MCID: SPN019
MIFTS: 45

Spondylolisthesis malady

Summaries for Spondylolisthesis

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Spondylolisthesis is the anterior or posterior displacement of a vertebra or the vertebral column in... more...

MalaCards: Spondylolisthesis is related to spondylolysis and spinal stenosis. An important gene associated with Spondylolisthesis is BMP7 (bone morphogenetic protein 7), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and TGF-beta Signaling Pathway. The compounds carboxymethylcellulose and safranin o have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae, skeletal muscle and t cells, and related mouse phenotype skeleton.

Disease Ontology:8 A bone structure disease that has material basis in displacement located in set of vertebrae.

Description from OMIM:47 184200

Aliases & Classifications for Spondylolisthesis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 47OMIM, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

spondylolisthesis 8 10 45 31 61


External Ids:

Disease Ontology8 DOID:6682
OMIM47 184200
MeSH35 D013168
NCIt40 C35033
ICD1025 M43.1

Related Diseases for Spondylolisthesis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolysis31.4BMP7
2spinal stenosis30.9LSS, BMP7, TSSK4
3spondylosis30.4TSSK4
4degenerative disc disease30.3BMP2
5radiculopathy30.2KLK8, BMP2
6lumbar disc disease30.2BMP2
7osteoarthritis30.2BMP7, BMP2, GDF5, MMP3, PTGS2
8back pain10.5
9spina bifida10.2
10spina bifida occulta10.2
11neurofibromatosis10.2
12discitis10.2
13cauda equina syndrome10.2
14osteoporotic fracture10.1
15osteogenesis imperfecta10.1
16idiopathic adolescent scoliosis10.1
17chronic pain10.1
18cerebral palsy10.0AMIGO2
19stroke, ischemic10.0BMP7
20galactosemia10.0FTH1
21parkinson's disease10.0GDF5
22synostosis10.0NCOA1
23sarcoma10.0BMP2
24smooth muscle tumor10.0ESR1
25osteonecrosis10.0BMP2
26trigeminal neuralgia10.0PGRMC1, BMP2
27leiomyoma10.0ESR1, MMP3
28progressive osseous heteroplasia10.0BMP2, BMP7
29arthropathy10.0MMP3, BMP2, BMP7
30chondrosarcoma10.0MMP3, BMP2, BMP7
31adenoma10.0PTGS2
32diabetes mellitus10.0BMP7, BMP2, FTH1, MMP3
33osteosarcoma10.0ESR1, BMP2, BMP7
34osteoporosis10.0BMP7, BMP2, MMP3, ESR1
35rheumatoid arthritis10.0BMP7, BMP2, MMP3, PTGS2
36ovarian cancer10.0KLK8, BMP7, BMP2, NCOA1, ESR1
37atherosclerosis10.0LSS, BMP2, MMP3, PTGS2
38arthritis10.0BMP7, BMP2, FTH1, GDF5, MMP3, PTGS2
39adenocarcinoma10.0ESR1, PTGS2, NCOA1, BMP2, KLK8
40breast cancer9.9BMP7, BMP2, NCOA1, MATK, FTH1, PGRMC1
41pseudoarthrosis9.9
42gout9.9
43rubinstein-taybi syndrome9.9
44nevoid basal cell carcinoma syndrome9.9
45pycnodysostosis9.9
46n syndrome9.9
47basal cell carcinoma9.9
48tuberculosis9.9
49ehlers–danlos syndrome9.9
50jaffer beighton syndrome9.9

Graphical network of the top 20 diseases related to Spondylolisthesis:



Diseases related to spondylolisthesis

Clinical Features for Spondylolisthesis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

184200

Drugs & Therapeutics for Spondylolisthesis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spondylolisthesis

Drug clinical trials:

Search ClinicalTrials for Spondylolisthesis

Search NIH Clinical Center for Spondylolisthesis

Search CenterWatch for Spondylolisthesis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spondylolisthesis

Anatomical Context for Spondylolisthesis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Spondylolisthesis:

33
Skeletal muscle, T cells, B cells

FMA organs/tissues related to Spondylolisthesis:

14
Set of vertebrae

Animal Models for Spondylolisthesis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Spondylolisthesis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.5ESR1, PTGS2, MMP3, GDF5, NCOA1, BMP2

Publications for Spondylolisthesis

Sources:
51PubMed
See all sources

Articles related to Spondylolisthesis:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Decompression and Coflex interlaminar stabilization compared with decompression and instrumented spinal fusion for spinal stenosis and low-grade degenerative spondylolisthesis: two-year results from the prospective, randomized, multicenter, Food and Drug Administration Investigational Device Exemption trial. (23680830)
2013
2
Comparison of minimally invasive fusion and instrumentation versus open surgery for severe stenotic spondylolisthesis with high-grade facet joint osteoarthritis. (23479028)
2013
3
Spondylolisthesis, Sacro-pelvic Morphology and Orientation in Young Gymnasts. (24201157)
2013
4
Treatment of multilevel degenerative lumbar spinal stenosis with spondylolisthesis using a combination of microendoscopic discectomy and minimally invasive transforaminal lumbar interbody fusion. (23403827)
2013
5
Limited access surgery for 360 degrees in-situ fusion in a dysraphic patient with high-grade spondylolisthesis. (22008862)
2012
6
Transdiscal L5-S1 screws for the treatment of adult spondylolisthesis. (22402843)
2012
7
Minimally invasive transforaminal lumbar interbody fusion and spondylolisthesis. (22386479)
2012
8
Surgery for lumbar degenerative spondylolisthesis in Spine Patient Outcomes Research Trial: does incidental durotomy affect outcome? (21971123)
2012
9
Spondylolisthesis: a pictorial review. (23502198)
2012
10
Reliability of the Spinal Deformity Study Group classification of lumbosacral spondylolisthesis. (21629167)
2012
11
Association between degenerative spondylolisthesis and spinous process fracture after interspinous process spacer surgery. (22622239)
2012
12
Predominant leg pain is associated with better surgical outcomes in degenerative spondylolisthesis and spinal stenosis: results from the Spine Patient Outcomes Research Trial (SPORT). (21124260)
2011
13
Posterior lumbar interbody fusion versus posterolateral fusion with instrumentation in the treatment of low-grade isthmic spondylolisthesis: midterm clinical outcomes. (21314280)
2011
14
Evaluation of the relationship between L5-S1 spondylolysis and isthmic spondylolisthesis and lumbosacral-pelvic morphology by imaging via 2- and 3-dimensional reformatted computed tomography. (21150453)
2011
15
Operative treatment of isthmic spondylolisthesis in children: a long-term, retrospective comparative study with matched cohorts. (20960014)
2011
16
Sagittal spinopelvic alignment and body mass index in patients with degenerative spondylolisthesis. (21116661)
2011
17
Spino-pelvic sagittal balance of spondylolisthesis: a review and classification. (21809015)
2011
18
Smaller facet effusion in association with restabilization at the time of operation in Japanese patients with lumbar degenerative spondylolisthesis. (20043770)
2010
19
Which lumbar interbody fusion technique is better in terms of level for the treatment of unstable isthmic spondylolisthesis? (20121352)
2010
20
Analysis of spinopelvic parameters in lumbar degenerative kyphosis: correlation with spinal stenosis and spondylolisthesis. (21030897)
2010
21
Reduction and transforaminal lumbar interbody fusion with posterior fixation versus transsacral cage fusion in situ with posterior fixation in the treatment of Grade 2 adult isthmic spondylolisthesis in the lumbosacral spine. (20809736)
2010
22
Degenerative lumbar spondylolisthesis: evolution of surgical management. (19560055)
2009
23
Imaging correlation of the degree of degenerative L4-5 spondylolisthesis with the corresponding amount of facet fluid. (19929367)
2009
24
Matrix metalloproteinase-3 on ligamentum flavum in degenerative lumbar spondylolisthesis. (19770597)
2009
25
Disc displacement patterns in lumbar anterior spondylolisthesis: contribution to foraminal stenosis. (18243621)
2009
26
Transsacral screw fixation for high-grade spondylolisthesis. (19819760)
2009
27
Facet joint orientation in spondylolysis and isthmic spondylolisthesis. (18391715)
2008
28
Anterior cervical discectomy and fusion for unstable traumatic spondylolisthesis of the axis. (18303456)
2008
29
Uninstrumented in situ fusion for high-grade childhood and adolescent isthmic spondylolisthesis: long-term outcome. Surgical technique. (18310693)
2008
30
Comparative study of PILF and TLIF treatment in adult degenerative spondylolisthesis. (18685873)
2008
31
Spino-pelvic alignment after surgical correction for developmental spondylolisthesis. (18600350)
2008
32
Uninstrumented in situ fusion for high-grade childhood and adolescent isthmic spondylolisthesis: long-term outcome. (17332099)
2007
33
Acute traumatic spondylolisthesis at the lumbosacral junction. (17110886)
2007
34
Interbody fusion and transpedicular fixation in the treatment of spondylolisthesis. (17514167)
2007
35
High-grade lumbosacral spondylolisthesis in children and adolescents: pathogenesis, morphological analysis, and therapeutic strategy. (17632029)
2007
36
Acute traumatic L5-S1 spondylolisthesis: a case report. (16333633)
2006
37
Treatment of instability and spondylolisthesis: surgical versus nonsurgical treatment. (16462445)
2006
38
Surgical treatment of high-grade spondylolisthesis. (16876032)
2006
39
Residual neck pain after traumatic spondylolisthesis of the axis. (15800432)
2005
40
High-grade dysplastic spondylolisthesis and spondyloptosis: report of three cases with surgical treatment and review of the literature. (16459872)
2005
41
No correlation between patient outcome and abnormal lumbar MRI findings 21 years after posterior or posterolateral fusion for isthmic spondylolisthesis in children and adolescents. (16151711)
2005
42
Spondylolysis and spondylolisthesis: a narrative review of etiology, diagnosis, and conservative management. (19674664)
2005
43
Non-adjacent spondylolisthesis in ehlers-danlos syndrome. (15552563)
2004
44
No difference in clinical outcome after posterolateral lumbar fusion between patients with isthmic spondylolisthesis and those with degenerative disc disease using pedicle screw instrumentation: a comparative study of 112 patients with 4 years of follow-up. (12384748)
2002
45
Evaluation of specific stabilizing exercise in the treatment of chronic low back pain with radiologic diagnosis of spondylolysis or spondylolisthesis. (9431633)
1997
46
Surgical treatment of spondylolysis and spondylolisthesis with a hook screw. (8021074)
1994
47
Imaging of the lumbar spine in spondylolysis and spondylolisthesis. (2252534)
1990
48
Radiculopathy in spondylosis/spondylolisthesis. The laminar/ligamentum flavum process. (2980607)
1986
49
Review of spondylolisthesis and spondylolysis in paediatric practice. (6237709)
1984
50
Spondylolisthesis and spondylolysis: a clinicostatistical report on 589 cases treated over a thirteen year period (1945 through 1958). (14421035)
1960

Genetic Variations for Spondylolisthesis

Expression for genes affiliated with Spondylolisthesis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for genes affiliated with Spondylolisthesis

Sources:
52QIAGEN, 56SinoBiological, 30KEGG, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Spondylolisthesis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0BMP2, BMP7
29.8GDF5, BMP2, BMP7
39.8GDF5, BMP2, BMP7
4
Hide members
9.8BMP7, BMP2, GDF5
5
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.5ESR1, PTGS2, NCOA1
6
Hide members
9.4BMP7, BMP2, GDF5, PTGS2
7
Hide members
9.2BMP7, BMP2, NCOA1, GDF5, PLA2G5
8
Hide members
9.1KLK8, BMP7, BMP2, GDF5, MMP3
9
Hide members
8.5ESR1, PTGS2, MMP3, GDF5, NCOA1, BMP2
10
Hide members
8.3PTGS2, GDF5, NCOA1, BMP2, BMP7, PSMD13

Compounds for genes affiliated with Spondylolisthesis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1carboxymethylcellulose4510.3BMP2, BMP7
2safranin o4510.3BMP7, MMP3
3ketorolac45 1111.2PTGS2, BMP2
4[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.2ESR1, NCOA1
5butaprost4510.2PTGS2, MMP3
6polyglycolic acid4510.2BMP2, BMP7
7nimesulide45 1111.1MMP3, PTGS2
8alginate4510.1BMP7, BMP2, MMP3
9progestins4510.0PGRMC1, MMP3, ESR1
10alendronate45 50 1112.0ESR1, MMP3, BMP2
11glycosaminoglycan459.9MMP3, GDF5, BMP2
12risedronate45 60 50 29 1113.9ESR1, PTGS2
13leflunomide50 45 1111.9MMP3, PTGS2, ESR1
14piroxicam45 1110.9MMP3, PTGS2
15progestin459.9ESR1, MMP3, PGRMC1
16exemestane50 45 60 1112.9PTGS2, ESR1
17raloxifene45 29 50 1112.9ESR1, NCOA1, BMP2
18bisphenol a459.8ESR1, NCOA1
19ketoprofen45 29 1111.8MMP3, PTGS2
20ascorbic acid45 2410.8MMP3, FTH1, BMP2, BMP7
21resveratrol45 60 11 2412.7BMP2, PTGS2, ESR1
22mifepristone45 60 29 1112.6ESR1, PTGS2, MMP3, NCOA1
23rofecoxib45 50 29 1112.6PTGS2, MMP3
24indomethacin45 60 29 1112.6BMP2, NCOA1, MMP3, PTGS2
25vitamin d459.5BMP7, BMP2, NCOA1, MMP3, ESR1
26cycloheximide459.3BMP7, BMP2, MMP3, PTGS2, ESR1
27genistein45 29 60 2 11 2414.3BMP2, NCOA1, MMP3, PTGS2, ESR1
28progesterone45 60 29 11 2413.2BMP7, BMP2, NCOA1, PGRMC1, MMP3, ESR1
29vegf459.2BMP7, BMP2, MMP3, PTGS2, ESR1
30estrogen458.9BMP7, BMP2, NCOA1, PGRMC1, MMP3, PTGS2
31steroid458.6KLK8, LSS, BMP2, NCOA1, PGRMC1, ESR1

GO Terms for genes affiliated with Spondylolisthesis

Sources:
16Gene Ontology
See all sources

Biological processes related to Spondylolisthesis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1mesenchyme developmentGO:06048510.2BMP2, BMP7
2regulation of branching involved in prostate gland morphogenesisGO:06068710.0BMP7, ESR1
3mesenchymal cell differentiationGO:04876210.0BMP7, BMP2
4SMAD protein signal transductionGO:06039510.0BMP2, BMP7
5growthGO:04000710.0GDF5, BMP2, BMP7
6negative regulation of cell cycleGO:0457869.8BMP7, BMP2, PTGS2
7positive regulation of neuron differentiationGO:0456669.8NCOA1, BMP2, BMP7
8positive regulation of apoptotic processGO:0430659.3PTGS2, NCOA1, BMP2, BMP7
9extracellular matrix organizationGO:0301989.2BMP7, BMP2, GDF5, MMP3

Molecular functions related to Spondylolisthesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.1SDPR, AMIGO2, BMP7, BMP2, ARHGAP26, NCOA1

Products for genes affiliated with Spondylolisthesis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylolisthesis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet