Spondylosis malady

Wikipedia: Spondylosis is a term referring to degenerative osteoarthritis of the joints between the centre of the...⁴⁴ more...

MalaCards: Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to aortic aneurysm and spinal stenosis. An important gene associated with Spondylosis is IFIT1 (interferon-induced protein with tetratricopeptide repeats 1), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Endocrine and other factor-regulated calcium reabsorption. The compounds 4-hydroxytamoxifen and doxercalciferol have been mentioned in the context of this disorder. Affiliated tissues include vertebral column and spinal cord, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology: An bone structure disease that involves degeneration between vertebra located in vertebral column.⁶

Aliases & Descriptions:

spondylosis 6 8 43 spondylogenic compression of thoracic spinal cord 6 spondylogenic compression of lumbar spinal cord 6 lumbar spondylosis with myelopathy (disorder) 6 lumbosacral spondylosis without myelopathy 6 spondylosis with myelopathy (disorder) 6

lumbar spondylosis with myelopathy 6 spondylosis with myelopathy 6 lumbosacral spondylosis 43 lumbar spondylosis 43 thoracic 6

Diseases related to spondylosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 204)

id	Related Disease	Score	Top Affiliating Genes
1	aortic aneurysm	31.9	ESR1, ENO2, IL1B, HMGCR
2	spinal stenosis	26.3	COL6A1, IFIT1, VDR
3	mediastinitis	25.8	PTH, ESR1, ENO2
4	scoliosis	25.4	CANT1, ESR1, VDR
5	periodic fever	25.2	HMGCR, IL1B
6	osteoarthritis	24.8	ENO2, IL1B, VDR, KL, ESR1, HMGCR
7	hypercholesterolemia	24.6	ESR1, IL1B, CANT1, HMGCR
8	breast cancer	24.4	ESR1, WRN, IL1B, VDR
9	osteoporosis	24.3	KL, VDR, IL1B, ESR1, HMGCR, PTH
10	thrombosis	24.1	HMGCR, CANT1, IL1B, ESR1
11	hypertension	24.0	PTH, HMGCR, ESR1, IL1B, KL, WRN
12	pneumonia	23.8	KL, HTRA1, PTH, HMGCR, IL1B, ENO2
13	squamous cell carcinoma	23.5	HMGCR, ESR1, VDR, NCOA1, WRN, ENO2
14	carcinoma	23.5	ESR1, NCOA1, CANT1, HTRA1, ENO2, IL1B
15	endometriosis	23.5	VDR, IL1B, ESR1, HMGCR, NCOA1
16	atherosclerosis	23.1	WRN, KL, PTH, HMGCR, VDR, CANT1
17	cerebritis	23.1	CANT1, IL1B, ENO2, HTRA1, ESR1, HMGCR
18	sarcoma	22.8	IL1B, WRN, ESR1, ENO2, NCOA1, VDR
19	diabetes mellitus	22.6	ESR1, ENO2, IL1B, VDR, PTH, WRN
20	osteosarcoma	22.2	ESR1, WRN, NCOA1, VDR, IL1B, ENO2
21	cholesterol	22.0	IL1B, VDR, NCOA1, KL, ENO2, CANT1
22	pancreatitis	21.9	KL, WRN, PTH, VDR, IL1B, ENO2
23	hyperostosis	13.1	KL, PTH, COL6A1
24	vitamin d-dependent rickets type ii	13.0	PTH, VDR
25	female breast carcinoma	12.9	ENO2, ESR1
26	developmental dysplasia of hip	12.8	ESR1, VDR
27	hypervitaminosis d	12.8	VDR, KL, PTH
28	familial hypophosphatemia	12.8	KL, PTH, VDR
29	hyperphosphatemia	12.7	KL, VDR, PTH
30	hypophosphatemia	12.7	KL, VDR, PTH
31	leydig cell tumor	12.7	ENO2, ESR1, PTH
32	spondylolisthesis	12.7	ESR1, NCOA1
33	osteopenia/osteoporosis	12.7	VDR, ESR1
34	osteomalacia	12.7	KL, VDR, PTH
35	primary hyperparathyroidism	12.7	PTH, VDR, KL
36	vulvar vestibulitis syndrome	12.6	ESR1, IL1B
37	neuroendocrine carcinoma	12.6	KL, ESR1, ENO2
38	periostitis	12.5	IL1B, KL, PTH
39	osteoporosis, postmenopausal	12.5	VDR, PTH, ESR1
40	campylobacteriosis	12.4	IL1B, VDR
41	was-related disorders	12.4	WRN, VDR, COL6A1, KL
42	osteonecrosis	12.2	PTH, ESR1, VDR, KL
43	tourette syndrome	12.2	IL1B, ENO2, HMGCR
44	nephrolithiasis	12.2	VDR, PTH, IL1B
45	giant cell tumor	12.1	IL1B, PTH, ESR1
46	chronic kidney failure	12.0	HMGCR, VDR
47	urolithiasis	12.0	IL1B, ESR1, VDR
48	familial hypercholesterolemia	12.0	HMGCR, IL1B, ESR1
49	rhabdomyosarcoma	12.0	ENO2, ESR1, NCOA1, PTH
50	hypercalciuria	11.9	VDR, KL, PTH, IL1B

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spondylosis:

²²

FMA organs/tissues related to spondylosis:

¹¹

MGI Mouse Phenotypes related to spondylosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	8.3	NCOA1, VDR, ESR1, PTH, WRN
2	limbs/digits/tail phenotype	MP:0005371	8.2	WRN, PTH, ESR1, VDR, KL
3	endocrine/exocrine gland phenotype	MP:0005379	7.7	WRN, PTH, ESR1, BOLL, VDR, NCOA1
4	cardiovascular system phenotype	MP:0005385	7.3	KL, VDR, IL1B, HTRA1, ESR1, PTH

Articles related to spondylosis:

id	Title	Authors	Year	Affiliating Genes
1	Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in post-menopausal women. (16362385)	Koshizuka Y.... Kawaguchi H.	2006	VDR, ESR1, IL1B
2	Hypothalamic digoxin and hemispheric chemical dominance--relation to the pathogenesis of senile osteoporosis, degenerative osteoarthritis, and spondylosis. (12803138)	Kurup R.K.... Kurup P.A.	2003	HMGCR
3	Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. (12110410)	Ogata N.... Kawaguchi H.	2002	KL
4	A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women. (11498731)	Ogata N.... Kawaguchi H.	2001	WRN
5	Neuron-specific enolase (NSE) and S-100b protein in cerebrospinal fluid of patients with cervical spondylosis--the relations with MRI findings and the changes of NSE and S-100b protein levels through Glisson's traction (1301336)	Yasuda T.... Kato K.	1992	ENO2

Genes related to spondylosis according to GeneCards:

(show all 15)

id	Symbol	Description	Score	GeneCards Section Context
1	IFIT1	interferon-induced protein with tetratricopeptide repeats 1	11.0
2	BOLL	bol, boule-like (Drosophila)	11.0
3	PTH	parathyroid hormone	11.0	Publications
4	KL	klotho	11.0	Publications
5	ANXA13	annexin A13	11.0	Disorders
6	HTRA1	HtrA serine peptidase 1	11.0
7	COL6A1	collagen, type VI, alpha 1	11.0
8	WRN	Werner syndrome, RecQ helicase-like	11.0	Publications
9	CANT1	calcium activated nucleotidase 1	11.0
10	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
11	NCOA1	nuclear receptor coactivator 1	11.0
12	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
13	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
14	IL1B	interleukin 1, beta	11.0	Publications
15	ESR1	estrogen receptor 1	11.0	Publications

Pathways related to spondylosis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.8	VDR, IL1B, PTH
2	Endocrine and other factor-regulated calcium reabsorption20	8.8	KL, VDR, ESR1
3	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.7	VDR, IL1B, PTH

Compounds related to spondylosis according to GeneDecks:

(show all 32)

id	Compound	Score	Top Affiliating Genes
1	4-hydroxytamoxifen32	10.3	NCOA1
2	doxercalciferol32 42	11.0	PTH, VDR
3	[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE9 9	10.9	ESR1, NCOA1
4	paricalcitol32 9 9	11.9	PTH, VDR
5	(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol9 9	10.8	NCOA1, VDR
6	1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)9 9	10.8	NCOA1, VDR
7	alendronate32 9 9	11.5	VDR, ESR1, PTH
8	7-dehydrocholesterol32 18	10.4	HMGCR, VDR
9	diethylstilbestrol32 9 9	11.4	ESR1, ENO2, NCOA1
10	bicalutamide32 42 9 9	12.3	ESR1, VDR, NCOA1
11	chenodeoxycholic acid32 9 18 9	12.2	NCOA1, VDR, HMGCR
12	raloxifene32 9 9	11.2	NCOA1, VDR, ESR1
13	1,25 dihydroxy vitamin d332	9.1	NCOA1, VDR, ENO2, PTH
14	docetaxel32 34 9 9	12.1	VDR, ENO2, ESR1
15	prostaglandin32	9.0	IL1B, ENO2, CANT1, PTH
16	tamoxifen32 34 9 9	11.8	PTH, ESR1, VDR, NCOA1
17	vitamin d32	8.8	NCOA1, VDR, ESR1, PTH
18	adenylate32	8.8	VDR, ENO2, CANT1, PTH, WRN
19	mifepristone32 42 9 9	11.7	NCOA1, IL1B, ESR1
20	ibmx32	8.7	PTH, ENO2, IL1B
21	indomethacin32 9 9	10.7	NCOA1, IL1B, ENO2, CANT1
22	calcitriol32 42 9 18 9	12.7	PTH, IL1B, VDR, NCOA1
23	creatinine32	8.6	PTH, HMGCR, CANT1, ENO2, VDR
24	methotrexate32 34 42 9 9	12.5	HMGCR, ESR1, ENO2, IL1B
25	troglitazone32 42 9 9	11.5	VDR, IL1B, HMGCR
26	testosterone32 9 18 9	11.4	PTH, ESR1, ENO2, VDR, NCOA1
27	arginine32	8.3	WRN, PTH, HMGCR, CANT1, VDR, NCOA1
28	genistein32 9 18 9	11.0	ESR1, CANT1, IL1B, VDR, NCOA1
29	vegf32	8.0	PTH, HMGCR, ESR1, ENO2, IL1B, KL
30	cycloheximide32	8.0	PTH, HMGCR, ESR1, IL1B, VDR
31	actinomycin d32	7.9	VDR, IL1B, ESR1, HMGCR
32	dexamethasone32 42 34 9 9	11.8	PTH, HMGCR, ENO2, IL1B, VDR

Biological processes related to spondylosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	NCOA1, VDR, IL1B, ESR1, PTH
2	aging	GO:007568	7.6	WRN, HMGCR, IL1B, VDR, KL
3	response to estradiol stimulus	GO:032355	7.5	NCOA1, VDR, IL1B, ENO2, ESR1

Molecular functions related to spondylosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	vitamin D binding	GO:005499	9.6	KL, VDR