MCID: SPN033
MIFTS: 33

Spontaneous Ocular Nystagmus

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Spontaneous Ocular Nystagmus

MalaCards integrated aliases for Spontaneous Ocular Nystagmus:

Name: Spontaneous Ocular Nystagmus 12 14 69
Visual Deprivation Nystagmus 12
Searching Eye Movements 12
Nystagmus, Pathologic 41
Ocular Nystagmus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11771
ICD10 32 H55.03
ICD9CM 34 379.53
MeSH 41 D009759
UMLS 69 C0271384

Summaries for Spontaneous Ocular Nystagmus

MalaCards based summary : Spontaneous Ocular Nystagmus, also known as visual deprivation nystagmus, is related to pathologic nystagmus and gestational choriocarcinoma, and has symptoms including deficiencies of smooth pursuit movements An important gene associated with Spontaneous Ocular Nystagmus is FRMD7 (FERM Domain Containing 7), and among its related pathways/superpathways are Metabolism and DAG and IP3 signaling. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spontaneous Ocular Nystagmus

Graphical network of the top 20 diseases related to Spontaneous Ocular Nystagmus:



Diseases related to Spontaneous Ocular Nystagmus

Symptoms & Phenotypes for Spontaneous Ocular Nystagmus

UMLS symptoms related to Spontaneous Ocular Nystagmus:


deficiencies of smooth pursuit movements

GenomeRNAi Phenotypes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

25 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.5 CALB1 CALM2 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.5 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.5 POMC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.5 CALM2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.5 CALB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.5 CALB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 POMC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.5 POMC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.5 CALB1 CALM2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.5 POMC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.5 POMC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.5 CALB1

Drugs & Therapeutics for Spontaneous Ocular Nystagmus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Feasibility of Using Epicall for Monitoring Pre-seizure Biomarkers Unknown status NCT01436695

Search NIH Clinical Center for Spontaneous Ocular Nystagmus

Cochrane evidence based reviews: nystagmus, pathologic

Genetic Tests for Spontaneous Ocular Nystagmus

Anatomical Context for Spontaneous Ocular Nystagmus

MalaCards organs/tissues related to Spontaneous Ocular Nystagmus:

38
Eye

Publications for Spontaneous Ocular Nystagmus

Articles related to Spontaneous Ocular Nystagmus:

# Title Authors Year
1
Ginkgolide B accelerates vestibular compensation of spontaneous ocular nystagmus in guinea pig following unilateral labyrinthectomy. ( 7895826 )
1995
2
Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. ( 8491266 )
1993

Variations for Spontaneous Ocular Nystagmus

Expression for Spontaneous Ocular Nystagmus

Search GEO for disease gene expression data for Spontaneous Ocular Nystagmus.

Pathways for Spontaneous Ocular Nystagmus

Pathways related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 CALM1 CALM2 CALM3 CSPG5 FUT2 MED12
2
Show member pathways
12.96 CALM1 CALM2 CALM3 POMC
3
Show member pathways
12.92 CALM1 CALM2 CALM3 POMC
4
Show member pathways
12.76 CALM1 CALM2 CALM3 CSPG5
5
Show member pathways
12.67 CALM1 CALM2 CALM3
6
Show member pathways
12.66 CALM1 CALM2 CALM3 POMC
7
Show member pathways
12.43 CALM1 CALM2 CALM3
8
Show member pathways
12.43 CALM1 CALM2 CALM3 POMC
9
Show member pathways
12.42 CALM1 CALM2 CALM3
10
Show member pathways
12.41 CALM1 CALM2 CALM3
11
Show member pathways
12.39 CALM1 CALM2 CALM3
12
Show member pathways
12.34 CALM1 CALM2 CALM3
13
Show member pathways
12.33 CALM1 CALM2 CALM3
14
Show member pathways
12.32 CALM1 CALM2 CALM3
15
Show member pathways
12.31 CALM1 CALM2 CALM3
16
Show member pathways
12.3 CALM1 CALM2 CALM3
17
Show member pathways
12.29 CALM1 CALM2 CALM3
18
Show member pathways
12.28 CALM1 CALM2 CALM3
19 12.26 CALM1 CALM2 CALM3
20
Show member pathways
12.25 CALM1 CALM2 CALM3
21
Show member pathways
12.25 CALM1 CALM2 CALM3
22
Show member pathways
12.23 CALM1 CALM2 CALM3
23
Show member pathways
12.22 CALM1 CALM2 CALM3
24
Show member pathways
12.22 CALM1 CALM2 CALM3
25
Show member pathways
12.21 CALM1 CALM2 CALM3 POMC
26
Show member pathways
12.2 CALM1 CALM2 CALM3
27
Show member pathways
12.17 CALM1 CALM2 CALM3
28
Show member pathways
12.17 CALM1 CALM2 CALM3
29
Show member pathways
12.16 CALM1 CALM2 CALM3
30
Show member pathways
12.14 CALM1 CALM2 CALM3
31 12.13 CALM1 CALM2 CALM3
32
Show member pathways
12.11 CALM1 CALM2 CALM3
33
Show member pathways
12.09 CALM1 CALM2 CALM3
34
Show member pathways
12.09 CALM1 CALM2 CALM3
35
Show member pathways
12.07 CALM1 CALM2 CALM3
36 12.07 CALM1 CALM2 CALM3
37
Show member pathways
12.05 CALM1 CALM2 CALM3
38
Show member pathways
12.03 CALM1 CALM2 CALM3
39 12 CALM1 CALM2 CALM3
40 11.99 CALM1 CALM2 CALM3
41
Show member pathways
11.93 CALM1 CALM2 CALM3
42
Show member pathways
11.91 CALM1 CALM2 CALM3
43
Show member pathways
11.89 CALM1 CALM2 CALM3
44
Show member pathways
11.86 CALM1 CALM2 CALM3
45 11.84 CALM1 CALM2 CALM3
46 11.83 CALM1 CALM2 CALM3
47
Show member pathways
11.81 CALM1 CALM2 CALM3
48
Show member pathways
11.78 CALM1 CALM2 CALM3
49
Show member pathways
11.77 CALM1 CALM2 CALM3
50
Show member pathways
11.71 CALM1 CALM2 CALM3

GO Terms for Spontaneous Ocular Nystagmus

Cellular components related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.58 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.54 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
5 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
7 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
2 positive regulation of cAMP biosynthetic process GO:0030819 9.76 CALM1 CALM2 CALM3
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.75 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.74 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
7 regulation of cytokinesis GO:0032465 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein autophosphorylation GO:0031954 9.7 CALM1 CALM2 CALM3
9 positive regulation of protein dephosphorylation GO:0035307 9.69 CALM1 CALM2 CALM3
10 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.65 CALM1 CALM2 CALM3
12 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
13 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
14 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
15 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
16 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
17 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.43 CALM1 CALM2 CALM3
18 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.33 CALM1 CALM2 CALM3
19 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
20 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.78 CALB1 CALM1 CALM2 CALM3
2 protein domain specific binding GO:0019904 9.71 CALM1 CALM2 CALM3 MED12
3 ion channel binding GO:0044325 9.63 CALM1 CALM2 CALM3
4 disordered domain specific binding GO:0097718 9.54 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.5 CALM1 CALM2 CALM3
6 calcium channel inhibitor activity GO:0019855 9.43 CALM1 CALM2
7 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
8 adenylate cyclase binding GO:0008179 9.33 CALM1 CALM2 CALM3
9 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
10 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Spontaneous Ocular Nystagmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....