Aliases & Classifications for Spondylolysis

MalaCards integrated aliases for Spondylolysis:

Name: Spondylolysis 12 28 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2300
ICD10 32 M43.0 M43.00
MeSH 41 D013169
NCIt 46 C35034
SNOMED-CT 64 203688008 240221008
UMLS 69 C0038018

Summaries for Spondylolysis

Disease Ontology : 12 A bone structure disease that involves a defect located in lumbar vertebral column.

MalaCards based summary : Spondylolysis is related to spondylolisthesis and cervicitis, and has symptoms including back pain An important gene associated with Spondylolysis is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Glucose / Energy Metabolism and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ketamine and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include lumbar vertebral column, bone and testes.

Wikipedia : 72 Spondylolysis (spon-dee-low-lye-sis) is defined as a defect or stress fracture in the pars... more...

Related Diseases for Spondylolysis

Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 31.6 BMP7 FTH1 GDF5
2 cervicitis 10.5
3 episodic pain syndrome, familial, 1 10.4
4 back pain 10.3
5 scoliosis 10.1
6 neural tube defects 10.0
7 aging 10.0
8 spina bifida occulta 10.0
9 brittle bone disorder 9.9
10 osteopetrosis 9.9
11 radiculopathy 9.9
12 idiopathic scoliosis 9.9
13 syringomyelia 9.9
14 chiari malformation 9.9
15 spondyloarthropathy 1 9.7
16 polydactyly, postaxial, with progressive myopia 9.7
17 scheuermann disease 9.7
18 scoliosis, isolated 1 9.7
19 diastematomyelia 9.7
20 diastrophic dysplasia 9.7
21 osteoid osteoma 9.7
22 pycnodysostosis 9.7
23 cerebral palsy 9.7
24 osteoarthritis 9.7
25 spinal stenosis 9.7
26 myelomeningocele 9.7
27 discitis 9.7
28 epidural abscess 9.7
29 inflammatory spondylopathy 9.7
30 spondylosis 9.7
31 cerebritis 9.7
32 aortic aneurysm 9.7
33 spondylitis 9.7
34 aneurysm 9.7
35 proximal symphalangism 9.7 BMP7 GDF5
36 bone deterioration disease 9.6 BMP7 FTH1 GDF5
37 bone structure disease 9.5 BMP7 FTH1 GDF5

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to Spondylolysis

Symptoms & Phenotypes for Spondylolysis

UMLS symptoms related to Spondylolysis:


back pain

Drugs & Therapeutics for Spondylolysis

Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
2
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
3
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
4
Menthol Approved Phase 4 2216-51-5 16666
5 Analgesics Phase 4,Phase 2,Phase 3
6 Analgesics, Opioid Phase 4
7 Anesthetics Phase 4,Phase 2,Phase 3
8 Anesthetics, Dissociative Phase 4
9 Anesthetics, General Phase 4
10 Anesthetics, Intravenous Phase 4
11 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
12 Excitatory Amino Acid Antagonists Phase 4
13 Excitatory Amino Acids Phase 4
14 Narcotics Phase 4
15 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
16 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
17 Anti-Anxiety Agents Phase 4
18 Anticonvulsants Phase 4
19 calcium channel blockers Phase 4
20 Calcium, Dietary Phase 4
21 Psychotropic Drugs Phase 4
22 Tranquilizing Agents Phase 4
23
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
24 Adrenergic Agents Phase 2, Phase 3
25 Adrenergic Agonists Phase 2, Phase 3
26 Adrenergic alpha-2 Receptor Agonists Phase 2, Phase 3
27 Adrenergic alpha-Agonists Phase 2, Phase 3
28 Analgesics, Non-Narcotic Phase 2, Phase 3
29 Hypnotics and Sedatives Phase 2, Phase 3
30 Cisatracurium Approved, Experimental Phase 2 96946-41-7
31
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
32
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
33
Remifentanil Approved Phase 2 132875-61-7 60815
34
Ropivacaine Approved Phase 2 84057-95-4 175805 71273
35
s 1 (combination) Phase 1, Phase 2
36 Anesthetics, Local Phase 2
37 BB 1101 Phase 2
38 Dexamethasone acetate Phase 2 1177-87-3
39
Teriparatide Approved, Investigational 52232-67-4 16133850
40
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
41
Silicon Approved, Investigational 7440-21-3 4082203
42
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
43
Epinephrine Approved, Vet_approved 51-43-4 5816
44
Ketorolac Approved 74103-06-3, 66635-83-4 3826
45
Lidocaine Approved, Vet_approved 137-58-6 3676
46
Morphine Approved, Investigational 57-27-2 5288826
47 Racepinephrine Approved 329-65-7
48
Gabapentin Approved, Investigational 60142-96-3 3446
49
Dimenhydrinate Approved 523-87-5 441281
50 tannic acid Approved, Nutraceutical

Interventional clinical trials:

(show top 50) (show all 117)

# Name Status NCT ID Phase Drugs
1 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
2 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
3 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
4 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
5 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
6 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
7 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
8 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
9 Aspen Spinous Process Fixation System for Use in PLF in Patients With Spondylolisthesis Terminated NCT01560273 Phase 4
10 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
11 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
12 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
13 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
14 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
15 Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion Recruiting NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
16 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
17 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
18 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
19 Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion Completed NCT01106417 Phase 2
20 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy Completed NCT01097486 Phase 2
21 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Completed NCT00996073 Phase 2
22 Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) Completed NCT00549913 Phase 1, Phase 2
23 Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis Recruiting NCT03100032 Phase 1, Phase 2
24 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery Recruiting NCT02884440 Phase 2 TAP block ropivacaine;TAP block placebo;General anesthesia
25 Safety Study of Mesenchymal Stem Cells and Spinal Fusion Active, not recruiting NCT01552707 Phase 1, Phase 2
26 CopiOs Posterolateral Fusion Procedure Terminated NCT01123850 Phase 2
27 Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion Withdrawn NCT00810212 Phase 1, Phase 2
28 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379
29 Clinical Evaluation of GENEX® DS in Instrumented Posterolateral Fusion Unknown status NCT02317185
30 Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures Unknown status NCT02171169
31 Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion Unknown status NCT01292252
32 Dynesys Spinal System Post Market 522 Study Unknown status NCT01528072
33 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain Unknown status NCT01918943
34 Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression Unknown status NCT01338766
35 Prospective Study of Minimally Invasive Spine Surgery Unknown status NCT01045473
36 Direct Repair Surgery for Spondylolysis of Lumbar in Young Population Completed NCT02129374
37 The Addition of a Pilates Program for Short-Term Improvements in Patients With Spondylolysis or Spondylolisthesis Completed NCT01711203
38 Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease Completed NCT02070484
39 New Robotic Assistance System for Spinal Fusion Surgery Completed NCT02558621
40 Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Fusions Completed NCT00555659
41 Free Hand Lumbar Pedicular Screw Fixation Completed NCT03327298
42 Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP Trial Completed NCT01557829
43 Multimodal Perioperative Pain Management Completed NCT01513564 Postoperative epidural morphine;Local anaesthesia
44 XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Central Stenosis. Completed NCT01024699
45 SPONGIT: Comparison of Two Surgical Approaches in the Treatment of Degenerative Spondylolysthesis Completed NCT00869882
46 Spinal Fusion and Rehabilitation Study Completed NCT00834015
47 Posterior Lateral Fusion (PLF) With Dynesys Completed NCT00791180
48 A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions Completed NCT00679107
49 Study of OP-1 Putty in Uninstrumented Posterolateral Fusions Completed NCT00678353
50 OP-1 Putty for Posterolateral Fusions Completed NCT00677950

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: spondylolysis

Genetic Tests for Spondylolysis

Genetic tests related to Spondylolysis:

# Genetic test Affiliating Genes
1 Spondylolysis 28

Anatomical Context for Spondylolysis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolysis:

18
Lumbar Vertebral Column

MalaCards organs/tissues related to Spondylolysis:

38
Bone, Testes, Bone Marrow

Publications for Spondylolysis

Articles related to Spondylolysis:

(show top 50) (show all 554)
# Title Authors Year
1
Efficacy and outcome predictors of fluoroscopy-guided facet joint injection for spondylolysis. ( 29396693 )
2018
2
Imaging of Spondylolysis: The Evolving Role of Magnetic Resonance Imaging. ( 29428876 )
2018
3
A comparison of the techniques of direct pars interarticularis repairs for spondylolysis and low-grade spondylolisthesis: a meta-analysis. ( 29290131 )
2018
4
Multilevel Spondylolysis Repair Using the "Smiley Face" Technique with 3-Dimensional Intraoperative Spinal Navigation. ( 29054782 )
2018
5
Vertebral body bone mineral density in patients with lumbar spondylolysis: a quantitative CT study. ( 28765098 )
2017
6
Headless compression screw in the neuronavigation-guided and microscope-assisted treatment of spondylolysis. ( 28988667 )
2017
7
Different fusion approaches for single-level lumbar spondylolysis have similar perioperative outcomes. ( 28591074 )
2017
8
Properties of Paraspinal Muscles in Japanese High School Baseball Players With Terminal-Stage Lumbar Spondylolysis. ( 28673735 )
2017
9
Degenerative Changes of the Facet Joints in Adults With Lumbar Spondylolysis. ( 28632562 )
2017
10
Lumbar Spondylolysis And Spondylolisthesis ( 28846329 )
2017
11
Benign Natural History of Spondylolysis in Adolescence With Midterm Follow-Up. ( 28259265 )
2017
12
Indirect pars repair for pediatric isthmic spondylolysis: a case series. ( 29057347 )
2017
13
The Relationship Between Sacral Slope and Symptomatic IsthmicA Spondylolysis in a Cohort of High School Athletes: A Retrospective Analysis. ( 28993288 )
2017
14
Current Evidence Regarding Diagnostic Imaging Methods for Pediatric Lumbar Spondylolysis: A Report From the Scoliosis Research Society Evidence-Based Medicine Committee. ( 28259272 )
2017
15
Low-Intensity Pulsed Ultrasound for Early-Stage Lumbar Spondylolysis in Young Athletes. ( 29035987 )
2017
16
The prevalence of lumbar spondylolysis in young children: a retrospective analysis using CT. ( 29030702 )
2017
17
Prevalence of Spondylolysis in Symptomatic Adolescent Athletes: An Assessment of Sport Risk in Nonelite Athletes. ( 29140811 )
2017
18
Minimally-Invasive versus Conventional Repair of Spondylolysis in Athletes: A Review of Outcomes and Return to Play. ( 29093794 )
2017
19
Does the Prevalence of Spondylolysis and Spina Bifida Occulta Observed in Pediatric Patients Remain Stable in Adults? ( 28937467 )
2017
20
Adolescent Spondylolysis: Management and Return to Play. ( 28594517 )
2017
21
Low-intensity pulsed ultrasound is effective for progressive-stage lumbar spondylolysis with MRI high-signal change. ( 28391380 )
2017
22
Spondylolysis in the past: A case study of hunter-gatherers from Southern Patagonia. ( 29198391 )
2017
23
Lumbar spondylolysis: A report of four cases from two generations of a family. ( 28617180 )
2017
24
Pediatric spondylolysis/spinal stenosis and disc herniation: national trends in decompression and discectomy surgery evaluated through the Kids' Inpatient Database. ( 28643037 )
2017
25
Contralateral Spondylolysis and Fracture of the Lumbar Pedicle in a Young Athlete. ( 28542108 )
2017
26
Active stretching for lower extremity muscle tightness in pediatric patients with lumbar spondylolysis. ( 28373610 )
2017
27
Increased Lumbar Lordosis and Smaller Vertebral Cross-sectional Area are Associated with Spondylolysis. ( 29095410 )
2017
28
Congenital double-level cervical spondylolysis: a case report and review of the literature. ( 28247078 )
2017
29
A minimal soft tissue damage approach of spondylolysis repair in athletes: preliminary report. ( 28497280 )
2017
30
Spondylolisthesis with spondylolysis in a 17-month-old: a case report. ( 29354748 )
2017
31
Lumbar Back Pain Secondary to Spondylolysis. ( 28471908 )
2017
32
Posterior Dynamic Stabilization With Direct Pars Repair via Wiltse Approach for the Treatment of Lumbar Spondylolysis: The Application of a Novel Surgery. ( 26630436 )
2016
33
Prevalence of Symptomatic Lumbar Spondylolysis in Pediatric Patients. ( 27064777 )
2016
34
Conservative Treatment for Bony Healing in Pediatric Lumbar Spondylolysis. ( 27755499 )
2016
35
Differences of Sagittal Lumbosacral Parameters between Patients with Lumbar Spondylolysis and Normal Adults. ( 27174324 )
2016
36
Short and Long Term Outcomes in Acute versus Chronic Lumbar Spondylolysis in Adolescents Athletes: 1858 Board #10 June 2, 2: 00 PM - 3: 30 PM. ( 27360683 )
2016
37
Timing of Physical Therapy Referral in Adolescent Athletes With Acute Spondylolysis: A Retrospective Chart Review. ( 27347866 )
2016
38
Athletic Population with Spondylolysis: Review of Outcomes following Surgical Repair or Conservative Management. ( 27556003 )
2016
39
Diagnostic utility of patient history and physical examination data to detect spondylolysis and spondylolisthesis in athletes with low back pain: A systematic review. ( 27317501 )
2016
40
Spondylolysis and End Plate Arthrosis at L5-S1: A Cadaveric Study. ( 27684084 )
2016
41
Poster 189 Multilevel Spondylolysis in An Adolescent Athlete: AA Case Report. ( 27672955 )
2016
42
Confidence in Assessment of Lumbar Spondylolysis Using Three-Dimensional Volumetric T2-Weighted MRI Compared With Limited Field of View, Decreased-Dose CT. ( 27282808 )
2016
43
A Novel Motion-Preservation Technique for Intra and Intra-Intersegmental Repair of Spondylolysis and Spondylolisthesis: The Lin Technique. ( 27608745 )
2016
44
Is Preventative Long-Segment Surgery for Multi-Level Spondylolysis Necessary? A Finite Element Analysis Study. ( 26918333 )
2016
45
Imaging Pediatric Spondylolysis: A Systematic Review. ( 27669047 )
2016
46
Lumbar spondylolysis in the adolescent athlete. ( 27234265 )
2016
47
Classification of spondylolytic clefts in patients with spondylolysis or isthmic spondylolisthesis using positional MRI. ( 26987671 )
2016
48
Long-Term Clinical Outcomes and Factors That Predict Poor Prognosis in Athletes After a Diagnosis of Acute Spondylolysis: A Retrospective Review With Telephone Follow-up. ( 27825292 )
2016
49
Review of Pediatric Spondylolysis and Spondylolisthesis. ( 27811518 )
2016
50
Sacral Stress Fracture following the Bone Union of Lumbar Spondylolysis. ( 28050170 )
2016

Variations for Spondylolysis

Expression for Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Pathways for Spondylolysis

Pathways related to Spondylolysis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.61 FTH1 PGRMC1 SLC7A11
2 11.3 BMP7 GDF5
3 11.18 BMP7 GDF5
4
Show member pathways
11.02 BMP7 GDF5
5 10.23 FTH1 SLC7A11

GO Terms for Spondylolysis

Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.4 BMP7 SLC26A2
2 positive regulation of neuron differentiation GO:0045666 9.37 BMP7 GDF5
3 cartilage development GO:0051216 9.32 BMP7 GDF5
4 SMAD protein signal transduction GO:0060395 9.26 BMP7 GDF5
5 embryonic limb morphogenesis GO:0030326 9.16 BMP7 GDF5
6 cell development GO:0048468 8.96 BMP7 GDF5
7 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 8.62 BMP7 GDF5

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP7 GDF5

Sources for Spondylolysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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