MCID: SPN183
MIFTS: 31

Spontaneous Pneumothorax malady

Summaries for Spontaneous Pneumothorax

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MalaCards: Spontaneous Pneumothorax is related to pneumothorax and tuberculosis. An important gene associated with Spontaneous Pneumothorax is FLCN (folliculin), and among its related pathways are Platelet degranulation and Heme Biosynthesis. The compounds pge2 and nadph have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Spontaneous Pneumothorax

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20GeneTests, 44Novoseek, 60UMLS
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Aliases & Descriptions:

spontaneous pneumothorax 20 44 60


Related Diseases for Spontaneous Pneumothorax

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17GeneCards, 18GeneDecks
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Diseases in the Primary Spontaneous Pneumothorax family:

Spontaneous Pneumothorax Familial Type spontaneous pneumothorax

Diseases related to Spontaneous Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1pneumothorax32.1FLCN
2tuberculosis30.5SERPINA1
3pneumonia30.5CCL11, LBP, HMOX1, SERPINA1, ELANE
4marfan syndrome30.2CD36, FBN1
5myocardial infarction30.2HIF1A, CCL11, LBP
6asthma30.2SERPINA1, ELANE, CCL11, LBP
7cystic fibrosis30.2HMOX1, ELANE, LBP, SERPINA1
8acute myocardial infarction30.0SERPINA1
9sarcoidosis30.0CCL11
10pulmonary eosinophilia30.0CCL11
11endometriosis30.0CCL11
12leukemia30.0CCL11, HMOX1
13pulmonary emphysema30.0HMOX1, SERPINA1, ELANE
14primary spontaneous pneumothorax10.6
15pulmonary edema10.5
16lymphangioleiomyomatosis10.5
17silicosis10.4
18histiocytosis10.4
19langerhans-cell histiocytosis10.4
20lung cancer10.3
21bronchiolitis10.2
22spontaneous tension pneumothorax10.2
23ankylosing spondylitis10.2
24wegener's granulomatosis10.2
25birt-hogg-dube syndrome10.2
26miliary tuberculosis10.2
27osteosarcoma10.2
28sarcoma10.2
29spondylitis10.2
30mitral valve prolapse10.2
31bronchiolitis obliterans10.2
32blastoma10.2
33tuberous sclerosis10.2
34pleuropulmonary blastoma10.2
35alpha 1-antitrypsin deficiency10.2
36congenital diaphragmatic hernia10.2
37horner's syndrome10.2
38adenocarcinoma10.2
39aspergillosis10.2
40malignant mesothelioma10.2
41malignant pleural mesothelioma10.2
42pulmonary embolism10.2
43spontaneous pneumothorax familial type10.2
44burns10.0
45atrioventricular block10.0
46allergic bronchopulmonary aspergillosis10.0
47neurofibromatosis10.0
48bronchiolitis obliterans organizing pneumonia10.0
49severe acute respiratory syndrome10.0
50hemopneumothorax10.0

Graphical network of the top 20 diseases related to Spontaneous Pneumothorax:



Diseases related to spontaneous pneumothorax

Clinical Features for Spontaneous Pneumothorax

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Drugs & Therapeutics for Spontaneous Pneumothorax

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spontaneous Pneumothorax

Drug clinical trials:

Search ClinicalTrials for Spontaneous Pneumothorax

Search NIH Clinical Center for Spontaneous Pneumothorax

Search CenterWatch for Spontaneous Pneumothorax

Genetic Tests for Spontaneous Pneumothorax

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20GeneTests
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Genetic tests related to Spontaneous Pneumothorax:

id Genetic test Affiliating Genes
1 Spontaneous Pneumothorax20 FLCN

Anatomical Context for Spontaneous Pneumothorax

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Animal Models for Spontaneous Pneumothorax or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spontaneous Pneumothorax:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.1FLCN, HIF1A, CD36, HMOX1, FBN1
2MP:00053707.9SOD1, HIF1A, CD36, HMOX1, LBP
3MP:00053697.4FBN1, FBLN5, HIF1A, CD36, HMOX1, SOD1
4MP:00053977.3CD36, HIF1A, FLCN, FBN1, HMOX1, SOD1
5MP:00053857.1SOD1, FBLN5, FLCN, HIF1A, CD36, HMOX1
6MP:00053877.0FBN1, SOD1, LBP, FLCN, HIF1A, CD36
7MP:00053766.6LBP, FBN1, FBLN5, FLCN, HIF1A, CD36

Publications for Spontaneous Pneumothorax

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Genetic Variations for Spontaneous Pneumothorax

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Expression for genes affiliated with Spontaneous Pneumothorax

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spontaneous Pneumothorax

Search GEO for disease gene expression data for Spontaneous Pneumothorax.

Pathways for genes affiliated with Spontaneous Pneumothorax

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.5SERPINA1, CD36, SOD1
2
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9.1HMOX1, BLVRA
3
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9.1HMOX1, BLVRA

Compounds for genes affiliated with Spontaneous Pneumothorax

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pge24410.6CCL11
2nadph44 2411.4BLVRA
3luminol4410.3SOD1, CCL11
4alpha tocopherol4410.2ELANE, CD36
5psgag4410.1ELANE, CD36
6endotoxin4410.1FTMT, LBP
7rotenone4410.0HMOX1
8dihydrolipoic acid44 1110.9ELANE, SOD1
9hocl449.9SOD1, SERPINA1, ELANE
10onoo449.9SOD1, SERPINA1
11peroxynitrite449.9CCL11, SOD1, SERPINA1
12desmosine449.8FBN1, SERPINA1, ELANE
13(4-aminophenyl)mercuric acetate449.8ELANE
14ulinastatin449.8ELANE, SOD1
15tannins449.8ELANE, CD36
16nitroglycerin44 1110.7ELANE, HIF1A, SOD1
17dexamethasone44 49 28 1112.7CCL11, LBP, HIF1A
18ptio449.6HMOX1, SOD1
19serine449.6LBP, FBN1, BLVRA
203-nitrotyrosine449.6HMOX1, SOD1
21hyaluronic acid44 2410.5CCL11, FBN1, CD36, ELANE
22superoxide44 2410.5LBP, HMOX1, ELANE
23alpha lipoic acid449.4SOD1, HMOX1, SERPINA1
24biliverdin44 2410.4HMOX1, BLVRA
2515-deoxy-delta-12,14-prostaglandin j2449.3HMOX1, CD36, CCL11
26deta nonoate449.3HMOX1, HIF1A
27rottlerin449.3CD36, HMOX1, ELANE
28trolox449.3HMOX1, HIF1A, SOD1
29s-nitroso-n-acetylpenicillamine449.2SOD1, HIF1A, HMOX1
30gsno449.2SOD1, HIF1A, HMOX1
31manganese superoxide449.2SOD1, HIF1A, HMOX1
32pdtc449.1HMOX1, HIF1A, SOD1
33heparin44 28 11 2411.9CCL11, LBP, FBN1, CD36, SERPINA1, ELANE
34sodium nitroprusside448.9SOD1, HIF1A, HMOX1, ELANE
35egcg448.9SOD1, HIF1A, HMOX1, ELANE
36n acetylcysteine448.9CCL11, SOD1, HIF1A, HMOX1
37deferoxamine44 119.8HMOX1, FTMT, HIF1A, SOD1
38sb 20358044 599.8CCL11, HIF1A, CD36, HMOX1
39iron44 249.8HIF1A, FTMT, HMOX1, SERPINA1
40resveratrol44 59 11 2411.7HMOX1, HIF1A, SOD1
41actinomycin d448.7CCL11, LBP, HIF1A, HMOX1
42ly294002448.7HMOX1, CD36, HIF1A, CCL11
43nitric oxide44 11 2410.4CCL11, SOD1, LBP, HIF1A, HMOX1, SERPINA1
44alanine448.3CCL11, SOD1, LBP, FBN1, HIF1A, HMOX1
45h2o2448.2SOD1, HIF1A, CD36, HMOX1, SERPINA1, ELANE
46ascorbic acid44 249.2SOD1, FBN1, HIF1A, CD36, HMOX1, SERPINA1
47retinoic acid44 249.1ELANE, HMOX1, CD36, HIF1A, FBN1, CCL11
48vegf448.1CCL11, FBLN5, HIF1A, CD36, HMOX1
49cysteine447.8SOD1, FBN1, HIF1A, CD36, HMOX1, SERPINA1
50oxygen44 248.5ELANE, CCL11, LBP, FBN1, BLVRA, FTMT

GO Terms for genes affiliated with Spontaneous Pneumothorax

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16Gene Ontology
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Cellular components related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1FBLN5, FBN1, SOD1
2extracellular regionGO:0055767.6CCL11, SOD1, LBP, FBN1, FBLN5, SERPINA1
3extracellular spaceGO:0056157.3SERPINA1, CCL11, SOD1, LBP, FBN1, FBLN5

Biological processes related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.0CD36, LBP
2negative regulation of growth of symbiont in hostGO:0441309.8LBP, CD36, ELANE
3regulation of removal of superoxide radicalsGO:20001219.7CD36, FBLN5
4negative regulation of TOR signaling cascadeGO:0320079.7HIF1A, FLCN
5platelet degranulationGO:0025769.7SERPINA1, CD36, SOD1
6positive regulation of chemokine productionGO:0327229.7HIF1A, LBP
7response to lipopolysaccharideGO:0324969.6LBP, SERPINA1, ELANE
8muscle cell cellular homeostasisGO:0467169.6HIF1A, SOD1
9low-density lipoprotein particle clearanceGO:0343839.5CD36, HMOX1
10regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:0436199.4HIF1A, HMOX1
11heme catabolic processGO:0421679.4HMOX1, BLVRA
12positive regulation of angiogenesisGO:0457669.0HMOX1, HIF1A, CCL11
13negative regulation of neuron apoptotic processGO:0435248.9HMOX1, HIF1A, SOD1
14porphyrin-containing compound metabolic processGO:0067788.8HMOX1, BLVRA
15cellular iron ion homeostasisGO:0068798.7HMOX1, FTMT, HIF1A, SOD1

Products for genes affiliated with Spontaneous Pneumothorax

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Sources for Spontaneous Pneumothorax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet