MCID: SPT005
MIFTS: 55

Spotted Fever malady

Infectious diseases category

Summaries for Spotted Fever

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards: Spotted Fever, also known as spotted fevers, is related to typhus and japanese spotted fever, and has symptoms including maculopapular or petechial rash, muscle aches and fatigue. An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds rantes and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotype nervous system.

Wikipedia:63 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Aliases & Classifications for Spotted Fever

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Spotted Fever

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Clinical Features for Spotted Fever

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8Disease Ontology
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Symptoms:

8
  • maculopapular or petechial rash
  • muscle aches
  • fatigue
  • headache
  • fever

Drugs & Therapeutics for Spotted Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Spotted Fever

Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Spotted Fever:

32
Skin, Endothelial, Testes, T cells, Monocytes, Liver, Brain, Kidney, Skeletal muscle, Lymph node

FMA organs/tissues related to Spotted Fever:

14
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spotted Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.9SLC17A5, THBD, CXCL10, CHKB, AFF2, YAP1

Publications for Spotted Fever

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50PubMed
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Articles related to Spotted Fever:

(show top 50)    (show all 911)
idTitleAuthorsYear
1
In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. (23363571)
2013
2
A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. (22541336)
2012
3
Spotted fever group Rickettsia infecting ticks (Acari: Ixodidae) in the state of Santa Catarina, Brazil. (22241112)
2011
4
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? (21091673)
2010
5
Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases). (20102497)
2010
6
Topical treatment with incision and antiseptic may prevent the severity of Japan spotted fever. (20883373)
2010
7
Rocky Mountain spotted fever in dogs, Brazil. (19239764)
2009
8
Spotted fever group rickettsioses documented in Morocco. (23734584)
2009
9
Splenic rupture and malignant Mediterranean spotted fever. (18507929)
2008
10
Spotted fever group rickettsiae in ticks, Morocco. (18598627)
2008
11
Mediterranean spotted fever: presentation with pancytopenia. (16823824)
2006
12
Detection and identification of a novel spotted fever group rickettsia in Western Australia. (17114708)
2006
13
Severe Japanese spotted fever successfully treated with fluoroquinolone. (17170509)
2006
14
Human spotted fever rickettsial infections. (15829206)
2005
15
The presence of eschars, but not greater severity, in Portuguese patients infected with Israeli spotted fever. (16481514)
2005
16
Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of SALo Paulo, Brazil, where Brazilian spotted fever is endemic. (14715737)
2004
17
Fatal cases of Rocky Mountain spotted fever in family clusters--three states, 2003. (15152183)
2004
18
Rocky Mountain Spotted Fever as a cause of macular star figure. (14663310)
2003
19
Detection of antibodies against spotted fever group Rickettsia (SFGR), typhus group Rickettsia (TGR), and Coxiella burnetii in human febrile patients in the Philippines. (12711823)
2003
20
Characterization of spotted fever group rickettsiae detected in dogs and ticks in Okinawa, Japan. (12061628)
2002
21
Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis. (11738766)
2001
22
Japanese spotted fever cases in Kochi prefecture. (10777859)
2000
23
Detection and identification of the aetiological agent of Mediterranean spotted fever (MSF) in two genera of ticks in Cyprus. (10717741)
1999
24
Rocky Mountain spotted fever research at Wake Forest University School of Medicine. Harrell's miracle on Hawthorne Hill. (9785909)
1998
25
Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA. (9734038)
1998
26
Detection of a spotted fever group rickettsia in Amblyomma cajennense (Acari: Ixodidae) in south Texas. (9701930)
1998
27
Rickettsiae-infected ticks in an endemic area of spotted fever in the State of Minas Gerais, Brazil. (9361740)
1997
28
Remember Rocky Mountain spotted fever--a lesson in ethical principles. (8816146)
1996
29
Long-term sequelae of Rocky Mountain spotted fever. (7619986)
1995
30
Rocky Mountain spotted fever: a seasonal alert. (7619984)
1995
31
The use of a polymerase chain reaction as a diagnostic test for Rocky Mountain spotted fever. (8304573)
1994
32
Some aspects of Rocky Mountain spotted fever as shown by recent investigations. 1909. (1775857)
1991
33
Treatment of Rocky Mountain spotted fever. (1865296)
1991
34
Tetracycline for Rocky Mountain spotted fever. (1984610)
1991
35
Rocky Mountain spotted fever in Texas, 1978 through 1987. (2588182)
1989
36
Rocky Mountain spotted fever. (2755520)
1989
37
Serological evidence of subclinical Rocky Mountain spotted fever infections in Texas. (3918125)
1985
38
Hyponatremia in Rocky Mountain spotted fever: role of antidiuretic hormone. (6830077)
1983
39
Cutaneous leukocytoclastic vasculitis in the rose spot of paratyphoid fever. (6807856)
1982
40
Rocky Mountain spotted fever in a dog. (7056658)
1982
41
Rocky Mountain spotted fever--United States, 1981. (6808344)
1982
42
Adult respiratory distress syndrome in Rocky Mountain spotted fever. (7235377)
1981
43
Rocky Mountain spotted fever in Mississippi: an update on an increasingly common infection. (7253013)
1981
44
Detection of the Rocky Mountain spotted fever agent, Rickettsia rickettsii, in dead ticks, Dermacentor andersoni. (97233)
1978
45
Rocky Mountain spotted fever: epidemiology of an increasing problem. (937888)
1976
46
Prompt confirmation of Rocky Mountain spotted fever: identification of rickettsiae in skin tissues. (824374)
1976
47
Massachusetts Department of Public Health. On the alert for Rocky Mountain Spotted Fever. (1128559)
1975
48
Rocky Mountain spotted fever in Virginia: clinical and epidemiologic features. (5533618)
1970
49
Rocky mountain spotted fever in the eastern United States. (4881723)
1969
50
Retinopathy in Rocky Mountain spotted fever. (5793664)
1969

Genetic Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spotted Fever

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Pathways for genes affiliated with Spotted Fever

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Compounds for genes affiliated with Spotted Fever

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Spotted Fever according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1rantes4410.5IDO1
2alpha-hydroxybutyrate4410.5SLC17A5, CHKB
3dipyrone44 1111.5CHKB, G6PD
4thiobarbituric acid4410.4SLC17A5, G6PD
5malondialdehyde4410.3G6PD, CHKB, SLC17A5
6succinylcholine44 28 1112.3SLC17A5, CHKB
7ribavirin44 49 1112.2G6PD, CXCL10, SLC17A5
8polyethylene glycol4410.2G6PD, CHKB, THBD, SLC17A5
9uric acid44 2411.2G6PD, CHKB, SLC17A5
10dexamethasone44 49 28 1113.2CCL13, IDO1, CXCL9
11folate4410.2SLC17A5, THBD, AFF2, G6PD
12thyroxine44 2411.2SLC17A5, THBD, CHKB, G6PD
13carnitine4410.2SLC17A5, CHKB, G6PD
14tarc4410.2CCL13, CXCL10, CXCL9
15triiodothyronine4410.2SLC17A5, KHDRBS3, CHKB
16vitamin-e4410.1SLC17A5, THBD, G6PD, IDO1
17zinc protoporphyrin4410.1G6PD, SLC17A5
18ccl444 2811.1CXCL10, CXCL9, SLC17A5
19ascorbic acid44 2411.1G6PD, CHKB, THBD, SLC17A5
20azathioprine44 49 2 1113.1G6PD, CHKB, THBD
21beta-hydroxybutyrate4410.0CHKB, SLC17A5
22quinine44 28 2 1113.0SLC17A5, CXCL9, G6PD, IDO1
23prednisolone44 28 1112.0SLC17A5, THBD, CHKB
24neopterin449.9SLC17A5, THBD, CXCL10, CHKB, IDO1
25endotoxin449.9CHKB, CXCL10, CXCL9, THBD, SLC17A5
26h2o2449.9HTRA1, G6PD, CHKB, THBD, SLC17A5
27histamine44 28 2411.7CCL13, PPP1R14A, CXCL10, CXCL9, THBD
28creatinine449.7G6PD, CHKB, CXCL10, CXCL9, THBD, SLC17A5
29atorvastatin44 49 28 11 2413.7SLC17A5, THBD, CHKB
30alanine449.7SLC17A5, THBD, KHDRBS3, CXCL10, CHKB, HTRA1
31nitric oxide44 11 2411.6SLC17A5, THBD, CXCL9, CXCL10, CHKB, IDO1
32glucose449.5IRS4, G6PD, CHKB, CXCL10, THBD, SLC17A5
33atp44 2810.5G6PD, CHKB, CXCL10, CXCL9, THBD, SLC17A5
34tyrosine449.1IDO1, IRS4, YAP1, CXCL10, CXCL9, KHDRBS3

GO Terms for genes affiliated with Spotted Fever

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16Gene Ontology
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Biological processes related to Spotted Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:0069359.8CXCL9, CXCL10, CCL13

Molecular functions related to Spotted Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL9, CXCL10, CCL13

Products for genes affiliated with Spotted Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spotted Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet