MCID: SPR010
MIFTS: 52

Sporotrichosis malady

Rare diseases, Infectious diseases categories
Download this MalaCard

Summaries for Sporotrichosis

About this section
Sources:
8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A primary systemic mycosis that results in a systemic fungal infection, has material basis in sporothrix schenckii in animals and humans and results in formation of red papule at the site of inoculation.

MalaCards: Sporotrichosis, also known as sporotrichosis, unspecified, is related to syphilis and leukemia. An important gene associated with Sporotrichosis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are B Cell Receptor Signaling Pathway and Primary immunodeficiency. The drugs itraconazole and potassium iodide and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

CDC:4 The page you requested has been moved. Please update your links and bookmarks to the new Sporotrichosis web page.

Wikipedia:65 Sporotrichosis (also known as \"Rose gardener\'s disease\") is a disease caused by the infection of the... more...

Aliases & Classifications for Sporotrichosis

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
sporotrichosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of death: Normal


Aliases & Descriptions:

sporotrichosis 8 43 10 49 62
sporotrichosis, unspecified 8
rose gardener's disease 43
sporotrichosis nos 8


External Ids:

Disease Ontology8 DOID:14484
MeSH35 D013174
ICD9CM27 117.1
MESH via Orphanet36 D013174
ICD10 via Orphanet26 B42.0, B42.1, B42.7 B42.8, B42.9, more
SNOMED-CT via Orphanet59 42094007
UMLS via Orphanet63 C0038034
ICD1025 B42, B42.9

Related Diseases for Sporotrichosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis30.2CD79A
2leukemia30.0ITGAX, CD79A, CD40LG
3lupus erythematosus29.9CD40LG, CD79A
4arthritis10.3
5chromoblastomycosis10.2
6pyoderma gangrenosum10.2
7meningitis10.2
8pyoderma10.2
9acquired immunodeficiency syndrome10.2
10laryngitis10.2
11leishmaniasis10.2
12tuberculosis10.2
13mycetoma10.2
14rosacea10.1
15lepromatous leprosy10.1
16lymphangitis10.1
17secondary syphilis10.1
18blastomycosis10.1
19gout10.1
20hairy cell leukemia10.1
21histoplasmosis10.1
22keratoacanthoma10.1
23leprosy10.1
24osteomyelitis10.1
25sarcoidosis10.1
26sarcoma10.1
27q fever10.1CD79A
28macroglobulinemia10.1CD79A
29cryptosporidiosis10.1CD79A
30congenital toxoplasmosis10.0CD40LG, CD79A
31immunoglobulin g deficiency10.0CD40LG, CD79A
32selective iga deficiency disease10.0CD79A, CD40LG
33immunodeficiency, centromere instability and facial anomalies syndrome10.0CD40LG, CD79A
34immunoglobulin alpha deficiency10.0CD40LG, CD79A
35immunodeficiency with hyper igm type 110.0CD79A, CD40LG
36cryoglobulinemia10.0CD40LG, CD79A
37rubella10.0CD40LG, CD79A
38autoimmune hemolytic anemia10.0CD79A, CD40LG
39infectious mononucleosis10.0CD79A, CD40LG
40toxoplasmosis10.0CD40LG, CD79A
41agammaglobulinemia10.0CD79A, CD40LG
42immunodeficiency, common variable, 710.0CD79A, CD40LG
43common variable immune deficiency10.0CD40LG, CD79A
44ankylosing spondylitis10.0CD79A, CD40LG
45antiphospholipid syndrome10.0CD79A, CD40LG
46measles10.0CD40LG, CD79A
47schistosomiasis10.0CD40LG, CD79A
48polyneuropathy10.0CD79A, CD40LG
49lupus nephritis10.0CD40LG, CD79A
50iga glomerulonephritis10.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to sporotrichosis

Symptoms for Sporotrichosis

About this section

Drugs & Therapeutics for Sporotrichosis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Sporotrichosis

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Sporotrichosis

About this section

Anatomical Context for Sporotrichosis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Sporotrichosis:

33
Skin, Bone, Lung, Brain, Liver, Breast, Testes, Monocytes

Animal Models for Sporotrichosis or affiliated genes

About this section

Publications for Sporotrichosis

About this section
Sources:
52PubMed
See all sources

Articles related to Sporotrichosis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study. (24328608)
2014
2
Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes. (23286352)
2013
3
A survey of 165 sporotrichosis cases examined in Nagasaki prefecture from 1951 to 2012. (24283850)
2013
4
Treatment abandonment in feline sporotrichosis - study of 147 cases. (22898261)
2013
5
Cutaneous disseminated sporotrichosis complicated by osteomyelitis. (22855250)
2013
6
Therapeutic monoclonal antibody for sporotrichosis. (23226146)
2012
7
Unusual clinical presentation of sporotrichosis in three members of one family. (22435433)
2012
8
Sporotrichosis in pregnancy: case reports of 5 patients in a zoonotic epidemic in Rio de Janeiro, Brazil. (22147042)
2011
9
Response to azolic antifungal agents for treating feline sporotrichosis. (20208075)
2010
10
Use of local hyperthermia to treat sporotrichosis in a cat. (20154314)
2010
11
Oral potassium iodide for the treatment of sporotrichosis. (19821356)
2009
12
Histopathology of canine sporotrichosis: a morphological study of 86 cases from Rio de Janeiro (2001-2007). (19360480)
2009
13
Asteroid body in sporotrichosis. Yeast viability and biological significance within the host immune response. (18608903)
2008
14
Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis. (18991286)
2008
15
Sporotrichosis in Mysore: a case report to emphasize the role of histopathology. (18417852)
2008
16
Immunoglobulins G, M, and A against Sporothrix schenckii exoantigens in patients with sporotrichosis before and during treatment with itraconazole. (17634504)
2007
17
Sporotrichosis: success of itraconazole treatment. (17215622)
2007
18
Extracutaneous sporotrichosis in a patient with liver cirrhosis. (17592891)
2007
19
Cytologic diagnosis of generalized cutaneous sporotrichosis in a hunting hound. (17311202)
2007
20
Emergence of sporotrichosis in Manipur. (16912444)
2006
21
Fatal sporotrichosis. (17121061)
2006
22
Localized cutaneous sporotrichosis in a child. (17043206)
2006
23
Humoral immune response against soluble and fractionate antigens in experimental sporotrichosis. (15681154)
2005
24
Laryngeal sporotrichosis mimicking merkel cell carcinoma recurrence. (15692552)
2005
25
Importance of the direct fresh examination in the diagnosis of cutaneous sporotrichosis. (15533061)
2004
26
Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998-2001). (15154732)
2004
27
Sporotrichosis with widespread cutaneous lesions: report of 24 cases related to transmission by domestic cats in Rio de Janeiro, Brazil. (12956676)
2003
28
Haematogenous spread of Sporothrix schenckii in cats with naturally acquired sporotrichosis. (14510328)
2003
29
Phenotyping and genotyping of Sporothrix schenckii isolates according to geographic origin and clinical form of Sporotrichosis. (12149366)
2002
30
A case of cutaneous disseminated sporotrichosis. (11320714)
2001
31
A case of lymphocutaneous sporotrichosis]. (11479537)
2001
32
MR imaging appearance of cutaneous sporotrichosis. (10350324)
1999
33
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
34
The asteroid bodies of sporotrichosis. (9650696)
1998
35
Neck skin sporotrichosis after electrolysis. (9462788)
1998
36
Sporotrichosis: a case report and successful treatment with itraconazole. (9283771)
1997
37
Sporotrichosis: nasal obstruction in an infant. (8801823)
1996
38
Successful treatment of cutaneous sporotrichosis with liquid nitrogen: report of three cases. (8559191)
1995
39
Fatal pulmonary sporotrichosis caused by Sporothrix schenckii var. luriei in India. (1401023)
1992
40
Sporotrichosis in human immunodeficiency virus-infected patients: report of a case. (1962081)
1991
41
Feline sporotrichosis: an increasingly important zoonotic disease in Malaysia. (2270639)
1990
42
A familial occurrence of sporotrichosis. (2365904)
1990
43
Sporotrichosis in the Orinoco river basin of Venezuela and Colombia. (2739691)
1989
44
Multistate outbreak of sporotrichosis in seedling handlers, 1988. (2971870)
1988
45
Abnormal bone and gallium scans in a case of multifocal systemic sporotrichosis. (3769363)
1986
46
Sporotrichosis in India: first authentic case report from the north-western region and a critical literature review. (3746583)
1986
47
Articular sporotrichosis. (3956012)
1986
48
Fixed cutaneous sporotrichosis: unusual histopathology following intralesional corticosteroid administration. (4008700)
1985
49
Sporotrichosis research in the Transvaal--how it began 60 years ago. (3892731)
1985
50
Tropical fish aquariums. A source of Mycobacterium marinum infections resembling sporotrichosis. (5466918)
1970

Variations for Sporotrichosis

About this section

Expression for genes affiliated with Sporotrichosis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for genes affiliated with Sporotrichosis

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Sporotrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.3CD40LG, CD79A
29.3CD40LG, CD79A

Compounds for genes affiliated with Sporotrichosis

About this section
Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience
See all sources

Compounds related to Sporotrichosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1sulfolipid i459.8CD40LG, CD79A
2sandoglobulin459.8CD40LG, CD79A
3gamma globulin459.8CD40LG, CD79A
4vancomycin45 1110.8CD79A, CD40LG
5pneumococcal459.8CD40LG, CD79A
6blys459.8CD40LG, CD79A
7tuberculin459.8CD40LG, CD79A
8praziquantel45 1110.8CD40LG, CD79A
9hemocyanin459.8CD79A, CD40LG
10gliadin459.8CD40LG, CD79A
11pmma459.8CD79A, CD40LG
12silicone459.8CD40LG, CD79A
13mannan459.7CD40LG, CD79A
14okt3459.7CD79A, CD40LG
15glutaraldehyde459.7CD40LG, CD79A
16sulfasalazine29 45 51 1112.7CD40LG, CD79A
17cardiolipin45 1110.7CD79A, CD40LG
18valproate459.7CD40LG, CD79A
19mycophenolate mofetil45 51 1111.7CD79A, CD40LG
20phenytoin45 51 29 1112.7CD40LG, CD79A
21cytidine45 24 1111.7CD40LG, CD79A
22anti-fungal459.7CD79A, CD40LG
23ivig459.7CD40LG, CD79A
24doxycycline45 1110.7CD40LG, CD79A
25vitamin b12459.7CD40LG, CD79A
26neopterin459.7CD79A, CD40LG
27allergens459.7CD40LG, CD79A
28rituximab45 51 1111.7CD40LG, CD79A
29theophylline45 29 24 1112.7CD79A, CD40LG
30polyethylene glycol459.7CD40LG, CD79A
31biotin45 24 1111.6CD40LG, CD79A
32thyroxine45 2410.6CD40LG, CD79A
33hyaluronic acid45 2410.6CD40LG, CD79A
34formaldehyde45 2410.6CD79A, CD40LG
35folate459.6CD40LG, CD79A
36phosphatidylserine45 29 1111.6CD79A, CD40LG
37aspirin45 51 29 2412.5CD40LG, CD79A
38agar459.5CD40LG, CD79A
39epinephrine45 24 1111.5CD79A, CD40LG
40n acetylcysteine459.4CD40LG, CD79A
41ascorbic acid45 2410.4CD40LG, CD79A
42mannose459.4CD79A, ITGAX
43polysaccharide459.3CD79A, CD40LG
44acetylcholine45 51 29 24 1113.3CD40LG, CD79A
45norepinephrine45 24 1111.2CD40LG, CD79A
46histamine45 29 2411.0CD40LG, CD79A
47indomethacin45 29 61 1111.9ITGAX, CD79A, CD40LG
48fibrinogen458.9CD40LG, CD79A, ITGAX
49heparin45 29 24 1111.9CD40LG, CD79A, ITGAX
50retinoic acid45 249.8ITGAX, CD79A, CD40LG

GO Terms for genes affiliated with Sporotrichosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2CD40LG, CD79A, ITGAX
2plasma membraneGO:0058868.0CD40LG, CD79A, ITGAX, KCNB1

Biological processes related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.3CD40LG, CD79A
2B cell proliferationGO:0421009.0CD40LG, CD79A

Products for genes affiliated with Sporotrichosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sporotrichosis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet