MCID: SPT005
MIFTS: 49

Spotted Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Spotted Fever

Summaries for Spotted Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted_by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary : Spotted Fever, also known as spotted fevers, is related to indian tick typhus and tularemia. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
id Related Disease Score Top Affiliating Genes
1 indian tick typhus 32.3 CCL5 IFNG
2 tularemia 30.5 IFNG IL10 TNF
3 chickenpox 29.7 THBD TNF VWF
4 rocky mountain spotted fever 12.6
5 japanese spotted fever 12.4
6 far eastern spotted fever 12.3
7 flinders island spotted fever 12.3
8 astrakhan spotted fever 12.2
9 rickettsia parkeri spotted fever 12.1
10 boutonneuse fever 12.0
11 queensland tick typhus 11.7
12 siberian tick typhus 11.6
13 african tick-bite fever 11.6
14 rickettsialpox 11.6
15 israeli tick typhus 11.4
16 aneruptive fever 11.4
17 endemic typhus 11.2
18 colorado tick fever 11.0
19 pure autonomic failure 10.8 IL10 TNF
20 sternal cleft 10.7 IFNG TNF
21 acute ackee fruit intoxication 10.7 IL10 TNF
22 chlamydia 10.7 HTRA1 IFNG
23 autoimmune polyglandular syndrome type 3 10.7 IFNG TNF
24 mosaic trisomy 1 10.7 IFNG TNF
25 primary systemic mycosis 10.7 IFNG TNF
26 basidiobolomycosis 10.7 IL10 TNF
27 lagophthalmos 10.7 IL10 TNF
28 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
29 eye accommodation disease 10.7 IFNG IL10
30 graft-versus-host disease, protection against 10.7 IFNG IL10
31 thelaziasis 10.7 IFNG IL10
32 dumping syndrome 10.7 IFNG IL10
33 idiopathic dilatation of the pulmonary artery 10.7 IL10 TNF
34 ethmoid sinus adenocarcinoma 10.7 IL10 TNF
35 liver leiomyoma 10.7 IL10 TNF
36 tarsal tunnel syndrome 10.7 IL10 TNF
37 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.6 IFNG IL10
38 amyotrophic lateral sclerosis type 10 10.6 IFNG TNF
39 unna-thost palmoplantar keratoderma 10.6 THBD VWF
40 lymphocytic colitis 10.6 IFNG TNF
41 gerstmann syndrome 10.6 IFNG IL10
42 pasteurellosis 10.6 IFNG TNF
43 centronuclear myopathy 5 10.6 IFNG IL10
44 strawberry gallbladder 10.6 IFNG IL10
45 chronic apical periodontitis 10.6 IL10 TNF
46 parametritis 10.6 IFNG TNF
47 smarca4-deficient sarcoma of thorax 10.6 CCL5 TNF
48 polyarteritis nodosa 10.5 IFNG TNF
49 sparse hair ptosis mental retardation 10.5 IFNG TNF
50 herpangina 10.5 IFNG IL10

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to Spotted Fever

Symptoms & Phenotypes for Spotted Fever

MGI Mouse Phenotypes related to Spotted Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 CXCL10 F2 HTRA1 IFNG IL10 THBD
2 hematopoietic system MP:0005397 10.13 CASP3 CCL5 CTLA4 CXCL10 F2 IFNG
3 immune system MP:0005387 10.07 CXCL10 F2 IFNG IL10 THBD TNF
4 digestive/alimentary MP:0005381 10.06 CASP3 CTLA4 F2 IFNG IL10 THBD
5 homeostasis/metabolism MP:0005376 10.06 CASP3 CTLA4 CXCL10 F2 IFNG IL10
6 mortality/aging MP:0010768 9.91 CASP3 CTLA4 CXCL10 F2 IFNG IL10
7 integument MP:0010771 9.87 CASP3 CTLA4 F2 IFNG IL10 THBD
8 nervous system MP:0003631 9.76 CASP3 CXCL10 F2 IFNG IL10 THBD
9 respiratory system MP:0005388 9.5 CASP3 CTLA4 F2 IFNG IL10 THBD
10 skeleton MP:0005390 9.17 CASP3 CTLA4 F2 HTRA1 IFNG IL10

Drugs & Therapeutics for Spotted Fever

Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies
3 Immunoglobulin A
4 Immunoglobulin M

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
2 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
3 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

Anatomical Context for Spotted Fever

MalaCards organs/tissues related to Spotted Fever:

39
Skin, Endothelial, Testes, Liver, Monocytes, T Cells, Brain

Publications for Spotted Fever

Articles related to Spotted Fever:

(show top 50) (show all 1049)
id Title Authors Year
1
Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. ( 28500808 )
2017
2
Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. ( 28775717 )
2017
3
Spotted fever rickettsiae and tuberculous meningitis dual infection presenting as acute encephalitis syndrome: A fatal case report. ( 28748844 )
2017
4
Seroprevalence of spotted fever group (SFG) rickettsiae infection in domestic ruminants in Khartoum State, Sudan. ( 28713577 )
2017
5
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. ( 28806774 )
2017
6
Rocky Mountain Spotted Fever. ( 28055518 )
2017
7
Child Neurology: Rocky Mountain spotted fever encephalitis. ( 28289173 )
2017
8
Evidence of infection with Leptospira interrogans and spotted fever group rickettsiae among rodents in an urban area of Osaka City, Japan. ( 28529271 )
2017
9
The Detection of Spotted Fever Group Rickettsia DNA in Tick Samples From Pastoral Communities in Kenya. ( 28073909 )
2017
10
Rickettsia australis and Queensland Tick Typhus: A Rickettsial Spotted Fever Group Infection in Australia. ( 28719297 )
2017
11
Tick, Rickettsia Rickettsiae (Rocky Mountain Spotted Fever) ( 28613631 )
2017
12
Serological and molecular detection of spotted fever group Rickettsia in a group of pet dogs from Luanda, Angola. ( 28569177 )
2017
13
Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma, Ehrlichia, and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. ( 28598270 )
2017
14
Spotted Fever Group Rickettsioses (SFGR): weather and incidence in Illinois. ( 28743316 )
2017
15
Rocky Mountain Spotted Fever and Pregnancy: Four Cases from Sonora, Mexico. ( 28722584 )
2017
16
Evaluation of a Spotted Fever Group Rickettsia Public Health Surveillance System in Tennessee. ( 28722610 )
2017
17
Spotted fever rickettsiae in wild-living rodents from south-western Poland. ( 28874204 )
2017
18
Fatal Rocky Mountain Spotted Fever along the United States-Mexico Border, 2013-2016. ( 28930006 )
2017
19
Rickettsia gravesii sp. nov.: a novel spotted fever group rickettsia in Western Australian Amblyomma triguttatum triguttatum ticks. ( 28857025 )
2017
20
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. ( 28764157 )
2017
21
Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia. ( 28722568 )
2017
22
Association of the occurrence of Brazilian spotted fever and Atlantic rain forest fragmentation in the SALo Paulo metropolitan region, Brazil. ( 27880877 )
2017
23
Molecular detection of Rickettsia rhipicephali and other spotted fever group Rickettsia species in Amblyomma ticks infesting wild birds in the state of Minas Gerais, Brazil. ( 27745888 )
2017
24
High seroprevalence for indigenous spotted fever group rickettsiae in forestry workers from the federal state of Brandenburg, Eastern Germany. ( 27793612 )
2017
25
Spotted Fever: Epidemiology and Vector-Rickettsia-Host Relationship in Rio de Janeiro State. ( 28424664 )
2017
26
Geographical Distribution of Japanese Spotted Fever and Tsutsugamushi Disease in Japan - Possible Effect of Environmental Temperature. ( 28250253 )
2017
27
Development of an electrochemical immunosensor for the diagnostic testing of spotted fever using synthetic peptides. ( 28886455 )
2017
28
Rocky Mountain spotted fever in Mexico: past, present, and future. ( 28365226 )
2017
29
Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. ( 27172113 )
2016
30
Rickettsia sp. Strain Atlantic Rainforest Infection in a Patient from a Spotted Fever-Endemic Area in Southern Brazil. ( 27325804 )
2016
31
Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee. ( 27022147 )
2016
32
Rickettsia amblyommatis sp. nov.,a spotted fever group rickettsia associated with multiple species of Amblyomma ticks in North and South America. ( 27638476 )
2016
33
Distribution of Spotted Fever Group Rickettsiae in Hard Ticks (Ixodida: Ixodidae) from Panamanian Urban and Rural Environments (2007-2013). ( 27068930 )
2016
34
Estimation of Rickettsia rickettsii copy number in the blood of patients with Rocky Mountain spotted fever suggests cyclic diurnal trends in bacteraemia. ( 26724989 )
2016
35
Severe Israeli spotted fever with multiorgan failure in a child. ( 26905298 )
2016
36
Notes from the Field: Community-Based Prevention of Rocky Mountain Spotted Fever - Sonora, Mexico, 2016. ( 27880753 )
2016
37
Detection of rickettsiae in fleas and ticks from areas of Costa Rica with history of spotted fever group rickettsioses. ( 27592065 )
2016
38
Probable case of spotted fever group rickettsial infection in a new suspected endemic area, Colombia. ( 27614577 )
2016
39
Exposure of dogs to spotted fever group rickettsiae in urban sites associated with human rickettsioses in Costa Rica. ( 26995323 )
2016
40
Fundus Examination: A Key to Spot the Spotted Fever! ( 26944429 )
2016
41
Molecular detection of spotted fever group rickettsiae in Amblyomma variegatum ticks from Benin. ( 27150592 )
2016
42
Spotted Fever Group Rickettsia in the Pampa Biome, Brazil, 2015-2016. ( 27767913 )
2016
43
An update on the epidemiological situation of spotted fever in Brazil. ( 27555867 )
2016
44
Rickettsia (Rickettsiales: Rickettsiaceae) Vector Biodiversity in High Altitude Atlantic Forest Fragments Within a Semiarid Climate: A New Endemic Area of Spotted-Fever in Brazil. ( 27480099 )
2016
45
Molecular detection of spotted fever group rickettsiae in ticks removed from humans in Turkey. ( 27131413 )
2016
46
Molecular detection and characterization of spotted fever group rickettsiae in ticks from Central Italy. ( 27365155 )
2016
47
First report of spotted fever group Rickettsia in Cuba. ( 27378408 )
2016
48
Sennetsu Neorickettsiosis, Spotted Fever Group, and Typhus Group Rickettsioses in Three Provinces in Thailand. ( 27139448 )
2016
49
Scrub typhus and spotted fever among hospitalised children in South India: Clinical profile and serological epidemiology. ( 27514949 )
2016
50
Genetic identification of Rickettsia sp. strain Atlantic rainforest in an endemic area of a mild spotted fever in Rio Grande do Sul state, Southern Brazil. ( 27338183 )
2016

Variations for Spotted Fever

Expression for Spotted Fever

Search GEO for disease gene expression data for Spotted Fever.

Pathways for Spotted Fever

Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 41)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 CASP3 CCL5 CTLA4 CXCL10 IFNG IL10
2
Show member pathways
13.5 CASP3 CCL5 CXCL10 F2 IFNG IL10
3
Show member pathways
13.13 CASP3 CCL5 CXCL10 IFNG IL10 TNF
4
Show member pathways
12.72 CASP3 CTLA4 IFNG IL10 TNF
5
Show member pathways
12.71 CCL5 CXCL10 IFNG IL10 TNF
6
Show member pathways
12.67 CASP3 CCL5 CXCL10 IFNG TNF
7
Show member pathways
12.6 CCL5 CXCL10 IFNG TNF
8
Show member pathways
12.47 F2 IFNG IL10 TNF
9
Show member pathways
12.32 CTLA4 IFNG IL10 TNF
10
Show member pathways
12.22 CASP3 CXCL10 IFNG TNF
11
Show member pathways
12.13 CASP3 IFNG IL10 TNF
12 12.08 CASP3 IFNG IL10 TNF
13
Show member pathways
12.07 CXCL10 IFNG TNF
14 12.06 CASP3 IFNG TNF
15 12.05 CASP3 IL10 TNF
16
Show member pathways
12.05 F2 THBD VWF
17
Show member pathways
12.03 IFNG IL10 TNF
18 11.97 F2 THBD VWF
19 11.97 IFNG THBD TNF
20 11.89 IFNG IL10 TNF
21
Show member pathways
11.84 IFNG IL10 TNF
22 11.81 CASP3 CXCL10 IFNG TNF
23 11.8 CASP3 THBD TNF
24 11.74 CASP3 CCL5 CXCL10 TNF
25 11.7 IFNG IL10 TNF
26 11.67 CASP3 IL10 TNF
27 11.65 CASP3 IFNG IL10 TNF
28 11.62 CTLA4 IL10 TNF
29 11.6 CCL5 CTLA4 CXCL10 IFNG IL10 TNF
30 11.58 CCL5 CTLA4 IFNG TNF
31
Show member pathways
11.44 CASP3 CTLA4 IFNG TNF
32 11.43 IFNG IL10 TNF
33 11.34 IFNG IL10 THBD TNF
34
Show member pathways
11.29 IFNG IL10 TNF
35 11.21 IFNG IL10 TNF
36 11.11 IFNG IL10 TNF
37 11.1 IFNG IL10
38 11.08 F2 IFNG
39 11.08 CCL5 CXCL10 IL10 TNF
40 11.06 CCL5 TNF
41 10.95 CCL5 CXCL10 IL10 TNF

GO Terms for Spotted Fever

Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CCL5 CXCL10 F2 HTRA1 IFNG IL10
2 extracellular space GO:0005615 9.56 CCL5 CXCL10 F2 HTRA1 IFNG IL10
3 external side of plasma membrane GO:0009897 9.02 CTLA4 CXCL10 F2 IFNG TNF

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 40)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CCL5 CXCL10 IL10 TNF
2 positive regulation of apoptotic process GO:0043065 9.92 CASP3 CTLA4 IFNG TNF
3 positive regulation of protein phosphorylation GO:0001934 9.83 F2 IFNG TNF
4 response to organic substance GO:0010033 9.78 CASP3 IL10 TNF
5 response to lipopolysaccharide GO:0032496 9.76 CASP3 CXCL10 IL10 THBD
6 cellular response to organic cyclic compound GO:0071407 9.73 CASP3 CCL5 TNF
7 response to wounding GO:0009611 9.72 CASP3 F2 VWF
8 response to glucocorticoid GO:0051384 9.71 CASP3 IL10 TNF
9 regulation of insulin secretion GO:0050796 9.7 CCL5 IFNG TNF
10 protein import into nucleus, translocation GO:0000060 9.68 IFNG TNF
11 response to tumor necrosis factor GO:0034612 9.68 CASP3 CCL5
12 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.68 CXCL10 F2
13 negative regulation of interleukin-6 production GO:0032715 9.67 IL10 TNF
14 positive regulation of protein complex assembly GO:0031334 9.67 IFNG TNF
15 response to X-ray GO:0010165 9.67 CASP3 THBD
16 hemostasis GO:0007599 9.67 F2 THBD VWF
17 negative regulation of myoblast differentiation GO:0045662 9.66 CXCL10 TNF
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.66 IL10 TNF
19 defense response to protozoan GO:0042832 9.65 IFNG IL10
20 positive regulation of osteoclast differentiation GO:0045672 9.65 IFNG TNF
21 positive regulation of cell adhesion GO:0045785 9.65 CCL5 IFNG TNF
22 positive regulation of monocyte chemotaxis GO:0090026 9.64 CCL5 CXCL10
23 blood coagulation, intrinsic pathway GO:0007597 9.64 F2 VWF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IFNG TNF
25 positive regulation of T cell migration GO:2000406 9.62 CCL5 CXCL10
26 cellular response to lipopolysaccharide GO:0071222 9.62 CXCL10 IFNG IL10 TNF
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
28 positive regulation of chemokine biosynthetic process GO:0045080 9.6 IFNG TNF
29 negative regulation of fibrinolysis GO:0051918 9.59 F2 THBD
30 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
31 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IFNG IL10
33 response to virus GO:0009615 9.56 CCL5 CXCL10 IFNG TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 IL10 TNF
35 receptor biosynthetic process GO:0032800 9.43 IL10 TNF
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
37 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
38 negative regulation of B cell proliferation GO:0030889 9.33 CASP3 CTLA4 IL10
39 negative regulation of growth of symbiont in host GO:0044130 9.13 IFNG IL10 TNF
40 immune response GO:0006955 9.1 CCL5 CTLA4 CXCL10 IFNG IL10 TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 CASP3 TNF VWF
2 cytokine activity GO:0005125 9.02 CCL5 CXCL10 IFNG IL10 TNF

Sources for Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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