MCID: SPN020
MIFTS: 54

Spondylosis malady

Neuronal diseases category

Summaries for Spondylosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Spondylosis is a term referring to degenerative osteoarthritis of the joints between the center of the... more...

MalaCards: Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to lung cancer and atherosclerosis. An important gene associated with Spondylosis is TSSK4 (testis-specific serine kinase 4), and among its related pathways are Vitamin D2 (ergocalciferol) metabolism and RXR and RAR heterodimerization with other nuclear receptor. The compounds doxercalciferol and (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 An bone structure disease that involves degeneration between vertebra located in vertebral column.

Aliases & Classifications for Spondylosis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spondylosis 8 10 60
spondylogenic compression of thoracic spinal cord 8
spondylogenic compression of lumbar spinal cord 8
lumbosacral spondylosis without myelopathy 8
lumbar spondylosis with myelopathy 8
spondylosis with myelopathy 8
thoracic 8


External Ids:

Disease Ontology8 DOID:2247
ICD9CM27 721.9
MeSH34 D055009
ICD1025 M47, M47.9

Related Diseases for Spondylosis

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17GeneCards, 18GeneDecks
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Diseases related to Spondylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 710)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.7ENO2
2atherosclerosis30.5IL1B, WRN, HMGCR
3osteoarthritis30.4IL1B, VDR
4endometriosis30.4IL1B, HMGCR, ESR1
5radiculopathy30.4COL6A1
6spondylolisthesis30.3TSSK4
7hyperostosis30.3COL6A1
8spinal stenosis30.3TSSK4, COL6A1
9vascular disease30.3IL1B, ENO2, ESR1
10hypertension30.2PTH
11multiple sclerosis30.2VDR, HMGCR, IL1B
12meningitis30.2IL1B
13osteoporosis30.1VDR, HMGCR, PTH, ESR1, KL, WRN
14adenocarcinoma30.0NCOA1, ESR1, ENO2, HMGCR
15rheumatoid arthritis30.0IL1B, HMGCR
16osteomalacia30.0VDR, PTH, KL
17arthritis30.0HMGCR, VDR, IL1B
18peritonitis29.9IL1B
19astrocytoma29.9IL1B
20diabetes mellitus29.9VDR, IL1B, HMGCR, PTH
21arteriosclerosis29.8HMGCR
22hypercalcemia29.7PTH, VDR
23degenerative disc disease29.7IL1B
24adenoma29.7PTH, HMGCR, VDR, ENO2
25osteosarcoma29.7PTH, VDR, WRN, ESR1
26breast cancer29.7ESR1, CANT1, PTH, VDR, NCOA1, WRN
27stroke, ischemic29.5CANT1
28prostatitis29.5VDR
29pheochromocytoma29.5ENO2
30infertility29.5ESR1
31rickets29.5PTH, VDR
32rhabdomyosarcoma29.5ENO2, NCOA1
33uremia29.5VDR, PTH
34cervicitis11.2
35thoracic aortic aneurysm11.1
36aortic aneurysm11.1
37thoracic outlet syndrome11.0
38aortic disease10.7
39thoracic cancer10.7
40asphyxiating thoracic dystrophy10.7
41dissecting aortic aneurysm10.6
42ruptured thoracic aortic aneurysm10.6
43ruptured aortic aneurysm10.6
44esophagitis10.6
45spinal cord ischemia10.5
46pneumothorax10.5
47esophageal cancer10.4
48meningocele10.4
49familial thoracic aortic aneurysm and dissection10.4
50actinomycosis10.4

Graphical network of the top 20 diseases related to Spondylosis:



Diseases related to spondylosis

Clinical Features for Spondylosis

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Drugs & Therapeutics for Spondylosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Spondylosis

Drug clinical trials:

Search ClinicalTrials for Spondylosis

Search NIH Clinical Center for Spondylosis

Search CenterWatch for Spondylosis

Genetic Tests for Spondylosis

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Anatomical Context for Spondylosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Spondylosis:

32
Spinal cord, Bone, Cortex, Testes, Dorsal root ganglion

FMA organs/tissues related to Spondylosis:

14
Vertebral column

Animal Models for Spondylosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spondylosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.0WRN, KL
2MP:00053908.1ESR1, KL, WRN, NCOA1, VDR, IL1B
3MP:00053797.9ESR1, KL, WRN, NCOA1, VDR, PTH

Publications for Spondylosis

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50PubMed
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Articles related to Spondylosis:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Clinical efficacy of Eranda Muladi Yapana Basti in the management of Kati Graha (Lumbar spondylosis). (24049403)
2013
2
Early Morbidity of Multilevel Anterior Cervical Discectomy and Fusion with Plating for Spondylosis: Does the Number of Levels Influence Early Complications? A Single Surgeon's Experience in 519 Consecutive Patients. (24436695)
2013
3
Prevalence, incidence and progression of lumbar spondylosis by gender and age strata. (24252032)
2013
4
Dual-energy subtraction radiography improves laryngeal delineation in patients with moderate to severe cervical spondylosis. (23744489)
2013
5
Teaching neuroimages: "pancake-like" gadolinium enhancement suggests compressive myelopathy due to spondylosis. (23690303)
2013
6
Anterior cervical interbody fusion using polyetheretherketone cage filled with autologous and synthetic bone graft substrates for cervical spondylosis: comparative analysis between PolyBoneAr and iliac bone. (23438658)
2013
7
Psychological attachment in patients with spondylosis of cervical and lumbar spine. (22826087)
2013
8
Spondylosis deformans and diffuse idiopathic skeletal hyperostosis (dish) resulting in adjacent segment disease. (22734148)
2012
9
Vertigo is associated with advanced degenerative changes in patients with cervical spondylosis. (21597927)
2011
10
Anterior cervical discectomy and fusion to treat cervical spondylosis with sympathetic symptoms. (20625322)
2011
11
A concomitant posterior approach improves fusion rates but not overall reoperation rates in multilevel cervical fusion for spondylosis. (19412017)
2009
12
Clinical research on treatment of vertebroarterial type of cervical spondylosis with 5-step manipulation and traction. (20112485)
2009
13
Degenerative cervical spondylosis: clinical syndromes, pathogenesis, and management. (18399602)
2008
14
Surgical treatment of cervical spondylosis in the elderly: surgical outcomes, risk factors, and complications. (18812678)
2008
15
Episodic vertigo resulting from vascular risk factors, cervical spondylosis and head rotation: Two case reports. (19300597)
2007
16
Surgical outcome of posterior decompression for cervical spondylosis with unilateral upper extremity amyotrophy. (16985439)
2006
17
A case of syringomyelia associated with cervical spondylosis. (16980666)
2006
18
Transcranial magnetic stimulation screening for cord compression in cervical spondylosis. (16478626)
2006
19
Diaphragmatic paralysis caused by cervical spondylosis. Case report. (15945437)
2005
20
A traumatic central cord syndrome occurring after adequate decompression for cervical spondylosis: biomechanics of injury: case report. (16227878)
2005
21
Acute arm paresis with cervical spondylosis: three case reports. (15734505)
2005
22
Pectoralis major motor evoked potentials in cervical spondylosis. (15939436)
2005
23
Radicular myoclonus induced by repetitive neck movements in a patient with cervical spondylosis. (15596784)
2004
24
Cervical vertigo and cervical spondylosis--a need for adequate evaluation. (14737984)
2003
25
Spinal cord edema: unusual magnetic resonance imaging findings in cervical spondylosis. (12859052)
2003
26
What is your diagnosis? Emphysematous cystitis, pneumaturia and lumbar spondylosis. (11280398)
2001
27
Surgical outcome in patients with coexisting multiple sclerosis and spondylosis. (10442447)
1999
28
Management of multilevel cervical spondylosis with myelopathy. (9952115)
1999
29
Anatomic considerations for uncovertebral involvement in cervical spondylosis. (9005914)
1997
30
The biological factors in the etiopathogenesis and management of cervical spondylosis. (8045623)
1994
31
Neuron-specific enolase and S-100 protein levels in cerebrospinal fluid of patients with cervical spondylosis and ossification of posterior longitudinal ligaments]. (2126231)
1990
32
Extradural brucellosis granuloma with 'subtle' spondylosis: a rare cause of spinal cord compression. (2261109)
1990
33
Electrophysiological studies in cervical spondylosis. (2562447)
1989
34
Osteoarthritis X: Cervical spondylosis. (3849655)
1985
35
Surgical treatment of sympathetic cervical spondylosis. (6785028)
1981
36
Anterior fusion for cervical spondylosis. (81289)
1978
37
Spondylosis in the whale--an anatomicoradiological study of an osteophyte. (607394)
1977
38
Increased frequency of HLA B8 in hyperostotic spondylosis. (266608)
1977
39
Headache, cervical spondylosis, and anterior cervical fusion. (882900)
1977
40
Treatment of cervical spondylosis. (1000216)
1976
41
Cervical spondylosis. (1003156)
1976
42
Effects of certain degenerative diseases of the spine, especially spondylosis and disk protrusion, on the neural contents, particularly in the lumbar region. Historical account. (1092927)
1975
43
Letter: Myelopathy in cervical spondylosis. (4140368)
1974
44
Studies on pathogenesis of cervical spondylotic myelopathy: sagittal diameter of the spinal canal and cerebrospinal fluid characteristics in cervical spondylosis. (4134818)
1974
45
Significance of the small lumbar spinal canal: cauda equina compression syndromes due to spondylosis. 4. Acute compression artifically-induced during operation. (5351761)
1969
46
The importance of removing osteophytes as part of the surgical treatment of myeloradiculopathy in cervical spondylosis. (5780893)
1969
47
Cervical spondylosis: the neurological mimic. (5254345)
1969
48
Cervical spondylosis in the cat. (5689176)
1968
49
The role of cervical spondylosis in the aetiology of cerebral embolism. (6074705)
1967
50
Cervical spondylosis in patients with athetosis. (13861319)
1962

Genetic Variations for Spondylosis

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Expression for genes affiliated with Spondylosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylosis

Search GEO for disease gene expression data for Spondylosis.

Pathways for genes affiliated with Spondylosis

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Spondylosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Vitamin D2 (ergocalciferol) metabolism
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9.9PTH, VDR
29.9VDR, NCOA1
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.6PTH, IL1B, VDR
49.6KL, VDR, ESR1
59.5VDR, ESR1, NCOA1

Compounds for genes affiliated with Spondylosis

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Spondylosis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1doxercalciferol4410.3VDR, PTH
2(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol1110.3NCOA1, VDR
31,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)1110.3NCOA1, VDR
4paricalcitol44 1111.2PTH, VDR
5[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.2NCOA1, ESR1
6bisphosphonates4910.2VDR, IL1B
7etidronic acid44 49 1112.1VDR, IL1B
87-dehydrocholesterol44 2411.0VDR, HMGCR
9alendronate44 49 1112.0VDR, PTH, ESR1
10creatinine4410.0PTH, HMGCR, VDR
11chenodeoxycholic acid44 28 11 2412.9HMGCR, VDR, NCOA1
12bicalutamide44 59 1111.9NCOA1, VDR, ESR1
13tamoxifen44 49 28 1112.9PTH, VDR, NCOA1
14raloxifene44 28 49 1112.8ESR1, VDR, NCOA1
15risedronate44 59 49 28 1113.8ESR1, IL1B
164-hydroxytamoxifen449.7ESR1, VDR, NCOA1
17calcitriol44 59 11 2412.6NCOA1, VDR, IL1B, PTH
18diethylstilbestrol44 28 1111.6NCOA1, ENO2, ESR1
19aspirin44 49 28 2412.6HMGCR, IL1B, VDR, CANT1
20mifepristone44 59 28 1112.6ESR1, IL1B, NCOA1
211,25 dihydroxy vitamin d3449.5ENO2, PTH, VDR, NCOA1
22prostaglandin449.5CANT1, IL1B, PTH, ENO2
23vitamin d449.5NCOA1, VDR, PTH, ESR1
24indomethacin44 59 28 1112.3CANT1, NCOA1, IL1B, ENO2
25genistein44 28 59 2 11 2414.3ESR1, IL1B, VDR, NCOA1, CANT1
26methotrexate44 49 1111.3IL1B, HMGCR, ENO2, ESR1
27troglitazone44 28 59 1112.2VDR, IL1B, HMGCR
28cycloheximide449.2VDR, IL1B, HMGCR, PTH, ESR1
29arginine449.2PTH, HMGCR, VDR, NCOA1, WRN, CANT1
30adenylate449.2CANT1, WRN, VDR, PTH, ENO2
31docetaxel44 49 59 1112.2VDR, ENO2, ESR1
32actinomycin d449.2ESR1, HMGCR, IL1B, VDR
33testosterone44 59 11 2411.9ESR1, ENO2, PTH, VDR, NCOA1
34vegf448.9ESR1, ENO2, PTH, HMGCR, IL1B, KL
35dexamethasone44 49 28 1111.9VDR, IL1B, HMGCR, PTH, ENO2

GO Terms for genes affiliated with Spondylosis

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16Gene Ontology
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Biological processes related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mammary gland branching involved in pregnancyGO:0607459.7VDR, ESR1
2agingGO:0075689.4HMGCR, KL, WRN
3positive regulation of transcription from RNA polymerase II promoterGO:0459448.9ESR1, PTH, VDR, NCOA1, IL1B

Products for genes affiliated with Spondylosis

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Sources for Spondylosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet