MCID: SPN019
MIFTS: 45

Spondylolisthesis malady

Summaries for Spondylolisthesis

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Wikipedia:63 Spondylolisthesis is the forward displacement of a vertebra, especially the fifth lumbar vertebra, most... more...

MalaCards based summary: Spondylolisthesis is related to spinal stenosis and spondylosis, and has symptoms including autosomal dominant inheritance, spondylolysis and spondylolisthesis at l5-s1. An important gene associated with Spondylolisthesis is BMP7 (bone morphogenetic protein 7), and among its related pathways are Signaling by BMP and Cardiomyocyte Differentiation through BMP Receptors. The compounds safranin o and carboxymethylcellulose have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae, bone and testes, and related mouse phenotypes are limbs/digits/tail and reproductive system.

Disease Ontology:9 A bone structure disease that has material basis in displacement located in set of vertebrae.

Aliases & Classifications for Spondylolisthesis

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Spondylolisthesis, Aliases & Descriptions:

Name: Spondylolisthesis 30 9 11 43 60


Classifications:



External Ids:

Disease Ontology9 DOID:6682
NCIt38 C35033
MeSH33 D013168
ICD1025 M43.1

Related Diseases for Spondylolisthesis

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Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1spinal stenosis31.4TSSK4, BMP7, LSS
2spondylosis31.1TSSK4
3degenerative disc disease30.9BMP2
4osteoarthritis29.6BMP7, MMP3, PTGS2, GDF5, BMP2
5spondylolysis11.0
6cervicitis10.6
7scoliosis10.5
8back pain10.5
9spina bifida occulta10.3
10intervertebral disc disease10.3BMP2
11brachydactyly, type a210.2BMP2, GDF5
12osseous heteroplasia, progressive10.2BMP7, BMP2
13trigeminal neuralgia10.2PGRMC1, BMP2
14discitis10.2
15neurofibromatosis10.2
16cauda equina syndrome10.2
17radiculopathy10.2
18idiopathic scoliosis10.2
19root resorption10.2GDF5, BMP2
20ankylosis10.1GDF5, BMP2
21bone cancer10.1BMP7, BMP2
22pycnodysostosis10.1
23obesity10.1
24osteogenesis imperfecta10.1
25hemochromatosis10.0BMP2, FTH1
26arthropathy10.0MMP3, BMP2, BMP7
27chondrosarcoma10.0BMP7, MMP3, BMP2
28kidney disease10.0FTH1, BMP7, PTGS2
29aspartylglucosaminuria10.0
30cleidocranial dysplasia10.0
31marfan syndrome10.0
32brittle cornea syndrome 110.0
33koolen-de vries syndrome10.0
34rubinstein-taybi syndrome10.0
35loeys-dietz syndrome, type 410.0
36loeys-dietz syndrome, type 310.0
37mannosidosis, alpha-, types i and ii10.0
38cerebral palsy10.0
39pseudoarthrosis10.0
40inflammatory myofibroblastic tumor10.0
41cerebritis10.0
42gout10.0
43basal cell carcinoma10.0
44ehlers-danlos syndrome10.0
45osteomyelitis10.0
46tuberculosis10.0
47fibromatosis10.0
48jaffer beighton syndrome10.0
49rheumatic disease9.9PTGS2, MMP3
50diabetes mellitus, insulin-dependent9.9BMP7, BMP2, FTH1, MMP3

Graphical network of the top 20 diseases related to Spondylolisthesis:



Diseases related to spondylolisthesis

Symptoms for Spondylolisthesis

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HPO human phenotypes related to Spondylolisthesis:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 spondylolysis HP:0003304
3 spondylolisthesis at l5-s1 HP:0008489

Drugs & Therapeutics for Spondylolisthesis

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Drug clinical trials:

Search ClinicalTrials for Spondylolisthesis

Search NIH Clinical Center for Spondylolisthesis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spondylolisthesis

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Anatomical Context for Spondylolisthesis

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MalaCards organs/tissues related to Spondylolisthesis:

31
Bone, Testes

FMA organs/tissues related to Spondylolisthesis:

14
Set of vertebrae

Animal Models for Spondylolisthesis or affiliated genes

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MGI Mouse Phenotypes related to Spondylolisthesis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0GDF5, ESR1, BMP2, BMP7
2MP:00053898.7BMP7, BMP2, ESR1, PTGS2, GDF5
3MP:00053908.4BMP7, BMP2, MMP3, ESR1, PTGS2, GDF5
4MP:00036318.0PTGS2, ESR1, MMP3, FTH1, BMP2, BMP7

Publications for Spondylolisthesis

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Articles related to Spondylolisthesis:

(show top 50)    (show all 648)
idTitleAuthorsYear
1
Kinematic Analysis of Diseased and Adjacent Segments in Degenerative Lumbar Spondylolisthesis. (25220670)
2014
2
Can low-grade spondylolisthesis be effectively treated by either coflex interlaminar stabilization or laminectomy and posterior spinal fusion? Two-year clinical and radiographic results from the randomized, prospective, multicenter US investigational device exemption trial: clinical article. (23725394)
2013
3
Variation in outcomes across centers after surgery for lumbar stenosis and degenerative spondylolisthesis in the spine patient outcomes research trial. (23080425)
2013
4
An in vitro model of degenerative lumbar spondylolisthesis. (23558441)
2013
5
Influencing segmental balance in isthmic spondylolisthesis using transforaminal lumbar interbody fusion. (22158301)
2013
6
Medium-term clinical results of microsurgical lumbar flavectomy that preserves facet joints in cases of lumbar degenerative spondylolisthesis: comparison of bilateral laminotomy with bilateral decompression by a unilateral approach. (22331069)
2013
7
Minimally invasive lateral retroperitoneal transpsoas interbody fusion for L4-5 spondylolisthesis: clinical outcomes. (23889186)
2013
8
Radiologic evaluation of degeneration in isthmic and degenerative spondylolisthesis. (23508359)
2013
9
Cost-utility of lumbar decompression with or without fusion for patients with symptomatic degenerative lumbar spondylolisthesis. (22169001)
2012
10
Spontaneous reduction finding: magnetic resonance imaging evaluation of segmental instability in spondylolisthesis. (23275804)
2012
11
Low grade lytic spondylolisthesis L4/L5 treated with PLIF. (21347753)
2011
12
High-grade child spondylolisthesis: a custom-made canulated screw to treat the so-called double instability. (21354887)
2011
13
Single-level posterolateral arthrodesis, with or without posterior decompression, for the treatment of isthmic spondylolisthesis. (21661679)
2011
14
Predominant leg pain is associated with better surgical outcomes in degenerative spondylolisthesis and spinal stenosis: results from the Spine Patient Outcomes Research Trial (SPORT). (21124260)
2011
15
Sacral fractures following stand-alone L5-S1 anterior lumbar interbody fusion for isthmic spondylolisthesis. (20672968)
2010
16
Radiographic analysis of newly developed degenerative spondylolisthesis in a mean twelve-year prospective study. (20354469)
2010
17
Smaller facet effusion in association with restabilization at the time of operation in Japanese patients with lumbar degenerative spondylolisthesis. (20043770)
2010
18
An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spondylolisthesis. (19447684)
2009
19
Analysis of factors related to prognosis and curative effect for posterolateral fusion of lumbar low-grade isthmic spondylolisthesis. (18679680)
2009
20
Instrumented slip reduction and fusion for painful unstable isthmic spondylolisthesis in adults. (18836358)
2008
21
Progression of spondylolysis to isthmic spondylolisthesis in an adult without accompanying disc degeneration: a case report. (18411618)
2008
22
Union versus nonunion after posterolateral lumbar fusion: a comparison of long-term surgical outcomes in patients with degenerative lumbar spondylolisthesis. (18536941)
2008
23
Spine patient outcomes research trial: radiographic predictors of clinical outcomes after operative or nonoperative treatment of degenerative spondylolisthesis. (19050582)
2008
24
Clinical outcome of microendoscopic posterior decompression for spinal stenosis associated with degenerative spondylolisthesis--minimum 2-year outcome of 37 patients. (18855290)
2008
25
Uninstrumented in situ fusion for high-grade childhood and adolescent isthmic spondylolisthesis: long-term outcome. (17332099)
2007
26
Jackson's intrasacral fixation in the management of high-grade isthmic spondylolisthesis. (17159527)
2007
27
The radiographic results and neurologic complications of instrumented reduction and fusion of high-grade spondylolisthesis without decompression of the neural elements: a retrospective review of 44 patients. (16418634)
2006
28
Dynamic degenerative lumbar spondylolisthesis: diagnosis with axial loaded magnetic resonance imaging. (16648736)
2006
29
Chiropractic and rehabilitative management of a patient with progressive lumbar disk injury, spondylolisthesis, and spondyloptosis. (16396733)
2006
30
An unusual natural history of a L5-S1 spondylolisthesis presenting with a sacral insufficiency fracture. (16247630)
2006
31
Anterior transvertebral interbody cage with posterior transdiscal pedicle screw instrumentation for high-grade spondylolisthesis. Technical note. (16599423)
2006
32
Scoliosis research society outcome instrument in evaluation of long-term surgical results in spondylolysis and low-grade isthmic spondylolisthesis in young patients. (15682016)
2005
33
Residual neck pain after traumatic spondylolisthesis of the axis. (15800432)
2005
34
Abnormal motion in spondylolytic spondylolisthesis. (15897830)
2005
35
Spinal stenosis in grade I degenerative lumbar spondylolisthesis: a comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion. (15928889)
2005
36
Non-adjacent spondylolisthesis in ehlers-danlos syndrome. (15552563)
2004
37
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. (15534410)
2004
38
3D CT imaging of the lumbo-sacral spine after surgical treatment of L5-S1 spondylolisthesis by postero-lateral spondylodesis. (18034014)
2003
39
Spondylolysis and spondylolisthesis in the child and adolescent athlete. (12974495)
2003
40
Isthmic spondylolisthesis and spondylolysis. (12132828)
2001
41
Internal fixation systems in the surgical treatment of spondylolisthesis. (18034123)
2000
42
Management of spondylolysis and spondylolisthesis in the pediatric and adolescent population. (10393770)
1999
43
Evaluation of specific stabilizing exercise in the treatment of chronic low back pain with radiologic diagnosis of spondylolysis or spondylolisthesis. (9431633)
1997
44
SPECT evaluation of lumbar spondylolysis and spondylolisthesis. (8184357)
1994
45
Radiculopathy in spondylosis/spondylolisthesis. The laminar/ligamentum flavum process. (2980607)
1986
46
Scoliosis in young men with spondylolysis or spondylolisthesis. A comparative study in symptomatic and asymptomatic subjects. (6495008)
1984
47
Spondylolysis and spondylolisthesis in children. (6546062)
1983
48
Cervical spondylolisthesis associated with the multiple nevoid basal cell carcinoma syndrome. (7067221)
1982
49
Spondylolysis and spondylolisthesis. (544183)
1979
50
Spondylolisthesis without spondylolysis; degenerative changes in the apophyseal joints associated with subluxation in the lumbar spine. (13486340)
1957

Variations for Spondylolisthesis

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Expression for genes affiliated with Spondylolisthesis

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Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for genes affiliated with Spondylolisthesis

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Pathways related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BMP receptor signaling36
BMP signalling and regulation36
BMP Signalling Pathway36
9.8BMP7, BMP2
29.8BMP2, BMP7
39.6PTGS2, ESR1
49.6BMP7, BMP2, GDF5
5
Show member pathways
9.6BMP7, BMP2, GDF5
69.6GDF5, BMP2, BMP7
7
Show member pathways
9.6GDF5, BMP2, BMP7
8
Show member pathways
9.6BMP7, BMP2, GDF5
9
Show member pathways
9.4BMP7, BMP2, PTGS2
10
Show member pathways
9.2BMP7, BMP2, MMP3, GDF5
11
Show member pathways
9.2GDF5, PTGS2, BMP2, BMP7
12
Show member pathways
9.1GDF5, ESR1, BMP2, BMP7
13
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0MATK, ESR1, PTGS2
14
Show member pathways
8.7BMP7, BMP2, ESR1, PTGS2, GDF5
15
Show member pathways
8.6GDF5, PTGS2, PSMD13, BMP2, BMP7
16
Show member pathways
8.4BMP7, BMP2, MMP3, ESR1, PTGS2, GDF5

Compounds for genes affiliated with Spondylolisthesis

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Compounds related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1safranin o4310.3BMP7, MMP3
2carboxymethylcellulose4310.3BMP2, BMP7
3polyglycolic acid4310.2BMP2, BMP7
4butaprost4310.1PTGS2, MMP3
5ketorolac43 1211.1PTGS2, BMP2
6titanium4310.1BMP7, BMP2
7nimesulide43 1211.1PTGS2, MMP3
8piroxicam43 1211.1PTGS2, MMP3
9ketoprofen28 43 1212.1PTGS2, MMP3
10rofecoxib43 49 28 1213.0MMP3, PTGS2
11sulfonamide4310.0MMP3, PTGS2
12danazol43 24 1212.0ESR1, MMP3
13risedronate43 49 28 59 1214.0ESR1, PTGS2
14levonorgestrel43 59 28 1212.9MMP3, ESR1
15alginate439.9BMP7, BMP2, MMP3
16exemestane43 49 59 1212.9PTGS2, ESR1
17triptolide439.9MMP3, PTGS2
18nacl439.9BMP7, FTH1, MMP3
19glycosaminoglycan439.9GDF5, MMP3, BMP2
20tgf beta1439.9BMP7, BMP2, MMP3
21sulfasalazine28 43 49 1212.8PTGS2, MMP3
22progestins439.8PGRMC1, ESR1, MMP3
23progestin439.8MMP3, ESR1, PGRMC1
24alendronate43 49 1211.7ESR1, MMP3, BMP2
25ndga439.7PTGS2, MMP3
26leflunomide43 49 1211.7MMP3, ESR1, PTGS2
27ribonucleic acid439.7MMP3, BMP2, BMP7
28mifepristone43 28 59 1212.7MMP3, ESR1, PTGS2
29ascorbic acid43 2410.6BMP7, BMP2, FTH1, MMP3
30etanercept43 49 1211.6MMP3, PTGS2
31resveratrol43 59 24 1212.6BMP2, ESR1, PTGS2
32indomethacin43 28 59 1212.5BMP2, MMP3, PTGS2
33iron43 2410.5PTGS2, PGRMC1, MMP3, FTH1
34pge2439.5PTGS2, MMP3, BMP2, BMP7
35vitamin d439.5ESR1, MMP3, BMP2, BMP7
36sb 20358043 5910.4BMP2, MMP3, PTGS2
37pd 98,059439.3BMP2, MMP3, PTGS2
38dexamethasone43 49 28 1212.3BMP7, BMP2, MMP3, PTGS2
39genistein43 28 59 2 24 1214.3BMP2, MMP3, ESR1, PTGS2
40oxygen43 2410.2BMP7, BMP2, FTH1, MMP3, PTGS2
41progesterone43 28 59 24 1213.2BMP7, BMP2, MMP3, ESR1, PGRMC1
42cycloheximide439.1PTGS2, ESR1, MMP3, BMP2, BMP7
43vegf439.0PTGS2, ESR1, MMP3, BMP2, BMP7
44steroid438.8PGRMC1, ESR1, BMP2, LSS
45estrogen438.8PTGS2, PGRMC1, ESR1, MMP3, BMP2, BMP7
46tyrosine438.3GDF5, MMP3, BMP2, BMP7, MATK

GO Terms for genes affiliated with Spondylolisthesis

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Biological processes related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1mesenchyme developmentGO:006048510.2BMP2, BMP7
2mesenchymal cell differentiationGO:004876210.1BMP2, BMP7
3SMAD protein signal transductionGO:006039510.1BMP2, BMP7
4response to vitamin DGO:003328010.0PTGS2, BMP7
5positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.0BMP2, BMP7
6regulation of branching involved in prostate gland morphogenesisGO:006068710.0BMP7, ESR1
7positive regulation of bone mineralizationGO:003050110.0BMP2, BMP7
8growthGO:00400079.9BMP2, GDF5, BMP7
9positive regulation of neuron differentiationGO:00456669.9GDF5, BMP7, BMP2
10epithelial to mesenchymal transitionGO:00018379.9BMP2, BMP7
11bone mineralizationGO:00302829.8BMP2, PTGS2
12positive regulation of nitric oxide biosynthetic processGO:00454299.8ESR1, PTGS2
13negative regulation of cell cycleGO:00457869.8BMP7, BMP2, PTGS2
14chondrocyte differentiationGO:00020629.7BMP2, GDF5
15embryonic limb morphogenesisGO:00303269.6BMP7, GDF5
16response to estradiolGO:00323559.6PTGS2, ESR1, BMP7
17extracellular matrix organizationGO:00301989.5BMP7, GDF5, MMP3, BMP2
18positive regulation of apoptotic processGO:00430659.4BMP7, BMP2, PTGS2

Molecular functions related to Spondylolisthesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.7ESR1, PGRMC1
2growth factor activityGO:00080839.5GDF5, BMP2, BMP7
3cytokine activityGO:00051259.3BMP7, BMP2, GDF5
4protein bindingGO:00055157.1MATK, GDF5, AMIGO2, PGRMC1, ESR1, TSSK4

Products for genes affiliated with Spondylolisthesis

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Sources for Spondylolisthesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet