MCID: SPT005
MIFTS: 52

Spotted Fever malady

Rare diseases, Infectious diseases categories

Summaries for Spotted Fever

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards: Spotted Fever, also known as spotted fevers, is related to mediterranean spotted fever and vascular disease, and has symptoms including maculopapular or petechial rash, muscle aches and fatigue. An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds dipyrone and gssg have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotype nervous system.

Wikipedia:66 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Aliases & Classifications for Spotted Fever

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Related Diseases for Spotted Fever

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Symptoms for Spotted Fever

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9Disease Ontology
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Symptoms:

9
  • maculopapular or petechial rash
  • muscle aches
  • fatigue
  • headache
  • fever

Drugs & Therapeutics for Spotted Fever

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Spotted Fever:

34
Skin, Endothelial, Testes, T cells, Monocytes, Liver, Brain, Kidney, Skeletal muscle, Lymph node

FMA organs/tissues related to Spotted Fever:

15
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Spotted Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1CHKB, G6PD, AFF2, THBD

Publications for Spotted Fever

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53PubMed
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Articles related to Spotted Fever:

(show top 50)    (show all 894)
idTitleAuthorsYear
1
Mediterranean Spotted Fever in Children in the Pazardjik Region, South Bulgaria. (24263221)
2013
2
A neonatal case of Japanese spotted fever. (23743544)
2013
3
Mediterranean spotted fever with involvement of the gastrointestinal tract. (23880573)
2013
4
Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais State, Brazil. (23509125)
2013
5
Rickettsioses in the central hills of Sri Lanka: serological evidence of increasing burden of spotted fever group. (23871280)
2013
6
Rapid, simple, and sensitive detection of the ompB gene of spotted fever group rickettsiae by loop-mediated isothermal amplification. (23057497)
2012
7
Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever. (21797105)
2011
8
Rocky Mountain spotted fever in Panama: a cluster description. (21997944)
2011
9
Dissemination of spotted fever rickettsia agents in Europe by migrating birds. (20052286)
2010
10
Serosurvey of antibodies against spotted fever group Rickettsia spp. in horse farms in Northern ParanA!, Brazil. (21184706)
2010
11
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
12
Rickettsia rickettsii, Rickettsia felis and Rickettsia sp. TwKM03 infecting Rhipicephalus sanguineus and Ctenocephalides felis collected from dogs in a Brazilian spotted fever focus in the State of Rio De Janeiro/Brazil. (19298400)
2009
13
A case of spotted fever group rickettsiosis imported into the United Kingdom and treated with ciprofloxacin: a case report. (18387179)
2008
14
Rocky Mountain spotted fever in Argentina. (18385370)
2008
15
Rocky Mountain spotted fever, Colombia. (18214179)
2007
16
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (17674321)
2007
17
Human spotted fever rickettsial infections. (15829206)
2005
18
Rocky Mountain Spotted Fever, another important cause of fever and rash. (15498625)
2004
19
Spotted-fever-group rickettsioses in north Asia. (14667766)
2003
20
Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever. (12353892)
2002
21
Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. (12200314)
2002
22
Rocky Mountain spotted fever: a review for the pediatrician. (11905289)
2002
23
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
24
Index of suspicion. Case 2. Rocky Mountain spotted fever. (10208089)
1999
25
Israeli spotted fever rickettsia (Rickettsia conorii complex) associated with human disease in Portugal. (10603225)
1999
26
Rocky mountain spotted fever. (9868640)
1998
27
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. (9866756)
1998
28
Long-term sequelae of Rocky Mountain spotted fever. (7619986)
1995
29
Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. (8143383)
1994
30
Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 1. Clinical and epidemiological features. (1986207)
1991
31
Rocky Mountain spotted fever--United States, 1988. (2501644)
1989
32
Rocky Mountain spotted fever: mimicry of appendicitis or acute surgical abdomen? (3728395)
1986
33
Rocky Mountain spotted fever--United States, 1985. (3083229)
1986
34
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
35
Neurogenic bladder in Rocky Mountain spotted fever. (6824406)
1983
36
Conjunctival hemorrhage and Rocky Mountain spotted fever. (7058380)
1982
37
Surveillance of Rocky Mountain spotted fever in the United States, 1978-1980. (7108278)
1982
38
Rocky mountain spotted fever in dogs and man. (7278854)
1981
39
The occurrence of eschars in Rocky Mountain spotted fever. (7240465)
1981
40
Rocky Mountain Spotted Fever. (7386797)
1980
41
Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. (96691)
1978
42
Rocky Mountain spotted fever in an infant: diagnosis in siblings. (685914)
1978
43
Early diagnosis of Rocky Mountain spotted fever. Use of primary monocyte culture technique. (814256)
1976
44
Rocky Mountain spotted fever: case presentation and general discussion. (1055501)
1975
45
Surveillance of Rocky Mountain spotted fever. (4740658)
1973
46
Anterior nongranulomatous uveitis associated with Rocky Mountain spotted fever. First report of a case. (5774294)
1969
47
HYPOFIBRINOGENEMIA IN ROCKY MOUNTAIN SPOTTED FEVER. REPORT OF A CASE. (14129057)
1964
48
Ecology of rocky mountain spotted fever in Western Montana. I. Isolation of Rickettsia rickettsii from wild mammals. (14041199)
1962
49
Ecology on Rocky Mountain spotted Fever: a basic research project now in process in Virginia. (13831260)
1961
50
Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever. (18013649)
1933

Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spotted Fever

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Pathways for genes affiliated with Spotted Fever

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Compounds for genes affiliated with Spotted Fever

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46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Spotted Fever according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1dipyrone46 1210.8G6PD, CHKB
2gssg469.8CHKB, G6PD
3gemfibrozil30 46 1211.8G6PD, CHKB
4guanidine hydrochloride469.7G6PD, CHKB
5malondialdehyde469.7G6PD, CHKB
6succinate469.7CHKB, G6PD
7uric acid46 2510.7CHKB, G6PD
8carnitine469.7G6PD, CHKB
9glucose 6-phosphate46 2510.7CHKB, G6PD
10alpha tocopherol469.7G6PD, CHKB
11mannitol46 1210.7CHKB, G6PD
12vitamin-e469.5G6PD, THBD
13ptca469.5CHKB, THBD
14glycerol46 25 1211.4CHKB, G6PD
15raloxifene46 52 30 1212.4CHKB, THBD
16fluvastatin46 52 30 1212.4CHKB, THBD
17nifedipine46 30 52 1212.4G6PD, THBD
18neopterin469.4THBD, CHKB
19theophylline46 30 25 1212.4CHKB, THBD
20pravastatin46 52 30 25 1213.4CHKB, THBD
21atorvastatin46 52 30 25 1213.4THBD, CHKB
22prednisolone46 30 1211.3THBD, CHKB
23cyclophosphamide46 52 1211.3G6PD, THBD
24pyruvate469.3CHKB, G6PD
25agarose469.3CHKB, THBD
26valine469.3G6PD, THBD
27simvastatin46 52 62 30 25 1214.3THBD, CHKB
28endotoxin469.2THBD, CHKB
29dmso469.2G6PD, THBD
30phosphatidylserine46 30 1211.1THBD, G6PD
31folate469.1THBD, AFF2, G6PD
32oxygen46 2510.1CCL13, CHKB, G6PD
33phosphatidylcholine469.0G6PD, THBD
34polyethylene glycol469.0CHKB, G6PD, THBD
35azathioprine46 3 52 1212.0CHKB, G6PD, THBD
36citrate469.0CHKB, G6PD, THBD
37thyroxine46 259.9CHKB, G6PD, THBD
38aspirin46 52 30 2511.9CHKB, G6PD, THBD
39ascorbic acid46 259.9THBD, G6PD, CHKB
40lactate468.9CHKB, G6PD, THBD
41creatinine468.9CHKB, G6PD, THBD
42aspartate468.9THBD, G6PD, CHKB
43h2o2468.9THBD, G6PD, CHKB
44steroid468.9THBD, CHKB, CCL13
45dexamethasone46 52 30 1211.9CCL13, CHKB, THBD
46estrogen468.8THBD, G6PD, CHKB
47atp46 309.8CHKB, G6PD, THBD
48nacl468.7CHKB, THBD
49glucose468.7CHKB, G6PD, THBD

GO Terms for genes affiliated with Spotted Fever

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Products for genes affiliated with Spotted Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spotted Fever

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet