MCID: SPR009
MIFTS: 41

Sporadic Breast Cancer malady

Genetic diseases, Cancer diseases, Rare diseases, Reproductive diseases categories

Aliases & Classifications for Sporadic Breast Cancer

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Aliases & Descriptions for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 10 12
 
Sporadic Breast Carcinoma 65


Classifications:



External Ids:

Disease Ontology10 DOID:8029
NCIt42 C7566

Summaries for Sporadic Breast Cancer

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MalaCards based summary: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to cowden disease and breast cancer. An important gene associated with Sporadic Breast Cancer is C11orf30 (Chromosome 11 Open Reading Frame 30), and among its related pathways are PLK3 signaling events and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include breast and endothelial, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Sporadic Breast Cancer

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Diseases in the Breast Cancer family:

sporadic breast cancer Inflammatory Breast Carcinoma
Breast Benign Neoplasm Breast Carcinoma in Situ
Familial Breast Cancer Bard1-Related Susceptibility to Breast Cancer
Brip1-Related Breast Cancer Chek2-Related Susceptibility to Breast Cancer
Rad51-Related Susceptibility to Breast Cancer

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1cowden disease30.5PGR, TP53
2breast cancer30.2ATM, BARD1, BRCA1, BRCA2, C11orf30, CHEK2
3congenital pulmonary veins atresia or stenosis10.4BRCA1, BRCA2
4bronchiolitis obliterans10.3BRCA1, BRCA2
5vulvar melanoma10.3ESR1, PGR
6childhood teratocarcinoma of the testis10.3ESR1, PGR
7rectum rhabdomyosarcoma10.3ESR1, PGR
8vestibulocochlear nerve disease10.3ESR1, PGR
9vulvar disease10.3ESR1, PGR
10vulvar sarcoma10.3ESR1, PGR
11heart leiomyosarcoma10.3ERBB2, ESR1
12tuberous sclerosis10.3ESR1, PGR
13central nervous system leiomyosarcoma10.3ESR1, TP53
14pancreatic islet cell tumors10.3BRCA1, BRCA2, TP53
15animal phobia10.3BRCA1, BRCA2, PGR
16nutritional deficiency disease10.3BRCA1, BRCA2, PGR
17amyloid tumor10.3BRCA1, BRCA2, TP53
18microcystic variant infiltrating bladder urothelial carcinoma10.3BRCA1, BRCA2, PGR
19breast sarcoma10.3ERBB2, TP53
20ciliopathy10.3BRCA1, BRCA2, TP53
21ovarian clear cell adenofibroma10.3BRCA1, BRCA2, TP53
22extrahepatic bile duct small cell adenocarcinoma10.3BRCA1, BRCA2, ERBB2
23sarcomatoid basal cell carcinoma10.3ESR1, PGR
24enophthalmos10.3ERBB2, PGR
25congenital disorder of glycosylation, type if10.3ERBB2, TP53
26spinal meninges cancer10.3BRCA2, ESR1, ESR2
27metachronous kidney wilms' tumor10.2ESR1, PGR, TP53
28ovarian cancer, somatic10.2BRCA1, BRCA2, ERBB2
29liddle syndrome, scnn1b-related10.2CHEK2, TP53
30oxyphilic endometrial endometrioid adenocarcinoma10.2ESR1, PGR, TP53
31breast mucinous carcinoma10.2ERBB2, PGR
32progesterone resistance10.2ESR1, ESR2, PGR
33cervical mucinous adenocarcinoma10.2ESR1, PGR, TP53
34biliary tract intraductal papillary mucinous neoplasm10.2ATM, BRCA1, TP53
35endotheliitis10.2
36steatitis10.2ESR1, PGR, TP53
37germ cell and embryonal cancer10.2ESR1, ESR2, PGR
38endometriosis in scar of skin10.2ESR1, ESR2, PGR
39bartonellosis10.2ESR1, PGR
40estrogen-receptor negative breast cancer10.2ERBB2, PGR
41glaucoma iridogoniodysgenesia10.2ERBB2, ESR1, PGR
42anus lymphoma10.2ESR1, PGR
43ciliary body disease10.2ERBB2, ESR1
44malignant cystic nephroma10.2ERBB2, ESR1, PGR
45breast granular cell tumor10.2ERBB2, ESR1, ESR2
46vagina leiomyosarcoma10.2ERBB2, ESR1, PGR
47esophageal adenoid cystic carcinoma10.2ERBB2, ESR1, PGR
48high molecular weight kininogen deficiency10.2ERBB2, ESR1, TP53
49rectum neuroendocrine neoplasm10.2ESR2, PGR, TP53
50adolescence-adult electroclinical syndrome10.2ERBB2, ESR1, PGR

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to sporadic breast cancer

Symptoms for Sporadic Breast Cancer

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Drugs & Therapeutics for Sporadic Breast Cancer

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Drugs for Sporadic Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Pregabalinapproved, illicit, investigationalPhase 2327148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
2
PaclitaxelapprovedPhase 2250533069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
3Calcium, DietaryPhase 23529
4
CarboplatinapprovedPhase 1181241575-94-410339178, 498142, 38904, 38904, 498142
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)
5
Lapatinibapproved, investigational, Approved March 2007Phase 0292231277-92-2, 388082-78-8208908, 9941095
Synonyms:
1xkk
231277-92-2
388082-78-8
4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
AB1004631
AC-1314
AC1L4LL4
AKOS005145766
CHEBI:49603
CHEMBL1201179
CHEMBL554
CID11557040
CID208908
D04024
D08108
DB01259
DB02584
EN002712
FMM
GSK 572016
GSK572016
GW 572016
GW 572016X
GW-2016
GW-572016
GW-572016F
GW2016
GW572016
HMS2089H10
I01-1247
 
Kinome_3684
Kinome_3685
LAPATINIB DITOSYLATE MONOHYDRATE
LS-187029
LS-187771
Lapatinib
Lapatinib (INN)
Lapatinib Ditosylate
Lapatinib [INN]
Lapatinib ditosylate
Lapatinib ditosylate (USAN)
Lapatinib tosilate hydrate
Lapatinib tosilate hydrate (JAN)
Lapatinib, Tykerb, GW572016
N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine
N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
NCGC00167507-01
NSC745750
TL80090051
Tycerb
Tykerb
Tykerb (TN)
Tyverb
UNII-0VUA21238F
lapatinib
lapatinib ditosylate
nchembio866-comp20
6Insulin, Globin Zinc4069
7insulin4069

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast CancerCompletedNCT00600275Phase 1, Phase 2
2Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-MyalgiaNot yet recruitingNCT02024568Phase 2
3AZD2281 Plus Carboplatin to Treat Breast and Ovarian CancerActive, not recruitingNCT01445418Phase 1
4Insulin Resistance and Breast CancerCompletedNCT00304941
5Metabolic Syndrome as Modifiable Risk Factor for Breast CancerRecruitingNCT01172886
6Concentration and Activity of Lapatinib in Vestibular SchwannomasRecruitingNCT00863122Phase 0
7Feasibility of Lifestyle Intervention in BRCA1/2 Mutation CarriersActive, not recruitingNCT02087592
8Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary PresentationNot yet recruitingNCT02664389

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

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Anatomical Context for Sporadic Breast Cancer

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MalaCards organs/tissues related to Sporadic Breast Cancer:

33
Breast, Endothelial

Animal Models for Sporadic Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Sporadic Breast Cancer:

38 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8BRCA1, BRCA2, ERBB2, ESR1, ESR2, PTEN
2MP:00053698.7BRCA1, ERBB2, ESR1, ESR2, PGR, PTEN
3MP:00053908.6BRCA1, BRCA2, ERBB2, ESR1, ESR2, PGR
4MP:00107718.4BRCA1, BRCA2, ERBB2, ESR1, ESR2, PGR
5MP:00053718.1BRCA1, BRCA2, ERBB2, ESR1, ESR2, FANCD2
6MP:00028737.8BARD1, BRCA1, BRCA2, ERBB2, ESR2, PGR
7MP:00053877.4ATM, BRCA1, BRCA2, CHEK2, ESR1, ESR2
8MP:00053977.4ATM, BRCA1, BRCA2, CHEK2, ESR1, ESR2
9MP:00053797.3ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
10MP:00053807.2ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
11MP:00053897.0ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
12MP:00053786.5ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
13MP:00053866.4ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
14MP:00036316.2ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
15MP:00020066.2ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
16MP:00107686.0ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
17MP:00053845.5ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
18MP:00053765.5BRCA1, BRCA2, CHEK2, ERBB2, ESR1, ESR2

Publications for Sporadic Breast Cancer

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Articles related to Sporadic Breast Cancer:

(show top 50)    (show all 255)
idTitleAuthorsYear
1
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer. (26430163)
2015
2
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. (24556691)
2014
3
HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women. (23976978)
2013
4
MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. (23860775)
2013
5
Imaging features of sporadic breast cancer in women under 40 years old: 97 cases. (23918218)
2013
6
Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. (23063927)
2013
7
The neurofibromin 1 type I isoform predominance characterises female population affected by sporadic breast cancer: preliminary data. (22412049)
2012
8
Quantification of PKC family genes in sporadic breast cancer by qRT-PCR: evidence that PKCI^/I> overexpression is an independent prognostic factor. (22511072)
2012
9
The TP53 gene polymorphisms and survival of sporadic breast cancer patients. (21365326)
2012
10
Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China. (21912605)
2011
11
Familial and sporadic breast cancers: differences in clinical, histopathological, and immunohistochemical features. (20308044)
2011
12
Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. (21113649)
2011
13
BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer. (20877436)
2010
14
Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor. (20043118)
2010
15
AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers. (21321378)
2010
16
Expression of FANCD2 in sporadic breast cancer and clinicopathological analysis. (20556575)
2010
17
A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (19937980)
2010
18
Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer. (20193849)
2010
19
Silencing of estrogen receptor alpha (ERalpha) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer. (18814026)
2009
20
Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (19765277)
2009
21
Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. (17952592)
2008
22
Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer. (18711133)
2008
23
Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. (18425370)
2008
24
Analysis of loss of heterozygosity and immunohistochemistry in BRCA1 gene in sporadic breast cancers. (16718381)
2006
25
FANCD2 associated with sporadic breast cancer risk. (16679306)
2006
26
Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. (17011986)
2006
27
A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk. (16103107)
2005
28
Sporadic breast cancer among relatives of BRCA mutation carriers. (16301869)
2005
29
Significant involvement of CCR2-64I and CXCL12-3a in the development of sporadic breast cancer. (15121787)
2004
30
BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. (15365993)
2004
31
The association of NAT2 polymorphisms with sporadic breast cancer]. (15285615)
2004
32
A role for BRCA1 in sporadic breast cancer. (12698194)
2003
33
Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. (12888106)
2003
34
Clustering of variations and haplotype analysis in the highly variable region of exon 11 of BRCA1 in Chinese women with sporadic breast cancer. (12402341)
2002
35
Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. (12406554)
2002
36
Microsatellite instability correlates with negative expression of estrogen and progesterone receptors in sporadic breast cancer. (10992275)
2000
37
Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. (11071387)
2000
38
Association of A vitamin D receptor polymorphism with sporadic breast cancer development. (10597185)
1999
39
Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (10534407)
1999
40
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. (9537235)
1998
41
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. (9872332)
1998
42
Construction of a high-resolution physical and transcription map of chromosome 16q24.3: a region of frequent loss of heterozygosity in sporadic breast cancer. (9628816)
1998
43
Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient. (9665150)
1998
44
The genetics of sporadic breast cancer. (9108590)
1997
45
Microsatellite instability in early sporadic breast cancer. (8645585)
1996
46
Frequent allele loss on 9p21-22 defines a smallest common region in the vicinity of the CDKN2 gene in sporadic breast cancer. (8889502)
1996
47
Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer. (8616837)
1996
48
Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. (8589680)
1995
49
Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. (7795653)
1995
50
Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development. (8181852)
1994

Variations for Sporadic Breast Cancer

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Expression for genes affiliated with Sporadic Breast Cancer

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Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for genes affiliated with Sporadic Breast Cancer

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Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CHEK2, TP53
29.9ESR1, ESR2
39.7ATM, BRCA1, TP53
49.7ATM, BRCA1, TP53
59.6ATM, BRCA2, RAD51
6
Show member pathways
9.6ESR1, ESR2, PGR
79.6ATM, CHEK2, TP53
8
Show member pathways
9.6ATM, CHEK2, TP53
99.6ATM, ESR2, PGR
109.5ERBB2, PTEN, TP53
119.5ERBB2, PTEN, TP53
12
Show member pathways
9.4ATM, BRCA1, BRCA2, RAD51
13
Show member pathways
9.4BRCA1, CHEK2, ESR1, PGR
14
Show member pathways
9.4BRCA2, ERBB2, RAD51, TP53
159.4ATM, BRCA1, XRCC1
16
Show member pathways
9.3ATM, CHEK2, ERBB2, TP53
17
Show member pathways
9.2BRCA1, BRCA2, FANCD2, RAD51
18
Wnt Signaling Pathway (WikiPathways)
Show member pathways
9.2BRCA1, BRCA2, FANCD2, RAD51
199.0BRCA2, CHEK2, ESR1, XRCC1
20
Show member pathways
9.0ATM, BARD1, BRCA1, BRCA2, RAD51
21
Show member pathways
9.0ATM, BARD1, BRCA1, BRCA2, RAD51
228.9ATM, BRCA1, ERBB2, PTEN, TP53
23
Show member pathways
8.9ATM, BRCA1, CHEK2, PTEN, TP53
248.9BRCA2, ERBB2, PTEN, RAD51, TP53
25
Show member pathways
8.7ATM, BRCA1, BRCA2, ERBB2, PTEN, TP53
26
Show member pathways
8.5ATM, BRCA1, CHEK2, FANCD2, RAD51, TP53
27
Show member pathways
8.5ATM, BARD1, BRCA1, CHEK2, PTEN, TP53
288.5ATM, BARD1, BRCA1, FANCD2, RAD51, TP53
298.4ATM, BARD1, BRCA1, CHEK2, FANCD2, TP53
30
Show member pathways
8.4ATM, BARD1, BRCA1, BRCA2, CHEK2, RAD51
318.2ATM, BRCA1, BRCA2, CHEK2, RAD51, TP53
32
Show member pathways
8.1ATM, BRCA1, CHEK2, FANCD2, PTEN, RAD51
33
Show member pathways
7.9ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
347.9ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
357.7ATM, BARD1, BRCA1, BRCA2, CHEK2, ESR1
367.4ATM, BRCA1, BRCA2, CHEK2, ERBB2, ESR1
37
Show member pathways
7.3ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
38
Show member pathways
7.1ATM, BRCA1, CHEK2, ERBB2, ESR1, ESR2
39
Show member pathways
6.6ATM, BARD1, BRCA1, BRCA2, CHEK2, ESR1

GO Terms for genes affiliated with Sporadic Breast Cancer

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Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-BARD1 complexGO:003143610.6BARD1, BRCA1
2BRCA1-A complexGO:007053110.5BARD1, BRCA1
3condensed chromosomeGO:00007939.9BRCA1, FANCD2, RAD51
4PML bodyGO:00166059.6CHEK2, PTEN, RAD51, TP53
5nucleusGO:00056346.0ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
6nucleoplasmGO:00056545.6ATM, BARD1, BRCA1, BRCA2, C11orf30, CHEK2

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1chordate embryonic developmentGO:004300910.6BRCA1, BRCA2
2protein K6-linked ubiquitinationGO:008502010.6BARD1, BRCA1
3determination of adult lifespanGO:000834010.5ATM, TP53
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.3BRCA1, BRCA2, TP53
5chromosome breakageGO:003105210.3BRCA1, BRCA2, TP53
6DNA recombinationGO:000631010.3BRCA1, BRCA2, RAD51
7DNA damage induced protein phosphorylationGO:000697510.3ATM, CHEK2
8replicative senescenceGO:009039910.2ATM, CHEK2, TP53
9steroid hormone mediated signaling pathwayGO:004340110.2ESR1, ESR2, PGR
10response to X-rayGO:001016510.2BRCA2, RAD51, TP53
11positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9ESR1, ESR2, PTEN
12double-strand break repair via nonhomologous end joiningGO:00063039.9ATM, BARD1, BRCA1
13intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.8ATM, BRCA1, BRCA2, CHEK2
14response to gamma radiationGO:00103329.7BRCA2, CHEK2, FANCD2, TP53
15response to estradiolGO:00323559.4BRCA2, ESR1, PTEN
16transcription initiation from RNA polymerase II promoterGO:00063679.3ESR1, ESR2, PGR, PTEN, TP53
17double-strand break repair via synthesis-dependent strand annealingGO:00450039.3ATM, BARD1, BRCA1, BRCA2, RAD51
18positive regulation of transcription, DNA-templatedGO:00458939.1BRCA1, BRCA2, CHEK2, ESR1, ESR2, TP53
19double-strand break repair via homologous recombinationGO:00007248.7ATM, BARD1, BRCA1, BRCA2, RAD51, XRCC1
20transcription, DNA-templatedGO:00063518.3BRCA1, C11orf30, CHEK2, ERBB2, ESR1, ESR2
21response to drugGO:00424938.2ERBB2, PTEN, RAD51, TP53, XRCC1
22double-strand break repairGO:00063028.0ATM, BARD1, BRCA1, BRCA2, CHEK2, RAD51
23cellular response to DNA damage stimulusGO:00069747.3ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
24DNA repairGO:00062817.2ATM, BARD1, BRCA1, BRCA2, C11orf30, CHEK2

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1estrogen receptor activityGO:003028410.7ESR1, ESR2
2estrogen response element bindingGO:003405610.7ESR1, ESR2
3steroid hormone receptor activityGO:000370710.3ESR1, ESR2, PGR
4RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:000487910.3ESR1, ESR2, PGR
5DNA polymerase bindingGO:007018210.2FANCD2, RAD51
6steroid bindingGO:000549610.2ESR1, ESR2, PGR
7core promoter sequence-specific DNA bindingGO:000104610.2ESR1, ESR2, TP53
8ubiquitin protein ligase bindingGO:00316259.9BRCA1, CHEK2, ERBB2, TP53
9damaged DNA bindingGO:00036849.8BRCA1, TP53, XRCC1
10identical protein bindingGO:00428028.8CHEK2, ERBB2, ESR1, PTEN, RAD51, TP53
11enzyme bindingGO:00198997.9BRCA1, ESR1, ESR2, GSTM1, PGR, PTEN
12protein bindingGO:00055154.7ATM, BARD1, BRCA1, BRCA2, C11orf30, CHEK2

Sources for Sporadic Breast Cancer

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet