MCID: SPT005
MIFTS: 45

Spotted Fever malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Spotted Fever

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Summaries for Spotted Fever

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Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary: Spotted Fever, also known as spotted fevers, is related to mediterranean spotted fever and vascular disease, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds dipyrone and gssg have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotype nervous system.

Wikipedia:64 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

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Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Symptoms for Spotted Fever

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Symptoms:

 8
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

Drugs & Therapeutics for Spotted Fever

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Drug clinical trials:

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Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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MalaCards organs/tissues related to Spotted Fever:

31
Skin, Endothelial, Testes, Brain, Liver, T cells, Lymph node, Skeletal muscle, Kidney, Monocytes

FMA organs/tissues related to Spotted Fever:

14
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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MGI Mouse Phenotypes related to Spotted Fever:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1CHKB, G6PD, AFF2, THBD

Publications for Spotted Fever

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Articles related to Spotted Fever:

(show top 50)    (show all 940)
idTitleAuthorsYear
1
Assessment of prevalence and distribution of spotted fever group rickettsiae in Manitoba, Canada, in the American dog tick, Dermacentor variabilis (Acari: Ixodidae). (25700040)
2015
2
Mediterranean Spotted Fever in Children in the Pazardjik Region, South Bulgaria. (24263221)
2013
3
A neonatal case of Japanese spotted fever. (23743544)
2013
4
Mediterranean spotted fever with involvement of the gastrointestinal tract. (23880573)
2013
5
Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais State, Brazil. (23509125)
2013
6
Rickettsioses in the central hills of Sri Lanka: serological evidence of increasing burden of spotted fever group. (23871280)
2013
7
Rapid, simple, and sensitive detection of the ompB gene of spotted fever group rickettsiae by loop-mediated isothermal amplification. (23057497)
2012
8
Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever. (21797105)
2011
9
Coronary involvement in Mediterranean spotted fever. (22143818)
2011
10
Rocky Mountain spotted fever in Panama: a cluster description. (21997944)
2011
11
Dissemination of spotted fever rickettsia agents in Europe by migrating birds. (20052286)
2010
12
Serosurvey of antibodies against spotted fever group Rickettsia spp. in horse farms in Northern ParanA!, Brazil. (21184706)
2010
13
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
14
Rickettsia rickettsii, Rickettsia felis and Rickettsia sp. TwKM03 infecting Rhipicephalus sanguineus and Ctenocephalides felis collected from dogs in a Brazilian spotted fever focus in the State of Rio De Janeiro/Brazil. (19298400)
2009
15
A case of spotted fever group rickettsiosis imported into the United Kingdom and treated with ciprofloxacin: a case report. (18387179)
2008
16
Rocky Mountain spotted fever in Argentina. (18385370)
2008
17
Rocky Mountain spotted fever, Colombia. (18214179)
2007
18
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (17674321)
2007
19
Experimental transmission of Rocky Mountain spotted fever by means of the tick. 1906. (16550763)
2006
20
Human spotted fever rickettsial infections. (15829206)
2005
21
Rocky Mountain Spotted Fever, another important cause of fever and rash. (15498625)
2004
22
Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever. (12353892)
2002
23
Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. (12200314)
2002
24
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
25
Index of suspicion. Case 2. Rocky Mountain spotted fever. (10208089)
1999
26
Israeli spotted fever rickettsia (Rickettsia conorii complex) associated with human disease in Portugal. (10603225)
1999
27
Rocky mountain spotted fever. (9868640)
1998
28
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. (9866756)
1998
29
Long-term sequelae of Rocky Mountain spotted fever. (7619986)
1995
30
Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. (8143383)
1994
31
Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 1. Clinical and epidemiological features. (1986207)
1991
32
Rocky Mountain spotted fever--United States, 1988. (2501644)
1989
33
Rocky Mountain spotted fever: mimicry of appendicitis or acute surgical abdomen? (3728395)
1986
34
Rocky Mountain spotted fever--United States, 1985. (3083229)
1986
35
Left ventricular dysfunction in Rocky Mountain spotted fever. (6627770)
1983
36
Neurogenic bladder in Rocky Mountain spotted fever. (6824406)
1983
37
Conjunctival hemorrhage and Rocky Mountain spotted fever. (7058380)
1982
38
Surveillance of Rocky Mountain spotted fever in the United States, 1978-1980. (7108278)
1982
39
Rocky mountain spotted fever in dogs and man. (7278854)
1981
40
The occurrence of eschars in Rocky Mountain spotted fever. (7240465)
1981
41
Rocky Mountain Spotted Fever. (7386797)
1980
42
Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. (96691)
1978
43
Rocky Mountain spotted fever in an infant: diagnosis in siblings. (685914)
1978
44
Early diagnosis of Rocky Mountain spotted fever. Use of primary monocyte culture technique. (814256)
1976
45
Rocky Mountain spotted fever: case presentation and general discussion. (1055501)
1975
46
Surveillance of Rocky Mountain spotted fever. (4740658)
1973
47
Anterior nongranulomatous uveitis associated with Rocky Mountain spotted fever. First report of a case. (5774294)
1969
48
HYPOFIBRINOGENEMIA IN ROCKY MOUNTAIN SPOTTED FEVER. REPORT OF A CASE. (14129057)
1964
49
Ecology on Rocky Mountain spotted Fever: a basic research project now in process in Virginia. (13831260)
1961
50
Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever. (18013649)
1933

Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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Search GEO for disease gene expression data for Spotted Fever.

Pathways for genes affiliated with Spotted Fever

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Compounds for genes affiliated with Spotted Fever

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Compounds related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1dipyrone44 1110.8G6PD, CHKB
2gssg449.8CHKB, G6PD
3gemfibrozil28 44 1111.8CHKB, G6PD
4guanidine hydrochloride449.7G6PD, CHKB
5malondialdehyde449.7G6PD, CHKB
6succinate449.7G6PD, CHKB
7uric acid44 2410.7CHKB, G6PD
8carnitine449.7CHKB, G6PD
9glucose 6-phosphate44 2410.7CHKB, G6PD
10alpha tocopherol449.7G6PD, CHKB
11mannitol44 1110.7G6PD, CHKB
12vitamin-e449.5G6PD, THBD
13ptca449.5CHKB, THBD
14glycerol44 24 1111.4CHKB, G6PD
15raloxifene44 50 28 1112.4CHKB, THBD
16fluvastatin44 50 28 1112.4THBD, CHKB
17nifedipine44 28 50 1112.4G6PD, THBD
18neopterin449.4THBD, CHKB
19theophylline44 28 24 1112.4THBD, CHKB
20pravastatin44 50 28 24 1113.4THBD, CHKB
21atorvastatin44 50 28 24 1113.4CHKB, THBD
22prednisolone44 28 1111.3THBD, CHKB
23cyclophosphamide44 50 1111.3G6PD, THBD
24pyruvate449.3G6PD, CHKB
25agarose449.3CHKB, THBD
26valine449.3THBD, G6PD
27simvastatin44 50 60 28 24 1114.3THBD, CHKB
28endotoxin449.2THBD, CHKB
29dmso449.2G6PD, THBD
30phosphatidylserine44 28 1111.1G6PD, THBD
31folate449.1THBD, G6PD, AFF2
32oxygen44 2410.1G6PD, CCL13, CHKB
33phosphatidylcholine449.0THBD, G6PD
34polyethylene glycol449.0G6PD, THBD, CHKB
35azathioprine44 1 50 1112.0CHKB, G6PD, THBD
36citrate449.0G6PD, CHKB, THBD
37thyroxine44 249.9CHKB, G6PD, THBD
38aspirin44 50 28 2411.9THBD, G6PD, CHKB
39ascorbic acid44 249.9CHKB, G6PD, THBD
40lactate448.9THBD, CHKB, G6PD
41creatinine448.9G6PD, THBD, CHKB
42aspartate448.9CHKB, G6PD, THBD
43h2o2448.9CHKB, G6PD, THBD
44steroid448.9CHKB, CCL13, THBD
45dexamethasone44 50 28 1111.9CHKB, CCL13, THBD
46estrogen448.8G6PD, CHKB, THBD
47atp44 289.8G6PD, CHKB, THBD
48nacl448.7CHKB, THBD
49glucose448.7THBD, CHKB, G6PD

GO Terms for genes affiliated with Spotted Fever

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Sources for Spotted Fever

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet