MCID: SPN020
MIFTS: 58

Spondylosis malady

Neuronal diseases, Bone diseases categories

Summaries for Spondylosis

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Wikipedia:65 Spondylosis is a term referring to degenerative osteoarthritis of the joints between the center of the... more...

MalaCards based summary: Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to atherosclerosis and spondylolisthesis. An important gene associated with Spondylosis is TSSK4 (testis-specific serine kinase 4), and among its related pathways are Vitamin D synthesis and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds doxercalciferol and paricalcitol have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Disease Ontology:10 An bone structure disease that involves degeneration between vertebra located in vertebral column.

Aliases & Classifications for Spondylosis

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Spondylosis, Aliases & Descriptions:

Name: Spondylosis 10 12 62
Spondylogenic Compression of Thoracic Spinal Cord 10 62
Spondylogenic Compression of Lumbar Spinal Cord 10 62
Lumbosacral Spondylosis Without Myelopathy 10 62
 
Lumbar Spondylosis with Myelopathy 10 62
Spondylosis with Myelopathy 10 62
Thoracic 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Bone diseases


External Ids:

Disease Ontology10 DOID:2247
ICD9CM29 721.9
MeSH35 D055009
ICD1027 M47, M47.9

Related Diseases for Spondylosis

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Diseases related to Spondylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 831)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.6WRN, IL1B, HMGCR
2spondylolisthesis30.5TSSK4
3endometriosis30.5HMGCR, IL1B, ESR1
4sarcoma30.5ENO2, WRN, VDR
5osteoporosis30.3VDR, PTH, ESR1
6arthritis30.2HMGCR, IL1B, VDR
7spinal stenosis30.2TSSK4, COL6A1
8osteomalacia30.2KL, PTH, VDR
9calcinosis30.0KL, PTH
10vascular disease29.9ENO2, IL1B, ESR1
11arteriosclerosis29.9HMGCR
12parathyroid adenoma29.8PTH, VDR
13hypercalcemia29.8VDR, PTH
14kidney disease29.8KL, IL1B, VDR
15adenoma29.8ENO2, HMGCR, PTH, VDR
16renal osteodystrophy29.6PTH, VDR
17rickets29.6PTH, VDR
18uremia29.6PTH, VDR
19hyperparathyroidism29.6VDR, PTH, KL
20arthropathy29.6HMGCR, IL1B
21cervicitis11.2
22aneurysm11.1
23aortic aneurysm11.1
24thoracic aortic aneurysm11.1
25thoracic outlet syndrome11.1
26aortic disease10.8
27asphyxiating thoracic dystrophy10.8
28neurogenic thoracic outlet syndrome10.7
29esophagitis10.6
30thoracic cancer10.5
31pneumothorax10.5
32lung cancer10.5
33familial thoracic aortic aneurysm and dissection10.5
34meningocele10.5
35spontaneous pneumothorax10.5
36esophageal cancer10.5
37actinomycosis10.4
38mediastinitis10.4
39venous thoracic outlet syndrome10.4
40marfan syndrome10.4
41aortitis10.4
42osteoarthritis10.4
43syringomyelia10.4
44aortic atherosclerosis10.4
45hemangioma10.4
46arterial thoracic outlet syndrome10.4
47ischemic heart disease10.4
48radiculopathy10.4
49hyperostosis10.4
50intracranial hypotension10.3

Graphical network of the top 20 diseases related to Spondylosis:



Diseases related to spondylosis

Symptoms for Spondylosis

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Drugs & Therapeutics for Spondylosis

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Drug clinical trials:

Search ClinicalTrials for Spondylosis

Search NIH Clinical Center for Spondylosis

Genetic Tests for Spondylosis

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Anatomical Context for Spondylosis

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MalaCards organs/tissues related to Spondylosis:

33
Spinal cord, Bone, Cortex, Testes, Dorsal root ganglion

FMA organs/tissues related to Spondylosis:

16
Vertebral column

Animal Models for Spondylosis or affiliated genes

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MGI Mouse Phenotypes related to Spondylosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8KL, ESR1, WRN, PTH, VDR
2MP:00053798.5VDR, PTH, WRN, ESR1, KL
3MP:00053908.3VDR, PTH, WRN, ESR1, IL1B, KL
4MP:00053858.2VDR, PTH, WRN, ESR1, IL1B, KL
5MP:00053848.1ENO2, KL, COL6A1, ESR1, WRN, VDR
6MP:00053877.9VDR, PTH, WRN, ESR1, IL1B, KL
7MP:00107687.0VDR, PTH, WRN, ESR1, IL1B, KL

Publications for Spondylosis

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Articles related to Spondylosis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Persistent Outpatient Hypertension is Independently Associated with Spinal Cord Dysfunction and Imaging Characteristics of Spinal Cord Damage among Patients with Cervical Spondylosis. (25819526)
2015
2
The concomitance of cervical spondylosis and adult thoracolumbar spinal deformity. (24715867)
2014
3
Pregabalin and Radicular Pain Study (PARPS) for Cervical Spondylosis in a Multiracial Asian Population. (24400034)
2014
4
Syringomyelia secondary to cervical spondylosis: Case report and review of literature. (25540552)
2014
5
Clinical efficacy of Eranda Muladi Yapana Basti in the management of Kati Graha (Lumbar spondylosis). (24049403)
2013
6
Is there a difference in range of motion, neck pain, and outcomes in patients with ossification of posterior longitudinal ligament versus those with cervical spondylosis, treated with plated laminoplasty? (23815254)
2013
7
Long-term outcome of the Cloward procedure for single-level cervical degenerative spondylosis. Clinical and radiological assessment after a 22-year mean follow-up. (24114077)
2013
8
The optimized acupuncture treatment for neck pain caused by cervical spondylosis: a study protocol of a multicentre randomized controlled trial. (22776567)
2012
9
Differences between soft-disc herniation and spondylosis in cervical arthroplasty: CT-documented heterotopic ossification with minimum 2 years of follow-up. (22136390)
2012
10
Cervical spondylosis treated by acupuncture at Ligou (LR 5) combined with movement therapy. (20653167)
2010
11
A concomitant posterior approach improves fusion rates but not overall reoperation rates in multilevel cervical fusion for spondylosis. (19412017)
2009
12
Treatment of cervical spondylosis by puncturing both the local and distal points--a report of 76 cases. (17393622)
2007
13
Surgery for degenerative lumbar spondylosis: updated Cochrane Review. (16227895)
2005
14
Clinicoradiological review: dural arteriovenous fistula and cervical spondylosis mimicking multiple sclerosis. (15918949)
2005
15
Diaphragmatic paralysis caused by cervical spondylosis. Case report. (15945437)
2005
16
Syringomyelia caused by cervical spondylosis. (14963752)
2004
17
Dysphagia induced by a cervical osteophyte: a case report of cervical spondylosis. (15043799)
2004
18
Clinical and radiological correlates of severity and surgery-related outcome in cervical spondylosis. (11302619)
2001
19
Cervical spondylosis: contrast-enhanced magnetization transfer prepulsed 3D turbo field echo MR imaging. (10739561)
2000
20
Surgery for degenerative lumbar spondylosis. (10796435)
2000
21
A new surgical technique: open-window corpectomy in the treatment of ossification of the posterior longitudinal ligament and advanced cervical spondylosis: technical note. (10598719)
1999
22
Quantitative analysis of cerebrospinal fluid flow in patients with cervical spondylosis using cine phase-contrast magnetic resonance imaging. (10201303)
1999
23
Surgical outcome in patients with coexisting multiple sclerosis and spondylosis. (10442447)
1999
24
Ossification of the yellow ligament and spondylosis and/or ossification of the posterior longitudinal ligament of the thoracic and lumbar spine. (10382780)
1999
25
The efficacy and safety of eperisone in patients with cervical spondylosis: results of a randomized, double-blind, placebo-controlled trial. (10389124)
1999
26
Dynamic changes of the spinal canal in patients with cervical spondylosis at flexion and extension using magnetic resonance imaging. (9704283)
1998
27
Cervical spondylosis in paraplegic patients and analysis of the wheelchair driving action: a preliminary communication. (9392049)
1997
28
The comparison of a rapid screening MR protocol with a conventional MR protocol for lumbar spondylosis. (8610572)
1996
29
The role of distraction in improving the space available for the cord in cervical spondylosis. (7701388)
1995
30
Anatomical treatment of cervical spondylosis. (7842609)
1994
31
Pre- and postoperative motor conduction times, measured using magnetic stimulation, in patients with cervical spondylosis. (2397044)
1990
32
F-response frequency in motor neuron disease and cervical spondylosis. (3585384)
1987
33
Observation of 30 cases of cervical spondylosis treated by electro-acupuncture. (3497311)
1987
34
Radiculopathy in spondylosis/spondylolisthesis. The laminar/ligamentum flavum process. (2980607)
1986
35
"Open door" operation to raise the vertebral arch in myelopathy due to cervical spondylosis. (6735722)
1984
36
Surgery for myelopathy in cervical spondylosis: safety measures and preoperative factors related to outcome. (7394659)
1980
37
Retrospective study of cervical spondylosis treated by anterior interbody fusion (in 505 patients performed by the Cloward technique). (687852)
1978
38
Pathology and pathogenesis of lumbar spondylosis and stenosis. (741238)
1978
39
Spondylosis in the whale--an anatomicoradiological study of an osteophyte. (607394)
1977
40
A rational approach to cervical disk lesions and spondylosis. (957939)
1976
41
Treatment of cervical spondylosis. (1000216)
1976
42
Cervical spondylosis: most common cause of position and vibratory sense loss. (939424)
1976
43
Letter: Pathogenesis of myelopathy in cervical spondylosis. (48816)
1975
44
Cervical spondylosis. (1132207)
1975
45
Cervical spondylosis and pseudomyotonia. (4421040)
1974
46
Surgical treatment of cervical spondylosis. (4668426)
1972
47
A set of new instruments for lumbar spondylosis. (5073270)
1972
48
The posterior operation in treatment of cervical spondylosis with myelopathy: a long-term follow-up study. (5096553)
1971
49
Athetoid movements in cervical spondylosis. (5427424)
1970
50
The patient with cervical spondylosis. (5207601)
1969

Variations for Spondylosis

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Expression for genes affiliated with Spondylosis

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Search GEO for disease gene expression data for Spondylosis.

Pathways for genes affiliated with Spondylosis

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Compounds for genes affiliated with Spondylosis

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Compounds related to Spondylosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1doxercalciferol4510.2VDR, PTH
2paricalcitol45 1311.2PTH, VDR
37-dehydrocholesterol45 2611.1HMGCR, VDR
4deoxypyridinoline4510.1PTH, VDR
5lactone4510.1VDR, HMGCR
6thiazide4510.1HMGCR, VDR
7etidronic acid45 51 1312.0IL1B, VDR
8bisphosphonates5110.0VDR, IL1B
925-hydroxyvitamin d4510.0PTH, VDR
10clodronate45 51 1312.0VDR, IL1B
11phosphorus4510.0PTH, VDR
12naringenin45 1310.9ESR1, HMGCR
13xbai459.9VDR, ESR1
14risedronate45 51 30 61 1313.9IL1B, ESR1
15eb 108945 6110.9ESR1, VDR
16bicalutamide45 61 1311.8ESR1, VDR
17thyroxine45 2610.8HMGCR, PTH, VDR
18chenodeoxycholic acid45 30 26 1312.8VDR, HMGCR
19leflunomide45 51 1311.8ESR1, IL1B
20il 10459.8VDR, IL1B
21flutamide45 61 1311.7ESR1, ENO2
22alendronate45 51 1311.7ESR1, PTH, VDR
231,25 dihydroxy vitamin d3459.7ENO2, PTH, VDR
24calcitriol45 61 26 1312.7VDR, PTH, IL1B
25troglitazone45 30 61 1312.7HMGCR, IL1B, VDR
26ibmx45 61 3011.6PTH, IL1B, ENO2
27diethylstilbestrol45 30 1311.6ENO2, ESR1
28prostaglandin459.6ENO2, IL1B, PTH
29aspirin45 51 30 2612.6HMGCR, IL1B, VDR
30ribonucleic acid459.5PTH, IL1B, ENO2
31tamoxifen45 51 30 1312.5ESR1, PTH, VDR
32vitamin d459.5VDR, PTH, ESR1
33mg 13245 6110.5IL1B, ESR1, VDR
34raloxifene45 51 30 1312.4ESR1, VDR
35docetaxel45 51 61 1312.4ENO2, ESR1, VDR
36magnesium45 26 1311.4PTH, WRN, TSSK4, ENO2
37arginine459.4HMGCR, WRN, PTH, VDR
38adenylate459.3VDR, PTH, WRN, ENO2
39creatinine459.3VDR, PTH, HMGCR, ENO2
40thymidine45 2610.2VDR, PTH, IL1B, ENO2
41forskolin45 51 1311.2ENO2, IL1B, PTH
42actinomycin d459.2VDR, ESR1, IL1B, HMGCR
43testosterone45 61 26 1312.1ENO2, ESR1, PTH, VDR
44methotrexate51 45 1311.0ENO2, HMGCR, IL1B, ESR1
45cycloheximide458.9VDR, PTH, ESR1, IL1B, HMGCR
46dexamethasone45 51 30 1311.9VDR, PTH, IL1B, HMGCR, ENO2
47estrogen458.8ENO2, ESR1, PTH, VDR
48cysteine458.7VDR, WRN, COL6A1, HMGCR
49retinoic acid45 269.6VDR, ESR1, IL1B, ENO2
50vegf458.5ENO2, PTH, ESR1, IL1B, KL, HMGCR

GO Terms for genes affiliated with Spondylosis

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Cellular components related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.9ENO2, KL, IL1B, PTH
2extracellular regionGO:00055768.2KL, COL6A1, IL1B, PTH, C12orf39

Biological processes related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of bone mineralizationGO:00305019.8PTH, KL
2mammary gland branching involved in pregnancyGO:00607459.7ESR1, VDR
3negative regulation of MAP kinase activityGO:00434079.6HMGCR, IL1B
4agingGO:00075689.5HMGCR, KL, WRN
5positive regulation of nitric oxide biosynthetic processGO:00454299.5IL1B, ESR1
6positive regulation of transcription from RNA polymerase II promoterGO:00459448.5IL1B, ESR1, PTH, VDR

Molecular functions related to Spondylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:00037079.5ESR1, VDR
2magnesium ion bindingGO:00002879.0ENO2, TSSK4, WRN

Products for genes affiliated with Spondylosis

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Sources for Spondylosis

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31KEGG
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40NCIt
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