MCID: SPN019
MIFTS: 45

Spondylolisthesis malady

Summaries for Spondylolisthesis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Spondylolisthesis is the forward displacement of a vertebra, especially the fifth lumbar vertebra, most... more...

MalaCards: Spondylolisthesis is related to spondylolysis and spinal stenosis. An important gene associated with Spondylolisthesis is BMP7 (bone morphogenetic protein 7), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and TGF-beta Signaling Pathway. The compounds carboxymethylcellulose and safranin o have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae and bone, and related mouse phenotype skeleton.

Disease Ontology:8 A bone structure disease that has material basis in displacement located in set of vertebrae.

Description from OMIM:46 184200

Aliases & Classifications for Spondylolisthesis

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 46OMIM, 34MeSH, 39NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

spondylolisthesis 8 10 44 30 60


External Ids:

Disease Ontology8 DOID:6682
OMIM46 184200
MeSH34 D013168
NCIt39 C35033
ICD1025 M43.1

Related Diseases for Spondylolisthesis

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17GeneCards, 18GeneDecks
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Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolysis31.4BMP7
2spinal stenosis30.9TSSK4, LSS, BMP7
3spondylosis30.4TSSK4
4degenerative disc disease30.3BMP2
5radiculopathy30.2KLK8, BMP2
6osteoarthritis30.2PTGS2, BMP2, GDF5, MMP3, BMP7
7cerebral palsy29.8AMIGO2
8cervicitis10.5
9spina bifida10.2
10neurofibromatosis10.2
11discitis10.2
12cauda equina syndrome10.2
13osteoporotic fracture10.1
14osteogenesis imperfecta10.1
15obesity10.1
16stroke, ischemic10.0BMP7
17galactosemia10.0FTH1
18parkinson's disease10.0GDF5
19synostosis10.0NCOA1
20sarcoma10.0BMP2
21smooth muscle tumor10.0ESR1
22osteonecrosis10.0BMP2
23trigeminal neuralgia10.0BMP2, PGRMC1
24lumbar disc disease10.0BMP2
25leiomyoma10.0ESR1, MMP3
26progressive osseous heteroplasia10.0BMP7, BMP2
27arthropathy10.0MMP3, BMP7, BMP2
28chondrosarcoma10.0MMP3, BMP2, BMP7
29adenoma10.0PTGS2
30diabetes mellitus10.0MMP3, FTH1, BMP2, BMP7
31osteosarcoma10.0ESR1, BMP2, BMP7
32osteoporosis10.0ESR1, MMP3, BMP2, BMP7
33rheumatoid arthritis10.0MMP3, BMP7, BMP2, PTGS2
34ovarian cancer10.0KLK8, BMP7, BMP2, NCOA1, ESR1
35atherosclerosis10.0LSS, MMP3, BMP2, PTGS2
36arthritis10.0MMP3, BMP7, BMP2, FTH1, GDF5, PTGS2
37adenocarcinoma10.0BMP2, NCOA1, PTGS2, ESR1, KLK8
38breast cancer9.9PTGS2, BMP2, BMP7, NCOA1, MATK, FTH1
39pseudoarthrosis9.9
40gout9.9
41rubinstein-taybi syndrome9.9
42cerebritis9.9
43nevoid basal cell carcinoma syndrome9.9
44pycnodysostosis9.9
45basal cell carcinoma9.9
46ehlers-danlos syndrome9.9
47osteomyelitis9.9
48sarcoidosis9.9
49tuberculosis9.9
50jaffer beighton syndrome9.9

Graphical network of the top 20 diseases related to Spondylolisthesis:



Diseases related to spondylolisthesis

Clinical Features for Spondylolisthesis

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46OMIM
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Clinical features from OMIM:

184200

Drugs & Therapeutics for Spondylolisthesis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spondylolisthesis

Drug clinical trials:

Search ClinicalTrials for Spondylolisthesis

Search NIH Clinical Center for Spondylolisthesis

Search CenterWatch for Spondylolisthesis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spondylolisthesis

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Anatomical Context for Spondylolisthesis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Spondylolisthesis:

32
Bone

FMA organs/tissues related to Spondylolisthesis:

14
Set of vertebrae

Animal Models for Spondylolisthesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spondylolisthesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5ESR1, PTGS2, MMP3, GDF5, NCOA1, BMP2

Publications for Spondylolisthesis

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50PubMed
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Articles related to Spondylolisthesis:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Prevalence and risk factors of lumbar spondylolisthesis in elderly Chinese men and women. (24126641)
2014
2
Radiologic evaluation of degeneration in isthmic and degenerative spondylolisthesis. (23508359)
2013
3
Intraoperative conjoined lumbosacral nerve roots associated with spondylolisthesis. (23412326)
2013
4
Surgically Treated Cases of Lumbar Spondylolysis and Isthmic Spondylolisthesis: A Multicenter Study. (23222096)
2013
5
What is the optimum fusion technique for adult isthmic spondylolisthesis--PLIF or PLF? A long-term prospective cohort comparison study. (22158302)
2013
6
Symptomatic adjacent segment pathology after posterior lumbar interbody fusion for adult low-grade isthmic spondylolisthesis. (24436872)
2013
7
Surgical treatment of high-grade dysplastic spondylolisthesis using intraoperative electrophysiological monitoring: report of two cases and review of the literature. (23463499)
2013
8
The natural history of degenerative spondylolisthesis of the cervical spine with 2- to 7-year follow-up. (23169076)
2013
9
Economic study: a cost-effectiveness analysis of an intraoperative compared with a preoperative image-guided system in lumbar pedicle screw fixation in patients with degenerative spondylolisthesis. (24184651)
2013
10
Determining optimal c2 pedicle screw placement and length in patients with axis traumatic spondylolisthesis: a case series. (24436853)
2013
11
Minimum 10-Year Follow-up Study of Anterior Lumbar Interbody Fusion for Degenerative Spondylolisthesis: Progressive Pattern of the Adjacent Disc Degeneration. (22708014)
2012
12
Operative management of a non-traumatic cervico-thoracic spondylolisthesis: a case report. (22686409)
2012
13
Spontaneous reduction of spondylolisthesis during growth: a case report. (21494159)
2012
14
Radiofrequency neurotomy for treatment of low back pain in patients with minor degenerative spondylolisthesis. (22270750)
2012
15
Posterolateral versus posterior interbody fusion in isthmic spondylolisthesis. (22260338)
2012
16
A modified technique for dowel fibular strut graft placement and circumferential fusion in the setting of L5-S1 spondylolisthesis and multilevel degenerative disc disease. (20679943)
2010
17
Back pain, neurogenic symptoms, and physical function in relation to spondylolisthesis among elderly men. (20869000)
2010
18
Treatment of isthmic spondylolisthesis: still controversial. (20920927)
2010
19
Contemporary management of isthmic spondylolisthesis: pediatric and adult. (20381432)
2010
20
Predictive factors for the outcome of fusion in adult isthmic spondylolisthesis. (19444068)
2009
21
Synovial cysts of the lumbar facet joints: a retrospective magnetic resonance imaging study investigating their relation with degenerative spondylolisthesis. (20059882)
2009
22
Adult isthmic spondylolisthesis. (19794218)
2009
23
Progression of spondylolysis to isthmic spondylolisthesis in an adult without accompanying disc degeneration: a case report. (18411618)
2008
24
Union versus nonunion after posterolateral lumbar fusion: a comparison of long-term surgical outcomes in patients with degenerative lumbar spondylolisthesis. (18536941)
2008
25
Spine patient outcomes research trial: radiographic predictors of clinical outcomes after operative or nonoperative treatment of degenerative spondylolisthesis. (19050582)
2008
26
The efficacy of local built Khon Kaen Mobile Traction Unit (KK-MTU) to assist decompression, reduction and fixation in a spondylolisthesis operation. (18672635)
2008
27
Is surgery more effective than nonsurgical treatment for the management of patients with degenerative spondylolisthesis? (18091730)
2008
28
Microsurgical bilateral decompression via a unilateral approach for lumbar spinal canal stenosis including degenerative spondylolisthesis. (19035747)
2008
29
Degenerative lumbar spondylolisthesis: trends in management. (18390483)
2008
30
Answer to the comment by Dietrich Schlenzka on ''A proposal for a surgical classification of pediatric lumbosacral spondylolisthesis based on current literature (J.-M. Mac-Thiong, H. Labelle)''. (17520302)
2007
31
Comparison of anterior- and posterior-approach instrumented lumbar interbody fusion for spondylolisthesis. (17633483)
2007
32
The radiographic results and neurologic complications of instrumented reduction and fusion of high-grade spondylolisthesis without decompression of the neural elements: a retrospective review of 44 patients. (16418634)
2006
33
Double-segment Wilhelm Tell technique for anterior lumbar interbody fusion in unstable isthmic spondylolisthesis and adjacent segment discopathy. (16459090)
2006
34
Nerve root decompression without fusion in spondylolytic spondylolisthesis: long-term results of Gill's procedure. (16676154)
2006
35
Rare bilateral C6 spondylolysis and spondylolisthesis in an adolescent athlete: evaluation with magnetic resonance imaging and multidetector computerized tomography. (17023845)
2006
36
Posterior lumbar interbody fusion versus intertransverse fusion in the treatment of lumbar spondylolisthesis. (16598082)
2006
37
Functional disability after instrumented stabilization in lumbar degenerative spondylolisthesis: a follow-up study. (16734999)
2006
38
Comparison of sagittal plane realignment and reduction with posterior instrumentation in developmental low or high dysplastic spondylolisthesis. (17329954)
2006
39
Posterior lumbar interbody fusion versus intertransverse fusion in the treatment of lumbar spondylolisthesis. (16914798)
2006
40
Reduction of severe adolescent isthmic spondylolisthesis: a new technique. (16205332)
2005
41
Reduction of spondylolisthesis. (15916409)
2002
42
Internal fixation systems in the surgical treatment of spondylolisthesis. (18034123)
2000
43
Iatrogenic spondylolysis leading to contralateral pedicular stress fracture and unstable spondylolisthesis: a case report. (10751305)
2000
44
Imaging of spondylolysis and spondylolisthesis. (8797997)
1996
45
Evaluation and management of spondylolysis and spondylolisthesis. (8111991)
1993
46
Treatment of spondylolysis and spondylolisthesis with Cotrel-Dubousset instrumentation: a preliminary report. (1839776)
1991
47
The incidence of spondylolysis and spondylolisthesis in nonambulatory patients. (7209672)
1981
48
Spondylolisthesis after multiple bilateral laminectomies and facetectomies for lumbar spondylosis. Follow-up review. (758378)
1979
49
Etiological considerations in spondylolysis and spondylolisthesis. (13952074)
1963
50
Spondylolysis and spondylolisthesis. (21066051)
1946

Genetic Variations for Spondylolisthesis

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Expression for genes affiliated with Spondylolisthesis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for genes affiliated with Spondylolisthesis

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51QIAGEN, 55SinoBiological, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Spondylolisthesis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0BMP2, BMP7
29.8GDF5, BMP2, BMP7
39.8GDF5, BMP2, BMP7
4
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9.8BMP7, BMP2, GDF5
5
Development Ligand-independent activation of ESR1 and ESR2
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9.5ESR1, PTGS2, NCOA1
6
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9.4BMP7, BMP2, GDF5, PTGS2
7
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9.2BMP7, BMP2, NCOA1, GDF5, PLA2G5
8
Hide members
9.1KLK8, BMP7, BMP2, GDF5, MMP3
9
Hide members
8.5ESR1, PTGS2, MMP3, GDF5, NCOA1, BMP2
10
Hide members
8.3PTGS2, GDF5, NCOA1, BMP2, BMP7, PSMD13

Compounds for genes affiliated with Spondylolisthesis

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1carboxymethylcellulose4410.3BMP2, BMP7
2safranin o4410.3BMP7, MMP3
3ketorolac44 1111.2PTGS2, BMP2
4[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.2ESR1, NCOA1
5butaprost4410.2PTGS2, MMP3
6polyglycolic acid4410.2BMP2, BMP7
7nimesulide44 1111.1MMP3, PTGS2
8alginate4410.1BMP7, BMP2, MMP3
9progestins4410.0PGRMC1, MMP3, ESR1
10alendronate44 49 1112.0ESR1, MMP3, BMP2
11glycosaminoglycan449.9MMP3, GDF5, BMP2
12risedronate44 59 49 28 1113.9ESR1, PTGS2
13leflunomide49 44 1111.9MMP3, PTGS2, ESR1
14piroxicam44 1110.9MMP3, PTGS2
15progestin449.9ESR1, MMP3, PGRMC1
16exemestane49 44 59 1112.9PTGS2, ESR1
17raloxifene44 28 49 1112.9ESR1, NCOA1, BMP2
18bisphenol a449.8ESR1, NCOA1
19ketoprofen44 28 1111.8MMP3, PTGS2
20ascorbic acid44 2410.8MMP3, FTH1, BMP2, BMP7
21resveratrol44 59 11 2412.7BMP2, PTGS2, ESR1
22mifepristone44 59 28 1112.6ESR1, PTGS2, MMP3, NCOA1
23rofecoxib44 49 28 1112.6PTGS2, MMP3
24indomethacin44 59 28 1112.6BMP2, NCOA1, MMP3, PTGS2
25vitamin d449.5BMP7, BMP2, NCOA1, MMP3, ESR1
26cycloheximide449.3BMP7, BMP2, MMP3, PTGS2, ESR1
27genistein44 28 59 2 11 2414.3BMP2, NCOA1, MMP3, PTGS2, ESR1
28progesterone44 59 28 11 2413.2BMP7, BMP2, NCOA1, PGRMC1, MMP3, ESR1
29vegf449.2BMP7, BMP2, MMP3, PTGS2, ESR1
30estrogen448.9BMP7, BMP2, NCOA1, PGRMC1, MMP3, PTGS2
31steroid448.6KLK8, LSS, BMP2, NCOA1, PGRMC1, ESR1

GO Terms for genes affiliated with Spondylolisthesis

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16Gene Ontology
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Biological processes related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1mesenchyme developmentGO:06048510.2BMP2, BMP7
2regulation of branching involved in prostate gland morphogenesisGO:06068710.0BMP7, ESR1
3mesenchymal cell differentiationGO:04876210.0BMP7, BMP2
4SMAD protein signal transductionGO:06039510.0BMP2, BMP7
5growthGO:04000710.0GDF5, BMP2, BMP7
6negative regulation of cell cycleGO:0457869.8BMP7, BMP2, PTGS2
7positive regulation of neuron differentiationGO:0456669.8NCOA1, BMP2, BMP7
8positive regulation of apoptotic processGO:0430659.3PTGS2, NCOA1, BMP2, BMP7
9extracellular matrix organizationGO:0301989.2BMP7, BMP2, GDF5, MMP3

Molecular functions related to Spondylolisthesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.1SDPR, AMIGO2, BMP7, BMP2, ARHGAP26, NCOA1

Products for genes affiliated with Spondylolisthesis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylolisthesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet