MCID: SPR010
MIFTS: 53

Sporotrichosis malady

Rare diseases, Infectious diseases categories
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Summaries for Sporotrichosis

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Disease Ontology:8 A primary systemic mycosis that results in a systemic fungal infection, has material basis in sporothrix schenckii in animals and humans and results in formation of red papule at the site of inoculation.

MalaCards based summary: Sporotrichosis, also known as sporotrichosis, unspecified, is related to syphilis and lupus erythematosus. An important gene associated with Sporotrichosis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are B Cell Receptor Signaling Pathway and Primary immunodeficiency. The drugs potassium iodide and itraconazole and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and lung.

CDC:3 Meet Terrie

Wikipedia:65 Sporotrichosis (also known as \"Rose gardener\'s disease\") is a disease caused by the infection of the... more...

Aliases & Classifications for Sporotrichosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Sporotrichosis, Aliases & Descriptions:

Name: Sporotrichosis 8 42 10 48 62
Sporotrichosis, Unspecified 8
 
Rose Gardener's Disease 42
Sporotrichosis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
sporotrichosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of death: Normal


External Ids:

Disease Ontology8 DOID:14484
ICD9CM27 117.1
MeSH34 D013174
MESH via Orphanet35 D013174
ICD10 via Orphanet26 B42.0, B42.1, B42.7 B42.8, B42.9, more
UMLS via Orphanet63 C0038034
ICD1025 B42, B42.9

Related Diseases for Sporotrichosis

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Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis30.6CD79A
2lupus erythematosus29.9CD40LG, CD79A
3leukemia29.4ITGAX, CD79A, CD40LG
4arthritis10.3
5q fever10.3CD79A
6macroglobulinemia10.3CD79A
7cryptosporidiosis10.3CD79A
8chromoblastomycosis10.2
9pyoderma gangrenosum10.2
10pyoderma10.2
11acquired immunodeficiency syndrome10.2
12laryngitis10.2
13leishmaniasis10.2
14meningitis10.2
15tuberculosis10.2
16mycetoma10.2
17gout10.1
18lymphangitis10.1
19blastomycosis10.1
20rosacea10.1
21lepromatous leprosy10.1
22secondary syphilis10.1
23histoplasmosis10.1
24keratoacanthoma10.1
25leprosy10.1
26osteomyelitis10.1
27sarcoidosis10.1
28sarcoma10.1
29congenital toxoplasmosis10.1CD40LG, CD79A
30immunoglobulin g deficiency10.1CD40LG, CD79A
31selective iga deficiency disease10.1CD79A, CD40LG
32immunodeficiency, centromere instability and facial anomalies syndrome10.1CD40LG, CD79A
33immunoglobulin alpha deficiency10.1CD40LG, CD79A
34immunodeficiency with hyper igm type 110.1CD79A, CD40LG
35bruton-type agammaglobulinemia10.1CD40LG, CD79A
36cryoglobulinemia10.1CD40LG, CD79A
37rubella10.1CD40LG, CD79A
38autoimmune hemolytic anemia10.0CD79A, CD40LG
39infectious mononucleosis10.0CD79A, CD40LG
40toxoplasmosis10.0CD40LG, CD79A
41agammaglobulinemia10.0CD79A, CD40LG
42common variable immunodeficiency10.0CD40LG, CD79A
43ankylosing spondylitis10.0CD79A, CD40LG
44antiphospholipid syndrome10.0CD79A, CD40LG
45measles10.0CD40LG, CD79A
46schistosomiasis10.0CD40LG, CD79A
47polyneuropathy10.0CD79A, CD40LG
48lupus nephritis10.0CD40LG, CD79A
49berger disease10.0CD79A, CD40LG
50connective tissue disease10.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to sporotrichosis

Symptoms for Sporotrichosis

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Drugs & Therapeutics for Sporotrichosis

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Drug clinical trials:

Search ClinicalTrials for Sporotrichosis

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Sporotrichosis

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Anatomical Context for Sporotrichosis

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MalaCards organs/tissues related to Sporotrichosis:

32
Bone, Skin, Lung, Brain, Testes, Liver, Breast, Monocytes

Animal Models for Sporotrichosis or affiliated genes

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Publications for Sporotrichosis

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Articles related to Sporotrichosis:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients. (25229626)
2014
2
Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study. (24328608)
2014
3
Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes. (23286352)
2013
4
A survey of 165 sporotrichosis cases examined in Nagasaki prefecture from 1951 to 2012. (24283850)
2013
5
Treatment abandonment in feline sporotrichosis - study of 147 cases. (22898261)
2013
6
Cutaneous disseminated sporotrichosis complicated by osteomyelitis. (22855250)
2013
7
Therapeutic monoclonal antibody for sporotrichosis. (23226146)
2012
8
Unusual clinical presentation of sporotrichosis in three members of one family. (22435433)
2012
9
Sporotrichosis in pregnancy: case reports of 5 patients in a zoonotic epidemic in Rio de Janeiro, Brazil. (22147042)
2011
10
Response to azolic antifungal agents for treating feline sporotrichosis. (20208075)
2010
11
Use of local hyperthermia to treat sporotrichosis in a cat. (20154314)
2010
12
Oral potassium iodide for the treatment of sporotrichosis. (19821356)
2009
13
Histopathology of canine sporotrichosis: a morphological study of 86 cases from Rio de Janeiro (2001-2007). (19360480)
2009
14
Asteroid body in sporotrichosis. Yeast viability and biological significance within the host immune response. (18608903)
2008
15
Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis. (18991286)
2008
16
Sporotrichosis in Mysore: a case report to emphasize the role of histopathology. (18417852)
2008
17
Immunoglobulins G, M, and A against Sporothrix schenckii exoantigens in patients with sporotrichosis before and during treatment with itraconazole. (17634504)
2007
18
Sporotrichosis: success of itraconazole treatment. (17215622)
2007
19
Extracutaneous sporotrichosis in a patient with liver cirrhosis. (17592891)
2007
20
Cytologic diagnosis of generalized cutaneous sporotrichosis in a hunting hound. (17311202)
2007
21
Emergence of sporotrichosis in Manipur. (16912444)
2006
22
Fatal sporotrichosis. (17121061)
2006
23
Localized cutaneous sporotrichosis in a child. (17043206)
2006
24
Humoral immune response against soluble and fractionate antigens in experimental sporotrichosis. (15681154)
2005
25
Laryngeal sporotrichosis mimicking merkel cell carcinoma recurrence. (15692552)
2005
26
Importance of the direct fresh examination in the diagnosis of cutaneous sporotrichosis. (15533061)
2004
27
Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998-2001). (15154732)
2004
28
Sporotrichosis with widespread cutaneous lesions: report of 24 cases related to transmission by domestic cats in Rio de Janeiro, Brazil. (12956676)
2003
29
Haematogenous spread of Sporothrix schenckii in cats with naturally acquired sporotrichosis. (14510328)
2003
30
Phenotyping and genotyping of Sporothrix schenckii isolates according to geographic origin and clinical form of Sporotrichosis. (12149366)
2002
31
A case of cutaneous disseminated sporotrichosis. (11320714)
2001
32
A case of lymphocutaneous sporotrichosis]. (11479537)
2001
33
MR imaging appearance of cutaneous sporotrichosis. (10350324)
1999
34
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
35
The asteroid bodies of sporotrichosis. (9650696)
1998
36
Neck skin sporotrichosis after electrolysis. (9462788)
1998
37
Sporotrichosis: a case report and successful treatment with itraconazole. (9283771)
1997
38
Sporotrichosis: nasal obstruction in an infant. (8801823)
1996
39
Fatal pulmonary sporotrichosis caused by Sporothrix schenckii var. luriei in India. (1401023)
1992
40
Sporotrichosis in human immunodeficiency virus-infected patients: report of a case. (1962081)
1991
41
Feline sporotrichosis: an increasingly important zoonotic disease in Malaysia. (2270639)
1990
42
A familial occurrence of sporotrichosis. (2365904)
1990
43
Sporotrichosis in the Orinoco river basin of Venezuela and Colombia. (2739691)
1989
44
Multistate outbreak of sporotrichosis in seedling handlers, 1988. (2971870)
1988
45
Abnormal bone and gallium scans in a case of multifocal systemic sporotrichosis. (3769363)
1986
46
Sporotrichosis in India: first authentic case report from the north-western region and a critical literature review. (3746583)
1986
47
Articular sporotrichosis. (3956012)
1986
48
Fixed cutaneous sporotrichosis: unusual histopathology following intralesional corticosteroid administration. (4008700)
1985
49
Sporotrichosis research in the Transvaal--how it began 60 years ago. (3892731)
1985
50
Tropical fish aquariums. A source of Mycobacterium marinum infections resembling sporotrichosis. (5466918)
1970

Variations for Sporotrichosis

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Expression for genes affiliated with Sporotrichosis

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Expression patterns in normal tissues for genes affiliated with Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for genes affiliated with Sporotrichosis

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Pathways related to Sporotrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.3CD40LG, CD79A
29.3CD40LG, CD79A

Compounds for genes affiliated with Sporotrichosis

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Compounds related to Sporotrichosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1sulfolipid i449.8CD40LG, CD79A
2sandoglobulin449.8CD40LG, CD79A
3gamma globulin449.8CD40LG, CD79A
4vancomycin44 1110.8CD79A, CD40LG
5pneumococcal449.8CD40LG, CD79A
6blys449.8CD40LG, CD79A
7tuberculin449.8CD40LG, CD79A
8praziquantel44 1110.8CD40LG, CD79A
9hemocyanin449.8CD79A, CD40LG
10gliadin449.8CD40LG, CD79A
11pmma449.8CD79A, CD40LG
12silicone449.8CD40LG, CD79A
13mannan449.7CD40LG, CD79A
14okt3449.7CD79A, CD40LG
15glutaraldehyde449.7CD40LG, CD79A
16sulfasalazine28 44 50 1112.7CD40LG, CD79A
17cardiolipin44 1110.7CD79A, CD40LG
18valproate449.7CD40LG, CD79A
19mycophenolate mofetil44 50 1111.7CD79A, CD40LG
20phenytoin44 50 28 1112.7CD40LG, CD79A
21cytidine44 24 1111.7CD40LG, CD79A
22anti-fungal449.7CD79A, CD40LG
23ivig449.7CD40LG, CD79A
24doxycycline44 1110.7CD40LG, CD79A
25vitamin b12449.7CD40LG, CD79A
26neopterin449.7CD79A, CD40LG
27allergens449.7CD40LG, CD79A
28rituximab44 50 1111.7CD40LG, CD79A
29theophylline44 28 24 1112.7CD79A, CD40LG
30polyethylene glycol449.7CD40LG, CD79A
31biotin44 24 1111.6CD40LG, CD79A
32thyroxine44 2410.6CD40LG, CD79A
33hyaluronic acid44 2410.6CD40LG, CD79A
34formaldehyde44 2410.6CD79A, CD40LG
35folate449.6CD40LG, CD79A
36phosphatidylserine44 28 1111.6CD79A, CD40LG
37aspirin44 50 28 2412.5CD40LG, CD79A
38agar449.5CD40LG, CD79A
39epinephrine44 24 1111.5CD79A, CD40LG
40n acetylcysteine449.4CD40LG, CD79A
41ascorbic acid44 2410.4CD40LG, CD79A
42mannose449.4CD79A, ITGAX
43polysaccharide449.3CD79A, CD40LG
44acetylcholine44 50 28 24 1113.3CD40LG, CD79A
45norepinephrine44 24 1111.2CD40LG, CD79A
46histamine44 28 2411.0CD40LG, CD79A
47indomethacin44 28 61 1111.9ITGAX, CD79A, CD40LG
48fibrinogen448.9CD40LG, CD79A, ITGAX
49heparin44 28 24 1111.9CD40LG, CD79A, ITGAX
50retinoic acid44 249.8ITGAX, CD79A, CD40LG

GO Terms for genes affiliated with Sporotrichosis

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Cellular components related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2CD40LG, CD79A, ITGAX
2plasma membraneGO:0058868.0CD40LG, CD79A, ITGAX, KCNB1

Biological processes related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.3CD40LG, CD79A
2B cell proliferationGO:0421009.0CD40LG, CD79A

Products for genes affiliated with Sporotrichosis

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Sources for Sporotrichosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet