MCID: SPN051
MIFTS: 57

Spondylitis malady

Bone diseases category
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Summaries for Spondylitis

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65Wikipedia, 33MalaCards
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Fully expand this MalaCard
Wikipedia:65 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

MalaCards: Spondylitis is related to ankylosing spondylitis and arthritis. An important gene associated with Spondylitis is TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Type II interferon signaling (IFNG) and Primary immunodeficiency. The compounds lactulose and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and endothelial, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Spondylitis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

spondylitis 8 45 62


External Ids:

Disease Ontology8 DOID:6590
ICD9CM27 720.89, 720.8

Related Diseases for Spondylitis

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17GeneCards, 18GeneDecks
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Diseases related to Spondylitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1ankylosing spondylitis31.4HLA-B, TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH
2arthritis31.1TNFRSF1A, IL17A, MMP3, TNFSF11, TNF
3psoriatic arthritis30.9TNFRSF1B, CRP, TNF
4reactive arthritis30.7HLA-B, CRP, CD79A, TAP2
5uveitis30.7TNF, TNFRSF1B, NOD2, TNFRSF1A, IL17A, HLA-B
6rheumatoid arthritis30.6CD79A, NOD2, TAP2, CRP, IL17A, TNFRSF1A
7amyloidosis30.5CD79A, HLA-B, TNFRSF1A, CRP
8crohn's disease30.5CRP, NOD2, TNF, TNFRSF1B
9inflammatory bowel disease30.5TNFRSF1A, CD79A
10epidural abscess30.4CRP
11pneumonia30.4CD79A, TNFRSF1B, TNF, IL17A, CRP
12osteoporosis30.4TNFSF11, PTH, MMP3
13spondylarthropathy30.3TNF, CRP
14connective tissue disease30.3TNF, CD79A
15systemic lupus erythematosus30.3CRP
16atherosclerosis30.2MMP3, NOD2, CRP, IL17A, TNF, CHI3L1
17vasculitis30.2CRP, CD79A, HLA-B, IL17A, TNF, TNFRSF1B
18familial mediterranean fever30.2TNF, TNFRSF1A
19psoriasis30.2NOD2, HLA-B, TNFRSF1B, TNF, TNFRSF1A, IL17A
20tuberculosis30.2CD79A, TNFRSF1B, TNF, NOD2, IL17A, CRP
21meningitis30.1CD79A, HLA-B, CRP
22ulcerative colitis30.0NOD2, CRP, TNF
23sarcoidosis30.0CHI3L1, NOD2, TAP2, TAP1, TNFRSF1B, TNF
24dermatitis30.0TNFRSF1B, IL17A, NOD2, CD79A
25insulin resistance30.0CRP, TNF, TNFRSF1A, TNFRSF1B
26abdominal aortic aneurysm29.9TNFRSF1B, TNFRSF1A, MMP3
27vascular disease29.9TNF, MMP3, TNFRSF1A
28brucellosis29.9CD79A
29arthropathy29.9TNF, MMP3, CRP, NOD2, TNFRSF1B, TNFSF11
30dermatitis herpetiformis29.9MMP3, CD79A
31adult-onset still's disease29.8TNFRSF1B, CRP
32osteomyelitis29.8TNFSF11, CRP
33multiple sclerosis29.7HLA-B, TNF, TAP2, TAP1, IL17A, TNFRSF1A
34breast cancer29.7MMP3, TAP1, HLA-B, TAP2, TNFRSF1B
35osteoarthritis29.7IL17A, CRP, CHI3L1, MMP3, TNF, TNFRSF1B
36behcet's disease29.7TNFRSF1B, TNF, HLA-B, CRP
37periodontitis29.7IL17A, TNF, MMP3, TNFSF11
38hodgkin's lymphoma29.7PSMB9, TNFRSF1A, HLA-B, TNFRSF1B
39cerebrovascular disease29.7CRP, TNFRSF1A, TNFRSF1B, HLA-B
40coronary artery disease29.7CRP, MMP3, TNFSF11, IL17A, TNFRSF1B
41myeloma29.6TNFSF11, CD79A, TNFRSF1B, TNFRSF1A, HLA-B
42leukemia29.6HLA-B, CD79A, TNF, TAP1, TAP2, TNFRSF1A
43synovitis29.4TNFRSF1B, TNF, IL17A, TNFSF11, TNFRSF1A, MMP3
44cauda equina syndrome10.6
45anterior uveitis10.5
46hyperostosis10.5
47diffuse idiopathic skeletal hyperostosis10.5
48cervicitis10.4
49ankylosis10.4
50spondyloarthropathy10.4

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to spondylitis

Symptoms for Spondylitis

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Drugs & Therapeutics for Spondylitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Spondylitis

Search NIH Clinical Center for Spondylitis

Genetic Tests for Spondylitis

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Anatomical Context for Spondylitis

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33MalaCards
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MalaCards organs/tissues related to Spondylitis:

33
Bone, T cells, Endothelial, Testes, Eye, Whole blood, Heart, Myeloid, Monocytes, Bone marrow, Skin, Pituitary, Thyroid, Liver, Colon, Brain, B cells, Spinal cord, Nk cells, Lung, Breast

Animal Models for Spondylitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Spondylitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0TAP1, PSMB9, TNFRSF1A, TNF, TNFRSF1B
2MP:00053906.7TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH, MMP3
3MP:00107686.3HLA-B, TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH
4MP:00053766.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH, MMP3
5MP:00053974.7NOD2, TAP2, TAPBP, TAP1, IL17A, PSMB9
6MP:00053874.5CD79A, HLA-B, NOD2, TAP2, TAPBP, TAP1

Publications for Spondylitis

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52PubMed
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Articles related to Spondylitis:

(show top 50)    (show all 1292)
idTitleAuthorsYear
1
Antitumour necrosis factor I+ treatment reduces retinol-binding protein 4 serum levels in non-diabetic ankylosing spondylitis patients. (24323393)
2013
2
Clinical response, drug survival and predictors thereof in 432 ankylosing spondylitis patients after switching tumour necrosis factor I+ inhibitor therapy: results from the Danish nationwide DANBIO registry. (22941767)
2013
3
Trends of ankylosing spondylitis ossification. (23864924)
2013
4
MICA, a gene contributing strong susceptibility to ankylosing spondylitis. (23727634)
2013
5
Surgical management of contiguous multilevel thoracolumbar tuberculous spondylitis. (22892706)
2013
6
Comparison of two referral strategies for diagnosis of axial spondyloarthritis: the Recognising and Diagnosing Ankylosing Spondylitis Reliably (RADAR) study. (23065731)
2013
7
Association between ED in ankylosing spondylitis: a population-based study. (23552581)
2013
8
Airway management in cervical spine ankylosing spondylitis: Between a rock and a hard place. (24403620)
2013
9
Usage of Conventional PCR Technology for the Detection of HLA-B27 Allele: A Significant Molecular Marker of Ankylosing Spondylitis. (24426208)
2013
10
Morphometric Vertebral Assessments via the Use of Dual X-ray Absorptiometry for the Evaluation of Radiographic Damage in Ankylosing Spondylitis: A Pilot Study. (24161790)
2013
11
CT- and fluoroscopy-guided percutaneous screw fixation of a "carrot-stick" spinal fracture in an elderly man with ankylosing spondylitis. (23842576)
2013
12
Cardiorespiratory fitness and cardiovascular risk in patients with ankylosing spondylitis: a cross-sectional comparative study. (23281265)
2013
13
In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis. (23508523)
2013
14
Old and new HLA associations with ankylosing spondylitis. (22881057)
2012
15
Paediatric rheumatology: RCT of adalimumab supports anti-TNF therapy for juvenile-onset ankylosing spondylitis. (23147904)
2012
16
Conventional DMARD therapy (methotrexate-sulphasalazine) may decrease the requirement of biologics in routine practice of ankylosing spondylitis patients: a real-life experience. (23253235)
2012
17
Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis. (22876137)
2012
18
Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. (20952467)
2011
19
Hypoparathyroidism mimicking ankylosing spondylitis and myopathy: a case report. (21876989)
2011
20
Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response. (20722024)
2010
21
Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. (19804562)
2010
22
Severe atlantoaxial subluxation in early ankylosing spondylitis. (20921854)
2010
23
Genetic aspects of osteopenia/osteoporosis in ankylosing spondylitis]. (19938354)
2009
24
Pro-inflammatory effect of leptin on peripheral blood mononuclear cells of patients with ankylosing spondylitis. (19059800)
2009
25
IL-23R polymorphisms in patients with ankylosing spondylitis in Korea. (19369463)
2009
26
The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept. (19488017)
2009
27
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
28
Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis. (18785308)
2008
29
Male osteoporosis with vertebral fractures? Look for ankylosing spondylitis! A report of 10 cases. (17918785)
2007
30
Occlusive retinal vasculitis in a patient with ankylosing spondylitis. (15999133)
2006
31
Elevated serum levels of soluble receptor activator of nuclear factors-kappaB ligand (sRANKL) and reduced bone mineral density in patients with ankylosing spondylitis (AS). (16567356)
2006
32
Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis. (17105859)
2006
33
Study of undifferentiated spondyloarthropathy among first-degree relatives of ankylosing spondylitis probands. (15741196)
2005
34
Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism. (16386647)
2005
35
Bone turnover markers, anterior pituitary and gonadal hormones, and bone mass evaluation using quantitative computed tomography in ankylosing spondylitis. (15592691)
2005
36
Which patients with ankylosing spondylitis should be treated with tumour necrosis factor inhibiting therapy? A survey among Dutch rheumatologists. (15082483)
2004
37
Cytokine correlates of clinical response patterns to infliximab treatment of ankylosing spondylitis. (14672897)
2004
38
Efficacy of anakinra in active ankylosing spondylitis: a clinical and magnetic resonance imaging study. (15066864)
2004
39
Novel approaches in the treatment of ankylosing spondylitis and other spondyloarthritides. (12831346)
2003
40
Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for disease pathogenesis. (12746911)
2003
41
Anti-tumour necrosis factor alpha therapy for ankylosing spondylitis: international experience. (12381511)
2002
42
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in ankylosing spondylitis. (12468823)
2002
43
Interleukin 6 gene promoter polymorphism is not associated with ankylosing spondylitis. (10852271)
2000
44
Ankylosing spondylitis: time to focus on ankylosis. (10229392)
1999
45
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
46
A genome-wide screen for susceptibility loci in ankylosing spondylitis. (9550467)
1998
47
Osteomalacia and osteoporosis in a woman with ankylosing spondylitis. (9157786)
1996
48
Spinal abnormalities similar to ankylosing spondylitis in a 58-year-old woman with ochronosis. (7641516)
1995
49
IgM, IgA and IgG class serum antibodies against Klebsiella pneumoniae and Escherichia coli lipopolysaccharides in patients with ankylosing spondylitis. (7981989)
1994
50
Rapidly progressive aortic incompetence in juvenile ankylosing spondylitis: a case report. (6233987)
1984

Variations for Spondylitis

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Expression for genes affiliated with Spondylitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for genes affiliated with Spondylitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 60Thomson Reuters, 5Cell Signaling Technology, 54R&D Systems, 53QIAGEN, 57SinoBiological
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Pathways related to Spondylitis according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HLA-B, PSMB9, TAP1
29.8TAP2, TAP1, CD79A
39.6TNFSF11, PTH
49.5HLA-B, TAP1, TAP2, FCAR
5
Show member pathways
9.4TAP2, TAPBP, TAP1, HLA-B
69.3TNFSF11, CD79A, TAP2, TAP1
7
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.2CD79A, TNF, IL17A
8
Show member pathways
9.0TNFRSF1A, TNF
99.0PTH, TNFSF11, TNF
10
Show member pathways
8.8HLA-B, TAPBP, PSMB9, TAP1, TAP2, CD79A
118.8TNFRSF1A, NOD2, TNF
128.8TNF, TNFRSF1A, NOD2
138.6MMP3, TNFSF11, IL17A, TNF
148.6TNFSF11, TNFRSF1A, TNFRSF1B
15
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
8.5TNF, TNFRSF1B, TNFRSF1A
16
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.5TNFRSF1A, TNFRSF1B, TNF
178.5TNFRSF1B, TNFRSF1A, TNF
188.5TNFRSF1A, TNF, TNFRSF1B
19
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
8.5TNF, TNFRSF1A, TNFRSF1B
20
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.5TNFRSF1B, TNF, TNFRSF1A
21
Show member pathways
Alternative NF-kappaB pathway38
8.5TNFRSF1A, TNF, TNFRSF1B
22
Show member pathways
8.5TNF, TNFRSF1A, TNFRSF1B
238.5TNFRSF1B, TNFRSF1A, TNF
24
Show member pathways
8.5TNFRSF1B, TNF, TNFRSF1A
25
Show member pathways
8.5TNF, TNFRSF1B, TNFRSF1A
268.5TNFRSF1A, TNF, TNFSF11
27
Show member pathways
8.5TNFRSF1A, TNF, TNFSF11
288.5TNFSF11, TNFRSF1A, TNF
29
Show member pathways
8.4TNFRSF1A, IL17A, NOD2, TNF
30
Show member pathways
8.4HLA-B, TAP2, TAP1, TNFRSF1A, TNF
31
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.0TNFRSF1B, TNFRSF1A, TNFSF11, TNF
32
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
8.0TNF, TNFRSF1A, TNFRSF1B, TNFSF11
33
Show member pathways
8.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11
348.0TNF, TNFRSF1A, TNFSF11, TNFRSF1B
357.9TNFRSF1A, MMP3, TNFRSF1B, NOD2, TNF
36
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
7.7TAP2, TAPBP, PSMB9, HLA-B, TNF, TNFRSF1A
37
Show member pathways
7.6TNF, TNFRSF1A, TNFSF11, IL17A, TNFRSF1B
38
Show member pathways
7.4TNF, TAP2, TAPBP, TAP1, TNFRSF1A, TNFRSF1B

Compounds for genes affiliated with Spondylitis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 3BitterDB, 61Tocris Bioscience, 24HMDB
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Compounds related to Spondylitis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1lactulose4510.0CRP, NOD2, CD79A
2pamidronate45 51 1111.5CRP, TNFSF11, PTH
3deoxypyridinoline459.4CRP, MMP3, PTH, TNFSF11
4sulfasalazine29 45 51 1112.3CRP, MMP3, TNF, CD79A
5prednisolone45 29 1111.1MMP3, NOD2, CRP, CD79A, TNF
6pmma459.1CRP, CD79A, TNFSF11
7blys459.1TNF, TNFRSF1A, CD79A
8okt3458.8TNF, TNFRSF1A, CRP, CD79A
9polyethylene glycol458.8TNFRSF1B, TNFRSF1A, CRP, CD79A
10tacrolimus45 51 1110.6HLA-B, TNF, TNFSF11, NOD2, CD79A, IL17A
11prostaglandin458.6MMP3, IL17A, PTH, TNF, TNFSF11
12p003458.6CHI3L1, TNFRSF1A, HLA-B, CRP
13vitamin d458.6CD79A, PTH, MMP3, TNFSF11, TNFRSF1B
14fibrinogen458.6CD79A, CRP, HLA-B, TNF, TNFRSF1B
15adalimumab45 51 1110.6TNFRSF1A, TNF, MMP3, CRP, CD79A
16leflunomide45 51 1110.6TNF, TNFRSF1A, TNFSF11, MMP3
17chloroquine45 3 51 29 1112.5TNFRSF1A, CD79A, TNF, TNFRSF1B
18p002458.5TNFRSF1A, MMP3, TNFRSF1B, IL17A, CRP
19ns 39845 619.5TNF, TNFSF11, TNFRSF1A, IL17A
20ivig458.4TNF, CD79A, CRP, TNFRSF1B, TNFRSF1A
21neopterin458.3CD79A, CRP, TNFRSF1A, TNF, TNFRSF1B
22alanine458.2TAP1, TAP2, CD79A, TAPBP, TNFRSF1A, MMP3
23curcumin458.2IL17A, TNFRSF1A, MMP3, TNF, TNFRSF1B
24sp 60012545 619.1TNFSF11, TNF, TNFRSF1A, IL17A
25atp45 299.1TNFSF11, PTH, TAP2, TAP1, MMP3, TNFRSF1A
26n acetylcysteine458.0CRP, CD79A, TNFSF11, TNF, TNFRSF1A, MMP3
27indomethacin45 29 61 1110.9TNF, TNFRSF1A, TNFSF11, MMP3, CD79A, IL17A
28sb 20358045 618.9MMP3, CRP, IL17A, TNFSF11, TNFRSF1A, TNF
29testosterone45 61 24 1110.8TNFSF11, PTH, HLA-B, CRP, CD79A, TNFRSF1B
30endotoxin457.8IL17A, NOD2, TNFRSF1A, TNF, TNFRSF1B, HLA-B
31forskolin45 51 119.8TNFRSF1A, TNFRSF1B, TNFSF11, PTH, MMP3, IL17A
32creatinine457.7CD79A, HLA-B, TNFRSF1A, TNFSF11, PTH, MMP3
33h2o2457.7CD79A, HLA-B, TNFSF11, TNFRSF1B, TNFRSF1A, TNF
34retinoic acid45 248.5TNF, MMP3, CD79A, TAPBP, TNFRSF1A, TNFRSF1B
35rantes457.5IL17A, TNFRSF1A, TNFRSF1B, HLA-B, MMP3, TNF
36etanercept45 51 119.4TNFRSF1A, TNF, TNFSF11, MMP3, IL17A, CRP
37oxygen45 248.3TNFSF11, TNFRSF1B, TNFRSF1A, TNF, NOD2, MMP3
38estrogen457.3CHI3L1, MMP3, TNFSF11, PTH, TNFRSF1A, TNFRSF1B
39cyclosporin a45 29 619.2TNFSF11, IL17A, MMP3, CD79A, TNFRSF1B, TNF
40infliximab45 51 119.2NOD2, TNFRSF1B, TNF, TNFRSF1A, TNFSF11, MMP3
41methotrexate51 45 119.2TNF, TNFRSF1A, TNFRSF1B, TNFSF11, IL17A, CRP
42calcium45 51 24 1110.2HLA-B, TNFRSF1B, PTH, MMP3, NOD2, TAP2
43lipid457.1HLA-B, TNFRSF1B, TNFRSF1A, TNF, TNFSF11, CRP
44serine457.1TNFRSF1B, TNFRSF1A, TNFSF11, FCAR, MMP3, NOD2
45tyrosine457.1MMP3, FCAR, PTH, TNFRSF1A, TNFSF11, TNFRSF1B
46cycloheximide457.0TNFRSF1B, TNF, TNFRSF1A, TNFSF11, PTH, MMP3
47pge2456.9MMP3, HLA-B, TNFRSF1B, CD79A, TNF, TNFRSF1A
48dexamethasone45 51 29 119.9TNFRSF1A, TNFSF11, HLA-B, IL17A, PTH, MMP3
49nitric oxide45 24 118.8PTH, TNFRSF1B, IL17A, TNF, CHI3L1, TNFRSF1A
50vegf456.8TNFSF11, PTH, MMP3, IL17A, CRP, CD79A

GO Terms for genes affiliated with Spondylitis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Spondylitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:0428259.8TAP2, TAPBP, TAP1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.8TAPBP, HLA-B
3external side of plasma membraneGO:0098978.9CD79A, IL17A, TNF
4cell surfaceGO:0099868.6HLA-B, TNF, TNFRSF1A, NOD2
5membrane raftGO:0451218.4TNFRSF1B, TNF, TNFRSF1A, CD79A
6integral component of plasma membraneGO:0058877.9HLA-B, TNF, TNFRSF1A, TNFSF11, FCAR
7extracellular regionGO:0055767.5TNFRSF1B, TNFRSF1A, TNFSF11, PTH, FCAR, MMP3
8plasma membraneGO:0058867.1HLA-B, TNFRSF1B, TNF, TNFRSF1A, FCAR, TAP1
9extracellular spaceGO:0056156.9TNF, TNFRSF1A, TNFSF11, PTH, MMP3, CHI3L1

Biological processes related to Spondylitis according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.4TAP2, TAP1
2oligopeptide transmembrane transportGO:03567210.4TAP1, TAP2
3intracellular transport of viral protein in host cellGO:01906010.3TAP1, TAP2
4positive regulation of T cell mediated cytotoxicityGO:00191610.2TAP2, TAP1, HLA-B
5detection of bacteriumGO:01604510.2HLA-B, NOD2
6defense responseGO:00695210.1TAP1, NOD2, HLA-B
7response to lead ionGO:01028810.0PTH, CRP
8antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.0TAP2, TAPBP, TAP1
9peptide transportGO:01583310.0TAP2, TAPBP, TAP1
10positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.9TNF, NOD2
11negative regulation of lipid storageGO:0108889.8TNF, CRP
12negative regulation of growth of symbiont in hostGO:0441309.7TNF, NOD2
13bone resorptionGO:0454539.7PTH, TNFSF11
14defense response to Gram-positive bacteriumGO:0508309.7CRP, NOD2, TNF
15positive regulation of membrane protein ectodomain proteolysisGO:0510449.6TNF, TNFRSF1B
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.5TAPBP, TAP1, PSMB9, TAP2, HLA-B
17antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.5TAPBP, TAP2, TAP1, HLA-B, PSMB9
18antigen processing and presentation of peptide antigen via MHC class IGO:0024749.5HLA-B, PSMB9, TAP1, TAPBP, TAP2
19positive regulation of ERK1 and ERK2 cascadeGO:0703749.4NOD2, CHI3L1, TNF
20positive regulation of JNK cascadeGO:0463309.4NOD2, TNFSF11, TNF
21tumor necrosis factor-mediated signaling pathwayGO:0332099.3TNFSF11, TNF
22positive regulation of osteoclast differentiationGO:0456729.3TNF, TNFSF11, IL17A
23positive regulation of NF-kappaB transcription factor activityGO:0510929.3TNFSF11, NOD2, TNF
24response to ethanolGO:0454719.3TNFRSF1A, PTH, CRP
25positive regulation of protein kinase B signalingGO:0518979.2CHI3L1, TNFSF11, TNF
26osteoclast differentiationGO:0303169.0TNF, TNFSF11
27negative regulation of interleukin-6 productionGO:0327158.9TNF, TNFRSF1A
28intrinsic apoptotic signaling pathway in response to DNA damageGO:0086308.8TNFRSF1B, TNFRSF1A, TNF
29response to hypoxiaGO:0016668.7TNFRSF1A, CRP, TNF
30positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.6NOD2, TNFSF11, TNFRSF1A, TNF
31immune responseGO:0069558.5HLA-B, TNFSF11, FCAR, IL17A, TAPBP, TNFRSF1B
32positive regulation of transcription from RNA polymerase II promoterGO:0459447.9TNF, TNFSF11, PTH, TNFRSF1A, IL17A, NOD2
33inflammatory responseGO:0069547.8TNFRSF1A, TNFRSF1B, CHI3L1, IL17A, CRP, TNF

Molecular functions related to Spondylitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.2TAP1, TAP2
2MHC class Ib protein bindingGO:02302910.2TAP1, TAP2
3peptide transporter activityGO:01519710.1TAP1, TAP2
4oligopeptide-transporting ATPase activityGO:01542110.0TAP2, TAP1
5peptide antigen-transporting ATPase activityGO:01543310.0TAP2, TAPBP
6TAP2 bindingGO:0469799.8TAP1, TAPBP, TAP2
7TAP1 bindingGO:0469789.8TAP1, TAPBP, TAP2
8MHC class I protein bindingGO:0422889.8TAP1, TAPBP, TAP2
9peptide antigen bindingGO:0426059.6TAP2, TAPBP, TAP1, HLA-B
10tumor necrosis factor receptor bindingGO:0051649.3TNFSF11, TNF
11tumor necrosis factor-activated receptor activityGO:0050319.0TNFRSF1B, TNFRSF1A
12cytokine activityGO:0051258.7IL17A, TNFSF11, TNF

Products for genes affiliated with Spondylitis

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Sources for Spondylitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet