Summaries for Spondylitis

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Wikipedia:63 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

MalaCards based summary: Spondylitis is related to reactive arthritis and epidural abscess. An important gene associated with Spondylitis is TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Type II interferon signaling (IFNG) and Primary immunodeficiency. The compounds lactulose and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and testes, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Spondylitis

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Spondylitis, Aliases & Descriptions:

Name: Spondylitis 9 43 60


External Ids:

Disease Ontology9 DOID:6590
ICD9CM27 720.89, 720.8

Related Diseases for Spondylitis

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Diseases related to Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 289)
idRelated DiseaseScoreTop Affiliating Genes
1reactive arthritis31.0HLA-B, CRP, TAP2, CD79A
2epidural abscess31.0CRP
3psoriatic arthritis31.0TNFRSF1B, TNF, CRP
4systemic lupus erythematosus30.9CRP
5inflammatory bowel disease30.7CD79A, TNFRSF1A
6spondylarthropathy30.6TNF, CRP
7connective tissue disease30.6CD79A, TNF
8meningitis30.6HLA-B, CRP, CD79A
9arthritis30.6TNF, TNFRSF1A, TNFSF11, MMP3, IL17A
10brucellosis30.5CD79A
11amyloidosis30.5CD79A, CRP, TNFRSF1A, HLA-B
12crohn's disease30.5TNFRSF1B, TNF, CRP, NOD2
13ulcerative colitis30.4TNF, CRP, NOD2
14dermatitis herpetiformis30.3MMP3, CD79A
15osteoporosis30.3TNFSF11, PTH
16adult-onset still's disease30.2CRP, TNFRSF1B
17osteomyelitis30.1CRP, TNFSF11
18pneumonia30.1TNFRSF1B, TNF, IL17A, CRP, CD79A
19uveitis30.1HLA-B, TNFRSF1B, TNF, TNFRSF1A, IL17A, NOD2
20dermatitis30.1TNFRSF1B, IL17A, NOD2, CD79A
21abdominal aortic aneurysm29.9TNFRSF1B, TNFRSF1A, MMP3
22atherosclerosis29.9TNF, MMP3, CHI3L1, IL17A, CRP, NOD2
23vasculitis29.9HLA-B, TNFRSF1B, TNF, IL17A, CRP, CD79A
24vascular disease29.8MMP3, TNFRSF1A, TNF
25colitis29.8TNFRSF1B, TNF, CHI3L1, IL17A, NOD2
26demyelinating disease29.8IL17A, TNF
27breast cancer29.8HLA-B, TNFRSF1B, MMP3, TAP1, TAP2
28behcet's disease29.7CRP, TNF, TNFRSF1B, HLA-B
29coronary artery disease29.7CRP, IL17A, MMP3, TNFSF11, TNFRSF1B
30periodontitis29.6TNF, TNFSF11, MMP3, IL17A
31psoriasis29.4HLA-B, TNFRSF1B, TNF, TNFRSF1A, IL17A, TAP1
32tuberculosis29.4TNFRSF1B, TNF, TNFRSF1A, IL17A, CRP, NOD2
33arthropathy29.2NOD2, CRP, CHI3L1, TNFRSF1B, TNF, TNFSF11
34myeloma29.2HLA-B, TNFRSF1B, TNFRSF1A, TNFSF11, CD79A
35leukemia29.2HLA-B, TNF, TNFRSF1A, IL17A, TAP1, TAP2
36rheumatoid arthritis29.1TNFRSF1B, TNF, TNFRSF1A, TNFSF11, MMP3, CHI3L1
37synovitis28.7TNF, TNFRSF1A, TNFSF11, MMP3, IL17A, CRP
38osteoarthritis28.7TNFRSF1B, TNF, TNFRSF1A, TNFSF11, MMP3, CHI3L1
39spondyloarthropathy 128.0PTH, TNFSF11, TNFRSF1A, TNF, TNFRSF1B, HLA-B
40cauda equina syndrome10.7
41anterior uveitis10.6
42toxoplasmosis10.6CD79A
43aphthous stomatitis10.6HLA-B
44celiac disease10.5CD79A
45pelvic inflammatory disease10.5CRP
46hyperostosis10.5
47diffuse idiopathic skeletal hyperostosis10.5
48cervicitis10.5
49bacteriuria10.5CRP
50ankylosis10.5

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to spondylitis

Symptoms for Spondylitis

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Drugs & Therapeutics for Spondylitis

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Drug clinical trials:

Search ClinicalTrials for Spondylitis

Search NIH Clinical Center for Spondylitis

Genetic Tests for Spondylitis

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Anatomical Context for Spondylitis

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MalaCards organs/tissues related to Spondylitis:

31
Bone, T cells, Testes, Endothelial, Heart, Bone marrow, Whole blood, Myeloid, Eye, Spinal cord, Colon, Liver, Thyroid, Skin, Monocytes, Pituitary, Neutrophil, Brain, Lung, Breast, B cells

Animal Models for Spondylitis or affiliated genes

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MGI Mouse Phenotypes related to Spondylitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0TAP1, PSMB9, TNFRSF1A, TNF, TNFRSF1B
2MP:00053906.7TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH, MMP3
3MP:00107686.3HLA-B, TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH
4MP:00053766.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH, MMP3
5MP:00053974.7NOD2, TAP2, TAPBP, TAP1, IL17A, PSMB9
6MP:00053874.5CD79A, HLA-B, NOD2, TAP2, TAPBP, TAP1

Publications for Spondylitis

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Articles related to Spondylitis:

(show top 50)    (show all 1350)
idTitleAuthorsYear
1
Antitumour necrosis factor I+ treatment reduces retinol-binding protein 4 serum levels in non-diabetic ankylosing spondylitis patients. (24323393)
2013
2
Clinical response, drug survival and predictors thereof in 432 ankylosing spondylitis patients after switching tumour necrosis factor I+ inhibitor therapy: results from the Danish nationwide DANBIO registry. (22941767)
2013
3
Trends of ankylosing spondylitis ossification. (23864924)
2013
4
MICA, a gene contributing strong susceptibility to ankylosing spondylitis. (23727634)
2013
5
Surgical management of contiguous multilevel thoracolumbar tuberculous spondylitis. (22892706)
2013
6
Association between ED in ankylosing spondylitis: a population-based study. (23552581)
2013
7
Airway management in cervical spine ankylosing spondylitis: Between a rock and a hard place. (24403620)
2013
8
Usage of Conventional PCR Technology for the Detection of HLA-B27 Allele: A Significant Molecular Marker of Ankylosing Spondylitis. (24426208)
2013
9
Morphometric Vertebral Assessments via the Use of Dual X-ray Absorptiometry for the Evaluation of Radiographic Damage in Ankylosing Spondylitis: A Pilot Study. (24161790)
2013
10
CT- and fluoroscopy-guided percutaneous screw fixation of a "carrot-stick" spinal fracture in an elderly man with ankylosing spondylitis. (23842576)
2013
11
Cardiorespiratory fitness and cardiovascular risk in patients with ankylosing spondylitis: a cross-sectional comparative study. (23281265)
2013
12
In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis. (23508523)
2013
13
Old and new HLA associations with ankylosing spondylitis. (22881057)
2012
14
Paediatric rheumatology: RCT of adalimumab supports anti-TNF therapy for juvenile-onset ankylosing spondylitis. (23147904)
2012
15
Conventional DMARD therapy (methotrexate-sulphasalazine) may decrease the requirement of biologics in routine practice of ankylosing spondylitis patients: a real-life experience. (23253235)
2012
16
Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis. (22876137)
2012
17
Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. (20952467)
2011
18
Hypoparathyroidism mimicking ankylosing spondylitis and myopathy: a case report. (21876989)
2011
19
Effects of genetic polymorphisms of programmed cell death 1 and its ligands on the development of ankylosing spondylitis. (21791547)
2011
20
Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response. (20722024)
2010
21
Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. (19804562)
2010
22
Severe atlantoaxial subluxation in early ankylosing spondylitis. (20921854)
2010
23
Genetic aspects of osteopenia/osteoporosis in ankylosing spondylitis]. (19938354)
2009
24
Pro-inflammatory effect of leptin on peripheral blood mononuclear cells of patients with ankylosing spondylitis. (19059800)
2009
25
IL-23R polymorphisms in patients with ankylosing spondylitis in Korea. (19369463)
2009
26
The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept. (19488017)
2009
27
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
28
Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis. (18785308)
2008
29
Male osteoporosis with vertebral fractures? Look for ankylosing spondylitis! A report of 10 cases. (17918785)
2007
30
Occlusive retinal vasculitis in a patient with ankylosing spondylitis. (15999133)
2006
31
Elevated serum levels of soluble receptor activator of nuclear factors-kappaB ligand (sRANKL) and reduced bone mineral density in patients with ankylosing spondylitis (AS). (16567356)
2006
32
Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis. (17105859)
2006
33
Study of undifferentiated spondyloarthropathy among first-degree relatives of ankylosing spondylitis probands. (15741196)
2005
34
Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism. (16386647)
2005
35
Bone turnover markers, anterior pituitary and gonadal hormones, and bone mass evaluation using quantitative computed tomography in ankylosing spondylitis. (15592691)
2005
36
Which patients with ankylosing spondylitis should be treated with tumour necrosis factor inhibiting therapy? A survey among Dutch rheumatologists. (15082483)
2004
37
Cytokine correlates of clinical response patterns to infliximab treatment of ankylosing spondylitis. (14672897)
2004
38
Efficacy of anakinra in active ankylosing spondylitis: a clinical and magnetic resonance imaging study. (15066864)
2004
39
Novel approaches in the treatment of ankylosing spondylitis and other spondyloarthritides. (12831346)
2003
40
Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for disease pathogenesis. (12746911)
2003
41
Anti-tumour necrosis factor alpha therapy for ankylosing spondylitis: international experience. (12381511)
2002
42
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in ankylosing spondylitis. (12468823)
2002
43
Interleukin 6 gene promoter polymorphism is not associated with ankylosing spondylitis. (10852271)
2000
44
Ankylosing spondylitis: time to focus on ankylosis. (10229392)
1999
45
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
46
A genome-wide screen for susceptibility loci in ankylosing spondylitis. (9550467)
1998
47
Osteomalacia and osteoporosis in a woman with ankylosing spondylitis. (9157786)
1996
48
Spinal abnormalities similar to ankylosing spondylitis in a 58-year-old woman with ochronosis. (7641516)
1995
49
IgM, IgA and IgG class serum antibodies against Klebsiella pneumoniae and Escherichia coli lipopolysaccharides in patients with ankylosing spondylitis. (7981989)
1994
50
Rapidly progressive aortic incompetence in juvenile ankylosing spondylitis: a case report. (6233987)
1984

Variations for Spondylitis

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Expression for genes affiliated with Spondylitis

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Search GEO for disease gene expression data for Spondylitis.

Pathways for genes affiliated with Spondylitis

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Pathways related to Spondylitis according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HLA-B, PSMB9, TAP1
29.8TAP1, TAP2, CD79A
39.6PTH, TNFSF11
49.5HLA-B, FCAR, TAP1, TAP2
5
Show member pathways
9.4TAP2, TAPBP, TAP1, HLA-B
69.3CD79A, TAP2, TAP1, TNFSF11
7
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.2CD79A, IL17A, TNF
8
Show member pathways
9.0TNFRSF1A, TNF
99.0PTH, TNFSF11, TNF
10
Show member pathways
8.8CD79A, TAP2, TAPBP, TAP1, PSMB9, HLA-B
118.8TNF, TNFRSF1A, NOD2
128.8TNF, TNFRSF1A, NOD2
138.6TNF, TNFSF11, MMP3, IL17A
148.6TNFSF11, TNFRSF1A, TNFRSF1B
158.5TNFRSF1B, TNF, TNFRSF1A
16
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
8.5TNFRSF1A, TNF, TNFRSF1B
17
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
8.5TNFRSF1A, TNF, TNFRSF1B
18
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.5TNFRSF1B, TNF, TNFRSF1A
19
Show member pathways
Alternative NF-kappaB pathway36
8.5TNFRSF1A, TNF, TNFRSF1B
20
Show member pathways
8.5TNFRSF1B, TNF, TNFRSF1A
21
Show member pathways
8.5TNFRSF1B, TNF, TNFRSF1A
228.5TNFRSF1A, TNF, TNFRSF1B
23
Show member pathways
8.5TNFRSF1B, TNF, TNFRSF1A
24
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.5TNFRSF1A, TNF, TNFRSF1B
258.5TNFRSF1A, TNF, TNFRSF1B
268.5TNFSF11, TNFRSF1A, TNF
27
Show member pathways
8.5TNF, TNFRSF1A, TNFSF11
288.5TNFSF11, TNFRSF1A, TNF
29
Show member pathways
8.4TNF, TNFRSF1A, IL17A, NOD2
30
Show member pathways
8.4TAP2, TAP1, TNFRSF1A, TNF, HLA-B
31
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11
32
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
8.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11
33
Show member pathways
8.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11
348.0TNFSF11, TNFRSF1A, TNF, TNFRSF1B
357.9TNFRSF1B, TNF, TNFRSF1A, MMP3, NOD2
36
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
7.7HLA-B, TNF, TNFRSF1A, PSMB9, TAP1, TAPBP
37
Show member pathways
7.6TNFRSF1B, TNF, TNFRSF1A, TNFSF11, IL17A
38
Show member pathways
7.4TAP2, HLA-B, TNFRSF1B, TNF, TNFRSF1A, TAP1

Compounds for genes affiliated with Spondylitis

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Compounds related to Spondylitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1lactulose4310.0CRP, NOD2, CD79A
2pamidronate43 49 1211.5CRP, TNFSF11, PTH
3deoxypyridinoline439.4CRP, MMP3, PTH, TNFSF11
4sulfasalazine28 43 49 1212.3CRP, MMP3, TNF, CD79A
5prednisolone43 28 1211.1MMP3, NOD2, CRP, CD79A, TNF
6pmma439.1CRP, CD79A, TNFSF11
7blys439.1TNF, TNFRSF1A, CD79A
8okt3438.8TNF, TNFRSF1A, CRP, CD79A
9polyethylene glycol438.8TNFRSF1B, TNFRSF1A, CRP, CD79A
10tacrolimus43 49 1210.6HLA-B, TNF, TNFSF11, NOD2, CD79A, IL17A
11prostaglandin438.6MMP3, IL17A, PTH, TNF, TNFSF11
12p003438.6CHI3L1, TNFRSF1A, HLA-B, CRP
13vitamin d438.6CD79A, PTH, MMP3, TNFSF11, TNFRSF1B
14fibrinogen438.6CD79A, CRP, HLA-B, TNF, TNFRSF1B
15adalimumab43 49 1210.6TNFRSF1A, TNF, MMP3, CRP, CD79A
16leflunomide43 49 1210.6TNF, TNFRSF1A, TNFSF11, MMP3
17chloroquine43 2 49 28 1212.5TNFRSF1A, CD79A, TNF, TNFRSF1B
18p002438.5TNFRSF1A, MMP3, TNFRSF1B, IL17A, CRP
19ns 39843 599.5TNF, TNFSF11, TNFRSF1A, IL17A
20ivig438.4TNF, CD79A, CRP, TNFRSF1B, TNFRSF1A
21neopterin438.3CD79A, CRP, TNFRSF1A, TNF, TNFRSF1B
22alanine438.2TAP1, TAP2, CD79A, TAPBP, TNFRSF1A, MMP3
23curcumin438.2IL17A, TNFRSF1A, MMP3, TNF, TNFRSF1B
24sp 60012543 599.1TNFSF11, TNF, TNFRSF1A, IL17A
25atp43 289.1TNFSF11, PTH, TAP2, TAP1, MMP3, TNFRSF1A
26n acetylcysteine438.0CRP, CD79A, TNFSF11, TNF, TNFRSF1A, MMP3
27indomethacin43 28 59 1210.9TNF, TNFRSF1A, TNFSF11, MMP3, CD79A, IL17A
28sb 20358043 598.9MMP3, CRP, IL17A, TNFSF11, TNFRSF1A, TNF
29testosterone43 59 24 1210.8TNFSF11, PTH, HLA-B, CRP, CD79A, TNFRSF1B
30endotoxin437.8IL17A, NOD2, TNFRSF1A, TNF, TNFRSF1B, HLA-B
31forskolin43 49 129.8TNFRSF1A, TNFRSF1B, TNFSF11, PTH, MMP3, IL17A
32creatinine437.7CD79A, HLA-B, TNFRSF1A, TNFSF11, PTH, MMP3
33h2o2437.7CD79A, HLA-B, TNFSF11, TNFRSF1B, TNFRSF1A, TNF
34retinoic acid43 248.5TNF, MMP3, CD79A, TAPBP, TNFRSF1A, TNFRSF1B
35rantes437.5IL17A, TNFRSF1A, TNFRSF1B, HLA-B, MMP3, TNF
36etanercept43 49 129.4TNFRSF1A, TNF, TNFSF11, MMP3, IL17A, CRP
37oxygen43 248.3TNFSF11, TNFRSF1B, TNFRSF1A, TNF, NOD2, MMP3
38estrogen437.3CHI3L1, MMP3, TNFSF11, PTH, TNFRSF1A, TNFRSF1B
39cyclosporin a43 28 599.2TNFSF11, IL17A, MMP3, CD79A, TNFRSF1B, TNF
40infliximab43 49 129.2NOD2, TNFRSF1B, TNF, TNFRSF1A, TNFSF11, MMP3
41methotrexate49 43 129.2TNF, TNFRSF1A, TNFRSF1B, TNFSF11, IL17A, CRP
42calcium43 49 24 1210.2HLA-B, TNFRSF1B, PTH, MMP3, NOD2, TAP2
43lipid437.1HLA-B, TNFRSF1B, TNFRSF1A, TNF, TNFSF11, CRP
44serine437.1TNFRSF1B, TNFRSF1A, TNFSF11, FCAR, MMP3, NOD2
45tyrosine437.1MMP3, FCAR, PTH, TNFRSF1A, TNFSF11, TNFRSF1B
46cycloheximide437.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH, MMP3
47pge2436.9MMP3, HLA-B, TNFRSF1B, CD79A, TNF, TNFRSF1A
48dexamethasone43 49 28 129.9TNFRSF1A, TNFSF11, HLA-B, IL17A, PTH, MMP3
49nitric oxide43 24 128.8PTH, TNFRSF1B, IL17A, TNF, CHI3L1, TNFRSF1A
50vegf436.8TNFSF11, PTH, MMP3, IL17A, CRP, CD79A

GO Terms for genes affiliated with Spondylitis

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Cellular components related to Spondylitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:00428259.8TAP2, TAPBP, TAP1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.8TAPBP, HLA-B
3external side of plasma membraneGO:00098978.9CD79A, IL17A, TNF
4cell surfaceGO:00099868.6HLA-B, TNF, TNFRSF1A, NOD2
5membrane raftGO:00451218.4TNFRSF1B, TNF, TNFRSF1A, CD79A
6integral component of plasma membraneGO:00058877.9HLA-B, TNF, TNFRSF1A, TNFSF11, FCAR
7extracellular regionGO:00055767.5TNFRSF1B, TNFRSF1A, TNFSF11, PTH, FCAR, MMP3
8plasma membraneGO:00058867.1HLA-B, TNFRSF1B, TNF, TNFRSF1A, FCAR, TAP1
9extracellular spaceGO:00056156.9TNF, TNFRSF1A, TNFSF11, PTH, MMP3, CHI3L1

Biological processes related to Spondylitis according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:004696710.4TAP2, TAP1
2oligopeptide transmembrane transportGO:003567210.4TAP2, TAP1
3intracellular transport of viral protein in host cellGO:001906010.3TAP1, TAP2
4positive regulation of T cell mediated cytotoxicityGO:000191610.2TAP2, TAP1, HLA-B
5detection of bacteriumGO:001604510.1HLA-B, NOD2
6defense responseGO:000695210.1NOD2, TAP1, HLA-B
7response to lead ionGO:001028810.1CRP, PTH
8antigen processing and presentation of endogenous peptide antigen via MHC class IGO:001988510.0TAP2, TAPBP, TAP1
9peptide transportGO:001583310.0TAP2, TAPBP, TAP1
10positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00029259.9NOD2, TNF
11negative regulation of lipid storageGO:00108889.8TNF, CRP
12negative regulation of growth of symbiont in hostGO:00441309.8TNF, NOD2
13bone resorptionGO:00454539.7PTH, TNFSF11
14defense response to Gram-positive bacteriumGO:00508309.7TNF, CRP, NOD2
15positive regulation of membrane protein ectodomain proteolysisGO:00510449.5TNF, TNFRSF1B
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00024799.5TAP2, TAPBP, TAP1, PSMB9, HLA-B
17antigen processing and presentation of exogenous peptide antigen via MHC class IGO:00425909.5HLA-B, PSMB9, TAP1, TAPBP, TAP2
18antigen processing and presentation of peptide antigen via MHC class IGO:00024749.5HLA-B, PSMB9, TAP1, TAPBP, TAP2
19positive regulation of ERK1 and ERK2 cascadeGO:00703749.4TNF, CHI3L1, NOD2
20positive regulation of JNK cascadeGO:00463309.4TNF, TNFSF11, NOD2
21tumor necrosis factor-mediated signaling pathwayGO:00332099.3TNFSF11, TNF
22positive regulation of osteoclast differentiationGO:00456729.3TNF, TNFSF11, IL17A
23positive regulation of NF-kappaB transcription factor activityGO:00510929.3TNF, TNFSF11, NOD2
24response to ethanolGO:00454719.3CRP, PTH, TNFRSF1A
25positive regulation of protein kinase B signalingGO:00518979.2CHI3L1, TNFSF11, TNF
26osteoclast differentiationGO:00303169.0TNFSF11, TNF
27negative regulation of interleukin-6 productionGO:00327158.9TNFRSF1A, TNF
28intrinsic apoptotic signaling pathway in response to DNA damageGO:00086308.8TNFRSF1A, TNF, TNFRSF1B
29response to hypoxiaGO:00016668.7TNF, TNFRSF1A, CRP
30positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.6TNF, TNFRSF1A, TNFSF11, NOD2
31immune responseGO:00069558.5HLA-B, TNFRSF1B, TNFSF11, FCAR, IL17A, TAPBP
32positive regulation of transcription from RNA polymerase II promoterGO:00459447.9TNF, TNFRSF1A, TNFSF11, PTH, IL17A, NOD2
33inflammatory responseGO:00069547.8TNFRSF1B, TNF, TNFRSF1A, CHI3L1, IL17A, CRP

Molecular functions related to Spondylitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:004698010.2TAP1, TAP2
2MHC class Ib protein bindingGO:002302910.2TAP1, TAP2
3peptide transporter activityGO:001519710.1TAP1, TAP2
4oligopeptide-transporting ATPase activityGO:001542110.0TAP2, TAP1
5peptide antigen-transporting ATPase activityGO:001543310.0TAP2, TAPBP
6TAP2 bindingGO:00469799.8TAP1, TAPBP, TAP2
7TAP1 bindingGO:00469789.8TAP1, TAPBP, TAP2
8MHC class I protein bindingGO:00422889.8TAP1, TAPBP, TAP2
9peptide antigen bindingGO:00426059.6TAP2, TAPBP, TAP1, HLA-B
10tumor necrosis factor receptor bindingGO:00051649.3TNFSF11, TNF
11tumor necrosis factor-activated receptor activityGO:00050319.0TNFRSF1B, TNFRSF1A
12cytokine activityGO:00051258.7IL17A, TNFSF11, TNF

Products for genes affiliated with Spondylitis

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3CDC
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