MCID: SPT005
MIFTS: 51

Spotted Fever malady

Infectious category

Summaries for Spotted Fever

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards: Spotted Fever, also known as spotted fevers, is related to typhus and japanese spotted fever, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds rantes and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and liver, and related mouse phenotype nervous system.

Wikipedia:64 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Aliases & Classifications for Spotted Fever

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Spotted Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Clinical Features for Spotted Fever

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 5)
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

Drugs & Therapeutics for Spotted Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spotted Fever

Drug clinical trials:

Search ClinicalTrials for Spotted Fever

Search NIH Clinical Center for Spotted Fever

Search CenterWatch for Spotted Fever

Genetic Tests for Spotted Fever

Anatomical Context for Spotted Fever

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Spotted Fever:

33
Skin, Liver, Brain, Kidney, Lymph node, Skeletal muscle, Monocytes, T cells, B cells, Endothelial

FMA organs/tissues related to Spotted Fever:

14
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Spotted Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.9SLC17A5, THBD, CXCL10, CHKB, AFF2, YAP1

Publications for Spotted Fever

Sources:
51PubMed
See all sources

Articles related to Spotted Fever:

(show top 50)    (show all 909)
idTitleAuthorsYear
1
Seroreactivity for spotted fever rickettsiae and co-infections with other tick-borne agents among habitants in central and southern Sweden. (22961007)
2013
2
Gangrene in cases of spotted fever: a report of three cases. (23257640)
2012
3
Trends in clinical diagnoses of Rocky Mountain spotted fever among American Indians, 2001-2008. (22232466)
2012
4
Afebrile spotted fever group Rickettsia infection after a bite from a Dermacentor variabilis tick infected with Rickettsia montanensis. (23153005)
2012
5
Infrequency of Rickettsia rickettsii in Dermacentor variabilis removed from humans, with comments on the role of other human-biting ticks associated with spotted fever group Rickettsiae in the United States. (21142953)
2011
6
The occurrence of spotted fever rickettsioses and other tick-borne infections in forest workers in Poland. (21083370)
2011
7
Dose-response model of Rocky Mountain spotted fever (RMSF) for human. (21453373)
2011
8
Nine cases of Japan spotted fever diagnosed at our hospital in 2008. (20465700)
2010
9
Adult Onset Still's Disease and Rocky Mountain Spotted Fever. (20811570)
2010
10
A case of acute quadriplegia complicating Mediterranean spotted fever. (17382465)
2007
11
Experimental transmission of Rocky Mountain spotted fever by means of the tick. 1906. (16550763)
2006
12
Mediterranean spotted fever: a review of fifteen cases. (16556276)
2006
13
Japanese spotted fever, South Korea. (16836831)
2006
14
Rickettsiae of the spotted-fever group in ixodid ticks from Hungary: identification of a new genotype ('Candidatus Rickettsia kotlanii'). (16630380)
2006
15
Fatal spotted fever rickettsiosis, Kenya. (15200829)
2004
16
Spotted-fever-group rickettsioses in north Asia. (14667766)
2003
17
Identification of Borrelia burgdorferi sensu lato, Anaplasma and Ehrlichia species, and spotted fever group Rickettsiae in ticks from Southeastern Europe. (12938010)
2003
18
Rickettsia honei: a spotted fever group Rickettsia on three continents. (12860601)
2003
19
Brazilian spotted fever: description of a fatal clinical case in the State of Rio de Janeiro. (12621675)
2002
20
Identification of Ctenocephalides felis fleas as a host of Rickettsia felis, the agent of a spotted fever rickettsiosis in YucataA8, Mexico. (12653300)
2002
21
Human monocytic ehrlichiosis: similar to Rocky Mountain spotted fever but different. (11905291)
2002
22
Detection and identification of spotted fever group Rickettsiae and Ehrlichiae in African ticks. (11747731)
2001
23
Interspecific differences between small mammals as hosts of immature Dermacentor variabilis (Acari: Ixodidae) and a model for detection of high risk areas of Rocky Mountain spotted fever. (8885876)
1996
24
Photo quiz. Rocky Mountain Spotted Fever. (8562737)
1995
25
Epidemiology of Rocky Mountain spotted fever in South Carolina, 1985-1990. (1518284)
1992
26
Acute glomerulonephritis in a patient with Rocky Mountain spotted fever. (1996579)
1991
27
Rocky Mountain spotted fever. When and why to consider the diagnosis. (2315240)
1990
28
Meningoencephalitis as a major manifestation of Rocky Mountain spotted fever. (3393952)
1988
29
A focus of Rocky Mountain spotted fever within New York City. (3130574)
1988
30
The sensitivity of various serologic tests in the diagnosis of Rocky Mountain spotted fever. (3089042)
1986
31
Rocky Mountain spotted fever mimicking acute cholecystitis. (4074033)
1985
32
Epidemiology of Rocky Mountain spotted fever as determined by active surveillance. (6491364)
1984
33
Neurogenic bladder in Rocky Mountain spotted fever. (6824406)
1983
34
Rocky Mountain spotted fever vaccine in an animal model. (6413529)
1983
35
Rocky Mountain spotted fever--United States, 1982. (6405162)
1983
36
Rocky Mountain spotted fever in the United States: use of age-specific incidence to determine public health policy for a vector-borne disease. (7054878)
1982
37
Rocky Mountain spotted fever in areas of high and low prevalence: survey for canine antibodies to spotted fever rickettsiae. (6808878)
1982
38
Perspectives in Rocky Mountain spotted fever; early diagnosis and management. (7241264)
1981
39
Measles in patients suspected of having Rocky Mountain spotted fever. (6771427)
1980
40
Rocky Mountain spotted fever in an infant: diagnosis in siblings. (685914)
1978
41
Rocky Mountain spotted fever in Northwest Arkansas. (143470)
1977
42
Pathogenesis of infection with Rickettsia rickettsii in the dog: a disease model for Rocky Mountain spotted fever. (405432)
1977
43
Rocky Mountain spotted fever. (1044493)
1976
44
Changes in plasma could-insoluble globulin concentration during experimental Rocky Mountain spotted fever infection in rhesus monkeys. (822532)
1976
45
Rocky Mountain spotted fever in three brothers. (4511960)
1973
46
ROCKY MOUNTAIN SPOTTED FEVER: A SAGA OF THE LAND OF LINCOLN. (14289294)
1965
47
Evaluation of the fluorescent antibody technique for the detection of Rocky Mountain spotted fever rickettsiae in various tissues. (13688986)
1961
48
Fluorescent antibody staining as a means of detecting Rocky Mountain spotted fever infection in individual ticks. (14445822)
1960
49
Changes in the tissue radiosodium space associated with experimental Rocky Mountain spotted fever in guinea pigs. (13109241)
1953
50
Clinical aspects of rickettsialpox, Q. fever and Rocky Mountain spotted fever. (18142749)
1949

Genetic Variations for Spotted Fever

Expression for genes affiliated with Spotted Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spotted Fever

Search GEO for disease gene expression data for Spotted Fever.

Pathways for genes affiliated with Spotted Fever

Compounds for genes affiliated with Spotted Fever

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Spotted Fever according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1rantes4510.5IDO1
2alpha-hydroxybutyrate4510.5SLC17A5, CHKB
3dipyrone45 1111.5G6PD, CHKB
4thiobarbituric acid4510.4SLC17A5, G6PD
5malondialdehyde4510.3CHKB, SLC17A5, G6PD
6succinylcholine45 29 1112.3CHKB, SLC17A5
7ribavirin45 50 1112.2G6PD, SLC17A5, CXCL10
8polyethylene glycol4510.2G6PD, SLC17A5, THBD, CHKB
9uric acid45 2411.2SLC17A5, CHKB, G6PD
10dexamethasone45 50 29 1113.2CCL13, IDO1, CXCL9
11folate4510.2G6PD, THBD, AFF2, SLC17A5
12thyroxine45 2411.2THBD, CHKB, G6PD, SLC17A5
13carnitine4510.2SLC17A5, G6PD, CHKB
14tarc4510.2CXCL9, CXCL10, CCL13
15triiodothyronine4510.2SLC17A5, KHDRBS3, CHKB
16vitamin-e4510.1IDO1, THBD, G6PD, SLC17A5
17beta-hydroxybutyrate4510.1CHKB, SLC17A5
18ccl445 2911.1SLC17A5, CXCL9, CXCL10
19ascorbic acid45 2411.1CHKB, THBD, G6PD, SLC17A5
20azathioprine45 50 2 1113.1THBD, G6PD, CHKB
21zinc protoporphyrin4510.0SLC17A5, G6PD
22quinine45 29 2 1113.0IDO1, G6PD, CXCL9, SLC17A5
23prednisolone45 29 1112.0THBD, CHKB, SLC17A5
24neopterin459.9SLC17A5, IDO1, CHKB, CXCL10, THBD
25endotoxin459.9CXCL10, SLC17A5, THBD, CXCL9, CHKB
26h2o2459.9G6PD, CHKB, THBD, HTRA1, SLC17A5
27histamine45 29 2411.7PPP1R14A, CCL13, CXCL9, CXCL10, THBD
28creatinine459.7G6PD, CHKB, CXCL10, CXCL9, SLC17A5, THBD
29atorvastatin45 50 29 11 2413.7SLC17A5, CHKB, THBD
30alanine459.7HTRA1, CHKB, CXCL10, KHDRBS3, SLC17A5, THBD
31nitric oxide45 11 2411.6THBD, CXCL9, CXCL10, CHKB, IDO1, SLC17A5
32glucose459.5CXCL10, CHKB, THBD, SLC17A5, G6PD, IRS4
33atp45 2910.5THBD, CHKB, G6PD, SLC17A5, CXCL10, CXCL9
34tyrosine459.1IRS4, YAP1, THBD, SLC17A5, KHDRBS3, CXCL9

GO Terms for genes affiliated with Spotted Fever

Sources:
16Gene Ontology
See all sources

Biological processes related to Spotted Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:0069359.8CXCL9, CXCL10, CCL13

Molecular functions related to Spotted Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL9, CXCL10, CCL13

Products for genes affiliated with Spotted Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spotted Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet