MCID: SPN183
MIFTS: 31

Spontaneous Pneumothorax malady

Summaries for Spontaneous Pneumothorax

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MalaCards: Spontaneous Pneumothorax is related to pneumothorax and tuberculosis. An important gene associated with Spontaneous Pneumothorax is FLCN (folliculin), and among its related pathways are Platelet degranulation and Heme Biosynthesis. The compounds pge2 and nadph have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Spontaneous Pneumothorax

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20GeneTests, 44Novoseek, 60UMLS
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Aliases & Descriptions:

spontaneous pneumothorax 20 44 60


Related Diseases for Spontaneous Pneumothorax

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17GeneCards, 18GeneDecks
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Diseases in the Primary Spontaneous Pneumothorax family:

Spontaneous Pneumothorax Familial Type spontaneous pneumothorax

Diseases related to Spontaneous Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1pneumothorax32.1FLCN
2tuberculosis30.5SERPINA1
3pneumonia30.5CCL11, LBP, HMOX1, SERPINA1, ELANE
4marfan syndrome30.2CD36, FBN1
5myocardial infarction30.2HIF1A, CCL11, LBP
6asthma30.2SERPINA1, ELANE, CCL11, LBP
7cystic fibrosis30.2HMOX1, ELANE, LBP, SERPINA1
8acute myocardial infarction30.0SERPINA1
9sarcoidosis30.0CCL11
10pulmonary eosinophilia30.0CCL11
11endometriosis30.0CCL11
12leukemia30.0CCL11, HMOX1
13pulmonary emphysema30.0HMOX1, SERPINA1, ELANE
14primary spontaneous pneumothorax10.6
15pulmonary edema10.5
16lymphangioleiomyomatosis10.5
17silicosis10.4
18histiocytosis10.4
19langerhans-cell histiocytosis10.4
20lung cancer10.3
21bronchiolitis10.2
22spontaneous tension pneumothorax10.2
23ankylosing spondylitis10.2
24wegener's granulomatosis10.2
25birt-hogg-dube syndrome10.2
26miliary tuberculosis10.2
27osteosarcoma10.2
28sarcoma10.2
29spondylitis10.2
30mitral valve prolapse10.2
31bronchiolitis obliterans10.2
32blastoma10.2
33tuberous sclerosis10.2
34pleuropulmonary blastoma10.2
35alpha 1-antitrypsin deficiency10.2
36congenital diaphragmatic hernia10.2
37horner's syndrome10.2
38adenocarcinoma10.2
39aspergillosis10.2
40malignant mesothelioma10.2
41malignant pleural mesothelioma10.2
42pulmonary embolism10.2
43spontaneous pneumothorax familial type10.2
44burns10.0
45atrioventricular block10.0
46allergic bronchopulmonary aspergillosis10.0
47neurofibromatosis10.0
48bronchiolitis obliterans organizing pneumonia10.0
49severe acute respiratory syndrome10.0
50hemopneumothorax10.0

Graphical network of the top 20 diseases related to Spontaneous Pneumothorax:



Diseases related to spontaneous pneumothorax

Clinical Features for Spontaneous Pneumothorax

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Drugs & Therapeutics for Spontaneous Pneumothorax

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spontaneous Pneumothorax

Drug clinical trials:

Search ClinicalTrials for Spontaneous Pneumothorax

Search NIH Clinical Center for Spontaneous Pneumothorax

Search CenterWatch for Spontaneous Pneumothorax

Genetic Tests for Spontaneous Pneumothorax

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20GeneTests
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Genetic tests related to Spontaneous Pneumothorax:

id Genetic test Affiliating Genes
1 Spontaneous Pneumothorax20 FLCN

Anatomical Context for Spontaneous Pneumothorax

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Animal Models for Spontaneous Pneumothorax or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spontaneous Pneumothorax:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.1HMOX1, CD36, HIF1A, FLCN, FBN1
2MP:00053707.9SOD1, LBP, HIF1A, CD36, HMOX1
3MP:00053697.4SOD1, FBN1, FBLN5, HIF1A, CD36, HMOX1
4MP:00053977.3CCL11, SOD1, FBN1, FLCN, HIF1A, CD36
5MP:00053857.1SOD1, FBN1, FBLN5, FLCN, HIF1A, CD36
6MP:00053877.0ELANE, CCL11, SOD1, LBP, FBN1, FLCN
7MP:00053766.6SOD1, LBP, FBN1, FBLN5, FLCN, HIF1A

Publications for Spontaneous Pneumothorax

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Genetic Variations for Spontaneous Pneumothorax

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Expression for genes affiliated with Spontaneous Pneumothorax

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spontaneous Pneumothorax

Search GEO for disease gene expression data for Spontaneous Pneumothorax.

Pathways for genes affiliated with Spontaneous Pneumothorax

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.5SERPINA1, CD36, SOD1
2
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9.1HMOX1, BLVRA
3
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9.1HMOX1, BLVRA

Compounds for genes affiliated with Spontaneous Pneumothorax

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pge24410.6CCL11
2nadph44 2411.4BLVRA
3luminol4410.3CCL11, SOD1
4alpha tocopherol4410.2ELANE, CD36
5psgag4410.1ELANE, CD36
6endotoxin4410.1LBP, FTMT
7(4-aminophenyl)mercuric acetate4410.1ELANE
8rotenone4410.0HMOX1
9dihydrolipoic acid44 1110.9SOD1, ELANE
10hocl449.9SERPINA1, ELANE, SOD1
11onoo449.9SOD1, SERPINA1
12peroxynitrite449.9CCL11, SOD1, SERPINA1
13desmosine449.8SERPINA1, ELANE, FBN1
14tannins449.8ELANE, CD36
15nitroglycerin44 1110.7SOD1, ELANE, HIF1A
16dexamethasone44 49 28 1112.7CCL11, LBP, HIF1A
17ptio449.6SOD1, HMOX1
18serine449.6LBP, BLVRA, FBN1
193-nitrotyrosine449.6SOD1, HMOX1
20ulinastatin449.5ELANE, SOD1
21hyaluronic acid44 2410.5ELANE, CD36, FBN1, CCL11
22superoxide44 2410.5HMOX1, ELANE, LBP
23alpha lipoic acid449.4HMOX1, SOD1, SERPINA1
24biliverdin44 2410.4HMOX1, BLVRA
2515-deoxy-delta-12,14-prostaglandin j2449.3CD36, HMOX1, CCL11
26deta nonoate449.3HMOX1, HIF1A
27rottlerin449.3ELANE, CD36, HMOX1
28trolox449.3HIF1A, SOD1, HMOX1
29gsno449.2HMOX1, HIF1A, SOD1
30s-nitroso-n-acetylpenicillamine449.2SOD1, HMOX1, HIF1A
31manganese superoxide449.2SOD1, HIF1A, HMOX1
32pdtc449.1SOD1, HMOX1, HIF1A
33heparin44 28 11 2411.9LBP, CCL11, FBN1, SERPINA1, ELANE, CD36
34sodium nitroprusside448.9HMOX1, HIF1A, SOD1, ELANE
35egcg448.9ELANE, HIF1A, HMOX1, SOD1
36n acetylcysteine448.9HIF1A, SOD1, HMOX1, CCL11
37deferoxamine44 119.8SOD1, FTMT, HMOX1, HIF1A
38sb 20358044 599.8CCL11, HIF1A, CD36, HMOX1
39iron44 249.8HIF1A, SERPINA1, HMOX1, FTMT
40resveratrol44 59 11 2411.7SOD1, HMOX1, HIF1A
41actinomycin d448.7LBP, HIF1A, CCL11, HMOX1
42ly294002448.7CD36, HIF1A, HMOX1, CCL11
43nitric oxide44 11 2410.4CCL11, HMOX1, SOD1, SERPINA1, HIF1A, LBP
44alanine448.3FBN1, HMOX1, HIF1A, LBP, SOD1, CCL11
45h2o2448.2SOD1, HIF1A, CD36, HMOX1, ELANE, SERPINA1
46ascorbic acid44 249.2HMOX1, CD36, SERPINA1, SOD1, HIF1A, FBN1
47retinoic acid44 249.1CCL11, HIF1A, FBN1, HMOX1, ELANE, CD36
48vegf448.1HMOX1, HIF1A, FBLN5, CD36, CCL11
49cysteine447.8SOD1, HIF1A, ELANE, SERPINA1, CD36, HMOX1
50oxygen44 248.5LBP, SERPINA1, BLVRA, ELANE, HMOX1, FTMT

GO Terms for genes affiliated with Spontaneous Pneumothorax

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16Gene Ontology
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Cellular components related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1FBLN5, FBN1, SOD1
2extracellular regionGO:0055767.6CCL11, SOD1, LBP, FBN1, FBLN5, SERPINA1
3extracellular spaceGO:0056157.3SERPINA1, CCL11, SOD1, LBP, FBN1, FBLN5

Biological processes related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.0CD36, LBP
2negative regulation of growth of symbiont in hostGO:0441309.8LBP, CD36, ELANE
3regulation of removal of superoxide radicalsGO:20001219.7CD36, FBLN5
4negative regulation of TOR signaling cascadeGO:0320079.7HIF1A, FLCN
5platelet degranulationGO:0025769.7SERPINA1, CD36, SOD1
6positive regulation of chemokine productionGO:0327229.7HIF1A, LBP
7response to lipopolysaccharideGO:0324969.6LBP, SERPINA1, ELANE
8muscle cell cellular homeostasisGO:0467169.6HIF1A, SOD1
9low-density lipoprotein particle clearanceGO:0343839.5CD36, HMOX1
10regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:0436199.4HIF1A, HMOX1
11heme catabolic processGO:0421679.4HMOX1, BLVRA
12positive regulation of angiogenesisGO:0457669.0HMOX1, HIF1A, CCL11
13negative regulation of neuron apoptotic processGO:0435248.9HMOX1, HIF1A, SOD1
14porphyrin-containing compound metabolic processGO:0067788.8HMOX1, BLVRA
15cellular iron ion homeostasisGO:0068798.7HMOX1, FTMT, HIF1A, SOD1

Products for genes affiliated with Spontaneous Pneumothorax

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Sources for Spontaneous Pneumothorax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet