MCID: SPR010
MIFTS: 46

Sporotrichosis malady

Infectious category

Summaries for Sporotrichosis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Sporotrichosis is an infection caused by a fungus called Sporothrix schenckii. The fungus lives throughout the world in soil, plants, and decaying vegetation. Cutaneous (skin) infection is the most common form of infection and usually occurs after handling contaminated plant material, when the fungus enters the skin through a small cut or scrape.

MalaCards: Sporotrichosis, also known as sporotrichosis, unspecified, is related to syphilis and arthritis. An important gene associated with Sporotrichosis is BAG3 (BCL2-associated athanogene 3), and among its related pathways is Primary immunodeficiency. The drugs potassium iodide and itraconazole and the compounds fluconazole and sulfolipid i have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain.

Disease Ontology:8 A primary systemic mycosis that results in a systemic fungal infection, has material basis in sporothrix schenckii in animals and humans and results in formation of red papule at the site of inoculation.

Wikipedia:64 Sporotrichosis (also known as \"Rose gardener\'s disease\") is a disease caused by the infection of the... more...

Aliases & Classifications for Sporotrichosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
sporotrichosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of death: Normal


Aliases & Descriptions:

sporotrichosis 8 43 10 49 61
sporotrichosis, unspecified 8
rose gardener's disease 43
sporotrichosis nos 8


External Ids:

Disease Ontology8 DOID:14484
MeSH35 D013174
ICD9CM27 117.1
MESH via Orphanet36 D013174
ICD10 via Orphanet26 B42
SNOMED-CT via Orphanet58 42094007
UMLS via Orphanet62 C0038034
ICD1025 B42, B42.9

Related Diseases for Sporotrichosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis30.1CD79A
2arthritis10.3
3chromoblastomycosis10.2
4pyoderma gangrenosum10.2
5acquired immunodeficiency syndrome10.2
6tuberculosis10.2
7mycetoma10.2
8gout10.1
9rosacea10.1
10lymphangitis10.1
11lepromatous leprosy10.1
12secondary syphilis10.1
13blastomycosis10.1
14polyclonal hypergammaglobulinemia10.0CD79A
15diphtheria10.0CD79A
16giardiasis10.0CD79A
17cryptosporidiosis10.0CD79A
18gastritis10.0CD79A
19meningoencephalitis10.0CD79A
20dermatitis herpetiformis10.0CD79A
21pemphigus foliaceus10.0CD79A
22q fever10.0CD79A
23brucellosis10.0CD79A
24hairy cell leukemia10.0ITGAX
25mumps10.0CD79A
26pyelonephritis10.0CD79A
27acute leukemia10.0ITGAX
28macroglobulinemia10.0CD79A
29cd40 ligand deficiency10.0CD40LG
30guillain-barre syndrome10.0CD40LG
31leptospirosis10.0CD40LG
32herpes simplex10.0CD79A
33candidiasis10.0HTN3, CD79A
34congenital toxoplasmosis10.0CD79A, CD40LG
35immunoglobulin g deficiency10.0CD79A, CD40LG
36selective iga deficiency disease10.0CD40LG, CD79A
37immunodeficiency, centromere instability and facial anomalies syndrome10.0CD79A, CD40LG
38immunoglobulin alpha deficiency10.0CD40LG, CD79A
39immunodeficiency with hyper igm type 110.0CD79A, CD40LG
40infectious mononucleosis10.0CD40LG, CD79A
41immunodeficiency, common variable, 710.0CD40LG, CD79A
42periodontal disease10.0HTN3, CD79A
43ankylosing spondylitis10.0CD79A, CD40LG
44autoimmune hemolytic anemia10.0CD79A, CD40LG
45cryoglobulinemia10.0CD40LG, CD79A
46agammaglobulinemia10.0CD79A, CD40LG
47iga glomerulonephritis10.0CD79A, CD40LG
48primary biliary cirrhosis10.0CD79A, CD40LG
49rubella10.0CD79A, CD40LG
50vasculitis10.0CD79A, CD40LG, ITGAX

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to sporotrichosis

Clinical Features for Sporotrichosis

Drugs & Therapeutics for Sporotrichosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sporotrichosis

Drug clinical trials:

Search ClinicalTrials for Sporotrichosis

Search NIH Clinical Center for Sporotrichosis

Search CenterWatch for Sporotrichosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Sporotrichosis:

33
Skin, Liver, Brain, Lung, Breast, Monocytes, B cells

Animal Models for Sporotrichosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sporotrichosis

Sources:
51PubMed
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Articles related to Sporotrichosis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
A survey of 165 sporotrichosis cases examined in Nagasaki prefecture from 1951 to 2012. (24283850)
2013
2
Report of 457 sporotrichosis cases from Jilin province, northeast China, a serious endemic region. (22176524)
2013
3
Pregnancy during a sporotrichosis epidemic in Rio de Janeiro, Brazil. (22445393)
2012
4
Sporotrichosis in pregnancy: case reports of 5 patients in a zoonotic epidemic in Rio de Janeiro, Brazil. (22147042)
2011
5
Sporothrix schenckii and Sporotrichosis. (21976602)
2011
6
Cutaneous sporotrichosis treatment with potassium iodide: a 24 year experience in SALo Paulo State, Brazil. (21537756)
2011
7
Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. (21103938)
2011
8
Disseminated sporotrichosis. (22700076)
2011
9
Phenotypic and molecular identification of Sporothrix isolates from an epidemic area of sporotrichosis in Brazil. (21701792)
2011
10
Cross-reactivity in the Histoplasma antigen enzyme immunoassay caused by sporotrichosis. (21813658)
2011
11
Cutaneous sporotrichosis: unusual clinical presentations. (20445301)
2010
12
Subcutaneous mycoses: chromoblastomycosis, sporotrichosis and mycetoma. (20529168)
2010
13
Oral potassium iodide for the treatment of sporotrichosis. (19130293)
2009
14
Prominent facial edema caused by potassium iodide solution in a patient with sporotrichosis. (19284458)
2009
15
Sporotrichosis: a retrospective evaluation of 23 cases seen in northern California (1987-2007). (19659536)
2009
16
Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis. (18991286)
2008
17
Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. (24031298)
2008
18
Fine-needle aspiration biopsy of disseminated sporotrichosis: a case report. (18231999)
2008
19
Immunoglobulins G, M, and A against Sporothrix schenckii exoantigens in patients with sporotrichosis before and during treatment with itraconazole. (17634504)
2007
20
Sporotrichosis in childhood: clinical and therapeutic experience in 25 patients. (17845157)
2007
21
Sporotrichosis in north-east India. (17472617)
2007
22
Disseminated sporotrichosis presenting with granulomatous inflammatory multiple mononeuropathies. (17623855)
2007
23
Cat-transmitted sporotrichosis, Rio de Janeiro, Brazil. (16485488)
2005
24
Cutaneous tuberculosis mimicking sporotrichosis. (15684464)
2005
25
Multifocal sporotrichosis with meningeal involvement in a patient with AIDS. (15832562)
2005
26
Cutaneous sporotrichosis in Himachal Pradesh, India. (15679662)
2005
27
Lymphocutaneous sporotrichosis treated with three different modalities. (17642877)
2003
28
Disseminated cutaneous sporotrichosis treated with itraconazole. (12041817)
2002
29
Sporotrichosis in patient with AIDS: report of a case and review. (15487924)
2001
30
Sporotrichosis masquerading as pyoderma gangrenosum: case report and review of 19 cases of sporotrichosis. (11843223)
2001
31
Bursal sporotrichosis: case report and review. (10987734)
2000
32
Sporotrichosis in a Queensland bushwalker. (9762077)
1998
33
Long-term follow-up of multifocal osteoarticular sporotrichosis treated with itraconazole. (8842282)
1996
34
Response of sporotrichosis granuloma to local application of iodine. (8962526)
1996
35
Three-phase bone and Ga-67 scintigraphy in disseminated sporotrichosis. (8616999)
1995
36
Bonsai tree: risk factor for disseminated sporotrichosis. (7593792)
1995
37
A case of sporotrichosis treated successfully with oral fluconazole 200 mg once weekly. (7739660)
1994
38
Pulmonary sporotrichosis treated with itraconazole. (8380267)
1993
39
Sporotrichosis in human immunodeficiency virus-infected patients: report of a case. (1962081)
1991
40
Cutaneous sporotrichosis in Thailand: first reported case. (2103588)
1990
41
Leads from the MMWR. Multistate outbreak of sporotrichosis in seedling handlers, 1988. (2972847)
1988
42
Local hyperthermia in the treatment of sporotrichosis. (3657854)
1987
43
Three cases of sporotrichosis with numerous fungal elements. (3320132)
1987
44
Extracutaneous sporotrichosis. (3584893)
1987
45
Fixed cutaneous sporotrichosis: unusual histopathology following intralesional corticosteroid administration. (4008700)
1985
46
Spontaneous disappearance of cutaneous sporotrichosis. Report of two cases. (4066092)
1985
47
Cutaneous lymphatic sporotrichosis treated with ketoconazole--report of an infection acquired in the United Kingdom. (6094056)
1984
48
Pleural sporotrichosis. (6617294)
1983
49
Sporotrichosis in pregnancy. (7172752)
1982
50
Sporotrichosis--first case report from Madras. (7177162)
1982

Genetic Variations for Sporotrichosis

Expression for genes affiliated with Sporotrichosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for genes affiliated with Sporotrichosis

Sources:
30KEGG
See all sources

Pathways related to Sporotrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CD79A, CD40LG

Compounds for genes affiliated with Sporotrichosis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Sporotrichosis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1fluconazole45 1110.7CD79A, HTN3
2sulfolipid i459.7CD79A, CD40LG
3sandoglobulin459.7CD40LG, CD79A
4vancomycin45 1110.7CD79A, CD40LG
5pneumococcal459.7CD79A, CD40LG
6blys459.7CD79A, CD40LG
7tuberculin459.7CD40LG, CD79A
8praziquantel45 1110.7CD79A, CD40LG
9hemocyanin459.7CD79A, CD40LG
10gliadin459.7CD79A, CD40LG
11silicone459.7CD40LG, CD79A
12mannan459.7CD79A, CD40LG
13okt3459.6CD40LG, CD79A
14glutaraldehyde459.6CD79A, CD40LG
15sulfasalazine45 29 50 1112.6CD79A, CD40LG
16cardiolipin45 1110.6CD40LG, CD79A
17mycophenolate mofetil45 50 1111.6CD79A, CD40LG
18valproate459.6CD40LG, CD79A
19phenytoin45 50 29 1112.6CD79A, CD40LG
20cytidine45 11 2411.6CD79A, CD40LG
21ivig459.5CD79A, CD40LG
22doxycycline45 1110.5CD40LG, CD79A
23vitamin b12459.5CD79A, CD40LG
24neopterin459.4CD79A, CD40LG
25rituximab45 50 1111.3CD40LG, CD79A
26polyethylene glycol459.3CD79A, CD40LG
27pmma459.3CD79A, CD40LG, HTN3
28anti-fungal459.3CD79A, CD40LG, HTN3
29allergens459.2CD79A, CD40LG
30theophylline45 29 11 2412.0CD79A, CD40LG
31fibrinogen458.8CD79A, CD40LG, ITGAX
32heparin45 29 11 2411.6CD79A, CD40LG, ITGAX

GO Terms for genes affiliated with Sporotrichosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2CD79A, CD40LG, ITGAX
2plasma membraneGO:0058867.6CD79A, CD40LG, BAG3, ITGAX, KCNB1

Biological processes related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.3CD79A, CD40LG
2B cell proliferationGO:0421009.0CD79A, CD40LG

Products for genes affiliated with Sporotrichosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sporotrichosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet