Aliases & Classifications for Spondylitis

MalaCards integrated aliases for Spondylitis:

Name: Spondylitis 12 72 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6590
ICD10 32 M46
ICD9CM 34 720.8 720.89
SNOMED-CT 64 202651004 202653001

Summaries for Spondylitis

MalaCards based summary : Spondylitis is related to spondyloarthropathy 1 and anterior uveitis, and has symptoms including sciatica An important gene associated with Spondylitis is MICA (MHC Class I Polypeptide-Related Sequence A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Methotrexate and Rifampin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

Related Diseases for Spondylitis

Diseases related to Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 32.2 CD40LG CRP HLA-B IL17A NOD2 TNF
2 anterior uveitis 31.0 HLA-B IL6 TNF
3 uveitis 30.5 HLA-B IL17A NOD2 TNF
4 spondylarthropathy 30.3 LTA TNF
5 arthropathy 30.1 CRP MICA TNF
6 spondyloarthropathy 30.0 HLA-B HLA-C IL17A IL6 TNF
7 reactive arthritis 30.0 CRP HLA-B IL17A IL6 TNF
8 iritis 30.0 CD40LG HLA-B TNFRSF1B
9 familial mediterranean fever 29.9 CRP NOD2 TNF
10 arteries, anomalies of 29.9 CRP IL6 TNF
11 psoriatic arthritis 29.9 CRP HLA-B HLA-C IL17A IL23R LTA
12 endocarditis 29.9 CRP IL6 TNF
13 transverse myelitis 29.8 IL17A IL6 TNF
14 myelitis 29.8 IL17A IL6 TNF
15 complex regional pain syndrome 29.8 HLA-B IL6 TNF
16 synovitis 29.8 CRP IL6 TNF
17 brucellosis 29.8 CD40LG CRP IL6 TNF
18 pneumonia 29.8 CD40LG CRP IL6 TNF
19 mixed connective tissue disease 29.8 CD40LG IL6 TNF
20 ischemic heart disease 29.7 CRP IL6 TNF
21 adult-onset still's disease 29.7 CRP IL6 TNF
22 pyelonephritis 29.7 CRP IL6 TNF
23 arthritis 29.6 IL17A IL6 LTA MICA NOD2 TNF
24 connective tissue disease 29.6 CD40LG IL6 MICA TNF
25 temporal arteritis 29.5 CD40LG CRP IL6
26 periodontitis 29.5 CRP IL17A IL6 TNF
27 purpura 29.5 CD40LG CRP TNF
28 hidradenitis suppurativa 29.4 IL17A NOD2 TNF
29 hidradenitis 29.4 IL17A NOD2 TNF
30 meningitis 29.4 CD40LG CRP IL6 TNF
31 vasculitis 29.4 CD40LG CRP TNF TNFRSF1B
32 granulomatous dermatitis 29.3 NOD2 TNF TNFRSF1B
33 osteoarthritis 29.3 CHI3L1 CRP IL6 TNF
34 ulcerative colitis 29.3 CRP IL23R IL6 NOD2 TNF
35 colitis 29.2 IL17A IL23R IL6 NOD2 TNF
36 rheumatic disease 29.2 CD40LG CRP HLA-B TNF
37 bronchiolitis 29.2 CD40LG IL6 TNF
38 cellulitis 29.2 CHI3L1 CRP TNF
39 acquired immunodeficiency syndrome 29.2 CD40LG HLA-B IL6 TNF
40 crohn's disease 29.2 CRP IL23R IL6 NOD2 TNF TNFRSF1B
41 chlamydia 29.1 CD40LG CRP IL6 TNF
42 demyelinating disease 28.9 CD40LG IL17A TNF
43 psoriasis 28.6 HLA-C IL17A IL23R IL6 LTA MICA
44 rheumatoid arthritis 28.3 CD40LG CHI3L1 CRP HLA-B IL17A IL6
45 systemic lupus erythematosus 28.2 CD40LG CRP IL17A IL6 LTA TNF
46 autoimmune disease 28.1 CD40LG HLA-B IL17A IL6 TNF TNFRSF1B
47 bone inflammation disease 28.1 CD40LG CRP IL17A IL6 TNF TNFRSF1B
48 inflammatory bowel disease 27.2 CHI3L1 CRP HLA-B IL17A IL23R IL6
49 gonococcal spondylitis 12.0
50 inflammatory spondylopathy 11.6

Comorbidity relations with Spondylitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to Spondylitis

Symptoms & Phenotypes for Spondylitis

UMLS symptoms related to Spondylitis:


sciatica

GenomeRNAi Phenotypes related to Spondylitis according to GeneCards Suite gene sharing:

25 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.22 HLA-C HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.22 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.22 HLA-C HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.22 HLA-C HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.22 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.22 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.22 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.22 HLA-C HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.22 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.22 NOD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.22 NOD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.22 HLA-C HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.22 HLA-C NOD2 HLA-B MICA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.22 NOD2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.22 HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.22 NOD2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.22 HLA-C HLA-B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.22 NOD2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.22 NOD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.22 MICA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.22 HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.22 MICA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.22 HLA-C HLA-B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.22 HLA-C HLA-B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.22 MICA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.22 HLA-C
27 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 NOD2 SNAPC4 IL17A CD40LG LTA TNF
28 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 NOD2 SNAPC4 IL17A CD40LG LTA TNF

MGI Mouse Phenotypes related to Spondylitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 IL23R IL6 LTA NOD2 TAP1 TAP2
2 immune system MP:0005387 9.8 IL6 LTA NOD2 TAP1 TAP2 ANTXR2
3 skeleton MP:0005390 9.28 IL6 LTA NOD2 SNAPC4 SOST TNF

Drugs & Therapeutics for Spondylitis

Drugs for Spondylitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 264)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
2
Rifampin Approved Phase 4,Phase 3 13292-46-1 5381226 5458213
3
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
4
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5359476 5353980
5
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
6
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
7
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
8
Pamidronate Approved Phase 4,Phase 1,Phase 2 40391-99-9 4674
9
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 156391 1302
10
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
11
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
12
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 9579578 4594
13
Ethambutol Approved Phase 4 74-55-5 14052 3279
14
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
15
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
16
Acetaminophen Approved Phase 4,Early Phase 1 103-90-2 1983
17
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
18
Hydroxychloroquine Approved Phase 4,Phase 3 118-42-3 3652
19
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
20
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
21
Aceclofenac Approved, Investigational Phase 4 89796-99-6
22
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
23
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
25 beta-endorphin Phase 4
26 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
27 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
28 Adrenocorticotropic Hormone Phase 4
29 Natriuretic Agents Phase 4
30 Natriuretic Peptide, Brain Phase 4
31 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
32 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Phase 1
33 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
34 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Vaccines Phase 4,Phase 2
36 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3
37 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
38 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
39 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
41 Hormones Phase 4,Phase 2,Phase 3,Phase 1
42 Antacids Phase 4,Phase 3,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
45 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
46 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
47 Hypolipidemic Agents Phase 4
48 Anti-Infective Agents Phase 4,Phase 2,Phase 3
49 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
50 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 601)

# Name Status NCT ID Phase Drugs
1 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
2 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
3 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
4 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
5 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
6 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
7 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
8 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
9 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
10 The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Unknown status NCT02477852 Phase 4 Isoniazid;Rifampicin;Ethambutol;Pyrazinamide
11 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
12 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
13 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
14 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
15 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
16 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
17 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
18 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4 Enbrel
19 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
20 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
21 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
22 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
23 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
24 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4 Etanercept
25 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4 Etanercept
26 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
27 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
28 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
29 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
30 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
31 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4 alendronate
32 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
33 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
34 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
35 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4 Infliximab; observational study;Methotrexate; observational study
36 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
37 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
38 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
39 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
40 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
41 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
42 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
43 Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis Completed NCT01029847 Phase 4 Adalimumab;Placebo
44 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
45 Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 4
46 A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis Completed NCT01298531 Phase 4 etanercept;etanercept;placebo
47 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
48 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
49 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
50 A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics Completed NCT02470481 Phase 4

Search NIH Clinical Center for Spondylitis

Genetic Tests for Spondylitis

Anatomical Context for Spondylitis

MalaCards organs/tissues related to Spondylitis:

38
Bone, Testes, T Cells, Endothelial, Heart, Skin, B Cells

Publications for Spondylitis

Articles related to Spondylitis:

(show top 50) (show all 1674)
# Title Authors Year
1
Bone formation in ankylosing spondylitis during anti-tumour necrosis factor therapy imaged by 18F-fluoride positron emission tomography. ( 29415219 )
2018
2
The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis: A systematic review. ( 29438717 )
2018
3
MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis. ( 29435070 )
2018
4
Screening for key genes and transcription factors in ankylosing spondylitis by RNA-Seq. ( 29434723 )
2018
5
Stability of fatigue, pain, patient global assessment and the Bath Ankylosing Spondylitis Functional Index (BASFI) in spondyloarthropathy patients with stable disease according to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). ( 29299630 )
2018
6
Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis. ( 29439591 )
2018
7
Response to Tumor Necrosis Factor Inhibition in Male and Female Patients with Ankylosing Spondylitis: Data from a Swiss Cohort. ( 29449504 )
2018
8
Ankylosing Spondylitis Treatment after First Anti-TNF Drug Failure. ( 29431309 )
2018
9
Tuberculous Aortitis Associated With Pleuritis and Spondylitis. ( 29398471 )
2018
10
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
11
Using Self-Reported Patient Experiences to Understand Patient Burden: Learnings from Digital Patient Communities in Ankylosing Spondylitis. ( 29450863 )
2018
12
Safety and Efficacy of Golimumab Administered Intravenously in Adults with Ankylosing Spondylitis: Results through Week 28 of the GO-ALIVE Study. ( 29419454 )
2018
13
The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates. ( 29409751 )
2018
14
Comorbidity, disability, and healthcare expenditure of ankylosing spondylitis in Korea: A population-based study. ( 29420599 )
2018
15
Immune cells involved in the pathogenesis of ankylosing spondylitis. ( 29428668 )
2018
16
Diffusion-weighted Imaging Is a Sensitive and Specific Magnetic Resonance Sequence in the Diagnosis of Ankylosing Spondylitis. ( 29449501 )
2018
17
TNF-I+ level affects etanercept clearance: TNF-I+ concentration as a new correction factor of allometric scaling to predict individual etanercept clearances in patients with ankylosing spondylitis. ( 29436715 )
2018
18
Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis : AIP associate with cIMT in AS. ( 29435680 )
2018
19
Characterization of Patients With Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis in the US-Based Corrona Registry. ( 29409123 )
2018
20
Increased Levels of Oxidative Stress Markers, Soluble CD40 Ligand, and Carotid Intima-Media Thickness Reflect Acceleration of Atherosclerosis in Male Patients with Ankylosing Spondylitis in Active Phase and without the Classical Cardiovascular Risk Factors. ( 28883908 )
2017
21
Assessment of semaphorin 3A and its role in bone remodelling in a group of ankylosing spondylitis patients. ( 27782869 )
2017
22
A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis. ( 28148281 )
2017
23
Endothelial dysfunction is independent of inflammation and altered CCR7 T cell expression in patients with ankylosing spondylitis. ( 28421995 )
2017
24
ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations. ( 28049827 )
2017
25
Epidural Haematoma Causing Paraplegia in a Patient with Ankylosing Spondylitis: A Case Report. ( 28824860 )
2017
26
Prevalence of Ankylosing Spondylitis Disease Activity Score (ASDAS) inactive disease in a cohort of patients treated with TNF-alpha inhibitors. ( 28880727 )
2017
27
Down-Regulation of lncRNA-AK001085 and its Influences on the Diagnosis of Ankylosing Spondylitis. ( 28042142 )
2017
28
Secular trends in sickness absence among Swedish patients with ankylosing spondylitis and psoriatic arthritis. ( 28879599 )
2017
29
Transpseudarthrosis Osteotomy with Interbody Fusion for Kyphotic Spinal Pseudarthrosis in Ankylosing Spondylitis by a Single Posterior Approach: A Retrospective Study and a Brief Relevant Literature Review. ( 28875150 )
2017
30
Assessment of Correlation between Intravoxel Incoherent Motion Diffusion Weighted MR Imaging and Dynamic Contrast-Enhanced MR Imaging of Sacroiliitis with Ankylosing Spondylitis. ( 29445743 )
2017
31
The reliability and validity of a Venezuelan version of the Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). ( 28943073 )
2017
32
Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway. ( 28941122 )
2017
33
Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis. ( 28743287 )
2017
34
MEFV M694V mutation has a role in susceptibility to ankylosing spondylitis: A meta-analysis. ( 28800602 )
2017
35
Comparison of Outcomes of Total Hip Arthroplasty between Patients with Ankylosing Spondylitis and Avascular Necrosis of the Femoral Head. ( 28861192 )
2017
36
Relationship between the gut and the spine: a pilot study of first-degree relatives of patients with ankylosing spondylitis. ( 28879050 )
2017
37
Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis. ( 28901420 )
2017
38
Association between use of disease-modifying antirheumatic drugs and diabetes in patients with ankylosing spondylitis, rheumatoid arthritis, or psoriasis/psoriatic arthritis: a nationwide, population-based cohort study of 84,989 patients. ( 28496328 )
2017
39
Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression. ( 27515058 )
2017
40
Increased expression of TIPE2 mRNA in PBMCs of patients with ankylosing spondylitis is negatively associated with the disease severity. ( 27816498 )
2017
41
Secukinumab provides sustained improvements in the signs and symptoms of active ankylosing spondylitis with high retention rate: 3-year results from the phase III trial, MEASURE 2. ( 29435364 )
2017
42
Evaluation of auditory and cochlear functions in ankylosing spondylitis patients according to the site of involvement. ( 28889257 )
2017
43
Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial. ( 28079501 )
2017
44
Mannose-binding lectin (MBL) deficiency and tuberculosis infection in patients with ankylosing spondylitis. ( 28879439 )
2017
45
A novel role for bone-derived cells in ankylosing spondylitis: Focus on IL-23. ( 28728847 )
2017
46
Ochronosis: a close mimic of ankylosing spondylitis. ( 29088416 )
2017
47
Evaluation of the internal oblique, external oblique, and transversus abdominalis muscles in patients with ankylosing spondylitis: an ultrasonographic study. ( 28891005 )
2017
48
Phlegmonous gastritis in an ankylosing spondylitis patient treated with infliximab. ( 28814069 )
2017
49
Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study. ( 28521824 )
2017
50
The potent suppressive effect of I^-d-mannuronic acid (M2000) on molecular expression of the TLR/NF-kB Signaling Pathway in ankylosing spondylitis patients. ( 28938189 )
2017

Variations for Spondylitis

Expression for Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for Spondylitis

Pathways related to Spondylitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CD40LG CHI3L1 CRP ERAP1 ERAP2 HLA-B
2
Show member pathways
13.41 CD40LG ERAP1 ERAP2 HLA-B HLA-C MICA
3
Show member pathways
13.26 CD40LG IL17A IL23R IL6 LTA TNF
4
Show member pathways
13.18 CD40LG HLA-B HLA-C IL17A IL23R IL6
5
Show member pathways
12.69 HLA-B HLA-C IL6 LTA TAP1 TAP2
6
Show member pathways
12.65 CD40LG IL6 LTA TNF TNFRSF1B
7
Show member pathways
12.54 IL17A IL23R IL6 NOD2 TNF
8
Show member pathways
12.51 HLA-B HLA-C IL6 MICA TNF
9 12.47 CD40LG IL17A TAP1 TAP2 TNF TNFRSF1B
10
Show member pathways
12.4 CD40LG HLA-B HLA-C IL17A IL6 LTA
11
Show member pathways
12.37 CD40LG IL17A IL6 TNF
12 12.36 HLA-B HLA-C IL6 LTA TNF
13 12.08 HLA-B HLA-C TAP1 TAP2
14 12.02 CD40LG HLA-B HLA-C MICA
15
Show member pathways
11.94 HLA-B HLA-C IL17A IL6 LTA TNF
16 11.89 IL17A IL23R IL6 TNF TNFRSF1B
17 11.84 IL6 LTA NOD2 TNF TNFRSF1B
18
Show member pathways
11.81 IL17A IL23R IL6
19
Show member pathways
11.8 IL17A IL23R IL6
20 11.79 IL17A IL6 TNF
21
Show member pathways
11.76 CD40LG LTA TNF TNFRSF1B
22 11.74 IL17A IL23R LTA TNF
23
Show member pathways
11.74 IL17A IL23R IL6 LTA TNF
24
Show member pathways
11.69 CD40LG TNF TNFRSF1B
25
Show member pathways
11.62 CD40LG IL6 TNF
26 11.62 CD40LG IL6 LTA TNF
27 11.54 LTA TNF TNFRSF1B
28
Show member pathways
11.5 LTA TNF TNFRSF1B
29 11.48 IL6 TNF TNFRSF1B
30 11.48 CD40LG IL6 TNF
31 11.32 CD40LG TAP1 TAP2
32 11.25 IL17A IL6 TNF
33 11.14 CD40LG IL17A IL6 LTA TNF
34 10.98 CRP IL6 TNF
35 10.5 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2

GO Terms for Spondylitis

Cellular components related to Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.97 ANTXR2 CHI3L1 ERAP1 ERAP2 HLA-B HLA-C
2 extracellular space GO:0005615 9.85 CD40LG CHI3L1 CRP ERAP1 IL17A IL6
3 external side of plasma membrane GO:0009897 9.73 ANTXR2 CD40LG IL17A TNF
4 MHC class I protein complex GO:0042612 9.4 HLA-B HLA-C
5 TAP complex GO:0042825 9.32 TAP1 TAP2
6 phagocytic vesicle membrane GO:0030670 9.26 HLA-B HLA-C TAP1 TAP2
7 cell surface GO:0009986 9.17 ANTXR2 CD40LG HLA-B HLA-C MICA NOD2
8 extracellular region GO:0005576 10 ANTXR2 CD40LG CHI3L1 CRP ERAP1 IL17A

Biological processes related to Spondylitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.92 ERAP1 ERAP2 HLA-B HLA-C IL23R NOD2
2 adaptive immune response GO:0002250 9.91 ERAP1 ERAP2 TAP1 TAP2
3 regulation of immune response GO:0050776 9.9 CD40LG HLA-B HLA-C MICA
4 immune response GO:0006955 9.86 CD40LG HLA-B HLA-C IL17A IL6 LTA
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 CD40LG IL6 NOD2 TNF
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.81 CD40LG LTA TNF TNFRSF1B
7 positive regulation of T cell proliferation GO:0042102 9.77 CD40LG IL23R IL6
8 humoral immune response GO:0006959 9.76 IL6 LTA TNF
9 defense response to Gram-positive bacterium GO:0050830 9.76 CRP IL6 LTA TNF
10 inflammatory response GO:0006954 9.76 CD40LG CHI3L1 CRP IL17A IL23R IL6
11 positive regulation of interleukin-6 production GO:0032755 9.74 IL6 NOD2 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.72 IL23R LTA TNF
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 HLA-B HLA-C TAP1 TAP2
14 positive regulation of interleukin-17 production GO:0032740 9.63 IL23R NOD2
15 peptide transport GO:0015833 9.63 TAP1 TAP2
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.61 HLA-B HLA-C
17 positive regulation of osteoclast differentiation GO:0045672 9.61 IL17A IL23R TNF
18 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.58 TAP1 TAP2
19 regulation of immunoglobulin secretion GO:0051023 9.56 CD40LG TNF
20 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
21 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.52 LTA TNF
22 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.49 LTA TNF
23 cytosol to ER transport GO:0046967 9.48 TAP1 TAP2
24 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.26 ERAP1 ERAP2 TAP1 TAP2
25 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.1 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2
26 regulation of receptor activity GO:0010469 10.02 CD40LG IL17A IL6 LTA TNF
27 viral process GO:0016032 10.02 HLA-B HLA-C MICA TAP1 TAP2

Molecular functions related to Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC protein binding GO:0042287 9.46 TAP1 TAP2
2 interleukin-6 receptor binding GO:0005138 9.43 ERAP1 IL6
3 peptide-transporting ATPase activity GO:0015440 9.4 TAP1 TAP2
4 TAP1 binding GO:0046978 9.37 TAP1 TAP2
5 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG LTA TNF
6 peptide transporter activity GO:0015197 9.32 TAP1 TAP2
7 MHC class Ib protein binding GO:0023029 9.26 TAP1 TAP2
8 peptide antigen binding GO:0042605 9.13 HLA-B HLA-C TAP1
9 cytokine activity GO:0005125 9.02 CD40LG IL17A IL6 LTA TNF

Sources for Spondylitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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