MCID: SPT005
MIFTS: 53

Spotted Fever malady

Rare diseases, Infectious diseases categories
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Summaries for Spotted Fever

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Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary: Spotted Fever, also known as spotted fever group rickettsial disease, is related to mediterranean spotted fever and vascular disease, and has symptoms including An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds dipyrone and gssg have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotype nervous system.

Wikipedia:65 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Aliases & Classifications for Spotted Fever

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Related Diseases for Spotted Fever

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Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Symptoms for Spotted Fever

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Drugs & Therapeutics for Spotted Fever

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Drug clinical trials:

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Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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MalaCards organs/tissues related to Spotted Fever:

32
Skin, Endothelial, Testes, Brain, Liver, Monocytes, T cells, Lymph node, Skeletal muscle, Kidney

FMA organs/tissues related to Spotted Fever:

14
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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MGI Mouse Phenotypes related to Spotted Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1CHKB, G6PD, AFF2, THBD

Publications for Spotted Fever

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Articles related to Spotted Fever:

(show top 50)    (show all 930)
idTitleAuthorsYear
1
Mediterranean Spotted Fever in Children in the Pazardjik Region, South Bulgaria. (24263221)
2013
2
A neonatal case of Japanese spotted fever. (23743544)
2013
3
Mediterranean spotted fever with involvement of the gastrointestinal tract. (23880573)
2013
4
Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais State, Brazil. (23509125)
2013
5
Rickettsioses in the central hills of Sri Lanka: serological evidence of increasing burden of spotted fever group. (23871280)
2013
6
Rapid, simple, and sensitive detection of the ompB gene of spotted fever group rickettsiae by loop-mediated isothermal amplification. (23057497)
2012
7
Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever. (21797105)
2011
8
Coronary involvement in Mediterranean spotted fever. (22143818)
2011
9
Rocky Mountain spotted fever in Panama: a cluster description. (21997944)
2011
10
Dissemination of spotted fever rickettsia agents in Europe by migrating birds. (20052286)
2010
11
Serosurvey of antibodies against spotted fever group Rickettsia spp. in horse farms in Northern ParanA!, Brazil. (21184706)
2010
12
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
13
Rickettsia rickettsii, Rickettsia felis and Rickettsia sp. TwKM03 infecting Rhipicephalus sanguineus and Ctenocephalides felis collected from dogs in a Brazilian spotted fever focus in the State of Rio De Janeiro/Brazil. (19298400)
2009
14
A case of spotted fever group rickettsiosis imported into the United Kingdom and treated with ciprofloxacin: a case report. (18387179)
2008
15
Rocky Mountain spotted fever in Argentina. (18385370)
2008
16
Rocky Mountain spotted fever, Colombia. (18214179)
2007
17
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (17674321)
2007
18
Experimental transmission of Rocky Mountain spotted fever by means of the tick. 1906. (16550763)
2006
19
Human spotted fever rickettsial infections. (15829206)
2005
20
Rocky Mountain Spotted Fever, another important cause of fever and rash. (15498625)
2004
21
Spotted-fever-group rickettsioses in north Asia. (14667766)
2003
22
Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever. (12353892)
2002
23
Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. (12200314)
2002
24
Rocky Mountain spotted fever: a review for the pediatrician. (11905289)
2002
25
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
26
Index of suspicion. Case 2. Rocky Mountain spotted fever. (10208089)
1999
27
Israeli spotted fever rickettsia (Rickettsia conorii complex) associated with human disease in Portugal. (10603225)
1999
28
Rocky mountain spotted fever. (9868640)
1998
29
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. (9866756)
1998
30
Long-term sequelae of Rocky Mountain spotted fever. (7619986)
1995
31
Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. (8143383)
1994
32
Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 1. Clinical and epidemiological features. (1986207)
1991
33
Rocky Mountain spotted fever--United States, 1988. (2501644)
1989
34
Rocky Mountain spotted fever: mimicry of appendicitis or acute surgical abdomen? (3728395)
1986
35
Rocky Mountain spotted fever--United States, 1985. (3083229)
1986
36
Left ventricular dysfunction in Rocky Mountain spotted fever. (6627770)
1983
37
Neurogenic bladder in Rocky Mountain spotted fever. (6824406)
1983
38
Conjunctival hemorrhage and Rocky Mountain spotted fever. (7058380)
1982
39
Rocky mountain spotted fever in dogs and man. (7278854)
1981
40
The occurrence of eschars in Rocky Mountain spotted fever. (7240465)
1981
41
Rocky Mountain Spotted Fever. (7386797)
1980
42
Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. (96691)
1978
43
Rocky Mountain spotted fever in an infant: diagnosis in siblings. (685914)
1978
44
Early diagnosis of Rocky Mountain spotted fever. Use of primary monocyte culture technique. (814256)
1976
45
Rocky Mountain spotted fever: case presentation and general discussion. (1055501)
1975
46
Surveillance of Rocky Mountain spotted fever. (4740658)
1973
47
Anterior nongranulomatous uveitis associated with Rocky Mountain spotted fever. First report of a case. (5774294)
1969
48
HYPOFIBRINOGENEMIA IN ROCKY MOUNTAIN SPOTTED FEVER. REPORT OF A CASE. (14129057)
1964
49
Ecology on Rocky Mountain spotted Fever: a basic research project now in process in Virginia. (13831260)
1961
50
Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever. (18013649)
1933

Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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Expression patterns in normal tissues for genes affiliated with Spotted Fever

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Pathways for genes affiliated with Spotted Fever

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Compounds for genes affiliated with Spotted Fever

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Compounds related to Spotted Fever according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1dipyrone44 1110.8G6PD, CHKB
2gssg449.8CHKB, G6PD
3gemfibrozil28 44 1111.8G6PD, CHKB
4guanidine hydrochloride449.7G6PD, CHKB
5malondialdehyde449.7G6PD, CHKB
6succinate449.7CHKB, G6PD
7uric acid44 2410.7CHKB, G6PD
8carnitine449.7G6PD, CHKB
9glucose 6-phosphate44 2410.7CHKB, G6PD
10alpha tocopherol449.7G6PD, CHKB
11mannitol44 1110.7CHKB, G6PD
12vitamin-e449.5G6PD, THBD
13ptca449.5CHKB, THBD
14glycerol44 24 1111.4CHKB, G6PD
15raloxifene44 50 28 1112.4CHKB, THBD
16fluvastatin44 50 28 1112.4CHKB, THBD
17nifedipine44 28 50 1112.4G6PD, THBD
18neopterin449.4THBD, CHKB
19theophylline44 28 24 1112.4CHKB, THBD
20pravastatin44 50 28 24 1113.4CHKB, THBD
21atorvastatin44 50 28 24 1113.4THBD, CHKB
22prednisolone44 28 1111.3THBD, CHKB
23cyclophosphamide44 50 1111.3G6PD, THBD
24pyruvate449.3CHKB, G6PD
25agarose449.3CHKB, THBD
26valine449.3G6PD, THBD
27simvastatin44 50 61 28 24 1114.3THBD, CHKB
28endotoxin449.2THBD, CHKB
29dmso449.2G6PD, THBD
30phosphatidylserine44 28 1111.1THBD, G6PD
31folate449.1THBD, AFF2, G6PD
32oxygen44 2410.1CCL13, CHKB, G6PD
33phosphatidylcholine449.0G6PD, THBD
34polyethylene glycol449.0CHKB, G6PD, THBD
35azathioprine44 2 50 1112.0CHKB, G6PD, THBD
36citrate449.0CHKB, G6PD, THBD
37thyroxine44 249.9CHKB, G6PD, THBD
38aspirin44 50 28 2411.9CHKB, G6PD, THBD
39ascorbic acid44 249.9THBD, G6PD, CHKB
40lactate448.9CHKB, G6PD, THBD
41creatinine448.9CHKB, G6PD, THBD
42aspartate448.9THBD, G6PD, CHKB
43h2o2448.9THBD, G6PD, CHKB
44steroid448.9THBD, CHKB, CCL13
45dexamethasone44 50 28 1111.9CCL13, CHKB, THBD
46estrogen448.8THBD, G6PD, CHKB
47atp44 289.8CHKB, G6PD, THBD
48nacl448.7CHKB, THBD
49glucose448.7CHKB, G6PD, THBD

GO Terms for genes affiliated with Spotted Fever

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Products for genes affiliated with Spotted Fever

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Sources for Spotted Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet