MCID: SPN183
MIFTS: 45

Spontaneous Pneumothorax malady

Genetic diseases, Rare diseases, Respiratory diseases categories

Aliases & Classifications for Spontaneous Pneumothorax

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Sources:
20GeneTests, 43Novoseek, 60UMLS
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Spontaneous Pneumothorax, Aliases & Descriptions:

Name: Spontaneous Pneumothorax 20 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


Summaries for Spontaneous Pneumothorax

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MalaCards based summary: Spontaneous Pneumothorax is related to pneumothorax and bronchiolitis. An important gene associated with Spontaneous Pneumothorax is FLCN (folliculin), and among its related pathways are IL-10 Pathway and Oxidative Stress. The compounds luminol and biliverdin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone marrow, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Related Diseases for Spontaneous Pneumothorax

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Diseases in the Spontaneous Pneumothorax family:

Pneumothorax, Primary Spontaneous Spontaneous Pneumothorax Familial Type

Diseases related to Spontaneous Pneumothorax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1pneumothorax33.0FLCN
2bronchiolitis31.1CCL11
3myocardial infarction30.4CCL11, HIF1A, LBP
4marfan syndrome30.4FBN1, CD36
5acute respiratory distress syndrome30.4ELANE, LBP
6respiratory failure30.4ELANE, CCL11
7pneumonia30.3HMOX1, CCL11, ELANE, SERPINA1, LBP
8pulmonary emphysema30.1SERPINA1, ELANE, HMOX1
9asthma30.1LBP, SERPINA1, ELANE, CCL11
10cystic fibrosis30.1HMOX1, ELANE, SERPINA1, LBP
11wegener granulomatosis30.1SERPINA1, ELANE
12pneumothorax, primary spontaneous10.7
13pulmonary edema10.6
14lymphangioleiomyomatosis10.5
15tuberculosis10.4
16arthus reaction10.4ELANE
17silicosis10.4
18langerhans-cell histiocytosis10.4
19histiocytosis10.4
20spontaneous pneumothorax familial type10.4
21birt-hogg-dube syndrome10.4
22lung cancer10.4
23miliary tuberculosis10.4
24porphyria, acute intermittent10.3HMOX1, SOD1
25malignant pleural mesothelioma10.3
26sarcoma10.3
27spondylitis10.3
28catamenial pneumothorax10.3
29mesothelioma10.3
30vernal keratoconjunctivitis10.3CD36, CCL11
31pulmonary disease, chronic obstructive10.2HMOX1, SERPINA1
32malaria10.2CD36, HMOX1
33bronchopulmonary dysplasia10.2SOD1, ELANE
34pulmonary function10.2
35aspergillosis10.2
36pleuropulmonary blastoma10.2
37bronchiolitis obliterans10.2
38blastoma10.2
39horner's syndrome10.2
40tuberous sclerosis10.2
41congenital diaphragmatic hernia10.2
42adenocarcinoma10.2
43endometriosis10.2
44pulmonary embolism10.2
45arteriosclerosis10.2HMOX1, SOD1
46chronic ulcer of skin10.2ELANE, CD36
47spiradenoma10.2CCL11, SERPINA1
48dermatitis herpetiformis10.1CCL11, FBN1
49intracranial aneurysm10.1SERPINA1, ELANE
50emphysema due to aat deficiency10.1ELANE, SERPINA1

Graphical network of the top 20 diseases related to Spontaneous Pneumothorax:



Diseases related to spontaneous pneumothorax

Symptoms for Spontaneous Pneumothorax

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Drugs & Therapeutics for Spontaneous Pneumothorax

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Drug clinical trials:

Search ClinicalTrials for Spontaneous Pneumothorax

Search NIH Clinical Center for Spontaneous Pneumothorax

Genetic Tests for Spontaneous Pneumothorax

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Genetic tests related to Spontaneous Pneumothorax:

id Genetic test Affiliating Genes
1 Spontaneous Pneumothorax20 FLCN

Anatomical Context for Spontaneous Pneumothorax

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MalaCards organs/tissues related to Spontaneous Pneumothorax:

31
Lung, Testes, Bone marrow, Bone, Spleen, Colon, Kidney, Liver, Thyroid, Skin

Animal Models for Spontaneous Pneumothorax or affiliated genes

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MGI Mouse Phenotypes related to Spontaneous Pneumothorax:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6LBP, HIF1A, SOD1, HMOX1, CD36
2MP:00053678.2FBN1, HIF1A, FLCN, HMOX1, CD36
3MP:00053888.1HMOX1, CCL11, HIF1A, FBLN5, FBN1
4MP:00053797.7FBN1, HIF1A, SOD1, HMOX1, CD36
5MP:00053697.7FBN1, FBLN5, HIF1A, SOD1, HMOX1, CD36
6MP:00053857.5FBN1, FBLN5, HIF1A, SOD1, FLCN, HMOX1
7MP:00053847.4FBN1, FBLN5, HIF1A, SOD1, FLCN, HMOX1
8MP:00107687.2CD36, HMOX1, ELANE, FLCN, SOD1, HIF1A
9MP:00053976.8CD36, LBP, FBN1, HIF1A, SOD1, FLCN
10MP:00053876.8LBP, FBN1, HIF1A, SOD1, FLCN, ELANE
11MP:00053766.7LBP, FBN1, FBLN5, HIF1A, SOD1, FLCN

Publications for Spontaneous Pneumothorax

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Articles related to Spontaneous Pneumothorax:

(show top 50)    (show all 655)
idTitleAuthorsYear
1
Malignant pleural mesothelioma presenting as a spontaneous pneumothorax. (25802741)
2015
2
Assessment of spontaneous pneumothorax in adults in a tertiary care hospital. (25814797)
2015
3
Video-assisted thoracic surgery versus pleural drainage in the management of the first episode of primary spontaneous pneumothorax. (25769881)
2015
4
Detection of blebs and bullae in patients with primary spontaneous pneumothorax by multi-detector CT reconstruction using different slice thicknesses. (25196152)
2014
5
Spontaneous pneumothorax in ataxia telangectasia. (25297371)
2014
6
Video-assisted thoracoscopic surgery for postoperative recurrent primary spontaneous pneumothorax. (24455176)
2014
7
Birt-Hogg-DubAc syndrome in a patient presenting with familial spontaneous pneumothorax. (24996715)
2014
8
Vascular-penetration defect detected in parietal pleura of primary spontaneous pneumothorax. (25015539)
2014
9
Anesthesia under cardiopulmonary bypass for video assisted thoracoscopic wedge resection in patient with spontaneous pneumothorax and contralateral post-tuberculosis destroyed lung. (24024004)
2013
10
Sensitivity, positive predictive value, and interobserver variability of computed tomography in the diagnosis of bullae associated with spontaneous pneumothorax in dogs: 19 cases (2003-2012). (23822082)
2013
11
Prevalence, clinical manifestations and mortality rate in patients with spontaneous pneumothorax in Thammasat University Hospital. (24350409)
2013
12
Spontaneous pneumothorax with persistent air leakage and invasive procedures. (24088750)
2013
13
The Effect of Thoracoscopic Pleurodesis in Primary Spontaneous Pneumothorax: Apical Parietal Pleurectomy versus Pleural Abrasion. (23130305)
2012
14
Spontaneous pneumothorax and ozone levels: is there a relation? (22958437)
2011
15
Recurrent spontaneous pneumothorax in a patient with Birt-Hogg-DubAc syndrome. (20692178)
2011
16
An unusual cause of spontaneous pneumothorax: the Mounier-Kuhn syndrome. (21736094)
2011
17
A rare cause of recurrent spontaneous pneumothorax. (21525091)
2011
18
Efficacy of blood-patch pleurodesis for secondary spontaneous pneumothorax in interstitial lung disease. (21628929)
2011
19
Erlotinib treatment for persistent spontaneous pneumothorax in non-small cell lung cancer: a case report. (22166539)
2010
20
Chemotherapy-related delayed bilateral spontaneous pneumothorax and lung fibrosis: methotrexate or cyclophosphamide, or both? (20931743)
2010
21
Surgery for secondary spontaneous pneumothorax. (20453650)
2010
22
Radiological predictors of recurrent primary spontaneous pneumothorax following non-surgical management. (20673650)
2010
23
Percutaneous aspiration versus tube drainage for spontaneous pneumothorax: systematic review and meta-analysis. (20060735)
2010
24
Decision making in the management of secondary spontaneous pneumothorax in patients with severe emphysema. (19662966)
2009
25
Simultaneous bilateral spontaneous pneumothorax in metastatic testicular cancer. (19140040)
2009
26
Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia. (19385305)
2009
27
Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation. (19483054)
2009
28
A case of spontaneous pneumothorax presenting with high-degree atrioventricular block. (19729170)
2009
29
Video-assisted thoracoscopy for spontaneous pneumothorax after pneumonectomy. (18514025)
2009
30
Re-expansion pulmonary edema following treatment of spontaneous pneumothorax during oral surgery. (19462219)
2009
31
Anesthetic management of thoracotomy for spontaneous pneumothorax in a pregnant woman. (17693074)
2008
32
Thoracoscopic apico-posterior transmediastinal approach for bilateral spontaneous pneumothorax. (18187456)
2008
33
Should surgical pleurectomy for spontaneous pneumothorax be always thoracoscopic? (18407960)
2008
34
Does video-assisted thoracoscopic pleurectomy result in better outcomes than open pleurectomy for primary spontaneous pneumothorax? (18287119)
2008
35
Ipsilateral reexpansion pulmonary edema after drainage of a spontaneous pneumothorax: a case report. (17903268)
2007
36
Use of computed tomography for evaluation of lung lesions associated with spontaneous pneumothorax in dogs: 12 cases (1999-2002). (16506938)
2006
37
Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. (16376095)
2006
38
Aetiology and clinical profile of spontaneous pneumothorax in adults. (16970292)
2006
39
Thoracoscopic management of spontaneous pneumothorax during pregnancy. (16165137)
2005
40
Does a thoracic epidural confer any additional benefit following video-assisted thoracoscopic pleurectomy for primary spontaneous pneumothorax? (15784372)
2005
41
Physical fitness after apical resection for the treatment of primary spontaneous pneumothorax. (16261980)
2005
42
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. (15805188)
2005
43
Video-assisted thoracic surgery (VATS) for primary spontaneous pneumothorax: how I do it ? (16184724)
2005
44
Evaluating the treatment options for spontaneous pneumothorax. (15311535)
2004
45
Results of thoracoscopic pleural abrasion for primary spontaneous pneumothorax. (14752638)
2004
46
Video-assisted thoracoscopic management of recurrent primary spontaneous pneumothorax after prior talc pleurodesis: a feasible, safe and efficient treatment option. (15519177)
2004
47
Role of chest CT scan in determining etiology of primary spontaneous pneumothorax. (12866634)
2003
48
Diagnosis of pulmonary lymphangioleiomyomatosis by HMB45 in surgically treated spontaneous pneumothorax. (8620956)
1995
49
Value of computed tomography of the lung in the management of primary spontaneous pneumothorax. (2063968)
1991
50
Recurrent spontaneous pneumothorax in diffuse scleroderma. Report of a case. (5907810)
1966

Variations for Spontaneous Pneumothorax

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Expression for genes affiliated with Spontaneous Pneumothorax

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Search GEO for disease gene expression data for Spontaneous Pneumothorax.

Pathways for genes affiliated with Spontaneous Pneumothorax

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Pathways related to Spontaneous Pneumothorax according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HMOX1, BLVRA
29.7HMOX1, SOD1
3
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.6HMOX1, FTMT, BLVRA
4
Show member pathways
FOXA transcription factor networks36
9.4SOD1, SERPINA1
5
Show member pathways
9.2FBLN5, FBN1
6
Show member pathways
8.9SERPINA1, SOD1, CD36
7
Show member pathways
8.7FBN1, FBLN5, ELANE

Compounds for genes affiliated with Spontaneous Pneumothorax

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Compounds related to Spontaneous Pneumothorax according to GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1luminol4310.0CCL11, SOD1
2biliverdin43 2411.0HMOX1, BLVRA
3ptio439.9HMOX1, SOD1
43-nitrotyrosine439.9HMOX1, SOD1
5deta nonoate439.8HMOX1, HIF1A
6psgag439.8ELANE, CD36
7trolox439.8HIF1A, SOD1, HMOX1
8s-nitroso-n-acetylpenicillamine439.7HIF1A, SOD1, HMOX1
9gsno439.7HIF1A, SOD1, HMOX1
10rotenone439.7HIF1A, SOD1, HMOX1
11manganese superoxide439.7HIF1A, SOD1, HMOX1
1215-deoxy-delta-12,14-prostaglandin j2439.6CD36, HMOX1, CCL11
13pdtc439.6HMOX1, SOD1, HIF1A
14dihydrolipoic acid43 1210.5SOD1, ELANE
15nitroglycerin43 1210.5ELANE, SOD1, HIF1A
16deferoxamine43 1210.5HIF1A, SOD1, FTMT, HMOX1
17endotoxin439.5LBP, ELANE, FTMT, CCL11
18alpha lipoic acid439.5HMOX1, SOD1, SERPINA1
19peroxynitrite439.4SERPINA1, SOD1, CCL11
20rottlerin439.4ELANE, HMOX1, CD36
21n acetylcysteine439.4HMOX1, CCL11, SOD1, HIF1A
22hocl439.4SERPINA1, SOD1, ELANE
23actinomycin d439.3LBP, HIF1A, CCL11, HMOX1
24sb 20358043 5910.3HIF1A, CCL11, HMOX1, CD36
25sodium nitroprusside439.3HMOX1, ELANE, SOD1, HIF1A
26resveratrol43 59 24 1212.2HMOX1, SOD1, HIF1A
27egcg439.2HIF1A, SOD1, ELANE, HMOX1
28ly294002439.2HIF1A, CCL11, HMOX1, CD36
29adriamycin439.2CD36, SOD1, HIF1A
30alpha tocopherol439.1CD36, HMOX1, ELANE, SOD1
31cyclosporin a43 28 5911.0HIF1A, ELANE, CCL11, HMOX1
32desmosine439.0ELANE, SERPINA1, FBN1
33dexamethasone43 49 28 1211.9LBP, HIF1A, CCL11, HMOX1, CD36
34iron43 249.9HMOX1, FTMT, SOD1, SERPINA1, HIF1A
35nadph43 249.9BLVRA, HIF1A, SERPINA1, SOD1, HMOX1
36pge2438.8HIF1A, ELANE, CCL11, HMOX1, CD36
37vegf438.7FBLN5, HIF1A, CCL11, HMOX1, CD36
38hyaluronic acid43 249.7CD36, CCL11, ELANE, FBN1
39superoxide43 249.6LBP, HIF1A, SOD1, ELANE, CCL11, HMOX1
40lactate438.5HIF1A, SOD1, ELANE, HMOX1
41nitric oxide43 24 1210.5LBP, HIF1A, SERPINA1, SOD1, CCL11, HMOX1
42alanine438.3LBP, FBN1, HIF1A, SOD1, CCL11, HMOX1
43h2o2438.1HIF1A, SERPINA1, SOD1, ELANE, HMOX1, CD36
44retinoic acid43 249.0FBN1, HIF1A, ELANE, CCL11, HMOX1, CD36
45ascorbic acid43 248.8FBN1, HIF1A, SERPINA1, SOD1, HMOX1, CD36
46heparin43 28 24 1210.8LBP, FBN1, SERPINA1, ELANE, CCL11, CD36
47estrogen437.7FBN1, HIF1A, SERPINA1, ELANE, HMOX1, CD36
48serine437.4LBP, BLVRA, FBN1, HIF1A, SERPINA1, ELANE
49cysteine437.3FBN1, HIF1A, SERPINA1, SOD1, ELANE, HMOX1
50oxygen43 247.7HMOX1, LBP, BLVRA, FBN1, HIF1A, SERPINA1

GO Terms for genes affiliated with Spontaneous Pneumothorax

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Cellular components related to Spontaneous Pneumothorax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.7SOD1, FBLN5, FBN1
2extracellular vesicular exosomeGO:00700628.3ELANE, SOD1, SERPINA1, BLVRA, LBP
3proteinaceous extracellular matrixGO:00055788.3FBN1, FBLN5, SERPINA1
4extracellular spaceGO:00056157.3HMOX1, LBP, FBN1, FBLN5, SERPINA1, SOD1
5extracellular regionGO:00055767.0LBP, FBN1, FBLN5, SERPINA1, SOD1, ELANE

Biological processes related to Spontaneous Pneumothorax according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1heme catabolic processGO:004216710.2HMOX1, BLVRA
2regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:004361910.1HMOX1, HIF1A
3porphyrin-containing compound metabolic processGO:000677810.0HMOX1, BLVRA
4negative regulation of TOR signalingGO:003200710.0FLCN, HIF1A
5positive regulation of chemokine productionGO:003272210.0HIF1A, LBP
6cellular response to lipoteichoic acidGO:00712239.9CD36, LBP
7muscle cell cellular homeostasisGO:00467169.9HIF1A, SOD1
8low-density lipoprotein particle clearanceGO:00343839.9CD36, HMOX1
9regulation of removal of superoxide radicalsGO:020001219.8FBLN5, CD36
10positive regulation of angiogenesisGO:00457669.7HIF1A, CCL11, HMOX1
11defense response to Gram-positive bacteriumGO:00508309.7CD36, LBP
12positive regulation of tumor necrosis factor productionGO:00327609.7CD36, LBP
13negative regulation of neuron apoptotic processGO:00435249.6HIF1A, SOD1, HMOX1
14positive regulation of smooth muscle cell proliferationGO:00486619.6HMOX1, ELANE
15acute-phase responseGO:00069539.5LBP, SERPINA1
16positive regulation of interleukin-6 productionGO:00327559.5CD36, LBP
17negative regulation of growth of symbiont in hostGO:00441309.5CD36, ELANE, LBP
18cellular iron ion homeostasisGO:00068799.4HMOX1, FTMT, SOD1, HIF1A
19response to hydrogen peroxideGO:00425429.4HMOX1, SOD1
20response to lipopolysaccharideGO:00324969.3LBP, SERPINA1, ELANE
21platelet degranulationGO:00025769.2SERPINA1, SOD1, CD36
22platelet activationGO:00301689.1SERPINA1, SOD1, CD36

Molecular functions related to Spontaneous Pneumothorax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.4CCL11, ELANE, FLCN, SOD1, SERPINA1, HIF1A

Products for genes affiliated with Spontaneous Pneumothorax

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Sources for Spontaneous Pneumothorax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet