MCID: SPN183
MIFTS: 52

Spontaneous Pneumothorax malady

Genetic diseases, Rare diseases, Respiratory diseases categories

Summaries for Spontaneous Pneumothorax

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MalaCards based summary: Spontaneous Pneumothorax is related to pneumothorax and pneumonia. An important gene associated with Spontaneous Pneumothorax is FLCN (folliculin), and among its related pathways are IL-10 Pathway and Oxidative Stress. The compounds luminol and biliverdin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone marrow, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Spontaneous Pneumothorax

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Sources:
22GeneTests, 45Novoseek, 62UMLS
See all sources

Spontaneous Pneumothorax, Aliases & Descriptions:

Name: Spontaneous Pneumothorax 22 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


Related Diseases for Spontaneous Pneumothorax

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Diseases in the Spontaneous Pneumothorax family:

Pneumothorax, Primary Spontaneous Spontaneous Pneumothorax Familial Type

Diseases related to Spontaneous Pneumothorax via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1pneumothorax32.3FLCN
2pneumonia30.6HMOX1, CCL11, ELANE, SERPINA1, LBP
3bronchiolitis30.5CCL11
4myocardial infarction30.3CCL11, HIF1A, LBP
5marfan syndrome30.3FBN1, CD36
6asthma30.3LBP, SERPINA1, ELANE, CCL11
7cystic fibrosis30.3HMOX1, ELANE, SERPINA1, LBP
8acute respiratory distress syndrome30.1ELANE, LBP
9respiratory failure30.1ELANE, CCL11
10pulmonary emphysema30.1SERPINA1, ELANE, HMOX1
11wegener granulomatosis30.1SERPINA1, ELANE
12pneumothorax, primary spontaneous10.6
13pulmonary edema10.6
14lymphangioleiomyomatosis10.5
15tuberculosis10.4
16silicosis10.4
17langerhans-cell histiocytosis10.4
18histiocytosis10.4
19birt-hogg-dube syndrome10.4
20lung cancer10.4
21miliary tuberculosis10.4
22spontaneous pneumothorax familial type10.4
23malignant pleural mesothelioma10.3
24sarcoma10.3
25spondylitis10.3
26catamenial pneumothorax10.3
27mesothelioma10.3
28pulmonary function10.2
29aspergillosis10.2
30pleuropulmonary blastoma10.2
31bronchiolitis obliterans10.2
32blastoma10.2
33horner's syndrome10.2
34tuberous sclerosis10.2
35congenital diaphragmatic hernia10.2
36adenocarcinoma10.2
37endometriosis10.2
38pulmonary embolism10.2
39pulmonary alveolar microlithiasis10.1
40ehlers-danlos syndrome, type iv10.1
41acute leukemia10.1
42acute myocardial infarction10.1
43burns10.1
44hematopoietic stem cell transplantation10.1
45leukemia10.1
46lymphomatoid granulomatosis10.1
47mantle cell lymphoma10.1
48diffuse scleroderma10.1
49hemopneumothorax10.1
50severe acute respiratory syndrome10.1

Graphical network of the top 20 diseases related to Spontaneous Pneumothorax:



Diseases related to spontaneous pneumothorax

Symptoms for Spontaneous Pneumothorax

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Drugs & Therapeutics for Spontaneous Pneumothorax

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Drug clinical trials:

Search ClinicalTrials for Spontaneous Pneumothorax

Search NIH Clinical Center for Spontaneous Pneumothorax

Genetic Tests for Spontaneous Pneumothorax

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Genetic tests related to Spontaneous Pneumothorax:

id Genetic test Affiliating Genes
1 Spontaneous Pneumothorax22 FLCN

Anatomical Context for Spontaneous Pneumothorax

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MalaCards organs/tissues related to Spontaneous Pneumothorax:

33
Lung, Testes, Bone marrow, Bone, Spleen, Colon, Kidney, Liver, Thyroid, Skin

Animal Models for Spontaneous Pneumothorax or affiliated genes

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MGI Mouse Phenotypes related to Spontaneous Pneumothorax:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6LBP, HIF1A, SOD1, HMOX1, CD36
2MP:00053678.2FBN1, HIF1A, FLCN, HMOX1, CD36
3MP:00053888.1HMOX1, CCL11, HIF1A, FBLN5, FBN1
4MP:00053797.7FBN1, HIF1A, SOD1, HMOX1, CD36
5MP:00053697.7FBN1, FBLN5, HIF1A, SOD1, HMOX1, CD36
6MP:00053857.5FBN1, FBLN5, HIF1A, SOD1, FLCN, HMOX1
7MP:00053847.4FBN1, FBLN5, HIF1A, SOD1, FLCN, HMOX1
8MP:00107687.2CD36, HMOX1, ELANE, FLCN, SOD1, HIF1A
9MP:00053976.8CD36, LBP, FBN1, HIF1A, SOD1, FLCN
10MP:00053876.8LBP, FBN1, HIF1A, SOD1, FLCN, ELANE
11MP:00053766.7LBP, FBN1, FBLN5, HIF1A, SOD1, FLCN

Publications for Spontaneous Pneumothorax

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Articles related to Spontaneous Pneumothorax:

(show top 50)    (show all 655)
idTitleAuthorsYear
1
Malignant pleural mesothelioma presenting as a spontaneous pneumothorax. (25802741)
2015
2
Assessment of spontaneous pneumothorax in adults in a tertiary care hospital. (25814797)
2015
3
Video-assisted thoracic surgery versus pleural drainage in the management of the first episode of primary spontaneous pneumothorax. (25769881)
2015
4
Detection of blebs and bullae in patients with primary spontaneous pneumothorax by multi-detector CT reconstruction using different slice thicknesses. (25196152)
2014
5
Spontaneous pneumothorax in ataxia telangectasia. (25297371)
2014
6
Video-assisted thoracoscopic surgery for postoperative recurrent primary spontaneous pneumothorax. (24455176)
2014
7
Birt-Hogg-DubAc syndrome in a patient presenting with familial spontaneous pneumothorax. (24996715)
2014
8
Vascular-penetration defect detected in parietal pleura of primary spontaneous pneumothorax. (25015539)
2014
9
Anesthesia under cardiopulmonary bypass for video assisted thoracoscopic wedge resection in patient with spontaneous pneumothorax and contralateral post-tuberculosis destroyed lung. (24024004)
2013
10
Sensitivity, positive predictive value, and interobserver variability of computed tomography in the diagnosis of bullae associated with spontaneous pneumothorax in dogs: 19 cases (2003-2012). (23822082)
2013
11
Prevalence, clinical manifestations and mortality rate in patients with spontaneous pneumothorax in Thammasat University Hospital. (24350409)
2013
12
Spontaneous pneumothorax with persistent air leakage and invasive procedures. (24088750)
2013
13
The Effect of Thoracoscopic Pleurodesis in Primary Spontaneous Pneumothorax: Apical Parietal Pleurectomy versus Pleural Abrasion. (23130305)
2012
14
Spontaneous pneumothorax and ozone levels: is there a relation? (22958437)
2011
15
Recurrent spontaneous pneumothorax in a patient with Birt-Hogg-DubAc syndrome. (20692178)
2011
16
An unusual cause of spontaneous pneumothorax: the Mounier-Kuhn syndrome. (21736094)
2011
17
A rare cause of recurrent spontaneous pneumothorax. (21525091)
2011
18
Efficacy of blood-patch pleurodesis for secondary spontaneous pneumothorax in interstitial lung disease. (21628929)
2011
19
Erlotinib treatment for persistent spontaneous pneumothorax in non-small cell lung cancer: a case report. (22166539)
2010
20
Chemotherapy-related delayed bilateral spontaneous pneumothorax and lung fibrosis: methotrexate or cyclophosphamide, or both? (20931743)
2010
21
Surgery for secondary spontaneous pneumothorax. (20453650)
2010
22
Radiological predictors of recurrent primary spontaneous pneumothorax following non-surgical management. (20673650)
2010
23
Percutaneous aspiration versus tube drainage for spontaneous pneumothorax: systematic review and meta-analysis. (20060735)
2010
24
Decision making in the management of secondary spontaneous pneumothorax in patients with severe emphysema. (19662966)
2009
25
Simultaneous bilateral spontaneous pneumothorax in metastatic testicular cancer. (19140040)
2009
26
Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia. (19385305)
2009
27
Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation. (19483054)
2009
28
A case of spontaneous pneumothorax presenting with high-degree atrioventricular block. (19729170)
2009
29
Video-assisted thoracoscopy for spontaneous pneumothorax after pneumonectomy. (18514025)
2009
30
Re-expansion pulmonary edema following treatment of spontaneous pneumothorax during oral surgery. (19462219)
2009
31
Anesthetic management of thoracotomy for spontaneous pneumothorax in a pregnant woman. (17693074)
2008
32
Thoracoscopic apico-posterior transmediastinal approach for bilateral spontaneous pneumothorax. (18187456)
2008
33
Should surgical pleurectomy for spontaneous pneumothorax be always thoracoscopic? (18407960)
2008
34
Does video-assisted thoracoscopic pleurectomy result in better outcomes than open pleurectomy for primary spontaneous pneumothorax? (18287119)
2008
35
Ipsilateral reexpansion pulmonary edema after drainage of a spontaneous pneumothorax: a case report. (17903268)
2007
36
Use of computed tomography for evaluation of lung lesions associated with spontaneous pneumothorax in dogs: 12 cases (1999-2002). (16506938)
2006
37
Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. (16376095)
2006
38
Aetiology and clinical profile of spontaneous pneumothorax in adults. (16970292)
2006
39
Thoracoscopic management of spontaneous pneumothorax during pregnancy. (16165137)
2005
40
Does a thoracic epidural confer any additional benefit following video-assisted thoracoscopic pleurectomy for primary spontaneous pneumothorax? (15784372)
2005
41
Physical fitness after apical resection for the treatment of primary spontaneous pneumothorax. (16261980)
2005
42
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. (15805188)
2005
43
Video-assisted thoracic surgery (VATS) for primary spontaneous pneumothorax: how I do it ? (16184724)
2005
44
Evaluating the treatment options for spontaneous pneumothorax. (15311535)
2004
45
Results of thoracoscopic pleural abrasion for primary spontaneous pneumothorax. (14752638)
2004
46
Video-assisted thoracoscopic management of recurrent primary spontaneous pneumothorax after prior talc pleurodesis: a feasible, safe and efficient treatment option. (15519177)
2004
47
Role of chest CT scan in determining etiology of primary spontaneous pneumothorax. (12866634)
2003
48
Diagnosis of pulmonary lymphangioleiomyomatosis by HMB45 in surgically treated spontaneous pneumothorax. (8620956)
1995
49
Value of computed tomography of the lung in the management of primary spontaneous pneumothorax. (2063968)
1991
50
Recurrent spontaneous pneumothorax in diffuse scleroderma. Report of a case. (5907810)
1966

Variations for Spontaneous Pneumothorax

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Expression for genes affiliated with Spontaneous Pneumothorax

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Search GEO for disease gene expression data for Spontaneous Pneumothorax.

Pathways for genes affiliated with Spontaneous Pneumothorax

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Pathways related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HMOX1, BLVRA
29.7HMOX1, SOD1
3
Show member pathways
tetrapyrrole biosynthesis38
heme degradation38
Heme Biosynthesis38
heme biosynthesis38
heme biosynthesis from uroporphyrinogen-III I38
9.6HMOX1, FTMT, BLVRA
4
Show member pathways
FOXA transcription factor networks38
9.4SOD1, SERPINA1
59.4CD36, ELANE
69.3SERPINA1, ELANE
7
Show member pathways
9.2FBLN5, FBN1
8
Show member pathways
8.9SERPINA1, SOD1, CD36
9
Show member pathways
8.7FBN1, FBLN5, ELANE

Compounds for genes affiliated with Spontaneous Pneumothorax

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Compounds related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1luminol4510.0SOD1, CCL11
2biliverdin45 2611.0HMOX1, BLVRA
3ptio459.9SOD1, HMOX1
43-nitrotyrosine459.9SOD1, HMOX1
5deta nonoate459.8HIF1A, HMOX1
6psgag459.8ELANE, CD36
7trolox459.8SOD1, HMOX1, HIF1A
8s-nitroso-n-acetylpenicillamine459.7HMOX1, HIF1A, SOD1
9gsno459.7HMOX1, SOD1, HIF1A
10rotenone459.7HMOX1, HIF1A, SOD1
11manganese superoxide459.7HMOX1, HIF1A, SOD1
1215-deoxy-delta-12,14-prostaglandin j2459.6CCL11, HMOX1, CD36
13pdtc459.6HMOX1, SOD1, HIF1A
14dihydrolipoic acid45 1310.5ELANE, SOD1
15nitroglycerin45 1310.5HIF1A, SOD1, ELANE
16deferoxamine45 1310.5HIF1A, HMOX1, FTMT, SOD1
17endotoxin459.5FTMT, CCL11, LBP, ELANE
18alpha lipoic acid459.5HMOX1, SOD1, SERPINA1
19peroxynitrite459.4SERPINA1, SOD1, CCL11
20rottlerin459.4CD36, ELANE, HMOX1
21n acetylcysteine459.4HMOX1, CCL11, SOD1, HIF1A
22hocl459.4SERPINA1, SOD1, ELANE
23actinomycin d459.3LBP, HIF1A, CCL11, HMOX1
24sb 20358045 6110.3CD36, HIF1A, HMOX1, CCL11
25sodium nitroprusside459.3SOD1, HIF1A, ELANE, HMOX1
26resveratrol45 61 26 1312.2HIF1A, SOD1, HMOX1
27egcg459.2ELANE, HIF1A, SOD1, HMOX1
28ly294002459.2CD36, HMOX1, CCL11, HIF1A
29adriamycin459.2SOD1, CD36, HIF1A
30alpha tocopherol459.1SOD1, HMOX1, CD36, ELANE
31cyclosporin a45 30 6111.0CCL11, HIF1A, HMOX1, ELANE
32desmosine459.0FBN1, SERPINA1, ELANE
33dexamethasone45 51 30 1311.9LBP, HIF1A, CCL11, HMOX1, CD36
34iron45 269.9HIF1A, SERPINA1, SOD1, FTMT, HMOX1
35nadph45 269.9HMOX1, SOD1, SERPINA1, HIF1A, BLVRA
36pge2458.8HMOX1, HIF1A, ELANE, CD36, CCL11
37vegf458.7CCL11, HIF1A, FBLN5, CD36, HMOX1
38hyaluronic acid45 269.7ELANE, CCL11, CD36, FBN1
39superoxide45 269.6SOD1, HIF1A, CCL11, LBP, HMOX1, ELANE
40lactate458.5ELANE, SOD1, HIF1A, HMOX1
41nitric oxide45 26 1310.5SOD1, HMOX1, CCL11, LBP, HIF1A, SERPINA1
42alanine458.3LBP, FBN1, HIF1A, SOD1, HMOX1, CCL11
43h2o2458.1SOD1, ELANE, CD36, SERPINA1, HMOX1, HIF1A
44retinoic acid45 269.0CCL11, HIF1A, ELANE, FBN1, CD36, HMOX1
45ascorbic acid45 268.8HMOX1, SOD1, SERPINA1, HIF1A, FBN1, CD36
46heparin45 30 26 1310.8SERPINA1, FBN1, LBP, CCL11, CD36, ELANE
47estrogen457.7SERPINA1, HIF1A, HMOX1, ELANE, CD36, FBN1
48serine457.4SERPINA1, FBN1, CD36, ELANE, LBP, HIF1A
49cysteine457.3ELANE, FBN1, SERPINA1, CD36, HMOX1, SOD1
50oxygen45 267.7BLVRA, LBP, FBN1, HIF1A, SERPINA1, SOD1

GO Terms for genes affiliated with Spontaneous Pneumothorax

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Cellular components related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.7SOD1, FBLN5, FBN1
2extracellular vesicular exosomeGO:00700628.3ELANE, SOD1, SERPINA1, BLVRA, LBP
3proteinaceous extracellular matrixGO:00055788.3FBN1, FBLN5, SERPINA1
4extracellular spaceGO:00056157.3HMOX1, LBP, FBN1, FBLN5, SERPINA1, SOD1
5extracellular regionGO:00055767.0LBP, FBN1, FBLN5, SERPINA1, SOD1, ELANE

Biological processes related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1heme catabolic processGO:004216710.2HMOX1, BLVRA
2regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:004361910.1HMOX1, HIF1A
3porphyrin-containing compound metabolic processGO:000677810.0HMOX1, BLVRA
4negative regulation of TOR signalingGO:003200710.0FLCN, HIF1A
5positive regulation of chemokine productionGO:003272210.0HIF1A, LBP
6cellular response to lipoteichoic acidGO:00712239.9CD36, LBP
7muscle cell cellular homeostasisGO:00467169.9HIF1A, SOD1
8low-density lipoprotein particle clearanceGO:00343839.9CD36, HMOX1
9regulation of removal of superoxide radicalsGO:020001219.8FBLN5, CD36
10positive regulation of angiogenesisGO:00457669.7HIF1A, CCL11, HMOX1
11defense response to Gram-positive bacteriumGO:00508309.7CD36, LBP
12positive regulation of tumor necrosis factor productionGO:00327609.7CD36, LBP
13negative regulation of neuron apoptotic processGO:00435249.6HIF1A, SOD1, HMOX1
14positive regulation of smooth muscle cell proliferationGO:00486619.6HMOX1, ELANE
15acute-phase responseGO:00069539.5LBP, SERPINA1
16positive regulation of interleukin-6 productionGO:00327559.5CD36, LBP
17negative regulation of growth of symbiont in hostGO:00441309.5CD36, ELANE, LBP
18cellular iron ion homeostasisGO:00068799.4HMOX1, FTMT, SOD1, HIF1A
19response to hydrogen peroxideGO:00425429.4HMOX1, SOD1
20response to lipopolysaccharideGO:00324969.3LBP, SERPINA1, ELANE
21platelet degranulationGO:00025769.2SERPINA1, SOD1, CD36
22platelet activationGO:00301689.1SERPINA1, SOD1, CD36

Molecular functions related to Spontaneous Pneumothorax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.4CCL11, ELANE, FLCN, SOD1, SERPINA1, HIF1A

Products for genes affiliated with Spontaneous Pneumothorax

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Sources for Spontaneous Pneumothorax

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet