MCID: SPR009
MIFTS: 46

Sporadic Breast Cancer malady

Categories: Genetic diseases, Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Sporadic Breast Cancer

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Aliases & Descriptions for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 10 12
 
Sporadic Breast Carcinoma 65

Classifications:



External Ids:

Disease Ontology10 DOID:8029
NCIt42 C7566
UMLS65 C1336076

Summaries for Sporadic Breast Cancer

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MalaCards based summary: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to urethritis and lymphoepithelioma-like carcinoma. An important gene associated with Sporadic Breast Cancer is TTC4 (Tetratricopeptide Repeat Domain 4), and among its related pathways are PLK3 signaling events and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include breast, brain and endothelial, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Related Diseases for Sporadic Breast Cancer

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Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
sporadic breast cancer Breast Carcinoma in Situ
Familial Breast Cancer Bard1-Related Susceptibility to Breast Cancer
Brip1-Related Breast Cancer Chek2-Related Susceptibility to Breast Cancer
Rad51-Related Susceptibility to Breast Cancer

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1urethritis30.3BRCA2, FANCD2, RAD51
2lymphoepithelioma-like carcinoma30.1ERBB2, ESR1, PGR
3prostate cancer28.2ATM, BRCA1, BRCA2, CHEK2, ERBB2, ESR1
4breast cancer27.8ATM, BARD1, BRCA1, BRCA2, CHEK2, EMSY
5lung cancer27.8ATM, ERBB2, ESR2, GSTM1, GSTT1, PTEN
6congenital pulmonary veins atresia or stenosis10.6BRCA1, BRCA2
7bronchiolitis obliterans10.5BRCA1, BRCA2
8pancreatic cancer 410.5BRCA1, BRCA2
9syringoma10.5ESR1, PGR
10endocrine organ benign neoplasm10.5ESR1, PGR
11cervical benign neoplasm10.5ESR1, PGR
12large bowel leiomyoma10.5ESR1, PGR
13bile duct cystadenoma10.5ESR1, PGR
14kidney leiomyosarcoma10.5ESR1, TP53
15metachronous kidney wilms' tumor10.5PGR, TP53
16venous tributary occlusion of retina10.5ESR1, PGR
17liddle syndrome, scnn1b-related10.5CHEK2, TP53
18deep leiomyoma10.4PGR, TP53
19peroneal nerve paralysis10.4ESR1, PGR
20autoimmune disease of urogenital tract10.4BRCA1, BRCA2, PGR
21malignant testicular leydig cell tumor10.4BRCA1, BRCA2, PGR
22tetrasomy 2110.4BRCA1, BRCA2, TP53
23spinal meninges cancer10.4BRCA2, ESR1, ESR2
24vulvar squamous papilloma10.4ESR1, PGR
25intraductal papilloma10.4PGR, PTEN
26kidney benign neoplasm10.4BRCA1, ESR2, TP53
27mastitis10.4BRCA1, BRCA2
28common bile duct disease10.4ATM, BRCA1, TP53
29small intestine leiomyosarcoma10.4ESR1, ESR2, TP53
30deafness, autosomal dominant 8/1210.4ESR1, ESR2, PGR
31breast sarcoma10.4ESR1, TP53
32extragonadal nonseminomatous germ cell tumor10.4ESR1, PGR
33retroperitoneal sarcoma10.4ESR1, ESR2, PGR
34sciatic neuropathy10.4ESR1, ESR2, PGR
35intraventricular meningioma10.4ESR1, ESR2, PGR
36uterine corpus adenosarcoma10.4ESR1, PGR, TP53
37renal pelvis squamous cell carcinoma10.4ESR1, PGR, TP53
38endotheliitis10.3
39lymphadenitis10.3ESR1, ESR2, PGR
40pituitary gland disease10.3ERBB2, ESR1
41esophageal adenoid cystic carcinoma10.3ESR1, PGR
42photosensitive epilepsy10.3ESR1, ESR2, PGR
43leptospirosis10.3ESR1, ESR2, PGR
44male reproductive organ benign neoplasm10.3ESR1, PGR, TP53
45blepharochalasis10.3ESR1, ESR2, TP53
46oculoglandular tularemia10.3ESR1, ESR2, PGR
47disease of mental health10.3ESR1, ESR2, PGR
48vulval paget's disease10.3ESR1, TP53
49adenofibroma10.3ERBB2, PGR
50autoimmune polyendocrine syndrome type 110.3BRCA1, BRCA2, ERBB2

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to sporadic breast cancer

Symptoms for Sporadic Breast Cancer

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Drugs & Therapeutics for Sporadic Breast Cancer

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Drugs for Sporadic Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PaclitaxelapprovedPhase 2262133069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
2
Pregabalinapproved, illicit, investigationalPhase 2340148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
3Peripheral Nervous System AgentsPhase 218510
4Albumin-Bound PaclitaxelPhase 22621
5Anti-Anxiety AgentsPhase 21529
6Tranquilizing AgentsPhase 23597
7AnalgesicsPhase 29358
8Psychotropic DrugsPhase 25501
9AnticonvulsantsPhase 22249
10calcium channel blockersPhase 21743
11Calcium, DietaryPhase 24678
12Central Nervous System DepressantsPhase 210016
13
OlaparibapprovedPhase 1104763113-22-023725625
Synonyms:
4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one
4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one
4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
763113-22-0
937799-91-2
AKOS005145764
AZD 2281
AZD-2281
AZD2281
 
Acylpiperazine analogue, 47
CHEMBL521686
EC-000.2324
EN002690
FT-0083489
KU-0059436
KU-59436
Olaparib
Olaparib, KU-0059436, AZD2281, KU0059436, AZD2281
S1060_Selleck
olaparib
14
CarboplatinapprovedPhase 1188541575-94-410339178, 498142, 38904
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)
15Poly(ADP-ribose) Polymerase InhibitorsPhase 1250
16
Lapatinibapproved, investigational, Approved March 2007Phase 0294231277-92-2, 388082-78-8208908, 9941095
Synonyms:
1xkk
231277-92-2
388082-78-8
4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
AB1004631
AC-1314
AC1L4LL4
AKOS005145766
CHEBI:49603
CHEMBL1201179
CHEMBL554
CID11557040
CID208908
D04024
D08108
DB01259
DB02584
EN002712
FMM
GSK 572016
GSK572016
GW 572016
GW 572016X
GW-2016
GW-572016
GW-572016F
GW2016
GW572016
HMS2089H10
I01-1247
 
Kinome_3684
Kinome_3685
LAPATINIB DITOSYLATE MONOHYDRATE
LS-187029
LS-187771
Lapatinib
Lapatinib (INN)
Lapatinib Ditosylate
Lapatinib [INN]
Lapatinib ditosylate
Lapatinib ditosylate (USAN)
Lapatinib tosilate hydrate
Lapatinib tosilate hydrate (JAN)
Lapatinib, Tykerb, GW572016
N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine
N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
NCGC00167507-01
NSC745750
TL80090051
Tycerb
Tykerb
Tykerb (TN)
Tyverb
UNII-0VUA21238F
lapatinib
lapatinib ditosylate
nchembio866-comp20
17insulin4278
18Insulin, Globin Zinc4278
19Protein Kinase InhibitorsPhase 03162

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast CancerCompletedNCT00600275Phase 1, Phase 2
2Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-MyalgiaNot yet recruitingNCT02024568Phase 2
3AZD2281 Plus Carboplatin to Treat Breast and Ovarian CancerActive, not recruitingNCT01445418Phase 1
4Insulin Resistance and Breast CancerCompletedNCT00304941
5Metabolic Syndrome as Modifiable Risk Factor for Breast CancerRecruitingNCT01172886
6Concentration and Activity of Lapatinib in Vestibular SchwannomasRecruitingNCT00863122Phase 0
7Feasibility of Lifestyle Intervention in BRCA1/2 Mutation CarriersActive, not recruitingNCT02087592
8Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary PresentationNot yet recruitingNCT02664389

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

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Anatomical Context for Sporadic Breast Cancer

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MalaCards organs/tissues related to Sporadic Breast Cancer:

33
Breast, Brain, Endothelial, Bone, Prostate, Myeloid, T cells

Animal Models for Sporadic Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Sporadic Breast Cancer:

38 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0ATM, BRCA1, ESR1, ESR2, PTEN, TP53
2MP:00053818.8BRCA1, BRCA2, ERBB2, ESR1, ESR2, PTEN
3MP:00053698.7BRCA1, ERBB2, ESR1, ESR2, PGR, PTEN
4MP:00107718.4ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
5MP:00053908.2BRCA1, BRCA2, ERBB2, ESR1, ESR2, PGR
6MP:00053718.0BRCA1, BRCA2, ERBB2, ESR1, ESR2, FANCD2
7MP:00053797.8ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
8MP:00053897.7ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
9MP:00028737.7BARD1, BRCA1, BRCA2, ERBB2, ESR1, ESR2
10MP:00053807.6ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
11MP:00053877.4ATM, BRCA1, BRCA2, CHEK2, ESR1, ESR2
12MP:00053977.4ATM, BRCA1, BRCA2, CHEK2, ESR1, ESR2
13MP:00053867.1ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
14MP:00036317.0ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
15MP:00053766.7ATM, BRCA1, BRCA2, CHEK2, ERBB2, ESR1
16MP:00053786.5ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
17MP:00020066.5ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
18MP:00053846.0ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
19MP:00107686.0ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2

Publications for Sporadic Breast Cancer

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Articles related to Sporadic Breast Cancer:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis. (25533300)
2015
2
Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects. (24492466)
2014
3
Sensitivity, positive predictive value, and interobserver variability of computed tomography in the diagnosis of bullae associated with spontaneous pneumothorax in dogs: 19 cases (2003-2012). (23822082)
2013
4
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. (24113189)
2013
5
Molecular genetic analysis of a patient with moderate hemophilia A and psychomotor developmental delay. (23709133)
2013
6
Effect of hippotherapy on motor control, adaptive behaviors, and participation in children with autism spectrum disorder: a pilot study. (24195899)
2013
7
Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. (22340480)
2012
8
Pharmacogenetic analysis of BR.21, a placebo-controlled randomized phase III clinical trial of erlotinib in advanced non-small cell lung cancer. (22237259)
2012
9
Spontaneous regression of intraocular lymphoma. (22551603)
2012
10
Fexofenadine-induced urticaria. (22346270)
2011
11
A novel role for IL-22R1 as a driver of inflammation. (20971950)
2011
12
Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency. (21310276)
2011
13
Suppression of vascular endothelial growth factor receptor 3 (VEGFR3) and vascular endothelial growth factor C (VEGFC) inhibits hypoxia-induced lymph node metastases in cervix cancer. (21839498)
2011
14
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
15
Five polymorphisms of vascular endothelial growth factor (VEGF) and risk of breast cancer: a meta-analysis involving 16,703 individuals. (21798757)
2011
16
Evaluation of a metofluthrin fan vaporizer device against phlebotomine sand flies (Diptera: Psychodidae) in a cutaneous leishmaniasis focus in the Judean Desert, Israel. (21366769)
2011
17
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Variations for Sporadic Breast Cancer

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Expression for genes affiliated with Sporadic Breast Cancer

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Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for genes affiliated with Sporadic Breast Cancer

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Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 43)
idSuper pathwaysScoreTop Affiliating Genes
19.9CHEK2, TP53
29.9ESR1, ESR2
39.7ATM, BRCA1, TP53
49.7ATM, BRCA1, TP53
59.7ATM, BRCA2, RAD51
6
Show member pathways
9.6ESR1, ESR2, PGR
7
Show member pathways
9.6ESR1, ESR2, PGR
8
Show member pathways
9.6ATM, CHEK2, TP53
9
Show member pathways
9.6ATM, CHEK2, TP53
109.6ATM, ESR2, PGR
119.5ATM, BRCA1, XRCC1
12
Show member pathways
9.5ATM, BRCA1, BRCA2, RAD51
13
Show member pathways
9.4BRCA1, CHEK2, ESR1, PGR
149.4ERBB2, PTEN, TP53
15
Show member pathways
9.4BRCA2, ERBB2, RAD51, TP53
16
Show member pathways
9.3ATM, CHEK2, ERBB2, TP53
17
Show member pathways
9.2ATM, CHEK2, ERBB2, TP53
189.2BRCA2, CHEK2, ESR1, XRCC1
19
Show member pathways
9.2BRCA2, CHEK2, ESR1, XRCC1
20
Show member pathways
9.1BRCA1, BRCA2, FANCD2, RAD51
21
Show member pathways
9.1ATM, BARD1, BRCA1, BRCA2, RAD51
22
Show member pathways
9.1ATM, BARD1, BRCA1, BRCA2, RAD51
23
Show member pathways
9.0ATM, BARD1, BRCA1, CHEK2, TP53
24
Show member pathways
9.0ATM, BARD1, BRCA1, CHEK2, TP53
259.0ATM, BRCA1, ERBB2, PTEN, TP53
26
Show member pathways
8.9ATM, BRCA1, CHEK2, PTEN, TP53
278.9BRCA2, ERBB2, PTEN, RAD51, TP53
28
Show member pathways
8.7ATM, BRCA1, BRCA2, ERBB2, PTEN, TP53
29
Show member pathways
8.5ATM, BARD1, BRCA1, CHEK2, PTEN, TP53
30
Show member pathways
8.5ATM, BRCA1, CHEK2, FANCD2, RAD51, TP53
31
Show member pathways
8.5ATM, BARD1, BRCA1, BRCA2, CHEK2, RAD51
328.4ATM, BARD1, BRCA1, FANCD2, RAD51, TP53
338.4ATM, BARD1, BRCA1, CHEK2, FANCD2, TP53
34
Show member pathways
8.0ATM, BRCA1, CHEK2, FANCD2, PTEN, RAD51
35
Show member pathways
7.9ATM, BARD1, BRCA1, CHEK2, FANCD2, PTEN
367.8ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
37
Show member pathways
7.8ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
387.8ATM, BARD1, BRCA1, BRCA2, CHEK2, ESR1
397.5ATM, BRCA1, BRCA2, CHEK2, ERBB2, ESR1
40
Show member pathways
7.3ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
41
Show member pathways
7.1ATM, BRCA1, CHEK2, ERBB2, ESR1, ESR2
42
Show member pathways
7.1ATM, BARD1, BRCA1, CHEK2, ESR1, ESR2
43
Show member pathways
6.7ATM, BARD1, BRCA1, BRCA2, CHEK2, ESR1

GO Terms for genes affiliated with Sporadic Breast Cancer

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Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:00166059.1CHEK2, PTEN, RAD51, TP53

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1Sertoli cell developmentGO:006000910.6ESR1, ESR2
2determination of adult lifespanGO:000834010.5ATM, TP53
3Sertoli cell proliferationGO:006001110.5ESR1, ESR2
4regulation of neuron apoptotic processGO:004352310.5ESR1, ESR2
5protein K6-linked ubiquitinationGO:008502010.4BARD1, BRCA1
6DNA damage induced protein phosphorylationGO:000697510.4ATM, CHEK2
7cellular response to gamma radiationGO:007148010.3ATM, RAD51
8chordate embryonic developmentGO:004300910.3BRCA1, BRCA2
9DNA synthesis involved in DNA repairGO:000073110.1ATM, BRCA1, BRCA2
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1BRCA1, BRCA2, TP53
11DNA double-strand break processingGO:000072910.0ATM, BARD1, BRCA1
12double-strand break repairGO:00063029.9ATM, BARD1, TP53
13response to gamma radiationGO:00103329.9BRCA2, CHEK2, TP53
14regulation of signal transduction by p53 class mediatorGO:19017969.9ATM, BARD1, CHEK2
15strand displacementGO:00007329.9ATM, BARD1, BRCA2
16intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.8ATM, BRCA1, BRCA2, CHEK2
17positive regulation of ERK1 and ERK2 cascadeGO:00703749.6ESR1, ESR2, PTEN
18positive regulation of transcription, DNA-templatedGO:00458939.4BRCA2, CHEK2, ESR1, ESR2, TP53
19double-strand break repair via synthesis-dependent strand annealingGO:00450039.4ATM, BARD1, BRCA1, BRCA2, RAD51
20transcription initiation from RNA polymerase II promoterGO:00063679.3ESR1, ESR2, PGR, PTEN
21replicative senescenceGO:00903999.3ATM, CHEK2, TP53
22gene expressionGO:00104679.3ESR1, PGR, PTEN, TP53
23double-strand break repair via homologous recombinationGO:00007248.9ATM, BARD1, BRCA1, BRCA2, RAD51, XRCC1
24cellular response to DNA damage stimulusGO:00069748.4ATM, BRCA1, BRCA2, CHEK2, RAD51, TP53

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1core promoter sequence-specific DNA bindingGO:00010469.9ESR1, ESR2

Sources for Sporadic Breast Cancer

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet