MCID: SPN019
MIFTS: 45

Spondylolisthesis malady

Summaries for Spondylolisthesis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Spondylolisthesis is the forward displacement of a vertebra, especially the fifth lumbar vertebra, most... more...

MalaCards: Spondylolisthesis is related to spondylolysis and spinal stenosis. An important gene associated with Spondylolisthesis is BMP7 (bone morphogenetic protein 7), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and TGF-beta Signaling Pathway. The compounds carboxymethylcellulose and safranin o have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae and bone, and related mouse phenotype skeleton.

Disease Ontology:8 A bone structure disease that has material basis in displacement located in set of vertebrae.

Description from OMIM:46 184200

Aliases & Classifications for Spondylolisthesis

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 46OMIM, 34MeSH, 39NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

spondylolisthesis 8 10 44 30 60


External Ids:

Disease Ontology8 DOID:6682
OMIM46 184200
MeSH34 D013168
NCIt39 C35033
ICD1025 M43.1

Related Diseases for Spondylolisthesis

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17GeneCards, 18GeneDecks
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Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolysis31.4BMP7
2spinal stenosis30.9TSSK4, LSS, BMP7
3spondylosis30.4TSSK4
4degenerative disc disease30.3BMP2
5radiculopathy30.2KLK8, BMP2
6osteoarthritis30.2PTGS2, BMP2, GDF5, MMP3, BMP7
7cerebral palsy29.8AMIGO2
8cervicitis10.5
9spina bifida10.2
10neurofibromatosis10.2
11discitis10.2
12cauda equina syndrome10.2
13osteoporotic fracture10.1
14osteogenesis imperfecta10.1
15obesity10.1
16stroke, ischemic10.0BMP7
17galactosemia10.0FTH1
18parkinson's disease10.0GDF5
19synostosis10.0NCOA1
20sarcoma10.0BMP2
21smooth muscle tumor10.0ESR1
22osteonecrosis10.0BMP2
23trigeminal neuralgia10.0BMP2, PGRMC1
24lumbar disc disease10.0BMP2
25leiomyoma10.0ESR1, MMP3
26progressive osseous heteroplasia10.0BMP7, BMP2
27arthropathy10.0MMP3, BMP7, BMP2
28chondrosarcoma10.0MMP3, BMP2, BMP7
29adenoma10.0PTGS2
30diabetes mellitus10.0MMP3, FTH1, BMP2, BMP7
31osteosarcoma10.0ESR1, BMP2, BMP7
32osteoporosis10.0ESR1, MMP3, BMP2, BMP7
33rheumatoid arthritis10.0MMP3, BMP7, BMP2, PTGS2
34ovarian cancer10.0KLK8, BMP7, BMP2, NCOA1, ESR1
35atherosclerosis10.0LSS, MMP3, BMP2, PTGS2
36arthritis10.0MMP3, BMP7, BMP2, FTH1, GDF5, PTGS2
37adenocarcinoma10.0BMP2, NCOA1, PTGS2, ESR1, KLK8
38breast cancer9.9PTGS2, BMP2, BMP7, NCOA1, MATK, FTH1
39pseudoarthrosis9.9
40gout9.9
41rubinstein-taybi syndrome9.9
42cerebritis9.9
43nevoid basal cell carcinoma syndrome9.9
44pycnodysostosis9.9
45basal cell carcinoma9.9
46ehlers-danlos syndrome9.9
47osteomyelitis9.9
48sarcoidosis9.9
49tuberculosis9.9
50jaffer beighton syndrome9.9

Graphical network of the top 20 diseases related to Spondylolisthesis:



Diseases related to spondylolisthesis

Clinical Features for Spondylolisthesis

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46OMIM
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Clinical features from OMIM:

184200

Drugs & Therapeutics for Spondylolisthesis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spondylolisthesis

Drug clinical trials:

Search ClinicalTrials for Spondylolisthesis

Search NIH Clinical Center for Spondylolisthesis

Search CenterWatch for Spondylolisthesis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spondylolisthesis

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Anatomical Context for Spondylolisthesis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Spondylolisthesis:

32
Bone

FMA organs/tissues related to Spondylolisthesis:

14
Set of vertebrae

Animal Models for Spondylolisthesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spondylolisthesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5ESR1, PTGS2, MMP3, GDF5, NCOA1, BMP2

Publications for Spondylolisthesis

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50PubMed
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Articles related to Spondylolisthesis:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
A systematic review with meta-analysis of posterior interbody fusion versus posterolateral fusion in lumbar spondylolisthesis. (23812825)
2014
2
An in vitro model of degenerative lumbar spondylolisthesis. (23558441)
2013
3
Medium-term clinical results of microsurgical lumbar flavectomy that preserves facet joints in cases of lumbar degenerative spondylolisthesis: comparison of bilateral laminotomy with bilateral decompression by a unilateral approach. (22331069)
2013
4
Effects of a stabilization exercise program in functionality and pain in patients with degenerative spondylolisthesis. (23948848)
2013
5
No correlation between slip reduction in low-grade spondylolisthesis or change in neuroforaminal morphology and clinical outcome. (23957727)
2013
6
Spontaneous resolution of scoliosis associated with lumbar spondylolisthesis. (23415020)
2013
7
Trans-sacral screw fixation in the treatment of high dyplastic developmental spondylolisthesis. (24303480)
2013
8
Degenerative Spondylolisthesis does not Affect the Outcome of Unilateral Laminotomy With Bilateral Decompression in Patients With Lumbar Stenosis. (24365897)
2013
9
Outcomes of anterior lumbar interbody fusion in low-grade isthmic spondylolisthesis in adults: a continuous series of 65 cases with an average follow-up of 6.6 years. (23453913)
2013
10
Segmental spinal canal volume in patients with degenerative spondylolisthesis. (23541448)
2013
11
Does Navigation Improve Accuracy of Placement of Pedicle Screws in Single Level Lumbar Degenerative Spondylolisthesis? - A Comparison Between Free-hand and 3D O-Arm Navigation Techniques. (23981926)
2013
12
A slip above a slip: retrolisthesis of the motion segment above a spondylolytic spondylolisthesis. (22434532)
2012
13
A comparison of unilateral laminectomy with bilateral decompression and fusion surgery in the treatment of grade I lumbar degenerative spondylolisthesis. (22653494)
2012
14
Commentary: Interspinous devices, spondylolisthesis, and spinous process-related complications. (22857646)
2012
15
Spondylolisthesis accompanying bilateral pedicle stress fracture at two vertebrae. (22949973)
2012
16
Surgical results of degenerative spondylolisthesis patients over 70 years old: a single-center experience and clinical outcomes. (23015328)
2012
17
A radiographic analysis of degenerative spondylolisthesis at the L4-5 level. (22117143)
2012
18
Criteria to restore the sagittal balance in deformity and degenerative spondylolisthesis. (22411040)
2012
19
Comparative study of spinopelvic sagittal alignment between patients with and without degenerative spondylolisthesis. (22639298)
2012
20
Degenerative cervical spondylolisthesis: a systematic review. (21264670)
2011
21
Evaluation of the relationship between L5-S1 spondylolysis and isthmic spondylolisthesis and lumbosacral-pelvic morphology by imaging via 2- and 3-dimensional reformatted computed tomography. (21150453)
2011
22
Association of Enterococcus cecorum with vertebral osteomyelitis and spondylolisthesis in broiler parent chicks. (21354938)
2011
23
Globus sensation associated with cervical spondylolisthesis. (21430515)
2011
24
Spondylolisthesis in twins: multifactorial etiology: a case report and review of the literature. (21270694)
2011
25
Degenerative spondylolisthesis versus spinal stenosis: does a slip matter? Comparison of baseline characteristics and outcomes (SPORT). (20075768)
2010
26
Spondylolisthesis following a pedicle subtraction osteotomy. Case report. (20192661)
2010
27
Radiostereometric analysis of postoperative motion after application of dynesys dynamic posterior stabilization system for treatment of degenerative spondylolisthesis. (20072031)
2010
28
Fueling the debate: Are outcomes better after posterior lumbar interbody fusion (PLIF) or after posterolateral fusion (PLF) in adult patients with low-grade adult isthmic spondylolisthesis? (23544021)
2010
29
An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spondylolisthesis. (19447684)
2009
30
Spondylolisthesis and posterior instability. (19253068)
2009
31
Association between disc degeneration and degenerative spondylolisthesis? Pilot study. (20023360)
2009
32
Comparison between Instrumented Mini-TLIF and Instrumented Circumferential Fusion in Adult Low-Grade Lytic Spondylolisthesis : Can Mini-TLIF with PPF Replace Circumferential Fusion? (19274115)
2009
33
Disc displacement patterns in lumbar anterior spondylolisthesis: contribution to foraminal stenosis. (18243621)
2009
34
Posterior lumbar interbody fusion for adult isthmic spondylolisthesis: a comparison of fusion with one or two cages. (18827247)
2008
35
Perioperative complications of primary posterior lumbar interbody fusion for nonisthmic spondylolisthesis: analysis of risk factors. (18976169)
2008
36
A rare presentation of sarcoidosis, back pain and spondylolisthesis. (18256097)
2008
37
The Boxing boys of Akrotiri: early illustration of spondylolytic spondylolisthesis related to a sports injury. (17402177)
2007
38
Low-grade spondylolisthesis. (17556124)
2007
39
Anterior transvertebral interbody cage with posterior transdiscal pedicle screw instrumentation for high-grade spondylolisthesis. Technical note. (16599423)
2006
40
Surgical treatment of high-grade lumbosacral spondylolisthesis in childhood, adolescent and young adult by the "double-plate" technique: a past experience. (16429286)
2006
41
Lumbosacral nerve root anomaly associated with spondylolisthesis in an adolescent: a case report and review of the literature. (16946646)
2006
42
Anatomic reduction and monosegmental fusion in high-grade developmental spondylolisthesis. (16449898)
2006
43
Surgical management of spondylolisthesis overview of literature. (16565544)
2005
44
Spondylolysis and spondylolisthesis in the child and adolescent athlete. (12974495)
2003
45
Spondylolysis and spondylolisthesis in the pediatric and adolescent population. (11734982)
2001
46
Lumbar spondylosis, spondylolisthesis, neurogenic claudication, and L4 radiculopathy. (2562444)
1989
47
Scoliosis in young men with spondylolysis or spondylolisthesis. A comparative study in symptomatic and asymptomatic subjects. (6495008)
1984
48
Intraspinal enterogenous cyst associated with spondylolisthesis and spina bifida occulta. Report of a case. (4607613)
1974
49
SPONDYLOLYSIS AND SPONDYLOLISTHESIS FOLLOWING LOW BACK FUSIONS. (14175440)
1964
50
Spondylolisthesis and spondylolysis: a clinicostatistical report on 589 cases treated over a thirteen year period (1945 through 1958). (14421035)
1960

Genetic Variations for Spondylolisthesis

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Expression for genes affiliated with Spondylolisthesis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for genes affiliated with Spondylolisthesis

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51QIAGEN, 55SinoBiological, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Spondylolisthesis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0BMP2, BMP7
29.8GDF5, BMP2, BMP7
39.8GDF5, BMP2, BMP7
4
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9.8BMP7, BMP2, GDF5
5
Development Ligand-independent activation of ESR1 and ESR2
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9.5ESR1, PTGS2, NCOA1
6
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9.4BMP7, BMP2, GDF5, PTGS2
7
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9.2BMP7, BMP2, NCOA1, GDF5, PLA2G5
8
Hide members
9.1KLK8, BMP7, BMP2, GDF5, MMP3
9
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8.5ESR1, PTGS2, MMP3, GDF5, NCOA1, BMP2
10
Hide members
8.3PTGS2, GDF5, NCOA1, BMP2, BMP7, PSMD13

Compounds for genes affiliated with Spondylolisthesis

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1carboxymethylcellulose4410.3BMP2, BMP7
2safranin o4410.3BMP7, MMP3
3ketorolac44 1111.2PTGS2, BMP2
4[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.2ESR1, NCOA1
5butaprost4410.2PTGS2, MMP3
6polyglycolic acid4410.2BMP2, BMP7
7nimesulide44 1111.1MMP3, PTGS2
8alginate4410.1BMP7, BMP2, MMP3
9progestins4410.0PGRMC1, MMP3, ESR1
10alendronate44 49 1112.0ESR1, MMP3, BMP2
11glycosaminoglycan449.9MMP3, GDF5, BMP2
12risedronate44 59 49 28 1113.9ESR1, PTGS2
13leflunomide49 44 1111.9MMP3, PTGS2, ESR1
14piroxicam44 1110.9MMP3, PTGS2
15progestin449.9ESR1, MMP3, PGRMC1
16exemestane49 44 59 1112.9PTGS2, ESR1
17raloxifene44 28 49 1112.9ESR1, NCOA1, BMP2
18bisphenol a449.8ESR1, NCOA1
19ketoprofen44 28 1111.8MMP3, PTGS2
20ascorbic acid44 2410.8MMP3, FTH1, BMP2, BMP7
21resveratrol44 59 11 2412.7BMP2, PTGS2, ESR1
22mifepristone44 59 28 1112.6ESR1, PTGS2, MMP3, NCOA1
23rofecoxib44 49 28 1112.6PTGS2, MMP3
24indomethacin44 59 28 1112.6BMP2, NCOA1, MMP3, PTGS2
25vitamin d449.5BMP7, BMP2, NCOA1, MMP3, ESR1
26cycloheximide449.3BMP7, BMP2, MMP3, PTGS2, ESR1
27genistein44 28 59 2 11 2414.3BMP2, NCOA1, MMP3, PTGS2, ESR1
28progesterone44 59 28 11 2413.2BMP7, BMP2, NCOA1, PGRMC1, MMP3, ESR1
29vegf449.2BMP7, BMP2, MMP3, PTGS2, ESR1
30estrogen448.9BMP7, BMP2, NCOA1, PGRMC1, MMP3, PTGS2
31steroid448.6KLK8, LSS, BMP2, NCOA1, PGRMC1, ESR1

GO Terms for genes affiliated with Spondylolisthesis

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16Gene Ontology
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Biological processes related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1mesenchyme developmentGO:06048510.2BMP2, BMP7
2regulation of branching involved in prostate gland morphogenesisGO:06068710.0BMP7, ESR1
3mesenchymal cell differentiationGO:04876210.0BMP7, BMP2
4SMAD protein signal transductionGO:06039510.0BMP2, BMP7
5growthGO:04000710.0GDF5, BMP2, BMP7
6negative regulation of cell cycleGO:0457869.8BMP7, BMP2, PTGS2
7positive regulation of neuron differentiationGO:0456669.8NCOA1, BMP2, BMP7
8positive regulation of apoptotic processGO:0430659.3PTGS2, NCOA1, BMP2, BMP7
9extracellular matrix organizationGO:0301989.2BMP7, BMP2, GDF5, MMP3

Molecular functions related to Spondylolisthesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.1SDPR, AMIGO2, BMP7, BMP2, ARHGAP26, NCOA1

Products for genes affiliated with Spondylolisthesis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylolisthesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet