MCID: SPT005
MIFTS: 49

Spotted Fever malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Spotted Fever

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Summaries for Spotted Fever

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Disease Ontology:10 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary: Spotted Fever, also known as spotted fevers, is related to endotheliitis and hepatitis, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways are OX40 Pathway and Immune response_MIF-mediated glucocorticoid regulation. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:68 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

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Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1endotheliitis31.0CXCL10, TNF
2hepatitis30.6IFNG, IL10, TNF
3appendicitis30.3F2, THBD
4crohn's disease30.2TNF, VWF
5rocky mountain spotted fever11.4
6mediterranean spotted fever11.0
7typhus10.8
8japanese spotted fever10.8
9boutonneuse fever10.6
10flinders island spotted fever10.5
11far eastern spotted fever10.5
12scrub typhus10.4
13q fever10.4
14lyme disease10.4
15ehrlichiosis10.4
16encephalitis10.4
17astrakhan spotted fever10.4
18thrombocytopenia10.3
19endemic typhus10.3
20african tick-bite fever10.3
21indian tick typhus10.3
22rickettsia parkeri spotted fever10.3
23tick infestation10.3
24tularemia10.3
25punctate porokeratosis10.3IL10, TNF
26primary progressive freezing gait10.3IL10, TNF
27microsomia hemifacial radial defects10.3IL10, TNF
28intrapelvic lymph node leukemic reticuloendotheliosis10.3IL10, TNF
29glycogen storage disease viii10.3IL10, TNF
30neurotic excoriation10.3IL10, TNF
31stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.3IFNG, TNF
32autoimmune oophoritis10.3IFNG, TNF
33best1 retinopathy10.3IFNG, TNF
34intermediate anorectal malformation10.3IL10, TNF
35sensorineural hearing loss10.3IFNG, IL10
36colorado tick fever10.3
37rickettsialpox10.3
38queensland tick typhus10.3
39cerebritis10.3
40measles10.3
41epidemic typhus10.3
42myocarditis10.3
43retinitis10.3
44scleroderma10.3IFNG, TNF
45graft-versus-host disease, protection against10.3IFNG, IL10
46fibroepithelial polyp of the anus10.3IL10, TNF
47testicular leukemia10.2IFNG, TNF
48buruli ulcer10.2IFNG, IL10
49pneumonic tularemia10.2IFNG, TNF
50chronic hiccups10.2IFNG, IL10

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Symptoms for Spotted Fever

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Symptoms:

 10
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

Drugs & Therapeutics for Spotted Fever

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Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ampicillinapproved5069-53-46249
Synonyms:
(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
1h8s
33604-21-6
37234-64-3
47355-94-2
50584-05-9
6-(D(-)-alpha-Aminophenylacetamido)penicillanic acid
6-(D-(2-amino-2-Phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
6-(a-Aminophenylacetamido)penicillanic acid
6-D(-)-alpha-Aminophenylacetamido-penicillanic acid
6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9CI
69-52-3 (mono-hydrochloride salt)
69-53-4
6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carbonyl
6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
7177-48-2 (TRIHYDRATE)
800-79-3
8056-87-9
96707-69-6
98520-55-9
A9393_SIGMA
AB-PC
AB-PC Sol
ABPC
AC-14075
AC1L1M46
AMP
AMPI
AMPICILLIN (SEE ALSO AMPICILLIN TRIHYDRATE 7177-48-2)
AP
AY 6108
AY 6108
AY-6108
Acillin
Adobacillin
Alpen
Amblosin
Amcill
Amfipen
Amfipen V
Amfipen v
Aminobenzylpenicillin
Amipenix S
Ampen
Ampi-Co
Ampi-Tab
Ampi-bol
Ampi-co
Ampi-tab
Ampichel
Ampicil
Ampicilina
Ampicilina [INN-Spanish]
Ampicillin
Ampicillin (USP/INN)
Ampicillin A
Ampicillin Acid
Ampicillin Anhydrate
Ampicillin Anhydrous
Ampicillin Base
Ampicillin Sodium
Ampicillin Trihydrate
Ampicillin [USAN:BAN:INN:JAN]
Ampicillin [USAN:INN:BAN:JAN]
Ampicillin [Usan:Ban:Inn:Jan]
Ampicillin acid
Ampicillin anhydrate
Ampicillin sodium
Ampicillina
Ampicillina [DCIT]
Ampicillina [Dcit]
Ampicilline
Ampicilline [INN-French]
Ampicillinum
Ampicillinum [INN-Latin]
Ampicin
Ampifarm
Ampikel
Ampimed
Ampipenin
Ampipenin, nt3
Ampiscel
Ampisyn
Ampivax
Ampivet
Amplacilina
Amplin
Amplipenyl
Amplisom
Amplital
Ampy-Penyl
Anhydrous Ampicillin
Anhydrous ampicillin
Anhydrous ampicillin (JP15)
Austrapen
BA 7305
BIDD:GT0184
BPBio1_000142
BRL 1341
BRL-1341
BSPBio_000128
BSPBio_001862
Bayer 5427
Binotal
Bonapicillin
Britacil
C06574
CHEBI:28971
CHEBI:53713
CHEMBL174
CID6249
Campicillin
Cimex
Copharcilin
D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid
D-(-)-6-(alpha-aminophenylacetamido)penicillanic acid
D-(-)-Ampicillin
D-(-)-alpha-Aminobenzylpenicillin
D-(-)-alpha-Aminopenicillin
D-(-)-ampicillin
D-(−)-6-(α-aminophenylacetamido)penicillanic acid
D-(−)-ampicillin
D-Ampicillin
D-Cillin
D-a-Aminobenzylpenicillin
D00204
DB00415
Delcillin
Deripen
 
DivK1c_000466
Divercillin
Doktacillin
Duphacillin
EINECS 200-709-7
Geocillin
Grampenil
Guicitrina
Guicitrine
HI 63
HMS2090I11
HSDB 3009
IDI1_000466
KBio1_000466
KBio2_000430
KBio2_002998
KBio2_005566
KBio3_001362
KBioGR_000598
KBioSS_000430
KS-R1
LS-1586
LS-169948
Lifeampil
MLS000028405
MLS001074168
Magnapen
Marcillin
MolPort-001-794-635
Morepen
NCGC00023282-05
NCGC00023282-06
NINDS_000466
NSC 528986
NSC-528986
NSC528986
Norobrittin
Novo-ampicillin
Nuvapen
OMNIPEN (AMPICILLIN)
Olin Kid
Olin kid
Omnipen
Omnipen (TN)
Omnipen-N
Orbicilina
P 50
P-50
Pen A
Pen A Oral
Pen Ampil
Pen a
Pen ampil
Penbristol
Penbritin
Penbritin paediatric
Penbritin syrup
Penbritin-S
Penbrock
Penicillin, Aminobenzyl
Penicline
Penimic
Pensyn
Pentrex
Pentrexl
Pentrexyl
Pentritin
Pfizerpen A
Pfizerpen a
Pfizerpen-A
Polycillin
Polycillin-N
Polyflex (Veterinary)
Ponecil
Prestwick0_000114
Prestwick1_000114
Prestwick2_000114
Prestwick3_000114
Princillin
Principen
Principen '125'
Principen '250'
Principen '500'
QIDamp
Qidamp
Racenacillin
Ro-Ampen
Ro-ampen
Rosampline
Roscillin
SBB063111
SK-Ampicillin
SK-ampicillin
SMP1_000211
SMR000058352
SPBio_000818
SPBio_002067
SQ 17382
Semicillin
Semicillin R
Servicillin
Spectrum2_000769
Spectrum3_000301
Spectrum4_000149
Spectrum5_000814
Spectrum_000050
Sumipanto
Supen
Synpenin
Texcillin
Tokiocillin
Tolomol
Totacillin
Totacillin (sodium)
Totacillin-N
Totalciclina
Totapen
Trifacilina
UNII-7C782967RD
Ukapen
Ultrabion
Ultrabron
Vampen
Viccillin
Viccillin S
Vidocillin
Vidopen
WY-5103
Wypicil
alpha-Aminobenzylpenicillin
ampicillanyl
ampicillin
anhydrous ampicillin
2Emetics159

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareRecruitingNCT01431326
2Laboratory Diagnosis of of Rickettsial and Rickettsia-like DiseasesRecruitingNCT01137175
3300 Antibody Diagnostic Test KitEnrolling by invitationNCT01646411

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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MalaCards organs/tissues related to Spotted Fever:

33
Skin, Endothelial, Testes, T cells, Monocytes, Liver, Brain

FMA organs/tissues related to Spotted Fever:

16
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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MGI Mouse Phenotypes related to Spotted Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6F2, IFNG, IL10, THBD, TNF
2MP:00053818.3F2, IFNG, IL10, THBD, TNF, VWF
3MP:00053897.9F2, IDO1, IFNG, IL10, THBD, TNF
4MP:00036317.5CXCL10, F2, IFNG, IL10, THBD, TNF
5MP:00053857.4CXCL10, F2, HTRA1, IFNG, IL10, THBD
6MP:00053847.2CXCL10, F2, IDO1, IFNG, IL10, THBD
7MP:00053766.9CXCL10, F2, IDO1, IFNG, IL10, THBD
8MP:00053876.0CCL5, CXCL10, F2, IDO1, IFNG, IL10
9MP:00053975.8CCL5, CXCL10, F2, IDO1, IFNG, IL10

Publications for Spotted Fever

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Articles related to Spotted Fever:

(show top 50)    (show all 965)
idTitleAuthorsYear
1
National Surveillance of Spotted Fever Group Rickettsioses in the United States, 2008-2012. (26324732)
2015
2
Spotted fever group rickettsiae detected in immature stages of ticks parasitizing on Iberian endemic lizard Lacerta schreiberi Bedriaga, 1878. (26141751)
2015
3
Teaching NeuroImages: Starry-sky appearance in Rocky Mountain spotted fever. (26391418)
2015
4
Expanding Range of Amblyomma americanum and Simultaneous Changes in the Epidemiology of Spotted Fever Group Rickettsiosis in the United States. (26503270)
2015
5
Assessment of prevalence and distribution of spotted fever group rickettsiae in Manitoba, Canada, in the American dog tick, Dermacentor variabilis (Acari: Ixodidae). (25700040)
2015
6
Urbanization of Brazilian spotted fever in a municipality of the southeastern region: epidemiology and spatial distribution. (26083504)
2015
7
Mediterranean Spotted Fever in Children in the Pazardjik Region, South Bulgaria. (24263221)
2013
8
A neonatal case of Japanese spotted fever. (23743544)
2013
9
Mediterranean spotted fever with involvement of the gastrointestinal tract. (23880573)
2013
10
Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais State, Brazil. (23509125)
2013
11
Rapid, simple, and sensitive detection of the ompB gene of spotted fever group rickettsiae by loop-mediated isothermal amplification. (23057497)
2012
12
Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever. (21797105)
2011
13
Coronary involvement in Mediterranean spotted fever. (22143818)
2011
14
Rocky Mountain spotted fever in Panama: a cluster description. (21997944)
2011
15
Dissemination of spotted fever rickettsia agents in Europe by migrating birds. (20052286)
2010
16
Serosurvey of antibodies against spotted fever group Rickettsia spp. in horse farms in Northern ParanA!, Brazil. (21184706)
2010
17
A case of spotted fever group rickettsiosis imported into the United Kingdom and treated with ciprofloxacin: a case report. (18387179)
2008
18
Rocky Mountain spotted fever in Argentina. (18385370)
2008
19
Rocky Mountain spotted fever, Colombia. (18214179)
2007
20
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (17674321)
2007
21
Experimental transmission of Rocky Mountain spotted fever by means of the tick. 1906. (16550763)
2006
22
Human spotted fever rickettsial infections. (15829206)
2005
23
Rocky Mountain Spotted Fever, another important cause of fever and rash. (15498625)
2004
24
Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever. (12353892)
2002
25
Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. (12200314)
2002
26
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
27
Index of suspicion. Case 2. Rocky Mountain spotted fever. (10208089)
1999
28
Israeli spotted fever rickettsia (Rickettsia conorii complex) associated with human disease in Portugal. (10603225)
1999
29
Rocky mountain spotted fever. (9868640)
1998
30
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. (9866756)
1998
31
Long-term sequelae of Rocky Mountain spotted fever. (7619986)
1995
32
Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. (8143383)
1994
33
Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 1. Clinical and epidemiological features. (1986207)
1991
34
Rocky Mountain spotted fever--United States, 1988. (2501644)
1989
35
Rocky Mountain spotted fever: mimicry of appendicitis or acute surgical abdomen? (3728395)
1986
36
Rocky Mountain spotted fever--United States, 1985. (3083229)
1986
37
Left ventricular dysfunction in Rocky Mountain spotted fever. (6627770)
1983
38
Neurogenic bladder in Rocky Mountain spotted fever. (6824406)
1983
39
Conjunctival hemorrhage and Rocky Mountain spotted fever. (7058380)
1982
40
Surveillance of Rocky Mountain spotted fever in the United States, 1978-1980. (7108278)
1982
41
Rocky mountain spotted fever in dogs and man. (7278854)
1981
42
The occurrence of eschars in Rocky Mountain spotted fever. (7240465)
1981
43
Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. (96691)
1978
44
Rocky Mountain spotted fever in an infant: diagnosis in siblings. (685914)
1978
45
Early diagnosis of Rocky Mountain spotted fever. Use of primary monocyte culture technique. (814256)
1976
46
Rocky Mountain spotted fever: case presentation and general discussion. (1055501)
1975
47
Surveillance of Rocky Mountain spotted fever. (4740658)
1973
48
Anterior nongranulomatous uveitis associated with Rocky Mountain spotted fever. First report of a case. (5774294)
1969
49
Ecology on Rocky Mountain spotted Fever: a basic research project now in process in Virginia. (13831260)
1961
50
Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever. (18013649)
1933

Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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Search GEO for disease gene expression data for Spotted Fever.

Pathways for genes affiliated with Spotted Fever

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Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, IL10
29.7IFNG, TNF
39.4IFNG, IL10, TNF
4
Show member pathways
9.4IFNG, IL10, TNF
5
Show member pathways
9.4IFNG, IL10, TNF
6
Show member pathways
9.4IFNG, IL10, TNF
79.4IFNG, IL10, TNF
89.4IFNG, IL10, TNF
9
Show member pathways
9.4IFNG, IL10, TNF
109.4IFNG, IL10, TNF
119.2CCL5, TNF
12
Show member pathways
9.2CXCL10, IFNG, TNF
139.2CXCL10, IFNG, TNF
14
Show member pathways
9.1F2, IFNG, TNF
15
Show member pathways
9.0F2, THBD, VWF
168.9CCL5, IFNG, TNF
178.9IDO1, IFNG, IL10, TNF
18
Show member pathways
8.8F2, IFNG, IL10, TNF
198.7CCL5, CXCL10, TNF
20
Show member pathways
8.5CXCL10, F2, THBD, VWF
21
Show member pathways
8.4CCL5, CXCL10, IFNG, TNF
22
Show member pathways
8.1CCL5, CXCL10, IFNG, IL10, TNF
237.5CCL5, CXCL10, IDO1, IFNG, IL10, TNF

GO Terms for genes affiliated with Spotted Fever

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Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2CXCL10, IFNG, TNF, VWF
2extracellular matrixGO:00310129.0F2, HTRA1, VWF
3extracellular spaceGO:00056156.8CCL5, CXCL10, F2, HTRA1, IFNG, IL10
4extracellular regionGO:00055766.7CCL5, CXCL10, F2, HTRA1, IFNG, TNF

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.4IFNG, TNF
2positive regulation of MHC class II biosynthetic processGO:004534810.4IFNG, IL10
3receptor biosynthetic processGO:003280010.4IL10, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:006055910.4IFNG, TNF
5negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
6positive regulation of chemokine biosynthetic processGO:004508010.3IFNG, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IFNG, TNF
8positive regulation of cytokine secretionGO:005071510.3IL10, TNF
9defense response to protozoanGO:004283210.3IFNG, IL10
10protein import into nucleus, translocationGO:000006010.3IFNG, TNF
11negative regulation of interleukin-6 productionGO:003271510.3IL10, TNF
12response to inactivityGO:001485410.2F2, IL10
13positive regulation of interleukin-12 productionGO:003273510.1IDO1, IFNG
14negative regulation of fibrinolysisGO:005191810.1F2, THBD
15negative regulation of platelet activationGO:001054410.1F2, THBD
16blood coagulation, intrinsic pathwayGO:000759710.0F2, VWF
17negative regulation of myoblast differentiationGO:004566210.0CXCL10, TNF
18negative regulation of growth of symbiont in hostGO:00441309.9IFNG, IL10, TNF
19response to salt stressGO:00096519.8CCL5, TNF
20positive regulation of fever generationGO:00316229.8CCL5, TNF
21lipopolysaccharide-mediated signaling pathwayGO:00316639.8CCL5, TNF
22positive regulation of release of sequestered calcium ion into cytosolGO:00512819.8CXCL10, F2
23positive regulation of JAK-STAT cascadeGO:00464279.8CCL5, IL10
24positive regulation of T cell apoptotic processGO:00702349.7CCL5, IDO1
25positive regulation of monocyte chemotaxisGO:00900269.6CCL5, CXCL10
26positive regulation of T cell migrationGO:20004069.6CCL5, CXCL10
27regulation of insulin secretionGO:00507969.4CCL5, IFNG, TNF
28defense response to bacteriumGO:00427429.4IFNG, IL10, TNF
29leukocyte migrationGO:00509009.4F2, THBD, TNF
30response to glucocorticoidGO:00513849.4CCL5, IL10, TNF
31positive regulation of osteoclast differentiationGO:00456729.3CCL5, IFNG, TNF
32negative regulation of T cell apoptotic processGO:00702339.1CCL5, IDO1
33positive regulation of cell adhesionGO:00457859.1CCL5, IFNG, TNF
34cell surface receptor signaling pathwayGO:00071668.9CXCL10, F2, IFNG, TNF
35cellular response to lipopolysaccharideGO:00712228.4CCL5, CXCL10, IFNG, IL10, TNF
36response to lipopolysaccharideGO:00324968.3CCL5, CXCL10, IDO1, IL10, THBD
37immune responseGO:00069558.2CCL5, CXCL10, IFNG, IL10, TNF
38inflammatory responseGO:00069548.2CCL5, CXCL10, IDO1, IL10, TNF
39response to virusGO:00096158.1CCL5, CXCL10, IFNG, TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.4IFNG, IL10, TNF

Sources for Spotted Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet