MCID: SPR009
MIFTS: 31

Sporadic Breast Cancer malady

Cancer diseases category
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Summaries for Sporadic Breast Cancer

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33MalaCards
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MalaCards: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to breast cancer and breast cancer susceptibility. An important gene associated with Sporadic Breast Cancer is SLC35G6 (solute carrier family 35, member G6), and among its related pathways are p53 signaling pathway and DNA damage ATM ATR regulation of G1 S checkpoint. The compound mitomycin c have been mentioned in the context of this disorder. Affiliated tissues include breast and endothelial.

Aliases & Classifications for Sporadic Breast Cancer

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8Disease Ontology, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

sporadic breast cancer 8
sporadic breast carcinoma 62


External Ids:

Disease Ontology8 DOID:8029
NCIt40 C7566

Related Diseases for Sporadic Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.8FANCF, BRCA1, SCGB3A1
2breast cancer susceptibility10.3
3cowden disease10.1
4xeroderma pigmentosum10.1
5bilateral breast cancer10.1
6breast disease10.1
7ovarian cancer10.1
8familial breast cancer10.1
9mutagen sensitivity10.1
10hypoxia10.1
11endotheliitis10.1
12ataxia telangiectasia10.1BRCA1
13fanconi's anemia9.9FANCF, BRCA1

Graphical network of diseases related to Sporadic Breast Cancer:



Diseases related to sporadic breast cancer

Symptoms for Sporadic Breast Cancer

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Drugs & Therapeutics for Sporadic Breast Cancer

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Sporadic Breast Cancer

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

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Anatomical Context for Sporadic Breast Cancer

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33MalaCards
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MalaCards organs/tissues related to Sporadic Breast Cancer:

33
Breast, Endothelial

Animal Models for Sporadic Breast Cancer or affiliated genes

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Publications for Sporadic Breast Cancer

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52PubMed
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Articles related to Sporadic Breast Cancer:

(show top 50)    (show all 234)
idTitleAuthorsYear
1
HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women. (23976978)
2013
2
MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. (23860775)
2013
3
Imaging features of sporadic breast cancer in women under 40 years old: 97 cases. (23918218)
2013
4
Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. (23063927)
2013
5
Potential clinical significance of ERI^ ON promoter methylation in sporadic breast cancer. (23794253)
2013
6
Contralateral risk-reducing mastectomy in sporadic breast cancer. (23725708)
2013
7
The neurofibromin 1 type I isoform predominance characterises female population affected by sporadic breast cancer: preliminary data. (22412049)
2012
8
Quantification of PKC family genes in sporadic breast cancer by qRT-PCR: evidence that PKCI^/I> overexpression is an independent prognostic factor. (22511072)
2012
9
The TP53 gene polymorphisms and survival of sporadic breast cancer patients. (21365326)
2012
10
Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China. (21912605)
2011
11
Familial and sporadic breast cancers: differences in clinical, histopathological, and immunohistochemical features. (20308044)
2011
12
Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. (21113649)
2011
13
BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer. (20877436)
2010
14
Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor. (20043118)
2010
15
AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers. (21321378)
2010
16
Expression of FANCD2 in sporadic breast cancer and clinicopathological analysis. (20556575)
2010
17
A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (19937980)
2010
18
Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer. (20193849)
2010
19
Silencing of estrogen receptor alpha (ERalpha) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer. (18814026)
2009
20
Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (19765277)
2009
21
Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. (17952592)
2008
22
Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer. (18711133)
2008
23
Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. (18425370)
2008
24
Analysis of loss of heterozygosity and immunohistochemistry in BRCA1 gene in sporadic breast cancers. (16718381)
2006
25
FANCD2 associated with sporadic breast cancer risk. (16679306)
2006
26
Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. (17011986)
2006
27
A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk. (16103107)
2005
28
Sporadic breast cancer among relatives of BRCA mutation carriers. (16301869)
2005
29
Significant involvement of CCR2-64I and CXCL12-3a in the development of sporadic breast cancer. (15121787)
2004
30
BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. (15365993)
2004
31
The association of NAT2 polymorphisms with sporadic breast cancer]. (15285615)
2004
32
Alkaline single-cell gel electrophoresis (comet assay): a simple technique to show genomic instability in sporadic breast cancer. (14746864)
2004
33
A role for BRCA1 in sporadic breast cancer. (12698194)
2003
34
Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. (12888106)
2003
35
Clustering of variations and haplotype analysis in the highly variable region of exon 11 of BRCA1 in Chinese women with sporadic breast cancer. (12402341)
2002
36
Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. (12406554)
2002
37
Microsatellite instability correlates with negative expression of estrogen and progesterone receptors in sporadic breast cancer. (10992275)
2000
38
Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. (11071387)
2000
39
Association of A vitamin D receptor polymorphism with sporadic breast cancer development. (10597185)
1999
40
Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (10534407)
1999
41
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. (9537235)
1998
42
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. (9872332)
1998
43
Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient. (9665150)
1998
44
The genetics of sporadic breast cancer. (9108590)
1997
45
Microsatellite instability in early sporadic breast cancer. (8645585)
1996
46
Frequent allele loss on 9p21-22 defines a smallest common region in the vicinity of the CDKN2 gene in sporadic breast cancer. (8889502)
1996
47
Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer. (8616837)
1996
48
Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. (8589680)
1995
49
Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. (7795653)
1995
50
Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development. (8181852)
1994

Variations for Sporadic Breast Cancer

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Expression for genes affiliated with Sporadic Breast Cancer

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for genes affiliated with Sporadic Breast Cancer

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome
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Compounds for genes affiliated with Sporadic Breast Cancer

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45Novoseek
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Compounds related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mitomycin c459.9FANCF, BRCA1

GO Terms for genes affiliated with Sporadic Breast Cancer

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16Gene Ontology
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Biological processes related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:0062819.5FANCF, BRCA1, ATRIP
2negative regulation of cell growthGO:0303089.3SIPA1, SCGB3A1
3regulation of cell proliferationGO:0421279.1BRCA1, SCGB3A1

Products for genes affiliated with Sporadic Breast Cancer

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Sources for Sporadic Breast Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet