MCID: SPR009
MIFTS: 47

Sporadic Breast Cancer malady

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Sporadic Breast Cancer

Aliases & Descriptions for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 12 14
Sporadic Breast Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8029
NCIt 47 C7566
UMLS 69 C1336076

Summaries for Sporadic Breast Cancer

MalaCards based summary : Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to breast cancer and aorto-ventricular tunnel. An important gene associated with Sporadic Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are Gene Expression and Cell Cycle, Mitotic. The drugs Paclitaxel and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include breast and endothelial, and related phenotypes are Decreased homologous recombination repair frequency and cellular

Related Diseases for Sporadic Breast Cancer

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ
Familial Breast Cancer Bard1-Related Susceptibility to Breast Cancer
Brip1-Related Breast Cancer Chek2-Related Susceptibility to Breast Cancer
Rad51-Related Susceptibility to Breast Cancer

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
id Related Disease Score Top Affiliating Genes
1 breast cancer 10.8
2 aorto-ventricular tunnel 10.4 BRCA1 BRCA2
3 bartholin's gland benign neoplasm 10.3 ESR1 PGR
4 bladder clear cell adenocarcinoma 10.3 ESR1 TP53
5 burn scar 10.3 BRCA1 BRCA2
6 aortitis 10.3 PGR TP53
7 cardiovascular organ benign neoplasm 10.3 ESR1 PGR
8 mouth disease 10.3 ERBB2 PGR
9 appendix leiomyoma 10.3 ESR1 PGR
10 bronchus adenoma 10.3 ESR1 PGR
11 ovarian benign neoplasm 10.3 ESR1 PGR
12 plexiform neurofibroma 10.3 ESR1 PGR
13 lethal congenital contracture syndrome 7 10.3 BRCA1 BRCA2
14 autoimmune disease of cardiovascular system 10.3 BRCA1 BRCA2 PGR
15 heart malignant hemangiopericytoma 10.3 BRCA1 BRCA2 PGR
16 mediastinum synovial sarcoma 10.3 BRCA1 BRCA2 TP53
17 cellular ependymoma 10.3 BRCA1 BRCA2 TP53
18 benign breast phyllodes tumor 10.3 PGR PTEN
19 kunjin encephalitis 10.3 BRCA1 BRCA2 ERBB2
20 pneumonia 10.3 BRCA1 BRCA2 PGR
21 deafness, autosomal recessive 21 10.2 ESR1 ESR2 PGR
22 nemaline myopathy 8, autosomal recessive 10.2 BRCA1 BRCA2 ERBB2
23 paranasal sinus disease 10.2 ESR1 PGR
24 vaginal adenosarcoma 10.2 ESR1 PGR TP53
25 intraorbital meningioma 10.2 ATM BRCA1 TP53
26 osteogenesis imperfecta 10.2 ESR1 ESR2 PGR
27 acute thyroiditis 10.2 ESR1 ESR2 PGR
28 perinatal jaundice due to hepatocellular damage 10.2 ESR1 ESR2 PGR
29 deafness, autosomal recessive 74 10.2 ESR1 ESR2 PGR
30 glioma 10.2 ERBB2 ESR1 PGR
31 pericardium leiomyoma 10.2 PGR TP53
32 cervical lymphoepithelioma-like carcinoma 10.2 ERBB2 ESR1 PGR
33 nervous system hibernoma 10.2 ERBB2 ESR1 PGR
34 substance abuse 10.2 ERBB2 ESR1 ESR2
35 poliomyelitis 10.2 ERBB2 ESR1 PGR
36 rectal neoplasm 10.2 ERBB2 ESR1 PGR
37 combined t cell and b cell immunodeficiency 10.2 ERBB2 ESR1 PGR
38 anomalous left coronary artery from the pulmonary artery 10.2 ERBB2 ESR1 PGR
39 peeling skin syndrome 10.2 ESR1 ESR2 PGR
40 gallbladder papillomatosis 10.2 ESR2 PGR TP53
41 anus adenocarcinoma 10.2 ERBB2 ESR1 PGR
42 sclerosing hemangioma 10.2 ERBB2 ESR1 PGR
43 t-cell adult acute lymphocytic leukemia 10.2 ERBB2 ESR1 PGR
44 retinal disease 10.2 ERBB2 ESR1 PGR
45 kidney benign neoplasm 10.2 ESR2 PGR TP53
46 her2-receptor positive breast cancer 10.2 ERBB2 ESR1 PGR
47 fallopian tube adenocarcinoma 10.2 ERBB2 ESR1 TP53
48 breast ductal carcinoma 10.2 PGR PTEN TP53
49 childhood teratocarcinoma of the testis 10.2 BRCA1 BRCA2 PTEN
50 breast duct papilloma 10.2 ERBB2 ESR1 PGR

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer

Symptoms & Phenotypes for Sporadic Breast Cancer

GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.67 BARD1 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.67 RAD51 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.67 BARD1 BRCA1 BRCA2 RAD51 PGR
4 Decreased homologous recombination repair frequency GR00236-A-2 10.67 BARD1 BRCA1 RAD51 ATM BRCA2 PGR
5 Decreased homologous recombination repair frequency GR00236-A-3 10.67 BARD1 BRCA2 RAD51 BRCA1
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 ATM BARD1 BRCA1 BRCA2 CHEK2 PTEN
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 ATM BARD1 BRCA1 BRCA2 CHEK2 PTEN
8 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.76 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
9 Increased cell death HMECs cells GR00103-A-0 9.73 BRCA1 PGR PTEN RAD51 TP53 TTC4
10 Decreased viability with cisplatin GR00101-A-4 9.62 BRCA2 RAD51 BARD1 BRCA1
11 Decreased viability after ionizing radiation GR00232-A-2 9.54 ATM BRCA1 BRCA2
12 Synthetic lethal with cisplatin GR00101-A-1 9.26 RAD51 BARD1 BRCA1 BRCA2

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 PGR PTEN RAD51 TP53 XRCC1 ATM
2 behavior/neurological MP:0005386 10.24 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
3 embryo MP:0005380 10.24 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
4 growth/size/body region MP:0005378 10.2 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
5 endocrine/exocrine gland MP:0005379 10.18 ATM BRCA1 ESR1 ESR2 PGR PTEN
6 mortality/aging MP:0010768 10.18 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
7 integument MP:0010771 10.09 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
8 digestive/alimentary MP:0005381 10.05 BRCA1 BRCA2 ERBB2 ESR1 ESR2 PTEN
9 neoplasm MP:0002006 10.03 BRCA2 CHEK2 ERBB2 ESR1 ESR2 PGR
10 adipose tissue MP:0005375 10.02 ATM BRCA1 ESR1 ESR2 PTEN TP53
11 limbs/digits/tail MP:0005371 10.01 BRCA1 BRCA2 ERBB2 ESR1 ESR2 PGR
12 nervous system MP:0003631 9.9 BARD1 BRCA1 BRCA2 CHEK2 ERBB2 ESR1
13 muscle MP:0005369 9.87 PGR PTEN TP53 BRCA1 ERBB2 ESR1
14 normal MP:0002873 9.65 BARD1 BRCA1 BRCA2 ERBB2 ESR1 ESR2
15 reproductive system MP:0005389 9.28 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2

Drugs & Therapeutics for Sporadic Breast Cancer

Drugs for Sporadic Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
3 Albumin-Bound Paclitaxel Phase 2
4 Analgesics Phase 2
5 Anti-Anxiety Agents Phase 2
6 Anticonvulsants Phase 2
7 Antimitotic Agents Phase 2
8 Antineoplastic Agents, Phytogenic Phase 2
9 calcium channel blockers Phase 2
10 Calcium, Dietary Phase 2
11 Central Nervous System Depressants Phase 2
12 Peripheral Nervous System Agents Phase 2
13 Psychotropic Drugs Phase 2
14 Tranquilizing Agents Phase 2
15
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
16
Olaparib Approved Phase 1 763113-22-0 23725625
17 Poly(ADP-ribose) Polymerase Inhibitors Phase 1
18
Lapatinib Approved March 2007, Investigational Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
19 Protein Kinase Inhibitors Early Phase 1
20 Hypoglycemic Agents
21 insulin
22 Insulin, Globin Zinc

Interventional clinical trials:


id Name Status NCT ID Phase
1 Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia Unknown status NCT02024568 Phase 2
2 A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer Completed NCT00600275 Phase 1, Phase 2
3 AZD2281 Plus Carboplatin to Treat Breast and Ovarian Cancer Active, not recruiting NCT01445418 Phase 1
4 Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer Unknown status NCT01172886
5 Concentration and Activity of Lapatinib in Vestibular Schwannomas Unknown status NCT00863122 Early Phase 1
6 Insulin Resistance and Breast Cancer Completed NCT00304941
7 Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation Recruiting NCT02664389
8 Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers Active, not recruiting NCT02087592

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

MalaCards organs/tissues related to Sporadic Breast Cancer:

39
Breast, Endothelial

Publications for Sporadic Breast Cancer

Articles related to Sporadic Breast Cancer:

(show top 50) (show all 275)
id Title Authors Year
1
Simultaneous ATM/BRCA1/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients. ( 28058614 )
2017
2
Variants of estrogen receptor alpha and beta genes modify the severity of sporadic breast cancer. ( 28109853 )
2017
3
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility. ( 26650628 )
2016
4
Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1. ( 27039925 )
2016
5
Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer. ( 26723934 )
2016
6
Association between genetic variants of EGF-containing fibulin-like extracellular matrix protein1 gene and sporadic breast cancer in a Chinese Han population. ( 27048115 )
2016
7
RECQL4 helicase has oncogenic potential in sporadic breast cancers. ( 26690729 )
2016
8
Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients. ( 26205471 )
2016
9
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. ( 26754093 )
2016
10
Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards. ( 27189832 )
2016
11
Twenty-one-gene recurrence score assay in BRCA-associated versus sporadic breast cancers: Differences based on germline mutation status. ( 26859126 )
2016
12
A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility. ( 27668787 )
2016
13
Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. ( 27413552 )
2016
14
First description of a sporadic breast cancer in a woman with BRCA1 germline mutation. ( 26426992 )
2015
15
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women. ( 26598080 )
2015
16
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer. ( 26430163 )
2015
17
Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China. ( 26535628 )
2015
18
The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population. ( 25674498 )
2015
19
Decreased Expression of BRCA2 Accelerates Sporadic Breast Cancer Progression. ( 27065665 )
2015
20
Development and validation of molecular methodologies to assess PALB2 expression in sporadic breast cancer. ( 26526077 )
2015
21
Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study. ( 26476291 )
2015
22
ATM gene mutations in sporadic breast cancer patients from Brazil. ( 25625042 )
2015
23
Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies. ( 26643130 )
2015
24
DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China. ( 25961110 )
2015
25
Assessing Heavy Metal and PCB Exposure from Tap Water by Measuring Levels in Plasma from Sporadic Breast Cancer Patients, a Pilot Study. ( 26690196 )
2015
26
Promoter methylation and expression changes of BRCA1 in cancerous tissues of patients with sporadic breast cancer. ( 25789047 )
2015
27
Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. ( 26456802 )
2015
28
A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer. ( 26320393 )
2015
29
The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients. ( 24850984 )
2014
30
BRCA1 gene exon 11 mutations in Uighur and Han women with early-onset sporadic breast cancer in the northwest region of China. ( 24969878 )
2014
31
A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. ( 25067956 )
2014
32
Association of +405C>G and +936C>T polymorphisms of the vascular endothelial growth factor gene with sporadic breast cancer in North Indians. ( 24528036 )
2014
33
Association of TNF-I+, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women. ( 25010932 )
2014
34
Association of promoter methylation of ERI+ and ERI^ with sporadic breast cancer--a study from North India. ( 24833090 )
2014
35
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. ( 24556691 )
2014
36
Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers. ( 25342642 )
2014
37
Combined microRNA and ER expression: a new classifier for familial and sporadic breast cancer patients. ( 25406994 )
2014
38
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts. ( 25425972 )
2014
39
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis. ( 24464625 )
2014
40
The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer. ( 24842653 )
2014
41
Association of BRCA1 promoter methylation with rs11655505 (c.2265C>T) variants and decreased gene expression in sporadic breast cancer. ( 23263908 )
2013
42
MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. ( 23860775 )
2013
43
Potential clinical significance of ERI^ ON promoter methylation in sporadic breast cancer. ( 23794253 )
2013
44
HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women. ( 23976978 )
2013
45
Contralateral risk-reducing mastectomy in sporadic breast cancer. ( 23725708 )
2013
46
Imaging features of sporadic breast cancer in women under 40 years old: 97 cases. ( 23918218 )
2013
47
Genetic variant rs16430 6bpa88>a880bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-hispanic white women aged a8o55a88years. ( 24166930 )
2013
48
Loss of WIF-1 and Wnt5a expression is related to aggressiveness of sporadic breast cancer in Tunisian patients. ( 23417837 )
2013
49
Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. ( 23063927 )
2013
50
Clinical implications of ERI^ methylation on sporadic breast cancers in Chinese women. ( 22105146 )
2012

Variations for Sporadic Breast Cancer

Expression for Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for Sporadic Breast Cancer

Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 46)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 ATM BARD1 BRCA1 CHEK2 ERBB2 ESR1
2
Show member pathways
13.4 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
3
Show member pathways
13.18 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
12.97 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
5
Show member pathways
12.95 ATM BARD1 BRCA1 CHEK2 PTEN TP53
6
Show member pathways
12.88 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
7
Show member pathways
12.8 BARD1 BRCA1 ESR1 PTEN TP53
8 12.66 BRCA2 ERBB2 PTEN RAD51 TP53
9
Show member pathways
12.62 ATM BARD1 BRCA1 CHEK2 TP53
10 12.49 ATM BRCA1 ERBB2 PTEN TP53
11 12.49 ATM BRCA1 BRCA2 CHEK2 RAD51 TP53
12
Show member pathways
12.46 ATM BRCA1 BRCA2 RAD51
13
Show member pathways
12.45 ERBB2 ESR1 ESR2 PTEN
14
Show member pathways
12.41 ATM CHEK2 ERBB2 TP53
15
Show member pathways
12.35 ATM BARD1 BRCA1 CHEK2 TP53
16
Show member pathways
12.35 ATM BRCA1 CHEK2 PTEN RAD51 TP53
17
Show member pathways
12.26 ATM BARD1 BRCA1 BRCA2 RAD51
18
Show member pathways
12.26 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
19
Show member pathways
12.22 ATM BRCA1 CHEK2 PTEN TP53
20
Show member pathways
12.21 BRCA1 CHEK2 ESR1 PGR
21
Show member pathways
12.12 ATM BARD1 BRCA1 BRCA2 RAD51
22
Show member pathways
12.08 BRCA2 ERBB2 RAD51 TP53
23 12.06 ATM CHEK2 PTEN TP53
24 11.96 ATM ERBB2 PTEN TP53
25 11.84 BRCA1 BRCA2 RAD51
26
Show member pathways
11.83 ATM BRCA1 CHEK2 RAD51 TP53
27
Show member pathways
11.82 ESR1 ESR2 PGR
28 11.72 ATM BRCA1 XRCC1
29
Show member pathways
11.72 ATM CHEK2 TP53
30 11.71 ATM BRCA1 ERBB2 GSTM1 GSTT1 TP53
31 11.66 ERBB2 PTEN TP53
32 11.62 ATM CHEK2 TP53
33 11.62 ATM BRCA1 CHEK2 ERBB2 PTEN TP53
34
Show member pathways
11.62 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
35
Show member pathways
11.47 ATM CHEK2 TP53
36 11.47 ATM BARD1 BRCA1 CHEK2 TP53
37 11.46 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
38 11.4 ATM BARD1 BRCA1 CHEK2 PTEN TP53
39 11.39 BRCA2 CHEK2 ESR1 XRCC1
40 11.37 ESR1 PTEN TP53
41 11.29 ATM BRCA1 TP53
42 11.29 ATM ESR2 PGR
43 11.26 ATM BARD1 BRCA1 RAD51 TP53
44 11.04 ATM BRCA1 TP53
45 10.35 CHEK2 TP53
46 10.24 ESR1 ESR2

GO Terms for Sporadic Breast Cancer

Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 9.62 ATM BRCA2 RAD51 XRCC1
2 PML body GO:0016605 9.46 CHEK2 PTEN RAD51 TP53
3 nucleoplasm GO:0005654 9.44 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
4 BRCA1-A complex GO:0070531 9.4 BARD1 BRCA1
5 BRCA1-BARD1 complex GO:0031436 9.26 BARD1 BRCA1
6 lateral element GO:0000800 9.13 BRCA1 BRCA2 RAD51
7 nucleus GO:0005634 10.21 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 protein deubiquitination GO:0016579 9.97 BARD1 BRCA1 ESR1 PTEN TP53
2 regulation of apoptotic process GO:0042981 9.93 ATM BRCA1 CHEK2 ESR1 TP53
3 DNA repair GO:0006281 9.86 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
4 regulation of signal transduction by p53 class mediator GO:1901796 9.83 ATM BARD1 BRCA1 CHEK2 TP53
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.81 ESR1 ESR2 PTEN
6 double-strand break repair GO:0006302 9.8 BRCA1 BRCA2 CHEK2
7 double-strand break repair via nonhomologous end joining GO:0006303 9.8 ATM BARD1 BRCA1 XRCC1
8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.79 ATM CHEK2 TP53
9 steroid hormone mediated signaling pathway GO:0043401 9.77 ESR1 ESR2 PGR
10 double-strand break repair via homologous recombination GO:0000724 9.77 ATM BRCA1 BRCA2 RAD51 XRCC1
11 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.76 ATM BRCA1 BRCA2 CHEK2
12 response to gamma radiation GO:0010332 9.75 BRCA2 CHEK2 TP53
13 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.73 BRCA2 CHEK2 TP53
14 cellular response to gamma radiation GO:0071480 9.71 ATM CHEK2 RAD51 TP53
15 response to X-ray GO:0010165 9.7 BRCA2 RAD51 TP53
16 DNA double-strand break processing GO:0000729 9.69 ATM BARD1 BRCA1
17 replicative senescence GO:0090399 9.65 ATM CHEK2 TP53
18 determination of adult lifespan GO:0008340 9.63 ATM TP53
19 DNA damage induced protein phosphorylation GO:0006975 9.62 ATM CHEK2
20 protein K6-linked ubiquitination GO:0085020 9.62 BARD1 BRCA1
21 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.62 BRCA1 BRCA2 CHEK2 TP53
22 chromosome organization involved in meiotic cell cycle GO:0070192 9.61 ATM RAD51
23 cellular response to DNA damage stimulus GO:0006974 9.61 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
24 chordate embryonic development GO:0043009 9.59 BRCA1 BRCA2
25 mitotic recombination-dependent replication fork processing GO:1990426 9.55 BRCA2 RAD51
26 DNA synthesis involved in DNA repair GO:0000731 9.55 ATM BARD1 BRCA1 BRCA2 RAD51
27 strand displacement GO:0000732 9.02 ATM BARD1 BRCA1 BRCA2 RAD51
28 positive regulation of transcription, DNA-templated GO:0045893 10.06 BRCA1 BRCA2 CHEK2 ESR1 ESR2 TP53

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.97 CHEK2 ERBB2 ESR1 PTEN RAD51 TP53
2 lipid binding GO:0008289 9.81 ESR1 ESR2 PGR PTEN
3 damaged DNA binding GO:0003684 9.63 BRCA1 TP53 XRCC1
4 steroid hormone receptor activity GO:0003707 9.61 ESR1 ESR2 PGR
5 core promoter sequence-specific DNA binding GO:0001046 9.54 ESR1 ESR2 TP53
6 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.43 ESR1 ESR2 PGR
7 estrogen receptor activity GO:0030284 9.4 ESR1 ESR2
8 steroid binding GO:0005496 9.33 ESR1 ESR2 PGR
9 estrogen response element binding GO:0034056 9.32 ESR1 ESR2
10 enzyme binding GO:0019899 9.23 BRCA1 ESR1 ESR2 GSTM1 PGR PTEN
11 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
12 protein binding GO:0005515 10.38 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY

Sources for Sporadic Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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