MCID: SPT005
MIFTS: 55

Spotted Fever malady

Infectious diseases category

Summaries for Spotted Fever

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards: Spotted Fever, also known as spotted fevers, is related to typhus and japanese spotted fever, and has symptoms including maculopapular or petechial rash, muscle aches and fatigue. An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds rantes and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotype nervous system.

Wikipedia:63 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Aliases & Classifications for Spotted Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Spotted Fever

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Clinical Features for Spotted Fever

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8Disease Ontology
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Symptoms:

8
  • maculopapular or petechial rash
  • muscle aches
  • fatigue
  • headache
  • fever

Drugs & Therapeutics for Spotted Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spotted Fever

Drug clinical trials:

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Search CenterWatch for Spotted Fever

Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Spotted Fever:

32
Skin, Endothelial, Testes, T cells, Monocytes, Brain, Liver, Kidney, Lymph node, Skeletal muscle

FMA organs/tissues related to Spotted Fever:

14
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spotted Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.9SLC17A5, THBD, CXCL10, CHKB, AFF2, YAP1

Publications for Spotted Fever

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50PubMed
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Articles related to Spotted Fever:

(show top 50)    (show all 911)
idTitleAuthorsYear
1
Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais State, Brazil. (23509125)
2013
2
Knowledge, attitudes, and practices regarding Rocky Mountain spotted fever among healthcare providers, Tennessee, 2009. (23243110)
2013
3
Molecular detection and analysis of spotted fever group Rickettsia in patients with fever and rash at a tertiary care centre in Tamil Nadu, India. (22595273)
2012
4
Spotted fever group Rickettsiae in ticks in Cyprus. (21833539)
2012
5
A fatal urban case of rocky mountain spotted fever presenting an eschar in San Jose, Costa Rica. (22855769)
2012
6
Epidemiological characteristics of Brazilian spotted fever in Minas Gerais State, Brazil, 2000-2008. (22031201)
2011
7
A Kunitz protease inhibitor from Dermacentor variabilis, a vector for spotted fever group rickettsiae, limits Rickettsia montanensis invasion. (20956566)
2011
8
Dissemination of spotted fever rickettsia agents in Europe by migrating birds. (20052286)
2010
9
Serological prevalence study of exposure of cats and dogs in Launceston, Tasmania, Australia to spotted fever group rickettsiae. (20148824)
2010
10
Rickettsia in synanthropic and domestic animals and their hosts from two areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais, Brazil. (21118939)
2010
11
Spotted fever in a child in Mumbai, India. (19959860)
2009
12
Spatial clustering by disease severity among reported Rocky Mountain spotted fever cases in the United States, 2001-2005. (19141843)
2009
13
Markers of exposure to spotted fever rickettsiae in patients with chronic illness, including fatigue, in two Australian populations. (18287113)
2008
14
An increase in human cases of spotted fever rickettsiosis in Yucatan, Mexico, involving children. (19052302)
2008
15
Rickettsial spotted fever in capoeirALo village, Itabira, Minas Gerais, Brazil. (18949349)
2008
16
Questions on Mediterranean spotted fever a century after its discovery. (18760001)
2008
17
Rocky Mountain spotted fever. (16643138)
2006
18
Borrelia lusitaniae and spotted fever group rickettsiae in Ixodes ricinus (Acari: Ixodidae) in Tuscany, central Italy. (16619594)
2006
19
Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. (14999622)
2004
20
Imported spotted fever rickettsioses in United States travelers returning from Africa: a summary of cases confirmed by laboratory testing at the Centers for Disease Control and Prevention, 1999-2002. (14971705)
2004
21
Molecular evidence for novel tick-associated spotted fever group rickettsiae from Thailand. (12693853)
2003
22
Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. (14507644)
2003
23
Antibodies reactive with Ehrlichia canis, Ehrlichia phagocytophila genogroup antigens and the spotted fever group rickettsial antigens, in free-ranging jackals (Canis aureus syriacus) from Israel. (10321583)
1999
24
A spotted fever and melaena: acute HIV seroconversion. (9506384)
1998
25
Plasma levels of tumor necrosis factor-alpha and interferon-gamma in Sicilian children with Mediterranean spotted fever. (9266285)
1997
26
Rocky Mountain spotted fever versus Lyme disease. (7839177)
1995
27
Rocky Mountain spotted fever in the elderly. (1991953)
1991
28
Rapid immunoperoxidase demonstration of Rickettsia rickettsii in fixed cutaneous specimens from patients with Rocky Mountain spotted fever. (2106778)
1990
29
The epidemiology of Rocky Mountain spotted fever in Arkansas, Oklahoma, and Texas, 1981 through 1985. (3369426)
1988
30
Rocky Mountain spotted fever--United States, 1987. (3131657)
1988
31
Potential for free radical-induced lipid peroxidation as a cause of endothelial cell injury in Rocky Mountain spotted fever. (3141280)
1988
32
Acquired coagulation inhibitor in association with Rocky Mountain spotted fever. With a review of other acquired coagulation inhibitors. (3621770)
1987
33
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
34
Rocky Mountain spotted fever in Georgia, 1961-75: analysis of social and environmental factors affecting occurrence. (3090609)
1986
35
Spotted fever group rickettsiae in immature and adult ticks (Acari: Ixodidae) from a focus of Rocky Mountain spotted fever in Connecticut. (3938341)
1985
36
Rocky Mountain Spotted Fever--a reminder. (6842117)
1983
37
Rickettsial diseases and Rocky Mountain spotted fever--Part I. (7016456)
1981
38
Laboratory diagnosis of Rocky Mountain spotted fever. (6777873)
1980
39
Kidney lesions in Rocky Mountain spotted fever: a light-, immunofluorescence-, and electron-microscopic study. (525676)
1979
40
Discrepancies in Weil-Felix and microimmunofluorescence test results for Rocky Mountain spotted fever. (107194)
1979
41
Mucocutaneous lymph node syndrome. A case masquerading as Rocky Mountain spotted fever. (576923)
1977
42
Antibody response to Rocky Mountain spotted fever. (819455)
1976
43
Rocky Mountain spotted fever: case presentation and general discussion. (1055501)
1975
44
Rocky Mountain spotted fever in Kentucky. (1168683)
1975
45
Rocky Mountain spotted fever. (4740662)
1973
46
Epidemiology of Rocky Mountain spotted fever and murine typhus. (5495622)
1970
47
Rocky Mountain spotted fever. A vascular disease. (5424499)
1970
48
The ecology of ticks transmitting Rocky Mountain spotted fever in a study area in Virginia. (5979107)
1966
49
Rocky Mountain spotted fever: clinical and laboratory observations of monkeys after respiratory exposure. (4956209)
1966
50
Rocky Mountain Spotted Fever and Endemic Typhus Fever: As Observed in California. (18743103)
1934

Genetic Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spotted Fever

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Pathways for genes affiliated with Spotted Fever

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Compounds for genes affiliated with Spotted Fever

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Spotted Fever according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1rantes4410.5IDO1
2alpha-hydroxybutyrate4410.5SLC17A5, CHKB
3dipyrone44 1111.5CHKB, G6PD
4thiobarbituric acid4410.4SLC17A5, G6PD
5malondialdehyde4410.3G6PD, CHKB, SLC17A5
6succinylcholine44 28 1112.3SLC17A5, CHKB
7ribavirin44 49 1112.2G6PD, CXCL10, SLC17A5
8polyethylene glycol4410.2G6PD, CHKB, THBD, SLC17A5
9uric acid44 2411.2G6PD, CHKB, SLC17A5
10dexamethasone44 49 28 1113.2CCL13, IDO1, CXCL9
11folate4410.2SLC17A5, THBD, AFF2, G6PD
12thyroxine44 2411.2SLC17A5, THBD, CHKB, G6PD
13carnitine4410.2SLC17A5, CHKB, G6PD
14tarc4410.2CCL13, CXCL10, CXCL9
15triiodothyronine4410.2SLC17A5, KHDRBS3, CHKB
16vitamin-e4410.1SLC17A5, THBD, G6PD, IDO1
17zinc protoporphyrin4410.1G6PD, SLC17A5
18ccl444 2811.1CXCL10, CXCL9, SLC17A5
19ascorbic acid44 2411.1G6PD, CHKB, THBD, SLC17A5
20azathioprine44 49 2 1113.1G6PD, CHKB, THBD
21beta-hydroxybutyrate4410.0CHKB, SLC17A5
22quinine44 28 2 1113.0SLC17A5, CXCL9, G6PD, IDO1
23prednisolone44 28 1112.0SLC17A5, THBD, CHKB
24neopterin449.9SLC17A5, THBD, CXCL10, CHKB, IDO1
25endotoxin449.9CHKB, CXCL10, CXCL9, THBD, SLC17A5
26h2o2449.9HTRA1, G6PD, CHKB, THBD, SLC17A5
27histamine44 28 2411.7CCL13, PPP1R14A, CXCL10, CXCL9, THBD
28creatinine449.7G6PD, CHKB, CXCL10, CXCL9, THBD, SLC17A5
29atorvastatin44 49 28 11 2413.7SLC17A5, THBD, CHKB
30alanine449.7SLC17A5, THBD, KHDRBS3, CXCL10, CHKB, HTRA1
31nitric oxide44 11 2411.6SLC17A5, THBD, CXCL9, CXCL10, CHKB, IDO1
32glucose449.5IRS4, G6PD, CHKB, CXCL10, THBD, SLC17A5
33atp44 2810.5G6PD, CHKB, CXCL10, CXCL9, THBD, SLC17A5
34tyrosine449.1IDO1, IRS4, YAP1, CXCL10, CXCL9, KHDRBS3

GO Terms for genes affiliated with Spotted Fever

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16Gene Ontology
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Biological processes related to Spotted Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:0069359.8CXCL9, CXCL10, CCL13

Molecular functions related to Spotted Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL9, CXCL10, CCL13

Products for genes affiliated with Spotted Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spotted Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet