MCID: SPR009
MIFTS: 33

Sporadic Breast Cancer malady

Cancer diseases category

Summaries for Sporadic Breast Cancer

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32MalaCards
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MalaCards: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to breast cancer and breast disease. An important gene associated with Sporadic Breast Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Chks in Checkpoint Regulation and Fanconi Anemia pathway. Affiliated tissues include breast, colon and testes.

Aliases & Classifications for Sporadic Breast Cancer

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

sporadic breast cancer 8
sporadic breast carcinoma 60


External Ids:

Disease Ontology8 DOID:8029
NCIt39 C7566

Related Diseases for Sporadic Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.9SCGB3A1, FANCF, BRCA1
2breast disease10.4
3retinoblastoma10.1
4estrogen-receptor negative breast cancer10.1
5progesterone-receptor negative breast cancer10.1
6xeroderma pigmentosum10.1
7cowden disease10.1
8bilateral breast cancer10.1
9chromosomal disease10.1
10ovarian cancer10.1

Graphical network of diseases related to Sporadic Breast Cancer:



Diseases related to sporadic breast cancer

Clinical Features for Sporadic Breast Cancer

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Drugs & Therapeutics for Sporadic Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sporadic Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Sporadic Breast Cancer

Search NIH Clinical Center for Sporadic Breast Cancer

Search CenterWatch for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

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Anatomical Context for Sporadic Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Sporadic Breast Cancer:

32
Breast, Colon, Testes, Liver, Spleen, Endothelial, Pancreas, Prostate

Animal Models for Sporadic Breast Cancer or affiliated genes

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Publications for Sporadic Breast Cancer

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50PubMed
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Articles related to Sporadic Breast Cancer:

(show top 50)    (show all 300)
idTitleAuthorsYear
1
Association of BRCA1 promoter methylation with rs11655505 (c.2265C>T) variants and decreased gene expression in sporadic breast cancer. (23263908)
2013
2
Quantification of PKC family genes in sporadic breast cancer by qRT-PCR: evidence that PKCI^/I> overexpression is an independent prognostic factor. (22511072)
2012
3
Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing. (21553119)
2012
4
Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer. (23217244)
2012
5
Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer. (22116506)
2012
6
Polymorphisms in the 5'- and 3'-untranslated region of the VEGF gene and sporadic breast cancer risk and clinicopathologic characteristics. (20981515)
2011
7
Lack of influence of glutathione S-transferase gene deletions in sporadic breast cancer in Pakistan. (22126558)
2011
8
PD-1 polymorphisms are associated with sporadic breast cancer in Chinese Han population of Northeast China. (21487727)
2011
9
Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer. (20363922)
2010
10
Diagnostic value of BRCA1 and p16 gene methylation in sporadic breast cancer]. (19622308)
2009
11
Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. (19115204)
2009
12
Polymorphisms GSTM1 and GSTT1 and sporadic breast cancer mammographic features]. (18392488)
2008
13
Single nucleotide polymorphisms in the hypoxia-inducible factor-1alpha (HIF-1alpha) gene in human sporadic breast cancer. (18279708)
2008
14
Mutation screening of the BRCA1 gene in sporadic breast cancer in southern Chinese populations. (18835712)
2008
15
Is mitochondrial DNA variation associated with sporadic breast cancer risk? (18199560)
2008
16
Influence of germline polymorphisms of GSTT1, GSTM1, and GSTP1 in familial versus sporadic breast cancer susceptibility and survival. (18080216)
2008
17
A new polymorphism in the coding region of exon four in HSD17B2 in relation to risk of sporadic and hereditary breast cancer. (17260097)
2007
18
XPD Lys751Gln polymorphism analysis in women with sporadic breast cancer. (18459458)
2007
19
A high risk of occurrence of sporadic breast cancer in individuals with the 104NN polymorphism of the COL18A1 gene. (16807676)
2006
20
Sporadic amyotrophic lateral sclerosis and breast cancer: Hyaline conglomerate inclusions lead to identification of SOD1 mutation. (16423367)
2006
21
The role of BRCA1 gene mutations and apoptosis phenomenon in sporadic breast cancer. (16334977)
2005
22
Loss of heterozygosity at 17p13.3-ter, distal to TP53, correlates with negative hormonal phenotype in sporadic breast cancer. (16012732)
2005
23
Significant involvement of CCR2-64I and CXCL12-3a in the development of sporadic breast cancer. (15121787)
2004
24
The association of NAT2 polymorphisms with sporadic breast cancer]. (15285615)
2004
25
Loss of heterozygosity on chromosome 13q: suggestion of a candidate tumor suppressor gene in sporadic breast cancer. (14997045)
2004
26
Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome. (15355907)
2004
27
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. (14651845)
2003
28
Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]. (14714492)
2003
29
Rad52 gene mutations in breast/ovarian cancer families and sporadic ovarian carcinoma patients. (12883740)
2003
30
Sporadic breast cancer in young women: prevalence of loss of heterozygosity at p53, BRCA1 and BRCA2. (11857409)
2002
31
Correlation between morphology, immunohistochemistry and molecular pathology in hereditary and sporadic breast cancer cases. (12227949)
2002
32
Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer. (11400122)
2001
33
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. (11404819)
2001
34
Significantly lower rates of BRCA1/BRCA2 founder mutations in Ashkenazi women with sporadic compared with familial early onset breast cancer. (10885601)
2000
35
Low frequency of microsatellite instability in sporadic breast cancer. (10812001)
2000
36
Association of A vitamin D receptor polymorphism with sporadic breast cancer development. (10597185)
1999
37
Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (10534407)
1999
38
Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer. (10471049)
1999
39
Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics. (10208417)
1999
40
Suppression of ING1 expression in sporadic breast cancer. (10498868)
1999
41
p73 mutations are not detected in sporadic and hereditary breast cancer. (10634515)
1999
42
Two regions of deletion in 9p23-24 in sporadic breast cancer. (10463588)
1999
43
Identification of missense and truncating mutations in the BRCA1 gene in sporadic and familial breast and ovarian cancer. (9523200)
1998
44
The genetics of sporadic breast cancer. (9108590)
1997
45
Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium. (9167459)
1997
46
Methylation of the BRCA1 gene in sporadic breast cancer. (9269993)
1997
47
Mutation analysis of the transforming growth factor beta type II receptor in sporadic human cancers of the pancreas, liver, and breast. (8687435)
1996
48
Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer. (8616837)
1996
49
Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. (7795653)
1995
50
Infrequent occurrence of microsatellite instability in sporadic and familial breast cancer. (8652265)
1995

Genetic Variations for Sporadic Breast Cancer

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Expression for genes affiliated with Sporadic Breast Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for genes affiliated with Sporadic Breast Cancer

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7HUS1, FANCF, BRCA1
2
Hide members
10.6FANCF, BRCA1
310.6HUS1, BRCA1

Compounds for genes affiliated with Sporadic Breast Cancer

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GO Terms for genes affiliated with Sporadic Breast Cancer

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16Gene Ontology
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Biological processes related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to UVGO:00941110.6HUS1, CDKN2D

Products for genes affiliated with Sporadic Breast Cancer

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Sources for Sporadic Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet