MCID: SPN020
MIFTS: 54

Spondylosis malady

Neuronal diseases category

Summaries for Spondylosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Spondylosis is a term referring to degenerative osteoarthritis of the joints between the center of the... more...

MalaCards: Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to lung cancer and atherosclerosis. An important gene associated with Spondylosis is TSSK4 (testis-specific serine kinase 4), and among its related pathways are Vitamin D2 (ergocalciferol) metabolism and RXR and RAR heterodimerization with other nuclear receptor. The compounds doxercalciferol and (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 An bone structure disease that involves degeneration between vertebra located in vertebral column.

Aliases & Classifications for Spondylosis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spondylosis 8 10 60
spondylogenic compression of thoracic spinal cord 8
spondylogenic compression of lumbar spinal cord 8
lumbosacral spondylosis without myelopathy 8
lumbar spondylosis with myelopathy 8
spondylosis with myelopathy 8
thoracic 8


External Ids:

Disease Ontology8 DOID:2247
ICD9CM27 721.9
MeSH34 D055009
ICD1025 M47, M47.9

Related Diseases for Spondylosis

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17GeneCards, 18GeneDecks
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Diseases related to Spondylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 710)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.7ENO2
2atherosclerosis30.5IL1B, WRN, HMGCR
3osteoarthritis30.4IL1B, VDR
4endometriosis30.4IL1B, HMGCR, ESR1
5radiculopathy30.4COL6A1
6spondylolisthesis30.3TSSK4
7hyperostosis30.3COL6A1
8spinal stenosis30.3TSSK4, COL6A1
9vascular disease30.3IL1B, ENO2, ESR1
10hypertension30.2PTH
11multiple sclerosis30.2VDR, HMGCR, IL1B
12meningitis30.2IL1B
13osteoporosis30.1VDR, HMGCR, PTH, ESR1, KL, WRN
14adenocarcinoma30.0NCOA1, ESR1, ENO2, HMGCR
15rheumatoid arthritis30.0IL1B, HMGCR
16osteomalacia30.0VDR, PTH, KL
17arthritis30.0HMGCR, VDR, IL1B
18peritonitis29.9IL1B
19astrocytoma29.9IL1B
20diabetes mellitus29.9VDR, IL1B, HMGCR, PTH
21arteriosclerosis29.8HMGCR
22hypercalcemia29.7PTH, VDR
23degenerative disc disease29.7IL1B
24adenoma29.7PTH, HMGCR, VDR, ENO2
25osteosarcoma29.7PTH, VDR, WRN, ESR1
26breast cancer29.7ESR1, CANT1, PTH, VDR, NCOA1, WRN
27stroke, ischemic29.5CANT1
28prostatitis29.5VDR
29pheochromocytoma29.5ENO2
30infertility29.5ESR1
31rickets29.5PTH, VDR
32rhabdomyosarcoma29.5ENO2, NCOA1
33uremia29.5VDR, PTH
34cervicitis11.2
35thoracic aortic aneurysm11.1
36aortic aneurysm11.1
37thoracic outlet syndrome11.0
38aortic disease10.7
39thoracic cancer10.7
40asphyxiating thoracic dystrophy10.7
41dissecting aortic aneurysm10.6
42ruptured thoracic aortic aneurysm10.6
43ruptured aortic aneurysm10.6
44esophagitis10.6
45spinal cord ischemia10.5
46pneumothorax10.5
47esophageal cancer10.4
48meningocele10.4
49familial thoracic aortic aneurysm and dissection10.4
50actinomycosis10.4

Graphical network of the top 20 diseases related to Spondylosis:



Diseases related to spondylosis

Clinical Features for Spondylosis

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Drugs & Therapeutics for Spondylosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Spondylosis

Drug clinical trials:

Search ClinicalTrials for Spondylosis

Search NIH Clinical Center for Spondylosis

Search CenterWatch for Spondylosis

Genetic Tests for Spondylosis

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Anatomical Context for Spondylosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Spondylosis:

32
Spinal cord, Bone, Cortex, Testes, Dorsal root ganglion

FMA organs/tissues related to Spondylosis:

14
Vertebral column

Animal Models for Spondylosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spondylosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.0WRN, KL
2MP:00053908.1KL, WRN, NCOA1, VDR, IL1B, PTH
3MP:00053797.9BOLL, KL, WRN, NCOA1, VDR, PTH

Publications for Spondylosis

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50PubMed
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Articles related to Spondylosis:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
CORR Insights(Ar): Coexisting Lumbar Spondylosis in Patients Undergoing TKA: How Common and How Serious? (24136802)
2014
2
Long-term outcome of the Cloward procedure for single-level cervical degenerative spondylosis. Clinical and radiological assessment after a 22-year mean follow-up. (24114077)
2013
3
An unusual case of subclinical peripheral neuropathy and cervical spondylosis in atopic myelitis. (24251051)
2013
4
The optimized acupuncture treatment for neck pain caused by cervical spondylosis: a study protocol of a multicentre randomized controlled trial. (22776567)
2012
5
Anterior cervical discectomy and fusion without instrumentation for cervical spondylosis. (22828536)
2012
6
Kinetic magnetic resonance imaging analysis of lumbar segmental mobility in patients without significant spondylosis. (22674194)
2012
7
Anterior hybrid decompression and segmental fixation for adjacent three-level cervical spondylosis. (20809065)
2011
8
In vivo three-dimensional kinematics of the cervical spine during head rotation in patients with cervical spondylosis. (20683384)
2011
9
Spinal cord swelling with abnormal gadolinium-enhancement mimicking intramedullary tumors in cervical spondylosis patients: Three case reports and review of the literature. (22028753)
2010
10
Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. (19568689)
2009
11
Cervical degenerative index: a new quantitative radiographic scoring system for cervical spondylosis with interobserver and intraobserver reliability testing. (19384631)
2009
12
Prevalence of cervical spondylosis and musculoskeletal symptoms among coolies in a city of Bangladesh. (16484766)
2006
13
Acute brucella meningomyeloencephalo-spondylosis in a teenage male. (15843135)
2005
14
Surgery for degenerative lumbar spondylosis. (16235281)
2005
15
Surgery for degenerative lumbar spondylosis. (15846617)
2005
16
What is your diagnosis? Spondylosis of the lumbosacral junction. (15116884)
2004
17
Diagnosis and surgical management of disk herniations and cervical spondylosis using Tibone implants. (17675980)
2004
18
Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomes. (15314503)
2004
19
Cervical spondylosis: contrast-enhanced magnetization transfer prepulsed 3D turbo field echo MR imaging. (10739561)
2000
20
Spinal cord MRI hyperintensities in cervical spondylosis: an ischemic pathogenesis? (10800263)
2000
21
Cervical spondylosis in paraplegic patients and analysis of the wheelchair driving action: a preliminary communication. (9392049)
1997
22
Surgical treatment guided by spinal cord evoked potentials for tetraparesis due to cervical spondylosis. (7644264)
1995
23
Pathophysiology and rationale for treatment in lumbar spondylosis and instability. (8076475)
1994
24
Role of vitamin A and E in spondylosis. (1417666)
1992
25
Experimental spondylosis in the rabbit spine. Overuse could accelerate the spondylosis. (1566178)
1992
26
Thoracic spondylosis: experience of 4 cases. (1979601)
1990
27
Surgical treatment of myeloradiculopathy in cervical spondylosis. A report on 438 operations. (2594204)
1989
28
Lower cervical spondylosis and myelopathy in adults with Down's syndrome. (2973661)
1988
29
Cervical spondylosis and syringomyelia: suboptimal results, incomplete treatment, and the role of intraoperative ultrasound. (3288402)
1988
30
Exacerbated spinal neurologic deficit during sedation of a patient with cervical spondylosis. (3674497)
1987
31
Teaching round. Cervical spondylosis. (3444356)
1987
32
Four cases of dysphagia caused by anterior cervical spondylosis. (3453941)
1986
33
Dysphagia due to cervical spondylosis. (4056603)
1985
34
Osteoarthritis XI: Lumbar spondylosis. (2932620)
1985
35
The genetic factor in cervical spondylosis. (6538995)
1984
36
Long-term results in 102 cases of cervical myeloradiculopathy operated on for spondylosis and disc herniation. (6315632)
1983
37
Myelopathy and radiculopathy due to cervical spondylosis: myelographic-CT correlations. (6410808)
1983
38
Surgery for myelopathy in cervical spondylosis: safety measures and preoperative factors related to outcome. (7394659)
1980
39
Cervical myelopathy by spondylosis: limits and results of decompressive laminectomy. (7415885)
1980
40
Surgical management of cervical spondylosis. (472037)
1979
41
Scheuermann's disease or spinal osteochondrosis: its frequency and relationship with spondylosis. (154522)
1979
42
Rationale and techniques of posterior approaches to cervical disk lesions and spondylosis. (936012)
1976
43
Lumbar spondylosis and narrow spinal canal. (980195)
1976
44
Lumbar spondylosis and neuropathic bladder: investigation of 73 patients with chronic urinary symptoms. (1252890)
1976
45
Chapter 23. The management of cervical spondylosis. (4762815)
1973
46
Cervical spondylosis: a correlative clinico-radiological study. (4756927)
1973
47
Experimental spondylosis in rabbits as a local response to herniation of autogenous nucleus pulposus. (4655315)
1972
48
Results of cervical laminectomy with dural graft for severe spondylosis with narrow canal. (4679089)
1972
49
Cervical spondylosis presenting as the facial pain of temporomandibular joint disorder. (5658372)
1968
50
Hypervitaminosis A and deforming cervical spondylosis of the cat. (6030457)
1967

Genetic Variations for Spondylosis

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Expression for genes affiliated with Spondylosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spondylosis

Search GEO for disease gene expression data for Spondylosis.

Pathways for genes affiliated with Spondylosis

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Spondylosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Vitamin D2 (ergocalciferol) metabolism
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9.9PTH, VDR
29.9VDR, NCOA1
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.6PTH, IL1B, VDR
49.6ESR1, VDR, KL
59.5NCOA1, VDR, ESR1

Compounds for genes affiliated with Spondylosis

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Spondylosis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1doxercalciferol4410.3VDR, PTH
2(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol1110.3NCOA1, VDR
31,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)1110.3NCOA1, VDR
4paricalcitol44 1111.2PTH, VDR
5[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.2NCOA1, ESR1
6bisphosphonates4910.2VDR, IL1B
7etidronic acid44 49 1112.1VDR, IL1B
87-dehydrocholesterol44 2411.0VDR, HMGCR
9alendronate44 49 1112.0VDR, PTH, ESR1
10creatinine4410.0PTH, HMGCR, VDR
11chenodeoxycholic acid44 28 11 2412.9HMGCR, VDR, NCOA1
12bicalutamide44 59 1111.9NCOA1, VDR, ESR1
13tamoxifen44 49 28 1112.9PTH, VDR, NCOA1
14raloxifene44 28 49 1112.8ESR1, VDR, NCOA1
15risedronate44 59 49 28 1113.8ESR1, IL1B
164-hydroxytamoxifen449.7ESR1, VDR, NCOA1
17calcitriol44 59 11 2412.6NCOA1, VDR, IL1B, PTH
18diethylstilbestrol44 28 1111.6NCOA1, ENO2, ESR1
19aspirin44 49 28 2412.6HMGCR, IL1B, VDR, CANT1
20mifepristone44 59 28 1112.6ESR1, IL1B, NCOA1
211,25 dihydroxy vitamin d3449.5ENO2, PTH, VDR, NCOA1
22prostaglandin449.5CANT1, IL1B, PTH, ENO2
23vitamin d449.5NCOA1, VDR, PTH, ESR1
24indomethacin44 59 28 1112.3CANT1, NCOA1, IL1B, ENO2
25genistein44 28 59 2 11 2414.3ESR1, IL1B, VDR, NCOA1, CANT1
26methotrexate44 49 1111.3IL1B, HMGCR, ENO2, ESR1
27troglitazone44 28 59 1112.2VDR, IL1B, HMGCR
28cycloheximide449.2VDR, IL1B, HMGCR, PTH, ESR1
29arginine449.2PTH, HMGCR, VDR, NCOA1, WRN, CANT1
30adenylate449.2CANT1, WRN, VDR, PTH, ENO2
31docetaxel44 49 59 1112.2VDR, ENO2, ESR1
32actinomycin d449.2ESR1, HMGCR, IL1B, VDR
33testosterone44 59 11 2411.9ESR1, ENO2, PTH, VDR, NCOA1
34vegf448.9ESR1, ENO2, PTH, HMGCR, IL1B, KL
35dexamethasone44 49 28 1111.9VDR, IL1B, HMGCR, PTH, ENO2

GO Terms for genes affiliated with Spondylosis

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16Gene Ontology
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Biological processes related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mammary gland branching involved in pregnancyGO:0607459.7ESR1, VDR
2agingGO:0075689.4HMGCR, WRN, KL
3positive regulation of transcription from RNA polymerase II promoterGO:0459448.9VDR, IL1B, PTH, ESR1, NCOA1

Products for genes affiliated with Spondylosis

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  • Antibodies
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  • Lysates
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Sources for Spondylosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet