MCID: SPR009
MIFTS: 46

Sporadic Breast Cancer malady

Categories: Genetic diseases, Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Sporadic Breast Cancer

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Aliases & Descriptions for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 11 13
 
Sporadic Breast Carcinoma 66

Classifications:



External Ids:

Disease Ontology11 DOID:8029
NCIt43 C7566

Summaries for Sporadic Breast Cancer

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MalaCards based summary: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to familial breast cancer and breast cancer. An important gene associated with Sporadic Breast Cancer is TTC4 (Tetratricopeptide Repeat Domain 4), and among its related pathways are PLK3 signaling events and DNA Damage Induced 14-3-3Sigma Signaling. Affiliated tissues include breast and endothelial, and related mouse phenotypes are adipose tissue and muscle.

Related Diseases for Sporadic Breast Cancer

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Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
sporadic breast cancer Breast Carcinoma in Situ
Familial Breast Cancer Bard1-Related Susceptibility to Breast Cancer
Brip1-Related Breast Cancer Chek2-Related Susceptibility to Breast Cancer
Rad51-Related Susceptibility to Breast Cancer

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1familial breast cancer30.4BRCA1, BRCA2, CHEK2
2breast cancer25.8ATM, BARD1, BRCA1, BRCA2, CHEK2, EMSY
3congenital pulmonary veins atresia or stenosis10.9BRCA1, BRCA2
4bronchopulmonary dysplasia10.8BRCA1, BRCA2
5vulvar angiokeratoma10.7ESR1, PGR
6central nervous system organ benign neoplasm10.7ESR1, PGR
7fallopian tube benign neoplasm10.7ESR1, PGR
8appendix leiomyoma10.7ESR1, PGR
9lethal congenital contracture syndrome 710.7BRCA1, BRCA2
10mixed cell adenoma10.7ESR1, PGR
11mixed cell type kidney wilms' tumor10.7PGR, TP53
12tuberous sclerosis10.7ESR1, PGR
13papillary adenofibroma10.7BRCA1, BRCA2, TP53
14liddle syndrome, scnn1g-related10.6CHEK2, TP53
15autoimmune disease of blood10.6BRCA1, BRCA2, PGR
16selective ige deficiency disease10.6BRCA1, BRCA2, PGR
17dental enamel hypoplasia10.6ESR1, PGR
18breast squamous cell carcinoma10.6BRCA1, BRCA2, PGR
19mediastinal neurilemmoma10.6BRCA1, BRCA2, PGR
20perinatal intestinal perforation10.6ESR1, PGR
21uterine body mixed cancer10.6ESR1, PGR, TP53
22bile duct disease10.6ATM, BRCA1, TP53
23deafness, autosomal dominant 8/1210.6ESR1, ESR2, PGR
24retroperitoneum carcinoma10.5ESR1, ESR2, PGR
25allergic cutaneous vasculitis10.5ESR1, ESR2, PGR
26epithelioid type angiomyolipoma10.5ESR1, PGR, TP53
27breast cancer, childhood10.5BRCA1, BRCA2, CHEK2
28bartholin's gland adenoid cystic carcinoma10.5ESR1, PGR
29simple partial epilepsy10.5PGR, TP53
30eyelid disease10.5ERBB2, ESR1
31fallopian tube adenosarcoma10.5ESR1, PGR, TP53
32lateral sclerosis10.5ESR1, ESR2, PGR
33papillary carcinoma10.5ESR2, PGR, TP53
34botulism10.5ESR1, ESR2
35levic stefanovic nikolic syndrome10.5GSTM1, TP53, XRCC1
36frontal sinus inverted papilloma10.4PGR, TP53
37fallopian tube germ cell cancer10.4BRCA1, BRCA2, ESR1, PGR
38candidiasis10.4ESR1, ESR2, PGR
39myopathy10.4ESR1, PGR, TP53
40fat necrosis of breast10.4BRCA1, BRCA2
41cystinosis, nephropathic10.4ERBB2, TP53
42cutaneous lupus erythematosus10.4BRCA1, BRCA2, ERBB2
43ovarian brenner tumor10.4BRCA1, BRCA2, PGR, TP53
44oral lichen planus10.4GSTM1, TP53, XRCC1
45asthma susceptibility 510.4ESR1, PGR
46ovarian cancer, somatic10.4BRCA1, BRCA2, ERBB2
47ossifying fibromyxoid tumor10.4ERBB2, PGR
48breast myofibroblastoma10.4PGR, PTEN
49cutaneous mucoepidermoid carcinoma10.4ERBB2, PGR
50gastrointestinal system cancer10.3BRCA1, ESR2, PGR, TP53

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to sporadic breast cancer

Symptoms for Sporadic Breast Cancer

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Drugs & Therapeutics for Sporadic Breast Cancer

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Drugs for Sporadic Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1calcium channel blockersPhase 21889
2
PregabalinPhase 2348148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
3
PaclitaxelPhase 2269133069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
4
OlaparibPhase 1117763113-22-023725625
Synonyms:
4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one
4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one
4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
763113-22-0
937799-91-2
AKOS005145764
AZD 2281
AZD-2281
AZD2281
 
Acylpiperazine analogue, 47
CHEMBL521686
EC-000.2324
EN002690
FT-0083489
KU-0059436
KU-59436
Olaparib
Olaparib, KU-0059436, AZD2281, KU0059436, AZD2281
S1060_Selleck
olaparib
5
CarboplatinPhase 1194241575-94-410339178, 498142, 38904
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)
6
LapatinibApproved March 2007Phase 0296231277-92-2, 388082-78-8208908, 9941095
Synonyms:
1xkk
231277-92-2
388082-78-8
4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
AB1004631
AC-1314
AC1L4LL4
AKOS005145766
CHEBI:49603
CHEMBL1201179
CHEMBL554
CID11557040
CID208908
D04024
D08108
DB01259
DB02584
EN002712
FMM
GSK 572016
GSK572016
GW 572016
GW 572016X
GW-2016
GW-572016
GW-572016F
GW2016
GW572016
HMS2089H10
I01-1247
 
Kinome_3684
Kinome_3685
LAPATINIB DITOSYLATE MONOHYDRATE
LS-187029
LS-187771
Lapatinib
Lapatinib (INN)
Lapatinib Ditosylate
Lapatinib [INN]
Lapatinib ditosylate
Lapatinib ditosylate (USAN)
Lapatinib tosilate hydrate
Lapatinib tosilate hydrate (JAN)
Lapatinib, Tykerb, GW572016
N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine
N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
NCGC00167507-01
NSC745750
TL80090051
Tycerb
Tykerb
Tykerb (TN)
Tyverb
UNII-0VUA21238F
lapatinib
lapatinib ditosylate
nchembio866-comp20
7insulin4401

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast CancerCompletedNCT00600275Phase 1, Phase 2
2Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-MyalgiaNot yet recruitingNCT02024568Phase 2
3AZD2281 Plus Carboplatin to Treat Breast and Ovarian CancerActive, not recruitingNCT01445418Phase 1
4Insulin Resistance and Breast CancerCompletedNCT00304941
5Metabolic Syndrome as Modifiable Risk Factor for Breast CancerRecruitingNCT01172886
6Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary PresentationRecruitingNCT02664389
7Concentration and Activity of Lapatinib in Vestibular SchwannomasRecruitingNCT00863122Phase 0
8Feasibility of Lifestyle Intervention in BRCA1/2 Mutation CarriersActive, not recruitingNCT02087592

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

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Anatomical Context for Sporadic Breast Cancer

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MalaCards organs/tissues related to Sporadic Breast Cancer:

34
Breast, Endothelial

Animal Models for Sporadic Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Sporadic Breast Cancer:

39 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5ATM, BRCA1, ESR1, ESR2, PTEN, TP53
2MP:00053698.3BRCA1, ERBB2, ESR1, ESR2, PGR, PTEN
3MP:00053818.2BRCA1, BRCA2, ERBB2, ESR1, ESR2, PTEN
4MP:00107718.0ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
5MP:00053907.6BRCA1, BRCA2, ERBB2, ESR1, ESR2, PGR
6MP:00053807.5ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
7MP:00053897.2ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
8MP:00053877.2ATM, BRCA1, BRCA2, CHEK2, ESR1, ESR2
9MP:00053977.1ATM, BRCA1, BRCA2, CHEK2, ESR1, ESR2
10MP:00053717.1BRCA1, BRCA2, ERBB2, ESR1, ESR2, FANCD2
11MP:00028737.0BARD1, BRCA1, BRCA2, ERBB2, ESR1, ESR2
12MP:00053797.0ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
13MP:00053866.5ATM, BRCA1, BRCA2, ERBB2, ESR1, ESR2
14MP:00036316.4ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
15MP:00053766.1ATM, BRCA1, BRCA2, CHEK2, ERBB2, ESR1
16MP:00053786.1ATM, BARD1, BRCA1, BRCA2, ERBB2, ESR1
17MP:00020066.0ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
18MP:00053845.8ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
19MP:00107685.6ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2

Publications for Sporadic Breast Cancer

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Articles related to Sporadic Breast Cancer:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility. (26650628)
2016
2
Association between genetic variants of EGF-containing fibulin-like extracellular matrix protein1 gene and sporadic breast cancer in a Chinese Han population. (27048115)
2016
3
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer. (26430163)
2015
4
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. (24556691)
2014
5
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis. (24464625)
2014
6
Combined microRNA and ER expression: a new classifier for familial and sporadic breast cancer patients. (25406994)
2014
7
MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. (23860775)
2013
8
Imaging features of sporadic breast cancer in women under 40 years old: 97 cases. (23918218)
2013
9
Potential clinical significance of ERI^ ON promoter methylation in sporadic breast cancer. (23794253)
2013
10
Contralateral risk-reducing mastectomy in sporadic breast cancer. (23725708)
2013
11
The TP53 gene polymorphisms and survival of sporadic breast cancer patients. (21365326)
2012
12
Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer. (22968923)
2012
13
Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China. (21912605)
2011
14
Familial and sporadic breast cancers: differences in clinical, histopathological, and immunohistochemical features. (20308044)
2011
15
Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer. (22220212)
2011
16
BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer. (20877436)
2010
17
AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers. (21321378)
2010
18
Silencing of estrogen receptor alpha (ERalpha) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer. (18814026)
2009
19
Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. (19115204)
2009
20
Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. (17952592)
2008
21
Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer. (18711133)
2008
22
Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. (18425370)
2008
23
Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg>Pro polymorphism. (17945002)
2007
24
Distinction between hereditary and sporadic breast cancer on the basis of clinicopathological data. (16603649)
2006
25
The estrogen receptor alpha C975G variant in familial and sporadic breast cancer: a case-control study. (16886637)
2006
26
Estrogen and progesterone receptor gene polymorphisms and sporadic breast cancer risk: a Spanish case-control study. (16477637)
2006
27
Frequency analysis of apoptosis in sporadic breast cancer. (17285763)
2006
28
Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years. (16714331)
2006
29
Sporadic breast cancer among relatives of BRCA mutation carriers. (16301869)
2005
30
Significant involvement of CCR2-64I and CXCL12-3a in the development of sporadic breast cancer. (15121787)
2004
31
BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. (15365993)
2004
32
Loss of heterozygosity on chromosome 13q: suggestion of a candidate tumor suppressor gene in sporadic breast cancer. (14997045)
2004
33
A role for BRCA1 in sporadic breast cancer. (12698194)
2003
34
Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. (12888106)
2003
35
Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. (12406554)
2002
36
Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer. (12151349)
2002
37
Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. (11071387)
2000
38
Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines. (10717253)
2000
39
Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (10534407)
1999
40
ATM protein synthesis patterns in sporadic breast cancer. (10748873)
1999
41
Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer. (10472782)
1999
42
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. (9537235)
1998
43
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. (9872332)
1998
44
Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient. (9665150)
1998
45
The genetics of sporadic breast cancer. (9108590)
1997
46
Frequent allele loss on 9p21-22 defines a smallest common region in the vicinity of the CDKN2 gene in sporadic breast cancer. (8889502)
1996
47
Low Frequency Loss of Heterozygosity in the BRCA1 Region in Japanese Sporadic Breast Cancer. (11091753)
1996
48
Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. (8589680)
1995
49
Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development. (8181852)
1994
50
Chromosomes 1 and 16 in sporadic breast cancer. (7509631)
1993

Variations for Sporadic Breast Cancer

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Expression for genes affiliated with Sporadic Breast Cancer

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Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for genes affiliated with Sporadic Breast Cancer

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Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathwaysScoreTop Affiliating Genes
19.9CHEK2, TP53
29.7ATM, BRCA1, TP53
39.7ATM, BRCA1, TP53
49.7ATM, BRCA2, RAD51
5
Show member pathways
9.6ATM, CHEK2, TP53
6
Show member pathways
9.6ATM, CHEK2, TP53
7
Show member pathways
9.6ATM, CHEK2, TP53
89.6ATM, BRCA1, XRCC1
9
Show member pathways
9.5ATM, BRCA1, BRCA2, RAD51
10
Show member pathways
9.4BRCA1, CHEK2, ESR1, PGR
119.4ESR1, ESR2
12
Show member pathways
9.4BRCA2, ERBB2, RAD51, TP53
139.4ERBB2, PTEN, TP53
14
Show member pathways
9.3ATM, CHEK2, ERBB2, TP53
159.2BRCA2, CHEK2, ESR1, XRCC1
16
Show member pathways
9.2ESR1, ESR2, PGR
179.2ATM, ESR2, PGR
18
Show member pathways
9.2ATM, ERBB2, PTEN, TP53
19
Show member pathways
9.1BRCA1, BRCA2, FANCD2, RAD51
20
Show member pathways
9.1ATM, BARD1, BRCA1, BRCA2, RAD51
21
Show member pathways
9.1ATM, BARD1, BRCA1, BRCA2, RAD51
22
Show member pathways
9.1ATM, CHEK2, PTEN, TP53
23
Show member pathways
9.0ATM, BARD1, BRCA1, CHEK2, TP53
24
Show member pathways
9.0ATM, BARD1, BRCA1, CHEK2, TP53
258.9ATM, BRCA1, ERBB2, PTEN, TP53
268.9BRCA2, ERBB2, PTEN, RAD51, TP53
27
Show member pathways
8.9ATM, BRCA1, CHEK2, PTEN, TP53
28
Show member pathways
8.7ATM, BRCA1, BRCA2, ERBB2, PTEN, TP53
298.6ATM, BRCA1, CHEK2, RAD51, TP53, XRCC1
30
Show member pathways
8.5ATM, BARD1, BRCA1, BRCA2, CHEK2, RAD51
31
Show member pathways
8.5ATM, BARD1, BRCA1, CHEK2, PTEN, TP53
32
Show member pathways
8.5ATM, BRCA1, CHEK2, FANCD2, RAD51, TP53
338.4ATM, BARD1, BRCA1, FANCD2, RAD51, TP53
348.4ATM, BARD1, BRCA1, CHEK2, FANCD2, TP53
35
Show member pathways
8.0ATM, BRCA1, CHEK2, FANCD2, PTEN, RAD51
36
Show member pathways
7.9ATM, BARD1, BRCA1, CHEK2, FANCD2, PTEN
37
Show member pathways
7.9ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
38
Show member pathways
7.9ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
397.8ATM, BARD1, BRCA1, BRCA2, CHEK2, ESR1
40
Show member pathways
7.4ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2
417.0ATM, BRCA1, BRCA2, CHEK2, ERBB2, ESR1
42
Show member pathways
6.6ATM, BRCA1, CHEK2, ERBB2, ESR1, ESR2
43
Show member pathways
6.6ATM, BARD1, BRCA1, CHEK2, ESR1, ESR2
44
Show member pathways
6.4ATM, BARD1, BRCA1, BRCA2, CHEK2, ESR1

GO Terms for genes affiliated with Sporadic Breast Cancer

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Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-A complexGO:007053110.6BARD1, BRCA1
2BRCA1-BARD1 complexGO:003143610.6BARD1, BRCA1
3condensed chromosomeGO:000079310.0BRCA1, FANCD2, RAD51
4PML bodyGO:00166059.6CHEK2, PTEN, RAD51, TP53
5nucleusGO:00056345.6ATM, BARD1, BRCA1, BRCA2, CHEK2, ERBB2
6nucleoplasmGO:00056545.0ATM, BARD1, BRCA1, BRCA2, CHEK2, EMSY

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1chromosome breakageGO:003105210.6BRCA1, BRCA2
2chordate embryonic developmentGO:004300910.6BRCA1, BRCA2
3determination of adult lifespanGO:000834010.6ATM, TP53
4mitotic recombination-dependent replication fork processingGO:199042610.6BRCA2, RAD51
5protein K6-linked ubiquitinationGO:008502010.5BARD1, BRCA1
6DNA damage induced protein phosphorylationGO:000697510.4ATM, CHEK2
7DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.4BRCA1, BRCA2, TP53
8response to X-rayGO:001016510.2BRCA2, RAD51, TP53
9DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697710.1ATM, CHEK2, TP53
10replicative senescenceGO:009039910.1ATM, CHEK2, TP53
11double-strand break repairGO:000630210.1BRCA1, BRCA2, CHEK2
12Sertoli cell proliferationGO:006001110.0ESR1, ESR2
13double-strand break repair via nonhomologous end joiningGO:000630310.0ATM, BARD1, BRCA1
14response to nutrientGO:000758410.0BRCA1, BRCA2, PTEN
15intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.9ATM, BRCA1, BRCA2, CHEK2
16DNA double-strand break processingGO:00007299.9ATM, BARD1, BRCA1
17regulation of apoptotic processGO:00429819.9ATM, BRCA1, ESR1, TP53
18double-strand break repair via homologous recombinationGO:00007249.6ATM, BRCA1, BRCA2, RAD51, XRCC1
19response to estrogenGO:00436279.5BRCA1, ESR1, ESR2
20DNA repairGO:00062819.5ATM, EMSY, RAD51, XRCC1
21response to gamma radiationGO:00103329.5BRCA2, CHEK2, FANCD2, TP53
22Sertoli cell developmentGO:00600099.4ESR1, ESR2
23strand displacementGO:00007329.4ATM, BARD1, BRCA1, BRCA2, RAD51
24DNA synthesis involved in DNA repairGO:00007319.4ATM, BARD1, BRCA1, BRCA2, RAD51
25positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.3ESR1, ESR2, PTEN
26regulation of signal transduction by p53 class mediatorGO:19017969.3ATM, BARD1, BRCA1, CHEK2, TP53
27cellular response to drugGO:00356909.0CHEK2, ESR2, TP53
28response to estradiolGO:00323559.0BRCA1, BRCA2, ESR1, PTEN
29positive regulation of transcription, DNA-templatedGO:00458938.5BRCA1, BRCA2, CHEK2, ESR1, ESR2, TP53
30positive regulation of apoptotic processGO:00430658.3ATM, BARD1, ESR2, PTEN, TP53
31cellular response to DNA damage stimulusGO:00069747.8ATM, BARD1, BRCA1, BRCA2, CHEK2, FANCD2

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA bindingGO:003805210.1ESR1, ESR2
2DNA polymerase bindingGO:007018210.1FANCD2, RAD51
3estrogen receptor activityGO:003028410.1ESR1, ESR2
4estrogen response element bindingGO:003405610.0ESR1, ESR2
5damaged DNA bindingGO:00036849.9BRCA1, TP53, XRCC1
6steroid hormone receptor activityGO:00037079.8ESR1, ESR2, PGR
7core promoter sequence-specific DNA bindingGO:00010469.6ESR1, ESR2, TP53
8steroid bindingGO:00054969.5ESR1, ESR2, PGR
9identical protein bindingGO:00428028.5CHEK2, ERBB2, ESR1, PTEN, RAD51, TP53
10enzyme bindingGO:00198997.3BRCA1, ESR1, ESR2, GSTM1, PGR, PTEN

Sources for Sporadic Breast Cancer

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet