MCID: SPN051
MIFTS: 59

Spondylitis malady

Summaries for Spondylitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

MalaCards: Spondylitis is related to ankylosing spondylitis and arthritis. An important gene associated with Spondylitis is TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Immune System and CDK-mediated phosphorylation and removal of Cdc6. The compounds vegf and infliximab have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Spondylitis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT
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Aliases & Descriptions:

spondylitis 8 45 61


External Ids:

Disease Ontology8 DOID:6590
ICD9CM27 720.8, 720.89

Related Diseases for Spondylitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Spondylitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 390)
idRelated DiseaseScoreTop Affiliating Genes
1ankylosing spondylitis32.1PTH, NOD2, FCAR, MMP3, TAP2, TAPBP
2arthritis31.2MMP3, IL17A, TNF, TNFSF11, TNFRSF1A
3psoriatic arthritis30.9NOD2, MMP3, CRP, TNF, TNFSF11, TNFRSF1A
4uveitis30.8NOD2, IL17A, HLA-B, TNF, TNFRSF1A, TNFRSF1B
5reactive arthritis30.6TAP2, CD79A, PRTN3, CRP, HLA-B
6crohn's disease30.5NOD2, CRP, TNF, TNFRSF1B
7amyloidosis30.5CD79A, CRP, HLA-B, TNFRSF1A
8tuberculosis30.4NOD2, IL17A, CD79A, CRP, TNF, TNFRSF1A
9atherosclerosis30.3NOD2, MMP3, IL17A, IL1RN, CD40LG, PRTN3
10vasculitis30.3IL17A, CD79A, CD40LG, PRTN3, CRP, HLA-B
11osteoporosis30.3PTH, MMP3, IL1RN, TNFSF11
12mixed connective tissue disease30.1PRTN3, TNFRSF1B
13familial mediterranean fever30.1TNF, TNFRSF1A
14epidural abscess30.1CRP
15systemic lupus erythematosus30.1NOD2, MMP3, TAP2, TAP1, IL17A, IL1RN
16ulcerative colitis30.1NOD2, MMP3, IL17A, IL1RN, CD79A, PRTN3
17osteoarthritis30.1MMP3, IL17A, IL1RN, CRP, TNF, TNFSF11
18arthropathy30.1NOD2, MMP3, IL1RN, CRP, TNF, TNFSF11
19insulin resistance30.1CRP, TNF, TNFRSF1A, TNFRSF1B, TLR4
20vascular disease30.1MMP3, IL1RN, TNF, TNFRSF1A
21polymyalgia rheumatica30.1IL1RN, CRP
22aortic aneurysm30.1CRP
23nephritis29.9IL17A, IL1RN, CD79A, CD40LG, PRTN3
24spondylarthropathy29.9CRP, TNF, TLR4
25abdominal aortic aneurysm29.9MMP3, TNFRSF1A, TNFRSF1B
26synovitis29.7MMP3, IL17A, IL1RN, CRP, TNF, TNFSF11
27squamous cell carcinoma29.7MMP3, TAP2, TAPBP, TAP1, PRTN3, HLA-B
28coronary artery disease,29.7MMP3, IL17A, CRP, TNFSF11, TNFRSF1B
29juvenile rheumatoid arthritis29.7IL1RN, CRP, TNF, TNFRSF1B
30behcet's disease29.7CRP, HLA-B, TNF, TNFRSF1B
31acute leukemia29.7IL17A, PRTN3
32adult-onset still's disease29.7CRP, TNFRSF1B
33thyroiditis29.7CD79A
34bronchiolitis29.7TLR4
35acquired immunodeficiency syndrome29.7HLA-B
36antiphospholipid syndrome29.7CD79A, CD40LG
37septic arthritis29.7CRP
38hidradenitis suppurativa29.7TNFRSF1B
39churg-strauss syndrome29.7PRTN3
40cauda equina syndrome10.6
41anterior uveitis10.5
42diffuse idiopathic skeletal hyperostosis10.4
43ankylosis10.4
44klebsiella10.4
45spondyloarthropathy10.4
46atlantoaxial subluxation10.4
47iritis10.3
48discitis10.3
49amyloidosis, secondary10.3
50temporomandibular ankylosis10.2

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to spondylitis

Clinical Features for Spondylitis

Drugs & Therapeutics for Spondylitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spondylitis

Drug clinical trials:

Search ClinicalTrials for Spondylitis

Search NIH Clinical Center for Spondylitis

Search CenterWatch for Spondylitis

Genetic Tests for Spondylitis

Anatomical Context for Spondylitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Spondylitis:

33
Bone marrow, Whole blood, Brain, Spinal cord, Heart, Skeletal muscle, Small intestine, Colon, Liver, Lung, Thyroid, Breast, Skin, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Pituitary

Animal Models for Spondylitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Spondylitis

Sources:
51PubMed
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Articles related to Spondylitis:

(show top 50)    (show all 1301)
idTitleAuthorsYear
1
Development of a health index in patients with ankylosing spondylitis (ASAS HI): final result of a global initiative based on the ICF guided by ASAS. (24399232)
2014
2
Clinical response, drug survival and predictors thereof in 432 ankylosing spondylitis patients after switching tumour necrosis factor I+ inhibitor therapy: results from the Danish nationwide DANBIO registry. (22941767)
2013
3
High disease activity in ankylosing spondylitis is associated with increased serum sclerostin level and decreased wingless protein-3a signaling but is not linked with greater structural damage. (23509994)
2013
4
The patient experience with fatigue and content validity of a measure to assess fatigue severity: qualitative research in patients with ankylosing spondylitis (AS). (24215664)
2013
5
Angioimmunoblastic T cell lymphoma in an ankylosing spondylitis patient treated with etanercept. (22791222)
2013
6
A case of ankylosing spondylitis and discussion of the literature. (23905135)
2013
7
Infliximab improves bone metabolism and bone mineral density in rheumatoid arthritis and ankylosing spondylitis: a prospective 2-year study. (23179009)
2013
8
A three-week multidisciplinary in-patient rehabilitation programme had positive long-term effects in patients with ankylosing spondylitis: randomized controlled trial. (23138412)
2013
9
Levels of circulating Th17 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti-TNF-I+ therapy. (22926407)
2013
10
Atypical mycobacterial spondylitis as a challenging differential diagnosis to metastatic disease of the spine: a case report. (23412200)
2013
11
Patient perspectives of managing fatigue in Ankylosing Spondylitis, and views on potential interventions: a qualitative study. (23659344)
2013
12
Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis. (23093722)
2013
13
The use of anti-TNF therapy for ankylosing spondylitis in everyday rheumatology practice and the relationship to disease activity, work disability and diagnostic delay. (24362820)
2013
14
A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study. (23687259)
2013
15
Thoughts and perceptions of ankylosing spondylitis patients with regard to TNF inhibitors. (24374358)
2013
16
Ankylosing spondylitis associated with Sweet's syndrome: a case report. (23305505)
2013
17
Functional limitations due to axial and peripheral joint impairments in patients with ankylosing spondylitis: are focused measures more informative? (23097327)
2013
18
Infliximab-induced psoriasis in treatment of Crohn's disease-associated ankylosing spondylitis: case report and review of 142 cases. (23986169)
2013
19
Conventional DMARD therapy (methotrexate-sulphasalazine) may decrease the requirement of biologics in routine practice of ankylosing spondylitis patients: a real-life experience. (23253235)
2012
20
High bone turnover assessed by 18F-fluoride PET/CT in the spine and sacroiliac joints of patients with ankylosing spondylitis: comparison with inflammatory lesions detected by whole body MRI. (22788874)
2012
21
Surgical orodental implications in ankylosing spondylitis. (23559963)
2012
22
Distinct impacts of syndesmophyte formation on male and female patients with ankylosing spondylitis. (22462419)
2012
23
Identification of ankylosing spondylitis-associated genes by expression profiling. (22751785)
2012
24
Urolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI). (24009925)
2012
25
Effects of genetic polymorphisms of programmed cell death 1 and its ligands on the development of ankylosing spondylitis. (21791547)
2011
26
Uncommon case of ankylosing spondylitis associated with spontaneous occurring hypoparathyroidism. (19855974)
2011
27
Correlation of HLA B27 subtypes with clinical features of ankylosing spondylitis. (22004234)
2011
28
Surgical arthritis service weekly rounds: ankylosing spondylitis. (22754423)
2011
29
Lumboperitoneal shunting of cerebrospinal fluid versus anti-tumor necrosis factor treatment of cauda equina syndrome in ankylosing spondylitis: comment on the article by Cornec et al. (20178129)
2010
30
Decrease in antioxidant status of plasma and erythrocytes from patients with ankylosing spondylitis. (20045403)
2010
31
Hematogenous spondylitis due to Aspergillus fumigatus in a patient with acquired immunodeficiency syndrome. (19386390)
2009
32
Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. (19565552)
2009
33
Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis. (18322308)
2008
34
Disparate folding and stability of the ankylosing spondylitis-associated HLA-B*1403 and B*2705 proteins. (19035480)
2008
35
Association of acute anterior uveitis with disease activity, functional ability and physical mobility in patients with ankylosing spondylitis: a cross-sectional study of Chinese patients in Taiwan. (17021671)
2007
36
C-reactive protein predicts tumor necrosis factor-alpha blocker retention rate in axial ankylosing spondylitis. (17722225)
2007
37
Retinol (vitamin A) and retinol-binding protein levels are decreased in ankylosing spondylitis: clinical and genetic analysis. (18050373)
2007
38
Major reduction in spinal inflammation in patients with ankylosing spondylitis after treatment with infliximab: results of a multicenter, randomized, double-blind, placebo-controlled magnetic resonance imaging study. (16646033)
2006
39
Decrease in serum nucleotide pyrophosphatase activity in ankylosing spondylitis. (12509614)
2003
40
Idiopathic retroperitoneal fibrosis and ankylosing spondylitis. A new case report. (12477237)
2002
41
The Crohn's associated NOD2 3020InsC frameshift mutation does not confer susceptibility to ankylosing spondylitis. (12415614)
2002
42
Focal sialadenitis in patients with ankylosing spondylitis and spondyloarthropathy: a comparison with patients with rheumatoid arthritis or mixed connective tissue disease. (11454637)
2001
43
Clinical aspects, outcome assessment, and management of ankylosing spondylitis and postenteric reactive arthritis. (10910177)
2000
44
Cutaneous necrotizing vasculitis, erythema nodosum and ankylosing spondylitis. (10378721)
1999
45
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
46
Do the radiological changes of classic ankylosing spondylitis differ from the changes found in the spondylitis associated with inflammatory bowel disease, psoriasis, and reactive arthritis? (9640127)
1998
47
HLA-DR8 and acute anterior uveitis in ankylosing spondylitis. (7718009)
1995
48
Atlantoaxial subluxation as a complication of early ankylosing spondylitis. Two cases reports and a review of the literature. (420717)
1979
49
Computerized tomography. An adjunct to early diagnosis in the cauda equina syndrome of ankylosing spondylitis. (623530)
1978
50
Traumatic proliferations of fibrocartilage with ossification in the genesis of spondylitis deformans and myositis ossificans. (18932588)
1948

Genetic Variations for Spondylitis

Expression for genes affiliated with Spondylitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for genes affiliated with Spondylitis

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 56SinoBiological, 53R&D Systems, 12EMD Millipore, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Spondylitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2TAPBP, TAP1, TAP2, CD79A, CD40LG, HLA-B
2
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11.0TNFRSF1A, PSMB9, TNF, HLA-B, TAP1, TAPBP
3
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11.0TLR4, TAP2, TNFRSF1A, TNF, HLA-B, TAP1
4
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11.0TNFRSF1A, TLR4, TNF, CD40LG, IL17A, NOD2
5
Hide members
10.9CD40LG, TNFRSF1B, TLR4, TNFRSF1A, TNF, TNFSF11
6
Hide members
10.9TAP2, TAPBP, TAP1, PSMB9, HLA-B
710.9TAP1, TAP2, PSMB9, HLA-B, TAPBP
810.9TAP2, TLR4, HLA-B, TAP1, FCAR
910.9NOD2, TNF, TNFRSF1A, TNFRSF1B, MMP3
10
Hide members
10.9HLA-B, TNFRSF1B, TNFRSF1A, TNF, CD40LG
11
Hide members
10.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, IL17A
1210.9TNFSF11, TNFRSF1A, TLR4, TNFRSF1B, TNF
13
Hide members
10.9TLR4, TNFRSF1A, TNFSF11, TNF, TNFRSF1B
14
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
10.9TNFSF11, CD40LG, TNF, TNFRSF1B, TNFRSF1A
1510.9TNF, TLR4, TNFRSF1A, TNFSF11, CD40LG
16
Hide members
10.8TAP2, TAPBP, HLA-B, TAP1
1710.8TAP1, TNFSF11, CD79A, TAP2
1810.8TNF, TLR4, NOD2, TNFRSF1A
19
Hide members
10.8TNFRSF1B, TNFRSF1A, TNFSF11, TNF
20
Hide members
10.8TNF, TNFRSF1A, TLR4, TNFRSF1B
2110.8TNF, TLR4, TNFRSF1B, TNFRSF1A
2210.7PSMB9, TAP1, HLA-B
23
Hide members
10.7TAP1, TAPBP, TAP2
24
Development Thrombopoetin signaling via JAK-STAT pathway
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10.7CRP, IL1RN, TAP1
2510.7TNFRSF1A, NOD2, TNF
26
Hide members
10.7IL17A, CD79A, CD40LG
27
Hide members
10.7IL17A, TLR4, TNF
28
Hide members
10.7TNF, TNFRSF1B, TNFRSF1A
2910.7TNFRSF1B, TNF, TNFRSF1A
30
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.7TNFRSF1A, TNF, TNFRSF1B
31
Hide members
10.7TNFRSF1A, TNFRSF1B, TNF
3210.7TNF, TNFRSF1A, TNFRSF1B
3310.7TNFRSF1B, TNFRSF1A, TNF
34
Hide members
10.7TNFRSF1A, TNF, TNFRSF1B
35
Immune response Bacterial infections in normal airways
Hide members
10.7TNF, IL1RN, TLR4
3610.7CD40LG, TNFRSF1B, TNFRSF1A
3710.6TAP1, CD79A
38
Hide members
10.6TNFRSF1A, TNF
39
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.6TNFSF11, PTH
4010.6TNFSF11, TLR4
4110.6TLR4

Compounds for genes affiliated with Spondylitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Spondylitis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1vegf4511.9CD40LG, IL17A, IL1RN, TLR4, PTH, TNFRSF1B
2infliximab45 50 1113.8TLR4, IL17A, MMP3, NOD2, TNFRSF1B, TNFRSF1A
3alanine4511.8CRP, MMP3, IL1RN, CD40LG, CD79A, TNFRSF1A
4retinoic acid45 2412.7CD40LG, CD79A, TLR4, IL1RN, TAPBP, PRTN3
5lipid4511.7HLA-B, TNF, TNFRSF1A, TLR4, TNFRSF1B, CRP
6nitric oxide45 11 2413.7IL1RN, NOD2, PTH, HLA-B, TNFRSF1A, IL17A
7serine4511.6TLR4, NOD2, MMP3, TNF, IL1RN, PRTN3
8methotrexate45 50 1113.6IL17A, MMP3, TNF, IL1RN, CD79A, TNFRSF1B
9creatinine4511.6MMP3, CRP, TNFSF11, TNFRSF1A, CD79A, IL1RN
10etanercept45 50 1113.6TNF, TNFSF11, TNFRSF1A, TNFRSF1B, CRP, IL1RN
11testosterone45 60 11 2414.5HLA-B, PTH, IL1RN, CD79A, CD40LG, TNFRSF1B
12n acetylcysteine4511.5CD40LG, TNFSF11, CRP, CD79A, TNF, MMP3
13sb 20358045 6012.5MMP3, TNF, TLR4, TNFRSF1A, TNFSF11, CRP
14fibrinogen4511.5TNF, IL1RN, CD79A, CD40LG, TNFRSF1B, HLA-B
15ivig4511.5CD79A, CD40LG, IL1RN, CRP, TNF, TNFRSF1A
16neopterin4511.5IL1RN, CD79A, CRP, TNF, TNFRSF1A, TNFRSF1B
17p0024511.4MMP3, TNFRSF1B, IL17A, IL1RN, PRTN3, CRP
18calcium45 50 11 2414.4CRP, PTH, NOD2, TLR4, IL1RN, TAP2
19lactate4511.4MMP3, CD40LG, CD79A, TLR4, CRP, TNF
20rantes4511.4TLR4, TNF, HLA-B, CD40LG, IL17A, TNFRSF1A
21cyclosporin a45 29 6013.4CD40LG, TNFRSF1B, IL17A, CD79A, HLA-B, TNFSF11
22dexamethasone45 50 29 1114.4TNFRSF1B, TLR4, PTH, TNFSF11, CD40LG, CD79A
23sulfasalazine45 29 50 1114.4MMP3, CD79A, TNF, CD40LG, CRP, IL1RN
24chloroquine45 2 50 29 1115.3IL1RN, CD79A, TNF, TNFRSF1B, TLR4, TNFRSF1A
25polyethylene glycol4511.3TNFRSF1B, CRP, CD40LG, CD79A, IL1RN, TNFRSF1A
26oxygen45 2412.3PRTN3, FCAR, TNF, TNFRSF1B, TNFRSF1A, TNFSF11
27adalimumab45 50 1113.3TNF, CRP, CD79A, IL1RN, MMP3
28leflunomide50 45 1113.3TNF, TNFSF11, TNFRSF1A, MMP3, IL1RN
29tyrosine4511.2HLA-B, TNFSF11, TNFRSF1A, PTH, FCAR, MMP3
30okt34511.2TNFRSF1A, TNF, CD79A, CRP, CD40LG
31ns 39845 6012.2TNFRSF1A, TNFSF11, IL17A, TNF, IL1RN
32vitamin d4511.2TNFRSF1B, TNFSF11, CD79A, MMP3, TLR4, PTH
33simvastatin45 50 60 29 11 2416.2CRP, IL1RN, TNFRSF1A, MMP3, TNF, TLR4
34mannose4511.2TLR4, NOD2, CD79A, FCAR, IL17A, IL1RN
35il 104511.2NOD2, TNF, TNFRSF1B, IL1RN, TLR4
36peptidoglycan45 2912.1TLR4, NOD2, TNFSF11, TNF, IL1RN
37prednisolone45 29 1113.1CRP, CD79A, MMP3, NOD2
38pneumococcal4511.1TLR4, HLA-B, CD40LG, CD79A
39prostaglandin4511.1MMP3, IL17A, TNFSF11, TNF, IL1RN, PTH
40superoxide45 2412.1TNFRSF1B, TNF, FCAR, TNFRSF1A
41blys4511.1TNFRSF1A, TNF, CD40LG, CD79A
42endotoxin4511.1TNFRSF1B, TNFRSF1A
43rituximab45 50 1113.1TNF, CD79A, CD40LG, PRTN3, CRP
44estrogen4511.0TNFRSF1B, CD79A, PRTN3
45cycloheximide4511.0PTH
46fmlp4510.9TNFRSF1B, PRTN3, IL1RN
47h2o24510.9TNFRSF1B, TNFRSF1A, CD79A, IL1RN
48tacrolimus45 50 1112.8IL17A, TNFSF11, CD79A
49pmma4510.8CD79A, CD40LG, TNFSF11, CRP
50forskolin45 50 1112.3TAP2, PTH

GO Terms for genes affiliated with Spondylitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Spondylitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.7CRP, HLA-B, TNF, TNFRSF1A, TNFRSF1B, TLR4
2extracellular spaceGO:00561511.3PTH, TNFRSF1A, TNFSF11, TNF, CRP, CD40LG
3integral to plasma membraneGO:00588711.0TNFRSF1A, TNFSF11, TNF, HLA-B, CD40LG, FCAR
4external side of plasma membraneGO:00989710.9IL17A, CD79A, CD40LG, TNF, TLR4
5extracellular regionGO:00557610.8TNFRSF1B, TNFRSF1A, TNFSF11, TNF, CRP, MMP3
6TAP complexGO:04282510.8TAP1, TAPBP, TAP2
7membrane raftGO:04512110.7TNFRSF1B, TNFRSF1A, TNF, CD79A

Biological processes related to Spondylitis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.5HLA-B, TNFRSF1B, IL1RN, IL17A, TAPBP, FCAR
2inflammatory responseGO:00695411.3IL17A, TNFRSF1B, TNFRSF1A, TNF, CRP, CD40LG
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247911.3TAP2, TAP1, HLA-B, TAPBP, PSMB9
4antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259011.3TAP2, TAPBP, TAP1, HLA-B, PSMB9
5antigen processing and presentation of peptide antigen via MHC class IGO:00247411.3TAP2, PSMB9, HLA-B, TAP1, TAPBP
6positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312311.2TNFRSF1A, TLR4, NOD2, TNF, TNFSF11
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.2TLR4, TNFRSF1A, TNFSF11, TNF, IL17A, PTH
8positive regulation of JNK cascadeGO:04633011.2NOD2, TNF, TLR4, TNFSF11
9defense responseGO:00695211.1NOD2, TAPBP, TAP1, HLA-B
10positive regulation of NF-kappaB transcription factor activityGO:05109211.1NOD2, TNFSF11, TNF, TLR4
11antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988511.1TAP1, TAPBP, TAP2
12positive regulation of osteoclast differentiationGO:04567211.1TNF, TNFSF11, IL17A
13positive regulation of T cell mediated cytotoxicityGO:00191611.0TAP1, TAP2, HLA-B
14negative regulation of interleukin-6 productionGO:03271511.0TNFRSF1A, TLR4, TNF
15positive regulation of interleukin-12 productionGO:03273511.0NOD2, CD40LG, TLR4
16positive regulation of tumor necrosis factor productionGO:03276011.0TLR4, TNFRSF1A, NOD2
17defense response to Gram-positive bacteriumGO:05083011.0CRP, NOD2, TNF
18positive regulation of interleukin-6 productionGO:03275511.0NOD2, TNF, TLR4
19cytosol to ER transportGO:04696710.9TAP1, TAP2
20chronic inflammatory response to antigenic stimulusGO:00243910.9TNF, IL1RN
21regulation of immunoglobulin secretionGO:05102310.8CD40LG, TNF
22intracellular transport of viral proteins in host cellGO:01906010.8TAP2, TAP1
23peptide transportGO:01583310.8TAP2, TAP1
24positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8NOD2, TNF
25activation of MAPK activityGO:00018710.7NOD2, TLR4, TNF
26negative regulation of lipid storageGO:01088810.7CRP, TNF
27positive regulation of interleukin-8 biosynthetic processGO:04541610.6TNF, TLR4
28positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.5NOD2, TLR4
29B cell proliferationGO:04210010.3CD79A, CD40LG

Molecular functions related to Spondylitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:04260511.0HLA-B, TAP1, TAPBP, TAP2
2TAP1 bindingGO:04697811.0TAP2, TAPBP, TAP1
3TAP2 bindingGO:04697910.9TAP2, TAPBP, TAP1
4MHC class I protein bindingGO:04228810.9TAP2, TAPBP, TAP1
5tumor necrosis factor receptor bindingGO:00516410.9TNFSF11, TNF, CD40LG
6peptide antigen-transporting ATPase activityGO:01543310.8TAP2, TAPBP
7peptide transporter activityGO:01519710.7TAP2, TAP1
8tapasin bindingGO:04698010.6TAP2, TAP1
9tumor necrosis factor-activated receptor activityGO:00503110.6TNFRSF1A, TNFRSF1B
10oligopeptide-transporting ATPase activityGO:01542110.5TAP1, TAP2
11cytokine activityGO:00512510.5IL17A, CD40LG, TNF, TNFSF11

Products for genes affiliated with Spondylitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet