MCID: SPN020
MIFTS: 54

Spondylosis malady

Neuronal diseases category

Summaries for Spondylosis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Spondylosis is a term referring to degenerative osteoarthritis of the joints between the center of the... more...

MalaCards: Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to lung cancer and atherosclerosis. An important gene associated with Spondylosis is TSSK4 (testis-specific serine kinase 4), and among its related pathways are Vitamin D2 (ergocalciferol) metabolism and RXR and RAR heterodimerization with other nuclear receptor. The compounds doxercalciferol and (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 An bone structure disease that involves degeneration between vertebra located in vertebral column.

Aliases & Classifications for Spondylosis

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spondylosis 8 10 60
spondylogenic compression of thoracic spinal cord 8
spondylogenic compression of lumbar spinal cord 8
lumbosacral spondylosis without myelopathy 8
lumbar spondylosis with myelopathy 8
spondylosis with myelopathy 8
thoracic 8


External Ids:

Disease Ontology8 DOID:2247
ICD9CM27 721.9
MeSH34 D055009
ICD1025 M47, M47.9

Related Diseases for Spondylosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spondylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 710)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.7ENO2
2atherosclerosis30.5IL1B, WRN, HMGCR
3osteoarthritis30.4IL1B, VDR
4endometriosis30.4IL1B, HMGCR, ESR1
5radiculopathy30.4COL6A1
6spondylolisthesis30.3TSSK4
7hyperostosis30.3COL6A1
8spinal stenosis30.3TSSK4, COL6A1
9vascular disease30.3IL1B, ENO2, ESR1
10hypertension30.2PTH
11multiple sclerosis30.2VDR, HMGCR, IL1B
12meningitis30.2IL1B
13osteoporosis30.1VDR, HMGCR, PTH, ESR1, KL, WRN
14adenocarcinoma30.0NCOA1, ESR1, ENO2, HMGCR
15rheumatoid arthritis30.0IL1B, HMGCR
16osteomalacia30.0VDR, PTH, KL
17arthritis30.0HMGCR, VDR, IL1B
18peritonitis29.9IL1B
19astrocytoma29.9IL1B
20diabetes mellitus29.9VDR, IL1B, HMGCR, PTH
21arteriosclerosis29.8HMGCR
22hypercalcemia29.7PTH, VDR
23degenerative disc disease29.7IL1B
24adenoma29.7PTH, HMGCR, VDR, ENO2
25osteosarcoma29.7PTH, VDR, WRN, ESR1
26breast cancer29.7ESR1, CANT1, PTH, VDR, NCOA1, WRN
27stroke, ischemic29.5CANT1
28prostatitis29.5VDR
29pheochromocytoma29.5ENO2
30infertility29.5ESR1
31rickets29.5PTH, VDR
32rhabdomyosarcoma29.5ENO2, NCOA1
33uremia29.5VDR, PTH
34cervicitis11.2
35thoracic aortic aneurysm11.1
36aortic aneurysm11.1
37thoracic outlet syndrome11.0
38aortic disease10.7
39thoracic cancer10.7
40asphyxiating thoracic dystrophy10.7
41dissecting aortic aneurysm10.6
42ruptured thoracic aortic aneurysm10.6
43ruptured aortic aneurysm10.6
44esophagitis10.6
45spinal cord ischemia10.5
46pneumothorax10.5
47esophageal cancer10.4
48meningocele10.4
49familial thoracic aortic aneurysm and dissection10.4
50actinomycosis10.4

Graphical network of the top 20 diseases related to Spondylosis:



Diseases related to spondylosis

Clinical Features for Spondylosis

About this section

Drugs & Therapeutics for Spondylosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Spondylosis

Drug clinical trials:

Search ClinicalTrials for Spondylosis

Search NIH Clinical Center for Spondylosis

Search CenterWatch for Spondylosis

Genetic Tests for Spondylosis

About this section

Anatomical Context for Spondylosis

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Spondylosis:

32
Spinal cord, Bone, Cortex, Testes, Dorsal root ganglion

FMA organs/tissues related to Spondylosis:

14
Vertebral column

Animal Models for Spondylosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Spondylosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.0WRN, KL
2MP:00053908.1KL, WRN, NCOA1, VDR, IL1B, PTH
3MP:00053797.9BOLL, KL, WRN, NCOA1, VDR, PTH

Publications for Spondylosis

About this section
Sources:
50PubMed
See all sources

Articles related to Spondylosis:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Surgical Strategies in Interbody Titanium Cage Fixation for Cervical Spondylosis and Discogenic Disease. (23920293)
2013
2
The Compensatory Relationship of Upper and Subaxial Cervical Motion in the Presence of Cervical Spondylosis. (24077413)
2013
3
Effectiveness of acupuncture intervention for neck pain caused by cervical spondylosis: study protocol for a randomized controlled trial. (23800342)
2013
4
Syringomyelia associated with cervical spondylosis: A rare condition. (24303479)
2013
5
Anterior cervical discectomy and fusion versus anterior cervical corpectomy and fusion for multilevel cervical spondylosis: a systematic review. (21968573)
2012
6
Measures of spinal canal stenosis and relationship to spinal cord structure in patients with cervical spondylosis. (22033418)
2012
7
Outcomes of three anterior decompression and fusion techniques in the treatment of three-level cervical spondylosis. (21448583)
2011
8
Diffuse idiopathic skeletal hyperostosis (DISH) and spondylosis deformans in purebred dogs: a retrospective radiographic study. (21571557)
2011
9
Cervical spondylosis treated by acupuncture at Ligou (LR 5) combined with movement therapy. (20653167)
2010
10
Lumbar spondylosis: clinical presentation and treatment approaches. (19468872)
2009
11
Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts: the ROAD study. (18718988)
2009
12
The Plate cage Benezech implant as an alternative to autologous bone graft in the treatment of cervical spondylosis: clinical and functional outcome. (18661421)
2008
13
Treatment of cervical spondylosis by puncturing both the local and distal points--a report of 76 cases. (17393622)
2007
14
Neurological manifestations of cervical spondylosis: an overview of signs, symptoms, and pathophysiology. (17204875)
2007
15
Is there any relationship between proinflammatory mediator levels in disc material and myelopathy with cervical disc herniation and spondylosis? A non-randomized, prospective clinical study. (17476536)
2007
16
Severity and distribution of ventral thoracolumbar spondylosis and histological assessment of associated intervertebral disc degeneration in cull rams. (18059647)
2007
17
Use of resorbable implants for symptomatic cervical spondylosis: experience on 16 consecutive patients. (18176526)
2007
18
Minimally invasive surgery for the management of cervical spondylosis. (17204879)
2007
19
Cervical spondylosis: ventral or dorsal surgery. (17204873)
2007
20
The therapeutic effects of triple puncture and routine body needling for cervical spondylosis. (14719300)
2003
21
Unilateral drop finger due to cervical spondylosis at the C6/7 intervertebral level. (12898322)
2003
22
Amyotrophic lateral sclerosis: frequent complications by cervical spondylosis. (14648282)
2003
23
Preliminary experience with the DOC dynamic cervical implant for the treatment of multilevel cervical spondylosis. (12408387)
2002
24
Effects of cervical traction and exercise therapy in cervical spondylosis. (12825763)
2002
25
The role of cumulative physical work load in lumbar spine disease: risk factors for lumbar osteochondrosis and spondylosis associated with chronic complaints. (11600730)
2001
26
Proper management of the rotational vertebral artery occlusion secondary to spondylosis. (11714574)
2001
27
Surgery for degenerative lumbar spondylosis. (10796435)
2000
28
Surgical treatment of advanced lumbar spondylosis. (18034145)
2000
29
Dynamic changes of the spinal canal in patients with cervical spondylosis at flexion and extension using magnetic resonance imaging. (9704283)
1998
30
MRI of lumbar spondylosis: a comparison of sagittal T2 weighted and three sequence examinations. (9536901)
1997
31
Advanced cervical spondylosis with ossification into the posterior longitudinal ligament and resultant neurologic sequelae. (8976487)
1996
32
Motor recovery following spinal cord injury associated with cervical spondylosis: a collaborative study. (8961427)
1996
33
Spondylosis deformans in the boxer: estimates of heritability. (7603058)
1995
34
Spondylosis and lumbar instability: pathologic changes. (8076467)
1994
35
MRI of the cervical spine: rheumatoid arthritis compared with cervical spondylosis. (1884588)
1991
36
Neurosurgery for cervical spondylosis. (2673471)
1989
37
Anterior cervical vertebrectomy and interbody fusion for multi-level spondylosis and ossification of the posterior longitudinal ligament. (2501709)
1989
38
Treatment of cervical spondylosis. Electroacupuncture versus physiotherapy. (6346029)
1983
39
The results of anterior cervical fusion in cervical spondylosis. Review of 125 cases. (6880881)
1983
40
Somatosensory evoked potentials in diagnostics of cervical spondylosis and herniated disc. (6169504)
1981
41
Cervical myelopathy due to spondylosis. Case report. (624979)
1978
42
A rational approach to cervical disk lesions and spondylosis. (957939)
1976
43
Upper limb involvement in cervical spondylosis. (1141925)
1975
44
The importance of the sagittal diameters of the cervical spinal canal in relation to spondylosis and myelopathy. (4818851)
1974
45
Surgical treatment of cervical spondylosis. (4668426)
1972
46
Cervical spondylosis. (5095305)
1971
47
Cervical spondylosis. (5443538)
1970
48
Myelopathy in cervical spondylosis with vertebral subluxation and hyperlordosis. (5417937)
1970
49
Long-term results of surgical treatment of myelopathy due to cervical spondylosis. (5787848)
1969
50
Repetitive trauma in the genesis of cervical spondylosis. (5822318)
1969

Genetic Variations for Spondylosis

About this section

Expression for genes affiliated with Spondylosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spondylosis

Search GEO for disease gene expression data for Spondylosis.

Pathways for genes affiliated with Spondylosis

About this section
Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
See all sources

Pathways related to Spondylosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Vitamin D2 (ergocalciferol) metabolism
Hide members
9.9PTH, VDR
29.9VDR, NCOA1
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.6PTH, IL1B, VDR
49.6ESR1, VDR, KL
59.5NCOA1, VDR, ESR1

Compounds for genes affiliated with Spondylosis

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Spondylosis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1doxercalciferol4410.3VDR, PTH
2(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol1110.3NCOA1, VDR
31,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)1110.3NCOA1, VDR
4paricalcitol44 1111.2PTH, VDR
5[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.2NCOA1, ESR1
6bisphosphonates4910.2VDR, IL1B
7etidronic acid44 49 1112.1VDR, IL1B
87-dehydrocholesterol44 2411.0VDR, HMGCR
9alendronate44 49 1112.0VDR, PTH, ESR1
10creatinine4410.0PTH, HMGCR, VDR
11chenodeoxycholic acid44 28 11 2412.9HMGCR, VDR, NCOA1
12bicalutamide44 59 1111.9NCOA1, VDR, ESR1
13tamoxifen44 49 28 1112.9PTH, VDR, NCOA1
14raloxifene44 28 49 1112.8ESR1, VDR, NCOA1
15risedronate44 59 49 28 1113.8ESR1, IL1B
164-hydroxytamoxifen449.7ESR1, VDR, NCOA1
17calcitriol44 59 11 2412.6NCOA1, VDR, IL1B, PTH
18diethylstilbestrol44 28 1111.6NCOA1, ENO2, ESR1
19aspirin44 49 28 2412.6HMGCR, IL1B, VDR, CANT1
20mifepristone44 59 28 1112.6ESR1, IL1B, NCOA1
211,25 dihydroxy vitamin d3449.5ENO2, PTH, VDR, NCOA1
22prostaglandin449.5CANT1, IL1B, PTH, ENO2
23vitamin d449.5NCOA1, VDR, PTH, ESR1
24indomethacin44 59 28 1112.3CANT1, NCOA1, IL1B, ENO2
25genistein44 28 59 2 11 2414.3ESR1, IL1B, VDR, NCOA1, CANT1
26methotrexate44 49 1111.3IL1B, HMGCR, ENO2, ESR1
27troglitazone44 28 59 1112.2VDR, IL1B, HMGCR
28cycloheximide449.2VDR, IL1B, HMGCR, PTH, ESR1
29arginine449.2PTH, HMGCR, VDR, NCOA1, WRN, CANT1
30adenylate449.2CANT1, WRN, VDR, PTH, ENO2
31docetaxel44 49 59 1112.2VDR, ENO2, ESR1
32actinomycin d449.2ESR1, HMGCR, IL1B, VDR
33testosterone44 59 11 2411.9ESR1, ENO2, PTH, VDR, NCOA1
34vegf448.9ESR1, ENO2, PTH, HMGCR, IL1B, KL
35dexamethasone44 49 28 1111.9VDR, IL1B, HMGCR, PTH, ENO2

GO Terms for genes affiliated with Spondylosis

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mammary gland branching involved in pregnancyGO:0607459.7ESR1, VDR
2agingGO:0075689.4HMGCR, WRN, KL
3positive regulation of transcription from RNA polymerase II promoterGO:0459448.9VDR, IL1B, PTH, ESR1, NCOA1

Products for genes affiliated with Spondylosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spondylosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet