MCID: SPR009
MIFTS: 33

Sporadic Breast Cancer malady

Cancer diseases category

Summaries for Sporadic Breast Cancer

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32MalaCards
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MalaCards: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to breast cancer and breast disease. An important gene associated with Sporadic Breast Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Chks in Checkpoint Regulation and Fanconi Anemia pathway. Affiliated tissues include breast, colon and spleen.

Aliases & Classifications for Sporadic Breast Cancer

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

sporadic breast cancer 8
sporadic breast carcinoma 60


External Ids:

Disease Ontology8 DOID:8029
NCIt39 C7566

Related Diseases for Sporadic Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.9SCGB3A1, FANCF, BRCA1
2breast disease10.4
3retinoblastoma10.1
4estrogen-receptor negative breast cancer10.1
5progesterone-receptor negative breast cancer10.1
6xeroderma pigmentosum10.1
7cowden disease10.1
8bilateral breast cancer10.1
9chromosomal disease10.1
10ovarian cancer10.1

Graphical network of diseases related to Sporadic Breast Cancer:



Diseases related to sporadic breast cancer

Clinical Features for Sporadic Breast Cancer

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Drugs & Therapeutics for Sporadic Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sporadic Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Sporadic Breast Cancer

Search NIH Clinical Center for Sporadic Breast Cancer

Search CenterWatch for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

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Anatomical Context for Sporadic Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Sporadic Breast Cancer:

32
Breast, Colon, Spleen, Liver, Pancreas, Prostate, Testes, Endothelial

Animal Models for Sporadic Breast Cancer or affiliated genes

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Publications for Sporadic Breast Cancer

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50PubMed
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Articles related to Sporadic Breast Cancer:

(show top 50)    (show all 300)
idTitleAuthorsYear
1
Imaging features of sporadic breast cancer in women under 40 years old: 97 cases. (23918218)
2013
2
Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. (23063927)
2013
3
Investigation of CD28 gene polymorphisms in patients with sporadic breast cancer in a Chinese Han population in Northeast China. (23133541)
2012
4
Association of OX40L polymorphisms with sporadic breast cancer in northeast Chinese Han population. (22870213)
2012
5
BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls. (22402307)
2012
6
Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China. (21912605)
2011
7
Glycodelin expression associates with differential tumour phenotype and outcome in sporadic and familial non-BRCA1/2 breast cancer patients. (20676758)
2011
8
ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study. (21917182)
2011
9
A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (19937980)
2010
10
Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer. (20193849)
2010
11
Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (19765277)
2009
12
The CYP17 and CYP19 gene single nucleotide polymorphism in women with sporadic breast cancer. (20072949)
2009
13
Gene and chromosomal alterations in sporadic breast cancer: correlation with histopathological features and implications for genesis and progression. (19472036)
2009
14
Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. (17952592)
2008
15
BRCA1 mutations in Algerian breast cancer patients: high frequency in young, sporadic cases. (18645608)
2008
16
Methylation status of CpG islands at sites -59 to +96 in exon 1 of the BRCA2 gene varies in mammary tissue among women with sporadic breast cancer. (18776644)
2008
17
Association of cytokine gene polymorphisms with cachexia related to sporadic female breast cancer]. (18953879)
2008
18
Copy number alterations of the H2AFX gene in sporadic breast cancer patients. (18206537)
2008
19
Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. (18647968)
2008
20
Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations. (18058223)
2008
21
Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol. (17697367)
2007
22
Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg>Pro polymorphism. (17945002)
2007
23
Expression of estrogen receptor beta wt isoform (ERbeta1) and ERbetaDelta5 splice variant mRNAs in sporadic breast cancer. (17457609)
2007
24
Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1- and non-BRCA1/2 families as compared to sporadic breast cancer cases. (17307353)
2007
25
Identification of novel alternatively spliced BRCA1-associated RING domain (BARD1) messenger RNAs in human peripheral blood lymphocytes and in sporadic breast cancer tissues. (17497650)
2007
26
A mutation in the 5' untranslated region of the BRCA1 gene in sporadic breast cancer causes downregulation of translation efficiency. (17697535)
2007
27
Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. (17011986)
2006
28
Distinction between hereditary and sporadic breast cancer on the basis of clinicopathological data. (16603649)
2006
29
The estrogen receptor alpha C975G variant in familial and sporadic breast cancer: a case-control study. (16886637)
2006
30
Allelic imbalance of HER2 variant in sporadic breast and ovarian cancer. (16682283)
2006
31
Carcinogen-induced DNA double strand break repair in sporadic breast cancer. (16650867)
2006
32
Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue. (16187283)
2006
33
Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer. (15743496)
2005
34
Loss of heterozygosity at the BRCA1 locus in Tunisian women with sporadic breast cancer. (15914269)
2005
35
Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast. (15644556)
2005
36
Allele imbalance, or loss of heterozygosity, in normal breast epithelium of sporadic breast cancer cases and BRCA1 gene mutation carriers is increased compared with reduction mammoplasty tissues. (16314623)
2005
37
Aberrations of breast cancer susceptibility genes occur early in sporadic breast tumors and in acquisition of breast epithelial immortalization. (15334544)
2004
38
Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. (12888106)
2003
39
Regulation of BRCA1 expression and its relationship to sporadic breast cancer. (12559046)
2003
40
Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. (12406554)
2002
41
Detailed deletion mapping in sporadic breast cancer at chromosomal region 17p13 distal to the TP53 gene: association with clinicopathological parameters. (11439364)
2001
42
Association between loss of heterozygosity of BRCA1 and BRCA2 and morphological attributes of sporadic breast cancer. (11004669)
2000
43
Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines. (10717253)
2000
44
Refined deletion mapping in sporadic breast cancer at chromosomal region 8p12-p21 and association with clinicopathological parameters. (10930798)
2000
45
Analyses of microsatellite instability and the transforming growth factor-beta receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features. (10206070)
1999
46
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. (9872332)
1998
47
Frequent loss of heterozygosity at chromosome 13q12-13 with BRCA2 markers in sporadic male breast cancer. (9646036)
1998
48
Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers. (9639385)
1998
49
Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands. (9288768)
1997
50
Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer. (8932343)
1996

Genetic Variations for Sporadic Breast Cancer

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Expression for genes affiliated with Sporadic Breast Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for genes affiliated with Sporadic Breast Cancer

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7HUS1, FANCF, BRCA1
2
Hide members
10.6FANCF, BRCA1
310.6HUS1, BRCA1

Compounds for genes affiliated with Sporadic Breast Cancer

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GO Terms for genes affiliated with Sporadic Breast Cancer

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16Gene Ontology
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Biological processes related to Sporadic Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to UVGO:00941110.6HUS1, CDKN2D

Products for genes affiliated with Sporadic Breast Cancer

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Sources for Sporadic Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet