MCID: SPR009
MIFTS: 47

Sporadic Breast Cancer

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Genetic diseases

Aliases & Classifications for Sporadic Breast Cancer

MalaCards integrated aliases for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 12 14
Sporadic Breast Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8029
NCIt 46 C7566
UMLS 69 C1336076

Summaries for Sporadic Breast Cancer

MalaCards based summary : Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to cowden disease and fanconi anemia, complementation group d2. An important gene associated with Sporadic Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are ERK Signaling and Gene Expression. Affiliated tissues include breast and endothelial, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Sporadic Breast Cancer

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 cowden disease 29.9 BRCA1 BRCA2 PTEN
2 fanconi anemia, complementation group d2 29.8 BRCA2 FANCD2 RAD51
3 mutagen sensitivity 29.7 BRCA1 BRCA2 TP53 XRCC1
4 breast disease 29.4 ERBB2 ESR1 ESR2 PGR TP53
5 bilateral breast cancer 27.9 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
6 ovarian cancer 26.7 BARD1 BRCA1 BRCA2 CHEK2 EMSY ERBB2
7 breast cancer 26.6 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
8 hereditary site-specific ovarian cancer syndrome 10.6 BRCA1 BRCA2
9 brca1 hereditary breast and ovarian cancer syndrome 10.6 BRCA1 BRCA2
10 breast reconstruction 10.6 BRCA1 BRCA2
11 breast-ovarian cancer, familial 1 10.5 BRCA1 BRCA2
12 endometrial clear cell adenocarcinoma 10.5 ESR1 TP53
13 vulvar syringoma 10.5 ESR1 PGR
14 lung leiomyoma 10.5 ESR1 PGR
15 endometrium carcinoma in situ 10.5 PGR TP53
16 vulvar benign neoplasm 10.5 ESR1 PGR
17 trigonitis 10.5 ESR1 PGR
18 vulvar leiomyoma 10.5 ESR1 PGR
19 scirrhous adenocarcinoma 10.4 ERBB2 PGR
20 breast apocrine carcinoma 10.4 ERBB2 PGR
21 predominantly cortical thymoma 10.4 ESR1 PGR
22 nosophobia 10.4 BRCA1 BRCA2 PGR
23 cancerophobia 10.4 BRCA1 BRCA2 PGR
24 tetraploidy 10.4 BRCA2 TP53
25 tuberculous salpingitis 10.4 BRCA1 BRCA2 ERBB2
26 dysgerminoma of ovary 10.4 BRCA1 BRCA2 PGR
27 breast duct papilloma 10.4 PGR PTEN
28 vestibular gland benign neoplasm 10.4 ESR1 PGR TP53
29 postmenopausal atrophic vaginitis 10.4 ESR1 ESR2
30 bartholin's gland adenoma 10.4 ESR1 PGR TP53
31 papillary serous adenocarcinoma 10.4 BRCA1 PGR TP53
32 comedo carcinoma 10.4 ERBB2 ESR1
33 bartholin's gland benign neoplasm 10.4 ESR1 PGR TP53
34 cervical carcinosarcoma 10.4 ESR1 PGR TP53
35 progesterone resistance 10.4 ESR1 ESR2 PGR
36 intracystic papillary adenoma 10.4 ERBB2 PGR
37 adenosarcoma 10.4 ESR1 PGR TP53
38 gender identity disorder 10.4 ESR1 ESR2 PGR
39 myxosarcoma 10.4 ATM BRCA1 TP53
40 estrogen excess 10.3 ESR1 ESR2 PGR
41 endometriosis of ovary 10.3 ESR1 ESR2 PGR
42 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
43 glioma susceptibility 1 10.3 ERBB2 TP53
44 breast malignant phyllodes tumor 10.3 PGR TP53
45 glassy cell carcinoma of the cervix 10.3 ERBB2 ESR1 PGR
46 lynch syndrome i 10.3 BRCA1 BRCA2
47 breast scirrhous carcinoma 10.3 ERBB2 ESR1 PGR
48 olfactory groove meningioma 10.3 PGR TP53
49 oncocytic breast carcinoma 10.3 ERBB2 ESR1 PGR
50 hidradenocarcinoma 10.3 ERBB2 ESR1 TP53

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer

Symptoms & Phenotypes for Sporadic Breast Cancer

GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

25 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.7 RAD51 BARD1 BRCA1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.7 RAD51 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.7 RAD51 PGR BARD1 BRCA2 BRCA1
4 Decreased homologous recombination repair frequency GR00236-A-2 10.7 RAD51 PGR BARD1 BRCA2 BRCA1 ATM
5 Decreased homologous recombination repair frequency GR00236-A-3 10.7 BRCA2 RAD51 BARD1 BRCA1
6 Decreased ionizing radiation sensitivity GR00232-A-1 10.01 TTC4 PGR BRCA2 ESR2 FANCD2 BARD1
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 PTEN XRCC1 CHEK2 FANCD2 TP53 BRCA2
8 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 PTEN XRCC1 RAD51 CHEK2 FANCD2 TP53
9 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.81 XRCC1 RAD51 CHEK2 FANCD2 TP53 BRCA1
10 Increased cell death HMECs cells GR00103-A-0 9.73 PTEN RAD51 PGR TP53 TTC4 BRCA1
11 Decreased viability with cisplatin GR00101-A-4 9.62 RAD51 BRCA2 BRCA1 BARD1
12 Decreased viability after ionizing radiation GR00232-A-2 9.54 BRCA2 ATM BRCA1
13 Synthetic lethal with cisplatin GR00101-A-1 9.26 RAD51 BRCA2 BRCA1 BARD1

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 ESR1 CHEK2 ERBB2 ESR2 PGR RAD51
2 behavior/neurological MP:0005386 10.31 ERBB2 ESR2 ESR1 PTEN PGR FANCD2
3 growth/size/body region MP:0005378 10.29 ERBB2 ESR2 ESR1 RAD51 FANCD2 PTEN
4 homeostasis/metabolism MP:0005376 10.29 ESR2 ESR1 CHEK2 ERBB2 PGR FANCD2
5 embryo MP:0005380 10.28 ESR1 ERBB2 PGR RAD51 PTEN XRCC1
6 endocrine/exocrine gland MP:0005379 10.26 ESR1 CHEK2 ERBB2 ESR2 PGR FANCD2
7 hematopoietic system MP:0005397 10.24 ESR2 CHEK2 ESR1 PTEN PGR FANCD2
8 mortality/aging MP:0010768 10.24 ESR1 CHEK2 ERBB2 ESR2 PGR RAD51
9 immune system MP:0005387 10.2 ESR2 CHEK2 ESR1 FHIT PTEN PGR
10 digestive/alimentary MP:0005381 10.15 ERBB2 ESR2 ESR1 PTEN FHIT TP53
11 integument MP:0010771 10.13 ESR1 ERBB2 ESR2 PGR PTEN FHIT
12 neoplasm MP:0002006 10.1 ESR1 ERBB2 ESR2 PGR FANCD2 PTEN
13 limbs/digits/tail MP:0005371 10.06 ESR1 ERBB2 ESR2 PGR FANCD2 PTEN
14 adipose tissue MP:0005375 10.05 ESR2 ESR1 PTEN TP53 BRCA1 ATM
15 nervous system MP:0003631 9.93 ESR2 ESR1 CHEK2 ERBB2 FANCD2 PTEN
16 muscle MP:0005369 9.87 ERBB2 ESR1 PTEN ESR2 PGR TP53
17 normal MP:0002873 9.65 ESR2 ESR1 ERBB2 PGR PTEN XRCC1
18 reproductive system MP:0005389 9.32 ESR2 ESR1 ERBB2 PGR FANCD2 PTEN

Drugs & Therapeutics for Sporadic Breast Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer Unknown status NCT01172886
2 Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers Active, not recruiting NCT02087592

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

MalaCards organs/tissues related to Sporadic Breast Cancer:

38
Breast, Endothelial

Publications for Sporadic Breast Cancer

Articles related to Sporadic Breast Cancer:

(show top 50) (show all 285)
# Title Authors Year
1
Genetic determinants of sporadic breast cancer in Sri Lankan women. ( 29433565 )
2018
2
Distinct role of endothelial nitric oxide synthase gene polymorphisms from menopausal status in the patients with sporadic breast cancer in Taiwan. ( 29102546 )
2018
3
Cost-effectiveness Analysis of Contralateral Prophylactic Mastectomy Compared to Unilateral Mastectomy with Routine Surveillance for Unilateral, Sporadic Breast Cancer. ( 29039025 )
2017
4
Simultaneous ATM/BRCA1/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients. ( 28058614 )
2017
5
TGFbeta and miRNA regulation in familial and sporadic breast cancer. ( 28881597 )
2017
6
Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. ( 28190851 )
2017
7
Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53. ( 28630214 )
2017
8
Variants of estrogen receptor alpha and beta genes modify the severity of sporadic breast cancer. ( 28109853 )
2017
9
Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer. ( 29146938 )
2017
10
Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers. ( 27837030 )
2017
11
Can MTHFR C677T and A1298C Polymorphisms Alter the Risk and Severity of Sporadic Breast Cancer in Brazilian Women? ( 28330681 )
2017
12
A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility. ( 27668787 )
2016
13
Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. ( 27413552 )
2016
14
Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients. ( 26205471 )
2016
15
RECQL4 helicase has oncogenic potential in sporadic breast cancers. ( 26690729 )
2016
16
Twenty-one-gene recurrence score assay in BRCA-associated versus sporadic breast cancers: Differences based on germline mutation status. ( 26859126 )
2016
17
Association between genetic variants of EGF-containing fibulin-like extracellular matrix protein1 gene and sporadic breast cancer in a Chinese Han population. ( 27048115 )
2016
18
Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer. ( 26723934 )
2016
19
Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards. ( 27189832 )
2016
20
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility. ( 26650628 )
2016
21
Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1. ( 27039925 )
2016
22
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. ( 26754093 )
2016
23
ATM gene mutations in sporadic breast cancer patients from Brazil. ( 25625042 )
2015
24
First description of a sporadic breast cancer in a woman with BRCA1 germline mutation. ( 26426992 )
2015
25
Development and validation of molecular methodologies to assess PALB2 expression in sporadic breast cancer. ( 26526077 )
2015
26
Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China. ( 26535628 )
2015
27
Decreased Expression of BRCA2 Accelerates Sporadic Breast Cancer Progression. ( 27065665 )
2015
28
Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study. ( 26476291 )
2015
29
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer. ( 26430163 )
2015
30
Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. ( 26456802 )
2015
31
DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China. ( 25961110 )
2015
32
Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies. ( 26643130 )
2015
33
Promoter methylation and expression changes of BRCA1 in cancerous tissues of patients with sporadic breast cancer. ( 25789047 )
2015
34
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women. ( 26598080 )
2015
35
A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer. ( 26320393 )
2015
36
The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population. ( 25674498 )
2015
37
Assessing Heavy Metal and PCB Exposure from Tap Water by Measuring Levels in Plasma from Sporadic Breast Cancer Patients, a Pilot Study. ( 26690196 )
2015
38
A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. ( 25067956 )
2014
39
The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients. ( 24850984 )
2014
40
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. ( 24556691 )
2014
41
Association of TNF-I+, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women. ( 25010932 )
2014
42
Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers. ( 25342642 )
2014
43
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts. ( 25425972 )
2014
44
The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer. ( 24842653 )
2014
45
Association of +405C>G and +936C>T polymorphisms of the vascular endothelial growth factor gene with sporadic breast cancer in North Indians. ( 24528036 )
2014
46
BRCA1 gene exon 11 mutations in Uighur and Han women with early-onset sporadic breast cancer in the northwest region of China. ( 24969878 )
2014
47
Association of promoter methylation of ERI+ and ERI^ with sporadic breast cancer--a study from North India. ( 24833090 )
2014
48
Combined microRNA and ER expression: a new classifier for familial and sporadic breast cancer patients. ( 25406994 )
2014
49
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis. ( 24464625 )
2014
50
Potential clinical significance of ERI^ ON promoter methylation in sporadic breast cancer. ( 23794253 )
2013

Variations for Sporadic Breast Cancer

Expression for Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for Sporadic Breast Cancer

Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 ATM BRCA1 CHEK2 ERBB2 ESR1 ESR2
2
Show member pathways
13.79 ATM BARD1 BRCA1 CHEK2 ERBB2 ESR1
3
Show member pathways
13.41 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
13.18 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
5
Show member pathways
13.05 ATM BRCA1 BRCA2 ERBB2 FHIT PTEN
6
Show member pathways
12.95 ATM BARD1 BRCA1 CHEK2 FANCD2 PTEN
7
Show member pathways
12.89 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
8
Show member pathways
12.81 BARD1 BRCA1 ESR1 PTEN TP53
9 12.81 BRCA2 ERBB2 ESR1 ESR2 PTEN RAD51
10
Show member pathways
12.76 BRCA1 BRCA2 ERBB2 ESR1 ESR2 PGR
11
Show member pathways
12.64 ATM BARD1 BRCA1 CHEK2 TP53
12 12.52 ATM BRCA1 ERBB2 PTEN TP53
13 12.5 ATM BRCA1 BRCA2 CHEK2 FANCD2 RAD51
14
Show member pathways
12.47 ATM BRCA1 BRCA2 RAD51
15
Show member pathways
12.46 ERBB2 ESR1 ESR2 PTEN
16
Show member pathways
12.42 ATM CHEK2 ERBB2 TP53
17
Show member pathways
12.38 ATM BRCA1 CHEK2 FANCD2 PTEN RAD51
18
Show member pathways
12.36 ATM BARD1 BRCA1 CHEK2 TP53
19
Show member pathways
12.29 ATM BARD1 BRCA1 BRCA2 RAD51
20
Show member pathways
12.24 ATM BRCA1 CHEK2 PTEN TP53
21
Show member pathways
12.23 BRCA1 CHEK2 ESR1 PGR
22 12.17 ATM CHEK2 PTEN TP53
23
Show member pathways
12.15 BRCA2 ERBB2 RAD51 TP53
24
Show member pathways
12.14 ATM BARD1 BRCA1 BRCA2 RAD51
25 12.07 ATM CHEK2 PTEN TP53
26 12 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
27 11.99 ATM ERBB2 PTEN TP53
28
Show member pathways
11.97 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
29
Show member pathways
11.92 ERBB2 ESR1 PGR
30 11.9 BRCA1 BRCA2 FANCD2 RAD51
31
Show member pathways
11.87 ATM BRCA1 CHEK2 FANCD2 RAD51 TP53
32 11.84 FHIT PTEN TP53
33
Show member pathways
11.83 ESR1 ESR2 PGR
34 11.74 ATM BRCA1 ERBB2 TP53
35 11.73 ATM BRCA1 XRCC1
36
Show member pathways
11.73 ATM CHEK2 TP53
37 11.7 ATM BRCA1 CHEK2 ERBB2 PTEN TP53
38 11.67 ERBB2 PTEN TP53
39 11.63 ATM CHEK2 TP53
40 11.51 ATM BARD1 BRCA1 CHEK2 PTEN TP53
41
Show member pathways
11.5 ATM CHEK2 TP53
42
Show member pathways
11.48 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
43 11.44 ATM BARD1 BRCA1 CHEK2 FANCD2 TP53
44 11.41 BRCA2 CHEK2 ESR1 XRCC1
45 11.4 ESR1 PTEN TP53
46 11.32 ATM BRCA1 TP53
47 11.31 ATM ESR2 PGR
48 11.2 ATM BARD1 BRCA1 FANCD2 RAD51 TP53
49 11.05 ATM BRCA1 TP53
50 10.37 CHEK2 TP53

GO Terms for Sporadic Breast Cancer

Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
2 nuclear chromatin GO:0000790 9.76 ESR1 RAD51 TP53 XRCC1
3 nuclear chromosome, telomeric region GO:0000784 9.71 ATM BRCA2 RAD51 XRCC1
4 PML body GO:0016605 9.56 CHEK2 PTEN RAD51 TP53
5 condensed chromosome GO:0000793 9.54 BRCA1 FANCD2 RAD51
6 nucleoplasm GO:0005654 9.47 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
7 BRCA1-A complex GO:0070531 9.43 BARD1 BRCA1
8 lateral element GO:0000800 9.33 BRCA1 BRCA2 RAD51
9 BRCA1-BARD1 complex GO:0031436 9.32 BARD1 BRCA1

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.98 ATM BRCA1 CHEK2 ESR1 TP53
2 protein deubiquitination GO:0016579 9.97 BARD1 BRCA1 ESR1 PTEN TP53
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.85 ESR1 ESR2 PTEN
4 regulation of signal transduction by p53 class mediator GO:1901796 9.85 ATM BARD1 BRCA1 CHEK2 TP53
5 DNA recombination GO:0006310 9.84 BRCA1 BRCA2 RAD51
6 double-strand break repair via nonhomologous end joining GO:0006303 9.81 ATM BARD1 BRCA1 XRCC1
7 double-strand break repair GO:0006302 9.8 BRCA1 BRCA2 CHEK2
8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.8 ATM CHEK2 TP53
9 steroid hormone mediated signaling pathway GO:0043401 9.79 ESR1 ESR2 PGR
10 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.78 ATM BRCA1 BRCA2 CHEK2
11 double-strand break repair via homologous recombination GO:0000724 9.77 ATM BRCA1 BRCA2 RAD51 XRCC1
12 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.73 BRCA2 CHEK2 TP53
13 response to gamma radiation GO:0010332 9.73 BRCA2 CHEK2 FANCD2 TP53
14 response to X-ray GO:0010165 9.71 BRCA2 RAD51 TP53
15 cellular response to gamma radiation GO:0071480 9.71 ATM CHEK2 RAD51 TP53
16 DNA double-strand break processing GO:0000729 9.7 ATM BARD1 BRCA1
17 replicative senescence GO:0090399 9.67 ATM CHEK2 TP53
18 response to inorganic substance GO:0010035 9.66 PTEN TP53
19 determination of adult lifespan GO:0008340 9.66 ATM TP53
20 telomere maintenance via recombination GO:0000722 9.65 BRCA2 RAD51
21 DNA synthesis involved in DNA repair GO:0000731 9.65 ATM BARD1 BRCA1 BRCA2 RAD51
22 DNA damage induced protein phosphorylation GO:0006975 9.64 ATM CHEK2
23 protein K6-linked ubiquitination GO:0085020 9.64 BARD1 BRCA1
24 chromosome organization involved in meiotic cell cycle GO:0070192 9.63 ATM RAD51
25 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.62 BRCA1 BRCA2 CHEK2 TP53
26 DNA repair GO:0006281 9.61 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
27 chordate embryonic development GO:0043009 9.6 BRCA1 BRCA2
28 replication-born double-strand break repair via sister chromatid exchange GO:1990414 9.58 RAD51 XRCC1
29 mitotic recombination-dependent replication fork processing GO:1990426 9.55 BRCA2 RAD51
30 strand displacement GO:0000732 9.55 ATM BARD1 BRCA1 BRCA2 RAD51
31 cellular response to DNA damage stimulus GO:0006974 9.32 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
32 regulation of transcription, DNA-templated GO:0006355 10.31 BRCA1 CHEK2 EMSY ERBB2 ESR1 ESR2
33 transcription, DNA-templated GO:0006351 10.3 BRCA1 CHEK2 EMSY ERBB2 ESR1 ESR2
34 apoptotic process GO:0006915 10.09 ATM BRCA1 CHEK2 FHIT PTEN TP53
35 cell cycle GO:0007049 10.08 ATM BRCA1 BRCA2 CHEK2 FANCD2 TP53
36 positive regulation of transcription, DNA-templated GO:0045893 10.07 BRCA1 BRCA2 CHEK2 ESR1 ESR2 TP53

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.88 ATM CHEK2 ERBB2 FHIT RAD51
2 ubiquitin protein ligase binding GO:0031625 9.86 BRCA1 CHEK2 FHIT TP53
3 lipid binding GO:0008289 9.84 ESR1 ESR2 PGR PTEN
4 protein C-terminus binding GO:0008022 9.81 BRCA2 ERBB2 RAD51 TP53
5 damaged DNA binding GO:0003684 9.7 BRCA1 TP53 XRCC1
6 steroid hormone receptor activity GO:0003707 9.67 ESR1 ESR2 PGR
7 core promoter sequence-specific DNA binding GO:0001046 9.61 ESR1 ESR2 TP53
8 DNA polymerase binding GO:0070182 9.55 FANCD2 RAD51
9 nuclear receptor activity GO:0004879 9.54 ESR1 ESR2 PGR
10 enzyme binding GO:0019899 9.5 BRCA1 ESR1 ESR2 PGR PTEN TP53
11 estrogen receptor activity GO:0030284 9.46 ESR1 ESR2
12 steroid binding GO:0005496 9.43 ESR1 ESR2 PGR
13 estrogen response element binding GO:0034056 9.4 ESR1 ESR2
14 identical protein binding GO:0042802 9.32 BRCA2 CHEK2 ERBB2 ESR1 ESR2 FHIT
15 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.16 ESR1 ESR2
16 protein binding GO:0005515 10.25 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY

Sources for Sporadic Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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