MCID: SPN029
MIFTS: 32

Spondylolysis malady

Bone diseases category

Summaries for Spondylolysis

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Spondylolysis is a defect of a vertebra. More specifically it is defined as a defect in the pars... more...

MalaCards: Spondylolysis is related to spondylolisthesis and cervicitis. An important gene associated with Spondylolysis is BMP7 (bone morphogenetic protein 7), and among its related pathways is PAK Pathway. The drug baclofen and the compound glucose have been mentioned in the context of this disorder. Affiliated tissues include lumbar vertebral column, bone and testes.

Disease Ontology:9 A bone structure disease that involves a defect located in lumbar vertebral column.

Aliases & Classifications for Spondylolysis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

spondylolysis 9 11 46 63


External Ids:

Disease Ontology9 DOID:2300
MeSH36 D013169
NCIt41 C35034
ICD1026 M43.0

Related Diseases for Spondylolysis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Spondylolysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 24)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis11.0
2cervicitis10.7
3back pain10.5
4radiculopathy10.2
5osteogenesis imperfecta10.2
6syringomyelia10.1
7osteopetrosis10.1
8spina bifida10.1
9chiari malformation10.1
10spina bifida occulta10.1
11diabetes mellitus10.0BMP7
12ankylosing spondylitis10.0
13discitis10.0
14spondylosis10.0
15epidural abscess10.0
16cerebritis10.0
17pycnodysostosis10.0
18scheuermann's disease10.0
19aortic aneurysm10.0
20cerebral palsy10.0
21spondylitis10.0
22aneurysm10.0
23lumbar disc herniation10.0
24chondrosarcoma9.9BMP7, FUS

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to spondylolysis

Symptoms for Spondylolysis

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Drugs & Therapeutics for Spondylolysis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Spondylolysis

Drug clinical trials:

Search ClinicalTrials for Spondylolysis

Search NIH Clinical Center for Spondylolysis

Search CenterWatch for Spondylolysis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Spondylolysis

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Anatomical Context for Spondylolysis

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Spondylolysis:

34
Bone, Testes

FMA organs/tissues related to Spondylolysis:

15
Lumbar vertebral column

Animal Models for Spondylolysis or affiliated genes

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Publications for Spondylolysis

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53PubMed
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Articles related to Spondylolysis:

(show top 50)    (show all 460)
idTitleAuthorsYear
1
A biomechanical comparison of three spondylolysis repair techniques in a calf spine model. (23270724)
2013
2
Bilateral spondylolysis of inferior articular processes of the fourth lumbar vertebra: a case report. (22111522)
2012
3
Spondylolysis in the adolescent athlete. (21150440)
2011
4
Radiographic comparison between male and female patients with lumbar spondylolysis. (20299752)
2010
5
Return to sports activity by athletes after treatment of spondylolysis. (22474624)
2010
6
Cervical spondylolysis: three cases and a review of the current literature. (20075773)
2010
7
Chiropractic management of mechanical low back pain secondary to multiple-level lumbar spondylolysis with spondylolisthesis in a United States Marine Corps veteran: a case report. (19703668)
2009
8
Newly occurred L4 spondylolysis in the lumbar spine with pre-existence L5 spondylolysis among sports players: case reports and biomechanical analysis. (19084979)
2009
9
Radiographic assessment of lumbar facet distance spacing and pediatric spondylolysis. (19179924)
2009
10
Progression of spondylolysis to isthmic spondylolisthesis in an adult without accompanying disc degeneration: a case report. (18411618)
2008
11
Biomechanical and clinical study on screw hook fixation after direct repair of lumbar spondylolysis. (17026861)
2006
12
Unilateral spondylolysis combined with contralateral lumbar pediculolysis in a military parachutist. (16462222)
2006
13
Assessment of bony union following surgical stabilisation for lumbar spondylolysis: a comparative study between radiography and computed tomography. (16914796)
2006
14
Scoliosis research society outcome instrument in evaluation of long-term surgical results in spondylolysis and low-grade isthmic spondylolisthesis in young patients. (15682016)
2005
15
Magnetic resonance imaging in diagnosis and follow-up of impending spondylolysis in children and adolescents: early treatment may prevent pars defects. (15703512)
2005
16
Traumatic spondylolysis in a heptathlete: a case history and review. (19674651)
2005
17
Spondylolysis and spondylolisthesis in the child and adolescent athlete. (12974495)
2003
18
Direct stabilization of lumbar spondylolysis with a hook screw: mean 11-year follow-up period for 113 patients. (12567027)
2003
19
Isthmic spondylolisthesis and spondylolysis. (12132828)
2001
20
Disc degeneration in patients with lumbar spondylolysis. (11132978)
2000
21
SPECT in the management of patients with back pain and spondylolysis. (10656640)
2000
22
Biomechanical comparison of spondylolysis fixation techniques. (10065515)
1999
23
Management of spondylolysis and spondylolisthesis in the pediatric and adolescent population. (10393770)
1999
24
Spondylolysis at three sites in the same lumbar vertebra. (10090464)
1999
25
Retrodural cysts bridging a bilateral lumbar spondylolysis: a report of two symptomatic cases. (10433280)
1999
26
Spondylolysis of the axis vertebra: a rare anomaly simulating hangman's fracture. (9930829)
1999
27
Histomorphic analysis of the development of the pars interarticularis and its association with isthmic spondylolysis. (9704368)
1998
28
Chronic lumbar epidural hematoma in a patient who had spondylolysis at the third lumbar vertebra. Report of a rare case involving a seventeen-year-old adolescent. (9801220)
1998
29
Evaluation of specific stabilizing exercise in the treatment of chronic low back pain with radiologic diagnosis of spondylolysis or spondylolisthesis. (9431633)
1997
30
Lumbar spondylolysis: reactive marrow changes seen in adjacent pedicles on MR images. (7839983)
1995
31
Symptomatic lumbar spondylolysis. Neuroimmunologic studies. (7899974)
1994
32
SPECT evaluation of lumbar spondylolysis and spondylolisthesis. (8184357)
1994
33
Direct repair of lumbar spondylolysis. 10-year follow-up of 12 previously reported cases. (8154293)
1994
34
Posterior dislocation of the neural arch of L5 due to spondylolysis. (1749486)
1991
35
Spondylolysis and spondylolisthesis in military parachutists. (1780073)
1991
36
Treatment of spondylolysis and spondylolisthesis with Cotrel-Dubousset instrumentation: a preliminary report. (1839776)
1991
37
Cervical spondylolysis. (1781861)
1991
38
Congenital fusion C0-C2 associated with spondylolysis of C2. (2134459)
1990
39
Cervical spondylolysis: imaging findings in 12 patients. (2107670)
1990
40
Bone scintigraphy in symptomatic spondylolysis. (2953729)
1987
41
"Incomplete ring" sign: a simple method for CT detection of spondylolysis. (4019830)
1985
42
Direct repair of lumbar spondylolysis. (4072656)
1985
43
Spondylarthrography: the demonstration of spondylolysis by apophyseal joint arthrography. (4064536)
1985
44
Scoliosis in young men with spondylolysis or spondylolisthesis. A comparative study in symptomatic and asymptomatic subjects. (6495008)
1984
45
Upper lumbar spondylolysis: report of two cases. (6438551)
1984
46
Spondylolysis and spondylolisthesis in children. (6546062)
1983
47
Spondylolysis and spondylolisthesis. (544183)
1979
48
Spondylolysis. A skeletal investigation of two population groups. (361744)
1978
49
Spondylolysis following trauma: a case report. (5687797)
1968
50
Spondylolisthesis without spondylolysis; degenerative changes in the apophyseal joints associated with subluxation in the lumbar spine. (13486340)
1957

Variations for Spondylolysis

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Expression for genes affiliated with Spondylolysis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Pathways for genes affiliated with Spondylolysis

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51PathCards, 54QIAGEN
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Pathways related to Spondylolysis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3BMP7, PTPRN2

Compounds for genes affiliated with Spondylolysis

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46Novoseek
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Compounds related to Spondylolysis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glucose469.3BMP7, PTPRN2

GO Terms for genes affiliated with Spondylolysis

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Products for genes affiliated with Spondylolysis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylolysis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet