MCID: SPN020
MIFTS: 51

Spondylosis malady

Neuronal diseases, Bone diseases categories

Aliases & Classifications for Spondylosis

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Spondylosis, Aliases & Descriptions:

Name: Spondylosis 9 11 60
Lumbosacral Spondylosis Without Myelopathy 9 60
Lumbar Spondylosis with Myelopathy 9 60
Spondylosis with Myelopathy 9 60
 
Spondylogenic Compression of Thoracic Spinal Cord 9
Spondylogenic Compression of Lumbar Spinal Cord 9
Thoracic Spondylosis with Myelopathy 60
Thoracic 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Bone diseases


External Ids:

Disease Ontology9 DOID:2247
ICD9CM27 721.9
MeSH33 D055009
ICD1025 M47, M47.9

Summaries for Spondylosis

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Wikipedia:63 Spondylosis is a term referring to degenerative osteoarthritis of the joints between the center of the... more...

MalaCards based summary: Spondylosis, also known as lumbosacral spondylosis without myelopathy, is related to spondylolisthesis and spinal stenosis. An important gene associated with Spondylosis is TSSK4 (testis-specific serine kinase 4), and among its related pathways are Vitamin D synthesis and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds doxercalciferol and paricalcitol have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Disease Ontology:9 An bone structure disease that involves degeneration between vertebra located in vertebral column.

Related Diseases for Spondylosis

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Diseases related to Spondylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 830)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis31.2TSSK4
2spinal stenosis30.6COL6A1, TSSK4
3calcinosis30.4PTH, KL
4sarcoma30.4ENO2, WRN, VDR
5atherosclerosis30.4HMGCR, IL1B, WRN
6arteriosclerosis30.3HMGCR
7osteomalacia30.3KL, PTH, VDR
8endometriosis30.3IL1B, ESR1, HMGCR
9osteoporosis30.3ESR1, PTH, VDR
10parathyroid adenoma30.1VDR, PTH
11renal osteodystrophy29.9PTH, VDR
12hypercalcemia29.9PTH, VDR
13rickets29.8VDR, PTH
14arthritis29.8VDR, IL1B, HMGCR
15uremia29.7PTH, VDR
16vascular disease29.7ESR1, ENO2, IL1B
17hyperparathyroidism29.7PTH, KL, VDR
18kidney disease29.6VDR, KL, IL1B
19adenoma29.5PTH, VDR, HMGCR, ENO2
20arthropathy29.5HMGCR, IL1B
21cervicitis11.2
22aneurysm11.1
23aortic aneurysm11.1
24thoracic aortic aneurysm11.1
25thoracic outlet syndrome11.1
26aortic disease10.8
27asphyxiating thoracic dystrophy10.7
28neurogenic thoracic outlet syndrome10.7
29esophagitis10.6
30thoracic cancer10.6
31pneumothorax10.5
32familial thoracic aortic aneurysm and dissection10.5
33lung cancer10.5
34hypervitaminosis d10.5KL
35meningocele10.5
36spontaneous pneumothorax10.5
37esophageal cancer10.5
38actinomycosis10.4
39mediastinitis10.4
40venous thoracic outlet syndrome10.4
41marfan syndrome10.4
42aortitis10.4
43arterial thoracic outlet syndrome10.4
44osteoarthritis10.4
45syringomyelia10.4
46aortic atherosclerosis10.4
47hemangioma10.4
48ischemic heart disease10.4
49radiculopathy10.4
50hyperostosis10.4

Graphical network of the top 20 diseases related to Spondylosis:



Diseases related to spondylosis

Symptoms for Spondylosis

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Drugs & Therapeutics for Spondylosis

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Drug clinical trials:

Search ClinicalTrials for Spondylosis

Search NIH Clinical Center for Spondylosis

Genetic Tests for Spondylosis

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Anatomical Context for Spondylosis

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MalaCards organs/tissues related to Spondylosis:

31
Spinal cord, Bone, Cortex, Testes, Dorsal root ganglion

FMA organs/tissues related to Spondylosis:

14
Vertebral column

Animal Models for Spondylosis or affiliated genes

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MGI Mouse Phenotypes related to Spondylosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8KL, ESR1, WRN, PTH, VDR
2MP:00053798.5VDR, PTH, WRN, ESR1, KL
3MP:00053908.3VDR, PTH, WRN, ESR1, IL1B, KL
4MP:00053858.2VDR, PTH, WRN, ESR1, IL1B, KL
5MP:00053848.1ENO2, KL, COL6A1, ESR1, WRN, VDR
6MP:00053877.9VDR, PTH, WRN, ESR1, IL1B, KL
7MP:00107687.0VDR, PTH, WRN, ESR1, IL1B, KL

Publications for Spondylosis

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Articles related to Spondylosis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Persistent Outpatient Hypertension is Independently Associated with Spinal Cord Dysfunction and Imaging Characteristics of Spinal Cord Damage among Patients with Cervical Spondylosis. (25819526)
2015
2
The concomitance of cervical spondylosis and adult thoracolumbar spinal deformity. (24715867)
2014
3
Pregabalin and Radicular Pain Study (PARPS) for Cervical Spondylosis in a Multiracial Asian Population. (24400034)
2014
4
Syringomyelia secondary to cervical spondylosis: Case report and review of literature. (25540552)
2014
5
Clinical efficacy of Eranda Muladi Yapana Basti in the management of Kati Graha (Lumbar spondylosis). (24049403)
2013
6
Is there a difference in range of motion, neck pain, and outcomes in patients with ossification of posterior longitudinal ligament versus those with cervical spondylosis, treated with plated laminoplasty? (23815254)
2013
7
Long-term outcome of the Cloward procedure for single-level cervical degenerative spondylosis. Clinical and radiological assessment after a 22-year mean follow-up. (24114077)
2013
8
The optimized acupuncture treatment for neck pain caused by cervical spondylosis: a study protocol of a multicentre randomized controlled trial. (22776567)
2012
9
Differences between soft-disc herniation and spondylosis in cervical arthroplasty: CT-documented heterotopic ossification with minimum 2 years of follow-up. (22136390)
2012
10
Cervical spondylosis treated by acupuncture at Ligou (LR 5) combined with movement therapy. (20653167)
2010
11
A concomitant posterior approach improves fusion rates but not overall reoperation rates in multilevel cervical fusion for spondylosis. (19412017)
2009
12
Treatment of cervical spondylosis by puncturing both the local and distal points--a report of 76 cases. (17393622)
2007
13
Surgery for degenerative lumbar spondylosis: updated Cochrane Review. (16227895)
2005
14
Clinicoradiological review: dural arteriovenous fistula and cervical spondylosis mimicking multiple sclerosis. (15918949)
2005
15
Diaphragmatic paralysis caused by cervical spondylosis. Case report. (15945437)
2005
16
Syringomyelia caused by cervical spondylosis. (14963752)
2004
17
Dysphagia induced by a cervical osteophyte: a case report of cervical spondylosis. (15043799)
2004
18
Clinical and radiological correlates of severity and surgery-related outcome in cervical spondylosis. (11302619)
2001
19
Cervical spondylosis: contrast-enhanced magnetization transfer prepulsed 3D turbo field echo MR imaging. (10739561)
2000
20
Surgery for degenerative lumbar spondylosis. (10796435)
2000
21
A new surgical technique: open-window corpectomy in the treatment of ossification of the posterior longitudinal ligament and advanced cervical spondylosis: technical note. (10598719)
1999
22
Quantitative analysis of cerebrospinal fluid flow in patients with cervical spondylosis using cine phase-contrast magnetic resonance imaging. (10201303)
1999
23
Surgical outcome in patients with coexisting multiple sclerosis and spondylosis. (10442447)
1999
24
Ossification of the yellow ligament and spondylosis and/or ossification of the posterior longitudinal ligament of the thoracic and lumbar spine. (10382780)
1999
25
The efficacy and safety of eperisone in patients with cervical spondylosis: results of a randomized, double-blind, placebo-controlled trial. (10389124)
1999
26
Dynamic changes of the spinal canal in patients with cervical spondylosis at flexion and extension using magnetic resonance imaging. (9704283)
1998
27
Cervical spondylosis in paraplegic patients and analysis of the wheelchair driving action: a preliminary communication. (9392049)
1997
28
The comparison of a rapid screening MR protocol with a conventional MR protocol for lumbar spondylosis. (8610572)
1996
29
The role of distraction in improving the space available for the cord in cervical spondylosis. (7701388)
1995
30
Anatomical treatment of cervical spondylosis. (7842609)
1994
31
Pre- and postoperative motor conduction times, measured using magnetic stimulation, in patients with cervical spondylosis. (2397044)
1990
32
F-response frequency in motor neuron disease and cervical spondylosis. (3585384)
1987
33
Observation of 30 cases of cervical spondylosis treated by electro-acupuncture. (3497311)
1987
34
Radiculopathy in spondylosis/spondylolisthesis. The laminar/ligamentum flavum process. (2980607)
1986
35
"Open door" operation to raise the vertebral arch in myelopathy due to cervical spondylosis. (6735722)
1984
36
Surgery for myelopathy in cervical spondylosis: safety measures and preoperative factors related to outcome. (7394659)
1980
37
Retrospective study of cervical spondylosis treated by anterior interbody fusion (in 505 patients performed by the Cloward technique). (687852)
1978
38
Pathology and pathogenesis of lumbar spondylosis and stenosis. (741238)
1978
39
Spondylosis in the whale--an anatomicoradiological study of an osteophyte. (607394)
1977
40
A rational approach to cervical disk lesions and spondylosis. (957939)
1976
41
Treatment of cervical spondylosis. (1000216)
1976
42
Cervical spondylosis: most common cause of position and vibratory sense loss. (939424)
1976
43
Letter: Pathogenesis of myelopathy in cervical spondylosis. (48816)
1975
44
Cervical spondylosis. (1132207)
1975
45
Cervical spondylosis and pseudomyotonia. (4421040)
1974
46
Surgical treatment of cervical spondylosis. (4668426)
1972
47
A set of new instruments for lumbar spondylosis. (5073270)
1972
48
The posterior operation in treatment of cervical spondylosis with myelopathy: a long-term follow-up study. (5096553)
1971
49
Athetoid movements in cervical spondylosis. (5427424)
1970
50
The patient with cervical spondylosis. (5207601)
1969

Variations for Spondylosis

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Expression for genes affiliated with Spondylosis

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Search GEO for disease gene expression data for Spondylosis.

Pathways for genes affiliated with Spondylosis

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Pathways related to Spondylosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8VDR, PTH
29.8PTH, VDR
3
Show member pathways
Nuclear Receptors36
9.5ESR1, VDR
49.3IL1B, PTH, VDR
59.2KL, ESR1, VDR

Compounds for genes affiliated with Spondylosis

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Compounds related to Spondylosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1doxercalciferol4310.2VDR, PTH
2paricalcitol43 1211.2PTH, VDR
37-dehydrocholesterol43 2411.1HMGCR, VDR
4deoxypyridinoline4310.1PTH, VDR
5lactone4310.1VDR, HMGCR
6thiazide4310.1HMGCR, VDR
7etidronic acid43 49 1212.0IL1B, VDR
8bisphosphonates4910.0VDR, IL1B
925-hydroxyvitamin d4310.0PTH, VDR
10clodronate43 49 1212.0VDR, IL1B
11phosphorus4310.0PTH, VDR
12naringenin43 1210.9ESR1, HMGCR
13xbai439.9VDR, ESR1
14risedronate43 49 28 59 1213.9IL1B, ESR1
15eb 108943 5910.9ESR1, VDR
16bicalutamide43 59 1211.8ESR1, VDR
17thyroxine43 2410.8HMGCR, PTH, VDR
18chenodeoxycholic acid43 28 24 1212.8VDR, HMGCR
19leflunomide43 49 1211.8ESR1, IL1B
20il 10439.8VDR, IL1B
21flutamide43 59 1211.7ESR1, ENO2
22alendronate43 49 1211.7ESR1, PTH, VDR
231,25 dihydroxy vitamin d3439.7ENO2, PTH, VDR
24calcitriol43 59 24 1212.7VDR, PTH, IL1B
25troglitazone43 28 59 1212.7HMGCR, IL1B, VDR
26ibmx43 59 2811.6PTH, IL1B, ENO2
27diethylstilbestrol43 28 1211.6ENO2, ESR1
28prostaglandin439.6ENO2, IL1B, PTH
29aspirin43 49 28 2412.6HMGCR, IL1B, VDR
30ribonucleic acid439.5PTH, IL1B, ENO2
31tamoxifen43 49 28 1212.5ESR1, PTH, VDR
32vitamin d439.5VDR, PTH, ESR1
33mg 13243 5910.5IL1B, ESR1, VDR
34raloxifene43 49 28 1212.4ESR1, VDR
35docetaxel43 49 59 1212.4ENO2, ESR1, VDR
36magnesium43 24 1211.4PTH, WRN, TSSK4, ENO2
37arginine439.4HMGCR, WRN, PTH, VDR
38adenylate439.3VDR, PTH, WRN, ENO2
39creatinine439.3VDR, PTH, HMGCR, ENO2
40thymidine43 2410.2VDR, PTH, IL1B, ENO2
41forskolin43 49 1211.2ENO2, IL1B, PTH
42actinomycin d439.2VDR, ESR1, IL1B, HMGCR
43testosterone43 59 24 1212.1ENO2, ESR1, PTH, VDR
44methotrexate49 43 1211.0ENO2, HMGCR, IL1B, ESR1
45cycloheximide438.9VDR, PTH, ESR1, IL1B, HMGCR
46dexamethasone43 49 28 1211.9VDR, PTH, IL1B, HMGCR, ENO2
47estrogen438.8ENO2, ESR1, PTH, VDR
48cysteine438.7VDR, WRN, COL6A1, HMGCR
49retinoic acid43 249.6VDR, ESR1, IL1B, ENO2
50vegf438.5ENO2, PTH, ESR1, IL1B, KL, HMGCR

GO Terms for genes affiliated with Spondylosis

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Cellular components related to Spondylosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.9ENO2, KL, IL1B, PTH
2extracellular regionGO:00055768.2KL, COL6A1, IL1B, PTH, C12orf39

Biological processes related to Spondylosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of bone mineralizationGO:00305019.8PTH, KL
2mammary gland branching involved in pregnancyGO:00607459.7ESR1, VDR
3negative regulation of MAP kinase activityGO:00434079.6HMGCR, IL1B
4agingGO:00075689.5HMGCR, KL, WRN
5positive regulation of nitric oxide biosynthetic processGO:00454299.5IL1B, ESR1
6positive regulation of transcription from RNA polymerase II promoterGO:00459448.5IL1B, ESR1, PTH, VDR

Molecular functions related to Spondylosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:00037079.5ESR1, VDR
2magnesium ion bindingGO:00002879.0ENO2, TSSK4, WRN

Products for genes affiliated with Spondylosis

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Sources for Spondylosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet