MCID: SPT005
MIFTS: 45

Spotted Fever malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Spotted Fever

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Summaries for Spotted Fever

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Disease Ontology:9 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary: Spotted Fever, also known as spotted fevers, is related to mediterranean spotted fever and vascular disease, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds dipyrone and gssg have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotype nervous system.

Wikipedia:63 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

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Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Symptoms for Spotted Fever

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Symptoms:

 9
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

Drugs & Therapeutics for Spotted Fever

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Drug clinical trials:

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Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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MalaCards organs/tissues related to Spotted Fever:

31
Skin, Endothelial, Testes, Brain, Liver, T cells, Lymph node, Skeletal muscle, Kidney, Monocytes

FMA organs/tissues related to Spotted Fever:

14
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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MGI Mouse Phenotypes related to Spotted Fever:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1CHKB, G6PD, AFF2, THBD

Publications for Spotted Fever

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Articles related to Spotted Fever:

(show top 50)    (show all 940)
idTitleAuthorsYear
1
Assessment of prevalence and distribution of spotted fever group rickettsiae in Manitoba, Canada, in the American dog tick, Dermacentor variabilis (Acari: Ixodidae). (25700040)
2015
2
Mediterranean Spotted Fever in Children in the Pazardjik Region, South Bulgaria. (24263221)
2013
3
A neonatal case of Japanese spotted fever. (23743544)
2013
4
Mediterranean spotted fever with involvement of the gastrointestinal tract. (23880573)
2013
5
Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais State, Brazil. (23509125)
2013
6
Rickettsioses in the central hills of Sri Lanka: serological evidence of increasing burden of spotted fever group. (23871280)
2013
7
Rapid, simple, and sensitive detection of the ompB gene of spotted fever group rickettsiae by loop-mediated isothermal amplification. (23057497)
2012
8
Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever. (21797105)
2011
9
Coronary involvement in Mediterranean spotted fever. (22143818)
2011
10
Rocky Mountain spotted fever in Panama: a cluster description. (21997944)
2011
11
Dissemination of spotted fever rickettsia agents in Europe by migrating birds. (20052286)
2010
12
Serosurvey of antibodies against spotted fever group Rickettsia spp. in horse farms in Northern ParanA!, Brazil. (21184706)
2010
13
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
14
Rickettsia rickettsii, Rickettsia felis and Rickettsia sp. TwKM03 infecting Rhipicephalus sanguineus and Ctenocephalides felis collected from dogs in a Brazilian spotted fever focus in the State of Rio De Janeiro/Brazil. (19298400)
2009
15
A case of spotted fever group rickettsiosis imported into the United Kingdom and treated with ciprofloxacin: a case report. (18387179)
2008
16
Rocky Mountain spotted fever in Argentina. (18385370)
2008
17
Rocky Mountain spotted fever, Colombia. (18214179)
2007
18
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (17674321)
2007
19
Experimental transmission of Rocky Mountain spotted fever by means of the tick. 1906. (16550763)
2006
20
Human spotted fever rickettsial infections. (15829206)
2005
21
Rocky Mountain Spotted Fever, another important cause of fever and rash. (15498625)
2004
22
Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever. (12353892)
2002
23
Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. (12200314)
2002
24
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
25
Index of suspicion. Case 2. Rocky Mountain spotted fever. (10208089)
1999
26
Israeli spotted fever rickettsia (Rickettsia conorii complex) associated with human disease in Portugal. (10603225)
1999
27
Rocky mountain spotted fever. (9868640)
1998
28
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. (9866756)
1998
29
Long-term sequelae of Rocky Mountain spotted fever. (7619986)
1995
30
Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. (8143383)
1994
31
Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 1. Clinical and epidemiological features. (1986207)
1991
32
Rocky Mountain spotted fever--United States, 1988. (2501644)
1989
33
Rocky Mountain spotted fever: mimicry of appendicitis or acute surgical abdomen? (3728395)
1986
34
Rocky Mountain spotted fever--United States, 1985. (3083229)
1986
35
Left ventricular dysfunction in Rocky Mountain spotted fever. (6627770)
1983
36
Neurogenic bladder in Rocky Mountain spotted fever. (6824406)
1983
37
Conjunctival hemorrhage and Rocky Mountain spotted fever. (7058380)
1982
38
Surveillance of Rocky Mountain spotted fever in the United States, 1978-1980. (7108278)
1982
39
Rocky mountain spotted fever in dogs and man. (7278854)
1981
40
The occurrence of eschars in Rocky Mountain spotted fever. (7240465)
1981
41
Rocky Mountain Spotted Fever. (7386797)
1980
42
Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. (96691)
1978
43
Rocky Mountain spotted fever in an infant: diagnosis in siblings. (685914)
1978
44
Early diagnosis of Rocky Mountain spotted fever. Use of primary monocyte culture technique. (814256)
1976
45
Rocky Mountain spotted fever: case presentation and general discussion. (1055501)
1975
46
Surveillance of Rocky Mountain spotted fever. (4740658)
1973
47
Anterior nongranulomatous uveitis associated with Rocky Mountain spotted fever. First report of a case. (5774294)
1969
48
HYPOFIBRINOGENEMIA IN ROCKY MOUNTAIN SPOTTED FEVER. REPORT OF A CASE. (14129057)
1964
49
Ecology on Rocky Mountain spotted Fever: a basic research project now in process in Virginia. (13831260)
1961
50
Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever. (18013649)
1933

Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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Search GEO for disease gene expression data for Spotted Fever.

Pathways for genes affiliated with Spotted Fever

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Compounds for genes affiliated with Spotted Fever

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Compounds related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1dipyrone43 1210.8G6PD, CHKB
2gssg439.8CHKB, G6PD
3gemfibrozil28 43 1211.8G6PD, CHKB
4guanidine hydrochloride439.7G6PD, CHKB
5malondialdehyde439.7G6PD, CHKB
6succinate439.7CHKB, G6PD
7uric acid43 2410.7CHKB, G6PD
8carnitine439.7G6PD, CHKB
9glucose 6-phosphate43 2410.7CHKB, G6PD
10alpha tocopherol439.7G6PD, CHKB
11mannitol43 1210.7CHKB, G6PD
12vitamin-e439.5G6PD, THBD
13ptca439.5CHKB, THBD
14glycerol43 24 1211.4CHKB, G6PD
15raloxifene43 49 28 1212.4CHKB, THBD
16fluvastatin43 49 28 1212.4CHKB, THBD
17nifedipine43 28 49 1212.4G6PD, THBD
18neopterin439.4THBD, CHKB
19theophylline43 28 24 1212.4CHKB, THBD
20pravastatin43 49 28 24 1213.4CHKB, THBD
21atorvastatin43 49 28 24 1213.4THBD, CHKB
22prednisolone43 28 1211.3THBD, CHKB
23cyclophosphamide43 49 1211.3G6PD, THBD
24pyruvate439.3CHKB, G6PD
25agarose439.3CHKB, THBD
26valine439.3G6PD, THBD
27simvastatin43 49 59 28 24 1214.3THBD, CHKB
28endotoxin439.2THBD, CHKB
29dmso439.2G6PD, THBD
30phosphatidylserine43 28 1211.1THBD, G6PD
31folate439.1THBD, AFF2, G6PD
32oxygen43 2410.1CCL13, CHKB, G6PD
33phosphatidylcholine439.0G6PD, THBD
34polyethylene glycol439.0CHKB, G6PD, THBD
35azathioprine43 2 49 1212.0CHKB, G6PD, THBD
36citrate439.0CHKB, G6PD, THBD
37thyroxine43 249.9CHKB, G6PD, THBD
38aspirin43 49 28 2411.9CHKB, G6PD, THBD
39ascorbic acid43 249.9THBD, G6PD, CHKB
40lactate438.9CHKB, G6PD, THBD
41creatinine438.9CHKB, G6PD, THBD
42aspartate438.9THBD, G6PD, CHKB
43h2o2438.9THBD, G6PD, CHKB
44steroid438.9THBD, CHKB, CCL13
45dexamethasone43 49 28 1211.9CCL13, CHKB, THBD
46estrogen438.8THBD, G6PD, CHKB
47atp43 289.8CHKB, G6PD, THBD
48nacl438.7CHKB, THBD
49glucose438.7CHKB, G6PD, THBD

GO Terms for genes affiliated with Spotted Fever

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Products for genes affiliated with Spotted Fever

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Sources for Spotted Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet