Aliases & Classifications for Spondylolysis

Aliases & Descriptions for Spondylolysis:

Name: Spondylolysis 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2300
ICD10 33 M43.0 M43.00
MeSH 42 D013169
NCIt 47 C35034
SNOMED-CT 64 203688008 240221008
UMLS 69 C0038018

Summaries for Spondylolysis

Disease Ontology : 12 A bone structure disease that involves a defect located in lumbar vertebral column.

MalaCards based summary : Spondylolysis is related to spondylolisthesis and cervicitis, and has symptoms including back pain An important gene associated with Spondylolysis is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Glucose / Energy Metabolism and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ketamine and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lumbar vertebral column.

Wikipedia : 71 Spondylolysis (spon-dee-low-lye-sis) is defined as a defect or stress fracture in the pars... more...

Related Diseases for Spondylolysis

Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
id Related Disease Score Top Affiliating Genes
1 spondylolisthesis 10.7
2 cervicitis 10.4
3 back pain 10.2
4 bone structure disease 10.0 GDF5 SLC26A2
5 scoliosis 10.0
6 tarsal-carpal coalition syndrome 10.0 BMP7 GDF5
7 spina bifida occulta 9.9
8 multiple synostoses syndrome 9.9 BMP7 GDF5
9 radiculopathy 9.9
10 osteopetrosis 9.9
11 osteogenesis imperfecta 9.9
12 bone resorption disease 9.8 BMP7 FTH1 GDF5
13 physical disorder 9.8 BMP7 FTH1 GDF5
14 chiari malformation 9.8
15 idiopathic scoliosis 9.8
16 syringomyelia 9.8
17 systemic scleroderma 9.7 BMP7 FTH1 GDF5 PGRMC1
18 diastematomyelia 9.6
19 cerebral palsy 9.6
20 spondylitis 9.6
21 adolescent idiopathic scoliosis 9.6
22 aneurysm 9.6
23 myelomeningocele 9.6
24 discitis 9.6
25 epidural abscess 9.6
26 spondylosis 9.6
27 pycnodysostosis 9.6
28 cerebritis 9.6
29 diastrophic dysplasia 9.6
30 aortic aneurysm 9.6
31 nocardiosis 9.0 BMP7 FTH1 FUS GDF5 PGRMC1 SLC26A2

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to Spondylolysis

Symptoms & Phenotypes for Spondylolysis

UMLS symptoms related to Spondylolysis:


back pain

Drugs & Therapeutics for Spondylolysis

Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
2
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
3
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
4 Analgesics Phase 4,Phase 2,Phase 3
5 Analgesics, Opioid Phase 4
6 Anesthetics Phase 4,Phase 2,Phase 3
7 Anesthetics, Dissociative Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Intravenous Phase 4
10 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
11 Excitatory Amino Acid Antagonists Phase 4
12 Excitatory Amino Acids Phase 4
13 Narcotics Phase 4
14 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
15 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
16
s 1 (combination) Phase 4,Phase 1,Phase 2
17 Anti-Anxiety Agents Phase 4
18 Anticonvulsants Phase 4
19 calcium channel blockers Phase 4
20 Calcium, Dietary Phase 4
21 Psychotropic Drugs Phase 4
22 Tranquilizing Agents Phase 4
23
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
24 Adrenergic Agents Phase 2, Phase 3
25 Adrenergic Agonists Phase 2, Phase 3
26 Adrenergic alpha-2 Receptor Agonists Phase 2, Phase 3
27 Adrenergic alpha-Agonists Phase 2, Phase 3
28 Analgesics, Non-Narcotic Phase 2, Phase 3
29 Hypnotics and Sedatives Phase 2, Phase 3
30
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
31
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
32
Remifentanil Approved Phase 2 132875-61-7 60815
33
Ropivacaine Approved Phase 2 84057-95-4 71273 175805
34 Anesthetics, Local Phase 2
35 BB 1101 Phase 2
36 Cisatracurium Phase 2
37 Dexamethasone 21-phosphate Phase 2
38 Dexamethasone acetate Phase 2 1177-87-3
39
Benzocaine Approved 1994-09-7, 94-09-7 2337
40
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
41
Epinephrine Approved, Vet_approved 51-43-4 5816
42
Ketorolac Approved 74103-06-3, 66635-83-4 3826
43
Lidocaine Approved, Vet_approved 137-58-6 3676
44
Morphine Approved, Investigational 57-27-2 5288826
45
Dimenhydrinate Approved 523-87-5 441281
46
Teriparatide Approved, Investigational 52232-67-4 16133850
47
Menthol Approved 2216-51-5 16666
48
Gabapentin Approved, Investigational 60142-96-3 3446
49 tannic acid Approved, Nutraceutical
50 Micronutrients

Interventional clinical trials:

(show top 50) (show all 105)
id Name Status NCT ID Phase
1 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
2 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4
3 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
4 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
5 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4
6 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
7 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
8 Comparison of Complication Rates Between Lateral Approaches to the Lumbar Spine Enrolling by invitation NCT02068729 Phase 4
9 Aspen Spinous Process Fixation System for Use in PLF in Patients With Spondylolisthesis Terminated NCT01560273 Phase 4
10 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
11 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
12 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
13 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
14 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
15 Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion Recruiting NCT02854904 Phase 2, Phase 3
16 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
17 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
18 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
19 Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion Completed NCT01106417 Phase 2
20 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy Completed NCT01097486 Phase 2
21 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Completed NCT00996073 Phase 2
22 Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) Completed NCT00549913 Phase 1, Phase 2
23 Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis Recruiting NCT03100032 Phase 1, Phase 2
24 Safety Study of Mesenchymal Stem Cells and Spinal Fusion Active, not recruiting NCT01552707 Phase 1, Phase 2
25 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery Not yet recruiting NCT02884440 Phase 2
26 CopiOs Posterolateral Fusion Procedure Terminated NCT01123850 Phase 2
27 Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion Withdrawn NCT00810212 Phase 1, Phase 2
28 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379
29 Clinical Evaluation of GENEX® DS in Instrumented Posterolateral Fusion Unknown status NCT02317185
30 Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures Unknown status NCT02171169
31 Effects of Exercise Intervention on Patients With Low Back Pain Due to Spondylolytic Spondylolisthesis. Unknown status NCT01985776
32 Prospective Study of Minimally Invasive Spine Surgery Unknown status NCT01045473
33 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain Unknown status NCT01918943
34 Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression Unknown status NCT01338766
35 Direct Repair Surgery for Spondylolysis of Lumbar in Young Population Completed NCT02129374
36 The Addition of a Pilates Program for Short-Term Improvements in Patients With Spondylolysis or Spondylolisthesis Completed NCT01711203
37 New Robotic Assistance System for Spinal Fusion Surgery Completed NCT02558621
38 Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Fusions Completed NCT00555659
39 Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP Trial Completed NCT01557829
40 Multimodal Perioperative Pain Management Completed NCT01513564
41 XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Central Stenosis. Completed NCT01024699
42 SPONGIT: Comparison of Two Surgical Approaches in the Treatment of Degenerative Spondylolysthesis Completed NCT00869882
43 Spinal Fusion and Rehabilitation Study Completed NCT00834015
44 Posterior Lateral Fusion (PLF) With Dynesys Completed NCT00791180
45 A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions Completed NCT00679107
46 Study of OP-1 Putty in Uninstrumented Posterolateral Fusions Completed NCT00678353
47 OP-1 Putty for Posterolateral Fusions Completed NCT00677950
48 Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion Completed NCT00205101
49 Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine Completed NCT01968993
50 Evaluation Of Spinelink® Fixation In The Treatment Of Degenerative Spondylolisthesis And Spinal Instability Completed NCT00726310

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: spondylolysis

Genetic Tests for Spondylolysis

Genetic tests related to Spondylolysis:

id Genetic test Affiliating Genes
1 Spondylolysis 29

Anatomical Context for Spondylolysis

MalaCards organs/tissues related to Spondylolysis:

39
Bone, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolysis:

18
Lumbar Vertebral Column

Publications for Spondylolysis

Articles related to Spondylolysis:

(show top 50) (show all 522)
id Title Authors Year
1
Athletic Population with Spondylolysis: Review of Outcomes following Surgical Repair or Conservative Management. ( 27556003 )
2016
2
Confidence in Assessment of Lumbar Spondylolysis Using Three-Dimensional Volumetric T2-Weighted MRI Compared With Limited Field of View, Decreased-Dose CT. ( 27282808 )
2016
3
Timing of Physical Therapy Referral in Adolescent Athletes With Acute Spondylolysis: A Retrospective Chart Review. ( 27347866 )
2016
4
Prevalence of Symptomatic Lumbar Spondylolysis in Pediatric Patients. ( 27064777 )
2016
5
Lumbar spondylolysis in the adolescent athlete. ( 27234265 )
2016
6
A Novel Motion-Preservation Technique for Intra and Intra-Intersegmental Repair of Spondylolysis and Spondylolisthesis: The Lin Technique. ( 27608745 )
2016
7
Differences of Sagittal Lumbosacral Parameters between Patients with Lumbar Spondylolysis and Normal Adults. ( 27174324 )
2016
8
Conservative Treatment for Bony Healing in Pediatric Lumbar Spondylolysis. ( 27755499 )
2016
9
Posterior Dynamic Stabilization With Direct Pars Repair via Wiltse Approach for the Treatment of Lumbar Spondylolysis: The Application of a Novel Surgery. ( 26630436 )
2016
10
Sacral Stress Fracture following the Bone Union of Lumbar Spondylolysis. ( 28050170 )
2016
11
Short and Long Term Outcomes in Acute versus Chronic Lumbar Spondylolysis in Adolescents Athletes: 1858 Board #10 June 2, 2: 00 PM - 3: 30 PM. ( 27360683 )
2016
12
Long-Term Clinical Outcomes and Factors That Predict Poor Prognosis in Athletes After a Diagnosis of Acute Spondylolysis: A Retrospective Review With Telephone Follow-up. ( 27825292 )
2016
13
Classification of spondylolytic clefts in patients with spondylolysis or isthmic spondylolisthesis using positional MRI. ( 26987671 )
2016
14
Is Preventative Long-Segment Surgery for Multi-Level Spondylolysis Necessary? A Finite Element Analysis Study. ( 26918333 )
2016
15
Review of Pediatric Spondylolysis and Spondylolisthesis. ( 27811518 )
2016
16
Poster 189 Multilevel Spondylolysis in An Adolescent Athlete: AA Case Report. ( 27672955 )
2016
17
Spondylolysis and End Plate Arthrosis at L5-S1: A Cadaveric Study. ( 27684084 )
2016
18
Imaging Pediatric Spondylolysis: A Systematic Review. ( 27669047 )
2016
19
Diagnostic utility of patient history and physical examination data to detect spondylolysis and spondylolisthesis in athletes with low back pain: A systematic review. ( 27317501 )
2016
20
Degenerative Changes of the Facet Joints in Adults with Lumbar Spondylolysis. ( 25633897 )
2015
21
Atypical, unusual, and misleading imaging presentations of spondylolysis. ( 25855410 )
2015
22
Clinical tests to diagnose lumbar spondylolysis and spondylolisthesis: A systematic review. ( 25797410 )
2015
23
Characteristics of lumbar spondylolysis in elementary school age children. ( 26006706 )
2015
24
Multilevel Thoracolumbar Spondylolysis with Spondylolisthesis at L4 on L5. ( 26330968 )
2015
25
CT outperforms radiographs at a comparable radiation dose in the assessment for spondylolysis. ( 25712453 )
2015
26
Comparison of lumbar discectomy alone and lumbar discectomy withA direct repair of pars defect for patients with disc herniation andA spondylolysis at the nearby lumbar segment. ( 26070287 )
2015
27
Treatment for spondylolysis and spondylolisthesis in children. ( 26715723 )
2015
28
The adolescent multiple spondylolysis associated with spondylolisthesis in the upper lumbar vertebrae. ( 26196105 )
2015
29
A review of the pathomechanism of forward slippage in pediatric spondylolysis: The Tokushima theory of growth plate slippage. ( 25817277 )
2015
30
Hysterical conversion paralysis in an adolescent boy with lumbar spondylolysis. ( 26049966 )
2015
31
Characteristics Associated With Active Defects in Juvenile Spondylolysis. ( 26447415 )
2015
32
The effectiveness of surgical versus conservative treatment for symptomatic unilateral spondylolysis of the lumbar spine in athletes: a systematic review. ( 26447055 )
2015
33
Burnei's disease: teratological spondylolysis. ( 26664464 )
2015
34
Multiple-level lumbar spondylolysis and spondylolisthesis. ( 25525958 )
2015
35
Systematic review of observational studies reveals no association between low back pain and lumbar spondylolysis with or without isthmic spondylolisthesis. ( 25833204 )
2015
36
Spondylolysis and Beyond: Value of SPECT/CT in Evaluation of Low Back Pain in Children and Young Adults. ( 25969937 )
2015
37
Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene. ( 26077908 )
2015
38
Comparison of surgical treatment with direct repair versus conservative treatment in young patients with spondylolysis: a prospective, comparative, clinical trial. ( 25687414 )
2015
39
Lumbar spondylolysis and spondylolytic spondylolisthesis: who should be have surgery? An algorithmic approach. ( 25558333 )
2014
40
Spondylolysis and spondylolisthesis: What the primary care provider should know. ( 24170707 )
2014
41
L3-L5 Teratological Spondylolysis with Diastematomyelia and L4 Radicular Syndrome followed by Spondyloschisis without Myelomeningocele due to Somato-arcuate Shifting. ( 25264313 )
2014
42
Surgical management of multilevel lumbar spondylolysis: a case report and review of the literature. ( 24657151 )
2014
43
Management of spondylolysis and low-grade spondylolisthesis in fine athletes. A comprehensive review. ( 25394940 )
2014
44
The Use of Magnetic Resonance Imaging in the Evaluation of Spondylolysis. ( 24978120 )
2014
45
Direct Repair Surgery with Screw Fixation for Young Patients with Lumbar Spondylolysis: Patient-Reported Outcomes and Fusion Rate in a Prospective Interventional Study. ( 25398039 )
2014
46
Characteristics of Low Back Pain in Adolescent Patients with Early-stage Spondylolysis Evaluated by a Detailed Visual Analog Scale. ( 25341981 )
2014
47
Does the Prevalence of Spondylolysis and Spina Bifida Occulta Observed in Pediatric Patients Remain Stable in Adults? ( 25353203 )
2014
48
Clinical results and functional outcomes after direct intralaminar screw repair of spondylolysis. ( 24108299 )
2014
49
Bilateral C6 spondylolysis with spondylolisthesis in 3 adolescent siblings. ( 24531410 )
2014
50
Spondylolysis outcomes in adolescents after direct screw repair of the pars interarticularis. ( 24949906 )
2014

Variations for Spondylolysis

Expression for Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Pathways for Spondylolysis

Pathways related to Spondylolysis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.6 FTH1 PGRMC1 SLC7A11
2 11.3 BMP7 GDF5
3 11.18 BMP7 GDF5
4
Show member pathways
11.02 BMP7 GDF5
5 10.23 FTH1 SLC7A11

GO Terms for Spondylolysis

Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.4 BMP7 SLC26A2
2 positive regulation of neuron differentiation GO:0045666 9.37 BMP7 GDF5
3 cartilage development GO:0051216 9.32 BMP7 GDF5
4 SMAD protein signal transduction GO:0060395 9.26 BMP7 GDF5
5 embryonic limb morphogenesis GO:0030326 9.16 BMP7 GDF5
6 cell development GO:0048468 8.96 BMP7 GDF5
7 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 8.62 BMP7 GDF5

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP7 GDF5

Sources for Spondylolysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....