Aliases & Classifications for Spondylitis

MalaCards integrated aliases for Spondylitis:

Name: Spondylitis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6590
ICD10 33 M46
ICD9CM 35 720.8 720.89
SNOMED-CT 64 202651004 202653001
UMLS 69 C0029644

Summaries for Spondylitis

MalaCards based summary : Spondylitis is related to aseptic meningitis and cutaneous leishmaniasis, and has symptoms including sciatica An important gene associated with Spondylitis is MICA (MHC Class I Polypeptide-Related Sequence A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Adalimumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Wikipedia : 72 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

Related Diseases for Spondylitis

Diseases related to Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 389)
id Related Disease Score Top Affiliating Genes
1 aseptic meningitis 30.2 HLA-B TAP2 TNF
2 cutaneous leishmaniasis 30.1 IL6 TNF
3 discitis 30.0 CD40LG TNF TNFRSF1B
4 lymphoma 29.1 CD40LG IL17A IL6 TNF
5 atherosclerosis 28.3 IL17A IL6 LTA MICA NOD2 TNF
6 systemic lupus erythematosus 27.6 CD40LG CRP IL17A IL6 LTA TNF
7 rheumatoid arthritis 27.4 CD40LG CHI3L1 CRP HLA-B IL17A IL6
8 spondyloarthropathy 1 12.1
9 gonococcal spondylitis 11.8
10 psoriatic arthritis 11.2
11 spinal disease 11.1
12 postinfectious vasculitis 10.8 TAP1 TAP2
13 kummell's disease 10.8
14 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
15 temporomandibular ankylosis 10.8
16 ossification of the posterior longitudinal ligament of spine 10.8
17 antigen-peptide-transporter 2 deficiency 10.7 HLA-B IL6 TNF
18 ehlers-danlos syndrome due to tenascin x deficiency 10.7 MICA TAP1 TAP2
19 cyclosporiasis 10.7 HLA-B IL6 TNF
20 lens-induced iridocyclitis 10.7 HLA-B HLA-C
21 migraine with brainstem aura 10.7 HLA-B TNF
22 noma 10.7 HLA-B IL6 TNF
23 aortic arch interruption 10.7 IL6 TNF
24 collagenopathy type 2 alpha 1 10.7 CRP IL6
25 high pressure neurological syndrome 10.6 HLA-B IL6 TNF
26 idiopathic dilatation of the pulmonary artery 10.6 IL23R LTA TNF
27 anaerobic meningitis 10.6 HLA-B HLA-C TNF
28 spirillary rat-bite fever 10.6 IL6 LTA TNF
29 toxoplasmosis 10.6 IL6 LTA TNF
30 epstein-barr virus hepatitis 10.6 CRP IL6 TNF
31 cicatricial lagophthalmos 10.6 CRP IL6 TNF
32 kernicterus due to isoimmunization 10.6 HLA-C LTA TNF
33 islet cell tumor 10.6 CRP IL6 TNF
34 deafness, autosomal recessive 67 10.6 MICA NOD2 TNF
35 placental abruption 10.6 CRP IL6 TNF
36 benign neonatal seizures 10.6 CRP IL6 TNF
37 myeloid sarcoma 10.6 CRP IL6 TNF
38 breast disease 10.5 CRP IL6 TNF
39 heterotaxy, visceral, 4, autosomal 10.5 HLA-B HLA-C IL6
40 adenocarcinoid tumor 10.5 IL6 LTA TNF
41 bardet-biedl syndrome 8 10.5 CRP IL6 TNF
42 pancreas lymphoma 10.5 CRP IL6 TNF
43 legionellosis 10.5 IL6 LTA TNF
44 choroiditis 10.5 CRP IL6 TNF
45 endocervical type cervical mucinous adenocarcinoma 10.5 CRP IL6 TNF
46 neonatal period electroclinical syndrome 10.5 CRP IL6 TNF
47 colon adenocarcinoma 10.5 CRP IL6 TNF
48 blue toe syndrome 10.5 IL6 LTA TNF
49 mixed mineral dust pneumoconiosis 10.5 CRP IL6 TNF
50 neovascular glaucoma 10.5 CRP IL6 TNF

Comorbidity relations with Spondylitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to Spondylitis

Symptoms & Phenotypes for Spondylitis

UMLS symptoms related to Spondylitis:


sciatica

GenomeRNAi Phenotypes related to Spondylitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.22 HLA-C HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.22 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.22 HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.22 HLA-C HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.22 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.22 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.22 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.22 HLA-B HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.22 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.22 NOD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.22 NOD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.22 HLA-B HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.22 NOD2 MICA HLA-B HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.22 NOD2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.22 HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.22 NOD2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.22 HLA-B HLA-C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.22 NOD2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.22 NOD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.22 MICA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.22 HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.22 MICA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.22 HLA-C HLA-B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.22 HLA-C HLA-B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.22 MICA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.22 HLA-C
27 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL17A LTA NOD2 SNAPC4 TNF TNFRSF1B
28 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 LTA NOD2 SNAPC4 TNF TNFRSF1B CD40LG

MGI Mouse Phenotypes related to Spondylitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 IL17A IL23R IL6 LTA NOD2 TAP1
2 immune system MP:0005387 9.8 ANTXR2 CD40LG CHI3L1 CRP ERAP1 IL17A
3 skeleton MP:0005390 9.28 CD40LG IL17A IL6 LTA NOD2 SNAPC4

Drugs & Therapeutics for Spondylitis

Drugs for Spondylitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 263)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
2
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
3
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
4
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
5
Pamidronate Approved Phase 4,Phase 1,Phase 2 40391-99-9 4674
6
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
7
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
8
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
9
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
10
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
11
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
12
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
13
Aceclofenac Approved Phase 4 89796-99-6
14
Acetaminophen Approved Phase 4,Early Phase 1 103-90-2 1983
15
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
16
Rifampin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
17
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
18
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
19
Ethambutol Approved Phase 4 74-55-5 3279 14052
20
Isoniazid Approved Phase 4 54-85-3 3767
21
Pyrazinamide Approved Phase 4 98-96-4 1046
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
24 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
25 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
26 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
28 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
29 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
31 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Natriuretic Agents Phase 4
33 Natriuretic Peptide, Brain Phase 4
34 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Antacids Phase 4,Phase 3,Phase 1
36 Anti-Ulcer Agents Phase 4,Phase 3,Phase 1
37 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Phase 1
38 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
39
Proton pump inhibitors Phase 4,Phase 3,Phase 1
40 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
41 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
42 Vaccines Phase 4,Phase 2
43 Adrenocorticotropic Hormone Phase 4
44 beta-endorphin Phase 4
45 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
46 Hormones Phase 4,Phase 2,Phase 3,Phase 1
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
48 Melanocyte-Stimulating Hormones Phase 4
49 Anti-Infective Agents Phase 4,Phase 2,Phase 3
50 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 566)

id Name Status NCT ID Phase Drugs
1 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
2 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
3 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
4 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
5 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
6 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
7 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
8 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
9 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
10 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
11 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
12 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
13 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
14 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
15 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
16 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
17 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4 Enbrel
18 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
19 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
20 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4 Etanercept
21 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
22 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4 Etanercept
23 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
24 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
25 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
26 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
27 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
28 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4 alendronate
29 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
30 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
31 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
32 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4 Infliximab; observational study;Methotrexate; observational study
33 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
34 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
35 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
36 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
37 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
38 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
39 Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis Completed NCT01029847 Phase 4 Adalimumab;Placebo
40 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
41 Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 4
42 A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis Completed NCT01298531 Phase 4 etanercept;etanercept;placebo
43 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
44 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
45 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
46 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4 etanercept
47 A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics Completed NCT02470481 Phase 4
48 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4 Adalimumab
49 National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study Completed NCT01123265 Phase 4 Methotrexate;Anti-TNF
50 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4 Infliximab;Etanercept

Search NIH Clinical Center for Spondylitis

Genetic Tests for Spondylitis

Anatomical Context for Spondylitis

MalaCards organs/tissues related to Spondylitis:

39
Bone, Testes, T Cells, Endothelial, Heart, Skin, B Cells

Publications for Spondylitis

Articles related to Spondylitis:

(show top 50) (show all 1637)
id Title Authors Year
1
The potent suppressive effect of I^-d-mannuronic acid (M2000) on molecular expression of the TLR/NF-kB Signaling Pathway in ankylosing spondylitis patients. ( 28938189 )
2017
2
Single nucleotide polymorphisms of ABCB1 gene and response to etanercept treatment in patients with ankylosing spondylitis in a Chinese Han population. ( 28151874 )
2017
3
Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis. ( 28901420 )
2017
4
TNF blockers inhibit spinal radiographic progression in ankylosing spondylitis by reducing disease activity: results from the Swiss Clinical Quality Management cohort. ( 28939631 )
2017
5
Necrotizing fasciitis of the lower leg caused by Escherichia coli, and an association with pyogenic spondylitis. ( 28925014 )
2017
6
Phlegmonous gastritis in an ankylosing spondylitis patient treated with infliximab. ( 28814069 )
2017
7
Pleural Tuberculosis following Infliximab Therapy for Ankylosing Spondylitis. ( 28405137 )
2017
8
Evaluation of auditory and cochlear functions in ankylosing spondylitis patients according to the site of involvement. ( 28889257 )
2017
9
Association between use of disease-modifying antirheumatic drugs and diabetes in patients with ankylosing spondylitis, rheumatoid arthritis, or psoriasis/psoriatic arthritis: a nationwide, population-based cohort study of 84,989 patients. ( 28496328 )
2017
10
Transpseudarthrosis Osteotomy with Interbody Fusion for Kyphotic Spinal Pseudarthrosis in Ankylosing Spondylitis by a Single Posterior Approach: A Retrospective Study and a Brief Relevant Literature Review. ( 28875150 )
2017
11
Mannose-binding lectin (MBL) deficiency and tuberculosis infection in patients with ankylosing spondylitis. ( 28879439 )
2017
12
Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers. ( 28042135 )
2017
13
TNFR1 -383 AE8C polymorphism and ankylosing spondylitis in a Russian Caucasian population: a preliminary study. ( 28363009 )
2017
14
Spontaneous bilateral quadriceps rupture in a patient with ankylosing spondylitis: A case report. ( 28065978 )
2017
15
Comparison of Outcomes of Total Hip Arthroplasty between Patients with Ankylosing Spondylitis and Avascular Necrosis of the Femoral Head. ( 28861192 )
2017
16
The effects of balance and postural stability exercises on spa based rehabilitation programme in patients with ankylosing spondylitis. ( 28946534 )
2017
17
Epidural Haematoma Causing Paraplegia in a Patient with Ankylosing Spondylitis: A Case Report. ( 28824860 )
2017
18
Increased expression of TIPE2 mRNA in PBMCs of patients with ankylosing spondylitis is negatively associated with the disease severity. ( 27816498 )
2017
19
Perioperative Blood Loss During Total Hip Arthroplasty Among Patients With Ankylosing Spondylitis. ( 28877325 )
2017
20
rs657075 (CSF2) Is Associated with the Disease Phenotype (BAS-G) of Ankylosing Spondylitis. ( 28054948 )
2017
21
Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study. ( 28521824 )
2017
22
Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway. ( 28941122 )
2017
23
ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations. ( 28049827 )
2017
24
Down-Regulation of lncRNA-AK001085 and its Influences on the Diagnosis of Ankylosing Spondylitis. ( 28042142 )
2017
25
Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. ( 27125523 )
2017
26
Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. ( 28225768 )
2017
27
Increased Levels of Oxidative Stress Markers, Soluble CD40 Ligand, and Carotid Intima-Media Thickness Reflect Acceleration of Atherosclerosis in Male Patients with Ankylosing Spondylitis in Active Phase and without the Classical Cardiovascular Risk Factors. ( 28883908 )
2017
28
Evaluation of the internal oblique, external oblique, and transversus abdominalis muscles in patients with ankylosing spondylitis: an ultrasonographic study. ( 28891005 )
2017
29
Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome. ( 28063628 )
2017
30
Influence of CYP2C9 and COX-2 Genetic Polymorphisms on Clinical Efficacy of Non-Steroidal Anti-Inflammatory Drugs in Treatment of Ankylosing Spondylitis. ( 28403136 )
2017
31
The reliability and validity of a Venezuelan version of the Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). ( 28943073 )
2017
32
Assessment of semaphorin 3A and its role in bone remodelling in a group of ankylosing spondylitis patients. ( 27782869 )
2017
33
Prevalence of Ankylosing Spondylitis Disease Activity Score (ASDAS) inactive disease in a cohort of patients treated with TNF-alpha inhibitors. ( 28880727 )
2017
34
Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis. ( 28743287 )
2017
35
Aquaporin-1 expression as an indicator in evaluating the efficacy of meloxicam in the treatment of ankylosing spondylitis: A comparative study. ( 28950654 )
2017
36
The genetic association between polymorphisms in lymphotoxin-I+ gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study. ( 28489756 )
2017
37
Clinical utility of the ASDAS index in comparison with BASDAI in patients with ankylosing spondylitis (Axis Study). ( 28918450 )
2017
38
Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort. ( 28607176 )
2017
39
Single nucleotide polymorphisms of autophagy-related 16-like 1 gene are associated with ankylosing spondylitis in females: a case-control study. ( 28952203 )
2017
40
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. ( 28069576 )
2017
41
Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism. ( 28912853 )
2017
42
Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis. ( 28381868 )
2017
43
Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial. ( 28079501 )
2017
44
Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression. ( 27515058 )
2017
45
Relationship between the gut and the spine: a pilot study of first-degree relatives of patients with ankylosing spondylitis. ( 28879050 )
2017
46
Secular trends in sickness absence among Swedish patients with ankylosing spondylitis and psoriatic arthritis. ( 28879599 )
2017
47
Sacroiliitis and Spondylitis with Sternoclavicular Hyperostosis: SAPHO or an Ankylosing Spondylitis Variant? ( 26712445 )
2016
48
Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis. ( 27538101 )
2016
49
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis. ( 26130142 )
2016
50
Distinct expression of chemokine-like factor 1 in synovium of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. ( 26838743 )
2016

Variations for Spondylitis

Expression for Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for Spondylitis

Pathways related to Spondylitis according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CD40LG CHI3L1 CRP ERAP1 ERAP2 HLA-B
2
Show member pathways
13.41 CD40LG ERAP1 ERAP2 HLA-B HLA-C MICA
3
Show member pathways
13.25 CD40LG IL17A IL23R IL6 LTA TNF
4
Show member pathways
13.18 CD40LG HLA-B HLA-C IL17A IL23R IL6
5
Show member pathways
12.69 HLA-B HLA-C IL6 LTA TAP1 TAP2
6
Show member pathways
12.65 CD40LG IL6 LTA TNF TNFRSF1B
7
Show member pathways
12.53 IL17A IL23R IL6 NOD2 TNF
8 12.45 CD40LG IL17A TAP1 TAP2 TNF TNFRSF1B
9
Show member pathways
12.4 CD40LG HLA-B HLA-C IL17A IL6 LTA
10
Show member pathways
12.37 CD40LG IL17A IL6 TNF
11 12.36 HLA-B HLA-C IL6 LTA TNF
12 12.07 HLA-B HLA-C TAP1 TAP2
13 12.02 CD40LG HLA-B HLA-C MICA
14
Show member pathways
11.94 HLA-B HLA-C IL17A IL6 LTA TNF
15 11.89 IL17A IL23R IL6 TNF TNFRSF1B
16
Show member pathways
11.84 IL17A IL23R IL6
17 11.84 IL6 LTA NOD2 TNF TNFRSF1B
18 11.78 IL17A IL6 TNF
19
Show member pathways
11.78 CD40LG LTA TNF TNFRSF1B
20
Show member pathways
11.75 IL17A IL23R IL6 LTA TNF
21 11.74 IL17A IL23R LTA TNF
22
Show member pathways
11.69 CD40LG TNF TNFRSF1B
23 11.64 CD40LG IL6 LTA TNF
24
Show member pathways
11.61 CD40LG IL6 TNF
25 11.53 LTA TNF TNFRSF1B
26
Show member pathways
11.49 LTA TNF TNFRSF1B
27 11.48 IL6 TNF TNFRSF1B
28 11.47 CD40LG IL6 TNF
29 11.32 CD40LG TAP1 TAP2
30 11.25 IL17A IL6 TNF
31 11.14 CD40LG IL17A IL6 LTA TNF
32 10.98 CRP IL6 TNF
33 10.5 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2

GO Terms for Spondylitis

Cellular components related to Spondylitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 CD40LG CHI3L1 CRP ERAP1 IL17A IL6
2 external side of plasma membrane GO:0009897 9.72 ANTXR2 CD40LG IL17A IL6 TNF
3 MHC class I protein complex GO:0042612 9.43 HLA-B HLA-C
4 TAP complex GO:0042825 9.37 TAP1 TAP2
5 phagocytic vesicle membrane GO:0030670 9.26 HLA-B HLA-C TAP1 TAP2
6 cell surface GO:0009986 9.17 ANTXR2 CD40LG HLA-B HLA-C MICA NOD2
7 endoplasmic reticulum GO:0005783 10.01 ANTXR2 CHI3L1 ERAP1 ERAP2 HLA-B HLA-C
8 extracellular region GO:0005576 10 ANTXR2 CD40LG CHI3L1 CRP ERAP1 IL17A

Biological processes related to Spondylitis according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.93 HLA-B HLA-C TAP1 TAP2
2 adaptive immune response GO:0002250 9.93 ERAP1 ERAP2 TAP1 TAP2
3 regulation of immune response GO:0050776 9.92 CD40LG HLA-B HLA-C MICA
4 immune response GO:0006955 9.92 CD40LG HLA-B HLA-C IL17A IL6 LTA
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CHI3L1 IL6 NOD2 TNF
6 response to lipopolysaccharide GO:0032496 9.9 IL23R IL6 LTA TNFRSF1B
7 immune system process GO:0002376 9.86 ERAP1 ERAP2 HLA-B HLA-C IL23R NOD2
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 CD40LG IL6 NOD2 TNF
9 cellular response to interleukin-1 GO:0071347 9.82 CHI3L1 IL17A IL6
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.81 CD40LG LTA TNF TNFRSF1B
11 response to mechanical stimulus GO:0009612 9.8 CHI3L1 IL6 SOST
12 positive regulation of T cell proliferation GO:0042102 9.79 CD40LG IL23R IL6
13 humoral immune response GO:0006959 9.77 IL6 LTA TNF
14 defense response to Gram-positive bacterium GO:0050830 9.76 CRP IL6 LTA TNF
15 inflammatory response GO:0006954 9.76 CD40LG CHI3L1 CRP IL17A IL23R IL6
16 positive regulation of interleukin-6 production GO:0032755 9.74 IL6 NOD2 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.72 IL23R LTA TNF
18 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 HLA-B HLA-C TAP1 TAP2
19 positive regulation of interleukin-17 production GO:0032740 9.65 IL23R NOD2
20 peptide transport GO:0015833 9.65 TAP1 TAP2
21 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.64 HLA-B HLA-C
22 positive regulation of osteoclast differentiation GO:0045672 9.61 IL17A IL23R TNF
23 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 IL6 TNF
24 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.58 TAP1 TAP2
25 regulation of immunoglobulin secretion GO:0051023 9.56 CD40LG TNF
26 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
27 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.52 LTA TNF
28 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.49 LTA TNF
29 cytosol to ER transport GO:0046967 9.48 TAP1 TAP2
30 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.26 ERAP1 ERAP2 TAP1 TAP2
31 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.1 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2

Molecular functions related to Spondylitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC protein binding GO:0042287 9.46 TAP1 TAP2
2 interleukin-6 receptor binding GO:0005138 9.43 ERAP1 IL6
3 peptide-transporting ATPase activity GO:0015440 9.4 TAP1 TAP2
4 TAP1 binding GO:0046978 9.37 TAP1 TAP2
5 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG LTA TNF
6 peptide transporter activity GO:0015197 9.32 TAP1 TAP2
7 MHC class Ib protein binding GO:0023029 9.26 TAP1 TAP2
8 peptide antigen binding GO:0042605 9.13 HLA-B HLA-C TAP1
9 cytokine activity GO:0005125 9.02 CD40LG IL17A IL6 LTA TNF
10 protein binding GO:0005515 10.38 ANTXR2 CD40LG CRP ERAP1 HLA-B HLA-C

Sources for Spondylitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....