MCID: SPR010
MIFTS: 50

Sporotrichosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Sporotrichosis

MalaCards integrated aliases for Sporotrichosis:

Name: Sporotrichosis 12 72 49 55 3 41 14 69
Rose Gardener's Disease 49

Characteristics:

Orphanet epidemiological data:

55
sporotrichosis
Inheritance: Not applicable; Prevalence: >1/1000 (Mexico),1-5/10000 (Peru); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14484
ICD10 32 B42 B42.9
ICD9CM 34 117.1
MeSH 41 D013174
Orphanet 55 ORPHA826
MESH via Orphanet 42 D013174
UMLS via Orphanet 70 C0038034
ICD10 via Orphanet 33 B42.0 B42.1 B42.7 more
UMLS 69 C0038034

Summaries for Sporotrichosis

Disease Ontology : 12 A primary systemic mycosis that results_in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation.

MalaCards based summary : Sporotrichosis, also known as rose gardener's disease, is related to secondary syphilis and meningitis. An important gene associated with Sporotrichosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

Wikipedia : 72 Sporotrichosis (also known as \"rose gardener\'s disease\") is a disease caused by the infection of the... more...

Related Diseases for Sporotrichosis

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 secondary syphilis 30.1 CD40LG CD79A
2 meningitis 30.0 CD40LG IFNG IL10
3 lepromatous leprosy 30.0 IFNG IL10
4 syphilis 30.0 CD40LG CD79A
5 erythema multiforme 29.7 CD79A IFNG
6 candidiasis 29.4 CD79A IFNG IL10
7 acquired immunodeficiency syndrome 29.4 CD40LG CD79A IFNG IL10
8 leprosy 3 29.2 CD40LG CD79A IFNG IL10
9 rheumatoid arthritis 29.0 CD40LG CD79A IFNG IL10
10 acute dacryocystitis 28.8 CALM1 CALM2 CALM3
11 ross river fever 10.4 CD40LG IL10
12 necrotizing ulcerative gingivitis 10.4 CD40LG IL10
13 hyperlucent lung 10.4 IFNG IL10
14 immune suppression 10.4 IFNG IL10
15 cystic echinococcosis 10.4 CD40LG IL10
16 baylisascariasis 10.4 IFNG IL10
17 pericardial tuberculosis 10.4 IFNG IL10
18 tuberculoid leprosy 10.4 IFNG IL10
19 african tick-bite fever 10.4 CD40LG IFNG
20 cat-scratch disease 10.4 CD40LG IFNG
21 chronic active epstein-barr virus infection 10.3 IFNG IL10
22 poliomyelitis 10.3 IFNG IL10
23 fascioliasis 10.3 IFNG IL10
24 multicentric castleman disease 10.3 IFNG IL10
25 hand, foot and mouth disease 10.3 IFNG IL10
26 panuveitis 10.3 CD40LG IL10
27 intermediate uveitis 10.3 IFNG IL10
28 scrub typhus 10.3 CD40LG IL10
29 peanut allergy 10.3 IFNG IL10
30 central nervous system vasculitis 10.3 CD40LG IFNG
31 selective igg deficiency disease 10.3 CD40LG CD79A
32 c1q nephropathy 10.3 CD40LG CD79A
33 eales disease 10.3 IFNG IL10
34 cow milk allergy 10.3 CD79A IL10
35 meningovascular neurosyphilis 10.3 CD40LG CD79A
36 alpha chain disease 10.3 CD40LG CD79A
37 brill-zinsser disease 10.3 CD40LG CD79A
38 aseptic meningitis 10.3 IFNG IL10
39 exudative glomerulonephritis 10.3 CD40LG CD79A
40 cork-handlers' disease 10.3 CD40LG CD79A
41 salpingo-oophoritis 10.3 CD40LG CD79A
42 early yaws 10.3 CD40LG CD79A
43 ventilation pneumonitis 10.3 CD40LG CD79A
44 chronic interstitial cystitis 10.3 CD40LG CD79A
45 axillary adenitis 10.3 CD40LG CD79A
46 cryofibrinogenemia 10.3 CD40LG CD79A
47 trichostrongyloidiasis 10.3 CD40LG CD79A
48 subacute bacterial endocarditis 10.3 CD40LG CD79A
49 heterophyiasis 10.3 CD40LG CD79A
50 immunoglobulin g deficiency 10.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to Sporotrichosis

Symptoms & Phenotypes for Sporotrichosis

Drugs & Therapeutics for Sporotrichosis

Drugs for Sporotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 1, Phase 2 84625-61-6 55283
4 Antifungal Agents Phase 2,Phase 1
5 Anti-Infective Agents Phase 2,Phase 1
6 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
7 Cytochrome P-450 Enzyme Inhibitors Phase 2,Phase 1
8 Hormone Antagonists Phase 2,Phase 1
9 Hormones Phase 2,Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
11 Steroid Synthesis Inhibitors Phase 2,Phase 1
12 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
13 Hydroxyitraconazole Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis Completed NCT00004938 Phase 2 fluconazole
2 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
3 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: sporotrichosis

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

MalaCards organs/tissues related to Sporotrichosis:

38
Skin, Bone, Lung, Brain, Testes, Liver, T Cells

Publications for Sporotrichosis

Articles related to Sporotrichosis:

(show top 50) (show all 609)
# Title Authors Year
1
Successful treatment outcome with itraconazole and potassium iodide in disseminated sporotrichosis. ( 29210361 )
2018
2
Sporotrichosis by<i>Sporothrix schenckii</i>senso stricto with itraconazole resistance and terbinafine sensitivity observed<i>in vitro</i>and<i>in vivo</i>: Case report. ( 29204336 )
2018
3
Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area. ( 29412358 )
2018
4
Sporotrichosis in the nail-An unusual location and presentation. ( 29387746 )
2018
5
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis. ( 29440688 )
2018
6
Disseminated cutaneous sporotrichosis in patient with alcoholism. ( 29340472 )
2017
7
Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission. ( 28103311 )
2017
8
Sporotrichosis in a liver transplant patient: A case report and literature review. ( 28702316 )
2017
9
Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model. ( 29087533 )
2017
10
Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). ( 29080316 )
2017
11
Fungal infection control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosis. ( 28492800 )
2017
12
Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas. ( 29260114 )
2017
13
Disseminated Sporotrichosis with Osteolytic Bone Involvement. ( 28349410 )
2017
14
Successful Treatment of Canine Sporotrichosis with Terbinafine: Case Reports and Literature Review. ( 29222709 )
2017
15
Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy. ( 28846164 )
2017
16
Cutaneous disseminated sporotrichosis: clinical experience of 24 cases. ( 28833587 )
2017
17
Sporotrichosis among children of a hyperendemic area in Peru: an 8-year retrospective study. ( 28488313 )
2017
18
Cavitary Pulmonary Sporotrichosis: Case Report and Literature Review. ( 29058171 )
2017
19
Sporotrichosis masquerading as pyoderma gangrenosum. ( 28627095 )
2017
20
The Current Status of Feline Sporotrichosis in Malaysia. ( 28855477 )
2017
21
Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease. ( 29371525 )
2017
22
Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum. ( 29264381 )
2017
23
Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar. ( 28847419 )
2017
24
Lymphocutaneous Sporotrichosis Treated with Potassium Iodide with Development of Subclinical Hypothyroidism: Wolff-Chaikoff Effect? ( 29204393 )
2017
25
Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count. ( 29147593 )
2017
26
Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis. ( 29033815 )
2017
27
Efficacy of a poly-aggregated formulation of amphotericin B in treating systemic sporotrichosis caused by Sporothrix brasiliensis. ( 28575449 )
2017
28
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics. ( 29166494 )
2017
29
Sporotrichosis: long-term treatment and follow-up in a diabetic patient from Southern Italy. ( 27595209 )
2016
30
In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil. ( 26591009 )
2016
31
Draft Genome Sequence of the Dimorphic Fungus Sporothrix pallida, a Nonpathogenic Species Belonging to Sporothrix, a Genus Containing Agents of Human and Feline Sporotrichosis. ( 27034494 )
2016
32
Sporothrix chilensis sp. nov. (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals. ( 26781380 )
2016
33
Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole. ( 27114300 )
2016
34
Disseminated cutaneous sporotrichosis associated with ocular lesion in an immunocompetent patient. ( 27579758 )
2016
35
Epidemiological investigation of an outbreak of cutaneous sporotrichosis, Northern Territory, Australia. ( 26758905 )
2016
36
Simultaneous onset of sporotrichosis in mother and daughter. ( 27774634 )
2016
37
Refractory sporotrichosis due to Sporothrix brasiliensis in humans appears to be unrelated to in vivo resistance. ( 27771622 )
2016
38
A 27-Year-Old Severely Immunosuppressed Female with Misleading Clinical Features of Disseminated Cutaneous Sporotrichosis. ( 26881148 )
2016
39
Atypical Cutaneous Sporotrichosis in an Immunocompetent Adult: Response to Potassium Iodide. ( 27057047 )
2016
40
Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study. ( 27207412 )
2016
41
MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHOSIS IN PATIENTS WITH HIV/AIDS. ( 26967963 )
2016
42
Sporotrichosis in the Ocular Adnexa: 21 Cases in an Endemic Area in Peru and Review of the Literature. ( 26585212 )
2016
43
A Case of Sporotrichosis Caused by Sporothrix globosa in Japan. ( 27081278 )
2016
44
Clinical features of 10 cases of eyelid sporotrichosis in Jilin Province (Northeast China). ( 27521671 )
2016
45
Sporotrichosis-Associated Hospitalizations, United States, 2000-2013. ( 27648881 )
2016
46
Periungual sporotrichosis: a diagnostic challenge. ( 27062149 )
2016
47
Is There Any Difference between the In Situ and Systemic IL-10 and IFN-I^ Production when Clinical Forms of Cutaneous Sporotrichosis Are Compared? ( 27622513 )
2016
48
Palpebral sporotrichosis in a 6-year-old child. ( 27496011 )
2016
49
Lower percentage of CD8+ T cells in peripheral blood of patients with sporotrichosis. ( 27181291 )
2016
50
Chromoblastomycosis due to Fonsecaea monophora misdiagnosed as sporotrichosis and cutaneous tuberculosis in a pulmonary tuberculosis patient. ( 27330937 )
2016

Variations for Sporotrichosis

Expression for Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for Sporotrichosis

Pathways related to Sporotrichosis according to GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CALM1 CALM2 CALM3 CD40LG CD79A IFNG
2
Show member pathways
13.62 CALM1 CALM2 CALM3 CD40LG IFNG IL10
3
Show member pathways
13.49 CALM1 CALM2 CALM3 CD40LG IFNG IL10
4
Show member pathways
13.4 CALM1 CALM2 CALM3 IFNG IL10
5
Show member pathways
13.32 CALM1 CALM2 CALM3 CD40LG CD79A
6
Show member pathways
13.2 CALM1 CALM2 CALM3 CD40LG IFNG IL10
7
Show member pathways
13.1 CALM1 CALM2 CALM3 CD79A IFNG
8
Show member pathways
12.95 CALM1 CALM2 CALM3 CD79A
9
Show member pathways
12.78 CALM1 CALM2 CALM3 CD79A
10 12.75 CALM1 CALM2 CALM3 IFNG
11
Show member pathways
12.69 CALM1 CALM2 CALM3
12
Show member pathways
12.64 CALM1 CALM2 CALM3 CD79A
13
Show member pathways
12.61 CALM1 CALM2 CALM3 CD40LG
14
Show member pathways
12.54 CALM1 CALM2 CALM3 CD40LG
15
Show member pathways
12.51 CALM1 CALM2 CALM3 CD79A
16 12.48 CD40LG CD79A IFNG IL10
17
Show member pathways
12.46 CALM1 CALM2 CALM3
18
Show member pathways
12.45 CALM1 CALM2 CALM3
19
Show member pathways
12.44 CALM1 CALM2 CALM3
20
Show member pathways
12.43 CALM1 CALM2 CALM3 IFNG
21
Show member pathways
12.41 CALM1 CALM2 CALM3
22
Show member pathways
12.36 CALM1 CALM2 CALM3
23
Show member pathways
12.35 CALM1 CALM2 CALM3
24
Show member pathways
12.34 CALM1 CALM2 CALM3
25
Show member pathways
12.34 CALM1 CALM2 CALM3
26
Show member pathways
12.32 CALM1 CALM2 CALM3
27
Show member pathways
12.31 CALM1 CALM2 CALM3 CD40LG
28
Show member pathways
12.3 CALM1 CALM2 CALM3 CD79A
29
Show member pathways
12.29 CALM1 CALM2 CALM3
30 12.29 CALM1 CALM2 CALM3
31
Show member pathways
12.28 CALM1 CALM2 CALM3
32
Show member pathways
12.27 CALM1 CALM2 CALM3
33
Show member pathways
12.26 CALM1 CALM2 CALM3
34
Show member pathways
12.25 CALM1 CALM2 CALM3
35
Show member pathways
12.25 CALM1 CALM2 CALM3
36
Show member pathways
12.22 CALM1 CALM2 CALM3
37
Show member pathways
12.19 CALM1 CALM2 CALM3
38
Show member pathways
12.19 CD40LG IFNG IL10
39
Show member pathways
12.18 CALM1 CALM2 CALM3
40
Show member pathways
12.18 CALM1 CALM2 CD40LG IFNG IL10
41
Show member pathways
12.17 CALM1 CALM2 CALM3
42
Show member pathways
12.17 CALM1 CALM2 CALM3 IFNG
43
Show member pathways
12.15 CALM1 CALM2 CALM3
44
Show member pathways
12.13 CALM1 CALM2 CALM3
45
Show member pathways
12.12 CALM1 CALM2 CALM3
46
Show member pathways
12.11 CALM1 CALM2 CALM3
47 12.11 CALM1 CALM2 CALM3
48
Show member pathways
12.09 CALM1 CALM2 CALM3
49
Show member pathways
12.06 CALM1 CALM2 CALM3
50 12.03 CALM1 CALM2 CALM3

GO Terms for Sporotrichosis

Cellular components related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.58 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.54 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
5 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
7 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.78 CD40LG CD79A IL10
2 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
3 positive regulation of cAMP biosynthetic process GO:0030819 9.77 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.76 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.75 CALM1 CALM2 CALM3
6 B cell proliferation GO:0042100 9.74 CD40LG CD79A IL10
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.73 CALM1 CALM2 CALM3
8 regulation of cytokinesis GO:0032465 9.72 CALM1 CALM2 CALM3
9 positive regulation of protein autophosphorylation GO:0031954 9.71 CALM1 CALM2 CALM3
10 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
11 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.69 CALM1 CALM2 CALM3
12 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 CALM1 CALM2 CALM3
13 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
14 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.63 CALM1 CALM2 CALM3
15 positive regulation of interleukin-12 production GO:0032735 9.61 CD40LG IFNG
16 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.61 CALM1 CALM2 CALM3
17 detection of calcium ion GO:0005513 9.58 CALM1 CALM2 CALM3
18 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.54 CALM1 CALM2 CALM3
19 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.5 CALM1 CALM2 CALM3
20 positive regulation of protein serine/threonine kinase activity GO:0071902 9.46 CALM1 CALM2 CALM3 IFNG
21 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
22 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
23 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.65 CALM1 CALM2 CALM3
2 cytokine activity GO:0005125 9.63 CD40LG IFNG IL10
3 ion channel binding GO:0044325 9.58 CALM1 CALM2 CALM3
4 disordered domain specific binding GO:0097718 9.54 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.5 CALM1 CALM2 CALM3
6 calcium channel inhibitor activity GO:0019855 9.43 CALM1 CALM2
7 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
8 adenylate cyclase binding GO:0008179 9.33 CALM1 CALM2 CALM3
9 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
10 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Sporotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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