MCID: SPR010
MIFTS: 52

Sporotrichosis malady

Rare diseases, Infectious diseases categories

Summaries for Sporotrichosis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A primary systemic mycosis that results in a systemic fungal infection, has material basis in sporothrix schenckii in animals and humans and results in formation of red papule at the site of inoculation.

MalaCards: Sporotrichosis, also known as sporotrichosis, unspecified, is related to syphilis and leukemia. An important gene associated with Sporotrichosis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are B Cell Receptor Signaling Pathway and Primary immunodeficiency. The drugs itraconazole and potassium iodide and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

CDC:4 The page you requested has been moved. Please update your links and bookmarks to the new Sporotrichosis web page.

Wikipedia:66 Sporotrichosis (also known as \"Rose gardener\'s disease\") is a disease caused by the infection of the... more...

Aliases & Classifications for Sporotrichosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
sporotrichosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of death: Normal


Aliases & Descriptions:

sporotrichosis 9 44 11 50 63
sporotrichosis, unspecified 9
rose gardener's disease 44
sporotrichosis nos 9


External Ids:

Disease Ontology9 DOID:14484
MeSH36 D013174
ICD9CM28 117.1
MESH via Orphanet37 D013174
ICD10 via Orphanet27 B42.0, B42.1, B42.7 B42.8, B42.9, more
SNOMED-CT via Orphanet60 42094007
UMLS via Orphanet64 C0038034
ICD1026 B42, B42.9

Related Diseases for Sporotrichosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis30.2CD79A
2leukemia30.0ITGAX, CD79A, CD40LG
3lupus erythematosus29.9CD40LG, CD79A
4arthritis10.3
5chromoblastomycosis10.2
6pyoderma gangrenosum10.2
7meningitis10.2
8pyoderma10.2
9acquired immunodeficiency syndrome10.2
10laryngitis10.2
11leishmaniasis10.2
12tuberculosis10.2
13mycetoma10.2
14rosacea10.1
15lepromatous leprosy10.1
16lymphangitis10.1
17secondary syphilis10.1
18blastomycosis10.1
19gout10.1
20hairy cell leukemia10.1
21histoplasmosis10.1
22keratoacanthoma10.1
23leprosy10.1
24osteomyelitis10.1
25sarcoidosis10.1
26sarcoma10.1
27q fever10.1CD79A
28macroglobulinemia10.1CD79A
29cryptosporidiosis10.1CD79A
30congenital toxoplasmosis10.0CD40LG, CD79A
31immunoglobulin g deficiency10.0CD40LG, CD79A
32selective iga deficiency disease10.0CD79A, CD40LG
33immunodeficiency, centromere instability and facial anomalies syndrome10.0CD40LG, CD79A
34immunoglobulin alpha deficiency10.0CD40LG, CD79A
35immunodeficiency with hyper igm type 110.0CD79A, CD40LG
36cryoglobulinemia10.0CD40LG, CD79A
37rubella10.0CD40LG, CD79A
38autoimmune hemolytic anemia10.0CD79A, CD40LG
39infectious mononucleosis10.0CD79A, CD40LG
40toxoplasmosis10.0CD40LG, CD79A
41agammaglobulinemia10.0CD79A, CD40LG
42immunodeficiency, common variable, 710.0CD79A, CD40LG
43common variable immune deficiency10.0CD40LG, CD79A
44ankylosing spondylitis10.0CD79A, CD40LG
45antiphospholipid syndrome10.0CD79A, CD40LG
46measles10.0CD40LG, CD79A
47schistosomiasis10.0CD40LG, CD79A
48polyneuropathy10.0CD79A, CD40LG
49lupus nephritis10.0CD40LG, CD79A
50iga glomerulonephritis10.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to sporotrichosis

Symptoms for Sporotrichosis

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Drugs & Therapeutics for Sporotrichosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Sporotrichosis

Drug clinical trials:

Search ClinicalTrials for Sporotrichosis

Search NIH Clinical Center for Sporotrichosis

Search CenterWatch for Sporotrichosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Sporotrichosis

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Anatomical Context for Sporotrichosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Sporotrichosis:

34
Skin, Bone, Lung, Brain, Liver, Breast, Testes, Monocytes

Animal Models for Sporotrichosis or affiliated genes

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Publications for Sporotrichosis

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Sources:
53PubMed
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Articles related to Sporotrichosis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study. (24328608)
2014
2
Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes. (23286352)
2013
3
A survey of 165 sporotrichosis cases examined in Nagasaki prefecture from 1951 to 2012. (24283850)
2013
4
Treatment abandonment in feline sporotrichosis - study of 147 cases. (22898261)
2013
5
Cutaneous disseminated sporotrichosis complicated by osteomyelitis. (22855250)
2013
6
Therapeutic monoclonal antibody for sporotrichosis. (23226146)
2012
7
Unusual clinical presentation of sporotrichosis in three members of one family. (22435433)
2012
8
Sporotrichosis in pregnancy: case reports of 5 patients in a zoonotic epidemic in Rio de Janeiro, Brazil. (22147042)
2011
9
Response to azolic antifungal agents for treating feline sporotrichosis. (20208075)
2010
10
Use of local hyperthermia to treat sporotrichosis in a cat. (20154314)
2010
11
Oral potassium iodide for the treatment of sporotrichosis. (19821356)
2009
12
Histopathology of canine sporotrichosis: a morphological study of 86 cases from Rio de Janeiro (2001-2007). (19360480)
2009
13
Asteroid body in sporotrichosis. Yeast viability and biological significance within the host immune response. (18608903)
2008
14
Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis. (18991286)
2008
15
Sporotrichosis in Mysore: a case report to emphasize the role of histopathology. (18417852)
2008
16
Immunoglobulins G, M, and A against Sporothrix schenckii exoantigens in patients with sporotrichosis before and during treatment with itraconazole. (17634504)
2007
17
Sporotrichosis: success of itraconazole treatment. (17215622)
2007
18
Extracutaneous sporotrichosis in a patient with liver cirrhosis. (17592891)
2007
19
Cytologic diagnosis of generalized cutaneous sporotrichosis in a hunting hound. (17311202)
2007
20
Emergence of sporotrichosis in Manipur. (16912444)
2006
21
Fatal sporotrichosis. (17121061)
2006
22
Localized cutaneous sporotrichosis in a child. (17043206)
2006
23
Humoral immune response against soluble and fractionate antigens in experimental sporotrichosis. (15681154)
2005
24
Laryngeal sporotrichosis mimicking merkel cell carcinoma recurrence. (15692552)
2005
25
Importance of the direct fresh examination in the diagnosis of cutaneous sporotrichosis. (15533061)
2004
26
Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998-2001). (15154732)
2004
27
Sporotrichosis with widespread cutaneous lesions: report of 24 cases related to transmission by domestic cats in Rio de Janeiro, Brazil. (12956676)
2003
28
Haematogenous spread of Sporothrix schenckii in cats with naturally acquired sporotrichosis. (14510328)
2003
29
Phenotyping and genotyping of Sporothrix schenckii isolates according to geographic origin and clinical form of Sporotrichosis. (12149366)
2002
30
A case of cutaneous disseminated sporotrichosis. (11320714)
2001
31
A case of lymphocutaneous sporotrichosis]. (11479537)
2001
32
MR imaging appearance of cutaneous sporotrichosis. (10350324)
1999
33
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
34
The asteroid bodies of sporotrichosis. (9650696)
1998
35
Neck skin sporotrichosis after electrolysis. (9462788)
1998
36
Sporotrichosis: a case report and successful treatment with itraconazole. (9283771)
1997
37
Sporotrichosis: nasal obstruction in an infant. (8801823)
1996
38
Successful treatment of cutaneous sporotrichosis with liquid nitrogen: report of three cases. (8559191)
1995
39
Fatal pulmonary sporotrichosis caused by Sporothrix schenckii var. luriei in India. (1401023)
1992
40
Sporotrichosis in human immunodeficiency virus-infected patients: report of a case. (1962081)
1991
41
Feline sporotrichosis: an increasingly important zoonotic disease in Malaysia. (2270639)
1990
42
A familial occurrence of sporotrichosis. (2365904)
1990
43
Sporotrichosis in the Orinoco river basin of Venezuela and Colombia. (2739691)
1989
44
Multistate outbreak of sporotrichosis in seedling handlers, 1988. (2971870)
1988
45
Abnormal bone and gallium scans in a case of multifocal systemic sporotrichosis. (3769363)
1986
46
Sporotrichosis in India: first authentic case report from the north-western region and a critical literature review. (3746583)
1986
47
Articular sporotrichosis. (3956012)
1986
48
Fixed cutaneous sporotrichosis: unusual histopathology following intralesional corticosteroid administration. (4008700)
1985
49
Sporotrichosis research in the Transvaal--how it began 60 years ago. (3892731)
1985
50
Tropical fish aquariums. A source of Mycobacterium marinum infections resembling sporotrichosis. (5466918)
1970

Variations for Sporotrichosis

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Expression for genes affiliated with Sporotrichosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for genes affiliated with Sporotrichosis

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Sporotrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.3CD40LG, CD79A
29.3CD40LG, CD79A

Compounds for genes affiliated with Sporotrichosis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Sporotrichosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1sulfolipid i469.8CD40LG, CD79A
2sandoglobulin469.8CD40LG, CD79A
3gamma globulin469.8CD40LG, CD79A
4vancomycin46 1210.8CD79A, CD40LG
5pneumococcal469.8CD40LG, CD79A
6blys469.8CD40LG, CD79A
7tuberculin469.8CD40LG, CD79A
8praziquantel46 1210.8CD40LG, CD79A
9hemocyanin469.8CD79A, CD40LG
10gliadin469.8CD40LG, CD79A
11pmma469.8CD79A, CD40LG
12silicone469.8CD40LG, CD79A
13mannan469.7CD40LG, CD79A
14okt3469.7CD79A, CD40LG
15glutaraldehyde469.7CD40LG, CD79A
16sulfasalazine30 46 52 1212.7CD40LG, CD79A
17cardiolipin46 1210.7CD79A, CD40LG
18valproate469.7CD40LG, CD79A
19mycophenolate mofetil46 52 1211.7CD79A, CD40LG
20phenytoin46 52 30 1212.7CD40LG, CD79A
21cytidine46 25 1211.7CD40LG, CD79A
22anti-fungal469.7CD79A, CD40LG
23ivig469.7CD40LG, CD79A
24doxycycline46 1210.7CD40LG, CD79A
25vitamin b12469.7CD40LG, CD79A
26neopterin469.7CD79A, CD40LG
27allergens469.7CD40LG, CD79A
28rituximab46 52 1211.7CD40LG, CD79A
29theophylline46 30 25 1212.7CD79A, CD40LG
30polyethylene glycol469.7CD40LG, CD79A
31biotin46 25 1211.6CD40LG, CD79A
32thyroxine46 2510.6CD40LG, CD79A
33hyaluronic acid46 2510.6CD40LG, CD79A
34formaldehyde46 2510.6CD79A, CD40LG
35folate469.6CD40LG, CD79A
36phosphatidylserine46 30 1211.6CD79A, CD40LG
37aspirin46 52 30 2512.5CD40LG, CD79A
38agar469.5CD40LG, CD79A
39epinephrine46 25 1211.5CD79A, CD40LG
40n acetylcysteine469.4CD40LG, CD79A
41ascorbic acid46 2510.4CD40LG, CD79A
42mannose469.4CD79A, ITGAX
43polysaccharide469.3CD79A, CD40LG
44acetylcholine46 52 30 25 1213.3CD40LG, CD79A
45norepinephrine46 25 1211.2CD40LG, CD79A
46histamine46 30 2511.0CD40LG, CD79A
47indomethacin46 30 62 1211.9ITGAX, CD79A, CD40LG
48fibrinogen468.9CD40LG, CD79A, ITGAX
49heparin46 30 25 1211.9CD40LG, CD79A, ITGAX
50retinoic acid46 259.8ITGAX, CD79A, CD40LG

GO Terms for genes affiliated with Sporotrichosis

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Sources:
17Gene Ontology
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Cellular components related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2CD40LG, CD79A, ITGAX
2plasma membraneGO:0058868.0CD40LG, CD79A, ITGAX, KCNB1

Biological processes related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.3CD40LG, CD79A
2B cell proliferationGO:0421009.0CD40LG, CD79A

Products for genes affiliated with Sporotrichosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sporotrichosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet