MCID: SPR010
MIFTS: 51

Sporotrichosis malady

Infectious diseases category

Summaries for Sporotrichosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary systemic mycosis that results in a systemic fungal infection, has material basis in sporothrix schenckii in animals and humans and results in formation of red papule at the site of inoculation.

MalaCards: Sporotrichosis, also known as sporotrichosis, unspecified, is related to syphilis and hairy cell leukemia. An important gene associated with Sporotrichosis is BAG3 (BCL2-associated athanogene 3), and among its related pathways is Primary immunodeficiency. The drugs itraconazole and potassium iodide and the compounds fluconazole and sulfolipid i have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

CDC:3 The page you requested has been moved. Please update your links and bookmarks to the new Sporotrichosis web page.

Wikipedia:63 Sporotrichosis (also known as \"Rose gardener\'s disease\") is a disease caused by the infection of the... more...

Aliases & Classifications for Sporotrichosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
sporotrichosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of death: Normal


Aliases & Descriptions:

sporotrichosis 8 42 10 48 60
sporotrichosis, unspecified 8
rose gardener's disease 42
sporotrichosis nos 8


External Ids:

Disease Ontology8 DOID:14484
MeSH34 D013174
ICD9CM27 117.1
MESH via Orphanet35 D013174
ICD10 via Orphanet26 B42.0, B42.1, B42.7 B42.8, B42.9, more
SNOMED-CT via Orphanet57 42094007
UMLS via Orphanet61 C0038034
ICD1025 B42, B42.9

Related Diseases for Sporotrichosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis30.0CD79A
2hairy cell leukemia30.0ITGAX
3candidiasis29.8CD79A, HTN3
4arthritis10.3
5chromoblastomycosis10.2
6pyoderma gangrenosum10.2
7meningitis10.2
8pyoderma10.2
9acquired immunodeficiency syndrome10.1
10laryngitis10.1
11leishmaniasis10.1
12tuberculosis10.1
13gout10.0
14rosacea10.0
15lymphangitis10.0
16lepromatous leprosy10.0
17secondary syphilis10.0
18blastomycosis10.0
19histoplasmosis10.0
20keratoacanthoma10.0
21leprosy10.0
22leukemia10.0
23osteomyelitis10.0
24sarcoidosis10.0
25sarcoma10.0
26polyclonal hypergammaglobulinemia10.0CD79A
27diphtheria10.0CD79A
28giardiasis10.0CD79A
29cryptosporidiosis10.0CD79A
30gastritis10.0CD79A
31meningoencephalitis10.0CD79A
32dermatitis herpetiformis10.0CD79A
33pemphigus foliaceus10.0CD79A
34q fever10.0CD79A
35brucellosis10.0CD79A
36mumps10.0CD79A
37pyelonephritis10.0CD79A
38macroglobulinemia10.0CD79A
39acute leukemia10.0ITGAX
40cd40 ligand deficiency10.0CD40LG
41guillain-barre syndrome10.0CD40LG
42leptospirosis10.0CD40LG
43herpes simplex10.0CD79A
44congenital toxoplasmosis10.0CD40LG, CD79A
45immunoglobulin g deficiency10.0CD40LG, CD79A
46selective iga deficiency disease10.0CD40LG, CD79A
47immunodeficiency, centromere instability and facial anomalies syndrome10.0CD79A, CD40LG
48immunoglobulin alpha deficiency10.0CD79A, CD40LG
49immunodeficiency with hyper igm type 110.0CD79A, CD40LG
50infectious mononucleosis10.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to sporotrichosis

Clinical Features for Sporotrichosis

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Drugs & Therapeutics for Sporotrichosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sporotrichosis

Drug clinical trials:

Search ClinicalTrials for Sporotrichosis

Search NIH Clinical Center for Sporotrichosis

Search CenterWatch for Sporotrichosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sporotrichosis

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Anatomical Context for Sporotrichosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Sporotrichosis:

32
Skin, Bone, Lung, Brain, Testes, Liver, Breast, Monocytes

Animal Models for Sporotrichosis or affiliated genes

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Publications for Sporotrichosis

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Sources:
50PubMed
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Articles related to Sporotrichosis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Molecular identification of Sporothrix species involved in the first familial outbreak of sporotrichosis in the state of EspA-rito Santo, southeastern Brazil. (24141957)
2013
2
Disseminated Sporotrichosis With Cutaneous and Testicular Involvement. (23746386)
2013
3
Cutaneous tuberculosis simulating lymphocutaneous sporotrichosis. (23157786)
2012
4
Sporotrichosis (Sporothrix schenckii infection) in the New South Wales mid-north coast, 2000-2010. (22621152)
2012
5
Sporotrichosis. (22682194)
2012
6
Sporotrichosis mimicking keratoacanthoma. (22556066)
2012
7
A case series and review of sporotrichosis in Sikkim. (21841306)
2011
8
A recalcitrant facial plaque: fixed cutaneous sporotrichosis. (21342173)
2011
9
Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole. (21864307)
2011
10
Familial occurrence of zoonotic sporotrichosis. (22068790)
2011
11
Disseminated cutaneous sporotrichosis in an immunocompetent individual. (21719337)
2011
12
Invasive candidiasis presenting with multiple subcutaneous nodules mimicking sporotrichosis. (20413374)
2010
13
Sporotrichosis: Part II. (21137636)
2010
14
Histopathology of canine sporotrichosis: a morphological study of 86 cases from Rio de Janeiro (2001-2007). (19360480)
2009
15
Fixed sporotrichosis as a cause of a chronic ulcer on the knee. (19291118)
2009
16
Asteroid body in sporotrichosis. Yeast viability and biological significance within the host immune response. (18608903)
2008
17
A case of atypical sporotrichosis with multifocal cutaneous ulcers. (18076693)
2008
18
Molecular epidemiology and antifungal susceptibility patterns of Sporothrix schenckii isolates from a cat-transmitted epidemic of sporotrichosis in Rio de Janeiro, Brazil. (18324493)
2008
19
Emergence of sporotrichosis in Manipur. (16912444)
2006
20
Sporothrix schenckii and sporotrichosis. (16710567)
2006
21
Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998-2001). (15154732)
2004
22
Sporotrichosis in India: first case in a Delhi resident and an update. (17642967)
2003
23
Phenotyping and genotyping of Sporothrix schenckii isolates according to geographic origin and clinical form of Sporotrichosis. (12149366)
2002
24
Case Report. Bilateral sporotrichosis. (12421294)
2002
25
Sporotrichosis. (12372075)
2002
26
Unsuspected sporotrichosis in childhood. (11332673)
2001
27
The asteroid bodies of sporotrichosis. (9650696)
1998
28
Guess what!. Discoid lupus erythematosus with an unusual clinical appearance mimicking sporotrichosis. (10026015)
1998
29
Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. (8866807)
1996
30
Sporotrichosis. (8821159)
1996
31
Disseminated ulcerated papules and nodules. Cutaneous disseminated sporotrichosis. (8712848)
1996
32
Cutaneous sporotrichosis and distant autoinoculation. (7897030)
1995
33
Itraconazole in the treatment of sporotrichosis: a Korean experience. (7660477)
1995
34
Use of itraconazole for treatment of sporotrichosis involving a knee prosthesis. (8562767)
1995
35
Therapy of sporotrichosis. (8312144)
1993
36
Role of cell-mediated immunity in the resistance to experimental sporotrichosis in mice. (1480205)
1992
37
DNA typing of isolates associated with the 1988 sporotrichosis epidemic. (1352783)
1992
38
Treatment of human cutaneous sporotrichosis with itraconazole. (1335550)
1992
39
Comparison between histochemical and immunohistochemical methods for diagnosis of sporotrichosis. (1479036)
1992
40
Multiple pruritic purple plaques. Cutaneous sporotrichosis. (2024992)
1991
41
Osseous sporotrichosis: CT appearance. Case report. (2059890)
1991
42
Isolation and characterization of Sporothrix schenckii from clinical and environmental sources associated with the largest U.S. epidemic of sporotrichosis. (1864926)
1991
43
Spontaneous remission of cutaneous sporotrichosis--a case report. (1818034)
1991
44
Empyema associated with pulmonary sporotrichosis. (2749363)
1989
45
Sporotrichosis outbreak. (3231395)
1988
46
Sporotrichosis of the knee. A case report. (3960777)
1986
47
Metabolic activity of phagocytes in experimental sporotrichosis. (3012342)
1986
48
Sporotrichosis research in the Transvaal--how it began 60 years ago. (3892731)
1985
49
Application of immunoprecipitation techniques to the diagnosis of cutaneous and extracutaneous forms of sporotrichosis. (6429540)
1984
50
Sporotrichosis of the skin with spontaneous cure--report of a second case. (6826823)
1983

Genetic Variations for Sporotrichosis

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Expression for genes affiliated with Sporotrichosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for genes affiliated with Sporotrichosis

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Sources:
29KEGG
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Pathways related to Sporotrichosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CD79A, CD40LG

Compounds for genes affiliated with Sporotrichosis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Sporotrichosis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1fluconazole44 1110.7CD79A, HTN3
2sulfolipid i449.7CD79A, CD40LG
3sandoglobulin449.7CD40LG, CD79A
4vancomycin44 1110.7CD79A, CD40LG
5pneumococcal449.7CD79A, CD40LG
6blys449.7CD79A, CD40LG
7tuberculin449.7CD40LG, CD79A
8praziquantel44 1110.7CD79A, CD40LG
9hemocyanin449.7CD79A, CD40LG
10gliadin449.7CD79A, CD40LG
11silicone449.7CD40LG, CD79A
12mannan449.7CD79A, CD40LG
13okt3449.6CD40LG, CD79A
14glutaraldehyde449.6CD79A, CD40LG
15sulfasalazine44 28 49 1112.6CD79A, CD40LG
16cardiolipin44 1110.6CD40LG, CD79A
17mycophenolate mofetil44 49 1111.6CD79A, CD40LG
18valproate449.6CD40LG, CD79A
19phenytoin44 49 28 1112.6CD79A, CD40LG
20cytidine44 11 2411.6CD79A, CD40LG
21ivig449.5CD79A, CD40LG
22doxycycline44 1110.5CD40LG, CD79A
23vitamin b12449.5CD79A, CD40LG
24neopterin449.4CD79A, CD40LG
25rituximab44 49 1111.3CD40LG, CD79A
26polyethylene glycol449.3CD79A, CD40LG
27pmma449.3CD79A, CD40LG, HTN3
28anti-fungal449.3CD79A, CD40LG, HTN3
29allergens449.2CD79A, CD40LG
30theophylline44 28 11 2412.0CD79A, CD40LG
31fibrinogen448.8CD79A, CD40LG, ITGAX
32heparin44 28 11 2411.6CD79A, CD40LG, ITGAX

GO Terms for genes affiliated with Sporotrichosis

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Sources:
16Gene Ontology
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Cellular components related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2CD79A, CD40LG, ITGAX
2plasma membraneGO:0058867.6CD79A, CD40LG, BAG3, ITGAX, KCNB1

Biological processes related to Sporotrichosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.3CD79A, CD40LG
2B cell proliferationGO:0421009.0CD79A, CD40LG

Products for genes affiliated with Sporotrichosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sporotrichosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet