MCID: SPR009
MIFTS: 33

Sporadic Breast Cancer malady

Cancer category

Summaries for Sporadic Breast Cancer

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33MalaCards
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MalaCards: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to familial breast cancer and breast cancer, somatic. An important gene associated with Sporadic Breast Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Chks in Checkpoint Regulation and Fanconi Anemia pathway. Affiliated tissues include liver, spleen and colon.

Aliases & Classifications for Sporadic Breast Cancer

Sources:
8Disease Ontology, 61UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

sporadic breast cancer 8
sporadic breast carcinoma 61


External Ids:

Disease Ontology8 DOID:8029
NCIt40 C7566

Related Diseases for Sporadic Breast Cancer

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Sporadic Breast Cancer:



Diseases related to sporadic breast cancer

Clinical Features for Sporadic Breast Cancer

Drugs & Therapeutics for Sporadic Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sporadic Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Sporadic Breast Cancer

Search NIH Clinical Center for Sporadic Breast Cancer

Search CenterWatch for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

Sources:
33MalaCards
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MalaCards organs/tissues related to Sporadic Breast Cancer:

33
Liver, Spleen, Colon, Pancreas, Breast, Prostate, T cells, B cells, Endothelial

Animal Models for Sporadic Breast Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sporadic Breast Cancer

Sources:
51PubMed
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Articles related to Sporadic Breast Cancer:

(show top 50)    (show all 300)
idTitleAuthorsYear
1
MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. (23860775)
2013
2
Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. (22218884)
2012
3
Clinical implications of ERI^ methylation on sporadic breast cancers in Chinese women. (22105146)
2012
4
Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients. (22038723)
2012
5
BRCA1 promoter methylation status does not predict response to tamoxifen in sporadic breast cancer patients. (22706629)
2012
6
Evaluation of Methylation Status in the 5'UTR Promoter Region of the DBC2 Gene as a Biomarker in Sporadic Breast Cancer. (23626933)
2012
7
Low prevalence of BRCA1 and BRCA2 mutations in the sporadic breast cancer of Spanish population. (21918853)
2012
8
BRCA1 protein expression and its correlation with ER/PR status in sporadic and familial breast cancer in Eastern Indian patients--a hospital based study. (23469566)
2011
9
Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk. (21708019)
2011
10
Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor. (20043118)
2010
11
AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers. (21321378)
2010
12
Analysis of the polymorphisms in non-homologous DNA end joining (NHEJ) gene Ku70 and Ligase IV in sporadic breast cancer in women. (20496270)
2010
13
Effect of point substitutions in the MnSOD, GPX1, and GSTP1 genes on the risk of familial and sporadic breast cancers in residents of the AltaA- region of the Russian Federation]. (21434422)
2010
14
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (18950845)
2009
15
Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer. (18711133)
2008
16
The 'Pokemon' (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer. (21892298)
2008
17
EGFR mutations in exons 18-21 in sporadic breast cancer. (17220285)
2007
18
Mutation analysis of the DBC2 gene in sporadic and familial breast cancer. (17653899)
2007
19
PML protein expression in hereditary and sporadic breast cancer. (17822314)
2007
20
Hypermethylation of tumor suppressor genes BRCA1, p16 and 14-3-3sigma in serum of sporadic breast cancer patients. (17264521)
2007
21
Estrogen receptor status could modulate the genomic pattern in familial and sporadic breast cancer. (18094411)
2007
22
FANCD2 associated with sporadic breast cancer risk. (16679306)
2006
23
Comparison of genomic abnormalities between BRCAX and sporadic breast cancers studied by comparative genomic hybridization. (15540206)
2005
24
Microsatellite instability and expression of mismatch repair genes in sporadic endometrial cancer coexisting with colorectal or breast cancer. (15583795)
2005
25
An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in eastern Finland: three candidate regions found. (15668479)
2005
26
Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk. (15026620)
2004
27
Surfaced-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) differentiation of serum protein profiles of BRCA-1 and sporadic breast cancer. (15383419)
2004
28
Clustering of variations and haplotype analysis in the highly variable region of exon 11 of BRCA1 in Chinese women with sporadic breast cancer. (12402341)
2002
29
Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers. (11956301)
2002
30
Cyclin D2 expression in familial and sporadic breast cancer. (12375011)
2002
31
Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability. (12173039)
2002
32
Somatic mutations in the BRCA2 gene and high frequency of allelic loss of BRCA2 in sporadic male breast cancer. (11948477)
2002
33
Molecular alterations in sporadic breast cancer. (12413631)
2002
34
Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer. (11737895)
2001
35
Why are the majority of hereditary cases of early-onset breast cancer sporadic? A simulation study. (10952097)
2000
36
Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. (11071387)
2000
37
TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer. (9933562)
1999
38
Histological type and syncytial growth pattern affect E-cadherin expression in a multifactorial analysis of a combined panel of sporadic and BRCA1-associated breast cancers. (10449606)
1999
39
Somatic genetic alterations in BRCA2-associated and sporadic male breast cancer. (9892109)
1999
40
Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer. (10467410)
1999
41
Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient. (9665150)
1998
42
Cytogenetic evaluation of 20 sporadic breast cancer patients and their first degree relatives. (9596490)
1998
43
The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer. (9679946)
1998
44
Low Frequency Loss of Heterozygosity in the BRCA1 Region in Japanese Sporadic Breast Cancer. (11091753)
1996
45
Association of allelic losses on human chromosomal arms 11Q and 16Q in sporadic breast cancer. (8797873)
1996
46
Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer. (8630282)
1996
47
Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development. (8181852)
1994
48
Chromosomes 1 and 16 in sporadic breast cancer. (7509631)
1993
49
Familial versus sporadic breast cancer. (1516029)
1992
50
Polymorphism of the c-Ha-ras-1 proto-oncogene in sporadic and familial breast cancer. (2668204)
1989

Genetic Variations for Sporadic Breast Cancer

Expression for genes affiliated with Sporadic Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for genes affiliated with Sporadic Breast Cancer

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7HUS1, FANCF, BRCA1
2
Hide members
10.6FANCF, BRCA1
310.6HUS1, BRCA1

Compounds for genes affiliated with Sporadic Breast Cancer

GO Terms for genes affiliated with Sporadic Breast Cancer

Sources:
16Gene Ontology
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Biological processes related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to UVGO:00941110.6HUS1, CDKN2D

Products for genes affiliated with Sporadic Breast Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sporadic Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet