Spondylolysis malady

Wikipedia: Spondylolysis is a defect of a vertebra. More specifically it is defined as a defect in the pars...⁴⁴ more...

MalaCards: Spondylolysis is related to spondylolisthesis. An important gene associated with Spondylolysis is BMP7 (bone morphogenetic protein 7), and among its related pathways is Processing of Capped Intron-Containing Pre-mRNA. The drug baclofen has been mentioned in the context of this disorder. Affiliated tissues include lumbar vertebral column.

Disease Ontology: A bone structure disease that involves a defect located in lumbar vertebral column.⁶

Aliases & Descriptions:

spondylolysis 6 8 32 43

Diseases related to spondylolysis by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	spondylolisthesis	12.8	BMP7, PGRMC1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 baclofen

FMA organs/tissues related to spondylolysis:

¹¹

Genes related to spondylolysis according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	BMP7	bone morphogenetic protein 7	11.0	Disorders
2	KNCN	kinocilin	11.0
3	ZBTB8OS	zinc finger and BTB domain containing 8 opposite strand	11.0
4	CD2BP2	CD2 (cytoplasmic tail) binding protein 2	11.0	Disorders
5	MED6	mediator complex subunit 6	11.0
6	PGRMC1	progesterone receptor membrane component 1	11.0	Disorders
7	PARP14	poly (ADP-ribose) polymerase family, member 14	11.0	Disorders
8	MRPL13	mitochondrial ribosomal protein L13	11.0
9	FAM60A	family with sequence similarity 60, member A	11.0	Disorders
10	FUS	fused in sarcoma	11.0	Disorders
11	PTPRN2	protein tyrosine phosphatase, receptor type, N polypeptide 2	11.0	Disorders

Pathways related to spondylolysis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Processing of Capped Intron-Containing Pre-mRNA38	9.3	FUS, CD2BP2