MCID: SPN051
MIFTS: 60

Spondylitis malady

Summaries for Spondylitis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

MalaCards: Spondylitis is related to ankylosing spondylitis and arthritis. An important gene associated with Spondylitis is TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Immune System and CDK-mediated phosphorylation and removal of Cdc6. The compounds vegf and infliximab have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and endothelial, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Spondylitis

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
See all sources

Aliases & Descriptions:

spondylitis 8 44 60


External Ids:

Disease Ontology8 DOID:6590
ICD9CM27 720.8, 720.89

Related Diseases for Spondylitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spondylitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 377)
idRelated DiseaseScoreTop Affiliating Genes
1ankylosing spondylitis32.0PTH, NOD2, FCAR, MMP3, TAP2, TAPBP
2arthritis31.2MMP3, IL17A, TNF, TNFSF11, TNFRSF1A
3rheumatoid arthritis31.0NOD2, MMP3, TAP2, IL17A, IL1RN, CD79A
4psoriatic arthritis30.8NOD2, MMP3, CRP, TNF, TNFSF11, TNFRSF1A
5uveitis30.8NOD2, IL17A, HLA-B, TNF, TNFRSF1A, TNFRSF1B
6reactive arthritis30.6TAP2, CD79A, PRTN3, CRP, HLA-B
7crohn's disease30.4NOD2, CRP, TNF, TNFRSF1B
8amyloidosis30.4CD79A, CRP, HLA-B, TNFRSF1A
9psoriasis30.4NOD2, TAP2, TAP1, IL17A, HLA-B, TNF
10pneumonia30.4IL17A, CD79A, CRP, TNF, TNFRSF1B, TLR4
11inflammatory bowel disease30.3NOD2, MMP3, IL17A, IL1RN, PRTN3, CRP
12tuberculosis30.3NOD2, IL17A, CD79A, CRP, TNF, TNFRSF1A
13atherosclerosis30.3NOD2, MMP3, IL17A, IL1RN, CD40LG, PRTN3
14vasculitis30.3IL17A, CD79A, CD40LG, PRTN3, CRP, HLA-B
15glomerulonephritis30.2IL1RN, CD79A, CD40LG, PRTN3
16osteoporosis30.2PTH, MMP3, IL1RN, TNFSF11
17myositis30.2IL1RN, HLA-B, TNFRSF1B
18connective tissue disease30.1CD79A, CD40LG, PRTN3, TNF
19mixed connective tissue disease30.1PRTN3, TNFRSF1B
20familial mediterranean fever30.1TNF, TNFRSF1A
21epidural abscess30.1CRP
22systemic lupus erythematosus30.0NOD2, MMP3, TAP2, TAP1, IL17A, IL1RN
23ulcerative colitis30.0NOD2, MMP3, IL17A, IL1RN, CD79A, PRTN3
24osteoarthritis30.0MMP3, IL17A, IL1RN, CRP, TNF, TNFSF11
25arthropathy30.0NOD2, MMP3, IL1RN, CRP, TNF, TNFSF11
26sarcoidosis30.0NOD2, TAP2, TAP1, IL1RN, TNF, TNFRSF1B
27vascular disease30.0MMP3, IL1RN, TNF, TNFRSF1A
28lupus erythematosus30.0CD79A, CD40LG
29polymyalgia rheumatica30.0IL1RN, CRP
30aortic aneurysm30.0CRP
31leukemia29.9TAP2, TAP1, IL17A, CD79A, CD40LG, PRTN3
32multiple sclerosis29.9TAP2, TAP1, IL17A, IL1RN, HLA-B, TNF
33dermatitis29.9NOD2, IL17A, CD79A, TNFRSF1B
34meningitis29.9CD79A, CRP, HLA-B
35iga glomerulonephritis29.9FCAR, CD79A, CD40LG, PRTN3
36abdominal aortic aneurysm29.9MMP3, TNFRSF1A, TNFRSF1B
37thyroiditis29.9CD79A
38purpura29.9CD79A
39neuropathy29.9CD79A
40myeloid leukemia29.9PRTN3, TLR4
41endocarditis29.9PRTN3
42leishmaniasis29.9TNFRSF1A
43synovitis29.7MMP3, IL17A, IL1RN, CRP, TNF, TNFSF11
44myeloma29.7CD79A, CD40LG, HLA-B, TNFSF11, TNFRSF1A, TNFRSF1B
45periodontitis29.7MMP3, IL17A, IL1RN, TNF, TNFSF11, TLR4
46squamous cell carcinoma29.7MMP3, TAP2, TAPBP, TAP1, PRTN3, HLA-B
47hodgkin's lymphoma29.7IL1RN, HLA-B, PSMB9, TNFRSF1A, TNFRSF1B
48neutropenia29.7IL1RN, PRTN3, TNFRSF1A, TNFRSF1B
49coronary artery disease29.7MMP3, IL17A, CRP, TNFSF11, TNFRSF1B
50proteinuria29.7CD79A, CD40LG, PRTN3, CRP

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to spondylitis

Clinical Features for Spondylitis

About this section

Drugs & Therapeutics for Spondylitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spondylitis

Drug clinical trials:

Search ClinicalTrials for Spondylitis

Search NIH Clinical Center for Spondylitis

Search CenterWatch for Spondylitis

Genetic Tests for Spondylitis

About this section

Anatomical Context for Spondylitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Spondylitis:

32
Bone, T cells, Endothelial, Testes, Eye, Whole blood, Heart, Myeloid, Monocytes, Bone marrow, Skin, Pituitary, Thyroid, Liver, Colon, Brain, B cells, Spinal cord, Nk cells, Lung, Breast

Animal Models for Spondylitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Spondylitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.2PTH, CRP, HLA-B, PSMB9, TNF, TNFSF11
2MP:000539711.9HLA-B, PSMB9, TNF, TNFSF11, TNFRSF1A, TNFRSF1B
3MP:000538411.6TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, TNF, HLA-B
4MP:000537611.5TNF, TNFSF11, TNFRSF1A, TNFRSF1B, TLR4, CRP
5MP:001076811.4TNF, TNFSF11, TNFRSF1A, TNFRSF1B, TLR4, HLA-B
6MP:000538511.1TNFRSF1B, TNFRSF1A, TNF, CRP, CD40LG, IL1RN
7MP:000539011.1TNFRSF1B, TNFRSF1A, TNFSF11, CD40LG, MMP3, NOD2
8MP:001077110.8TLR4, TNFRSF1B, TNFSF11, CD40LG, TAP1
9MP:000200610.5TNFRSF1B, TNFRSF1A, TNF, TAP1

Publications for Spondylitis

About this section
Sources:
50PubMed
See all sources

Articles related to Spondylitis:

(show top 50)    (show all 1301)
idTitleAuthorsYear
1
A Comparison of the GlideScope With the Macintosh Laryngoscope for Nasotracheal Intubation in Patients With Ankylosing Spondylitis. (23764717)
2014
2
The association between varicocele and ankylosing spondylitis via color duplex sonography. (24261773)
2014
3
Safe Re-administration of Tumor Necrosis Factor-alpha (TNFI+) Inhibitors in Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Who Developed Active Tuberculosis on Previous Anti-TNFI+ Therapy. (24431903)
2014
4
Adalimumab for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis - a five-year update. (24074224)
2013
5
The permanent improvement of proteinuria and renal failure with colchicine and enalapril in a leukemic patient with renal amyloidosis secondary to ankylosing spondylitis: a review of the literature. (22975660)
2013
6
Spinal mobility, vertebral squaring, pulmonary function, pain, fatigue, and quality of life in patients with ankylosing spondylitis. (24236255)
2013
7
Patellar tendon properties and lower limb function in rheumatoid arthritis and ankylosing spondylitis versus healthy controls: a cross-sectional study. (23844402)
2013
8
Is the work ability index useful to evaluate absence days in ankylosing spondylitis patients? A cross-sectional study. (23524041)
2013
9
Pregabalin for opioid-refractory pain in a patient with ankylosing spondylitis. (23844301)
2013
10
Ankylosing spondylitis: from cells to genes. (23970995)
2013
11
Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals. (24046467)
2013
12
Intestinal BehAset's disease appearing during treatment with adalimumab in a patient with ankylosing spondylitis. (23983446)
2013
13
Fatigue in ankylosing spondylitis: treatment should focus on pain management. (22901458)
2013
14
ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role. (23656713)
2013
15
Real-time sonoelastography of Achilles tendon in patients with ankylosing spondylitis. (23685710)
2013
16
Association between ankylosing spondylitis and chronic periodontitis: a population-based study. (23055204)
2013
17
Juvenile versus adult-onset ankylosing spondylitis -- clinical, radiographic, and social outcomes. a systematic review. (24037547)
2013
18
Painless engorgement of the calf in a patient with ankylosing spondylitis. (24341970)
2013
19
Serum levels of novel noggin and sclerostin-immune complexes are elevated in ankylosing spondylitis. (23894062)
2013
20
Cauda equina syndrome in ankylosing spondylitis. (23519172)
2013
21
The effect of two golimumab doses on radiographic progression in ankylosing spondylitis: results through 4 years of the GO-RAISE trial. (23644549)
2013
22
Ankylosing spondylitis - the changing role of imaging. (22722310)
2012
23
A patient with ankylosing spondylitis who developed infliximab-induced lupus and treated with etanercept. (23263496)
2012
24
Management of pregnancy with ankylosing spondylitis. (22734214)
2012
25
Radiographic severity of ankylosing spondylitis is associated with polymorphism of the large multifunctional peptidase 2 gene in the Spondyloarthritis Research Consortium of Canada cohort. (22034108)
2012
26
Anaplastic large cell lymphoma of the vertebra masquerading as tuberculous spondylitis: potential pitfalls of conventional imaging. (23054413)
2012
27
Ankylosing spondylitis accompanying with Hodgkin's lymphoma. (22898229)
2012
28
Splenic tuberculosis in a patient with ankylosing spondylitis treated with adalimumab. (22257918)
2011
29
The management of spinal injuries in patients with ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis: a comparison of treatment methods and clinical outcomes. (19342927)
2009
30
Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis. (19247658)
2009
31
Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis. (19877087)
2009
32
Association of the MSX2 gene polymorphisms with ankylosing spondylitis in Japanese. (18299954)
2008
33
Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis. (18720263)
2008
34
The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis. (18199597)
2008
35
Trend towards increased arterial stiffness or intima-media thickness in ankylosing spondylitis patients without clinically evident cardiovascular disease. (18524805)
2008
36
Occlusive retinal vasculitis in a patient with ankylosing spondylitis. (15999133)
2006
37
Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis. (17105859)
2006
38
Ochronotic spondyloarthropathy: spinal involvement resembling ankylosing spondylitis. (16267610)
2006
39
Myositis ossificans progressiva mimicking ankylosing spondylitis (a case report). (16546430)
2006
40
HLA-B*2704, an allotype associated with ankylosing spondylitis, is critically dependent on transporter associated with antigen processing and relatively independent of tapasin and immunoproteasome for maturation, surface expression, and T cell recognition: relationship to B*2705 and B*2706. (17082617)
2006
41
Susceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor beta 1 (TGFB1) gene polymorphisms. (15769917)
2005
42
Retroperitoneal fibrosis and ankylosing spondylitis: which links? (16084223)
2005
43
Pathogenesis of ankylosing spondylitis and reactive arthritis. (15956835)
2005
44
Hypothalamic-pituitary-adrenal axis function in ankylosing spondylitis. (15140773)
2004
45
Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. (14677189)
2003
46
Cellular immune response to Klebsiella pneumoniae antigens in patients with HLA-B27+ ankylosing spondylitis. (10852270)
2000
47
Ankylosing spondylitis: time to focus on ankylosis. (10229392)
1999
48
Frequency of atlantoaxial subluxation and neurologic involvement in patients with ankylosing spondylitis. (8596154)
1995
49
Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis. (1352961)
1992
50
Ankylosing spondylitis with subsequent development of rheumatoid arthritis, SjAPgren's syndrome, and rheumatoid vasculitis. (646836)
1978

Genetic Variations for Spondylitis

About this section

Expression for genes affiliated with Spondylitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for genes affiliated with Spondylitis

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 55SinoBiological, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Spondylitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2TLR4, PSMB9, HLA-B, CD40LG, CD79A, IL1RN
2
Hide members
11.0TNFRSF1A, TNF, PSMB9, HLA-B, TAP1, TAPBP
3
Hide members
11.0TLR4, TNFRSF1A, TNF, HLA-B, TAP1, TAP2
4
Hide members
11.0TLR4, TNFRSF1A, TNF, CD40LG, IL17A, NOD2
5
Hide members
10.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, TNF, CD40LG
610.9PSMB9, HLA-B, TAP1, TAPBP, TAP2
7
Hide members
10.9PSMB9, HLA-B, TAP1, TAPBP, TAP2
810.9FCAR, TAP2, TAP1, HLA-B, TLR4
910.9TNFRSF1B, TNFRSF1A, TNF, MMP3, NOD2
10
Hide members
10.9TNFRSF1B, TNFRSF1A, TNF, HLA-B, CD40LG
11
Hide members
10.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, IL17A
12
Hide members
10.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, TNF
1310.9TLR4, TNFRSF1B, TNFRSF1A, TNFSF11, TNF
14
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
10.9CD40LG, TNF, TNFSF11, TNFRSF1A, TNFRSF1B
1510.9TLR4, TNFRSF1A, TNFSF11, TNF, CD40LG
16
Hide members
10.8HLA-B, TAP1, TAPBP, TAP2
1710.8TAP2, TAP1, CD79A, TNFSF11
1810.8TLR4, TNFRSF1A, TNF, NOD2
19
Hide members
10.8TNFRSF1B, TNFRSF1A, TNFSF11, TNF
2010.8TLR4, TNFRSF1B, TNFRSF1A, TNF
21
Hide members
10.8TLR4, TNFRSF1B, TNFRSF1A, TNF
2210.7PSMB9, HLA-B, TAP1
23
Hide members
10.7TAP1, TAPBP, TAP2
24
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.7CRP, IL1RN, TAP1
2510.7TNFRSF1A, TNF, NOD2
26
Hide members
10.7IL17A, CD79A, CD40LG
27
Hide members
10.7IL17A, TNF, TLR4
28
Hide members
10.7TNF, TNFRSF1A, TNFRSF1B
2910.7TNF, TNFRSF1A, TNFRSF1B
30
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.7TNFRSF1B, TNFRSF1A, TNF
3110.7TNF, TNFRSF1A, TNFRSF1B
32
Hide members
10.7TNFRSF1B, TNFRSF1A, TNF
3310.7TNF, TNFRSF1A, TNFRSF1B
34
Hide members
10.7TNFRSF1B, TNFRSF1A, TNF
35
Immune response Bacterial infections in normal airways
Hide members
10.7IL1RN, TNF, TLR4
3610.7CD40LG, TNFRSF1A, TNFRSF1B
3710.6TAP1, CD79A
38
Hide members
10.6TNF, TNFRSF1A
39
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.6TNFSF11, PTH
4010.6TNFSF11, TLR4
4110.6TLR4

Compounds for genes affiliated with Spondylitis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Spondylitis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1vegf4411.9CD40LG, IL17A, IL1RN, TLR4, PTH, TNFRSF1B
2infliximab44 49 1113.8TLR4, IL17A, MMP3, NOD2, TNFRSF1B, TNFRSF1A
3alanine4411.8CRP, MMP3, IL1RN, CD40LG, CD79A, TNFRSF1A
4retinoic acid44 2412.7CD40LG, CD79A, TLR4, IL1RN, TAPBP, PRTN3
5lipid4411.7HLA-B, TNF, TNFRSF1A, TLR4, TNFRSF1B, CRP
6nitric oxide44 11 2413.7IL1RN, NOD2, PTH, HLA-B, TNFRSF1A, IL17A
7serine4411.6TLR4, NOD2, MMP3, TNF, IL1RN, PRTN3
8methotrexate44 49 1113.6IL17A, MMP3, TNF, IL1RN, CD79A, TNFRSF1B
9creatinine4411.6MMP3, CRP, TNFSF11, TNFRSF1A, CD79A, IL1RN
10etanercept44 49 1113.6TNF, TNFSF11, TNFRSF1A, TNFRSF1B, CRP, IL1RN
11testosterone44 59 11 2414.5HLA-B, PTH, IL1RN, CD79A, CD40LG, TNFRSF1B
12n acetylcysteine4411.5CD40LG, TNFSF11, CRP, CD79A, TNF, MMP3
13sb 20358044 5912.5MMP3, TNF, TLR4, TNFRSF1A, TNFSF11, CRP
14fibrinogen4411.5TNF, IL1RN, CD79A, CD40LG, TNFRSF1B, HLA-B
15ivig4411.5CD79A, CD40LG, IL1RN, CRP, TNF, TNFRSF1A
16neopterin4411.5IL1RN, CD79A, CRP, TNF, TNFRSF1A, TNFRSF1B
17p0024411.4MMP3, TNFRSF1B, IL17A, IL1RN, PRTN3, CRP
18calcium44 49 11 2414.4CRP, PTH, NOD2, TLR4, IL1RN, TAP2
19lactate4411.4MMP3, CD40LG, CD79A, TLR4, CRP, TNF
20rantes4411.4TLR4, TNF, HLA-B, CD40LG, IL17A, TNFRSF1A
21cyclosporin a44 28 5913.4CD40LG, TNFRSF1B, IL17A, CD79A, HLA-B, TNFSF11
22dexamethasone44 49 28 1114.4TNFRSF1B, TLR4, PTH, TNFSF11, CD40LG, CD79A
23sulfasalazine44 28 49 1114.4MMP3, CD79A, TNF, CD40LG, CRP, IL1RN
24chloroquine44 2 49 28 1115.3IL1RN, CD79A, TNF, TNFRSF1B, TLR4, TNFRSF1A
25polyethylene glycol4411.3TNFRSF1B, CRP, CD40LG, CD79A, IL1RN, TNFRSF1A
26oxygen44 2412.3PRTN3, FCAR, TNF, TNFRSF1B, TNFRSF1A, TNFSF11
27adalimumab44 49 1113.3TNF, CRP, CD79A, IL1RN, MMP3
28leflunomide49 44 1113.3TNF, TNFSF11, TNFRSF1A, MMP3, IL1RN
29tyrosine4411.2HLA-B, TNFSF11, TNFRSF1A, PTH, FCAR, MMP3
30okt34411.2TNFRSF1A, TNF, CD79A, CRP, CD40LG
31ns 39844 5912.2TNFRSF1A, TNFSF11, IL17A, TNF, IL1RN
32vitamin d4411.2TNFRSF1B, TNFSF11, CD79A, MMP3, TLR4, PTH
33simvastatin44 49 59 28 11 2416.2CRP, IL1RN, TNFRSF1A, MMP3, TNF, TLR4
34mannose4411.2TLR4, NOD2, CD79A, FCAR, IL17A, IL1RN
35il 104411.2NOD2, TNF, TNFRSF1B, IL1RN, TLR4
36peptidoglycan44 2812.1TLR4, NOD2, TNFSF11, TNF, IL1RN
37prednisolone44 28 1113.1CRP, CD79A, MMP3, NOD2
38pneumococcal4411.1TLR4, HLA-B, CD40LG, CD79A
39prostaglandin4411.1MMP3, IL17A, TNFSF11, TNF, IL1RN, PTH
40superoxide44 2412.1TNFRSF1B, TNF, FCAR, TNFRSF1A
41blys4411.1TNFRSF1A, TNF, CD40LG, CD79A
42endotoxin4411.1TNFRSF1B, TNFRSF1A
43rituximab44 49 1113.1TNF, CD79A, CD40LG, PRTN3, CRP
44estrogen4411.0TNFRSF1B, CD79A, PRTN3
45cycloheximide4411.0PTH
46fmlp4410.9TNFRSF1B, PRTN3, IL1RN
47h2o24410.9TNFRSF1B, TNFRSF1A, CD79A, IL1RN
48tacrolimus44 49 1112.8IL17A, TNFSF11, CD79A
49pmma4410.8CD79A, CD40LG, TNFSF11, CRP
50forskolin44 49 1112.3TAP2, PTH

GO Terms for genes affiliated with Spondylitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Spondylitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.7CRP, HLA-B, TNF, TNFRSF1A, TNFRSF1B, TLR4
2extracellular spaceGO:00561511.3PTH, TNFRSF1A, TNFSF11, TNF, CRP, CD40LG
3integral to plasma membraneGO:00588711.0TNFRSF1A, TNFSF11, TNF, HLA-B, CD40LG, FCAR
4external side of plasma membraneGO:00989710.9IL17A, CD79A, CD40LG, TNF, TLR4
5extracellular regionGO:00557610.8TNFRSF1B, TNFRSF1A, TNFSF11, TNF, CRP, MMP3
6TAP complexGO:04282510.8TAP1, TAPBP, TAP2
7membrane raftGO:04512110.7TNFRSF1B, TNFRSF1A, TNF, CD79A

Biological processes related to Spondylitis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.5FCAR, TLR4, TNFRSF1B, TNFSF11, HLA-B, IL1RN
2inflammatory responseGO:00695411.3TNFRSF1B, TNFRSF1A, TNF, CRP, CD40LG, IL17A
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247911.3PSMB9, HLA-B, TAP1, TAPBP, TAP2
4antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259011.3PSMB9, HLA-B, TAP1, TAPBP, TAP2
5antigen processing and presentation of peptide antigen via MHC class IGO:00247411.3TAP2, TAPBP, TAP1, HLA-B, PSMB9
6positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312311.2TLR4, TNFRSF1A, TNFSF11, TNF, NOD2
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.2TLR4, TNFRSF1A, TNFSF11, TNF, IL17A, PTH
8positive regulation of JNK cascadeGO:04633011.2NOD2, TNF, TNFSF11, TLR4
9defense responseGO:00695211.1HLA-B, TAP1, TAPBP, NOD2
10positive regulation of NF-kappaB transcription factor activityGO:05109211.1NOD2, TNF, TNFSF11, TLR4
11antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988511.1TAP1, TAPBP, TAP2
12positive regulation of osteoclast differentiationGO:04567211.1IL17A, TNF, TNFSF11
13positive regulation of T cell mediated cytotoxicityGO:00191611.0TAP2, TAP1, HLA-B
14negative regulation of interleukin-6 productionGO:03271511.0TLR4, TNFRSF1A, TNF
15positive regulation of interleukin-12 productionGO:03273511.0TLR4, CD40LG, NOD2
16positive regulation of tumor necrosis factor productionGO:03276011.0NOD2, TNFRSF1A, TLR4
17defense response to Gram-positive bacteriumGO:05083011.0TNF, CRP, NOD2
18positive regulation of interleukin-6 productionGO:03275511.0NOD2, TNF, TLR4
19cytosol to ER transportGO:04696710.9TAP1, TAP2
20chronic inflammatory response to antigenic stimulusGO:00243910.9TNF, IL1RN
21regulation of immunoglobulin secretionGO:05102310.8TNF, CD40LG
22intracellular transport of viral proteins in host cellGO:01906010.8TAP1, TAP2
23positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8NOD2, TNF
24peptide transportGO:01583310.8TAP2, TAP1
25activation of MAPK activityGO:00018710.7NOD2, TNF, TLR4
26negative regulation of lipid storageGO:01088810.7TNF, CRP
27positive regulation of interleukin-8 biosynthetic processGO:04541610.6TNF, TLR4
28positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.5NOD2, TLR4
29B cell proliferationGO:04210010.3CD40LG, CD79A

Molecular functions related to Spondylitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:04260511.0HLA-B, TAP1, TAPBP, TAP2
2TAP1 bindingGO:04697811.0TAP2, TAPBP, TAP1
3TAP2 bindingGO:04697910.9TAP2, TAPBP, TAP1
4MHC class I protein bindingGO:04228810.9TAP2, TAPBP, TAP1
5tumor necrosis factor receptor bindingGO:00516410.9TNFSF11, TNF, CD40LG
6peptide antigen-transporting ATPase activityGO:01543310.8TAP2, TAPBP
7peptide transporter activityGO:01519710.7TAP2, TAP1
8tapasin bindingGO:04698010.6TAP2, TAP1
9tumor necrosis factor-activated receptor activityGO:00503110.6TNFRSF1A, TNFRSF1B
10oligopeptide-transporting ATPase activityGO:01542110.5TAP1, TAP2
11cytokine activityGO:00512510.5IL17A, CD40LG, TNF, TNFSF11

Products for genes affiliated with Spondylitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet