MCID: SPN183
MIFTS: 44

Spontaneous Pneumothorax malady

Summaries for Spontaneous Pneumothorax

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33MalaCards
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MalaCards: Spontaneous Pneumothorax is related to tuberculosis and marfan syndrome. An important gene associated with Spontaneous Pneumothorax is FLCN (folliculin), and among its related pathways are Platelet degranulation and Heme Biosynthesis. The compounds pge2 and nadph have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Spontaneous Pneumothorax

Sources:
20GeneTests, 45Novoseek, 61UMLS
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Aliases & Descriptions:

spontaneous pneumothorax 20 45 61


Related Diseases for Spontaneous Pneumothorax

Sources:
17GeneCards, 18GeneDecks
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Diseases in the primary spontaneous pneumothorax family:

spontaneous pneumothorax familial type spontaneous pneumothorax

Diseases related to Spontaneous Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.5SERPINA1
2marfan syndrome30.4FBN1, CD36
3pulmonary disease, chronic obstructive30.2HMOX1, SERPINA1
4asthma30.2CCL11, LBP, SERPINA1, ELANE
5cystic fibrosis30.2LBP, HMOX1, SERPINA1, ELANE
6acute myocardial infarction30.0SERPINA1
7primary spontaneous pneumothorax11.2
8pulmonary edema10.6
9birt–hogg–dubé syndrome10.6
10birt-hogg-dub� syndrome10.6
11lymphangioleiomyomatosis10.5
12silicosis10.4
13wegener's granulomatosis10.3
14bronchiolitis10.3
15spontaneous tension pneumothorax10.3
16ankylosing spondylitis10.3
17birt-hogg-dube syndrome10.3
18miliary tuberculosis10.3
19spondylitis10.3
20catamenial pneumothorax10.3
21mitral valve prolapse10.2
22bronchiolitis obliterans10.2
23blastoma10.2
24tuberous sclerosis10.2
25pleuropulmonary blastoma10.2
26congenital diaphragmatic hernia10.2
27n syndrome10.2
28horner's syndrome10.2
29adenocarcinoma10.2
30aspergillosis10.2
31swyer syndrome10.2
32spontaneous pneumothorax familial type10.2
33swyer-james syndrome10.2
34pulmonary function10.2
35atrioventricular block10.0
36allergic bronchopulmonary aspergillosis10.0
37neurofibromatosis10.0
38bronchiolitis obliterans organizing pneumonia10.0
39severe acute respiratory syndrome10.0
40hemopneumothorax10.0
41diffuse scleroderma10.0
42langerhans cell sarcoma10.0
43papillary carcinoma10.0
44interstitial emphysema10.0
45pulmonary alveolar proteinosis10.0
46bone lymphoma10.0
47homocystinuria10.0
48rheumatoid lung disease10.0
49chickenpox10.0
50paracoccidioidomycosis10.0

Graphical network of the top 20 diseases related to Spontaneous Pneumothorax:



Diseases related to spontaneous pneumothorax

Clinical Features for Spontaneous Pneumothorax

Drugs & Therapeutics for Spontaneous Pneumothorax

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Spontaneous Pneumothorax

Drug clinical trials:

Search ClinicalTrials for Spontaneous Pneumothorax

Search NIH Clinical Center for Spontaneous Pneumothorax

Search CenterWatch for Spontaneous Pneumothorax

Genetic Tests for Spontaneous Pneumothorax

Sources:
20GeneTests
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Genetic tests related to Spontaneous Pneumothorax:

id Genetic test Affiliating Genes
1 Spontaneous Pneumothorax20 FLCN

Anatomical Context for Spontaneous Pneumothorax

Sources:
33MalaCards
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MalaCards organs/tissues related to Spontaneous Pneumothorax:

33
Bone marrow, Whole blood, Spleen, Colon, Kidney, Liver, Lung, Thyroid, Skin, Parietal lobe

Animal Models for Spontaneous Pneumothorax or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Spontaneous Pneumothorax

Sources:
51PubMed
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Articles related to Spontaneous Pneumothorax:

(show top 50)    (show all 625)
idTitleAuthorsYear
1
Efficacy of polyglycolic acid sheet after thoracoscopic bullectomy for spontaneous pneumothorax. (23623546)
2013
2
Surgery for secondary spontaneous pneumothorax: risk factors for recurrence and morbidity. (23674562)
2013
3
Awake thoracic surgery for secondary spontaneous pneumothorax: another advancement. (23140968)
2012
4
Climatic conditions and the onset of primary spontaneous pneumothorax: an investigation of the influence of solar terms. (22377483)
2012
5
What factors predict recurrence of a spontaneous pneumothorax? (23075329)
2012
6
Intrapleural instillation of autologous blood for persistent air leak in spontaneous pneumothorax in patients with advanced chronic obstructive pulmonary disease. (22459543)
2012
7
Comparative study of talc poudrage versus pleural abrasion for the treatment of primary spontaneous pneumothorax. (22514256)
2012
8
Recurrent spontaneous pneumothorax in a patient with Birt-Hogg-DubAc syndrome. (20692178)
2011
9
A rare cause of recurrent spontaneous pneumothorax. (21525091)
2011
10
Nonsteroidal antiinflammatory medications: efficient and safe treatment following video-assisted pleurodesis for spontaneous pneumothorax. (21882030)
2011
11
Spontaneous pneumothorax after chemotherapy for sarcoma with lung metastases: Case report and consideration of pathogenesis. (22263077)
2011
12
Awake single-access (uniportal) video-assisted thoracoscopic surgery for spontaneous pneumothorax. (21377698)
2011
13
The abnormal pattern of thorax in the patients with spontaneous pneumothorax coexists with blebs of the lungs: a commonly observed finding. (21608434)
2011
14
Spontaneous pneumothorax from cryptococcal pneumonia in systemic sclerosis: a case report. (21752256)
2011
15
An unusual cause of spontaneous pneumothorax. (22696702)
2011
16
Spontaneous Pneumothorax in an Allogeneic Cell Transplant Recipient with Invasive Pulmonary Aspergillosis and Antecedent RSV Pneumonitis. (21625303)
2011
17
Radiological predictors of recurrent primary spontaneous pneumothorax following non-surgical management. (20673650)
2010
18
Spontaneous feline pneumothorax caused by ruptured pulmonary bullae associated with possible bronchopulmonary dysplasia. (20194371)
2010
19
Screening for lymphangioleiomyomatosis by high-resolution computed tomography in young, nonsmoking women presenting with spontaneous pneumothorax is cost-effective. (20167846)
2010
20
Bilateral spontaneous pneumothorax in a newborn with N1303K mutation of cystic fibrosis (CFTR) gene. (20865572)
2010
21
Question 3. In patients with spontaneous pneumothorax, does treatment with oxygen increase resolution rate? (20457708)
2010
22
Pathophysiology, clinical evaluation and treatment options of spontaneous pneumothorax. (21038147)
2010
23
Simultaneous bilateral spontaneous pneumothorax in metastatic testicular cancer. (19140040)
2009
24
Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation. (19483054)
2009
25
Simultaneous bilateral spontaneous pneumothorax in an adult patient with cystic fibrosis. (19287925)
2009
26
Additional mechanical pleurodesis after thoracoscopic wedge resection and covering procedure for primary spontaneous pneumothorax. (18802734)
2009
27
Video-assisted thoracic surgery for recurrent primary spontaneous pneumothorax in reoperated chests. (19882315)
2009
28
Recurrent spontaneous pneumothorax during pregnancy: a case report. (19946557)
2009
29
Airlessness in airspace. Simultaneous occurrence of spontaneous pneumothorax with pneumomediastinum and pneumorrhachis: report of a case. (18085363)
2008
30
Uniportal video-assisted thoracic surgery for primary spontaneous pneumothorax: clinical and economic analysis in comparison to the traditional approach. (17984169)
2008
31
An open and shut case for early VATS treatment of primary spontaneous pneumothorax in children. (17568487)
2007
32
A 48-year-old woman with skin lesions, renal masses, and spontaneous pneumothorax. (17296671)
2007
33
Late onset of spontaneous pneumothorax complicating acute bronchiolitis in a 5-month-old infant: case report and literature review. (18091598)
2007
34
Use of computed tomography for evaluation of lung lesions associated with spontaneous pneumothorax in dogs: 12 cases (1999-2002). (16506938)
2006
35
Risk factors of spontaneous pneumothorax in Kuwait. (16888390)
2006
36
Video-assisted thoracoscopic surgery for recurrent spontaneous pneumothorax: the long-term benefit. (16479351)
2006
37
Simple sequential treatment for primary spontaneous pneumothorax: one step closer. (16507842)
2006
38
Familial spontaneous pneumothorax in neonates. (15973032)
2005
39
Spontaneous pneumothorax. (16135315)
2005
40
Familial spontaneous pneumothorax. (15955160)
2005
41
M-tip electro-ablation of pneumo-cysts for treatment of spontaneous pneumothorax as a secondary method to stapling: a confirmation study. (17670494)
2005
42
Prospective comparison between endosuturing and endostapling in treating primary spontaneous pneumothorax. (15630942)
2004
43
Thoracoscopic management of primary spontaneous pneumothorax. (12173891)
2002
44
Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-DubAc syndrome. (11927500)
2002
45
Manual aspiration: the preferred method for managing primary spontaneous pneumothorax? (11991864)
2002
46
Epidural emphysema associated with primary spontaneous pneumothorax. (11509299)
2001
47
Pleuropulmonary blastoma: report of a case presenting with spontaneous pneumothorax. (11300091)
2001
48
Primary spontaneous pneumothorax in two siblings suggests autosomal recessive inheritance. (11348979)
2001
49
Nonsmoking, non-alpha 1-antitrypsin deficiency-induced emphysema in nonsmokers with healed spontaneous pneumothorax, identified by computed tomography of the lungs. (8432133)
1993
50
Spontaneous pneumothorax complicating pulmonary mycetoma in patients with acute leukemia. (2385767)
1990

Genetic Variations for Spontaneous Pneumothorax

Expression for genes affiliated with Spontaneous Pneumothorax

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spontaneous Pneumothorax

Search GEO for disease gene expression data for Spontaneous Pneumothorax.

Pathways for genes affiliated with Spontaneous Pneumothorax

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5SERPINA1, CD36, SOD1
2
Hide members
9.1HMOX1, BLVRA
3
Hide members
9.1HMOX1, BLVRA

Compounds for genes affiliated with Spontaneous Pneumothorax

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pge24510.6CCL11
2nadph45 2411.4BLVRA
3luminol4510.3CCL11, SOD1
4alpha tocopherol4510.2ELANE, CD36
5psgag4510.1ELANE, CD36
6endotoxin4510.1LBP, FTMT
7(4-aminophenyl)mercuric acetate4510.1ELANE
8rotenone4510.0HMOX1
9dihydrolipoic acid45 1110.9SOD1, ELANE
10hocl459.9SERPINA1, ELANE, SOD1
11onoo459.9SOD1, SERPINA1
12peroxynitrite459.9CCL11, SOD1, SERPINA1
13desmosine459.8SERPINA1, ELANE, FBN1
14tannins459.8ELANE, CD36
15nitroglycerin45 1110.7SOD1, ELANE, HIF1A
16dexamethasone45 50 29 1112.7CCL11, LBP, HIF1A
17ptio459.6SOD1, HMOX1
18serine459.6LBP, BLVRA, FBN1
193-nitrotyrosine459.6SOD1, HMOX1
20ulinastatin459.5ELANE, SOD1
21hyaluronic acid45 2410.5ELANE, CD36, FBN1, CCL11
22superoxide45 2410.5HMOX1, ELANE, LBP
23alpha lipoic acid459.4HMOX1, SOD1, SERPINA1
24biliverdin45 2410.4HMOX1, BLVRA
2515-deoxy-delta-12,14-prostaglandin j2459.3CD36, HMOX1, CCL11
26deta nonoate459.3HMOX1, HIF1A
27rottlerin459.3ELANE, CD36, HMOX1
28trolox459.3HIF1A, SOD1, HMOX1
29gsno459.2HMOX1, HIF1A, SOD1
30s-nitroso-n-acetylpenicillamine459.2SOD1, HMOX1, HIF1A
31manganese superoxide459.2SOD1, HIF1A, HMOX1
32pdtc459.1SOD1, HMOX1, HIF1A
33heparin45 29 11 2411.9LBP, CCL11, FBN1, SERPINA1, ELANE, CD36
34sodium nitroprusside458.9HMOX1, HIF1A, SOD1, ELANE
35egcg458.9ELANE, HIF1A, HMOX1, SOD1
36n acetylcysteine458.9HIF1A, SOD1, HMOX1, CCL11
37deferoxamine45 119.8SOD1, FTMT, HMOX1, HIF1A
38sb 20358045 609.8CCL11, HIF1A, CD36, HMOX1
39iron45 249.8HIF1A, SERPINA1, HMOX1, FTMT
40resveratrol45 60 11 2411.7SOD1, HMOX1, HIF1A
41actinomycin d458.7LBP, HIF1A, CCL11, HMOX1
42ly294002458.7CD36, HIF1A, HMOX1, CCL11
43nitric oxide45 11 2410.4CCL11, HMOX1, SOD1, SERPINA1, HIF1A, LBP
44alanine458.3FBN1, HMOX1, HIF1A, LBP, SOD1, CCL11
45h2o2458.2SOD1, HIF1A, CD36, HMOX1, ELANE, SERPINA1
46ascorbic acid45 249.2HMOX1, CD36, SERPINA1, SOD1, HIF1A, FBN1
47retinoic acid45 249.1CCL11, HIF1A, FBN1, HMOX1, ELANE, CD36
48vegf458.1HMOX1, HIF1A, FBLN5, CD36, CCL11
49cysteine457.8SOD1, HIF1A, ELANE, SERPINA1, CD36, HMOX1
50oxygen45 248.5LBP, SERPINA1, BLVRA, ELANE, HMOX1, FTMT

GO Terms for genes affiliated with Spontaneous Pneumothorax

Sources:
16Gene Ontology
See all sources

Cellular components related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1FBLN5, FBN1, SOD1
2extracellular regionGO:0055767.6ELANE, CCL11, SOD1, LBP, FBN1, FBLN5
3extracellular spaceGO:0056157.3HMOX1, CCL11, SOD1, LBP, FBN1, FBLN5

Biological processes related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.0LBP, CD36
2negative regulation of growth of symbiont in hostGO:0441309.8LBP, CD36, ELANE
3regulation of removal of superoxide radicalsGO:20001219.7FBLN5, CD36
4negative regulation of TOR signaling cascadeGO:0320079.7FLCN, HIF1A
5platelet degranulationGO:0025769.7SERPINA1, SOD1, CD36
6positive regulation of chemokine productionGO:0327229.7HIF1A, LBP
7response to lipopolysaccharideGO:0324969.6LBP, ELANE, SERPINA1
8muscle cell cellular homeostasisGO:0467169.6HIF1A, SOD1
9low-density lipoprotein particle clearanceGO:0343839.5CD36, HMOX1
10regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:0436199.4HIF1A, HMOX1
11heme catabolic processGO:0421679.4BLVRA, HMOX1
12positive regulation of angiogenesisGO:0457669.0HIF1A, HMOX1, CCL11
13negative regulation of neuron apoptotic processGO:0435248.9HMOX1, HIF1A, SOD1
14porphyrin-containing compound metabolic processGO:0067788.8HMOX1, BLVRA
15cellular iron ion homeostasisGO:0068798.7FTMT, SOD1, HMOX1, HIF1A

Products for genes affiliated with Spontaneous Pneumothorax

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Sources for Spontaneous Pneumothorax

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet