MCID: SPN019
MIFTS: 50

Spondylolisthesis malady

Bone diseases category
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Summaries for Spondylolisthesis

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Sources:
8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Spondylolisthesis is the forward displacement of a vertebra, especially the fifth lumbar vertebra, most... more...

MalaCards: Spondylolisthesis is related to spinal stenosis and spondylosis. An important gene associated with Spondylolisthesis is BMP7 (bone morphogenetic protein 7), and among its related pathways are Signaling by BMP and Cardiomyocyte Differentiation through BMP Receptors. The compounds safranin o and carboxymethylcellulose have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae and bone, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Disease Ontology:8 A bone structure disease that has material basis in displacement located in set of vertebrae.

Description from OMIM:47 184200

Aliases & Classifications for Spondylolisthesis

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 47OMIM, 35MeSH, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

spondylolisthesis 8 10 45 31 62


External Ids:

Disease Ontology8 DOID:6682
OMIM47 184200
MeSH35 D013168
NCIt40 C35033
ICD1025 M43.1

Related Diseases for Spondylolisthesis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1spinal stenosis31.1TSSK4, BMP7, LSS
2spondylosis30.6TSSK4
3degenerative disc disease30.5BMP2
4osteoarthritis30.1BMP7, MMP3, PTGS2, GDF5, BMP2
5spondylolysis11.0
6cervicitis10.6
7back pain10.5
8spina bifida10.3
9spina bifida occulta10.3
10neurofibromatosis10.2
11discitis10.2
12cauda equina syndrome10.2
13radiculopathy10.2
14osteogenesis imperfecta10.1
15obesity10.1
16lumbar disc disease10.1BMP2
17brachydactyly type a210.0BMP2, GDF5
18progressive osseous heteroplasia10.0BMP7, BMP2
19trigeminal neuralgia10.0PGRMC1, BMP2
20root resorption10.0GDF5, BMP2
21ankylosis10.0GDF5, BMP2
22bone carcinoma10.0BMP7, BMP2
23hemochromatosis10.0BMP2, FTH1
24arthropathy10.0MMP3, BMP2, BMP7
25chondrosarcoma10.0BMP7, MMP3, BMP2
26primary hyperoxaluria10.0FTH1, BMP7, PTGS2
27hypertrophy of breast10.0GDF5, BMP2, BMP7
28rheumatic disease10.0PTGS2, MMP3
29diabetes mellitus10.0BMP7, BMP2, FTH1, MMP3
30inflammatory bowel disease10.0PTGS2, MMP3, BMP7
31osteoporosis10.0BMP7, MMP3, BMP2, ESR1
32pseudoarthrosis10.0
33rubinstein-taybi syndrome10.0
34nevoid basal cell carcinoma syndrome10.0
35cerebritis10.0
36pycnodysostosis10.0
37gout10.0
38basal cell carcinoma10.0
39cerebral palsy10.0
40ehlers-danlos syndrome10.0
41osteomyelitis10.0
42sarcoidosis10.0
43tuberculosis10.0
44fibromatosis10.0
45inflammatory myofibroblastic tumor10.0
46jaffer beighton syndrome10.0
47endometriosis9.9MMP3, ESR1, PTGS2
48osteosarcoma9.9BMP7, BMP2, ESR1
49vascular disease9.9PTGS2, ESR1, MMP3, FTH1
50lung cancer9.9MMP3, PTGS2, BMP2

Graphical network of the top 20 diseases related to Spondylolisthesis:



Diseases related to spondylolisthesis

Symptoms for Spondylolisthesis

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47OMIM
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Clinical features from OMIM:

184200

Drugs & Therapeutics for Spondylolisthesis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Spondylolisthesis

Search NIH Clinical Center for Spondylolisthesis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spondylolisthesis

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Anatomical Context for Spondylolisthesis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Spondylolisthesis:

33
Bone

FMA organs/tissues related to Spondylolisthesis:

14
Set of vertebrae

Animal Models for Spondylolisthesis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Spondylolisthesis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0BMP7, BMP2, ESR1, GDF5
2MP:00053898.7GDF5, PTGS2, ESR1, BMP2, BMP7
3MP:00053908.4GDF5, PTGS2, ESR1, MMP3, BMP2, BMP7
4MP:00036318.0BMP2, FTH1, MMP3, ESR1, BMP7, PTGS2

Publications for Spondylolisthesis

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52PubMed
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Articles related to Spondylolisthesis:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Can low-grade spondylolisthesis be effectively treated by either coflex interlaminar stabilization or laminectomy and posterior spinal fusion? Two-year clinical and radiographic results from the randomized, prospective, multicenter US investigational device exemption trial: clinical article. (23725394)
2013
2
Variation in outcomes across centers after surgery for lumbar stenosis and degenerative spondylolisthesis in the spine patient outcomes research trial. (23080425)
2013
3
An in vitro model of degenerative lumbar spondylolisthesis. (23558441)
2013
4
Influencing segmental balance in isthmic spondylolisthesis using transforaminal lumbar interbody fusion. (22158301)
2013
5
Medium-term clinical results of microsurgical lumbar flavectomy that preserves facet joints in cases of lumbar degenerative spondylolisthesis: comparison of bilateral laminotomy with bilateral decompression by a unilateral approach. (22331069)
2013
6
Effects of a stabilization exercise program in functionality and pain in patients with degenerative spondylolisthesis. (23948848)
2013
7
Minimally invasive lateral retroperitoneal transpsoas interbody fusion for L4-5 spondylolisthesis: clinical outcomes. (23889186)
2013
8
Radiologic evaluation of degeneration in isthmic and degenerative spondylolisthesis. (23508359)
2013
9
Cost-utility of lumbar decompression with or without fusion for patients with symptomatic degenerative lumbar spondylolisthesis. (22169001)
2012
10
Spontaneous reduction finding: magnetic resonance imaging evaluation of segmental instability in spondylolisthesis. (23275804)
2012
11
Low grade lytic spondylolisthesis L4/L5 treated with PLIF. (21347753)
2011
12
High-grade child spondylolisthesis: a custom-made canulated screw to treat the so-called double instability. (21354887)
2011
13
Single-level posterolateral arthrodesis, with or without posterior decompression, for the treatment of isthmic spondylolisthesis. (21661679)
2011
14
Predominant leg pain is associated with better surgical outcomes in degenerative spondylolisthesis and spinal stenosis: results from the Spine Patient Outcomes Research Trial (SPORT). (21124260)
2011
15
Sacral fractures following stand-alone L5-S1 anterior lumbar interbody fusion for isthmic spondylolisthesis. (20672968)
2010
16
Radiographic analysis of newly developed degenerative spondylolisthesis in a mean twelve-year prospective study. (20354469)
2010
17
Chiropractic management of mechanical low back pain secondary to multiple-level lumbar spondylolysis with spondylolisthesis in a United States Marine Corps veteran: a case report. (19703668)
2009
18
An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spondylolisthesis. (19447684)
2009
19
Analysis of factors related to prognosis and curative effect for posterolateral fusion of lumbar low-grade isthmic spondylolisthesis. (18679680)
2009
20
Instrumented slip reduction and fusion for painful unstable isthmic spondylolisthesis in adults. (18836358)
2008
21
Progression of spondylolysis to isthmic spondylolisthesis in an adult without accompanying disc degeneration: a case report. (18411618)
2008
22
Union versus nonunion after posterolateral lumbar fusion: a comparison of long-term surgical outcomes in patients with degenerative lumbar spondylolisthesis. (18536941)
2008
23
Spine patient outcomes research trial: radiographic predictors of clinical outcomes after operative or nonoperative treatment of degenerative spondylolisthesis. (19050582)
2008
24
Clinical outcome of microendoscopic posterior decompression for spinal stenosis associated with degenerative spondylolisthesis--minimum 2-year outcome of 37 patients. (18855290)
2008
25
Uninstrumented in situ fusion for high-grade childhood and adolescent isthmic spondylolisthesis: long-term outcome. (17332099)
2007
26
Jackson's intrasacral fixation in the management of high-grade isthmic spondylolisthesis. (17159527)
2007
27
The radiographic results and neurologic complications of instrumented reduction and fusion of high-grade spondylolisthesis without decompression of the neural elements: a retrospective review of 44 patients. (16418634)
2006
28
Dynamic degenerative lumbar spondylolisthesis: diagnosis with axial loaded magnetic resonance imaging. (16648736)
2006
29
Chiropractic and rehabilitative management of a patient with progressive lumbar disk injury, spondylolisthesis, and spondyloptosis. (16396733)
2006
30
An unusual natural history of a L5-S1 spondylolisthesis presenting with a sacral insufficiency fracture. (16247630)
2006
31
Anterior transvertebral interbody cage with posterior transdiscal pedicle screw instrumentation for high-grade spondylolisthesis. Technical note. (16599423)
2006
32
Scoliosis research society outcome instrument in evaluation of long-term surgical results in spondylolysis and low-grade isthmic spondylolisthesis in young patients. (15682016)
2005
33
Residual neck pain after traumatic spondylolisthesis of the axis. (15800432)
2005
34
Abnormal motion in spondylolytic spondylolisthesis. (15897830)
2005
35
Spinal stenosis in grade I degenerative lumbar spondylolisthesis: a comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion. (15928889)
2005
36
Non-adjacent spondylolisthesis in ehlers-danlos syndrome. (15552563)
2004
37
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. (15534410)
2004
38
3D CT imaging of the lumbo-sacral spine after surgical treatment of L5-S1 spondylolisthesis by postero-lateral spondylodesis. (18034014)
2003
39
Spondylolysis and spondylolisthesis in the child and adolescent athlete. (12974495)
2003
40
Isthmic spondylolisthesis and spondylolysis. (12132828)
2001
41
Internal fixation systems in the surgical treatment of spondylolisthesis. (18034123)
2000
42
Management of spondylolysis and spondylolisthesis in the pediatric and adolescent population. (10393770)
1999
43
Evaluation of specific stabilizing exercise in the treatment of chronic low back pain with radiologic diagnosis of spondylolysis or spondylolisthesis. (9431633)
1997
44
SPECT evaluation of lumbar spondylolysis and spondylolisthesis. (8184357)
1994
45
Radiculopathy in spondylosis/spondylolisthesis. The laminar/ligamentum flavum process. (2980607)
1986
46
Scoliosis in young men with spondylolysis or spondylolisthesis. A comparative study in symptomatic and asymptomatic subjects. (6495008)
1984
47
Spondylolysis and spondylolisthesis in children. (6546062)
1983
48
Cervical spondylolisthesis associated with the multiple nevoid basal cell carcinoma syndrome. (7067221)
1982
49
Spondylolysis and spondylolisthesis. (544183)
1979
50
Spondylolisthesis without spondylolysis; degenerative changes in the apophyseal joints associated with subluxation in the lumbar spine. (13486340)
1957

Variations for Spondylolisthesis

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Expression for genes affiliated with Spondylolisthesis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for genes affiliated with Spondylolisthesis

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 57SinoBiological, 60Thomson Reuters
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Pathways related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BMP receptor signaling38
BMP signalling and regulation38
BMP Signalling Pathway38
9.8BMP7, BMP2
29.8BMP2, BMP7
39.6PTGS2, ESR1
49.6GDF5, BMP2, BMP7
5
Show member pathways
9.6GDF5, BMP2, BMP7
69.6BMP7, BMP2, GDF5
7
Show member pathways
9.6BMP7, BMP2, GDF5
8
Show member pathways
9.6GDF5, BMP2, BMP7
9
Show member pathways
9.4PTGS2, BMP2, BMP7
10
Show member pathways
9.2BMP2, MMP3, GDF5, BMP7
11
Show member pathways
9.2GDF5, PTGS2, BMP7, BMP2
12
Show member pathways
9.1ESR1, GDF5, BMP2, BMP7
13
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0PTGS2, MATK, ESR1
14
Show member pathways
8.7BMP7, BMP2, ESR1, PTGS2, GDF5
15
Show member pathways
8.6BMP7, GDF5, PTGS2, PSMD13, BMP2
16
Show member pathways
8.4BMP2, GDF5, PTGS2, ESR1, MMP3, BMP7

Compounds for genes affiliated with Spondylolisthesis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1safranin o4510.3BMP7, MMP3
2carboxymethylcellulose4510.3BMP7, BMP2
3polyglycolic acid4510.2BMP7, BMP2
4butaprost4510.1MMP3, PTGS2
5ketorolac45 1111.1PTGS2, BMP2
6titanium4510.1BMP2, BMP7
7nimesulide45 1111.1MMP3, PTGS2
8piroxicam45 1111.1PTGS2, MMP3
9ketoprofen29 45 1112.0MMP3, PTGS2
10rofecoxib45 51 29 1113.0PTGS2, MMP3
11sulfonamide4510.0MMP3, PTGS2
12danazol45 24 1112.0MMP3, ESR1
13risedronate45 51 29 61 1114.0ESR1, PTGS2
14levonorgestrel45 61 29 1112.9ESR1, MMP3
15exemestane45 51 61 1112.9PTGS2, ESR1
16alginate459.9BMP7, MMP3, BMP2
17triptolide459.9PTGS2, MMP3
18nacl459.9BMP7, FTH1, MMP3
19glycosaminoglycan459.9GDF5, BMP2, MMP3
20tgf beta1459.9BMP7, BMP2, MMP3
21sulfasalazine29 45 51 1112.8MMP3, PTGS2
22progestins459.8MMP3, ESR1, PGRMC1
23progestin459.8ESR1, MMP3, PGRMC1
24alendronate45 51 1111.7MMP3, ESR1, BMP2
25ndga459.7MMP3, PTGS2
26leflunomide45 51 1111.7MMP3, ESR1, PTGS2
27ribonucleic acid459.7BMP2, BMP7, MMP3
28mifepristone45 29 61 1112.7PTGS2, MMP3, ESR1
29ascorbic acid45 2410.6BMP2, FTH1, MMP3, BMP7
30etanercept45 51 1111.6PTGS2, MMP3
31resveratrol45 61 24 1112.6PTGS2, ESR1, BMP2
32indomethacin45 29 61 1112.5PTGS2, MMP3, BMP2
33iron45 2410.5PGRMC1, MMP3, FTH1, PTGS2
34pge2459.5MMP3, BMP7, BMP2, PTGS2
35vitamin d459.5BMP7, BMP2, MMP3, ESR1
36sb 20358045 6110.4BMP2, PTGS2, MMP3
37pd 98,059459.3BMP2, MMP3, PTGS2
38dexamethasone45 51 29 1112.3PTGS2, MMP3, BMP2, BMP7
39genistein45 29 61 3 24 1114.3PTGS2, BMP2, MMP3, ESR1
40oxygen45 2410.2BMP2, FTH1, PTGS2, MMP3, BMP7
41progesterone45 29 61 24 1113.2ESR1, MMP3, BMP2, BMP7, PGRMC1
42cycloheximide459.1BMP2, ESR1, PTGS2, MMP3, BMP7
43vegf459.0ESR1, PTGS2, BMP7, MMP3, BMP2
44steroid458.8BMP2, LSS, PGRMC1, ESR1
45estrogen458.8PGRMC1, PTGS2, ESR1, MMP3, BMP2, BMP7
46tyrosine458.3MATK, BMP7, BMP2, MMP3, GDF5

GO Terms for genes affiliated with Spondylolisthesis

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16Gene Ontology
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Biological processes related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1mesenchyme developmentGO:06048510.2BMP7, BMP2
2mesenchymal cell differentiationGO:04876210.1BMP2, BMP7
3SMAD protein signal transductionGO:06039510.1BMP2, BMP7
4response to vitamin DGO:03328010.0BMP7, PTGS2
5positive regulation of pathway-restricted SMAD protein phosphorylationGO:01086210.0BMP7, BMP2
6regulation of branching involved in prostate gland morphogenesisGO:06068710.0ESR1, BMP7
7positive regulation of bone mineralizationGO:03050110.0BMP2, BMP7
8epithelial to mesenchymal transitionGO:0018379.9BMP7, BMP2
9growthGO:0400079.9BMP7, BMP2, GDF5
10positive regulation of neuron differentiationGO:0456669.9GDF5, BMP2, BMP7
11positive regulation of nitric oxide biosynthetic processGO:0454299.8ESR1, PTGS2
12negative regulation of cell cycleGO:0457869.8BMP7, BMP2, PTGS2
13chondrocyte differentiationGO:0020629.7GDF5, BMP2
14bone mineralizationGO:0302829.7BMP2, PTGS2
15embryonic limb morphogenesisGO:0303269.6BMP7, GDF5
16response to estradiolGO:0323559.6BMP7, ESR1, PTGS2
17extracellular matrix organizationGO:0301989.5GDF5, MMP3, BMP2, BMP7
18positive regulation of apoptotic processGO:0430659.4BMP7, BMP2, PTGS2

Molecular functions related to Spondylolisthesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.7ESR1, PGRMC1
2growth factor activityGO:0080839.5GDF5, BMP2, BMP7
3cytokine activityGO:0051259.3BMP7, BMP2, GDF5
4protein bindingGO:0055157.1MATK, GDF5, AMIGO2, PGRMC1, ESR1, TSSK4

Products for genes affiliated with Spondylolisthesis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylolisthesis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet