MCID: SPN029
MIFTS: 33

Spondylolysis malady

Bone diseases category
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Summaries for Spondylolysis

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Wikipedia:65 Spondylolysis is a defect of a vertebra. More specifically it is defined as a defect in the pars... more...

MalaCards based summary: Spondylolysis is related to spondylolisthesis and cervicitis. An important gene associated with Spondylolysis is BMP7 (bone morphogenetic protein 7), and among its related pathways is PAK Pathway. The drug baclofen and the compound glucose have been mentioned in the context of this disorder. Affiliated tissues include lumbar vertebral column, bone and testes.

Disease Ontology:8 A bone structure disease that involves a defect located in lumbar vertebral column.

Aliases & Classifications for Spondylolysis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 25ICD10
See all sources

Spondylolysis, Aliases & Descriptions:

Name: Spondylolysis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:2300
MeSH34 D013169
NCIt39 C35034
ICD1025 M43.0

Related Diseases for Spondylolysis

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Diseases related to Spondylolysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 26)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis11.0
2cervicitis10.7
3back pain10.6
4spina bifida10.3
5spina bifida occulta10.3
6osteopetrosis10.2
7radiculopathy10.2
8osteogenesis imperfecta10.2
9diabetes mellitus10.2BMP7
10syringomyelia10.1
11chiari malformation10.1
12lumbar disc herniation10.1
13ankylosing spondylitis10.0
14cerebral palsy10.0
15spondylosis10.0
16scheuermann's disease10.0
17pycnodysostosis10.0
18discitis10.0
19epidural abscess10.0
20cerebritis10.0
21aortic aneurysm10.0
22spondylitis10.0
23adolescent idiopathic scoliosis10.0
24myelomeningocele10.0
25aneurysm10.0
26chondrosarcoma9.7BMP7, FUS

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to spondylolysis

Symptoms for Spondylolysis

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Drugs & Therapeutics for Spondylolysis

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Drug clinical trials:

Search ClinicalTrials for Spondylolysis

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Spondylolysis

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Anatomical Context for Spondylolysis

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MalaCards organs/tissues related to Spondylolysis:

32
Bone, Testes

FMA organs/tissues related to Spondylolysis:

14
Lumbar vertebral column

Animal Models for Spondylolysis or affiliated genes

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Publications for Spondylolysis

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Articles related to Spondylolysis:

(show top 50)    (show all 475)
idTitleAuthorsYear
1
Characteristics of Low Back Pain in Adolescent Patients with Early-stage Spondylolysis Evaluated by a Detailed Visual Analog Scale. (25341981)
2014
2
A commentary on cervical spondylolysis in the contact athlete. (24851743)
2014
3
A biomechanical comparison of three spondylolysis repair techniques in a calf spine model. (23270724)
2013
4
Bilateral spondylolysis of inferior articular processes of the fourth lumbar vertebra: a case report. (22111522)
2012
5
Spondylolysis in the adolescent athlete. (21150440)
2011
6
Radiographic comparison between male and female patients with lumbar spondylolysis. (20299752)
2010
7
Return to sports activity by athletes after treatment of spondylolysis. (22474624)
2010
8
Cervical spondylolysis: three cases and a review of the current literature. (20075773)
2010
9
Chiropractic management of mechanical low back pain secondary to multiple-level lumbar spondylolysis with spondylolisthesis in a United States Marine Corps veteran: a case report. (19703668)
2009
10
Newly occurred L4 spondylolysis in the lumbar spine with pre-existence L5 spondylolysis among sports players: case reports and biomechanical analysis. (19084979)
2009
11
Radiographic assessment of lumbar facet distance spacing and pediatric spondylolysis. (19179924)
2009
12
Progression of spondylolysis to isthmic spondylolisthesis in an adult without accompanying disc degeneration: a case report. (18411618)
2008
13
Biomechanical and clinical study on screw hook fixation after direct repair of lumbar spondylolysis. (17026861)
2006
14
Unilateral spondylolysis combined with contralateral lumbar pediculolysis in a military parachutist. (16462222)
2006
15
Scoliosis research society outcome instrument in evaluation of long-term surgical results in spondylolysis and low-grade isthmic spondylolisthesis in young patients. (15682016)
2005
16
Magnetic resonance imaging in diagnosis and follow-up of impending spondylolysis in children and adolescents: early treatment may prevent pars defects. (15703512)
2005
17
Traumatic spondylolysis in a heptathlete: a case history and review. (19674651)
2005
18
Spondylolysis and spondylolisthesis in the child and adolescent athlete. (12974495)
2003
19
Direct stabilization of lumbar spondylolysis with a hook screw: mean 11-year follow-up period for 113 patients. (12567027)
2003
20
Isthmic spondylolisthesis and spondylolysis. (12132828)
2001
21
Disc degeneration in patients with lumbar spondylolysis. (11132978)
2000
22
SPECT in the management of patients with back pain and spondylolysis. (10656640)
2000
23
Biomechanical comparison of spondylolysis fixation techniques. (10065515)
1999
24
Management of spondylolysis and spondylolisthesis in the pediatric and adolescent population. (10393770)
1999
25
Spondylolysis at three sites in the same lumbar vertebra. (10090464)
1999
26
Retrodural cysts bridging a bilateral lumbar spondylolysis: a report of two symptomatic cases. (10433280)
1999
27
Spondylolysis of the axis vertebra: a rare anomaly simulating hangman's fracture. (9930829)
1999
28
Histomorphic analysis of the development of the pars interarticularis and its association with isthmic spondylolysis. (9704368)
1998
29
Chronic lumbar epidural hematoma in a patient who had spondylolysis at the third lumbar vertebra. Report of a rare case involving a seventeen-year-old adolescent. (9801220)
1998
30
Evaluation of specific stabilizing exercise in the treatment of chronic low back pain with radiologic diagnosis of spondylolysis or spondylolisthesis. (9431633)
1997
31
Lumbar spondylolysis: reactive marrow changes seen in adjacent pedicles on MR images. (7839983)
1995
32
Symptomatic lumbar spondylolysis. Neuroimmunologic studies. (7899974)
1994
33
SPECT evaluation of lumbar spondylolysis and spondylolisthesis. (8184357)
1994
34
Direct repair of lumbar spondylolysis. 10-year follow-up of 12 previously reported cases. (8154293)
1994
35
Posterior dislocation of the neural arch of L5 due to spondylolysis. (1749486)
1991
36
Spondylolysis and spondylolisthesis in military parachutists. (1780073)
1991
37
Treatment of spondylolysis and spondylolisthesis with Cotrel-Dubousset instrumentation: a preliminary report. (1839776)
1991
38
Cervical spondylolysis. (1781861)
1991
39
Congenital fusion C0-C2 associated with spondylolysis of C2. (2134459)
1990
40
Cervical spondylolysis: imaging findings in 12 patients. (2107670)
1990
41
Bone scintigraphy in symptomatic spondylolysis. (2953729)
1987
42
"Incomplete ring" sign: a simple method for CT detection of spondylolysis. (4019830)
1985
43
Direct repair of lumbar spondylolysis. (4072656)
1985
44
Spondylarthrography: the demonstration of spondylolysis by apophyseal joint arthrography. (4064536)
1985
45
Scoliosis in young men with spondylolysis or spondylolisthesis. A comparative study in symptomatic and asymptomatic subjects. (6495008)
1984
46
Upper lumbar spondylolysis: report of two cases. (6438551)
1984
47
Spondylolysis and spondylolisthesis in children. (6546062)
1983
48
Spondylolysis and spondylolisthesis. (544183)
1979
49
Spondylolysis. A skeletal investigation of two population groups. (361744)
1978
50
Spondylolisthesis without spondylolysis; degenerative changes in the apophyseal joints associated with subluxation in the lumbar spine. (13486340)
1957

Variations for Spondylolysis

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Expression for genes affiliated with Spondylolysis

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Expression patterns in normal tissues for genes affiliated with Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Pathways for genes affiliated with Spondylolysis

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Pathways related to Spondylolysis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3BMP7, PTPRN2

Compounds for genes affiliated with Spondylolysis

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Sources:
44Novoseek
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Compounds related to Spondylolysis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glucose449.3BMP7, PTPRN2

GO Terms for genes affiliated with Spondylolysis

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Products for genes affiliated with Spondylolysis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Spondylolysis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet