Aliases & Classifications for Spondylitis

Aliases & Descriptions for Spondylitis:

Name: Spondylitis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6590
ICD10 33 M46
ICD9CM 35 720.8 720.89
SNOMED-CT 64 202651004 202653001
UMLS 69 C0029644

Summaries for Spondylitis

MalaCards based summary : Spondylitis is related to psoriatic arthritis and tuberculosis, and has symptoms including sciatica An important gene associated with Spondylitis is ERAP2 (Endoplasmic Reticulum Aminopeptidase 2), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Methotrexate and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Wikipedia : 71 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

Related Diseases for Spondylitis

Diseases related to Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
id Related Disease Score Top Affiliating Genes
1 psoriatic arthritis 32.1 MICA NOD2 TNF
2 tuberculosis 29.8 CD40LG IL17A TNF
3 lichen amyloidosis 29.5 TAP1 TAP2
4 aseptic meningitis 29.5 HLA-B TAP2 TNF
5 rheumatoid arthritis 29.2 CD40LG CHI3L1 CRP IL17A IL1RN LTA
6 cranial nerve palsy 29.0 CRP MICA TNF
7 collagenous colitis 28.9 CRP IL17A IL23R NOD2 TNF
8 dermatitis herpetiformis 28.9 CD40LG IL17A TNF TNFRSF1B
9 spondyloarthropathy 1 12.1
10 gonococcal spondylitis 11.8
11 spinal disease 11.1
12 inflammatory spondylopathy 10.8
13 kummell's disease 10.8
14 temporomandibular ankylosis 10.8
15 ossification of the posterior longitudinal ligament of spine 10.8
16 arthritis 10.4
17 swine influenza 10.3 CRP HLA-B TNF
18 gonococcal endophthalmia 10.3 HLA-B IL1RN TNF
19 hepatitis 10.3 HLA-B HLA-C TNF
20 benign neonatal seizures 10.2 CRP IL1RN TNF
21 nemaline myopathy 1, autosomal dominant or recessive 10.2 IL1RN TNF TNFRSF1B
22 bickerstaff brainstem encephalitis 10.2 HLA-B HLA-C TAP1 TAP2
23 cauda equina syndrome 10.2
24 uveitis 10.2
25 patau syndrome 10.2 CRP TNF TNFRSF1B
26 idiopathic hypertrophic pachymeningitis 10.2 IL23R LTA TNF
27 keratoconus 10.1 IL17A IL1RN TNF
28 female reproductive system disease 10.1 IL17A NOD2 TNF
29 kernicterus due to isoimmunization 10.1 HLA-C LTA TNF
30 leptospirosis 10.1 IL17A NOD2 TNF
31 orthostatic proteinuria 10.1 IL1RN LTA TNF
32 follicular adenoma 10.1 CRP HLA-B IL17A TNF
33 crohn's colitis 10.1 IL17A NOD2 TNF
34 human immunodeficiency virus infectious disease 10.1 CD40LG CRP TNF
35 chronic erythremia 10.1 CD40LG HLA-B MICA
36 anterior uveitis 10.1
37 dermatomycosis 10.1 CD40LG CRP TNF
38 rift valley fever 10.1 CRP LTA TNF
39 orbital osteomyelitis 10.1 HLA-B HLA-C IL17A TNF
40 dextrocardia 10.1 CD40LG IL1RN TNF
41 plummer's disease 10.1 CD40LG CRP TNF
42 anterior corneal pigmentation 10.1 HLA-B HLA-C IL17A
43 wagr syndrome 10.1 CRP IL23R NOD2 TNF
44 primary ciliary dyskinesia 10.1 LTA TNF TNFRSF1B
45 epstein-barr virus, susceptibility to chronic infection by 10.1 ERAP1 ERAP2 HLA-C IL17A
46 parasitic helminthiasis infectious disease 10.1 CD40LG HLA-B TNF
47 atrophy of prostate 10.1 CD40LG CRP TNF
48 carotenemia 10.1 CD40LG CRP TNF
49 plasmodium falciparum malaria 10.1 CD40LG HLA-B TNFRSF1B
50 esophageal candidiasis 10.1 HLA-B IL17A NOD2 TNF

Comorbidity relations with Spondylitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to Spondylitis

Symptoms & Phenotypes for Spondylitis

UMLS symptoms related to Spondylitis:


sciatica

GenomeRNAi Phenotypes related to Spondylitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.22 HLA-C HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.22 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.22 HLA-C HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.22 HLA-C HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.22 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.22 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.22 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.22 HLA-C HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.22 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.22 NOD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.22 NOD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.22 HLA-C HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.22 HLA-C MICA HLA-B NOD2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.22 NOD2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.22 HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.22 NOD2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.22 HLA-C HLA-B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.22 NOD2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.22 NOD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.22 MICA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.22 HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.22 MICA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.22 HLA-C HLA-B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.22 HLA-C HLA-B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.22 MICA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.22 HLA-C
27 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 TNF TNFRSF1B CD40LG IL17A LTA NOD2
28 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 TNF TNFRSF1B CD40LG IL17A LTA NOD2

MGI Mouse Phenotypes related to Spondylitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 CD40LG CHI3L1 ERAP1 IL17A IL1RN IL23R
2 immune system MP:0005387 9.8 TAP1 TAP2 TNF TNFRSF1B ANTXR2 CD40LG
3 skeleton MP:0005390 9.28 CD40LG IL17A IL1RN LTA NOD2 SNAPC4

Drugs & Therapeutics for Spondylitis

Drugs for Spondylitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 246)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
2
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
3
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
4
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
5
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
6
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
7
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
8
Certolizumab pegol Approved Phase 4,Phase 3,Phase 1 428863-50-7
9
Rifampin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
10
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
13
Pamidronate Approved Phase 4,Phase 1,Phase 2 40391-99-9 4674
14
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
15
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
16
Aceclofenac Approved Phase 4 89796-99-6
17
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
18
Isoniazid Approved Phase 4 54-85-3 3767
19
Pyrazinamide Approved Phase 4 98-96-4 1046
20
Ethambutol Approved Phase 4 74-55-5 3279 14052
21
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
23 beta-endorphin Phase 4
24 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
25 Chelating Agents Phase 4,Phase 3
26 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
27 Natriuretic Agents Phase 4
28 Natriuretic Peptide, Brain Phase 4
29 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Adrenocorticotropic Hormone Phase 4
31 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Phase 1
32 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
33 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
34 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
35 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
36 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Hormone Antagonists Phase 4,Phase 2,Phase 3
38 Hormones Phase 4,Phase 2,Phase 3
39 Vaccines Phase 4,Phase 2
40 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
42 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
43 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
44 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Infective Agents Phase 4,Phase 2,Phase 3
46 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
47 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
49 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
50 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 544)
id Name Status NCT ID Phase
1 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4
2 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4
3 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4
4 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
5 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4
6 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4
7 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
8 Effects of Different Anti-rheumatic Treatments of Arthritis on Antibody Response Following Pneumococcal Vaccination Using Prevenar® Unknown status NCT00828997 Phase 4
9 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4
10 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4
11 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4
12 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4
13 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4
14 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4
15 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4
16 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4
17 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4
18 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4
19 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
20 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4
21 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4
22 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4
23 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4
24 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
25 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4
26 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
27 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
28 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4
29 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4
30 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4
31 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4
32 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4
33 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4
34 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4
35 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4
36 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
37 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4
38 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4
39 Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis Completed NCT01029847 Phase 4
40 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4
41 Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 4
42 A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis Completed NCT01298531 Phase 4
43 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4
44 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4
45 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4
46 A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics Completed NCT02470481 Phase 4
47 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4
48 National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study Completed NCT01123265 Phase 4
49 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4
50 REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®) Completed NCT00127842 Phase 4

Search NIH Clinical Center for Spondylitis

Genetic Tests for Spondylitis

Anatomical Context for Spondylitis

MalaCards organs/tissues related to Spondylitis:

39
Bone, T Cells, Testes, Endothelial, Heart, Myeloid, Spinal Cord

Publications for Spondylitis

Articles related to Spondylitis:

(show top 50) (show all 1594)
id Title Authors Year
1
Association between use of disease-modifying antirheumatic drugs and diabetes in patients with ankylosing spondylitis, rheumatoid arthritis, or psoriasis/psoriatic arthritis: a nationwide, population-based cohort study of 84,989 patients. ( 28496328 )
2017
2
Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial. ( 28079501 )
2017
3
Down-Regulation of lncRNA-AK001085 and its Influences on the Diagnosis of Ankylosing Spondylitis. ( 28042142 )
2017
4
Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome. ( 28063628 )
2017
5
TNFR1 -383 AE8C polymorphism and ankylosing spondylitis in a Russian Caucasian population: a preliminary study. ( 28363009 )
2017
6
Single nucleotide polymorphisms of ABCB1 gene and response to etanercept treatment in patients with ankylosing spondylitis in a Chinese Han population. ( 28151874 )
2017
7
Increased expression of TIPE2 mRNA in PBMCs of patients with ankylosing spondylitis is negatively associated with the disease severity. ( 27816498 )
2017
8
Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers. ( 28042135 )
2017
9
Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study. ( 28521824 )
2017
10
ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations. ( 28049827 )
2017
11
Spontaneous bilateral quadriceps rupture in a patient with ankylosing spondylitis: A case report. ( 28065978 )
2017
12
rs657075 (CSF2) Is Associated with the Disease Phenotype (BAS-G) of Ankylosing Spondylitis. ( 28054948 )
2017
13
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. ( 28069576 )
2017
14
Differential Expression Profiles of Long Noncoding RNA and mRNA of Osteogenically Differentiated Mesenchymal Stem Cells in Ankylosing Spondylitis. ( 27182066 )
2016
15
Utility of DXA scanning and risk factors for osteoporosis in ankylosing spondylitis-A prospective study. ( 27162010 )
2016
16
Clinical and imaging signs of spondyloarthritis in first-degree relatives of HLA-B27 positive ankylosing spondylitis patients: The pre-spondyloarthritis (Pre-SpA) cohort. ( 27214232 )
2016
17
Association between IL-4 gene polymorphisms, IL-4 serum levels, and ankylosing spondylitis. ( 27813599 )
2016
18
IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis. ( 27165176 )
2016
19
Surgical treatment of spondylitis and diaphragm relaxation in patient less than 1 year old. ( 27591064 )
2016
20
Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis. ( 26590821 )
2016
21
Different roles of TNF inhibitors in acute anterior uveitis associated with ankylosing spondylitis: state of the art. ( 27686662 )
2016
22
Arterial stiffness is not increased in patients with short duration rheumatoid arthritis and ankylosing spondylitis. ( 27653044 )
2016
23
Ankylosing spondylitis. ( 27634163 )
2016
24
The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review. ( 26232179 )
2016
25
Association between arterial stiffness, disease activity and functional impairment in ankylosing spondylitis patients: a cross-sectional study. ( 27169859 )
2016
26
Comparative Efficacy and Acceptability of Anti-TNF-Alpha Therapy in Ankylosing Spondylitis: A Mixed-Treatments Comparison. ( 27643888 )
2016
27
Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis. ( 27108589 )
2016
28
Comparison on radiographic progression for 5 years between juvenile onset ankylosing spondylitis and adult onset ankylosing spondylitis: an observational study of the Korean SpondyloArthropathy Registry (OSKAR) data. ( 27051061 )
2016
29
Increased Levels of Serum Ischemia Modified Albumin in Patients with Ankylosing Spondylitis. ( 27215084 )
2016
30
Cervical Spondylitis and Epidural Abscess Caused by Brucellosis: a Case Report and Literature Review. ( 28068278 )
2016
31
Ankylosing Spondylitis: A rheumatology clinic experience. ( 27182241 )
2016
32
Retrograde pyelonephritis and lumbar spondylitis as a result of Salmonella typhi in a typeA 2 diabetes patient with neurogenic bladder. ( 27330732 )
2016
33
Simultaneous occurrence of ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (Forestier-RotA"s-QuAcrol disease). ( 27131856 )
2016
34
Development and Validation of a Short Form of the Social Role Participation Questionnaire in Patients with Ankylosing Spondylitis. ( 27182067 )
2016
35
Discovertebral (Andersson) lesion of the Ankylosing Spondylitis, a cause of autonomic dysreflexia in spinal cord injury. ( 28053752 )
2016
36
Sacroiliitis and Spondylitis with Sternoclavicular Hyperostosis: SAPHO or an Ankylosing Spondylitis Variant? ( 26712445 )
2016
37
Coexistence of Ankylosing Spondylitis and Neurofibromatosis Type 1. ( 27597922 )
2016
38
The influence of ERAP1 gene variants on clinical phenotype in ankylosing spondylitis. ( 27095091 )
2016
39
Association Between Dentin Matrix Protein 1 (rs10019009) Polymorphism and Ankylosing Spondylitis in a Chinese Han Population from Shandong Province. ( 26960368 )
2016
40
Idiopathic Hypoparathyroidism Mimicking Ankylosing Spondylitis: A Case Report. ( 27115113 )
2016
41
Distinct expression of chemokine-like factor 1 in synovium of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. ( 26838743 )
2016
42
Recurrent macrophage activation syndrome since toddler age in an adolescent boy with HLA B27 positive juvenile ankylosing spondylitis. ( 27826329 )
2016
43
Circulating levels of Th1 and Th2 chemokines in patients with ankylosing spondylitis. ( 26827189 )
2016
44
Gene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells in Rheumatic Disorders: Ankylosing Spondylitis and Rheumatoid Arthritis. ( 26996117 )
2016
45
Vertebral body or intervertebral disc wedging: which contributes more to thoracolumbar kyphosis in ankylosing spondylitis patients?: A retrospective study. ( 27661026 )
2016
46
Radiographic progression in patients with ankylosing spondylitis according to tumor necrosis factor blocker exposure: Observation Study of Korean Spondyloarthropathy Registry (OSKAR) data. ( 26948670 )
2016
47
The role of Vitamin D in immuno-inflammatory responses in Ankylosing Spondylitis patients with and without Acute Anterior Uveitis. ( 27713770 )
2016
48
Role of histone deacetylase 3 in ankylosing spondylitis via negative feedback loop with microRNA-130a and enhancement of tumor necrosis factor-1I+ expression in peripheral blood mononuclear cells. ( 26531724 )
2016
49
Optimal chin-brow vertical angle for sagittal visual fields in ankylosing spondylitis kyphosis. ( 27146808 )
2016
50
Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis. ( 27538101 )
2016

Variations for Spondylitis

Expression for Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for Spondylitis

Pathways related to Spondylitis according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 CD40LG CHI3L1 CRP ERAP1 ERAP2 HLA-B
2
Show member pathways
13.37 CD40LG ERAP1 ERAP2 HLA-B HLA-C MICA
3
Show member pathways
13.13 CD40LG HLA-B HLA-C IL17A IL1RN IL23R
4
Show member pathways
12.68 HLA-B HLA-C LTA TAP1 TAP2 TNF
5
Show member pathways
12.55 CD40LG HLA-B HLA-C IL17A LTA MICA
6 12.32 HLA-B HLA-C LTA TNF
7 12.3 CD40LG IL17A IL1RN TAP1 TAP2 TNF
8 12.03 HLA-B HLA-C TAP1 TAP2
9
Show member pathways
11.98 HLA-B HLA-C IL17A LTA TNF
10 11.97 CD40LG HLA-B HLA-C MICA
11 11.85 IL17A IL23R TNF TNFRSF1B
12 11.81 LTA NOD2 TNF TNFRSF1B
13
Show member pathways
11.79 IL17A IL23R LTA TNF
14 11.77 CD40LG LTA TNF
15
Show member pathways
11.66 CD40LG LTA TNF TNFRSF1B
16
Show member pathways
11.64 CD40LG TNF TNFRSF1B
17 11.62 CD40LG LTA TNF
18 11.61 IL17A IL23R LTA TNF
19 11.48 LTA TNF TNFRSF1B
20
Show member pathways
11.44 LTA TNF TNFRSF1B
21 11.42 IL1RN TNF TNFRSF1B
22 11.27 CD40LG TAP1 TAP2
23 11.12 CD40LG IL17A LTA TNF
24 10.5 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2

GO Terms for Spondylitis

Cellular components related to Spondylitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.97 ANTXR2 CHI3L1 ERAP1 ERAP2 HLA-B HLA-C
2 external side of plasma membrane GO:0009897 9.76 ANTXR2 CD40LG IL17A TNF
3 cell surface GO:0009986 9.5 ANTXR2 CD40LG HLA-B HLA-C MICA NOD2
4 phagocytic vesicle membrane GO:0030670 9.46 HLA-B HLA-C TAP1 TAP2
5 MHC class I protein complex GO:0042612 9.43 HLA-B HLA-C
6 host cell GO:0043657 9.4 TAP1 TAP2
7 TAP complex GO:0042825 9.32 TAP1 TAP2
8 extracellular space GO:0005615 9.32 CD40LG CHI3L1 CRP ERAP1 IL17A IL1RN
9 extracellular region GO:0005576 10 ANTXR2 CD40LG CHI3L1 CRP ERAP1 IL17A

Biological processes related to Spondylitis according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CD40LG HLA-B HLA-C IL17A IL1RN LTA
2 regulation of immune response GO:0050776 9.88 CD40LG HLA-B HLA-C MICA
3 adaptive immune response GO:0002250 9.87 ERAP1 ERAP2 TAP1 TAP2
4 immune system process GO:0002376 9.86 ERAP1 ERAP2 HLA-B HLA-C IL23R NOD2
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.78 CD40LG LTA TNF TNFRSF1B
6 defense response to Gram-positive bacterium GO:0050830 9.77 CRP LTA TNF
7 inflammatory response GO:0006954 9.76 CD40LG CHI3L1 CRP IL17A IL1RN IL23R
8 antigen processing and presentation GO:0019882 9.73 HLA-B HLA-C MICA
9 positive regulation of interferon-gamma production GO:0032729 9.69 IL23R LTA TNF
10 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.67 HLA-B HLA-C TAP1 TAP2
11 positive regulation of interleukin-17 production GO:0032740 9.62 IL23R NOD2
12 peptide transport GO:0015833 9.61 TAP1 TAP2
13 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.61 IL17A NOD2
14 negative regulation of lipid storage GO:0010888 9.59 CRP TNF
15 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-B HLA-C
16 positive regulation of osteoclast differentiation GO:0045672 9.58 IL17A IL23R TNF
17 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.55 TAP1 TAP2
18 intracellular transport of viral protein in host cell GO:0019060 9.54 TAP1 TAP2
19 regulation of immunoglobulin secretion GO:0051023 9.52 CD40LG TNF
20 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.49 LTA TNF
21 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.46 LTA TNF
22 cytosol to ER transport GO:0046967 9.43 TAP1 TAP2
23 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.26 ERAP1 ERAP2 TAP1 TAP2
24 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.1 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2

Molecular functions related to Spondylitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC protein binding GO:0042287 9.46 TAP1 TAP2
2 peptide-transporting ATPase activity GO:0015440 9.43 TAP1 TAP2
3 tumor necrosis factor receptor binding GO:0005164 9.43 CD40LG LTA TNF
4 TAP1 binding GO:0046978 9.4 TAP1 TAP2
5 peptide transporter activity GO:0015197 9.37 TAP1 TAP2
6 peptide antigen binding GO:0042605 9.33 HLA-B HLA-C TAP1
7 MHC class Ib protein binding GO:0023029 9.32 TAP1 TAP2
8 cytokine activity GO:0005125 9.02 CD40LG IL17A IL1RN LTA TNF
9 interleukin-1, Type II receptor binding GO:0005151 8.96 ERAP1 IL1RN

Sources for Spondylitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....