MCID: SPT005
MIFTS: 52

Spotted Fever malady

Rare diseases, Infectious diseases categories
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Summaries for Spotted Fever

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards: Spotted Fever, also known as spotted fevers, is related to mediterranean spotted fever and vascular disease, and has symptoms including maculopapular or petechial rash, muscle aches and fatigue. An important gene associated with Spotted Fever is AFF2 (AF4/FMR2 family, member 2). The compounds dipyrone and gssg have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related mouse phenotype nervous system.

Wikipedia:65 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Aliases & Classifications for Spotted Fever

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Spotted Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to spotted fever

Symptoms for Spotted Fever

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8Disease Ontology
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Symptoms:

8
  • maculopapular or petechial rash
  • muscle aches
  • fatigue
  • headache
  • fever

Drugs & Therapeutics for Spotted Fever

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Spotted Fever

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Anatomical Context for Spotted Fever

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Spotted Fever:

33
Skin, Endothelial, Testes, T cells, Monocytes, Liver, Brain, Kidney, Skeletal muscle, Lymph node

FMA organs/tissues related to Spotted Fever:

14
Endothelial cell of artery or

Animal Models for Spotted Fever or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Spotted Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1CHKB, G6PD, AFF2, THBD

Publications for Spotted Fever

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52PubMed
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Articles related to Spotted Fever:

(show top 50)    (show all 894)
idTitleAuthorsYear
1
Mediterranean Spotted Fever in Children in the Pazardjik Region, South Bulgaria. (24263221)
2013
2
A neonatal case of Japanese spotted fever. (23743544)
2013
3
Mediterranean spotted fever with involvement of the gastrointestinal tract. (23880573)
2013
4
Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the eastern region of Minas Gerais State, Brazil. (23509125)
2013
5
Rickettsioses in the central hills of Sri Lanka: serological evidence of increasing burden of spotted fever group. (23871280)
2013
6
Rapid, simple, and sensitive detection of the ompB gene of spotted fever group rickettsiae by loop-mediated isothermal amplification. (23057497)
2012
7
Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever. (21797105)
2011
8
Rocky Mountain spotted fever in Panama: a cluster description. (21997944)
2011
9
Dissemination of spotted fever rickettsia agents in Europe by migrating birds. (20052286)
2010
10
Serosurvey of antibodies against spotted fever group Rickettsia spp. in horse farms in Northern ParanA!, Brazil. (21184706)
2010
11
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
12
Rickettsia rickettsii, Rickettsia felis and Rickettsia sp. TwKM03 infecting Rhipicephalus sanguineus and Ctenocephalides felis collected from dogs in a Brazilian spotted fever focus in the State of Rio De Janeiro/Brazil. (19298400)
2009
13
A case of spotted fever group rickettsiosis imported into the United Kingdom and treated with ciprofloxacin: a case report. (18387179)
2008
14
Rocky Mountain spotted fever in Argentina. (18385370)
2008
15
Rocky Mountain spotted fever, Colombia. (18214179)
2007
16
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (17674321)
2007
17
Human spotted fever rickettsial infections. (15829206)
2005
18
Rocky Mountain Spotted Fever, another important cause of fever and rash. (15498625)
2004
19
Spotted-fever-group rickettsioses in north Asia. (14667766)
2003
20
Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever. (12353892)
2002
21
Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. (12200314)
2002
22
Rocky Mountain spotted fever: a review for the pediatrician. (11905289)
2002
23
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
24
Index of suspicion. Case 2. Rocky Mountain spotted fever. (10208089)
1999
25
Israeli spotted fever rickettsia (Rickettsia conorii complex) associated with human disease in Portugal. (10603225)
1999
26
Rocky mountain spotted fever. (9868640)
1998
27
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. (9866756)
1998
28
Long-term sequelae of Rocky Mountain spotted fever. (7619986)
1995
29
Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. (8143383)
1994
30
Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 1. Clinical and epidemiological features. (1986207)
1991
31
Rocky Mountain spotted fever--United States, 1988. (2501644)
1989
32
Rocky Mountain spotted fever: mimicry of appendicitis or acute surgical abdomen? (3728395)
1986
33
Rocky Mountain spotted fever--United States, 1985. (3083229)
1986
34
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
35
Neurogenic bladder in Rocky Mountain spotted fever. (6824406)
1983
36
Conjunctival hemorrhage and Rocky Mountain spotted fever. (7058380)
1982
37
Surveillance of Rocky Mountain spotted fever in the United States, 1978-1980. (7108278)
1982
38
Rocky mountain spotted fever in dogs and man. (7278854)
1981
39
The occurrence of eschars in Rocky Mountain spotted fever. (7240465)
1981
40
Rocky Mountain Spotted Fever. (7386797)
1980
41
Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. (96691)
1978
42
Rocky Mountain spotted fever in an infant: diagnosis in siblings. (685914)
1978
43
Early diagnosis of Rocky Mountain spotted fever. Use of primary monocyte culture technique. (814256)
1976
44
Rocky Mountain spotted fever: case presentation and general discussion. (1055501)
1975
45
Surveillance of Rocky Mountain spotted fever. (4740658)
1973
46
Anterior nongranulomatous uveitis associated with Rocky Mountain spotted fever. First report of a case. (5774294)
1969
47
HYPOFIBRINOGENEMIA IN ROCKY MOUNTAIN SPOTTED FEVER. REPORT OF A CASE. (14129057)
1964
48
Ecology of rocky mountain spotted fever in Western Montana. I. Isolation of Rickettsia rickettsii from wild mammals. (14041199)
1962
49
Ecology on Rocky Mountain spotted Fever: a basic research project now in process in Virginia. (13831260)
1961
50
Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever. (18013649)
1933

Variations for Spotted Fever

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Expression for genes affiliated with Spotted Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spotted Fever

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Pathways for genes affiliated with Spotted Fever

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Compounds for genes affiliated with Spotted Fever

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45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Spotted Fever according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1dipyrone45 1110.8G6PD, CHKB
2gssg459.8CHKB, G6PD
3gemfibrozil29 45 1111.8G6PD, CHKB
4guanidine hydrochloride459.7G6PD, CHKB
5malondialdehyde459.7G6PD, CHKB
6succinate459.7CHKB, G6PD
7uric acid45 2410.7CHKB, G6PD
8carnitine459.7G6PD, CHKB
9glucose 6-phosphate45 2410.7CHKB, G6PD
10alpha tocopherol459.7G6PD, CHKB
11mannitol45 1110.7CHKB, G6PD
12vitamin-e459.5G6PD, THBD
13ptca459.5CHKB, THBD
14glycerol45 24 1111.4CHKB, G6PD
15raloxifene45 51 29 1112.4CHKB, THBD
16fluvastatin45 51 29 1112.4CHKB, THBD
17nifedipine45 29 51 1112.4G6PD, THBD
18neopterin459.4THBD, CHKB
19theophylline45 29 24 1112.4CHKB, THBD
20pravastatin45 51 29 24 1113.4CHKB, THBD
21atorvastatin45 51 29 24 1113.4THBD, CHKB
22prednisolone45 29 1111.3THBD, CHKB
23cyclophosphamide45 51 1111.3G6PD, THBD
24pyruvate459.3CHKB, G6PD
25agarose459.3CHKB, THBD
26valine459.3G6PD, THBD
27simvastatin45 51 61 29 24 1114.3THBD, CHKB
28endotoxin459.2THBD, CHKB
29dmso459.2G6PD, THBD
30phosphatidylserine45 29 1111.1THBD, G6PD
31folate459.1THBD, AFF2, G6PD
32oxygen45 2410.1CCL13, CHKB, G6PD
33phosphatidylcholine459.0G6PD, THBD
34polyethylene glycol459.0CHKB, G6PD, THBD
35azathioprine45 3 51 1112.0CHKB, G6PD, THBD
36citrate459.0CHKB, G6PD, THBD
37thyroxine45 249.9CHKB, G6PD, THBD
38aspirin45 51 29 2411.9CHKB, G6PD, THBD
39ascorbic acid45 249.9THBD, G6PD, CHKB
40lactate458.9CHKB, G6PD, THBD
41creatinine458.9CHKB, G6PD, THBD
42aspartate458.9THBD, G6PD, CHKB
43h2o2458.9THBD, G6PD, CHKB
44steroid458.9THBD, CHKB, CCL13
45dexamethasone45 51 29 1111.9CCL13, CHKB, THBD
46estrogen458.8THBD, G6PD, CHKB
47atp45 299.8CHKB, G6PD, THBD
48nacl458.7CHKB, THBD
49glucose458.7CHKB, G6PD, THBD

GO Terms for genes affiliated with Spotted Fever

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Products for genes affiliated with Spotted Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spotted Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet