MCID: SPR009
MIFTS: 46

Sporadic Breast Cancer

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Sporadic Breast Cancer

MalaCards integrated aliases for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 12 14
Sporadic Breast Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8029
NCIt 47 C7566
UMLS 69 C1336076

Summaries for Sporadic Breast Cancer

MalaCards based summary : Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to primitive neuroectodermal tumor of the corpus uteri and baraitser-winter cerebrofrontofacial syndrome. An important gene associated with Sporadic Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are ERK Signaling and Gene Expression. The drugs Paclitaxel and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include breast and endothelial, and related phenotypes are Decreased homologous recombination repair frequency and cellular

Related Diseases for Sporadic Breast Cancer

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ
Brip1-Related Breast Cancer

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
id Related Disease Score Top Affiliating Genes
1 primitive neuroectodermal tumor of the corpus uteri 10.9 BRCA1 BRCA2
2 baraitser-winter cerebrofrontofacial syndrome 10.9 BRCA1 BRCA2
3 bronchopulmonary dysplasia 10.8 BRCA1 BRCA2
4 breast cancer 10.8
5 pancreatic cancer 4 10.8 BRCA1 BRCA2
6 fallopian tube clear cell adenocarcinoma 10.8 ESR1 TP53
7 bartholin's gland benign neoplasm 10.8 ESR1 PGR
8 gallbladder leiomyoma 10.8 ESR1 PGR
9 blastema predominant kidney wilms' tumor 10.7 PGR TP53
10 fallopian tube benign neoplasm 10.7 ESR1 PGR
11 paranasal sinus disease 10.7 ESR1 PGR
12 dartoic leiomyoma 10.7 ESR1 PGR
13 cataract 27, nuclear progressive 10.7 BRCA1 BRCA2
14 gastritis 10.7 ERBB2 PGR
15 autoimmune disease of blood 10.7 BRCA1 BRCA2 PGR
16 selective immunoglobulin deficiency disease 10.7 BRCA1 BRCA2 PGR
17 urinary bladder inverted papilloma 10.6 ESR1 PGR
18 thai symphalangism syndrome 10.6 BRCA2 TP53
19 cutaneous lupus erythematosus 10.6 BRCA1 BRCA2 ERBB2
20 nasal cavity squamous cell carcinoma 10.6 BRCA1 BRCA2 PGR
21 benign breast phyllodes tumor 10.6 PGR PTEN
22 central nervous system organ benign neoplasm 10.6 ESR1 PGR TP53
23 lung adenoma 10.6 ESR1 PGR TP53
24 congenital disorder of glycosylation, type if 10.6 ERBB2 TP53
25 intestinal perforation 10.6 ESR1 PGR TP53
26 nerve fibre bundle defect 10.6 ERBB2 ESR1
27 ovarian mesodermal adenosarcoma 10.6 ESR1 PGR TP53
28 deafness, autosomal dominant 8/12 10.6 ESR1 ESR2 PGR
29 ulceroglandular tularemia 10.6 ESR1 ESR2
30 leiomyoma cutis 10.5 PGR TP53
31 osteogenesis imperfecta 10.5 ESR1 ESR2 PGR
32 acute thyroiditis 10.5 ESR1 ESR2 PGR
33 skin sarcoma 10.5 ERBB2 PGR
34 perinatal jaundice due to hepatocellular damage 10.5 ESR1 ESR2 PGR
35 her2-receptor negative breast cancer 10.5 ERBB2 PGR
36 glaucoma, hereditary 10.5 ERBB2 ESR1 PGR
37 subglottis verrucous carcinoma 10.5 ERBB2 ESR1 PGR
38 hip subluxation 10.5 ERBB2 ESR1 TP53
39 gastric tubular adenocarcinoma 10.5 ERBB2 ESR1 PGR
40 breast sarcoma 10.5 ERBB2 ESR1 ESR2
41 gastroesophageal junction adenocarcinoma 10.5 ERBB2 ESR1 PGR
42 spondylolysis 10.5 ESR1 ESR2 PGR
43 kidney clear cell sarcoma 10.5 ERBB2 ESR1 PGR
44 dmd-related dilated cardiomyopathy 10.5 ERBB2 ESR1 PGR
45 tenosynovitis of foot and ankle 10.5 ESR2 PGR TP53
46 prostatic acinar adenocarcinoma 10.5 PGR TP53
47 malignant thyroid stimulating hormone producing neoplasm of pituitary gland 10.5 ERBB2 ESR1 PGR
48 comedo carcinoma 10.5 ERBB2 ESR1 PGR
49 anal paget's disease 10.5 ERBB2 ESR1 PGR
50 fallopian tube papillary adenocarcinoma 10.5 ERBB2 ESR1 PGR

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer

Symptoms & Phenotypes for Sporadic Breast Cancer

GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.7 BARD1 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.7 BRCA1 RAD51
3 Decreased homologous recombination repair frequency GR00236-A-1 10.7 BARD1 BRCA1 BRCA2 PGR RAD51
4 Decreased homologous recombination repair frequency GR00236-A-2 10.7 ATM BARD1 BRCA1 BRCA2 PGR RAD51
5 Decreased homologous recombination repair frequency GR00236-A-3 10.7 BARD1 BRCA1 BRCA2 RAD51
6 Decreased ionizing radiation sensitivity GR00232-A-1 10.01 BRCA1 BRCA2 ESR2 FANCD2 PGR TTC4
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 CHEK2 TP53 FANCD2 XRCC1 PTEN ATM
8 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 FANCD2 XRCC1 PTEN RAD51 TP53 ATM
9 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.81 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
10 Increased cell death HMECs cells GR00103-A-0 9.73 BRCA1 PGR PTEN RAD51 TP53 TTC4
11 Decreased viability with cisplatin GR00101-A-4 9.62 BARD1 BRCA1 BRCA2 RAD51
12 Decreased viability after ionizing radiation GR00232-A-2 9.54 ATM BRCA1 BRCA2
13 Synthetic lethal with cisplatin GR00101-A-1 9.26 BARD1 BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
2 behavior/neurological MP:0005386 10.31 PTEN TP53 XRCC1 ATM BRCA1 BRCA2
3 growth/size/body region MP:0005378 10.29 PTEN RAD51 TP53 XRCC1 ATM BARD1
4 homeostasis/metabolism MP:0005376 10.29 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
5 embryo MP:0005380 10.28 ERBB2 ESR1 PGR PTEN RAD51 TP53
6 endocrine/exocrine gland MP:0005379 10.26 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
7 hematopoietic system MP:0005397 10.24 ATM BRCA1 BRCA2 CHEK2 ESR1 ESR2
8 mortality/aging MP:0010768 10.24 FANCD2 FHIT PGR PTEN RAD51 TP53
9 immune system MP:0005387 10.2 BRCA2 CHEK2 ESR1 ESR2 FANCD2 FHIT
10 digestive/alimentary MP:0005381 10.15 BRCA1 BRCA2 ERBB2 ESR1 ESR2 FHIT
11 integument MP:0010771 10.13 PGR PTEN TP53 ATM BRCA1 BRCA2
12 neoplasm MP:0002006 10.1 BRCA2 CHEK2 ERBB2 ESR1 ESR2 FANCD2
13 limbs/digits/tail MP:0005371 10.06 BRCA1 BRCA2 ERBB2 ESR1 ESR2 FANCD2
14 adipose tissue MP:0005375 10.05 ATM BRCA1 ESR1 ESR2 PTEN TP53
15 nervous system MP:0003631 9.93 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
16 muscle MP:0005369 9.87 BRCA1 ERBB2 ESR1 ESR2 PGR PTEN
17 normal MP:0002873 9.65 BARD1 BRCA1 BRCA2 ERBB2 ESR1 ESR2
18 reproductive system MP:0005389 9.32 ESR1 ESR2 ATM BRCA1 BRCA2 ERBB2

Drugs & Therapeutics for Sporadic Breast Cancer

Drugs for Sporadic Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
3
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
4
Povidone Approved Phase 2 9003-39-8
5 Albumin-Bound Paclitaxel Phase 2
6 Analgesics Phase 2
7 Anti-Anxiety Agents Phase 2
8 Anticonvulsants Phase 2
9 Antimitotic Agents Phase 2
10 Antineoplastic Agents, Phytogenic Phase 2
11 calcium channel blockers Phase 2
12 Calcium, Dietary Phase 2
13 Central Nervous System Depressants Phase 2
14 Peripheral Nervous System Agents Phase 2
15 Psychotropic Drugs Phase 2
16 Tranquilizing Agents Phase 2
17 Analgesics, Non-Narcotic Phase 2
18 Anti-Inflammatory Agents Phase 2
19 Anti-Inflammatory Agents, Non-Steroidal Phase 2
20 Antirheumatic Agents Phase 2
21 Carboxymethylcellulose Sodium Phase 2
22 Cyclooxygenase 2 Inhibitors Phase 2
23 Cyclooxygenase Inhibitors Phase 2
24
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
25
Olaparib Approved Phase 1 763113-22-0 23725625
26 Poly(ADP-ribose) Polymerase Inhibitors Phase 1
27 Hypoglycemic Agents
28 insulin
29 Insulin, Globin Zinc

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia Unknown status NCT02024568 Phase 2 Pregabalin;Placebo
2 A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer Completed NCT00600275 Phase 1, Phase 2 BGT226
3 Celecoxib Window of Opportunity Trial to Assess Tumor and Stroma Responses Not yet recruiting NCT03185871 Phase 2 Celecoxib
4 AZD2281 Plus Carboplatin to Treat Breast and Ovarian Cancer Active, not recruiting NCT01445418 Phase 1 AZ2281 + Carboplatin
5 Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer Unknown status NCT01172886
6 Insulin Resistance and Breast Cancer Completed NCT00304941
7 Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation Recruiting NCT02664389
8 Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers Active, not recruiting NCT02087592

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

MalaCards organs/tissues related to Sporadic Breast Cancer:

39
Breast, Endothelial

Publications for Sporadic Breast Cancer

Articles related to Sporadic Breast Cancer:

(show top 50) (show all 280)
id Title Authors Year
1
Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. ( 28190851 )
2017
2
TGFbeta and miRNA regulation in familial and sporadic breast cancer. ( 28881597 )
2017
3
Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53. ( 28630214 )
2017
4
Simultaneous ATM/BRCA1/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients. ( 28058614 )
2017
5
Variants of estrogen receptor alpha and beta genes modify the severity of sporadic breast cancer. ( 28109853 )
2017
6
Can MTHFR C677T and A1298C Polymorphisms Alter the Risk and Severity of Sporadic Breast Cancer in Brazilian Women? ( 28330681 )
2017
7
Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers. ( 27837030 )
2017
8
Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients. ( 26205471 )
2016
9
Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards. ( 27189832 )
2016
10
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility. ( 26650628 )
2016
11
Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer. ( 26723934 )
2016
12
A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility. ( 27668787 )
2016
13
Twenty-one-gene recurrence score assay in BRCA-associated versus sporadic breast cancers: Differences based on germline mutation status. ( 26859126 )
2016
14
Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. ( 27413552 )
2016
15
RECQL4 helicase has oncogenic potential in sporadic breast cancers. ( 26690729 )
2016
16
Association between genetic variants of EGF-containing fibulin-like extracellular matrix protein1 gene and sporadic breast cancer in a Chinese Han population. ( 27048115 )
2016
17
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. ( 26754093 )
2016
18
Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1. ( 27039925 )
2016
19
Assessing Heavy Metal and PCB Exposure from Tap Water by Measuring Levels in Plasma from Sporadic Breast Cancer Patients, a Pilot Study. ( 26690196 )
2015
20
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer. ( 26430163 )
2015
21
Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study. ( 26476291 )
2015
22
DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China. ( 25961110 )
2015
23
Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China. ( 26535628 )
2015
24
Decreased Expression of BRCA2 Accelerates Sporadic Breast Cancer Progression. ( 27065665 )
2015
25
Development and validation of molecular methodologies to assess PALB2 expression in sporadic breast cancer. ( 26526077 )
2015
26
ATM gene mutations in sporadic breast cancer patients from Brazil. ( 25625042 )
2015
27
Promoter methylation and expression changes of BRCA1 in cancerous tissues of patients with sporadic breast cancer. ( 25789047 )
2015
28
First description of a sporadic breast cancer in a woman with BRCA1 germline mutation. ( 26426992 )
2015
29
Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies. ( 26643130 )
2015
30
Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. ( 26456802 )
2015
31
The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population. ( 25674498 )
2015
32
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women. ( 26598080 )
2015
33
A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer. ( 26320393 )
2015
34
The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer. ( 24842653 )
2014
35
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis. ( 24464625 )
2014
36
The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients. ( 24850984 )
2014
37
Association of TNF-I+, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women. ( 25010932 )
2014
38
Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers. ( 25342642 )
2014
39
Association of +405C>G and +936C>T polymorphisms of the vascular endothelial growth factor gene with sporadic breast cancer in North Indians. ( 24528036 )
2014
40
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts. ( 25425972 )
2014
41
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. ( 24556691 )
2014
42
BRCA1 gene exon 11 mutations in Uighur and Han women with early-onset sporadic breast cancer in the northwest region of China. ( 24969878 )
2014
43
Combined microRNA and ER expression: a new classifier for familial and sporadic breast cancer patients. ( 25406994 )
2014
44
Association of promoter methylation of ERI+ and ERI^ with sporadic breast cancer--a study from North India. ( 24833090 )
2014
45
A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. ( 25067956 )
2014
46
Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. ( 23063927 )
2013
47
HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women. ( 23976978 )
2013
48
Potential clinical significance of ERI^ ON promoter methylation in sporadic breast cancer. ( 23794253 )
2013
49
Loss of WIF-1 and Wnt5a expression is related to aggressiveness of sporadic breast cancer in Tunisian patients. ( 23417837 )
2013
50
MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. ( 23860775 )
2013

Variations for Sporadic Breast Cancer

Expression for Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for Sporadic Breast Cancer

Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 48)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 ATM BRCA1 CHEK2 ERBB2 ESR1 ESR2
2
Show member pathways
13.78 ATM BARD1 BRCA1 CHEK2 ERBB2 ESR1
3
Show member pathways
13.4 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
13.18 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
5
Show member pathways
12.95 ATM BARD1 BRCA1 CHEK2 FANCD2 PTEN
6
Show member pathways
12.89 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
7
Show member pathways
12.8 BARD1 BRCA1 ESR1 PTEN TP53
8 12.66 BRCA2 ERBB2 PTEN RAD51 TP53
9
Show member pathways
12.63 ATM BARD1 BRCA1 CHEK2 TP53
10 12.51 ATM BRCA1 ERBB2 PTEN TP53
11
Show member pathways
12.51 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
12 12.5 ATM BRCA1 BRCA2 CHEK2 RAD51 TP53
13
Show member pathways
12.47 ATM BRCA1 BRCA2 RAD51
14
Show member pathways
12.45 ERBB2 ESR1 ESR2 PTEN
15
Show member pathways
12.41 ATM CHEK2 ERBB2 TP53
16
Show member pathways
12.38 ATM BRCA1 CHEK2 FANCD2 PTEN RAD51
17
Show member pathways
12.36 ATM BARD1 BRCA1 CHEK2 TP53
18
Show member pathways
12.27 ATM BARD1 BRCA1 BRCA2 RAD51
19
Show member pathways
12.23 ATM BRCA1 CHEK2 PTEN TP53
20
Show member pathways
12.21 BRCA1 CHEK2 ESR1 PGR
21
Show member pathways
12.13 ATM BARD1 BRCA1 BRCA2 RAD51
22 12.07 ATM CHEK2 PTEN TP53
23 12 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
24 11.98 ATM ERBB2 PTEN TP53
25
Show member pathways
11.97 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
26
Show member pathways
11.91 ERBB2 ESR1 PGR
27 11.89 BRCA1 BRCA2 FANCD2 RAD51
28
Show member pathways
11.85 ATM BRCA1 CHEK2 FANCD2 RAD51 TP53
29
Show member pathways
11.82 ESR1 ESR2 PGR
30 11.79 FHIT PTEN TP53
31 11.73 ATM BRCA1 ERBB2 TP53
32 11.72 ATM BRCA1 XRCC1
33
Show member pathways
11.72 ATM CHEK2 TP53
34 11.7 ATM BRCA1 CHEK2 ERBB2 PTEN TP53
35 11.66 ERBB2 PTEN TP53
36 11.62 ATM CHEK2 TP53
37 11.51 ATM BARD1 BRCA1 CHEK2 PTEN TP53
38
Show member pathways
11.48 ATM CHEK2 TP53
39
Show member pathways
11.48 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
40 11.44 ATM BARD1 BRCA1 CHEK2 FANCD2 TP53
41 11.41 BRCA2 CHEK2 ESR1 XRCC1
42 11.39 ESR1 PTEN TP53
43 11.31 ATM BRCA1 TP53
44 11.3 ATM ESR2 PGR
45 11.2 ATM BARD1 BRCA1 FANCD2 RAD51 TP53
46 11.05 ATM BRCA1 TP53
47 10.35 CHEK2 TP53
48 10.25 ESR1 ESR2

GO Terms for Sporadic Breast Cancer

Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
2 nuclear chromosome, telomeric region GO:0000784 9.71 ATM BRCA2 RAD51 XRCC1
3 nuclear chromatin GO:0000790 9.63 ESR1 RAD51 TP53
4 PML body GO:0016605 9.56 CHEK2 PTEN RAD51 TP53
5 condensed chromosome GO:0000793 9.54 BRCA1 FANCD2 RAD51
6 nucleoplasm GO:0005654 9.47 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
7 BRCA1-A complex GO:0070531 9.43 BARD1 BRCA1
8 lateral element GO:0000800 9.33 BRCA1 BRCA2 RAD51
9 BRCA1-BARD1 complex GO:0031436 9.32 BARD1 BRCA1

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 33)
id Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.97 ATM BRCA1 CHEK2 ESR1 TP53
2 protein deubiquitination GO:0016579 9.97 BARD1 BRCA1 ESR1 PTEN TP53
3 regulation of signal transduction by p53 class mediator GO:1901796 9.85 ATM BARD1 BRCA1 CHEK2 TP53
4 DNA recombination GO:0006310 9.83 BRCA1 BRCA2 RAD51
5 double-strand break repair via nonhomologous end joining GO:0006303 9.81 ATM BARD1 BRCA1 XRCC1
6 double-strand break repair GO:0006302 9.8 BRCA1 BRCA2 CHEK2
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.8 ATM CHEK2 TP53
8 steroid hormone mediated signaling pathway GO:0043401 9.79 ESR1 ESR2 PGR
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.78 ATM BRCA1 BRCA2 CHEK2
10 double-strand break repair via homologous recombination GO:0000724 9.77 ATM BRCA1 BRCA2 RAD51 XRCC1
11 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.73 BRCA2 CHEK2 TP53
12 response to gamma radiation GO:0010332 9.73 BRCA2 CHEK2 FANCD2 TP53
13 response to X-ray GO:0010165 9.71 BRCA2 RAD51 TP53
14 cellular response to gamma radiation GO:0071480 9.71 ATM CHEK2 RAD51 TP53
15 DNA double-strand break processing GO:0000729 9.7 ATM BARD1 BRCA1
16 replicative senescence GO:0090399 9.67 ATM CHEK2 TP53
17 determination of adult lifespan GO:0008340 9.65 ATM TP53
18 DNA synthesis involved in DNA repair GO:0000731 9.65 ATM BARD1 BRCA1 BRCA2 RAD51
19 telomere maintenance via recombination GO:0000722 9.64 BRCA2 RAD51
20 DNA damage induced protein phosphorylation GO:0006975 9.64 ATM CHEK2
21 protein K6-linked ubiquitination GO:0085020 9.63 BARD1 BRCA1
22 chromosome organization involved in meiotic cell cycle GO:0070192 9.62 ATM RAD51
23 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.62 BRCA1 BRCA2 CHEK2 TP53
24 DNA repair GO:0006281 9.61 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
25 chordate embryonic development GO:0043009 9.59 BRCA1 BRCA2
26 mitotic recombination-dependent replication fork processing GO:1990426 9.55 BRCA2 RAD51
27 strand displacement GO:0000732 9.55 ATM BARD1 BRCA1 BRCA2 RAD51
28 cellular response to DNA damage stimulus GO:0006974 9.32 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
29 regulation of transcription, DNA-templated GO:0006355 10.31 BRCA1 CHEK2 EMSY ERBB2 ESR1 ESR2
30 transcription, DNA-templated GO:0006351 10.3 BRCA1 CHEK2 EMSY ERBB2 ESR1 ESR2
31 apoptotic process GO:0006915 10.08 ATM BRCA1 CHEK2 FHIT PTEN TP53
32 cell cycle GO:0007049 10.08 ATM BRCA1 BRCA2 CHEK2 FANCD2 TP53
33 positive regulation of transcription, DNA-templated GO:0045893 10.06 BRCA1 BRCA2 CHEK2 ESR1 ESR2 TP53

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.88 ATM CHEK2 ERBB2 FHIT RAD51
2 identical protein binding GO:0042802 9.87 CHEK2 ERBB2 ESR1 FHIT PTEN RAD51
3 ubiquitin protein ligase binding GO:0031625 9.85 BRCA1 CHEK2 FHIT TP53
4 lipid binding GO:0008289 9.83 ESR1 ESR2 PGR PTEN
5 damaged DNA binding GO:0003684 9.69 BRCA1 TP53 XRCC1
6 steroid hormone receptor activity GO:0003707 9.67 ESR1 ESR2 PGR
7 core promoter sequence-specific DNA binding GO:0001046 9.61 ESR1 ESR2 TP53
8 DNA polymerase binding GO:0070182 9.54 FANCD2 RAD51
9 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.54 ESR1 ESR2 PGR
10 estrogen receptor activity GO:0030284 9.46 ESR1 ESR2
11 estrogen response element binding GO:0034056 9.4 ESR1 ESR2
12 steroid binding GO:0005496 9.33 ESR1 ESR2 PGR
13 enzyme binding GO:0019899 9.17 BRCA1 ESR1 ESR2 PGR PTEN TP53
14 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
15 protein binding GO:0005515 10.19 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY

Sources for Sporadic Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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