MCID: SPN340
MIFTS: 28

Spontaneous Intracranial Hypotension

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Spontaneous Intracranial Hypotension

MalaCards integrated aliases for Spontaneous Intracranial Hypotension:

Name: Spontaneous Intracranial Hypotension 55
Cerebrospinal Fluid Leak, Spontaneous 69
Spontaneous Cerebrospinal Fluid Leak 55
Intracranial Hypotension, Essential 69

Characteristics:

Orphanet epidemiological data:

55
spontaneous intracranial hypotension
Inheritance: Not applicable;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA443180
UMLS via Orphanet 70 C3544264 C0751731 C3850067
ICD10 via Orphanet 33 G96.0

Summaries for Spontaneous Intracranial Hypotension

MalaCards based summary : Spontaneous Intracranial Hypotension, also known as cerebrospinal fluid leak, spontaneous, is related to intracranial hypotension and headache. The drugs Fibrin Tissue Adhesive and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pituitary.

Wikipedia : 72 A spontaneous cerebrospinal fluid leak (SCSFL) is a medical condition in which the cerebrospinal fluid... more...

Related Diseases for Spontaneous Intracranial Hypotension

Diseases related to Spontaneous Intracranial Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 intracranial hypotension 11.1
2 headache 10.6
3 thrombosis 10.4
4 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.4
5 cerebrospinal fluid leak 10.3
6 cerebritis 10.3
7 cervicitis 10.2
8 thrombophilia due to thrombin defect 10.2
9 aneurysm 10.0
10 neuropathy 10.0
11 intracranial hypertension 10.0
12 meningitis 10.0
13 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
14 cranial nerve palsy 10.0
15 thunderclap headache 10.0
16 siderosis 10.0
17 frontotemporal dementia 10.0
18 tremor 10.0
19 stroke, ischemic 10.0
20 superficial siderosis 10.0
21 patulous eustachian tube 10.0
22 episodic pain syndrome, familial, 1 10.0
23 dementia 10.0
24 marfan syndrome 9.9
25 systemic lupus erythematosus 9.7
26 hyperprolactinemia 9.7
27 ehlers-danlos syndrome 9.7
28 polycystic kidney disease 9.7
29 scleroderma, familial progressive 9.7
30 bipolar disorder 9.7
31 syringomyelia 9.7
32 cough headache 9.7
33 strabismus 9.7
34 hydrocephalus 9.7
35 ependymoma 9.7
36 osteoarthritis 9.7
37 sagittal sinus thrombosis 9.7
38 tarlov cysts 9.7
39 trigeminal neuralgia 9.7
40 sensorineural hearing loss 9.7
41 pituitary adenoma 9.7
42 ataxia and polyneuropathy, adult-onset 9.7
43 radiculopathy 9.7
44 encephalopathy 9.7
45 aging 9.7
46 acute cervicitis 9.7
47 abducens nerve disease 9.7
48 kidney disease 9.7
49 intracranial aneurysm 9.7
50 adenoma 9.7

Graphical network of the top 20 diseases related to Spontaneous Intracranial Hypotension:



Diseases related to Spontaneous Intracranial Hypotension

Symptoms & Phenotypes for Spontaneous Intracranial Hypotension

Drugs & Therapeutics for Spontaneous Intracranial Hypotension

Drugs for Spontaneous Intracranial Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 2
2 Coagulants Phase 2
3 Hemostatics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
2 Spontaneous Intracranial Hypotension Treatment "SIHT" Recruiting NCT02261792
3 Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension Recruiting NCT03041441
4 Pituitary Function and Spontaneous Intracranial Hypotension Active, not recruiting NCT02603549

Search NIH Clinical Center for Spontaneous Intracranial Hypotension

Genetic Tests for Spontaneous Intracranial Hypotension

Anatomical Context for Spontaneous Intracranial Hypotension

MalaCards organs/tissues related to Spontaneous Intracranial Hypotension:

38
Brain, Spinal Cord, Pituitary, Kidney

Publications for Spontaneous Intracranial Hypotension

Articles related to Spontaneous Intracranial Hypotension:

(show top 50) (show all 440)
# Title Authors Year
1
Ossified ligamentum flavum of the thoracic spine presenting as spontaneous intracranial hypotension: case report. ( 29372863 )
2018
2
Spontaneous intracranial hypotension with chronic brain sagging causing foramen magnum CSF circulation disorder reversible after lumbar epidural blood patch. ( 29441482 )
2018
3
Prevalence of hyperdense paraspinal vein sign in patients with spontaneous intracranial hypotension without dural CSF leak on standard CT myelography. ( 29217497 )
2018
4
Noninvasive assessment of intracranial elastance and pressure in spontaneous intracranial hypotension by MRI. ( 29437266 )
2018
5
Spontaneous Intracranial Hypotension Induced Headaches and Onabotulinum Toxin A: A Case Report. ( 29103382 )
2018
6
Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension. ( 28043956 )
2017
7
Spontaneous Intracranial Hypotension: A Review and Introduction of an Algorithm For Management. ( 28192268 )
2017
8
Value of Targeted Epidural Blood Patch and Management of Subdural Hematoma in Spontaneous Intracranial Hypotension: Case Report and Review of the Literature. ( 27693247 )
2017
9
Misdiagnosis of Spontaneous Intracranial Hypotension as a Risk Factor for Subdural Hematoma. ( 28653430 )
2017
10
Intracranial structural alteration predicts treatment outcome in patients with spontaneous intracranial hypotension. ( 28110544 )
2017
11
Update on the Diagnosis and Treatment of Spontaneous Intracranial Hypotension. ( 28755201 )
2017
12
Simultaneous Surgical Decompression of Bilateral Subdural Hematoma and an Administration of Epidural Blood Patch for Spontaneous Intracranial Hypotension. ( 28538330 )
2017
13
Treatment and outcome of subdural hematoma in patients with spontaneous intracranial hypotension: a report of 35 cases. ( 29052799 )
2017
14
Spontaneous Intracranial Hypotension. ( 28969244 )
2017
15
Reversible Holmes' tremor due to spontaneous intracranial hypotension. ( 28754752 )
2017
16
Multilevel, ultra-large-volume epidural blood patch for the treatment of neurocognitive decline associated with spontaneous intracranial hypotension: case report. ( 28984516 )
2017
17
Spontaneous Intracranial Hypotension after Vestibular Schwannoma Resection Due to an Unexpected Pathology: Tarlov Cysts. ( 28652945 )
2017
18
Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension. ( 28681582 )
2017
19
Greater Occipital Nerve Treatment in the Management of Spontaneous Intracranial Hypotension Headache: A Case Report. ( 28466552 )
2017
20
Spontaneous Intracranial Hypotension Presenting as a "Pseudo-Chiari 1. ( 28357166 )
2017
21
Spontaneous intracranial hypotension diagnosed as Chiari I malformation. ( 28348118 )
2017
22
CSF Venous Fistulas in Spontaneous Intracranial Hypotension: Imaging Characteristics on Dynamic and CT Myelography. ( 29023155 )
2017
23
Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? ( 28679427 )
2017
24
Quantitative Measurement of CSF in Patients with Spontaneous Intracranial Hypotension. ( 28385881 )
2017
25
Chiari-like displacement due to spontaneous intracranial hypotension in an adolescent: Successful treatment by epidural blood patch. ( 28283371 )
2017
26
Spinal meningeal diverticula, spontaneous intracranial hypotension, and superficial siderosis. ( 28130464 )
2017
27
Spontaneous Intracranial Hypotension With Site of Leak Detected Only After 111In-DTPA Cisternogram. ( 28079571 )
2017
28
Spontaneous intracranial hypotension: diagnosis to management. ( 26661291 )
2016
29
Pearls & Oy-sters: Spontaneous intracranial hypotension and posterior reversible encephalopathy syndrome. ( 26857956 )
2016
30
Epidural blood patch for spontaneous intracranial hypotension with chronic subdural haematoma: A case report and literature review. ( 27225863 )
2016
31
Management of spontaneous intracranial hypotension. ( 26837373 )
2016
32
Spontaneous intracranial hypotension following epidural anesthesia: a case report. ( 26939569 )
2016
33
Noncontrast Brain Computed Tomography Findings of Spontaneous Intracranial Hypotension in the Emergency Department Setting. ( 26763857 )
2016
34
Application of time-spatial labeling inversion pulse magnetic resonance imaging in the diagnosis of spontaneous intracranial hypotension due to high-flow cerebrospinal fluid leakage at C1-2. ( 28144490 )
2016
35
Spontaneous Intracranial Hypotension and its Association with Movement Disorders? ( 27897276 )
2016
36
Intraspinal hemorrhage in spontaneous intracranial hypotension: link to superficial siderosis? Report of 2 cases. ( 26588500 )
2016
37
A thin line between Meniere's disease and spontaneous intracranial hypotension syndrome. ( 26827704 )
2016
38
Spontaneous intracranial hypotension with pseudo-subarachnoid hemorrhage. ( 26943460 )
2016
39
Successful steroid treatment of coma induced by severe spontaneous intracranial hypotension. ( 27303109 )
2016
40
Early pain relief from orthostatic headache and hearing changes in spontaneous intracranial hypotension after epidural blood patch. ( 26908033 )
2016
41
Spontaneous intracranial hypotension caused by cervical CSF fistulae mimicking subarachnoid haemorrhage - a case report. ( 27341482 )
2016
42
Reply to: Spontaneous Intracranial Hypotension and its Association with Movement Disorders? ( 27905574 )
2016
43
Successful Treatment of Spontaneous Intracranial Hypotension by Plugging the CSF Leak with Percutaneous Cyanoacrylate Injection: A Report of Two Cases. ( 27113404 )
2016
44
Myelographic Techniques for the Detection of Spinal CSF Leaks in Spontaneous Intracranial Hypotension. ( 26700332 )
2016
45
Clinical characteristics of 15 cases of chronic subdural hematomas due to spontaneous intracranial hypotension with spinal cerebrospinal fluid leak. ( 26769700 )
2016
46
Atypical Presentations of Intracranial Hypotension: Comparison with Classic Spontaneous Intracranial Hypotension. ( 26939631 )
2016
47
Diagnosis and treatment of spontaneous intracranial hypotension due to cerebrospinal fluid leakage. ( 28066697 )
2016
48
Imaging Signs in Spontaneous Intracranial Hypotension: Prevalence and Relationship to CSF Pressure. ( 26869465 )
2016
49
Spontaneous Intracranial Hypotension: An Etiology for Consciousness Disorder and Coma. ( 27552236 )
2016
50
The usefulness of MDCT-myelography for patients with spontaneous intracranial hypotension. ( 27104112 )
2016

Variations for Spontaneous Intracranial Hypotension

Expression for Spontaneous Intracranial Hypotension

Search GEO for disease gene expression data for Spontaneous Intracranial Hypotension.

Pathways for Spontaneous Intracranial Hypotension

GO Terms for Spontaneous Intracranial Hypotension

Sources for Spontaneous Intracranial Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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