MCID: SPT005
MIFTS: 53

Spotted Fever malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Spotted Fever

Summaries for Spotted Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted_by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary : Spotted Fever, also known as spotted fevers, is related to rickettsialpox and israeli tick typhus, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and testes, and related phenotypes are cardiovascular system and cellular

Wikipedia : 71 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
id Related Disease Score Top Affiliating Genes
1 rickettsialpox 32.6 IFNG IL10 TNF
2 israeli tick typhus 32.3 CCL5 IFNG
3 tularemia 30.0 IFNG IL10 TNF
4 hepatitis 29.9 IFNG IL10 TNF
5 rocky mountain spotted fever 12.6
6 japanese spotted fever 12.4
7 far eastern spotted fever 12.3
8 flinders island spotted fever 12.3
9 astrakhan spotted fever 12.2
10 rickettsia parkeri spotted fever 12.1
11 boutonneuse fever 12.0
12 african tick-bite fever 11.7
13 siberian tick typhus 11.6
14 queensland tick typhus 11.5
15 aneruptive fever 11.4
16 endemic typhus 11.2
17 colorado tick fever 11.0
18 indian tick typhus 11.0
19 stocco dos santos syndrome 10.3 IFNG TNF
20 asymptomatic neurosyphilis 10.3 IFNG IL10
21 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
22 autosomal dominant deafness-onychodystrophy syndrome 10.3 IFNG TNF
23 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 TNF
24 distal trisomy 14q 10.2 IFNG TNF
25 lagophthalmos 10.2 IL10 TNF
26 immunodeficiency due to a late component of complement deficiency 10.2 CXCL10 IFNG IL10
27 conidiobolomycosis 10.2 IL10 TNF
28 periodontosis 10.2 CXCL10 IFNG TNF
29 rosacea 10.2 IFNG IL10 SLC17A5
30 urogenital adysplasia 10.2 THBD VWF
31 proximal symphalangism 10.2 CXCL10 IFNG IL10
32 tungiasis 10.2 IFNG IL10
33 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG IL10 TNF
34 degenerative disc disease 10.2 TNF VWF
35 plantar wart 10.2 IFNG IL10 TNF
36 parkinson disease 11 10.2 IFNG IL10 TNF
37 cyclosporiasis 10.2 IFNG IL10 TNF
38 neurotic disorder 10.2 IFNG IL10 TNF
39 senile reticular retinal degeneration 10.2 IFNG IL10 TNF
40 conduct disorder 10.2 IFNG IL10 TNF
41 pancreatic signet ring cell adenocarcinoma 10.2 IFNG IL10 TNF
42 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 CCL5 TNF
43 acute myeloid leukemia with recurrent genetic anomaly 10.2 IFNG IL10 TNF
44 microcephaly 10.2 IFNG IL10 TNF
45 plummer's disease 10.1 IFNG IL10 TNF
46 orbital osteomyelitis 10.1 IFNG IL10 TNF
47 disease of mental health 10.1 IFNG IL10 TNF
48 follicular adenoma 10.1 IFNG IL10 TNF
49 myiasis 10.1 IFNG IL10 TNF
50 heart conduction disease 10.1 IFNG IL10 TNF

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to Spotted Fever

Symptoms & Phenotypes for Spotted Fever

Symptoms:

12
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

MGI Mouse Phenotypes related to Spotted Fever:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 TNF VWF CXCL10 F2 HTRA1 IFNG
2 cellular MP:0005384 10.1 CXCL10 IFNG IL10 NOS2 SLC17A5 THBD
3 hematopoietic system MP:0005397 10.09 CCL5 CXCL10 F2 IFNG IL10 NOS2
4 growth/size/body region MP:0005378 10.06 F2 HTRA1 IFNG IL10 NOS2 SLC17A5
5 homeostasis/metabolism MP:0005376 10.06 TNF VWF CXCL10 F2 IFNG IL10
6 digestive/alimentary MP:0005381 10.02 F2 IFNG IL10 NOS2 THBD TNF
7 immune system MP:0005387 10.02 CCL5 CXCL10 F2 IFNG IL10 NOS2
8 mortality/aging MP:0010768 9.91 CXCL10 F2 IFNG IL10 NOS2 SLC17A5
9 nervous system MP:0003631 9.81 F2 IFNG IL10 NOS2 SLC17A5 THBD
10 integument MP:0010771 9.8 NOS2 THBD TNF F2 IFNG IL10
11 respiratory system MP:0005388 9.43 F2 IFNG IL10 NOS2 THBD TNF
12 vision/eye MP:0005391 9.1 HTRA1 IFNG IL10 NOS2 SLC17A5 TNF

Drugs & Therapeutics for Spotted Fever

Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


id Name Status NCT ID Phase
1 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
2 300 Antibody Diagnostic Test Kit Unknown status NCT01646411

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

Anatomical Context for Spotted Fever

MalaCards organs/tissues related to Spotted Fever:

39
Skin, Endothelial, Testes, T Cells, Monocytes, Liver, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Spotted Fever:

18
Endothelial Cell Of Artery Or

Publications for Spotted Fever

Articles related to Spotted Fever:

(show top 50) (show all 1028)
id Title Authors Year
1
Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. ( 28500808 )
2017
2
Rocky Mountain Spotted Fever. ( 28055518 )
2017
3
High seroprevalence for indigenous spotted fever group rickettsiae in forestry workers from the federal state of Brandenburg, Eastern Germany. ( 27793612 )
2017
4
The Detection of Spotted Fever Group Rickettsia DNA in Tick Samples From Pastoral Communities in Kenya. ( 28073909 )
2017
5
Molecular detection of Rickettsia rhipicephali and other spotted fever group Rickettsia species in Amblyomma ticks infesting wild birds in the state of Minas Gerais, Brazil. ( 27745888 )
2017
6
Association of the occurrence of Brazilian spotted fever and Atlantic rain forest fragmentation in the SALo Paulo metropolitan region, Brazil. ( 27880877 )
2017
7
Sennetsu Neorickettsiosis, Spotted Fever Group, and Typhus Group Rickettsioses in Three Provinces in Thailand. ( 27139448 )
2016
8
Fundus Examination: A Key to Spot the Spotted Fever! ( 26944429 )
2016
9
Probability of occurrence of the Brazilian spotted fever in northeast of ParanA! state, Brazil. ( 27925056 )
2016
10
Retrospective Study of Rocky Mountain Spotted Fever in Children. ( 27990680 )
2016
11
Severe Israeli spotted fever with multiorgan failure in a child. ( 26905298 )
2016
12
Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells. ( 27525249 )
2016
13
Comparative value of blood and skin samples for diagnosis of spotted fever group rickettsial infection in model animals. ( 27282078 )
2016
14
Kampinos National Park: a risk area for spotted fever group rickettsioses, central Poland? ( 27631765 )
2016
15
Molecular detection of spotted fever group rickettsiae in ticks removed from humans in Turkey. ( 27131413 )
2016
16
Hierarchical Bayesian Spatio-Temporal Analysis of Climatic and Socio-Economic Determinants of Rocky Mountain Spotted Fever. ( 26942604 )
2016
17
Genetic identification of Rickettsia sp. strain Atlantic rainforest in an endemic area of a mild spotted fever in Rio Grande do Sul state, Southern Brazil. ( 27338183 )
2016
18
Exposure of dogs to spotted fever group rickettsiae in urban sites associated with human rickettsioses in Costa Rica. ( 26995323 )
2016
19
Emerging spotted fever group rickettsiae in ticks, northwestern China. ( 27554852 )
2016
20
Analysis of Amblyomma sculptum haplotypes in an area endemic for Brazilian spotted fever. ( 27120044 )
2016
21
Rickettsia sp. Strain Atlantic Rainforest Infection in a Patient from a Spotted Fever-Endemic Area in Southern Brazil. ( 27325804 )
2016
22
Estimation of Rickettsia rickettsii copy number in the blood of patients with Rocky Mountain spotted fever suggests cyclic diurnal trends in bacteraemia. ( 26724989 )
2016
23
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. ( 27508322 )
2016
24
Molecular detection of spotted fever group rickettsiae in Amblyomma variegatum ticks from Benin. ( 27150592 )
2016
25
Possible Case of Novel Spotted Fever Group Rickettsiosis in Traveler Returning to Japan from India. ( 27192498 )
2016
26
Ecology of a tick-borne spotted fever in southern Brazil. ( 27392739 )
2016
27
First report of spotted fever group Rickettsia in Cuba. ( 27378408 )
2016
28
Spotted fever group rickettsiae in ticks of migratory birds in Romania. ( 27207258 )
2016
29
Spotted Fever Group Rickettsioses and Murine Typhus in a Malaysian Teaching Hospital. ( 27402519 )
2016
30
Novel spotted fever group rickettsiae in Haemaphysalis qinghaiensis ticks from Gansu, Northwest China. ( 26968160 )
2016
31
Severe Fever with Thrombocytopenia Syndrome Complicated by Co-infection with Spotted Fever Group Rickettsiae, China. ( 27767921 )
2016
32
Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. ( 27380385 )
2016
33
Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. ( 27172113 )
2016
34
A fatal case of Brazilian spotted fever in a non-endemic area in Brazil: the importance of having health professionals who understand the disease and its areas of transmission. ( 27812666 )
2016
35
A Rare Case of Mediterranean Spotted Fever and Encephalitis. ( 28053795 )
2016
36
Human Infection with Novel Spotted Fever Group Rickettsia Genotype, China, 2015. ( 27869588 )
2016
37
Molecular detection and characterization of spotted fever group rickettsiae in ticks from Central Italy. ( 27365155 )
2016
38
Diversity of spotted fever group Rickettsia infection in hard ticks from Suifenhe, Chinese-Russian border. ( 26976703 )
2016
39
Distribution of Spotted Fever Group Rickettsiae in Hard Ticks (Ixodida: Ixodidae) from Panamanian Urban and Rural Environments (2007-2013). ( 27068930 )
2016
40
State of the art of diagnosis of rickettsial diseases: the use of blood specimens for diagnosis of scrub typhus, spotted fever group rickettsiosis, and murine typhus. ( 27429138 )
2016
41
Serologic evidence of the exposure of small mammals to spotted-fever Rickettsia and Rickettsia bellii in Minas Gerais, Brazil. ( 27031460 )
2016
42
Detection of rickettsiae in fleas and ticks from areas of Costa Rica with history of spotted fever group rickettsioses. ( 27592065 )
2016
43
Spotted Fever Group Rickettsia in the Pampa Biome, Brazil, 2015-2016. ( 27767913 )
2016
44
An update on the epidemiological situation of spotted fever in Brazil. ( 27555867 )
2016
45
Notes from the Field: Community-Based Prevention of Rocky Mountain Spotted Fever - Sonora, Mexico, 2016. ( 27880753 )
2016
46
Scrub typhus and spotted fever among hospitalised children in South India: Clinical profile and serological epidemiology. ( 27514949 )
2016
47
Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee. ( 27022147 )
2016
48
Probable case of spotted fever group rickettsial infection in a new suspected endemic area, Colombia. ( 27614577 )
2016
49
Rickettsia (Rickettsiales: Rickettsiaceae) Vector Biodiversity in High Altitude Atlantic Forest Fragments Within a Semiarid Climate: A New Endemic Area of Spotted-Fever in Brazil. ( 27480099 )
2016
50
Rickettsia amblyommatis sp. nov.,a spotted fever group rickettsia associated with multiple species of Amblyomma ticks in North and South America. ( 27638476 )
2016

Variations for Spotted Fever

Expression for Spotted Fever

Search GEO for disease gene expression data for Spotted Fever.

Pathways for Spotted Fever

Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CCL5 CXCL10 F2 IFNG IL10 NOS2
2
Show member pathways
13.11 CCL5 CXCL10 IFNG IL10 NOS2 TNF
3
Show member pathways
12.67 CCL5 CXCL10 IFNG TNF
4
Show member pathways
12.6 CCL5 CXCL10 IFNG TNF
5
Show member pathways
12.51 CCL5 CXCL10 IFNG IL10 NOS2 TNF
6
Show member pathways
12.33 F2 IFNG IL10 NOS2 TNF
7
Show member pathways
12.22 CCL5 F2 IFNG TNF
8 12.22 CCL5 CXCL10 IFNG IL10 TNF
9
Show member pathways
12.15 IFNG NOS2 TNF
10
Show member pathways
12.13 IFNG IL10 NOS2 TNF
11 12.09 IFNG IL10 NOS2 TNF
12 12.06 IFNG NOS2 TNF
13
Show member pathways
12.05 F2 THBD VWF
14
Show member pathways
12.03 IFNG IL10 TNF
15
Show member pathways
12.03 CXCL10 IFNG NOS2 TNF
16 11.97 F2 THBD VWF
17 11.97 IFNG THBD TNF
18 11.89 IFNG IL10 TNF
19 11.87 IL10 NOS2 TNF
20 11.84 CCL5 CXCL10 TNF
21
Show member pathways
11.83 IFNG IL10 TNF
22 11.75 CCL5 IFNG TNF
23 11.75 CXCL10 IFNG NOS2 TNF
24 11.69 IFNG IL10 TNF
25 11.66 IL10 NOS2 TNF
26 11.62 IL10 NOS2 TNF
27
Show member pathways
11.57 IFNG NOS2 TNF
28 11.44 IFNG IL10 TNF
29 11.44 IFNG IL10 NOS2 TNF
30 11.42 IFNG NOS2 TNF
31
Show member pathways
11.3 IFNG IL10 TNF
32 11.24 CXCL10 IFNG NOS2
33 11.2 IFNG IL10 TNF
34 11.14 IFNG IL10 THBD TNF
35 11.1 IFNG IL10
36 11.09 IFNG IL10 TNF
37 11.08 F2 IFNG
38 11.08 CCL5 CXCL10 IL10 TNF
39 11.05 CCL5 TNF
40 10.61 CCL5 CXCL10 IL10 TNF

GO Terms for Spotted Fever

Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL5 CXCL10 F2 HTRA1 IFNG IL10
2 external side of plasma membrane GO:0009897 9.46 CXCL10 F2 IFNG TNF
3 extracellular space GO:0005615 9.23 CCL5 CXCL10 F2 HTRA1 IFNG IL10

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.91 CCL5 CXCL10 IL10 TNF
2 immune response GO:0006955 9.89 CCL5 CXCL10 IFNG IL10 TNF
3 negative regulation of gene expression GO:0010629 9.83 IFNG NOS2 TNF
4 defense response to bacterium GO:0042742 9.83 IFNG IL10 NOS2 TNF
5 positive regulation of protein phosphorylation GO:0001934 9.82 F2 IFNG TNF
6 response to lipopolysaccharide GO:0032496 9.76 CXCL10 IL10 NOS2 THBD
7 hemostasis GO:0007599 9.69 F2 THBD VWF
8 protein import into nucleus, translocation GO:0000060 9.67 IFNG TNF
9 negative regulation of mitotic cell cycle GO:0045930 9.67 IL10 TNF
10 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.66 CXCL10 F2
11 negative regulation of interleukin-6 production GO:0032715 9.66 IL10 TNF
12 positive regulation of protein complex assembly GO:0031334 9.65 IFNG TNF
13 negative regulation of myoblast differentiation GO:0045662 9.64 CXCL10 TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.64 IFNG TNF
15 defense response to protozoan GO:0042832 9.63 IFNG IL10
16 blood coagulation, intrinsic pathway GO:0007597 9.63 F2 VWF
17 positive regulation of monocyte chemotaxis GO:0090026 9.62 CCL5 CXCL10
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.62 IL10 TNF
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG TNF
20 positive regulation of cell adhesion GO:0045785 9.61 CCL5 IFNG TNF
21 positive regulation of T cell migration GO:2000406 9.6 CCL5 CXCL10
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL10 TNF
23 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IFNG TNF
24 negative regulation of fibrinolysis GO:0051918 9.58 F2 THBD
25 negative regulation of platelet activation GO:0010544 9.57 F2 THBD
26 endothelial cell apoptotic process GO:0072577 9.56 IL10 TNF
27 response to virus GO:0009615 9.56 CCL5 CXCL10 IFNG TNF
28 positive regulation of MHC class II biosynthetic process GO:0045348 9.55 IFNG IL10
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.54 IL10 TNF
30 positive regulation of killing of cells of other organism GO:0051712 9.48 IFNG NOS2
31 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
33 negative regulation of growth of symbiont in host GO:0044130 9.33 IFNG IL10 TNF
34 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
35 regulation of insulin secretion GO:0050796 9.26 CCL5 IFNG NOS2 TNF
36 cellular response to lipopolysaccharide GO:0071222 9.02 CXCL10 IFNG IL10 NOS2 TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 CXCL10 IFNG IL10 TNF

Sources for Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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