Fc fragment of IgA, receptor for	11.0	Publications
8	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0	Publications
9	PTH	parathyroid hormone	11.0	Publications
10	PRTN3	proteinase 3	11.0	Publications
11	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
12	IL17A	interleukin 17A	11.0	Publications
13	ANKH	ankylosis, progressive homolog (mouse)	11.0	Publications
14	TGIF1	TGFB-induced factor homeobox 1	11.0	Publications
15	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
16	CRP	C-reactive protein, pentraxin-related	11.0	Publications
17	ACAN	aggrecan	11.0	Publications
18	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
19	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
20	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
21	IL1R1	interleukin 1 receptor, type I	11.0	Publications
22	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
23	CD40LG	CD40 ligand	11.0	Publications
24	FBN1	fibrillin 1	11.0	Publications
25	TNF	tumor necrosis factor	11.0	Publications
26	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
27	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
28	HP	haptoglobin	11.0	Publications
29	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
30	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
31	HSPA8	heat shock 70kDa protein 8	11.0	Publications
32	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0	Publications
33	TLR4	toll-like receptor 4	11.0	Publications
34	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
35	KIR2DP1	killer cell immunoglobulin-like receptor, two domains, pseudogene 1	11.0	Publications
36	IL36A	interleukin 36, alpha	11.0	Publications
37	IL1F10	interleukin 1 family, member 10 (theta)	11.0	Publications
38	ERAP1	endoplasmic reticulum aminopeptidase 1	11.0	Publications
39	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	11.0	Publications
40	IL37	interleukin 37	11.0	Publications
41	KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	11.0	Publications
42	MUC19	mucin 19, oligomeric	11.0	Publications
43	NKX2-3	NK2 homeobox 3	11.0	Publications
44	IRGM	immunity-related GTPase family, M	11.0	Publications
45	IL36G	interleukin 36, gamma	11.0	Publications
46	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	11.0	Publications
47	CREG1	cellular repressor of E1A-stimulated genes 1	11.0
48	MRAP	melanocortin 2 receptor accessory protein	11.0
49	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications
50	ORMDL3	ORM1-like 3 (S. cerevisiae)	11.0	Publications

Pathways related to spondylitis according to GeneDecks:

(show top 50)    (show all 154)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	11.3	PDCD1, PDCD1LG2, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3
2	Antigen processing and presentation20	11.2	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
3	Natural killer cell mediated cytotoxicity20	10.9	KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4
4	Graft-versus-host disease20	10.6	KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5A, KIR2DL2
5	RAR-Gamma-RXR-Alpha Degradation36	10.5	BMP2, BMP4, BMP7, IL2, IL22, IL23A
6	Cellular Transformation by HTLV136	10.5	RELA, JAK2, IFNG, HSPA1A, HSPA1B, HSPA8
7	TRAF Pathway36	10.3	IL12B, IL1A, IL1B, IL1R1, TRADD, TNF
8	Akt Signaling36	10.3	BMP2, BMP4, BMP7, IL10, IL12B, IL2
9	Intestinal immune network for IgA production20	10.2	CD40LG, ITGB7, IL10, IL2, IL4, IL6
10	Th17 Differentiation37	10.1	JAK2, IL12B, IL17A, IL1B, IL1R1, IL22
11	Cytokine production by Th17 cells in CF41	10.0	RELA, JAK2, CD14, IL12B, IL17A, IL23A
12	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.9	VDR, BGLAP, IL1A, IL1B, IL6, IGF1
13	Allograft rejection20	9.9	CD40LG, IL10, IL12B, IL2, IL4, IFNG
14	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.9	VDR, BGLAP, IL1A, IL1B, IL6, IGF1
15	Cytokine production by Th17 cells in CF (Mouse model)41	9.9	RELA, JAK2, CD14, IL12B, IL17A, IL23A
16	Influenza A20	9.8	RELA, JAK2, IL12B, IL1A, IL1B, IL6
17	Molecular Mechanisms of Cancer36	9.8	BMP2, BMP4, BMP6, BMP7, ITGB7, IL12B
18	PGC1Alpha Pathway36	9.8	BMP2, BMP4, BMP6, BMP7, IL12B, IL1A
19	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	IL12B, IL17A, IL1B, IL22, IL23A, IL23R
20	Toxoplasmosis20	9.7	RELA, JAK2, CD40LG, IRGM, IL10, IL12B
21	Type I diabetes mellitus20	9.7	INS, IL12B, IL1A, IL1B, IL2, IFNG
22	Measles20	9.7	RELA, JAK2, IL12B, IL1A, IL1B, IL2
23	IL-6 Pathway36	9.5	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
24	Rheumatoid arthritis20	9.4	VEGFA, MMP1, MMP3, IL17A, IL1A, IL1B
25	Tuberculosis20	9.4	RELA, VDR, JAK2, CD14, IL10, IL12B
26	Immune response MIF-mediated glucocorticoid regulation10	9.3	RELA, MMP1, IL2, IL6, IFNG, ICAM1
27	Immune response_MIF-mediated glucocorticoid regulation41	9.3	RELA, MMP1, IL2, IL6, IFNG, ICAM1
28	NFAT Signaling and Lymphocyte Interactions36	9.2	BMP2, BMP4, BMP6, BMP7, IL12B, IL1A
29	Endothelin-1 Signaling Pathway36	9.2	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
30	NF-KappaB (p50-p65) Pathway36	9.2	RELA, BMP2, BMP4, BMP6, BMP7, IL1A
31	NF-KappaB Family Pathway36	9.2	RELA, BMP2, BMP4, BMP6, BMP7, IL1A
32	STAT3 Pathway36	9.1	BMP2, BMP4, BMP6, BMP7, JAK2, IL10
33	Leishmaniasis20	9.1	RELA, JAK2, IL10, IL12B, IL1A, IL1B
34	all-trans-Retinoic Acid Signaling in Brain36	9.1	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
35	Cytokine-cytokine receptor interaction20	9.0	VEGFA, BMP2, BMP7, LEP, CD40LG, IL10
36	TGF-Beta Pathway36	9.0	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
37	PEDF Induced Signaling36	9.0	RELA, BMP2, BMP4, BMP6, BMP7, IL10
38	Malaria20	9.0	CD36, CD40LG, IL10, IL1B, IL6, CCL2
39	MAPK Family Pathway36	8.9	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
40	Glucocorticoid Receptor Signaling36	8.9	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
41	MIF Regulation of Innate Immune Cells36	8.9	BMP2, BMP4, BMP6, BMP7, CD14, IL10
42	SOCS Pathway36	8.9	BMP2, BMP4, BMP6, BMP7, JAK2, INS
43	PAK Pathway36	8.8	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
44	p38 Signaling36	8.7	BMP2, BMP4, BMP6, BMP7, IL10, IL12B
45	MIF Mediated Glucocorticoid Regulation36	8.7	BMP2, BMP4, BMP6, BMP7, CD14, IL10
46	Tec Kinases Signaling36	8.7	BMP2, BMP4, BMP6, BMP7, JAK2, ITGB7
47	ERK Signaling36	8.7	BMP2, BMP4, BMP6, BMP7, ITGB7, IL10
48	Rho Family GTPases36	8.7	BMP2, BMP4, BMP6, BMP7, ITGB7, IL10
49	Antioxidant Action of Vitamin-C36	8.5	BMP2, BMP4, BMP6, BMP7, JAK2, FLNB
50	JAK-STAT Pathway36	8.3	BMP2, BMP4, BMP6, BMP7, JAK2, IL10

Compounds related to spondylitis according to GeneDecks:

(show top 50)    (show all 433)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.9	CD274, HSPA5, TNFRSF1A, NFKBIA
2	hydroxyapatite32	10.8	BMP2, BMP7, BGLAP, CD36, ENPP1, ANKH
3	25-hydroxyvitamin d32	10.6	GC, VDR, BGLAP, LEP, ALPP, HSPA8
4	polyethylene glycol32	10.4	VIP, BMP2, CHKB, MPO, APOA1, ALPP
5	ns 39832 42	11.3	BGLAP, MMP1, IL17A, IL1A, IL1B, TNF
6	gp 13032	10.3	VIP, BMP4, BMP6, JAK2, IL1R1, HP
7	lipoteichoic acid32	10.3	CD14, IL10, IL12B, IL1B, IL1R1, IL1RN
8	homocysteine32 18	11.1	VWF, CD14, IL1R1, FBN1, APOA1, APOH
9	pamidronate32 9 9	12.1	BGLAP, CD36, MMP1, IL10, IL6, ALPP
10	prostaglandin32	10.1	VIP, MMP1, MMP3, IL17A, IL1A, IL1B
11	estradiol32 9 18 9	13.0	GC, CHKB, SAA1, IL1R1, ESR1, TNFRSF11B
12	raloxifene32 9 9	11.8	VWF, VDR, BMP2, BGLAP, CHKB, CD36
13	oxygen32 18	10.8	SERPINA1, BMP2, CHKB, S100A8, MPO, JAK2
14	corticosterone32 18	10.8	VIP, BGLAP, MPO, IL1A, IL1B, IL1R1
15	iron32 18	10.7	SERPINA1, BMP4, MPO, ITLN1, MMP3, IL1R1
16	rapamycin32 42	10.7	VEGFA, BMP2, BMP4, JAK2, INS, IL1R1
17	budesonide32 42 9 9	12.6	BGLAP, CD36, IGHE, NR3C1, LTF
18	polyacrylamide32	9.6	GC, SERPINA1, VCAN, BMP2, CHKB, S100A8
19	cysteine32	9.5	KIR2DS4, SERPINA1, VDR, BMP4, BGLAP, CHKB
20	n acetylcysteine32	9.5	VWF, JAK2, CD79A, MMP1, MMP3, IL1R1
21	ccl332	9.5	IL10, IL1A, IL1B, IL1R1, IL6, CCL7
22	alginate32	9.5	VCAN, BMP2, BMP7, BGLAP, CD79A, CD36
23	etanercept32 9 9	11.3	LEP, MMP1, MMP3, IL10, IL17A, IL1B
24	heparin32 9 18 9	12.2	VWF, SERPINA1, BSG, VCAN, BMP4, BGLAP
25	testosterone32 9 18 9	12.2	RELA, GC, VIP, VDR, BMP2, BGLAP
26	triptolide32	9.1	VEGFA, CD14, MMP3, IL1B, IL2, IL6
27	aspartate32	9.0	GC, VIP, VDR, BMP6, CHKB, CD14
28	ly29400232	9.0	VEGFA, LEP, IL10, IL17A, IL1B, IL4
29	infliximab32 9 9	11.0	VEGFA, BGLAP, LBR, MMP1, MMP3, IL10
30	dihydrotestosterone32 9 18 9	11.8	VIP, VDR, BMP2, BMP6, BGLAP, LEP
31	nitric oxide32 9 18 9	11.7	SERPINA1, BMP2, BMP4, BMP6, CHI3L1, CHKB
32	paraffin32	8.6	RELA, VWF, SERPINA1, VEGFA, BGLAP, LEP
33	tamoxifen32 34 9 9	11.6	VEGFA, VDR, BMP6, BGLAP, LEP, CHKB
34	phosphatidylinositol32	8.6	BMP4, BMP6, LEP, JAK2, CD14, INS
35	tacrolimus32 34 9 9	11.4	VDR, BMP2, BMP6, CHKB, CD79A, CD36
36	tyrosine32	8.3	PDCD1, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, KIR2DL5A
37	acetylcholine32 9 18 9	11.3	VWF, VIP, BMP6, LEP, LBR, MPO
38	cisplatin32 34 9 9	11.0	VEGFA, BMP6, BGLAP, LEP, LBR, MPO
39	troglitazone32 42 9 9	11.0	VDR, BMP6, LEP, CD36, MMP1, MMP3
40	glutamine32	7.9	VWF, VIP, VDR, BMP6, CHKB, CD36
41	vegf32	7.9	VWF, VIP, BSG, VCAN, BMP2, BMP4
42	thyroxine32 18	8.7	VWF, GC, VIP, VDR, BGLAP, LEP
43	creatinine32	7.4	VWF, GC, SERPINA1, VDR, BMP2, BMP6
44	cyclosporin a32 42	8.4	VWF, VIP, BSG, VDR, BMP2, BMP4
45	vitamin d32	7.3	GC, VDR, BMP2, BMP6, BMP7, BGLAP
46	histamine32 18	8.1	VWF, VIP, BMP6, BGLAP, LBR, S100A8
47	serine32	6.9	RELA, VWF, GC, SERPINA1, VIP, BSG
48	methotrexate32 34 42 9 9	10.5	BMP6, LEP, CHKB, S100A8, CD79A, MMP1
49	indomethacin32 9 9	7.6	VIP, BMP2, BMP6, LEP, MPO, JAK2
50	dexamethasone32 42 34 9 9	8.9	VWF, VIP, VEGFA, VDR, BMP2, BMP4

Cellular components related to spondylitis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.9	TNF, HLA-DRB1, HLA-DRA, HLA-DQA1, HLA-C, HLA-B
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.6	TAPBP, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPB1
3	ER to Golgi transport vesicle membrane	GO:012507	10.5	HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
4	membrane-bounded vesicle	GO:031988	10.5	SPP1, IBSP, BGLAP, BMP4, BMP2
5	membrane raft	GO:045121	10.5	TLR4, LRRK2, TNFRSF1B, TNFRSF1A, TNF, ITLN1
6	MHC class II protein complex	GO:042613	10.3	HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1
7	external side of plasma membrane	GO:009897	10.2	ICOSLG, HLA-DRB1, TNF, TNFRSF11A, CTLA4, TLR2
8	cell surface	GO:009986	10.1	HSPA2, HSPA5, HSPA8, HSPD1, TNF, TNFRSF1A
9	plasma membrane	GO:005886	9.8	HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA
10	proteinaceous extracellular matrix	GO:005578	9.6	ASPN, FBN1, TNFRSF11B, ACAN, TGFB1, HAPLN1
11	extracellular matrix	GO:031012	9.5	PRTN3, SOD1, SOST, HAPLN1, ACAN, COL6A1
12	platelet alpha granule lumen	GO:031093	9.0	TGFB1, TIMP1, ALB, IGF1, VEGFA, SERPINA1
13	extracellular region	GO:005576	7.8	ITLN1, MMP1, MMP3, INS, FCAR, IL1A
14	extracellular space	GO:005615	6.5	CSF3, ADM, ADIPOQ, GC, IL10, IL12B

Biological processes related to spondylitis according to GeneDecks:

(show top 50)    (show all 89)

id	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	11.2	PSMB9, PSMB8, ERAP1, HLA-B, PSMD7, HLA-A
2	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	11.1	PSMB8, PSMD7, CD36, HLA-A, HLA-B, RPS27A
3	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	11.0	CD36, TAPBP, HLA-A, HLA-B, HLA-C, PSMB8
4	regulation of immune response	GO:050776	11.0	KIR2DL3, KIR2DL1, KIR3DL2, KIR2DL4, KIR3DL1, ICAM1
5	positive regulation of interleukin-10 production	GO:032733	11.0	TLR4, IL12B, IL23A, CD40LG, IL4, HSPD1
6	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:019885	10.9	TAP2, TAPBP, ERAP1, ERAP2, TAP1
7	positive regulation of osteoclast differentiation	GO:045672	10.9	CSF1, TNFSF11, TNF, IFNG, IL23R, IL23A
8	positive regulation of interferon-gamma production	GO:032729	10.8	IL12B, TLR4, LTA, TNF, HSPD1, IL23R
9	positive regulation of interleukin-12 production	GO:032735	10.8	IL12B, TLR4, TLR2, CD36, CD40LG, IL23A
10	response to mechanical stimulus	GO:009612	10.7	TNF, SOST, BMP2, BMP4, PTGER4, BGLAP
11	T cell costimulation	GO:031295	10.7	HLA-DRA, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, CTLA4
12	positive regulation of interleukin-6 production	GO:032755	10.7	TNF, IL1B, IL1A, HSPD1, CD36, NOD2
13	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.6	TNFRSF1A, TNFRSF11A, RELA, IL1B, TRADD, TNF
14	positive regulation of tumor necrosis factor production	GO:032760	10.6	TLR4, TLR2, NOD2, IFNG, CD14, TNFRSF1A
15	acute-phase response	GO:006953	10.5	IL6, IL22, IL1RN, SERPINA1, INS, SAA1
16	humoral immune response	GO:006959	10.5	IFNG, CCL2, IL6, CCR6, PDCD1, TREM1
17	monocyte chemotaxis	GO:002548	10.5	TNFSF11, IL6, CCL7, CCL2, CALCA, TNFRSF11A
18	positive regulation of activated T cell proliferation	GO:042104	10.5	ICOSLG, IL12B, IL2, IL23A, IL23R, IL4
19	positive regulation of interleukin-17 production	GO:032740	10.4	NOD2, TGFB1, IL23R, IL23A, IL12B, IL2
20	negative regulation of growth of symbiont in host	GO:044130	10.4	IL10, TNF, IFNG, IL12B, CD36, LTA
21	positive regulation of cytokine secretion	GO:050715	10.4	IL10, TNFSF15, PTGER4, TLR2, TNF, IL1A
22	positive regulation of inflammatory response	GO:050729	10.4	IL23A, TLR4, IL2, IL12B, JAK2, PTGER4
23	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.3	IL2, IL23R, IL23A, IGF1, JAK2, IL12B
24	interferon-gamma-mediated signaling pathway	GO:060333	10.3	IFNG, JAK2, ICAM1, HLA-A, HLA-B, HLA-C
25	positive regulation of NF-kappaB import into nucleus	GO:042346	10.3	IL12B, TNF, TLR2, TLR4, IL23A, IL1B
26	response to glucocorticoid stimulus	GO:051384	10.2	CCL2, TNF, PTGS2, IL1B, ADIPOQ, ALPL
27	skeletal system development	GO:001501	10.2	ALPL, TNFRSF11B, BMP6, BMP7, IGF1, BGLAP
28	positive regulation of T cell proliferation	GO:042102	10.1	IL12B, IL1B, IL23A, IL23R, IL6, IFNG
29	innate immune response	GO:045087	10.1	MEFV, RELA, IL18RAP, RPS27A, IL1R1, IL1RAPL2
30	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	10.1	IL10, IL1B, IL4, IL6, ESR1, TNF
31	elevation of cytosolic calcium ion concentration	GO:007204	10.1	CCR5, CALCA, ADM, CXCR3, JAK2, IL1B
32	lipopolysaccharide-mediated signaling pathway	GO:031663	10.0	IL1B, CCL2, TNF, TLR4, NFKBIA, TLR2
33	response to lipopolysaccharide	GO:032496	10.0	TNFRSF11A, ALPL, IL23R, IL1A, JAK2, S100A8
34	cell-cell signaling	GO:007267	9.9	IL17A, CCL27, EDN1, ADM, CCL7, IL36G
35	defense response to Gram-negative bacterium	GO:050829	9.9	IL12B, IL23A, IL23R, IL6, NOS2, TLR4
36	cellular response to lipopolysaccharide	GO:071222	9.8	IFNG, CCR5, IL12B, NOS2, TNFRSF1B, CD36
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.7	TNF, CAT, TNFRSF11A, ICAM1, IL6, INS
38	cytokine-mediated signaling pathway	GO:019221	9.7	JAK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF1A, TNFSF11
39	response to ethanol	GO:045471	9.6	ADIPOQ, BGLAP, S100A8, IL4, CCL2, ICAM1
40	response to hypoxia	GO:001666	9.6	ADM, TGFB1, TLR4, ADIPOQ, NOS2, CRP
41	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	IFNG, IL1B, INS, JAK2, ICAM1, TLR4
42	immune response	GO:006955	9.5	IL1RN, KIR2DL3, KIR2DL1, KIR2DS5, PDCD1LG2, KIR3DS1
43	negative regulation of cell proliferation	GO:008285	9.4	SOD2, TGFB1, TGIF1, SRF, VDR, BMP2
44	response to drug	GO:042493	9.4	PTGS2, SOD1, STAT3, TGIF1, TGFB1, EDN1
45	anti-apoptosis	GO:006916	9.3	IL2, RELA, MPO, CD40LG, GSTP1, IL10
46	platelet degranulation	GO:002576	9.2	ALB, SOD1, VWF, SERPINA1, VEGFA, APOA1
47	platelet activation	GO:030168	9.2	SOD1, TGFB1, CD40LG, IGF1, SAA1, ALB
48	negative regulation of apoptotic process	GO:043066	9.0	RELA, CAT, VEGFA, BMP4, SOD2, TIMP1
49	inflammatory response	GO:006954	8.9	CSF1, TGFB1, TLR2, NFKB1, SPP1, PTGS2
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	IL23A, BMP6, TLR2, PTH, SRF, IL4

Molecular functions related to spondylitis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-1 receptor antagonist activity	GO:005152	10.9	IL37, IL36RN, IL36G, IL1RN, IL1F10
2	tumor necrosis factor receptor binding	GO:005164	10.8	LTA, TNFSF15, TNFSF11, TNFSF10, TNF, ERAP1
3	interleukin-1 receptor binding	GO:005149	10.7	IL37, IL36B, IL36A, IL1RN, IL1B, IL1A
4	transmembrane signaling receptor activity	GO:004888	10.6	ICAM1, TNFRSF11A, TLR2, TLR4, IL1R1, IL18RAP
5	receptor activity	GO:004872	10.4	TLR2, TNFRSF11B, TNFRSF11A, TREM1, ICAM1, CCR6
6	MHC class II receptor activity	GO:032395	10.3	KRT17, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
7	protease binding	GO:002020	10.1	TNFRSF1A, TNF, HSPA1B, IL1R1, INS, SERPINA1
8	receptor binding	GO:005102	9.9	HLA-B, TNFSF10, TNFSF15, NOS2, LTA, ADM
9	hormone activity	GO:005179	9.4	ADIPOQ, ADM, PRL, EDN1, PTH, CALCA
10	cytokine activity	GO:005125	9.1	ADIPOQ, IL36RN, IL37, IL4, IL6, IFNG
11	protein homodimerization activity	GO:042803	8.8	CRP, NOS2, NFKB1, LRRK2, TGFB1, TAP1
12	growth factor activity	GO:008083	8.3	IL2, IL4, IL6, IGF1, TGFB1, CSF1
13	protein binding	GO:005515	6.8	PTGER4, PTPN2, SRF, CTLA4, NR3C1, CRP