MCID: SPT005
MIFTS: 53

Spotted Fever malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Spotted Fever

About this section

Summaries for Spotted Fever

About this section
Disease Ontology:11 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary: Spotted Fever, also known as spotted fevers, is related to rickettsialpox and israeli tick typhus, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways are OX40 Pathway and EBV LMP1 signaling. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotypes are integument and respiratory system.

Wikipedia:71 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

About this section

Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1rickettsialpox32.6IFNG, IL10, TNF
2israeli tick typhus32.3CCL5, IFNG
3tularemia30.0IFNG, IL10, TNF
4hepatitis29.9IFNG, IL10, TNF
5rocky mountain spotted fever12.6
6japanese spotted fever12.4
7far eastern spotted fever12.3
8flinders island spotted fever12.3
9astrakhan spotted fever12.2
10rickettsia parkeri spotted fever12.1
11boutonneuse fever12.0
12african tick-bite fever11.7
13siberian tick typhus11.6
14queensland tick typhus11.5
15aneruptive fever11.4
16endemic typhus11.2
17colorado tick fever11.0
18indian tick typhus11.0
19stocco dos santos syndrome10.3IFNG, TNF
20asymptomatic neurosyphilis10.3IFNG, IL10
21pyridoxal 5'-phosphate-dependent epilepsy10.3IL10, TNF
22autosomal dominant deafness-onychodystrophy syndrome10.3IFNG, TNF
23tubular renal disease-cardiomyopathy syndrome10.2IL10, TNF
24distal trisomy 14q10.2IFNG, TNF
25lagophthalmos10.2IL10, TNF
26immunodeficiency due to a late component of complement deficiency10.2CXCL10, IFNG, IL10
27conidiobolomycosis10.2IL10, TNF
28periodontosis10.2CXCL10, IFNG, TNF
29rosacea10.2IFNG, IL10, SLC17A5
30urogenital adysplasia10.2THBD, VWF
31proximal symphalangism10.2CXCL10, IFNG, IL10
32tungiasis10.2IFNG, IL10
33severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.2IFNG, IL10, TNF
34degenerative disc disease10.2TNF, VWF
35plantar wart10.2IFNG, IL10, TNF
36parkinson disease 1110.2IFNG, IL10, TNF
37cyclosporiasis10.2IFNG, IL10, TNF
38neurotic disorder10.2IFNG, IL10, TNF
39senile reticular retinal degeneration10.2IFNG, IL10, TNF
40conduct disorder10.2IFNG, IL10, TNF
41pancreatic signet ring cell adenocarcinoma10.2IFNG, IL10, TNF
42vps11-related autosomal recessive hypomyelinating leukodystrophy10.2CCL5, TNF
43acute myeloid leukemia with recurrent genetic anomaly10.2IFNG, IL10, TNF
44microcephaly10.2IFNG, IL10, TNF
45plummer's disease10.1IFNG, IL10, TNF
46orbital osteomyelitis10.1IFNG, IL10, TNF
47disease of mental health10.1IFNG, IL10, TNF
48follicular adenoma10.1IFNG, IL10, TNF
49myiasis10.1IFNG, IL10, TNF
50heart conduction disease10.1IFNG, IL10, TNF

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Symptoms & Phenotypes for Spotted Fever

About this section

Symptoms:

 11 (show all 5)
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

MGI Mouse Phenotypes related to Spotted Fever according to GeneCards Suite gene sharing:

41 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8F2, IFNG, IL10, NOS2, THBD, TNF
2MP:00053888.7F2, IFNG, IL10, NOS2, THBD, TNF
3MP:00053818.4F2, IFNG, IL10, NOS2, THBD, TNF
4MP:00053917.9HTRA1, IFNG, IL10, NOS2, SLC17A5, TNF
5MP:00053847.8CXCL10, IFNG, IL10, NOS2, SLC17A5, THBD
6MP:00053787.7F2, HTRA1, IFNG, IL10, NOS2, SLC17A5
7MP:00053857.7CXCL10, F2, HTRA1, IFNG, IL10, NOS2
8MP:00053977.5CCL5, CXCL10, F2, IFNG, IL10, NOS2
9MP:00053877.4CCL5, CXCL10, F2, IFNG, IL10, NOS2
10MP:00053767.1CXCL10, F2, IFNG, IL10, NOS2, SLC17A5
11MP:00107687.1CXCL10, F2, IFNG, IL10, NOS2, SLC17A5
12MP:00036317.1CXCL10, F2, IFNG, IL10, NOS2, SLC17A5

Drugs & Therapeutics for Spotted Fever

About this section

Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins6394
2Antibodies6394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laboratory Diagnosis of of Rickettsial and Rickettsia-like DiseasesUnknown statusNCT01137175
2300 Antibody Diagnostic Test KitUnknown statusNCT01646411

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

About this section

Anatomical Context for Spotted Fever

About this section

MalaCards organs/tissues related to Spotted Fever:

36
Skin, Endothelial, Testes, T cells, Monocytes, Liver, Brain

FMA organs/tissues related to Spotted Fever:

17
Endothelial cell of artery or

Publications for Spotted Fever

About this section

Articles related to Spotted Fever:

(show top 50)    (show all 1028)
idTitleAuthorsYear
1
Rocky Mountain Spotted Fever. (27734445)
Fall
2
Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. (28500808)
2017
3
Rocky Mountain Spotted Fever. (28055518)
2017
4
High seroprevalence for indigenous spotted fever group rickettsiae in forestry workers from the federal state of Brandenburg, Eastern Germany. (27793612)
2017
5
The Detection of Spotted Fever Group Rickettsia DNA in Tick Samples From Pastoral Communities in Kenya. (28073909)
2017
6
Molecular detection of Rickettsia rhipicephali and other spotted fever group Rickettsia species in Amblyomma ticks infesting wild birds in the state of Minas Gerais, Brazil. (27745888)
2017
7
Association of the occurrence of Brazilian spotted fever and Atlantic rain forest fragmentation in the SALo Paulo metropolitan region, Brazil. (27880877)
2017
8
Sennetsu Neorickettsiosis, Spotted Fever Group, and Typhus Group Rickettsioses in Three Provinces in Thailand. (27139448)
2016
9
Fundus Examination: A Key to Spot the Spotted Fever! (26944429)
2016
10
Probability of occurrence of the Brazilian spotted fever in northeast of ParanA! state, Brazil. (27925056)
2016
11
Retrospective Study of Rocky Mountain Spotted Fever in Children. (27990680)
2016
12
Severe Israeli spotted fever with multiorgan failure in a child. (26905298)
2016
13
Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells. (27525249)
2016
14
Comparative value of blood and skin samples for diagnosis of spotted fever group rickettsial infection in model animals. (27282078)
2016
15
Kampinos National Park: a risk area for spotted fever group rickettsioses, central Poland? (27631765)
2016
16
Molecular detection of spotted fever group rickettsiae in ticks removed from humans in Turkey. (27131413)
2016
17
Hierarchical Bayesian Spatio-Temporal Analysis of Climatic and Socio-Economic Determinants of Rocky Mountain Spotted Fever. (26942604)
2016
18
Genetic identification of Rickettsia sp. strain Atlantic rainforest in an endemic area of a mild spotted fever in Rio Grande do Sul state, Southern Brazil. (27338183)
2016
19
Exposure of dogs to spotted fever group rickettsiae in urban sites associated with human rickettsioses in Costa Rica. (26995323)
2016
20
Emerging spotted fever group rickettsiae in ticks, northwestern China. (27554852)
2016
21
Analysis of Amblyomma sculptum haplotypes in an area endemic for Brazilian spotted fever. (27120044)
2016
22
Rickettsia sp. Strain Atlantic Rainforest Infection in a Patient from a Spotted Fever-Endemic Area in Southern Brazil. (27325804)
2016
23
Estimation of Rickettsia rickettsii copy number in the blood of patients with Rocky Mountain spotted fever suggests cyclic diurnal trends in bacteraemia. (26724989)
2016
24
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. (27508322)
2016
25
Molecular detection of spotted fever group rickettsiae in Amblyomma variegatum ticks from Benin. (27150592)
2016
26
Possible Case of Novel Spotted Fever Group Rickettsiosis in Traveler Returning to Japan from India. (27192498)
2016
27
Ecology of a tick-borne spotted fever in southern Brazil. (27392739)
2016
28
First report of spotted fever group Rickettsia in Cuba. (27378408)
2016
29
Spotted fever group rickettsiae in ticks of migratory birds in Romania. (27207258)
2016
30
Spotted Fever Group Rickettsioses and Murine Typhus in a Malaysian Teaching Hospital. (27402519)
2016
31
Novel spotted fever group rickettsiae in Haemaphysalis qinghaiensis ticks from Gansu, Northwest China. (26968160)
2016
32
Severe Fever with Thrombocytopenia Syndrome Complicated by Co-infection with Spotted Fever Group Rickettsiae, China. (27767921)
2016
33
Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. (27380385)
2016
34
Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. (27172113)
2016
35
A fatal case of Brazilian spotted fever in a non-endemic area in Brazil: the importance of having health professionals who understand the disease and its areas of transmission. (27812666)
2016
36
A Rare Case of Mediterranean Spotted Fever and Encephalitis. (28053795)
2016
37
Human Infection with Novel Spotted Fever Group Rickettsia Genotype, China, 2015. (27869588)
2016
38
Molecular detection and characterization of spotted fever group rickettsiae in ticks from Central Italy. (27365155)
2016
39
Diversity of spotted fever group Rickettsia infection in hard ticks from Suifenhe, Chinese-Russian border. (26976703)
2016
40
Distribution of Spotted Fever Group Rickettsiae in Hard Ticks (Ixodida: Ixodidae) from Panamanian Urban and Rural Environments (2007-2013). (27068930)
2016
41
State of the art of diagnosis of rickettsial diseases: the use of blood specimens for diagnosis of scrub typhus, spotted fever group rickettsiosis, and murine typhus. (27429138)
2016
42
Serologic evidence of the exposure of small mammals to spotted-fever Rickettsia and Rickettsia bellii in Minas Gerais, Brazil. (27031460)
2016
43
Detection of rickettsiae in fleas and ticks from areas of Costa Rica with history of spotted fever group rickettsioses. (27592065)
2016
44
Spotted Fever Group Rickettsia in the Pampa Biome, Brazil, 2015-2016. (27767913)
2016
45
An update on the epidemiological situation of spotted fever in Brazil. (27555867)
2016
46
Notes from the Field: Community-Based Prevention of Rocky Mountain Spotted Fever - Sonora, Mexico, 2016. (27880753)
2016
47
Scrub typhus and spotted fever among hospitalised children in South India: Clinical profile and serological epidemiology. (27514949)
2016
48
Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee. (27022147)
2016
49
Probable case of spotted fever group rickettsial infection in a new suspected endemic area, Colombia. (27614577)
2016
50
Rickettsia (Rickettsiales: Rickettsiaceae) Vector Biodiversity in High Altitude Atlantic Forest Fragments Within a Semiarid Climate: A New Endemic Area of Spotted-Fever in Brazil. (27480099)
2016

Variations for Spotted Fever

About this section

Expression for genes affiliated with Spotted Fever

About this section
Search GEO for disease gene expression data for Spotted Fever.

Pathways for genes affiliated with Spotted Fever

About this section

Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathwaysScoreTop Affiliating Genes
19.8IFNG, IL10
29.6CCL5, TNF
39.6F2, IFNG
49.5IFNG, THBD, TNF
5
Show member pathways
9.5IFNG, IL10, TNF
6
Show member pathways
9.5IFNG, IL10, TNF
79.5IFNG, IL10, TNF
89.5IFNG, IL10, TNF
99.5IFNG, IL10, TNF
109.5IFNG, IL10, TNF
119.5IFNG, IL10, TNF
12
Show member pathways
9.5IFNG, IL10, TNF
139.3CCL5, IFNG, TNF
14
Show member pathways
9.3IFNG, NOS2, TNF
159.3IFNG, NOS2, TNF
169.3IFNG, NOS2, TNF
17
Show member pathways
9.3IFNG, NOS2, TNF
189.3IL10, NOS2, TNF
199.3IL10, NOS2, TNF
209.3IL10, NOS2, TNF
219.2CXCL10, IFNG, NOS2
229.2CCL5, CXCL10, TNF
239.1IFNG, IL10, THBD, TNF
24
Show member pathways
9.1F2, THBD, VWF
25
Show member pathways
9.1F2, THBD, VWF
26
Show member pathways
9.0IFNG, IL10, NOS2, TNF
279.0IFNG, IL10, NOS2, TNF
289.0IFNG, IL10, NOS2, TNF
29
Show member pathways
8.9CCL5, CXCL10, IFNG, TNF
30
Show member pathways
8.9CCL5, CXCL10, IFNG, TNF
31
Show member pathways
8.9CXCL10, IFNG, NOS2, TNF
328.9CXCL10, IFNG, NOS2, TNF
338.9CCL5, CXCL10, IL10, TNF
348.9CCL5, CXCL10, IL10, TNF
35
Show member pathways
8.7CCL5, F2, IFNG, TNF
368.5CCL5, CXCL10, IFNG, IL10, TNF
37
Show member pathways
8.3F2, IFNG, IL10, NOS2, TNF
38
Show member pathways
8.0CCL5, CXCL10, IFNG, IL10, NOS2, TNF
39
Show member pathways
7.6CCL5, CXCL10, IFNG, IL10, NOS2, TNF
40
Show member pathways
7.4CCL5, CXCL10, F2, IFNG, IL10, NOS2

GO Terms for genes affiliated with Spotted Fever

About this section

Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.6CXCL10, F2, IFNG, TNF
2extracellular regionGO:00055767.9CCL5, CXCL10, F2, HTRA1, IFNG, IL10
3extracellular spaceGO:00056157.3CCL5, CXCL10, F2, HTRA1, IFNG, IL10

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1defense response to protozoanGO:004283210.5IFNG, IL10
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:004508010.5IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
5positive regulation of osteoclast differentiationGO:004567210.5IFNG, TNF
6positive regulation of protein complex assemblyGO:003133410.5IFNG, TNF
7endothelial cell apoptotic processGO:007257710.5IL10, TNF
8positive regulation of vitamin D biosynthetic processGO:006055710.5IFNG, TNF
9protein import into nucleus, translocationGO:000006010.5IFNG, TNF
10negative regulation of cytokine secretion involved in immune responseGO:000274010.5IL10, TNF
11positive regulation of MHC class II biosynthetic processGO:004534810.5IFNG, IL10
12negative regulation of interleukin-6 productionGO:003271510.5IL10, TNF
13negative regulation of mitotic cell cycleGO:004593010.5IL10, TNF
14positive regulation of heterotypic cell-cell adhesionGO:003411610.5IL10, TNF
15negative regulation of myoblast differentiationGO:004566210.4CXCL10, TNF
16positive regulation of vascular smooth muscle cell proliferationGO:190470710.4IL10, TNF
17receptor biosynthetic processGO:003280010.4IL10, TNF
18positive regulation of killing of cells of other organismGO:005171210.3IFNG, NOS2
19positive regulation of monocyte chemotaxisGO:009002610.2CCL5, CXCL10
20negative regulation of fibrinolysisGO:005191810.2F2, THBD
21negative regulation of platelet activationGO:001054410.2F2, THBD
22positive regulation of T cell migrationGO:200040610.2CCL5, CXCL10
23negative regulation of growth of symbiont in hostGO:004413010.2IFNG, IL10, TNF
24blood coagulation, intrinsic pathwayGO:000759710.1F2, VWF
25positive regulation of release of sequestered calcium ion into cytosolGO:005128110.1CXCL10, F2
26negative regulation of gene expressionGO:001062910.0IFNG, NOS2, TNF
27positive regulation of cell adhesionGO:004578510.0CCL5, IFNG, TNF
28positive regulation of protein phosphorylationGO:00019349.9F2, IFNG, TNF
29hemostasisGO:00075999.8F2, THBD, VWF
30defense response to bacteriumGO:00427429.7IFNG, IL10, NOS2, TNF
31inflammatory responseGO:00069549.6CCL5, CXCL10, IL10, TNF
32regulation of insulin secretionGO:00507969.4CCL5, IFNG, NOS2, TNF
33response to lipopolysaccharideGO:00324969.4CXCL10, IL10, NOS2, THBD
34cellular response to lipopolysaccharideGO:00712229.3CXCL10, IFNG, IL10, NOS2, TNF
35immune responseGO:00069559.3CCL5, CXCL10, IFNG, IL10, TNF
36response to virusGO:00096158.9CCL5, CXCL10, IFNG, TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.5CCL5, CXCL10, IFNG, IL10, TNF

Sources for Spotted Fever

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet