MCID: SPN033
MIFTS: 30

Spontaneous Ocular Nystagmus

Categories: Neuronal diseases, Eye diseases

Aliases & Classifications for Spontaneous Ocular Nystagmus

MalaCards integrated aliases for Spontaneous Ocular Nystagmus:

Name: Spontaneous Ocular Nystagmus 12 14 69
Visual Deprivation Nystagmus 12
Searching Eye Movements 12
Nystagmus, Pathologic 42
Ocular Nystagmus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11771
ICD10 33 H55.03
ICD9CM 35 379.53
MeSH 42 D009759
UMLS 69 C0271384

Summaries for Spontaneous Ocular Nystagmus

MalaCards based summary : Spontaneous Ocular Nystagmus, also known as visual deprivation nystagmus, is related to pathologic nystagmus and epicondylitis, and has symptoms including deficiencies of smooth pursuit movements An important gene associated with Spontaneous Ocular Nystagmus is FRMD7 (FERM Domain Containing 7), and among its related pathways/superpathways are Metabolism and DAG and IP3 signaling. Affiliated tissues include eye, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Spontaneous Ocular Nystagmus

Diseases related to Spontaneous Ocular Nystagmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
id Related Disease Score Top Affiliating Genes
1 pathologic nystagmus 11.3
2 epicondylitis 10.1 FUT2 MED12
3 subclavian steal syndrome 9.8 CALM1 CALM2 CALM3
4 long qt syndrome 15 9.8 CALM1 CALM2 CALM3
5 epidural spinal canal meningioma 9.8 CALM1 CALM2 CALM3
6 heterotaxy, visceral, 8, autosomal 9.8 CALM1 CALM2 CALM3
7 pseudohypoaldosteronism, type iic 9.8 CALM1 CALM2 CALM3
8 mononeuritis of lower limb 9.8 CALM1 CALM2 CALM3
9 pontiac fever 9.8 CALM1 CALM2 CALM3
10 dumping syndrome 9.8 CALM1 CALM2 CALM3
11 bulimia nervosa, age of onset of weight loss in 9.8 CALM1 CALM2 CALM3
12 leber congenital amaurosis 2 9.8 CALM1 CALM2 CALM3
13 alkhurma hemorrhagic fever 9.7 CALM1 CALM2 CALM3
14 cardiomyopathy, dilated, 1a 9.7 CALM1 CALM2 CALM3
15 cardiomyopathy, hypertrophic, 18 9.7 CALM1 CALM2 CALM3
16 partial of retinal vein occlusion 9.7 CALM1 CALM2 CALM3
17 plantar fasciitis 9.7 CALM1 CALM2 CALM3
18 encephalomalacia 9.7 CALM1 CALM3
19 deafness, autosomal dominant 2a 9.7 CALM1 CALM2 CALM3
20 lymphocytic choriomeningitis 9.6 CALM1 CALM2 CALM3
21 lateral medullary syndrome 9.6
22 hypochromic microcytic anemia 9.6 CALM1 CALM2 CALM3
23 pigment dispersion syndrome 9.6 CALM1 CALM2 CALM3
24 umbilical hernia 9.5 CALM1 CALM2 CALM3
25 jervell and lange-nielsen syndrome 9.5 CALM1 CALM2 CALM3
26 hairy cell leukemia 9.4 CALM1 CALM2 CALM3
27 regular astigmatism 6.8 CALB1 CALM1 CALM2 CALM3 CSPG5 FRMD7

Graphical network of the top 20 diseases related to Spontaneous Ocular Nystagmus:



Diseases related to Spontaneous Ocular Nystagmus

Symptoms & Phenotypes for Spontaneous Ocular Nystagmus

UMLS symptoms related to Spontaneous Ocular Nystagmus:


deficiencies of smooth pursuit movements

GenomeRNAi Phenotypes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.5 CALB1 CALM2 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.5 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.5 POMC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.5 CALM2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.5 CALB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.5 CALB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 POMC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.5 POMC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.5 CALB1 CALM2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.5 POMC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.5 POMC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.5 CALB1

Drugs & Therapeutics for Spontaneous Ocular Nystagmus

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety and Feasibility of Using Epicall for Monitoring Pre-seizure Biomarkers Unknown status NCT01436695

Search NIH Clinical Center for Spontaneous Ocular Nystagmus

Cochrane evidence based reviews: nystagmus, pathologic

Genetic Tests for Spontaneous Ocular Nystagmus

Anatomical Context for Spontaneous Ocular Nystagmus

MalaCards organs/tissues related to Spontaneous Ocular Nystagmus:

39
Eye

Publications for Spontaneous Ocular Nystagmus

Articles related to Spontaneous Ocular Nystagmus:

id Title Authors Year
1
Ginkgolide B accelerates vestibular compensation of spontaneous ocular nystagmus in guinea pig following unilateral labyrinthectomy. ( 7895826 )
1995
2
Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. ( 8491266 )
1993

Variations for Spontaneous Ocular Nystagmus

Expression for Spontaneous Ocular Nystagmus

Search GEO for disease gene expression data for Spontaneous Ocular Nystagmus.

Pathways for Spontaneous Ocular Nystagmus

Pathways related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CALM1 CALM2 CALM3 CSPG5 FUT2 MED12
2
Show member pathways
12.96 CALM1 CALM2 CALM3 POMC
3
Show member pathways
12.78 CALM1 CALM2 CALM3 POMC
4
Show member pathways
12.76 CALM1 CALM2 CALM3 CSPG5
5
Show member pathways
12.43 CALM1 CALM2 CALM3 POMC
6
Show member pathways
12.42 CALM1 CALM2 CALM3
7
Show member pathways
12.42 CALM1 CALM2 CALM3
8
Show member pathways
12.4 CALM1 CALM2 CALM3
9
Show member pathways
12.34 CALM1 CALM2 CALM3
10
Show member pathways
12.33 CALM1 CALM2 CALM3
11
Show member pathways
12.32 CALM1 CALM2 CALM3
12
Show member pathways
12.31 CALM1 CALM2 CALM3
13
Show member pathways
12.31 CALM1 CALM2 CALM3
14
Show member pathways
12.3 CALM1 CALM2 CALM3
15
Show member pathways
12.29 CALM1 CALM2 CALM3
16
Show member pathways
12.28 CALM1 CALM2 CALM3
17 12.26 CALM1 CALM2 CALM3
18
Show member pathways
12.25 CALM1 CALM2 CALM3
19
Show member pathways
12.24 CALM1 CALM2 CALM3
20
Show member pathways
12.23 CALM1 CALM2 CALM3
21
Show member pathways
12.22 CALM1 CALM2 CALM3
22
Show member pathways
12.22 CALM1 CALM2 CALM3
23
Show member pathways
12.2 CALM1 CALM2 CALM3
24
Show member pathways
12.2 CALM1 CALM2 CALM3 POMC
25
Show member pathways
12.16 CALM1 CALM2 CALM3
26
Show member pathways
12.16 CALM1 CALM2 CALM3
27
Show member pathways
12.15 CALM1 CALM2 CALM3
28
Show member pathways
12.13 CALM1 CALM2 CALM3
29 12.13 CALM1 CALM2 CALM3
30
Show member pathways
12.11 CALM1 CALM2 CALM3
31
Show member pathways
12.1 CALM1 CALM2 CALM3
32
Show member pathways
12.08 CALM1 CALM2 CALM3
33
Show member pathways
12.06 CALM1 CALM2 CALM3
34
Show member pathways
12.05 CALM1 CALM2 CALM3
35
Show member pathways
12.03 CALM1 CALM2 CALM3
36 12 CALM1 CALM2 CALM3
37 11.99 CALM1 CALM2 CALM3
38
Show member pathways
11.93 CALM1 CALM2 CALM3
39
Show member pathways
11.91 CALM1 CALM2 CALM3
40
Show member pathways
11.89 CALM1 CALM2 CALM3
41
Show member pathways
11.86 CALM1 CALM2 CALM3
42 11.84 CALM1 CALM2 CALM3
43 11.83 CALM1 CALM2 CALM3
44
Show member pathways
11.81 CALM1 CALM2 CALM3
45
Show member pathways
11.78 CALM1 CALM2 CALM3
46
Show member pathways
11.77 CALM1 CALM2 CALM3
47
Show member pathways
11.71 CALM1 CALM2 CALM3
48
Show member pathways
11.7 CALM1 CALM2 CALM3
49
Show member pathways
11.69 CALM1 CALM2 CALM3
50
Show member pathways
11.67 CALM1 CALM2 CALM3

GO Terms for Spontaneous Ocular Nystagmus

Cellular components related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.43 CALM1 CALM2 CALM3
2 spindle pole GO:0000922 9.33 CALM1 CALM2 CALM3
3 sarcomere GO:0030017 9.13 CALM1 CALM2 CALM3
4 calcium channel complex GO:0034704 8.8 CALM1 CALM2 CALM3

Biological processes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.74 CALM1 CALM2 CALM3
2 positive regulation of protein serine/threonine kinase activity GO:0071902 9.73 CALM1 CALM2 CALM3
3 regulation of heart rate GO:0002027 9.72 CALM1 CALM2 CALM3
4 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.71 CALM1 CALM2 CALM3
5 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
6 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.69 CALM1 CALM2 CALM3
7 positive regulation of protein autophosphorylation GO:0031954 9.67 CALM1 CALM2 CALM3
8 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.65 CALM1 CALM2 CALM3
9 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
10 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
11 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
12 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
13 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
14 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
15 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
16 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
17 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.62 CALB1 CALM1 CALM2 CALM3
2 ion channel binding GO:0044325 9.43 CALM1 CALM2 CALM3
3 protein serine/threonine kinase activator activity GO:0043539 9.33 CALM1 CALM2 CALM3
4 titin binding GO:0031432 9.13 CALM1 CALM2 CALM3
5 protein phosphatase activator activity GO:0072542 8.8 CALM1 CALM2 CALM3

Sources for Spontaneous Ocular Nystagmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....