MCID: SPN183
MIFTS: 52

Spontaneous Pneumothorax malady

Genetic diseases, Rare diseases, Respiratory diseases categories
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Summaries for Spontaneous Pneumothorax

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MalaCards based summary: Spontaneous Pneumothorax is related to pneumothorax and bronchiolitis. An important gene associated with Spontaneous Pneumothorax is FLCN (folliculin), and among its related pathways are IL-10 Pathway and Oxidative Stress. The compounds luminol and biliverdin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone marrow, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Spontaneous Pneumothorax

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Sources:
20GeneTests, 44Novoseek, 62UMLS
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Spontaneous Pneumothorax, Aliases & Descriptions:

Name: Spontaneous Pneumothorax 20 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


Related Diseases for Spontaneous Pneumothorax

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Diseases in the Primary Spontaneous Pneumothorax family:

Spontaneous Pneumothorax Familial Type spontaneous pneumothorax

Diseases related to Spontaneous Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1pneumothorax33.0FLCN
2bronchiolitis31.1CCL11
3chronic obstructive pulmonary disease30.7HMOX1, SERPINA1
4wegener's granulomatosis30.5SERPINA1, ELANE
5myocardial infarction30.4CCL11, HIF1A, LBP
6marfan syndrome30.4FBN1, CD36
7respiratory failure30.4ELANE, CCL11
8ankylosing spondylitis30.3FBN1, SERPINA1
9pneumonia30.2HMOX1, CCL11, ELANE, SERPINA1, LBP
10lung adenocarcinoma30.1HMOX1, SERPINA1, HIF1A
11asthma30.1LBP, SERPINA1, ELANE, CCL11
12pulmonary emphysema30.1SERPINA1, ELANE, HMOX1
13cystic fibrosis30.1HMOX1, ELANE, SERPINA1, LBP
14primary spontaneous pneumothorax11.2
15pulmonary edema10.6
16lymphangioleiomyomatosis10.5
17tuberculosis10.4
18malaria10.4CD36
19arthus reaction10.4ELANE
20silicosis10.4
21langerhans-cell histiocytosis10.4
22histiocytosis10.4
23miliary tuberculosis10.4
24lung cancer10.4
25acute intermittent porphyria10.3HMOX1, SOD1
26birt-hogg-dube syndrome10.3
27osteosarcoma10.3
28sarcoma10.3
29spondylitis10.3
30catamenial pneumothorax10.3
31vernal keratoconjunctivitis10.3CD36, CCL11
32cerebral malaria10.2CD36, HMOX1
33bronchopulmonary dysplasia10.2SOD1, ELANE
34alpha 1-antitrypsin deficiency10.2
35bronchiolitis obliterans10.2
36blastoma10.2
37mitral valve prolapse10.2
38tuberous sclerosis10.2
39pleuropulmonary blastoma10.2
40horner's syndrome10.2
41congenital diaphragmatic hernia10.2
42adenocarcinoma10.2
43aspergillosis10.2
44endometriosis10.2
45malignant pleural mesothelioma10.2
46pulmonary embolism10.2
47spontaneous pneumothorax familial type10.2
48pulmonary function10.2
49adult respiratory distress syndrome10.2ELANE, LBP
50arteriosclerosis10.2HMOX1, SOD1

Graphical network of the top 20 diseases related to Spontaneous Pneumothorax:



Diseases related to spontaneous pneumothorax

Symptoms for Spontaneous Pneumothorax

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Drugs & Therapeutics for Spontaneous Pneumothorax

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Drug clinical trials:

Search ClinicalTrials for Spontaneous Pneumothorax

Search NIH Clinical Center for Spontaneous Pneumothorax

Genetic Tests for Spontaneous Pneumothorax

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Genetic tests related to Spontaneous Pneumothorax:

id Genetic test Affiliating Genes
1 Spontaneous Pneumothorax20 FLCN

Anatomical Context for Spontaneous Pneumothorax

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MalaCards organs/tissues related to Spontaneous Pneumothorax:

32
Lung, Testes, Bone marrow, Bone, Spleen, Colon, Kidney, Liver, Thyroid, Skin

Animal Models for Spontaneous Pneumothorax or affiliated genes

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MGI Mouse Phenotypes related to Spontaneous Pneumothorax:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6LBP, HIF1A, SOD1, HMOX1, CD36
2MP:00053678.2FBN1, HIF1A, FLCN, HMOX1, CD36
3MP:00053888.1HMOX1, CCL11, HIF1A, FBLN5, FBN1
4MP:00053797.7FBN1, HIF1A, SOD1, HMOX1, CD36
5MP:00053697.7FBN1, FBLN5, HIF1A, SOD1, HMOX1, CD36
6MP:00053857.5FBN1, FBLN5, HIF1A, SOD1, FLCN, HMOX1
7MP:00053847.4FBN1, FBLN5, HIF1A, SOD1, FLCN, HMOX1
8MP:00107687.2CD36, HMOX1, ELANE, FLCN, SOD1, HIF1A
9MP:00053976.8CD36, LBP, FBN1, HIF1A, SOD1, FLCN
10MP:00053876.8LBP, FBN1, HIF1A, SOD1, FLCN, ELANE
11MP:00053766.7LBP, FBN1, FBLN5, HIF1A, SOD1, FLCN

Publications for Spontaneous Pneumothorax

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Articles related to Spontaneous Pneumothorax:

(show top 50)    (show all 630)
idTitleAuthorsYear
1
Detection of blebs and bullae in patients with primary spontaneous pneumothorax by multi-detector CT reconstruction using different slice thicknesses. (25196152)
2014
2
Spontaneous pneumothorax in ataxia telangectasia. (25297371)
2014
3
Video-assisted thoracoscopic surgery for postoperative recurrent primary spontaneous pneumothorax. (24455176)
2014
4
Birt-Hogg-DubAc syndrome in a patient presenting with familial spontaneous pneumothorax. (24996715)
2014
5
Vascular-penetration defect detected in parietal pleura of primary spontaneous pneumothorax. (25015539)
2014
6
Anesthesia under cardiopulmonary bypass for video assisted thoracoscopic wedge resection in patient with spontaneous pneumothorax and contralateral post-tuberculosis destroyed lung. (24024004)
2013
7
Sensitivity, positive predictive value, and interobserver variability of computed tomography in the diagnosis of bullae associated with spontaneous pneumothorax in dogs: 19 cases (2003-2012). (23822082)
2013
8
Prevalence, clinical manifestations and mortality rate in patients with spontaneous pneumothorax in Thammasat University Hospital. (24350409)
2013
9
Spontaneous pneumothorax with persistent air leakage and invasive procedures. (24088750)
2013
10
The Effect of Thoracoscopic Pleurodesis in Primary Spontaneous Pneumothorax: Apical Parietal Pleurectomy versus Pleural Abrasion. (23130305)
2012
11
Spontaneous pneumothorax and ozone levels: is there a relation? (22958437)
2011
12
Recurrent spontaneous pneumothorax in a patient with Birt-Hogg-DubAc syndrome. (20692178)
2011
13
An unusual cause of spontaneous pneumothorax: the Mounier-Kuhn syndrome. (21736094)
2011
14
A rare cause of recurrent spontaneous pneumothorax. (21525091)
2011
15
Efficacy of blood-patch pleurodesis for secondary spontaneous pneumothorax in interstitial lung disease. (21628929)
2011
16
Erlotinib treatment for persistent spontaneous pneumothorax in non-small cell lung cancer: a case report. (22166539)
2010
17
Chemotherapy-related delayed bilateral spontaneous pneumothorax and lung fibrosis: methotrexate or cyclophosphamide, or both? (20931743)
2010
18
Surgery for secondary spontaneous pneumothorax. (20453650)
2010
19
Radiological predictors of recurrent primary spontaneous pneumothorax following non-surgical management. (20673650)
2010
20
Percutaneous aspiration versus tube drainage for spontaneous pneumothorax: systematic review and meta-analysis. (20060735)
2010
21
Decision making in the management of secondary spontaneous pneumothorax in patients with severe emphysema. (19662966)
2009
22
Simultaneous bilateral spontaneous pneumothorax in metastatic testicular cancer. (19140040)
2009
23
Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia. (19385305)
2009
24
Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation. (19483054)
2009
25
A case of spontaneous pneumothorax presenting with high-degree atrioventricular block. (19729170)
2009
26
Video-assisted thoracoscopy for spontaneous pneumothorax after pneumonectomy. (18514025)
2009
27
Re-expansion pulmonary edema following treatment of spontaneous pneumothorax during oral surgery. (19462219)
2009
28
Spontaneous pneumothorax as a first sign of pulmonary carcinoma. (19566945)
2009
29
Anesthetic management of thoracotomy for spontaneous pneumothorax in a pregnant woman. (17693074)
2008
30
Thoracoscopic apico-posterior transmediastinal approach for bilateral spontaneous pneumothorax. (18187456)
2008
31
Should surgical pleurectomy for spontaneous pneumothorax be always thoracoscopic? (18407960)
2008
32
Does video-assisted thoracoscopic pleurectomy result in better outcomes than open pleurectomy for primary spontaneous pneumothorax? (18287119)
2008
33
Ipsilateral reexpansion pulmonary edema after drainage of a spontaneous pneumothorax: a case report. (17903268)
2007
34
Use of computed tomography for evaluation of lung lesions associated with spontaneous pneumothorax in dogs: 12 cases (1999-2002). (16506938)
2006
35
Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. (16376095)
2006
36
Aetiology and clinical profile of spontaneous pneumothorax in adults. (16970292)
2006
37
Thoracoscopic management of spontaneous pneumothorax during pregnancy. (16165137)
2005
38
Does a thoracic epidural confer any additional benefit following video-assisted thoracoscopic pleurectomy for primary spontaneous pneumothorax? (15784372)
2005
39
Physical fitness after apical resection for the treatment of primary spontaneous pneumothorax. (16261980)
2005
40
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. (15805188)
2005
41
Video-assisted thoracic surgery (VATS) for primary spontaneous pneumothorax: how I do it ? (16184724)
2005
42
Primary spontaneous pneumothorax in children: the role of CT in guiding management. (15767109)
2005
43
Evaluating the treatment options for spontaneous pneumothorax. (15311535)
2004
44
Results of thoracoscopic pleural abrasion for primary spontaneous pneumothorax. (14752638)
2004
45
Video-assisted thoracoscopic management of recurrent primary spontaneous pneumothorax after prior talc pleurodesis: a feasible, safe and efficient treatment option. (15519177)
2004
46
Role of chest CT scan in determining etiology of primary spontaneous pneumothorax. (12866634)
2003
47
Diagnosis of pulmonary lymphangioleiomyomatosis by HMB45 in surgically treated spontaneous pneumothorax. (8620956)
1995
48
Value of computed tomography of the lung in the management of primary spontaneous pneumothorax. (2063968)
1991
49
Chemical pleurodesis in primary spontaneous pneumothorax. (2763278)
1989
50
Recurrent spontaneous pneumothorax in diffuse scleroderma. Report of a case. (5907810)
1966

Variations for Spontaneous Pneumothorax

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Expression for genes affiliated with Spontaneous Pneumothorax

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Expression patterns in normal tissues for genes affiliated with Spontaneous Pneumothorax

Search GEO for disease gene expression data for Spontaneous Pneumothorax.

Pathways for genes affiliated with Spontaneous Pneumothorax

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Pathways related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HMOX1, BLVRA
29.7HMOX1, SOD1
3
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
9.6HMOX1, FTMT, BLVRA
4
Show member pathways
FOXA transcription factor networks37
9.4SOD1, SERPINA1
59.4CD36, ELANE
69.3SERPINA1, ELANE
7
Show member pathways
9.2FBLN5, FBN1
8
Show member pathways
8.9SERPINA1, SOD1, CD36
9
Show member pathways
8.7FBN1, FBLN5, ELANE

Compounds for genes affiliated with Spontaneous Pneumothorax

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Compounds related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1luminol4410.0SOD1, CCL11
2biliverdin44 2411.0HMOX1, BLVRA
3ptio449.9SOD1, HMOX1
43-nitrotyrosine449.9SOD1, HMOX1
5deta nonoate449.8HIF1A, HMOX1
6psgag449.8ELANE, CD36
7trolox449.8SOD1, HMOX1, HIF1A
8s-nitroso-n-acetylpenicillamine449.7HMOX1, HIF1A, SOD1
9gsno449.7HMOX1, SOD1, HIF1A
10rotenone449.7HMOX1, HIF1A, SOD1
11manganese superoxide449.7HMOX1, HIF1A, SOD1
1215-deoxy-delta-12,14-prostaglandin j2449.6CCL11, HMOX1, CD36
13pdtc449.6HMOX1, SOD1, HIF1A
14dihydrolipoic acid44 1110.5ELANE, SOD1
15nitroglycerin44 1110.5HIF1A, SOD1, ELANE
16deferoxamine44 1110.5HIF1A, HMOX1, FTMT, SOD1
17endotoxin449.5FTMT, CCL11, LBP, ELANE
18alpha lipoic acid449.5HMOX1, SOD1, SERPINA1
19peroxynitrite449.4SERPINA1, SOD1, CCL11
20rottlerin449.4CD36, ELANE, HMOX1
21n acetylcysteine449.4HMOX1, CCL11, SOD1, HIF1A
22hocl449.4SERPINA1, SOD1, ELANE
23actinomycin d449.3LBP, HIF1A, CCL11, HMOX1
24sb 20358044 6110.3CD36, HIF1A, HMOX1, CCL11
25sodium nitroprusside449.3SOD1, HIF1A, ELANE, HMOX1
26resveratrol44 61 24 1112.2HIF1A, SOD1, HMOX1
27egcg449.2ELANE, HIF1A, SOD1, HMOX1
28ly294002449.2CD36, HMOX1, CCL11, HIF1A
29adriamycin449.2SOD1, CD36, HIF1A
30alpha tocopherol449.1SOD1, HMOX1, CD36, ELANE
31cyclosporin a44 28 6111.0CCL11, HIF1A, HMOX1, ELANE
32desmosine449.0FBN1, SERPINA1, ELANE
33dexamethasone44 50 28 1111.9LBP, HIF1A, CCL11, HMOX1, CD36
34iron44 249.9HIF1A, SERPINA1, SOD1, FTMT, HMOX1
35nadph44 249.9HMOX1, SOD1, SERPINA1, HIF1A, BLVRA
36pge2448.8HMOX1, HIF1A, ELANE, CD36, CCL11
37vegf448.7CCL11, HIF1A, FBLN5, CD36, HMOX1
38hyaluronic acid44 249.7ELANE, CCL11, CD36, FBN1
39superoxide44 249.6SOD1, HIF1A, CCL11, LBP, HMOX1, ELANE
40lactate448.5ELANE, SOD1, HIF1A, HMOX1
41nitric oxide44 24 1110.5SOD1, HMOX1, CCL11, LBP, HIF1A, SERPINA1
42alanine448.3LBP, FBN1, HIF1A, SOD1, HMOX1, CCL11
43h2o2448.1SOD1, ELANE, CD36, SERPINA1, HMOX1, HIF1A
44retinoic acid44 249.0CCL11, HIF1A, ELANE, FBN1, CD36, HMOX1
45ascorbic acid44 248.8HMOX1, SOD1, SERPINA1, HIF1A, FBN1, CD36
46heparin44 28 24 1110.8SERPINA1, FBN1, LBP, CCL11, CD36, ELANE
47estrogen447.7SERPINA1, HIF1A, HMOX1, ELANE, CD36, FBN1
48serine447.4SERPINA1, FBN1, CD36, ELANE, LBP, HIF1A
49cysteine447.3ELANE, FBN1, SERPINA1, CD36, HMOX1, SOD1
50oxygen44 247.7BLVRA, LBP, FBN1, HIF1A, SERPINA1, SOD1

GO Terms for genes affiliated with Spontaneous Pneumothorax

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Cellular components related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.7SOD1, FBLN5, FBN1
2extracellular vesicular exosomeGO:0700628.3ELANE, SOD1, SERPINA1, BLVRA, LBP
3proteinaceous extracellular matrixGO:0055788.3FBN1, FBLN5, SERPINA1
4extracellular spaceGO:0056157.3HMOX1, LBP, FBN1, FBLN5, SERPINA1, SOD1
5extracellular regionGO:0055767.0LBP, FBN1, FBLN5, SERPINA1, SOD1, ELANE

Biological processes related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1heme catabolic processGO:04216710.2HMOX1, BLVRA
2regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.1HMOX1, HIF1A
3porphyrin-containing compound metabolic processGO:00677810.0HMOX1, BLVRA
4negative regulation of TOR signalingGO:03200710.0FLCN, HIF1A
5positive regulation of chemokine productionGO:03272210.0HIF1A, LBP
6cellular response to lipoteichoic acidGO:0712239.9CD36, LBP
7muscle cell cellular homeostasisGO:0467169.9HIF1A, SOD1
8low-density lipoprotein particle clearanceGO:0343839.9CD36, HMOX1
9regulation of removal of superoxide radicalsGO:20001219.8FBLN5, CD36
10positive regulation of angiogenesisGO:0457669.7HIF1A, CCL11, HMOX1
11defense response to Gram-positive bacteriumGO:0508309.7CD36, LBP
12positive regulation of tumor necrosis factor productionGO:0327609.7CD36, LBP
13negative regulation of neuron apoptotic processGO:0435249.6HIF1A, SOD1, HMOX1
14positive regulation of smooth muscle cell proliferationGO:0486619.6HMOX1, ELANE
15acute-phase responseGO:0069539.5LBP, SERPINA1
16positive regulation of interleukin-6 productionGO:0327559.5CD36, LBP
17negative regulation of growth of symbiont in hostGO:0441309.5CD36, ELANE, LBP
18cellular iron ion homeostasisGO:0068799.4HMOX1, FTMT, SOD1, HIF1A
19response to hydrogen peroxideGO:0425429.4HMOX1, SOD1
20response to lipopolysaccharideGO:0324969.3LBP, SERPINA1, ELANE
21platelet degranulationGO:0025769.2SERPINA1, SOD1, CD36
22platelet activationGO:0301689.1SERPINA1, SOD1, CD36

Molecular functions related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4CCL11, ELANE, FLCN, SOD1, SERPINA1, HIF1A

Products for genes affiliated with Spontaneous Pneumothorax

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Sources for Spontaneous Pneumothorax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet