MCID: SPN020
MIFTS: 60

Spondylosis malady

Bone diseases, Neuronal diseases categories
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Summaries for Spondylosis

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Wikipedia:65 Spondylosis is a term referring to degenerative osteoarthritis of the joints between the center of the... more...

MalaCards based summary: Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to spondylolisthesis and spinal stenosis. An important gene associated with Spondylosis is TSSK4 (testis-specific serine kinase 4), and among its related pathways are Vitamin D synthesis and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds doxercalciferol and paricalcitol have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Disease Ontology:8 An bone structure disease that involves degeneration between vertebra located in vertebral column.

Aliases & Classifications for Spondylosis

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Spondylosis, Aliases & Descriptions:

Name: Spondylosis 8 10 62
Spondylogenic Compression of Thoracic Spinal Cord 8 62
Spondylogenic Compression of Lumbar Spinal Cord 8 62
Lumbosacral Spondylosis Without Myelopathy 8 62
 
Lumbar Spondylosis with Myelopathy 8 62
Spondylosis with Myelopathy 8 62
Thoracic 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:2247
ICD9CM27 721.9
MeSH34 D055009
ICD1025 M47, M47.9

Related Diseases for Spondylosis

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Diseases related to Spondylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 844)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis31.2TSSK4
2spinal stenosis30.7TSSK4, COL6A1
3arteriosclerosis30.5HMGCR
4calcinosis30.4KL, PTH
5atherosclerosis30.4WRN, IL1B, HMGCR
6sarcoma30.4ENO2, WRN, VDR
7lumbar disc disease30.4VDR
8endometriosis30.3HMGCR, IL1B, ESR1
9osteomalacia30.2KL, PTH, VDR
10degenerative disc disease30.2IL1B
11parathyroid adenoma30.1PTH, VDR
12hypercalcemia29.9VDR, PTH
13multiple sclerosis29.9VDR, IL1B, HMGCR
14renal osteodystrophy29.9PTH, VDR
15rickets29.9PTH, VDR
16uremia29.8PTH, VDR
17hyperparathyroidism29.7VDR, PTH, KL
18arthritis29.7HMGCR, IL1B, VDR
19adenoma29.6ENO2, HMGCR, PTH, VDR
20osteosarcoma29.5ESR1, WRN, PTH, VDR
21diabetes mellitus29.5VDR, PTH, IL1B, HMGCR
22arthropathy29.5HMGCR, IL1B
23osteoporosis29.4VDR, PTH, WRN, ESR1, KL, HMGCR
24vascular disease29.4ENO2, IL1B, ESR1
25cervicitis11.2
26aneurysm11.1
27aortic aneurysm11.1
28thoracic aortic aneurysm11.1
29thoracic outlet syndrome11.1
30aortic disease10.8
31asphyxiating thoracic dystrophy10.7
32neurogenic thoracic outlet syndrome10.6
33esophagitis10.6
34thoracic cancer10.5
35pneumothorax10.5
36familial thoracic aortic aneurysm and dissection10.5
37hypervitaminosis d10.5KL
38lung cancer10.5
39meningocele10.5
40esophageal cancer10.5
41spontaneous pneumothorax10.4
42actinomycosis10.4
43mediastinitis10.4
44marfan syndrome10.4
45aortitis10.4
46aortic atherosclerosis10.4
47venous thoracic outlet syndrome10.4
48hemangioma10.4
49primary spontaneous pneumothorax10.4
50arterial thoracic outlet syndrome10.4

Graphical network of the top 20 diseases related to Spondylosis:



Diseases related to spondylosis

Symptoms for Spondylosis

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Drugs & Therapeutics for Spondylosis

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Drug clinical trials:

Search ClinicalTrials for Spondylosis

Search NIH Clinical Center for Spondylosis

Genetic Tests for Spondylosis

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Anatomical Context for Spondylosis

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MalaCards organs/tissues related to Spondylosis:

32
Spinal cord, Bone, Cortex, Testes, Dorsal root ganglion

FMA organs/tissues related to Spondylosis:

14
Vertebral column

Animal Models for Spondylosis or affiliated genes

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MGI Mouse Phenotypes related to Spondylosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8KL, ESR1, WRN, PTH, VDR
2MP:00053798.5VDR, PTH, WRN, ESR1, KL
3MP:00053908.3VDR, PTH, WRN, ESR1, IL1B, KL
4MP:00053858.2VDR, PTH, WRN, ESR1, IL1B, KL
5MP:00053848.1ENO2, KL, COL6A1, ESR1, WRN, VDR
6MP:00053877.9VDR, PTH, WRN, ESR1, IL1B, KL
7MP:00107687.0VDR, PTH, WRN, ESR1, IL1B, KL

Publications for Spondylosis

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Articles related to Spondylosis:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
The concomitance of cervical spondylosis and adult thoracolumbar spinal deformity. (24715867)
2014
2
Pregabalin and Radicular Pain Study (PARPS) for Cervical Spondylosis in a Multiracial Asian Population. (24400034)
2014
3
Clinical efficacy of Eranda Muladi Yapana Basti in the management of Kati Graha (Lumbar spondylosis). (24049403)
2013
4
Is there a difference in range of motion, neck pain, and outcomes in patients with ossification of posterior longitudinal ligament versus those with cervical spondylosis, treated with plated laminoplasty? (23815254)
2013
5
Long-term outcome of the Cloward procedure for single-level cervical degenerative spondylosis. Clinical and radiological assessment after a 22-year mean follow-up. (24114077)
2013
6
The optimized acupuncture treatment for neck pain caused by cervical spondylosis: a study protocol of a multicentre randomized controlled trial. (22776567)
2012
7
Differences between soft-disc herniation and spondylosis in cervical arthroplasty: CT-documented heterotopic ossification with minimum 2 years of follow-up. (22136390)
2012
8
Cervical spondylosis treated by acupuncture at Ligou (LR 5) combined with movement therapy. (20653167)
2010
9
A concomitant posterior approach improves fusion rates but not overall reoperation rates in multilevel cervical fusion for spondylosis. (19412017)
2009
10
Treatment of cervical spondylosis by puncturing both the local and distal points--a report of 76 cases. (17393622)
2007
11
Surgery for degenerative lumbar spondylosis: updated Cochrane Review. (16227895)
2005
12
Clinicoradiological review: dural arteriovenous fistula and cervical spondylosis mimicking multiple sclerosis. (15918949)
2005
13
Diaphragmatic paralysis caused by cervical spondylosis. Case report. (15945437)
2005
14
Acute brucella meningomyeloencephalo-spondylosis in a teenage male. (15843135)
2005
15
Syringomyelia caused by cervical spondylosis. (14963752)
2004
16
Dysphagia induced by a cervical osteophyte: a case report of cervical spondylosis. (15043799)
2004
17
Clinical and radiological correlates of severity and surgery-related outcome in cervical spondylosis. (11302619)
2001
18
Cervical spondylosis: contrast-enhanced magnetization transfer prepulsed 3D turbo field echo MR imaging. (10739561)
2000
19
Surgery for degenerative lumbar spondylosis. (10796435)
2000
20
Spinal cord MRI hyperintensities in cervical spondylosis: an ischemic pathogenesis? (10800263)
2000
21
A new surgical technique: open-window corpectomy in the treatment of ossification of the posterior longitudinal ligament and advanced cervical spondylosis: technical note. (10598719)
1999
22
Quantitative analysis of cerebrospinal fluid flow in patients with cervical spondylosis using cine phase-contrast magnetic resonance imaging. (10201303)
1999
23
Surgical outcome in patients with coexisting multiple sclerosis and spondylosis. (10442447)
1999
24
Ossification of the yellow ligament and spondylosis and/or ossification of the posterior longitudinal ligament of the thoracic and lumbar spine. (10382780)
1999
25
The efficacy and safety of eperisone in patients with cervical spondylosis: results of a randomized, double-blind, placebo-controlled trial. (10389124)
1999
26
Dynamic changes of the spinal canal in patients with cervical spondylosis at flexion and extension using magnetic resonance imaging. (9704283)
1998
27
Cervical spondylosis in paraplegic patients and analysis of the wheelchair driving action: a preliminary communication. (9392049)
1997
28
The comparison of a rapid screening MR protocol with a conventional MR protocol for lumbar spondylosis. (8610572)
1996
29
The role of distraction in improving the space available for the cord in cervical spondylosis. (7701388)
1995
30
Anatomical treatment of cervical spondylosis. (7842609)
1994
31
Pre- and postoperative motor conduction times, measured using magnetic stimulation, in patients with cervical spondylosis. (2397044)
1990
32
F-response frequency in motor neuron disease and cervical spondylosis. (3585384)
1987
33
Observation of 30 cases of cervical spondylosis treated by electro-acupuncture. (3497311)
1987
34
Radiculopathy in spondylosis/spondylolisthesis. The laminar/ligamentum flavum process. (2980607)
1986
35
"Open door" operation to raise the vertebral arch in myelopathy due to cervical spondylosis. (6735722)
1984
36
Surgery for myelopathy in cervical spondylosis: safety measures and preoperative factors related to outcome. (7394659)
1980
37
Retrospective study of cervical spondylosis treated by anterior interbody fusion (in 505 patients performed by the Cloward technique). (687852)
1978
38
Pathology and pathogenesis of lumbar spondylosis and stenosis. (741238)
1978
39
Spondylosis in the whale--an anatomicoradiological study of an osteophyte. (607394)
1977
40
A rational approach to cervical disk lesions and spondylosis. (957939)
1976
41
Treatment of cervical spondylosis. (1000216)
1976
42
Cervical spondylosis: most common cause of position and vibratory sense loss. (939424)
1976
43
Letter: Pathogenesis of myelopathy in cervical spondylosis. (48816)
1975
44
Cervical spondylosis. (1132207)
1975
45
Cervical spondylosis and pseudomyotonia. (4421040)
1974
46
Surgical treatment of cervical spondylosis. (4668426)
1972
47
A set of new instruments for lumbar spondylosis. (5073270)
1972
48
The posterior operation in treatment of cervical spondylosis with myelopathy: a long-term follow-up study. (5096553)
1971
49
Athetoid movements in cervical spondylosis. (5427424)
1970
50
The patient with cervical spondylosis. (5207601)
1969

Variations for Spondylosis

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Expression for genes affiliated with Spondylosis

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Expression patterns in normal tissues for genes affiliated with Spondylosis

Search GEO for disease gene expression data for Spondylosis.

Pathways for genes affiliated with Spondylosis

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Compounds for genes affiliated with Spondylosis

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Compounds related to Spondylosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1doxercalciferol4410.2VDR, PTH
2paricalcitol44 1111.2PTH, VDR
37-dehydrocholesterol44 2411.1HMGCR, VDR
4deoxypyridinoline4410.1PTH, VDR
5lactone4410.1VDR, HMGCR
6thiazide4410.1HMGCR, VDR
7etidronic acid44 50 1112.0IL1B, VDR
8bisphosphonates5010.0VDR, IL1B
925-hydroxyvitamin d4410.0PTH, VDR
10clodronate44 50 1112.0VDR, IL1B
11phosphorus4410.0PTH, VDR
12naringenin44 1110.9ESR1, HMGCR
13xbai449.9VDR, ESR1
14risedronate44 50 28 61 1113.9IL1B, ESR1
15eb 108944 6110.9ESR1, VDR
16bicalutamide44 61 1111.8ESR1, VDR
17thyroxine44 2410.8HMGCR, PTH, VDR
18chenodeoxycholic acid44 28 24 1112.8VDR, HMGCR
19leflunomide44 50 1111.8ESR1, IL1B
20il 10449.8VDR, IL1B
21flutamide44 61 1111.7ESR1, ENO2
22alendronate44 50 1111.7ESR1, PTH, VDR
231,25 dihydroxy vitamin d3449.7ENO2, PTH, VDR
24calcitriol44 61 24 1112.7VDR, PTH, IL1B
25troglitazone44 28 61 1112.7HMGCR, IL1B, VDR
26ibmx44 61 2811.6PTH, IL1B, ENO2
27diethylstilbestrol44 28 1111.6ENO2, ESR1
28prostaglandin449.6ENO2, IL1B, PTH
29aspirin44 50 28 2412.6HMGCR, IL1B, VDR
30ribonucleic acid449.5PTH, IL1B, ENO2
31tamoxifen44 50 28 1112.5ESR1, PTH, VDR
32vitamin d449.5VDR, PTH, ESR1
33mg 13244 6110.5IL1B, ESR1, VDR
34raloxifene44 50 28 1112.4ESR1, VDR
35docetaxel44 50 61 1112.4ENO2, ESR1, VDR
36magnesium44 24 1111.4PTH, WRN, TSSK4, ENO2
37arginine449.4HMGCR, WRN, PTH, VDR
38adenylate449.3VDR, PTH, WRN, ENO2
39creatinine449.3VDR, PTH, HMGCR, ENO2
40thymidine44 2410.2VDR, PTH, IL1B, ENO2
41forskolin44 50 1111.2ENO2, IL1B, PTH
42actinomycin d449.2VDR, ESR1, IL1B, HMGCR
43testosterone44 61 24 1112.1ENO2, ESR1, PTH, VDR
44methotrexate50 44 1111.0ENO2, HMGCR, IL1B, ESR1
45cycloheximide448.9VDR, PTH, ESR1, IL1B, HMGCR
46dexamethasone44 50 28 1111.9VDR, PTH, IL1B, HMGCR, ENO2
47estrogen448.8ENO2, ESR1, PTH, VDR
48cysteine448.7VDR, WRN, COL6A1, HMGCR
49retinoic acid44 249.6VDR, ESR1, IL1B, ENO2
50vegf448.5ENO2, PTH, ESR1, IL1B, KL, HMGCR

GO Terms for genes affiliated with Spondylosis

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Cellular components related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9ENO2, KL, IL1B, PTH
2extracellular regionGO:0055768.2KL, COL6A1, IL1B, PTH, C12orf39

Biological processes related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of bone mineralizationGO:0305019.8PTH, KL
2mammary gland branching involved in pregnancyGO:0607459.7ESR1, VDR
3negative regulation of MAP kinase activityGO:0434079.6HMGCR, IL1B
4agingGO:0075689.5HMGCR, KL, WRN
5positive regulation of nitric oxide biosynthetic processGO:0454299.5IL1B, ESR1
6positive regulation of transcription from RNA polymerase II promoterGO:0459448.5IL1B, ESR1, PTH, VDR

Molecular functions related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.5ESR1, VDR
2magnesium ion bindingGO:0002879.0ENO2, TSSK4, WRN

Products for genes affiliated with Spondylosis

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Sources for Spondylosis

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3CDC
13ExPASy
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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51PubMed
52QIAGEN
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