MCID: SPR010
MIFTS: 47

Sporotrichosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Sporotrichosis

Aliases & Descriptions for Sporotrichosis:

Name: Sporotrichosis 12 50 56 3 3 42 14 69
Rose Gardener's Disease 50

Characteristics:

Orphanet epidemiological data:

56
sporotrichosis
Inheritance: Not applicable; Prevalence: >1/1000 (Mexico),1-5/10000 (Peru); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14484
ICD10 33 B42 B42.9
ICD9CM 35 117.1
MeSH 42 D013174
Orphanet 56 ORPHA826
MESH via Orphanet 43 D013174
UMLS via Orphanet 70 C0038034
ICD10 via Orphanet 34 B42.0 B42.1 B42.7 more
UMLS 69 C0038034

Summaries for Sporotrichosis

Disease Ontology : 12 A primary systemic mycosis that results_in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation.

MalaCards based summary : Sporotrichosis, also known as rose gardener's disease, is related to syphilis and alcoholic neuropathy. An important gene associated with Sporotrichosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and IL-2 Pathway. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

Wikipedia : 71 Sporotrichosis (also known as \"rose gardener\'s disease\") is a disease caused by the infection of the... more...

Related Diseases for Sporotrichosis

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
id Related Disease Score Top Affiliating Genes
1 syphilis 29.9 CD40LG CD79A
2 alcoholic neuropathy 10.3 CD40LG CD79A
3 camptodactyly vertebral fusion 10.3 CD40LG CD79A
4 spinal polio 10.3 CD40LG CD79A
5 rabies 10.3 CD40LG CD79A
6 unilateral retinoblastoma 10.3 CD40LG CD79A
7 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
8 delta chain disease 10.3 CD40LG CD79A
9 discitis 10.3 CD40LG CD79A
10 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
11 trichostrongyloidiasis 10.3 CD40LG CD79A
12 colloid adenoma 10.3 CD40LG CD79A
13 heart septal defect 10.3 CD40LG CD79A
14 cutaneous polyarteritis nodosa 10.3 CD40LG CD79A
15 mild pre-eclampsia 10.3 CD40LG CD79A
16 retinal microaneurysm 10.3 CD40LG CD79A
17 pediatric meningioma 10.3 CD40LG CD79A
18 tonsil cancer 10.3 CD40LG CD79A
19 indomethacin antenatal infection 10.3 CD40LG CD79A
20 postcricoid region cancer 10.3 CD40LG CD79A
21 beach ear 10.3 CD40LG CD79A
22 acute kidney tubular necrosis 10.3 CD40LG CD79A
23 atheroembolism of kidney 10.3 CD40LG CD79A
24 partial sensory epilepsy 10.3 CD40LG CD79A
25 ritscher-schinzel syndrome 1 10.3 CD40LG CD79A
26 diabetic angiopathy 10.3 CD40LG CD79A
27 endocarditis 10.3 CD40LG CD79A
28 muscular dystrophy 10.3 CD40LG CD79A
29 striatonigral degeneration 10.3 CD40LG CD79A
30 ciliary body spindle cell melanoma 10.3 CD40LG CD79A
31 purulent endophthalmitis 10.3 CD40LG CD79A
32 mu chain disease 10.3 CD40LG CD79A
33 generalized atherosclerosis 10.3 CD40LG CD79A
34 bursitis 10.3 CD40LG CD79A
35 homocystinuria 10.3 CD40LG CD79A
36 mental retardation, autosomal dominant 19 10.3 CD40LG CD79A
37 hemangioma of orbit 10.3 CD40LG CD79A
38 leiomyosarcoma 10.3 CD40LG CD79A
39 immunoglobulin beta deficiency 10.3 CD40LG CD79A
40 gestational diabetes 10.3 CD40LG CD79A
41 odontogenic myxoma 10.3 CD40LG CD79A
42 chronic mucocutaneous candidiasis 10.3 CD40LG CD79A
43 primary thrombocytopenia 10.2 CD40LG CD79A
44 alkhurma hemorrhagic fever 10.2 CD40LG CD79A
45 pedophilia 10.2 CD40LG CD79A
46 polyneuropathy due to drug 10.2 CD40LG CD79A
47 colonic benign neoplasm 10.2 CD40LG CD79A
48 cutaneous ganglioneuroma 10.2 CD40LG CD79A
49 ovarian serous cystadenocarcinoma 10.2 CD40LG CD79A
50 coronary artery dissection, spontaneous 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to Sporotrichosis

Symptoms & Phenotypes for Sporotrichosis

Drugs & Therapeutics for Sporotrichosis

Drugs for Sporotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 1, Phase 2 84625-61-6 55283
4 Antifungal Agents Phase 2,Phase 1
5 Anti-Infective Agents Phase 2,Phase 1
6 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
7 Cytochrome P-450 Enzyme Inhibitors Phase 2,Phase 1
8 Hormone Antagonists Phase 2,Phase 1
9 Hormones Phase 2,Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
11 Steroid Synthesis Inhibitors Phase 2,Phase 1
12 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
13 Hydroxyitraconazole Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis Completed NCT00004938 Phase 2
2 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2
3 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: sporotrichosis

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

MalaCards organs/tissues related to Sporotrichosis:

39
Skin, Bone, Lung, Brain, Testes, T Cells, Monocytes

Publications for Sporotrichosis

Articles related to Sporotrichosis:

(show top 50) (show all 581)
id Title Authors Year
1
Sporotrichosis of Maxillary Sinuses in a Middle Aged Female Patient from Rural Area of Eastern India. ( 27134873 )
2016
2
Periungual sporotrichosis: a diagnostic challenge. ( 27062149 )
2016
3
Chromoblastomycosis due to Fonsecaea monophora misdiagnosed as sporotrichosis and cutaneous tuberculosis in a pulmonary tuberculosis patient. ( 27330937 )
2016
4
Sporotrichosis: long-term treatment and follow-up in a diabetic patient from Southern Italy. ( 27595209 )
2016
5
Draft Genome Sequence of the Dimorphic Fungus Sporothrix pallida, a Nonpathogenic Species Belonging to Sporothrix, a Genus Containing Agents of Human and Feline Sporotrichosis. ( 27034494 )
2016
6
Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole. ( 27114300 )
2016
7
Disseminated cutaneous sporotrichosis associated with ocular lesion in an immunocompetent patient. ( 27579758 )
2016
8
Lower percentage of CD8+ T cells in peripheral blood of patients with sporotrichosis. ( 27181291 )
2016
9
Sporotrichosis-Associated Hospitalizations, United States, 2000-2013. ( 27648881 )
2016
10
In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil. ( 26591009 )
2016
11
A Case of Sporotrichosis Caused by Sporothrix globosa in Japan. ( 27081278 )
2016
12
Sporothrix chilensis sp. nov. (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals. ( 26781380 )
2016
13
Epidemiological investigation of an outbreak of cutaneous sporotrichosis, Northern Territory, Australia. ( 26758905 )
2016
14
Palpebral sporotrichosis in a 6-year-old child. ( 27496011 )
2016
15
Simultaneous onset of sporotrichosis in mother and daughter. ( 27774634 )
2016
16
Refractory sporotrichosis due to Sporothrix brasiliensis in humans appears to be unrelated to in vivo resistance. ( 27771622 )
2016
17
Sporotrichosis as an unusual case of osteomyelitis: A case report and review of the literature. ( 27158584 )
2016
18
Immune Response Induced by an Immunodominant 60a88kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. ( 27051673 )
2016
19
Is epidemic of sporotrichosis in Abancay, Peru, caused by zoonotic transmission of Sporothrix? ( 27746089 )
2016
20
Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study. ( 27207412 )
2016
21
Cutaneous Sporotrichosis Presenting as Clinical Feature of Facial Cellulitis in an Adult. ( 27489440 )
2016
22
Sporotrichosis in the Ocular Adnexa: 21 Cases in an Endemic Area in Peru and Review of the Literature. ( 26585212 )
2016
23
MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHOSIS IN PATIENTS WITH HIV/AIDS. ( 26967963 )
2016
24
A 27-Year-Old Severely Immunosuppressed Female with Misleading Clinical Features of Disseminated Cutaneous Sporotrichosis. ( 26881148 )
2016
25
Is There Any Difference between the In Situ and Systemic IL-10 and IFN-I^ Production when Clinical Forms of Cutaneous Sporotrichosis Are Compared? ( 27622513 )
2016
26
Atypical Cutaneous Sporotrichosis in an Immunocompetent Adult: Response to Potassium Iodide. ( 27057047 )
2016
27
Disseminated sporotrichosis in an immunocompetent patient. ( 27583270 )
2016
28
Clinical features of 10 cases of eyelid sporotrichosis in Jilin Province (Northeast China). ( 27521671 )
2016
29
Psoriasiform cutaneous sporotrichosis. ( 26206520 )
2015
30
Sporotrichosis in the Central Nervous System Caused by Sporothrix brasiliensis. ( 25956895 )
2015
31
Feline sporotrichosis: epidemiological and clinical aspects. ( 25477076 )
2015
32
The impact of sporotrichosis in HIV-infected patients: a systematic review. ( 25701221 )
2015
33
Sporotrichosis outbreak and mouldy a8"hay in NSW. ( 25901406 )
2015
34
Transmission electron microscopy analysis of skin lesions from sporotrichosis epidemic in Rio de Janeiro, Brazil. ( 25653392 )
2015
35
Lymphocutaneous Sporotrichosis during Treatment with Anti-TNF-Alpha Monotherapy. ( 25755904 )
2015
36
Leishmaniasis Panamensis Masquerading as Myiasis and Sporotrichosis: A Clinical Pitfall. ( 26413365 )
2015
37
Cryosurgery in association with itraconazole for the treatment of feline sporotrichosis. ( 25758667 )
2015
38
Sporotrichosis in an unusual location - Case report. ( 26312682 )
2015
39
Two cases of sporotrichosis of the right upper extremity in right-handed patients with diabetes mellitus. ( 25982353 )
2015
40
Scar examination in sporotrichosis: An additional tool for clinical diagnosis. ( 25784228 )
2015
41
Validation of a serodiagnostic test for sporotrichosis: a follow-up study of patients related to the Rio de Janeiro zoonotic outbreak. ( 25477075 )
2015
42
Sporothrix and sporotrichosis: contributions from the first international meeting sponsored by the Working Group on Sporothrix and sporotrichosis of the International Society for Human and Animal Mycology, Rio de Janeiro, Brazil, October, 2013. ( 25573890 )
2015
43
Hypersensitivity reaction to Sporothrix schenckii: erythema nodosum associated with sporotrichosis. ( 26312944 )
2015
44
Severe feline sporotrichosis associated with an increased population of CD8low cells and a decrease in CD4+ cells. ( 26483429 )
2015
45
Sporotrichosis: The Story of an Endemic Region in Peru over 28 Years (1985 to 2012). ( 26030742 )
2015
46
Global epidemiology of sporotrichosis. ( 25526781 )
2015
47
Pulmonary Sporotrichosis: An Evolving Clinical Paradigm. ( 26398541 )
2015
48
Deformity of the earlobe caused by fixed cutaneous sporotrichosis in a pediatric patient. ( 25778671 )
2015
49
Asexual propagation of a virulent clone complex in a human and feline outbreak of sporotrichosis. ( 25480940 )
2015
50
Molecular epidemiology of human sporotrichosis in Venezuela reveals high frequency of Sporothrix globosa. ( 25880588 )
2015

Variations for Sporotrichosis

Expression for Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for Sporotrichosis

Pathways related to Sporotrichosis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 CALM1 CALM2 CALM3 CD40LG CD79A
2
Show member pathways
13.05 CALM1 CALM2 CALM3 CD79A
3
Show member pathways
12.93 CALM1 CALM2 CALM3 CD79A
4
Show member pathways
12.77 CALM1 CALM2 CALM3 CD79A
5
Show member pathways
12.61 CALM1 CALM2 CALM3 CD79A
6
Show member pathways
12.58 CALM1 CALM2 CALM3 CD40LG
7
Show member pathways
12.51 CALM1 CALM2 CALM3 CD40LG
8
Show member pathways
12.47 CALM1 CALM2 CALM3 CD79A
9
Show member pathways
12.46 CALM1 CALM2 CALM3
10
Show member pathways
12.44 CALM1 CALM2 CALM3
11
Show member pathways
12.43 CALM1 CALM2 CALM3
12
Show member pathways
12.43 CALM1 CALM2 CALM3
13
Show member pathways
12.41 CALM1 CALM2 CALM3
14
Show member pathways
12.39 CALM1 CALM2 CALM3
15
Show member pathways
12.36 CALM1 CALM2 CALM3 CD40LG CD79A
16
Show member pathways
12.34 CALM1 CALM2 CALM3
17
Show member pathways
12.34 CALM1 CALM2 CALM3
18
Show member pathways
12.34 CALM1 CALM2 CD40LG
19
Show member pathways
12.32 CALM1 CALM2 CALM3
20
Show member pathways
12.32 CALM1 CALM2 CALM3
21
Show member pathways
12.32 CALM1 CALM2 CALM3
22
Show member pathways
12.3 CALM1 CALM2 CALM3
23 12.27 CALM1 CALM2 CALM3
24
Show member pathways
12.27 CALM1 CALM2 CALM3
25
Show member pathways
12.27 CALM1 CALM2 CALM3 CD40LG
26
Show member pathways
12.25 CALM1 CALM2 CALM3
27
Show member pathways
12.25 CALM1 CALM2 CALM3
28
Show member pathways
12.24 CALM1 CALM2 CALM3
29
Show member pathways
12.24 CALM1 CALM2 CALM3
30
Show member pathways
12.24 CALM1 CALM2 CALM3 CD79A
31
Show member pathways
12.23 CALM1 CALM2 CALM3
32
Show member pathways
12.2 CALM1 CALM2 CALM3
33
Show member pathways
12.17 CALM1 CALM2 CALM3
34
Show member pathways
12.17 CALM1 CALM2 CALM3
35
Show member pathways
12.16 CALM1 CALM2 CALM3
36
Show member pathways
12.15 CALM1 CALM2 CALM3
37 12.14 CALM1 CALM2 CALM3
38
Show member pathways
12.12 CALM1 CALM2 CALM3
39
Show member pathways
12.11 CALM1 CALM2 CALM3
40
Show member pathways
12.09 CALM1 CALM2 CALM3
41
Show member pathways
12.08 CALM1 CALM2 CALM3
42
Show member pathways
12.06 CALM1 CALM2 CALM3
43
Show member pathways
12.04 CALM1 CALM2 CALM3
44 12.01 CALM1 CALM2 CALM3
45 12.01 CALM1 CALM2 CALM3
46
Show member pathways
11.94 CALM1 CALM2 CALM3
47
Show member pathways
11.92 CALM1 CALM2 CALM3
48
Show member pathways
11.9 CALM1 CALM2 CALM3
49 11.85 CALM1 CALM2 CALM3
50 11.84 CALM1 CALM2 CALM3

GO Terms for Sporotrichosis

Cellular components related to Sporotrichosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.54 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.5 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.43 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.33 CALM1 CALM2 CALM3
5 spindle microtubule GO:0005876 9.13 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 8.8 CALM1 CALM2 CALM3

Biological processes related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.82 CALM1 CALM2 CALM3
2 Fc-epsilon receptor signaling pathway GO:0038095 9.81 CALM1 CALM2 CALM3
3 platelet degranulation GO:0002576 9.81 CALM1 CALM2 CALM3
4 muscle contraction GO:0006936 9.8 CALM1 CALM2 CALM3
5 response to calcium ion GO:0051592 9.8 CALM1 CALM2 CALM3
6 inositol phosphate metabolic process GO:0043647 9.79 CALM1 CALM2 CALM3
7 substantia nigra development GO:0021762 9.79 CALM1 CALM2 CALM3
8 protein methylation GO:0006479 9.78 CALM1 CALM2 CALM3
9 positive regulation of protein serine/threonine kinase activity GO:0071902 9.77 CALM1 CALM2 CALM3
10 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.77 CALM1 CALM2 CALM3
11 regulation of heart rate GO:0002027 9.76 CALM1 CALM2 CALM3
12 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.75 CALM1 CALM2 CALM3
13 regulation of rhodopsin mediated signaling pathway GO:0022400 9.74 CALM1 CALM2 CALM3
14 regulation of nitric-oxide synthase activity GO:0050999 9.73 CALM1 CALM2 CALM3
15 positive regulation of protein autophosphorylation GO:0031954 9.72 CALM1 CALM2 CALM3
16 regulation of cytokinesis GO:0032465 9.71 CALM1 CALM2 CALM3
17 regulation of cardiac muscle contraction GO:0055117 9.7 CALM1 CALM2 CALM3
18 positive regulation of protein dephosphorylation GO:0035307 9.69 CALM1 CALM2 CALM3
19 glycogen catabolic process GO:0005980 9.67 CALM1 CALM2 CALM3
20 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
21 B cell proliferation GO:0042100 9.64 CD40LG CD79A
22 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.63 CALM1 CALM2 CALM3
23 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
24 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
25 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
26 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
27 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
28 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
29 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
30 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.67 CALM1 CALM2 CALM3
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.65 CALM1 CALM2 CALM3
3 ion channel binding GO:0044325 9.63 CALM1 CALM2 CALM3
4 ligand-gated ion channel activity GO:0015276 9.61 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
6 phospholipase binding GO:0043274 9.54 CALM1 CALM2 CALM3
7 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
8 thioesterase binding GO:0031996 9.43 CALM1 CALM2 CALM3
9 inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440 9.33 CALM1 CALM2 CALM3
10 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
11 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Sporotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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