Sporadic Breast Cancer malady

MalaCards: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to breast cancer and peutz-jeghers syndrome. An important gene associated with Sporadic Breast Cancer is PHB (prohibitin), and among its related pathways are Fanconis Anaemia Pathway and Pancreatic cancer. The compounds vincristine and egcg have been mentioned in the context of this disorder. Affiliated tissues include breast, t cells and b cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

sporadic breast cancer 6 8 sporadic breast carcinoma 43

Diseases related to sporadic breast cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 753)

id	Related Disease	Score	Top Affiliating Genes
1	breast cancer	40.7	RAD51, CHEK2, BARD1, XRCC3, ATM, PHB
2	peutz-jeghers syndrome	29.0	BRCA2, CDKN3, TP53, TP73, PTEN, CYP19A1
3	breast cancer susceptibility	26.8	NBN, NAT2, BRCA1, BRCA2, BRCA3, BRIP1
4	breast carcinoma	22.8	PIK3CG, PCNA, RB1, RBBP8, NBN, VIM
5	carcinoma	22.2	PIK3CG, RFC1, NCOR2, VTCN1, PCNA, RB1
6	retinoblastoma	18.7	PIK3CG, RFC1, PCNA, RB1, RBBP8, NBN
7	hypoxia	18.7	PIK3CG, PCNA, RB1, NBN, BRCA1, VEGFA
8	fanconi's anemia	14.3	BRCA2, BRIP1, FANCD2, FANCA, FANCE, FANCF
9	fanconi anemia, complementation group b	14.2	FANCD2, FANCA, FANCE, FANCF, FANCC, FANCG
10	fanconi anemia, complementation group m	14.2	FANCD2, FANCA, FANCE, FANCF, FANCC, FANCG
11	hereditary pancreatitis	14.1	RBBP8, NBN, BRCA1, BRCA2, BRIP1, RAD51
12	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	14.0	NBN, RAD50, CHEK2, MRE11A
13	progesterone resistance	13.9	HSD17B2, ESR1, ESR2, PGR
14	fallopian tube carcinoma	13.8	BRCA1, BRCA2, ERBB2
15	leukopenia	13.8	BRCA2, BRIP1, LIG4, GSTM1, GSTT1, FANCD2
16	esophageal atresia	13.8	GSTM1, GSTP1, GSTT1, FANCA, SOX2
17	seckel syndrome	13.8	RBBP8, LIG4, CHEK1, ATR, ATM, FANCA
18	uterine adnexa cancer	13.8	MSH2, MLH1, ESR1, ESR2, CYP19A1
19	diffuse gastric cancer	13.8	XRCC3, CDH1, GSTM1, GSTP1, GSTT1, ERCC2
20	cowden disease	13.8	BRCA2, AKT1, PTEN, STK11
21	pancytopenia	13.8	NBN, LIG4, MGMT, FANCA, FANCC, FANCG
22	gender identity disorder	13.8	ESR1, ESR2, CYP19A1, PGR
23	retinoblastoma fa - friedreich ataxia	13.8	RB1, BRCA2, MDM2
24	progesterone-receptor negative breast cancer	13.7	RASSF1, CCND2, ESR1, ERBB2, PGR
25	small intestine carcinoma	13.7	MSH2, MSH6, MLH1
26	hypospadias	13.7	GSTM1, GSTT1, ESR1, ESR2, CYR61, CYP1A1
27	muir-torre syndrome	13.7	MSH2, MSH6, MLH1, FHIT, PMS1
28	ovarian cancer	13.7	RB1, NBN, BRCA1, BRCA2, RAD50, CHEK2
29	microcephaly	13.7	NBN, BRCA1, RAD50, LIG4, CHEK1, ATR
30	inflammatory breast carcinoma	13.7	CDH1, MDM2, ESR1, ERBB2, PROX1
31	mayer-rokitansky-kuster-hauser syndrome	13.7	NBN, BRCA1, BRCA2, VDR, LIG4, PARP1
32	oligodendroglioma	13.6	CDKN2A, MGMT, TP73, PTEN
33	primary pigmented nodular adrenocortical disease	13.6	ESR1, ESR2, CYP19A1, NR3C1, PGR
34	malignant mixed mullerian tumor	13.6	VIM, ESR1, ABL1, PGR
35	stomach carcinoma	13.6	RASSF1, CDKN2A, CDH1, MLH1, CCND1, ABCB1
36	frontotemporal dementia	13.6	BCHE, YWHAQ, CELF3, JUN, CDKN3, CDK1
37	endometrial stromal sarcoma	13.6	VIM, ESR1, ESR2, CYP19A1, PGR
38	premature ovarian failure	13.6	ATM, ESR1, ESR2, PTEN, CYP17A1, CYP19A1
39	brain cancer	13.6	GSTM1, GSTM3, GSTT1, CYP1A1, NFKB1
40	gynecomastia	13.6	BRCA1, BRCA2, ESR1, ERBB2, CYP17A1, CYP19A1
41	glassy cell carcinoma of the cervix	13.6	ESR1, ERBB2, PGR
42	skin benign neoplasm	13.6	MSH2, MSH6, JUN, MLH1, MGMT, ERCC2
43	alcoholic pancreatitis	13.6	NAT2, GSTM1, GSTP1, GSTT1, ABCB1, SOD2
44	benign metastasizing leiomyoma	13.6	VIM, ESR1, CYP19A1, PGR
45	adenocarcinoma in situ	13.5	VIM, CDKN1A, CDKN2A, ESR1, PGR
46	lynch syndrome	13.5	MSH2, MLH1, MKI67, MGMT
47	hodgkin's lymphoma	13.5	PIK3CG, BRCA1, BRCA2, ATM, CD40, MDM2
48	sertoli-leydig cell tumor	13.5	VIM, ESR1, CYP17A1, CYP19A1, PGR
49	bladder cancer susceptibility	13.5	NAT2, PARP1, MTHFR, XRCC1, GSTM1, GSTP1
50	hermaphroditism	13.5	BRCA2, GSTP1, MAPK8, MAPK9, CYP1A1, CYP1B1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sporadic breast cancer:

²²

MGI Mouse Phenotypes related to sporadic breast cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	BRCA1, RAD50, LAMC1, ATR, CDKN2D, MEF2C
2	endocrine/exocrine gland phenotype	MP:0005379	10.6	NBN, BRCA1, BRCA2, MYT1, RAD50, LAMC1
3	craniofacial phenotype	MP:0005382	10.2	NCOR2, NBN, LMO4, RAD17, LIG4, UHRF1
4	other phenotype	MP:0005395	9.4	LAMC1, MRE11A, CDKN2A, ESR2, TP73, NOS2
5	renal/urinary system phenotype	MP:0005367	9.4	BRCA1, LAMC1, ATR, CDKN1A, GSTZ1, MEF2C
6	embryogenesis phenotype	MP:0005380	9.0	RBBP8, NBN, VIM, BRCA1, BRCA2, LMO4
7	liver/biliary system phenotype	MP:0005370	9.0	NCOR2, VEGFA, RAD50, RAD17, LIG4, CLCA2
8	pigmentation phenotype	MP:0001186	8.9	RB1, BRCA1, MYC, ATR, CDKN2A, MED1
9	hematopoietic system phenotype	MP:0005397	8.8	VTCN1, PCNA, NBN, BRCA1, BRCA2, LMO4
10	normal phenotype	MP:0002873	8.5	VTCN1, BRCA1, BRCA2, VEGFA, MYC, BARD1
11	limbs/digits/tail phenotype	MP:0005371	8.4	RB1, BRCA1, BRCA2, VEGFA, VDR, LMO4
12	hearing/vestibular/ear phenotype	MP:0005377	8.4	RB1, VDR, LMO4, MYC, PARP1, CDKN1A
13	reproductive system phenotype	MP:0005389	8.1	NBN, BRCA1, BRCA2, VEGFA, VDR, RAD50
14	immune system phenotype	MP:0005387	7.6	VTCN1, NBN, VIM, BRCA1, BRCA2, VDR
15	no phenotypic analysis	MP:0003012	7.3	PCNA, RB1, VEGFA, MYC, PARP1, MTHFR
16	adipose tissue phenotype	MP:0005375	7.1	NCOR2, RB1, BRCA1, MYC, ATR, CDKN1A
17	integument phenotype	MP:0010771	7.1	PIK3CG, RB1, BRCA1, BRCA2, LMO4, MYC
18	behavior/neurological phenotype	MP:0005386	7.0	NCOR2, RB1, NBN, VIM, BRCA2, LMO4
19	nervous system phenotype	MP:0003631	6.4	RB1, NBN, BRCA1, LMO4, MYC, RAD50
20	vision/eye phenotype	MP:0005391	6.1	RB1, VIM, VEGFA, LMO4, MTHFR, LAMC1
21	mortality/aging	MP:0010768	5.9	NCOR2, VTCN1, RB1, RBBP8, BRCA1, BRCA2
22	digestive/alimentary phenotype	MP:0005381	5.8	NCOR2, RB1, BRCA1, BRCA2, VEGFA, VDR
23	skeleton phenotype	MP:0005390	5.5	PIK3CG, RB1, BRCA1, BRCA2, VEGFA, VDR
24	muscle phenotype	MP:0005369	5.4	PIK3CG, RB1, VIM, BRCA1, VEGFA, MYC
25	growth/size phenotype	MP:0005378	5.2	PIK3CG, NCOR2, RB1, NBN, BRCA1, BRCA2
26	tumorigenesis	MP:0002006	5.0	RB1, RBBP8, NBN, BRCA1, BRCA2, MYC
27	cardiovascular system phenotype	MP:0005385	4.4	PIK3CG, NCOR2, RB1, VIM, BRCA1, VEGFA
28	cellular phenotype	MP:0005384	2.5	PIK3CG, NCOR2, VTCN1, PCNA, RB1, RBBP8
29	homeostasis/metabolism phenotype	MP:0005376	2.2	PIK3CG, NCOR2, RB1, VIM, NAT2, BRCA1

Articles related to sporadic breast cancer:

(show top 50)    (show all 136)

id	Title	Authors	Year	Affiliating Genes
1	Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China. (21912605)	Shuang C.... Li D.	2011	CD40
2	Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk. (21708019)	Ricks-Santi L.J.... Shields P.G.	2011	RAD51, BRCA1
3	Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. (21113649)	Mohammad N.S.... Kutala V.K.	2011	MTHFR, RFC1
4	UHRF1 is associated with epigenetic silencing of BRCA 1 in sporadic breast cancer. (19943104)	Jin W.... Shao Z.M.	2010	DNMT1, BRCA1, EHMT2
5	A novel tumor suppressor gene RhoBTB2 (DBC2): frequen t loss of expression in sporadic breast cancer. (19937980)	Mao H.... Zhang L.	2010	RHOBTB2
6	Effect of point substitutions in the MnSOD, GPX1, an d GSTP1 genes on the risk of familial and sporadic breast cancers in residents of the AltaA- region of the Russian Federation]. (21434422)	Ermolenko N.A.... Filipenko M.L.	2010	GSTP1, SOD2, GPX1
7	B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population. (19903360)	Zhang J.... Li D.	2009	VTCN1
8	BRCA1 promoter methylation associated with poor survi val in Chinese patients with sporadic breast cancer. (19522853)	Chen Y.... Deng D.	2009	BRCA1
9	High resolution human leukocyte antigen (HLA) class I and class II allele typing in Mexican mestizo women with sporadic breast cancer: case-control study. (19196481)	CantA_ de LeA^n D.... Granados J.	2009	HLA-A, HLA-DQA1, HLA-DRB1
10	Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. (17952592)	Kriege M.... Klijn J.G.	2008	BRCA1, BRCA2
11	Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer. (18711133)	Lo S.H.... Zheng T.	2008	BRCA1
12	Methylation status of CpG islands at sites -59 to +96 in exon 1 of the BRCA2 gene varies in mammary tissue among women with sporadic breast cancer. (18776644)	Cucer N.... Ozkul Y.	2008	BRCA2
13	Contribution of XPD (Lys751Gln) and XRCC1 (Arg399Gln) Polymorphisms in Familial and Sporadic Breast Cancer Predisposition and Survival: An Indian Report. (19051060)	Syamala V.S.... Ankathil R.	2008	ERCC2, XRCC1
14	Polymorphisms GSTM1 and GSTT1 and sporadic breast cancer mammographic features (18392488)	Morais L.M.... Gurgel M.S.	2008	GSTT1, GSTM1
15	Copy number alterations of the H2AFX gene in sporadic breast cancer patients. (18206537)	Srivastava N.... Bamezai R.N.	2008	H2AFX
16	Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer: progesterone receptor B hypermethylation in breast cancer. (17896177)	Mc Cormack O.... Kerin M.J.	2008	PGR, S100A6
17	MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population. (18281248)	Lum S.S.... Sabapathy K.	2008	MDM2, TP53
18	Prevalence of BER gene polymorphisms in sporadic breast cancer. (18357393)	Ali M.F.... Chakravarti D.	2008	PARP1, APEX1, XRCC1
19	Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg>Pro polymorphism. (17945002)	Gochhait S.... Bamezai R.N.	2007	BRCA2
20	TGFBR1(*)6A and Int7G24A variants of transforming growth factor-beta receptor 1 in Swedish familial and sporadic breast cancer. (17848956)	Song B.... Lindblom A.	2007	TGFBR1
21	PML protein expression in hereditary and sporadic breast cancer. (17822314)	Plevova P.... Kolar Z.	2007	PCNA, BRCA2, PML
22	Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer. (17415710)	Versmold B.... Waha A.	2007	PROX1
23	Estrogen receptor status could modulate the genomic pattern in familial and sporadic breast cancer. (18094411)	Melchor L.... BenA-tez J.	2007	BRCA2
24	Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. (17825114)	Wang L.... Li D.	2007	CTLA4
25	Estrogen and progesterone receptor gene polymorphisms and sporadic breast cancer risk: a Spanish case-control study. (16477637)	Fernandez L.P.... Ribas G.	2006	PGR, ESR1
26	Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years. (16714331)	Lu J.... Wang L.E.	2006	NBN
27	Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer. (16846527)	Birgisdottir V.... Eyfjord J.E.	2006	TP53, BRCA1, BRCA2
28	FANCD2 associated with sporadic breast cancer risk. (16679306)	Barroso E.... Ribas G.	2006	FANCD2
29	Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. (17011986)	Valladares A.... Arenas Aranda D.J.	2006	LAMC1, CCNC, PLXNB3
30	A high risk of occurrence of sporadic breast cancer in individuals with the 104NN polymorphism of the COL18A1 gene. (16807676)	Lourenco G.J.... Lima C.S.	2006	COL18A1
31	Low prevalence of BRCA1 exon rearrangements in familial and young sporadic breast cancer patients. (16724249)	Ellis D.... Abbs S.J.	2006	BRCA1
32	BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. (16322213)	Wei M.... Olopade O.I.	2005	BRCA1
33	Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer. (15743496)	Cox D.G.... Hunter D.J.	2005	BRCA1
34	The association of NAT2 polymorphisms with sporadic breast cancer (15285615)	Artamonov V.V.... Zaletaev D.V.	2004	NAT2
35	Loss of heterozygosity of the BRCA1 and FHIT genes in patients with sporadic breast cancer from Southern Brazil. (15047740)	Santos S.C.... Ribeiro E.M.	2004	BRCA1, FHIT
36	Regulation of BRCA1 expression and its relationship to sporadic breast cancer. (12559046)	Mueller C.R.... Roskelley C.D.	2003	BRCA1
37	Abnormal methylation of several tumor suppressor genes in sporadic breast cancer (12942643)	Zemliakova V.V.... Nemtsova M.V.	2003	CDH1, RB1, MGMT
38	Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. (12406554)	Curran J.E.... Griffiths L.R.	2002	NFKB1, NFKBIA
39	Constitutional alterations of the ATM gene in early onset sporadic breast cancer. (12362033)	Maillet P.... Sappino A.P.	2002	ATM
40	A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency. (11494157)	Signori E.... Fazio V.M.	2001	BRCA1
41	Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer. (11400122)	Curran J.E.... Griffiths L.R.	2001	NR3C1
42	Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (10534407)	Savino M.... Savoia A.	1999	CPNE1, CPNE7
43	ATM protein synthesis patterns in sporadic breast cancer. (10748873)	Kairouz R.... Lee C.S.	1999	ATM
44	TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer. (9933562)	Su G.... Cowell J.K.	1999	TTC4
45	Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and hMSH3 in sporadic breast cancer. (10098729)	Benachenhou N.... Sinnett D.	1999	MLH1, PMS1
46	Germ-line BRCA1 mutations in women with sporadic breast cancer: clinical correlations. (9440731)	Garcia-PatiA+o E.... Bonilla F.	1998	BRCA1
47	Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells. (9778046)	Rice J.C.... Futscher B.W.	1998	BRCA1
48	Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. (8589680)	Stack M.... Heighway J.	1995	BCPR
49	Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. (7795653)	Thompson M.E.... Holt J.T.	1995	BRCA1
50	The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. (1540973)	Sato T.... Nakamura Y.	1992	PHB

Genes related to sporadic breast cancer according to GeneCards:

(show top 50)    (show all 189)

id	Symbol	Description	Score	GeneCards Section Context
1	PHB	prohibitin	11.1	Publications, Summaries
2	BCPR	Breast cancer-related regulator of TP53	11.0	Publications
3	BP1	Blood pressure QTL 1	11.0	Publications
4	EGID-7795	Methylation modifier for class I HLA	11.0	Publications
5	BRCA3	breast cancer 3	11.0	Publications
6	SLC35G6	solute carrier family 35, member G6	11.0	Publications
7	MIR146B	microRNA 146b	11.0	Publications
8	FABP9	fatty acid binding protein 9, testis	11.0	Publications
9	TTC4	tetratricopeptide repeat domain 4	11.0	Publications, Functions
10	SCGB3A1	secretoglobin, family 3A, member 1	11.0	Publications
11	NBR2	neighbor of BRCA1 gene 2 (non-protein coding)	11.0
12	EMG1	EMG1 nucleolar protein homolog (S. cerevisiae)	11.0	Publications
13	SHARPIN	SHANK-associated RH domain interactor	11.0	Publications
14	FANCF	Fanconi anemia, complementation group F	11.0	Publications
15	PLXNB3	plexin B3	11.0	Publications
16	GIPC3	GIPC PDZ domain containing family, member 3	11.0	Publications
17	MIR146A	microRNA 146a	11.0	Publications
18	CPNE7	copine VII	11.0	Publications
19	SRA1	steroid receptor RNA activator 1	11.0	Publications
20	LMO4	LIM domain only 4	11.0	Publications
21	GSTZ1	glutathione S-transferase zeta 1	11.0	Publications
22	RAD1	RAD1 homolog (S. pombe)	11.0	Publications
23	CELF3	CUGBP, Elav-like family member 3	11.0
24	ATRIP	ATR interacting protein	11.0	Publications
25	CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	11.0	Publications
26	BCCIP	BRCA2 and CDKN1A interacting protein	11.0	Publications
27	FANCE	Fanconi anemia, complementation group E	11.0	Publications
28	BRCA1	breast cancer 1, early onset	11.0	Publications
29	BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	11.0	Publications
30	NMI	N-myc (and STAT) interactor	11.0	Publications
31	CPNE1	copine I	11.0	Publications
32	RHOBTB2	Rho-related BTB domain containing 2	11.0	Publications
33	RAP2A	RAP2A, member of RAS oncogene family	11.0	Functions
34	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
35	HUS1	HUS1 checkpoint homolog (S. pombe)	11.0	Publications
36	GABRP	gamma-aminobutyric acid (GABA) A receptor, pi	11.0	Publications
37	ZNF350	zinc finger protein 350	11.0	Publications
38	EHF	ets homologous factor	11.0	Publications
39	GTF2E1	general transcription factor IIE, polypeptide 1, alpha 56kDa	11.0	Publications
40	FANCG	Fanconi anemia, complementation group G	11.0	Publications
41	CLDN1	claudin 1	11.0	Publications
42	CCNC	cyclin C	11.0	Publications
43	CDC34	cell division cycle 34 homolog (S. cerevisiae)	11.0	Publications
44	SHFM1	split hand/foot malformation (ectrodactyly) type 1	11.0	Publications
45	CLCA2	chloride channel accessory 2	11.0	Publications
46	GADD45A	growth arrest and DNA-damage-inducible, alpha	11.0	Publications
47	WEE1	WEE1 homolog (S. pombe)	11.0	Publications
48	VTCN1	V-set domain containing T cell activation inhibitor 1	11.0	Publications
49	UHRF1	ubiquitin-like with PHD and ring finger domains 1	11.0	Publications
50	C11orf30	chromosome 11 open reading frame 30	11.0	UniProt Related, Publications

Pathways related to sporadic breast cancer according to GeneDecks:

(show top 50)    (show all 229)

id	Pathway	Score	Top Affiliating Genes
1	Fanconis Anaemia Pathway36	11.0	BRCA1, BRCA2, RAD51, RAD50, BARD1, ATR
2	Pancreatic cancer20	10.9	BRCA2
3	DNA Damage Induced 14-3-3Sigma Signaling36	10.5	TP53, HUS1, BRCA1, RAD1, YWHAQ, ATR
4	DNA damage DNA-damage-induced responses10	10.5	PRKDC, ATM, CHEK2, ATR, CHEK1, BRCA1
5	DNA damage_DNA-damage-induced responses41	10.5	ATR, BRCA1, CHEK1, CHEK2, ATM, ABL1
6	BRCA1 Pathway36	10.3	RAD51, RAD50, CHEK1, CHEK2, BARD1, MSH2
7	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.2	BARD1, ATR, ATM, ATRIP, MDM2, FANCD2
8	Cell cycle Role of 14-3-3 proteins in cell cycle regulation10	10.2	CHEK1, HUS1, CDK1, ATR, YWHAQ, YWHAH
9	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation41	10.2	ATM, ATR, YWHAQ, YWHAH, CHEK1, HUS1
10	DNA Damage3	10.1	MSH2, MSH6, ATR, ATRIP, MRE11A, MGMT
11	DNA damage_Role of Brca1 and Brca2 in DNA repair41	10.0	BRIP1, RAD51, RAD50, CHEK2, BARD1, MSH2
12	DNA damage Role of Brca1 and Brca2 in DNA repair10	10.0	PCNA, H2AFX, TP53, NBN, BRCA1, BRCA2
13	Chks in Checkpoint Regulation36	9.9	PCNA, BRCA1, RAD50, RAD17, RAD1, CHEK1
14	Transcription P53 signaling pathway10	9.9	VEGFA, ATR, KAT2B, CDKN2A, APEX1, MAPK8
15	G2-M Phase Transition36	9.9	MDM2, CDKN1A, ATM, ATR, YWHAQ, YWHAH
16	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis10	9.8	YWHAQ, YWHAH, KAT2B, JUN, MEF2C, CARM1
17	Colorectal cancer20	9.8	TGFBR1, MSH2, TGFB1, TGFBR2, MAPK9, MAPK8
18	ATM Pathway36	9.8	NFKBIA, ABL1, H2AFX, GADD45A, TP73, TP53
19	Busulfan Pathway, Pharmacodynamics34	9.7	GSTM1, APEX1, MGMT, MLH1, GSTP1, MSH2
20	DNA Repair Mechanisms36	9.7	PCNA, BRCA1, BRCA2, RAD51, FANCA, FANCE
21	GADD45 Pathway36	9.6	ATM, ATR, BRCA1, PCNA, CCND2, CDKN1A
22	p53 signaling pathway20	9.6	CDKN2A, CDK1, CHEK1, CDKN1A, TP53, TP73
23	Neurotrophin signaling pathway20	9.6	JUN, ABL1, TP73, MAPK9, RPS6KA1, YWHAH
24	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.5	ABCB1, TP53, ERCC2, GPX1, MLH1, MSH2
25	p53 Signaling36	9.5	HIF1A, PML, HDAC2, EP300, GADD45A, ABL1
26	Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis41	9.4	EP300, IGF1R, AKT1, CARM1, YWHAH, MEF2C
27	Cyclins and Cell Cycle Regulation36	9.4	RB1, CDKN1A, MYT1, ATR, ATM, CDKN2A
28	G1-S Phase Transition36	9.3	CDKN1A, CDKN2D, CDKN2A, CCND2, CCND1, TGFB1
29	Transcription_P53 signaling pathway41	9.3	HDAC2, NFKB1, TP53, ERCC3, ERCC2, MAPK9
30	Glucocorticoid Receptor Signaling36	9.0	CDKN1A, JUN, NCOR2, NFKBIA, EP300, HDAC2
31	Immune response_MIF in innate immunity response41	8.9	NOS2, NFKB1, EP300, TP53, MAPK9, JUN
32	Melanoma20	8.9	RB1, CDKN2A, CDH1, MDM2, CCND1, IGF1R
33	Immune response MIF in innate immunity response10	8.9	IFNG, TP53, NOS2, NFKB1, NFKBIA, MAPK8
34	Cell Cycle / Checkpoint Control3	8.8	PCNA, RB1, NBN, BRCA1, BRCA2, BRIP1
35	DNA damage_ATM/ATR regulation of G1/S checkpoint41	8.8	PCNA, NBN, BRCA1, MYC, CHEK1, CHEK2
36	Bladder cancer20	8.6	MYC, ERBB2, VEGFA, CDKN1A, RASSF1, RB1
37	Glioma20	8.5	PTEN, TP53, AKT1, IGF1R, CCND1, MDM2
38	Small cell lung cancer20	8.4	NFKBIA, RB1, MYC, LAMC1, FHIT, CCND1
39	Chagas disease (American trypanosomiasis)20	8.4	PIK3CG, TGFB1, TGFBR1, TGFBR2, NFKBIA, NFKB1
40	Toxoplasmosis20	8.3	TGFB1, CD40, MAPK8, IFNG, AKT1, HLA-DQA1
41	Prostate cancer20	8.3	NFKBIA, EP300, MDM2, NFKB1, PTEN, CCND1
42	Signal transduction_AKT signaling41	8.2	TP53, NFKB1, PTEN, AKT1, IGF1R, CCND1
43	TGF-beta Signaling Pathways37	8.1	TGFB1, TGFBR1, TGFBR2, EP300, NFKB1, NR3C1
44	Pancreatic Adenocarcinoma36	7.9	CCNC, CCND2, MDM2, CDKN2A, CDKN2D, CDKN1A
45	Cell cycle20	7.9	ATM, CDKN1A, CDKN2D, CDKN2A, CDK1, MDM2
46	Chronic myeloid leukemia20	7.9	MDM2, CCND1, AKT1, TP53, NFKB1, NFKBIA
47	Colorectal Cancer Metastasis36	7.8	MLH1, CCND2, CCND1, AKT1, TP53, MSH2
48	Estrogen Pathway36	7.7	NFKB1, TGFB1, CXCL12, PELP1, HDAC2, EP300
49	Molecular Mechanisms of Cancer36	7.0	RB1, BRCA1, MYC, RAP2A, CHEK2, ATR
50	Pathways in cancer20	6.1	TP53, GSTP1, MDM2, MAPK8, MAPK9, CCND1

Compounds related to sporadic breast cancer according to GeneDecks:

(show top 50)    (show all 373)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.6	MGMT
2	egcg32	10.3	PIK3CG, MAPK8, NFKBIA, DNMT1, STAT1
3	threonine32	10.0	NBN, MT-ND2, MSH6, MEF2C, CTTN, CTLA4
4	h2o232	10.0	PIK3CG, BRCA1, BRCA2, RAD51, BCHE, CHEK1
5	bpde32	9.6	BRCA1, CHEK1, CHEK2, ATM, CDK1, GSTM1
6	mitomycin c32	9.4	PCNA, RB1, NBN, BRCA1, BRCA2, RAD51
7	caffeine32 34 9 18 9	13.4	PCNA, NAT2, BRCA1, VDR, RAD51, CHEK1
8	rapamycin32 42	10.3	PIK3CG, RB1, NBN, VIM, VEGFA, CHEK2
9	hydroxyurea32 9 9	11.2	PCNA, NBN, BRCA1, BRCA2, MYC, RAD51
10	o6-methylguanine32	9.1	PCNA, BRCA2, RAD51, RASSF1, MSH2, MSH6
11	crcs32	9.1	RB1, RASSF1, MSH2, MSH6, CDKN2A, CDH1
12	biotin32 9 18 9	12.0	PCNA, RB1, VIM, MSH2, MSH6, CDKN2A
13	sulforaphane32	8.9	PIK3CG, RB1, PARP1, JUN, CDKN1A, MGMT
14	proline32	8.8	VIM, BRCA1, BRCA2, MSH2, CDK1, CDH1
15	adpribose32	8.8	PIK3CG, PCNA, RB1, BRCA1, BRCA2, PARP1
16	arginine32	8.6	RFC1, VDR, RAD51, BCHE, XRCC1, MRE11A
17	aphidicolin32	8.5	PCNA, RB1, BRCA1, MYC, RAD51, CHEK1
18	gefitinib32 34 9 9	11.4	PIK3CG, VIM, VEGFA, RAD51, CDKN1A, CDKN3
19	oxaliplatin32 34 9 9	11.1	BRCA1, VEGFA, MTHFR, XRCC1, CDKN1A, CDK1
20	n-(4-hydroxyphenyl)retinamide32	8.0	RB1, VIM, MYC, PARP1, JUN, CDKN1A
21	n acetylcysteine32	8.0	PCNA, CHEK1, CHEK2, XRCC3, ATM, CDKN1A
22	geldanamycin32 9 9	9.9	PIK3CG, VEGFA, PARP1, JUN, CDKN1A, CDK1
23	suberoylanilide hydroxamic acid32	7.8	MYC, PARP1, XRCC6, CDKN1A, CDH1, MAPK8
24	progesterone32 42 9 18 9	11.8	NCOR2, PCNA, RB1, BRCA1, BRCA2, CHEK1
25	imatinib32 34 9 9	10.7	PIK3CG, VEGFA, MYC, RAD51, PARP1, CDKN1A
26	retinoid32	7.7	NCOR2, VIM, VDR, MYC, JUN, CDKN1A
27	ly29400232	7.6	PIK3CG, VEGFA, JUN, CDKN3, CDK1, CDH1
28	mg 13232 42	8.6	PIK3CG, NCOR2, PCNA, BRCA1, VDR, MYC
29	glutamate32	7.6	PCNA, VIM, VDR, LIG4, BCHE, MTHFR
30	lactacystin32	7.5	PIK3CG, BRCA1, VDR, MYC, PARP1, JUN
31	cysteine32	7.4	PCNA, NAT2, BRCA1, VDR, PARP1, MTHFR
32	5-aza-2deoxycytidine32	7.3	PCNA, VIM, BRCA1, MYC, RASSF1, SCGB3A1
33	camptothecin32 42 9 9	10.3	PIK3CG, PCNA, RB1, NBN, BRCA1, BRCA2
34	alanine32	7.2	RFC1, PCNA, BRCA1, VDR, MYC, RAD51
35	folate32	7.1	VIM, NAT2, BRCA1, BRCA2, VDR, MYC
36	vitamin d32	6.8	NCOR2, VIM, VDR, MTHFR, JUN, CDKN1A
37	estrogen32	6.7	NCOR2, PCNA, NAT2, BRCA1, BRCA2, VDR
38	pd 98,05932	6.6	PIK3CG, RB1, MYC, PARP1, ATF1, JUN
39	testosterone32 9 18 9	9.5	NCOR2, PCNA, RB1, VIM, BRCA1, BRCA2
40	resveratrol32 9 18 9	9.5	PIK3CG, PCNA, RB1, BRCA1, BRCA2, VEGFA
41	doxorubicin32 34 9 9	9.4	PIK3CG, NBN, VIM, BRCA1, PARP1, CHEK1
42	etoposide32 42 9 9	9.2	PIK3CG, PCNA, RB1, MYC, PARP1, CHEK1
43	butyrate32	6.0	PCNA, RB1, VIM, VDR, MYC, BCHE
44	thymidine32 18	6.9	PCNA, RB1, BRCA1, BRCA2, VDR, MYC
45	arsenite32 18	6.9	PIK3CG, PCNA, VEGFA, VDR, MYC, PARP1
46	vegf32	5.7	PIK3CG, PCNA, BRCA1, MYC, RAD51, PARP1
47	tamoxifen32 34 9 9	8.2	NCOR2, PCNA, VIM, BRCA1, BRCA2, VEGFA
48	paclitaxel32 34 9 9	7.7	PIK3CG, PCNA, RB1, VIM, BRCA1, BRCA2
49	retinoic acid32 42 18	6.6	PIK3CG, NCOR2, RB1, BRCA1, BRCA2, VDR
50	genistein32 9 18 9	7.6	PIK3CG, PCNA, RB1, VIM, BRCA1, BRCA2

Cellular components related to sporadic breast cancer according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	Fanconi anaemia nuclear complex	GO:043240	10.8	FANCG, FANCC, FANCF, FANCE, FANCA
2	chromosome, telomeric region	GO:000781	10.5	H2AFX, MRE11A, ATM, CHEK2, CHEK1, RAD17
3	Mre11 complex	GO:030870	10.4	NBN, RAD50, MRE11A
4	PML body	GO:016605	10.2	PML, PTEN, TP53, ATR, CHEK2, RAD51
5	transcription factor complex	GO:005667	9.8	EP300, SOX2, PRKDC, HIF1A, SRA1, JUN
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.7	HLA-DRB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
7	nuclear body	GO:016604	9.4	TP53, MDM2, CDKN2A, MYC, NCOR2
8	ER to Golgi transport vesicle membrane	GO:012507	9.4	HLA-DRB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
9	protein complex	GO:043234	9.3	PSEN2, STK11, NR3C1, TP53, MDM2, MEF2C
10	nucleolus	GO:005730	7.7	NFKB1, NOS3, NR3C1, TP53, HUS1, CCND2
11	nucleoplasm	GO:005654	6.5	CDK1, CHEK2, CHEK1, PARP1, LIG4, RAD1
12	cytoplasm	GO:005737	6.3	CTTN, NR3C1, NOS2, NOS3, PHB, NFKB1
13	cytosol	GO:005829	5.9	NOS3, NOS2, PLK1, NR3C1, PPARGC1A, CYP19A1
14	nucleus	GO:005634	5.0	EHMT2, EHF, WEE1, PGR, NMI, PMS1

Biological processes related to sporadic breast cancer according to GeneDecks:

(show top 50)    (show all 87)

id	Name	GO ID	Score	Top Affiliating Genes
1	double-strand break repair via homologous recombination	GO:000724	11.0	RAD51, NBN, BRCA1, MRE11A, BRCA2, ATM
2	DNA damage checkpoint	GO:000077	10.9	HUS1, H2AFX, CHEK1, CHEK2, ATRIP, ATR
3	DNA damage response, signal transduction resulting in induction of apoptosis	GO:008630	10.7	ATM, BRCA1, PML, ABL1, TP73, MSH6
4	response to ionizing radiation	GO:010212	10.6	BRCA1, ATM, STK11, H2AFX, CYP19A1, CYP17A1
5	response to UV	GO:009411	10.5	PML, MSH6, CDKN1A, CDKN2D, MAPK8, HUS1
6	positive regulation of protein autophosphorylation	GO:031954	10.5	NBN, RAP2A, VEGFA, RAD50, MRE11A
7	cellular response to ionizing radiation	GO:071479	10.5	TP53, HUS1, MGMT, CDKN1A, RAD1, GADD45A
8	double-strand break repair	GO:006302	10.4	TP53, MRE11A, ATM, XRCC6, CHEK2, LIG4
9	replicative senescence	GO:090399	10.3	CDKN2A, CDKN1A, ATM, ATR, CHEK2, CHEK1
10	DNA damage induced protein phosphorylation	GO:006975	10.3	CHEK1, CHEK2, ATM, ABL1
11	cell cycle checkpoint	GO:000075	10.3	WEE1, RAD1, RAD17, RBBP8, RB1, CHEK1
12	DNA repair	GO:006281	10.2	PRKDC, ATRIP, ATM, ATR, MSH6, MSH2
13	DNA replication	GO:006260	10.1	PCNA, CHEK1, RAD17, FHIT, RAD1, ATR
14	MyD88-independent toll-like receptor signaling pathway	GO:002756	10.0	NFKBIA, NFKB1, RPS6KA1, MAPK9, MAPK8, MEF2C
15	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.0	NFKB1, NFKBIA, RPS6KA1, MAPK9, ATF1, JUN
16	toll-like receptor 1 signaling pathway	GO:034130	10.0	NFKB1, MAPK9, RPS6KA1, MAPK8, MEF2C, CDK1
17	toll-like receptor 3 signaling pathway	GO:034138	10.0	ATF1, NFKBIA, JUN, CDK1, MEF2C, MAPK8
18	peptidyl-serine phosphorylation	GO:018105	10.0	TGFBR2, PRKDC, PLK1, MAPK8, AKT1, TGFBR1
19	toll-like receptor 2 signaling pathway	GO:034134	10.0	NFKB1, RPS6KA1, ATF1, MAPK8, MEF2C, CDK1
20	negative regulation of cell growth	GO:030308	10.0	TGFB1, PHB, TP53, ESR2, CDKN2A, CDKN2D
21	toll-like receptor signaling pathway	GO:002224	10.0	MAPK9, RPS6KA1, NFKB1, NFKBIA, MAPK8, MEF2C
22	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.0	NFKBIA, NFKB1, RPS6KA1, MAPK9, MAPK8, MEF2C
23	response to gamma radiation	GO:010332	10.0	PML, PRKDC, GPX1, CHEK2, LIG4, MYC
24	Toll signaling pathway	GO:008063	10.0	ATF1, NFKB1, CDK1, MEF2C, MAPK8, MAPK9
25	toll-like receptor 4 signaling pathway	GO:034142	9.9	ATF1, CDK1, NFKB1, NFKBIA, RPS6KA1, MAPK9
26	mismatch repair	GO:006298	9.9	MSH2, MSH6, TP73, PCNA, ABL1
27	telomere maintenance	GO:000723	9.8	RAD50, PRKDC, NBN, PARP1, RFC1, PCNA
28	transcription initiation from RNA polymerase II promoter	GO:006367	9.7	PARP1, MYC, VDR, NCOR2, GTF2F1, NR3C1
29	nerve growth factor receptor signaling pathway	GO:048011	9.6	MDM2, ATF1, MAPK8, AKT1, PTEN, RPS6KA1
30	interferon-gamma-mediated signaling pathway	GO:060333	9.6	HLA-DQA1, IFNG, HLA-A, HLA-B, HLA-DRB1, HLA-C
31	protein complex assembly	GO:006461	9.6	CDK1, PML, PPARGC1A, FANCC, FANCA, MDM2
32	release of cytochrome c from mitochondria	GO:001836	9.5	GPX1, SOD2, TP73, TP53, JUN, MYC
33	response to DNA damage stimulus	GO:006974	9.4	STK11, H2AFX, TP73, TP53, HUS1, CCND1
34	cell proliferation	GO:008283	9.4	MKI67, NBN, PCNA, LIG4, UHRF1, MRE11A
35	response to organic cyclic compound	GO:014070	9.4	CCND2, NOS3, CDKN1A, JUN, CDK1, ATF1
36	heart development	GO:007507	9.3	PCNA, ATM, EP300, PRKDC, TGFBR2, TGFBR1
37	negative regulation of cell proliferation	GO:008285	9.2	KAT2B, STK11, TGFB1, PHB, COL18A1, NOS3
38	virus-host interaction	GO:019048	9.2	EP300, TBP, TP53, HLA-C, HLA-B, HLA-A
39	positive regulation of gene expression	GO:010628	9.2	DNMT1, VDR, TGFB1, CDK1, MAPK9, MED1
40	organ regeneration	GO:031100	9.2	CDKN1A, CDK1, MKI67, MED1, CXCL12, CCND1
41	response to hypoxia	GO:001666	9.0	CXCL12, XRCC1, PML, ATM, VEGFA, ERCC2
42	apoptotic process	GO:006915	8.9	TGFBR1, TGFBR2, PRKDC, EP300, GADD45A, NBN
43	cell cycle arrest	GO:007050	8.9	MSH2, BARD1, RASSF1, MYC, NBN, RB1
44	transforming growth factor beta receptor signaling pathway	GO:007179	8.9	PML, TGFBR2, TGFBR1, PARP1, TP53, CCNC
45	positive regulation of protein phosphorylation	GO:001934	8.8	CD40, VEGFA, CCND2, CCND1, AKT1, ERBB2
46	negative regulation of apoptotic process	GO:043066	8.7	IGF1R, AKT1, ERCC2, TP53, PTEN, PLK1
47	positive regulation of transcription, DNA-dependent	GO:045893	8.5	BRCA1, JUN, CDKN2A, CDH1, GTF2F1, ING1
48	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.2	EP300, NCOR2, VDR, IFNG, MYC, PARP1
49	response to drug	GO:042493	7.6	MSH2, JUN, CDKN1A, NBN, MYC, BCHE
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	HDAC2, SOX2, PROX1, PRKDC, STAT1, TGFB1

Molecular functions related to sporadic breast cancer according to GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	damaged DNA binding	GO:003684	10.9	H2AFX, ERCC3, FANCG, APEX1, XRCC1, RAD1
2	ATP-dependent DNA helicase activity	GO:004003	10.7	ERCC3, ERCC2, MRE11A, XRCC6, RAD50, BRIP1
3	glutathione transferase activity	GO:004364	10.6	GSTZ1, GSTT1, GSTP1, GSTM3, GSTM1
4	single-stranded DNA specific endodeoxyribonuclease activity	GO:000014	10.4	RAD50, MRE11A
5	mismatched DNA binding	GO:030983	10.4	PMS1, MLH1, MSH6, MSH2
6	androgen receptor binding	GO:050681	10.4	EP300, NRIP1, PPARGC1A, GRIP1, BRCA1, RB1
7	transcription coactivator activity	GO:003713	10.3	CARM1, ESR2, SRA1, PPARGC1A, NRIP1, PML
8	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.2	CDKN2A, CDKN2D, CDKN1A, KAT2B
9	histone deacetylase binding	GO:042826	10.2	HIF1A, PHB, NRIP1, MAPK8, MEF2C, KAT2B
10	MutLalpha complex binding	GO:032405	10.2	ATR, MSH6, MSH2, PCNA
11	3-5 exonuclease activity	GO:008408	10.2	RAD50, RAD1, MRE11A, APEX1
12	protein C-terminus binding	GO:008022	9.9	ABL1, ERBB2, ERCC3, ERCC2, GRIP1, MKI67
13	transcription regulatory region DNA binding	GO:044212	9.8	PHB, NFKB1, HIF1A, PROX1, SOX2, TBP
14	protein N-terminus binding	GO:047485	9.8	TGFB1, TP53, ERCC3, ERCC2, ATM, YWHAQ
15	protein serine/threonine kinase activity	GO:004674	9.7	WEE1, PRKDC, STK11, TGFBR1, RPS6KA1, PLK1
16	protein kinase activity	GO:004672	9.5	PRKDC, TGFBR1, PLK1, ERCC3, ERCC2, AKT1
17	protein kinase binding	GO:019901	9.5	CCND1, TP53, TP73, PTEN, PLK1, HIF1A
18	double-stranded DNA binding	GO:003690	9.3	JUN, NR3C1, NFKB1, STAT1, MRE11A, MSH6
19	identical protein binding	GO:042802	9.0	AKT1, ESR1, ERBB2, TP53, TP73, NFKBIA
20	transcription factor binding	GO:008134	8.8	JUN, CDKN2A, GTF2A1, GTF2F1, MED1, MAPK9
21	protein homodimerization activity	GO:042803	8.8	NR3C1, NOS2, NFKB1, SHBG, ACHE, TGFB1
22	DNA binding	GO:003677	8.4	PPARGC1A, SRA1, TP53, ERCC3, ERCC2, ESR2
23	ATP binding	GO:005524	8.4	TP53, ERBB2, ERCC3, ERCC2, AKT1, IGF1R
24	sequence-specific DNA binding transcription factor activity	GO:003700	8.4	TP73, TBP, NR3C1, NFKB1, HIF1A, STAT1
25	enzyme binding	GO:019899	8.3	PTEN, NFKBIA, H2AFX, HIF1A, TGFB1, STAT1
26	protein heterodimerization activity	GO:046982	8.3	PML, TGFB1, HIF1A, NR3C1, TP53, ERBB2
27	protein binding	GO:005515	3.5	ESR1, COL18A1, PHB, NFKB1, NFKBIA, SHARPIN