MCID: SPR010
MIFTS: 46

Sporotrichosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Sporotrichosis

MalaCards integrated aliases for Sporotrichosis:

Name: Sporotrichosis 12 50 56 3 3 42 14 69
Rose Gardener's Disease 50

Characteristics:

Orphanet epidemiological data:

56
sporotrichosis
Inheritance: Not applicable; Prevalence: >1/1000 (Mexico),1-5/10000 (Peru); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14484
ICD10 33 B42 B42.9
ICD9CM 35 117.1
MeSH 42 D013174
Orphanet 56 ORPHA826
MESH via Orphanet 43 D013174
UMLS via Orphanet 70 C0038034
ICD10 via Orphanet 34 B42.0 B42.1 B42.7 more
UMLS 69 C0038034

Summaries for Sporotrichosis

Disease Ontology : 12 A primary systemic mycosis that results_in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation.

MalaCards based summary : Sporotrichosis, also known as rose gardener's disease, is related to cryptococcosis and transmitted_by. An important gene associated with Sporotrichosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and lung.

Wikipedia : 72 Sporotrichosis (also known as \"rose gardener\'s disease\") is a disease caused by the infection of the... more...

Related Diseases for Sporotrichosis

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
id Related Disease Score Top Affiliating Genes
1 cryptococcosis 30.1 CD40LG IL10
2 transmitted_by 29.7 CD40LG CD79A
3 rheumatoid arthritis 28.8 CD40LG CD79A IFNG IL10
4 hairy cell leukemia 28.7 CALM1 CALM2 CALM3
5 balkan hemorrhagic fever 10.7 CD40LG IL10
6 facial paralysis 10.6 CD40LG IL10
7 eye accommodation disease 10.6 IFNG IL10
8 graft-versus-host disease, protection against 10.6 IFNG IL10
9 thelaziasis 10.6 IFNG IL10
10 reproductive system disease 10.6 CD40LG IL10
11 gerstmann syndrome 10.6 IFNG IL10
12 strawberry gallbladder 10.6 IFNG IL10
13 indian tick typhus 10.5 CD40LG IFNG
14 chlamydia 10.5 CD40LG IFNG
15 herpangina 10.5 IFNG IL10
16 tonsil cancer 10.5 IFNG IL10
17 chronic graft versus host disease 10.5 IFNG IL10
18 papillary squamous carcinoma 10.5 IFNG IL10
19 spindle cell hemangioma 10.5 IFNG IL10
20 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.5 IFNG IL10
21 cyclosporiasis 10.5 IFNG IL10
22 megaloblastic anemia 10.5 CD40LG IL10
23 alcoholic neuropathy 10.5 CD40LG CD79A
24 calloso-genital dysplasia 10.5 CD40LG CD79A
25 early-onset zonular cataract 10.5 IFNG IL10
26 variola major 10.5 CD40LG CD79A
27 mu chain disease 10.5 CD40LG CD79A
28 rabies 10.5 CD40LG CD79A
29 familial retinoblastoma 10.5 CD40LG CD79A
30 anti-basement membrane glomerulonephritis 10.5 CD40LG CD79A
31 microinvasive cervical squamous cell carcinoma 10.5 CD40LG CD79A
32 crustacean allergy 10.5 CD79A IL10
33 fetal erythroblastosis 10.5 CD40LG CD79A
34 spinal canal and spinal cord meningioma 10.5 CD40LG CD79A
35 trichostrongyloidiasis 10.5 CD40LG CD79A
36 leukodystrophy 10.5 CD40LG CD79A
37 retinal microaneurysm 10.5 CD40LG CD79A
38 senile reticular retinal degeneration 10.5 IFNG IL10
39 heart septal defect 10.5 CD40LG CD79A
40 cryptorchidism arachnodactyly mental retardation 10.5 CD40LG CD79A
41 acute kidney tubular necrosis 10.5 CD40LG CD79A
42 secretory meningioma 10.5 CD40LG CD79A
43 hodgkin's lymphoma, nodular sclerosis 10.5 CD40LG CD79A
44 imperforate oropharynx-costo vetebral anomalies 10.5 CD40LG CD79A
45 malignant otitis externa 10.5 CD40LG CD79A
46 transient hypogammaglobulinemia 10.5 CD40LG CD79A
47 benign epilepsy with centrotemporal spikes 10.5 CD40LG CD79A
48 distal monosomy 7q36 10.5 IFNG IL10
49 tongue cancer 10.5 CD40LG CD79A
50 hydrops of gallbladder 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to Sporotrichosis

Symptoms & Phenotypes for Sporotrichosis

Drugs & Therapeutics for Sporotrichosis

Drugs for Sporotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 1, Phase 2 84625-61-6 55283
4 Antifungal Agents Phase 2,Phase 1
5 Anti-Infective Agents Phase 2,Phase 1
6 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
7 Cytochrome P-450 Enzyme Inhibitors Phase 2,Phase 1
8 Hormone Antagonists Phase 2,Phase 1
9 Hormones Phase 2,Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
11 Steroid Synthesis Inhibitors Phase 2,Phase 1
12 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
13 Hydroxyitraconazole Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis Completed NCT00004938 Phase 2 fluconazole
2 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
3 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: sporotrichosis

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

MalaCards organs/tissues related to Sporotrichosis:

39
Bone, Skin, Lung, Brain, Testes, Liver, T Cells

Publications for Sporotrichosis

Articles related to Sporotrichosis:

(show top 50) (show all 592)
id Title Authors Year
1
Sporotrichosis in a liver transplant patient: A case report and literature review. ( 28702316 )
2017
2
Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar. ( 28847419 )
2017
3
Disseminated Sporotrichosis with Osteolytic Bone Involvement. ( 28349410 )
2017
4
Fungal infection control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosis. ( 28492800 )
2017
5
Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy. ( 28846164 )
2017
6
Cutaneous disseminated sporotrichosis: clinical experience of 24 cases. ( 28833587 )
2017
7
Sporotrichosis among children of a hyperendemic area in Peru: an 8-year retrospective study. ( 28488313 )
2017
8
Sporotrichosis masquerading as pyoderma gangrenosum. ( 28627095 )
2017
9
The Current Status of Feline Sporotrichosis in Malaysia. ( 28855477 )
2017
10
Efficacy of a poly-aggregated formulation of amphotericin B in treating systemic sporotrichosis caused by Sporothrix brasiliensis. ( 28575449 )
2017
11
Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission. ( 28103311 )
2017
12
Disseminated sporotrichosis in an immunocompetent patient. ( 27583270 )
2016
13
Draft Genome Sequence of the Dimorphic Fungus Sporothrix pallida, a Nonpathogenic Species Belonging to Sporothrix, a Genus Containing Agents of Human and Feline Sporotrichosis. ( 27034494 )
2016
14
Clinical features of 10 cases of eyelid sporotrichosis in Jilin Province (Northeast China). ( 27521671 )
2016
15
Cutaneous Sporotrichosis Presenting as Clinical Feature of Facial Cellulitis in an Adult. ( 27489440 )
2016
16
Disseminated cutaneous sporotrichosis associated with ocular lesion in an immunocompetent patient. ( 27579758 )
2016
17
Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study. ( 27207412 )
2016
18
Sporotrichosis of Maxillary Sinuses in a Middle Aged Female Patient from Rural Area of Eastern India. ( 27134873 )
2016
19
Chromoblastomycosis due to Fonsecaea monophora misdiagnosed as sporotrichosis and cutaneous tuberculosis in a pulmonary tuberculosis patient. ( 27330937 )
2016
20
A 27-Year-Old Severely Immunosuppressed Female with Misleading Clinical Features of Disseminated Cutaneous Sporotrichosis. ( 26881148 )
2016
21
Epidemiological investigation of an outbreak of cutaneous sporotrichosis, Northern Territory, Australia. ( 26758905 )
2016
22
Sporotrichosis in the Ocular Adnexa: 21 Cases in an Endemic Area in Peru and Review of the Literature. ( 26585212 )
2016
23
Refractory sporotrichosis due to Sporothrix brasiliensis in humans appears to be unrelated to in vivo resistance. ( 27771622 )
2016
24
Sporotrichosis: long-term treatment and follow-up in a diabetic patient from Southern Italy. ( 27595209 )
2016
25
Sporotrichosis-Associated Hospitalizations, United States, 2000-2013. ( 27648881 )
2016
26
Lower percentage of CD8+ T cells in peripheral blood of patients with sporotrichosis. ( 27181291 )
2016
27
Sporothrix chilensis sp. nov. (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals. ( 26781380 )
2016
28
Palpebral sporotrichosis in a 6-year-old child. ( 27496011 )
2016
29
Atypical Cutaneous Sporotrichosis in an Immunocompetent Adult: Response to Potassium Iodide. ( 27057047 )
2016
30
Periungual sporotrichosis: a diagnostic challenge. ( 27062149 )
2016
31
Immune Response Induced by an Immunodominant 60a88kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. ( 27051673 )
2016
32
A Case of Sporotrichosis Caused by Sporothrix globosa in Japan. ( 27081278 )
2016
33
In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil. ( 26591009 )
2016
34
Sporotrichosis as an unusual case of osteomyelitis: A case report and review of the literature. ( 27158584 )
2016
35
MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHOSIS IN PATIENTS WITH HIV/AIDS. ( 26967963 )
2016
36
Is There Any Difference between the In Situ and Systemic IL-10 and IFN-I^ Production when Clinical Forms of Cutaneous Sporotrichosis Are Compared? ( 27622513 )
2016
37
Is epidemic of sporotrichosis in Abancay, Peru, caused by zoonotic transmission of Sporothrix? ( 27746089 )
2016
38
Simultaneous onset of sporotrichosis in mother and daughter. ( 27774634 )
2016
39
Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole. ( 27114300 )
2016
40
What is your diagnosis? Fixed cutaneous sporotrichosis. ( 26682291 )
2015
41
Hypersensitivity reaction to Sporothrix schenckii: erythema nodosum associated with sporotrichosis. ( 26312944 )
2015
42
Eyelid sporotrichosis: Unique clinical findings in 72 patients. ( 25757013 )
2015
43
Pulmonary Sporotrichosis: An Evolving Clinical Paradigm. ( 26398541 )
2015
44
Cryosurgery in association with itraconazole for the treatment of feline sporotrichosis. ( 25758667 )
2015
45
Diagnostic accuracy assessment of cytopathological examination of feline sporotrichosis. ( 26092106 )
2015
46
Scar examination in sporotrichosis: An additional tool for clinical diagnosis. ( 25784228 )
2015
47
Leishmaniasis Panamensis Masquerading as Myiasis and Sporotrichosis: A Clinical Pitfall. ( 26413365 )
2015
48
Lymphocutaneous Sporotrichosis during Treatment with Anti-TNF-Alpha Monotherapy. ( 25755904 )
2015
49
Transmission electron microscopy analysis of skin lesions from sporotrichosis epidemic in Rio de Janeiro, Brazil. ( 25653392 )
2015
50
Severe feline sporotrichosis associated with an increased population of CD8low cells and a decrease in CD4+ cells. ( 26483429 )
2015

Variations for Sporotrichosis

Expression for Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for Sporotrichosis

Pathways related to Sporotrichosis according to GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CALM1 CALM2 CALM3 CD40LG CD79A IFNG
2
Show member pathways
13.62 CALM1 CALM2 CALM3 CD40LG IFNG IL10
3
Show member pathways
13.5 CALM1 CALM2 CALM3 CD40LG IFNG IL10
4
Show member pathways
13.4 CALM1 CALM2 CALM3 IFNG IL10
5
Show member pathways
13.32 CALM1 CALM2 CALM3 CD40LG CD79A
6
Show member pathways
13.2 CALM1 CALM2 CALM3 CD40LG IFNG IL10
7
Show member pathways
13.1 CALM1 CALM2 CALM3 CD79A IFNG
8
Show member pathways
12.95 CALM1 CALM2 CALM3 CD79A
9
Show member pathways
12.78 CALM1 CALM2 CALM3 CD79A
10
Show member pathways
12.64 CALM1 CALM2 CALM3 CD79A
11
Show member pathways
12.61 CALM1 CALM2 CALM3 CD40LG
12
Show member pathways
12.54 CALM1 CALM2 CALM3 CD40LG
13
Show member pathways
12.51 CALM1 CALM2 CALM3 CD79A
14
Show member pathways
12.45 CALM1 CALM2 CALM3
15 12.45 CD40LG CD79A IFNG IL10
16
Show member pathways
12.44 CALM1 CALM2 CALM3
17
Show member pathways
12.43 CALM1 CALM2 CALM3 IFNG
18
Show member pathways
12.36 CALM1 CALM2 CALM3
19
Show member pathways
12.35 CALM1 CALM2 CALM3
20
Show member pathways
12.34 CALM1 CALM2 CALM3
21
Show member pathways
12.33 CALM1 CALM2 CALM3
22
Show member pathways
12.33 CALM1 CALM2 CALM3
23
Show member pathways
12.32 CALM1 CALM2 CALM3
24
Show member pathways
12.31 CALM1 CALM2 CALM3 CD40LG
25
Show member pathways
12.3 CALM1 CALM2 CALM3 CD79A
26
Show member pathways
12.28 CALM1 CALM2 CALM3
27 12.28 CALM1 CALM2 CALM3
28
Show member pathways
12.27 CALM1 CALM2 CALM3
29
Show member pathways
12.27 CALM1 CALM2 CALM3
30
Show member pathways
12.26 CALM1 CALM2 CALM3
31
Show member pathways
12.25 CALM1 CALM2 CALM3
32
Show member pathways
12.25 CALM1 CALM2 CALM3
33
Show member pathways
12.22 CALM1 CALM2 CALM3
34
Show member pathways
12.19 CALM1 CALM2 CALM3
35
Show member pathways
12.19 CD40LG IFNG IL10
36
Show member pathways
12.18 CALM1 CALM2 CALM3
37
Show member pathways
12.18 CALM1 CALM2 CD40LG IFNG IL10
38
Show member pathways
12.17 CALM1 CALM2 CALM3
39
Show member pathways
12.17 CALM1 CALM2 CALM3 IFNG
40
Show member pathways
12.14 CALM1 CALM2 CALM3
41
Show member pathways
12.14 CALM1 CALM2 CALM3
42
Show member pathways
12.12 CALM1 CALM2 CALM3
43
Show member pathways
12.1 CALM1 CALM2 CALM3
44
Show member pathways
12.09 CALM1 CALM2 CALM3
45
Show member pathways
12.06 CALM1 CALM2 CALM3
46 12.04 CALM1 CALM2 CALM3
47
Show member pathways
11.97 CALM1 CALM2 CALM3
48 11.97 CALM1 CALM2 CALM3 IFNG
49
Show member pathways
11.95 CALM1 CALM2 CALM3
50 11.95 CD79A IFNG IL10

GO Terms for Sporotrichosis

Cellular components related to Sporotrichosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.5 CD40LG CD79A IFNG
2 spindle GO:0005819 9.43 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.33 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.13 CALM1 CALM2 CALM3
5 calcium channel complex GO:0034704 8.8 CALM1 CALM2 CALM3

Biological processes related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.76 CD40LG CD79A IL10
2 response to calcium ion GO:0051592 9.75 CALM1 CALM2 CALM3
3 B cell proliferation GO:0042100 9.74 CD40LG CD79A IL10
4 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
5 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
6 positive regulation of protein dephosphorylation GO:0035307 9.71 CALM1 CALM2 CALM3
7 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.7 CALM1 CALM2 CALM3
8 positive regulation of protein autophosphorylation GO:0031954 9.69 CALM1 CALM2 CALM3
9 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 CALM1 CALM2 CALM3
10 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
11 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.63 CALM1 CALM2 CALM3
12 positive regulation of interleukin-12 production GO:0032735 9.61 CD40LG IFNG
13 defense response to protozoan GO:0042832 9.61 IFNG IL10
14 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.61 CALM1 CALM2 CALM3
15 negative regulation of growth of symbiont in host GO:0044130 9.6 IFNG IL10
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 IFNG IL10
17 detection of calcium ion GO:0005513 9.58 CALM1 CALM2 CALM3
18 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.54 CALM1 CALM2 CALM3
19 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.5 CALM1 CALM2 CALM3
20 positive regulation of protein serine/threonine kinase activity GO:0071902 9.46 CALM1 CALM2 CALM3 IFNG
21 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.43 CALM1 CALM2 CALM3
22 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
23 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Sporotrichosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 CD40LG IFNG IL10
2 ion channel binding GO:0044325 9.43 CALM1 CALM2 CALM3
3 protein serine/threonine kinase activator activity GO:0043539 9.33 CALM1 CALM2 CALM3
4 titin binding GO:0031432 9.13 CALM1 CALM2 CALM3
5 protein phosphatase activator activity GO:0072542 8.8 CALM1 CALM2 CALM3

Sources for Sporotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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