Spotted Fever malady

Disease Ontology: A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in rickettsia, which is transmitted by ticks and mites. the infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. a distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.⁶

MalaCards: Spotted Fever, also known as spotted fevers, is related to rocky mountain spotted fever and japanese spotted fever, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is HTRA1 (HtrA serine peptidase 1), and among its related pathways are Amoebiasis and Endothelin-1 Signaling Pathway. The compounds polyethylene glycol and calcitriol have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and monocytes, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Wikipedia: A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by...⁴⁴ more...

Aliases & Descriptions:

spotted fever 6 30 8 spotted fevers 32 43

spotted fever group rickettsial disease (disorder) 6

Diseases related to spotted fever by text searches and GeneDecks gene sharing:

(show top 50)    (show all 479)

id	Related Disease	Score	Top Affiliating Genes
1	rocky mountain spotted fever	33.9	KHDRBS3, LARS2, SLC17A5
2	japanese spotted fever	33.5	CHKB, YAP1, IFT122
3	boutonneuse fever	31.7	IRS4, G6PD
4	endemic typhus	30.7	IFT122, HTRA1
5	african tick-bite fever	30.2	IL10, CCL5, IFNG
6	hydrops fetalis	13.5	IGHV4-39, G6PD, SLC17A5
7	neonatal intrahepatic cholestasis caused by citrin deficiency	13.4	F2, SLC17A5
8	non-a-e hepatitis	13.4	F2, SLC17A5
9	sydenham's chorea	13.4	CXCL10, CXCL9
10	plasmodium vivax malaria	13.3	IFNG, G6PD, THBD
11	bilirubin metabolic disorder	13.3	F2, G6PD, SLC17A5
12	thromboembolism	13.2	F2, G6PD, THBD
13	respiratory failure	13.1	CCL5, G6PD, CXCL10
14	diabetic ketoacidosis	13.1	CHKB, IL10, G6PD
15	peripheral arterial occlusive disease	13.1	F2, THBD, CS
16	hyperlipoproteinemia type iii	13.1	TNF, G6PD, SLC17A5
17	pericarditis	13.1	TNF, G6PD, SLC17A5
18	galactosemia	13.1	CHKB, F2, SLC17A5
19	adult-onset still's disease	13.1	TNF, G6PD, THBD
20	cutaneous leishmaniasis	13.0	IL10, IFNG
21	tuberculous uveitis	13.0	IFNG, TNF
22	buruli ulcer disease	13.0	IL10, IFNG
23	tuberculoid leprosy	13.0	IL10, IFNG
24	punctate inner choroidopathy	13.0	IL10, TNF
25	arterial occlusive disease	12.9	F2, THBD, CS
26	meningoencephalitis	12.9	CHKB, CCL5, TNF, SLC17A5
27	thrombotic thrombocytopenic purpura, acquired	12.9	IFNG, F2, THBD, SLC17A5
28	eosinophilic fasciitis	12.9	IL10, IFNG
29	primary systemic mycosis	12.9	IL10, IGHV4-39, TNF
30	compartment syndrome	12.9	CHKB, F2, TNF, SLC17A5
31	histoplasmosis	12.8	IFNG, TNF, SLC17A5
32	cat-scratch disease	12.8	IGHV4-39, HTRA1, TNF, PPP1R14A, CS
33	hepatitis d	12.8	IGHV4-39, F2, TNF, SLC17A5
34	crimean-congo hemorrhagic fever	12.8	IGHV4-39, F2, TNF, SLC17A5
35	yellow fever	12.8	CCL5, IGHV4-39, F2, CXCL10
36	panuveitis	12.8	IL10, TNF
37	churg-strauss syndrome	12.8	IL10, IFNG, THBD
38	sepsis	12.8	IL10, TNF
39	extrapulmonary tuberculosis	12.8	IL10, IFNG, CXCL9
40	meningococcal infection	12.8	IL10, TNF, G6PD
41	hepatic encephalopathy	12.8	F2, TNF, SLC17A5
42	adult respiratory distress syndrome	12.8	F2, TNF, THBD
43	obstructive jaundice	12.8	F2, TNF, THBD, SLC17A5
44	bcg infection	12.8	IFNG, TNF, CXCL10
45	chronic active epstein-barr virus infection	12.8	IL10, IFNG, IDO1
46	opportunistic bacterial infectious disease	12.8	IFNG, IDO1, TNF
47	cytomegalovirus retinitis	12.8	IFNG, IDO1, TNF
48	hepatitis e	12.8	IGHV4-39, IFNG, F2, G6PD, SLC17A5
49	listeriosis	12.8	IFNG, IDO1, TNF
50	multifocal motor neuropathy	12.7	IL10, IFNG

Symptoms: fever, headache, fatigue, muscle aches, maculopapular or petechial rash.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spotted fever:

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FMA organs/tissues related to spotted fever:

¹¹

MGI Mouse Phenotypes related to spotted fever:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.0	IDO1, CD200, BRD1
2	liver/biliary system phenotype	MP:0005370	9.2	IFNG, YAP1, BRD1
3	growth/size phenotype	MP:0005378	9.1	AFF2, THBD, IFT122, IRS4, YAP1, BRD1
4	embryogenesis phenotype	MP:0005380	8.9	G6PD, F2, IFT122, YAP1, BRD1
5	integument phenotype	MP:0010771	8.8	YAP1, IFNG, F2, AFF2
6	immune system phenotype	MP:0005387	8.4	CXCL10, TNF, F2, IFNG, CD200, YAP1
7	digestive/alimentary phenotype	MP:0005381	8.2	NOS2, F2, IFT122, IFNG, YAP1
8	nervous system phenotype	MP:0003631	7.8	THBD, CXCL10, SLC17A5, AFF2, G6PD, F2
9	homeostasis/metabolism phenotype	MP:0005376	7.1	SLC17A5, THBD, G6PD, NOS2, PTGS2, F2
10	vision/eye phenotype	MP:0005391	7.0	SLC17A5, NOS2, PTGS2, TNF, HTRA1, IFT122
11	cardiovascular system phenotype	MP:0005385	6.1	CXCL10, THBD, G6PD, NOS2, PTGS2, TNF
12	cellular phenotype	MP:0005384	5.0	BRD1, SLC17A5, CXCL10, THBD, G6PD, NOS2
13	mortality/aging	MP:0010768	4.9	AFF2, SLC17A5, CXCL9, CXCL10, THBD, G6PD

Articles related to spotted fever:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	Relevance of Interferon-gamma, Tumor Necrosis Factor-alpha and Interleukin 10 gene polymorphisms for Mediterranean Spotted Fever susceptibility. (19386798)	Forte G.I.... Mansueto S.	2009	TNF, IFNG, IL10
2	Rickettsial spotted fever in capoeirALo village, Itabi ra, Minas Gerais, Brazil. (18949349)	Vianna M.C.... Gennari S.M.	2008	HTRA1
3	Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (17674321)	de Sousa R.... Walker D.H.	2007	TNF, IFNG, NOS2
4	Detection of a novel spotted fever group rickettsia in Amblyomma parvum ticks (Acari: Ixodidae) from Argentina. (17768597)	Pacheco R.C.... Labruna M.B.	2007	HTRA1
5	Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. (16926398)	Rydkina E.... Sahni S.K.	2006	PTGS2
6	Characterization of spotted fever group rickettsiae in flea and tick specimens from northern Peru. (15528680)	Blair P.J.... Olson J.G.	2004	HTRA1
7	Clinical study of Japanese spotted fever and its aggravating factors. (12673413)	Kodama K.... Chikahira Y.	2003	CHKB
8	Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. (14507644)	Valbuena G.... Walker D.H.	2003	CXCL10, CXCL9
9	Macrolides in the treatment of children with Mediterranean spotted fever (12704264)	Cascio A.... Colomba C.	2002	G6PD
10	Plasma levels of tumor necrosis factor-alpha and interferon-gamma in Sicilian children with Mediterranean spotted fever. (9266285)	Cascio A.... Salsa L.	1997	IFNG
11	Predictors of prognosis and risk of acute renal failu re in patients with Rocky Mountain spotted fever. (9003109)	Conlon P.J.... Sexton D.J.	1996	SLC17A5
12	Demonstration of Rickettsia Conorii-induced coagulative and platelet activation in vivo in patients with Mediterranean spotted fever. (8584998)	DavA- G.... Mansueto S.	1995	F2
13	Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. (7691249)	George F.... Sampol J.	1993	THBD
14	Tumor necrosis factor alpha and prostaglandin E2 prod uction by human monocyte-derived macrophages infected with spotted fever group rickettsiae. (2378446)	Manor E.... Sarov I.	1990	TNF

Genes related to spotted fever according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	HTRA1	HtrA serine peptidase 1	11.0	Publications
2	LARS2	leucyl-tRNA synthetase 2, mitochondrial	11.0
3	KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	11.0
4	THBD	thrombomodulin	11.0	Publications
5	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
6	CHKB	choline kinase beta	11.0	Publications
7	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
8	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
9	RPA4	replication protein A4, 30kDa	11.0
10	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	11.0
11	PLEKHG4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	11.0
12	GPR162	G protein-coupled receptor 162	11.0
13	IRS4	insulin receptor substrate 4	11.0
14	CD200	CD200 molecule	11.0
15	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
16	BRD1	bromodomain containing 1	11.0	Disorders
17	IFT122	intraflagellar transport 122 homolog (Chlamydomonas)	11.0
18	YAP1	Yes-associated protein 1	11.0
19	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
20	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
21	CS	citrate synthase	11.0
22	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
23	AFF2	AF4/FMR2 family, member 2	11.0
24	TNF	tumor necrosis factor	11.0	Publications
25	IFNG	interferon, gamma	11.0	Publications
26	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
27	F2	coagulation factor II (thrombin)	11.0	Publications
28	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
29	IL10	interleukin 10	11.0	Publications

Pathways related to spotted fever according to GeneDecks:

(show all 30)

id	Pathway	Score	Top Affiliating Genes
1	Amoebiasis20	9.9	NOS2
2	Endothelin-1 Signaling Pathway36	9.5	CXCL9, CXCL10, CCL5, IL10
3	Toll-like receptor signaling pathway20	9.4	CCL5, TNF, CXCL10, CXCL9
4	Cytokine Network36	9.3	TNF, IFNG, IL10
5	Allograft rejection20	9.2	IL10, IFNG, TNF
6	THC Differentiation Pathway36	9.2	TNF, IFNG, IL10
7	ERK Signaling36	9.1	CXCL9, CXCL10, PPP1R14A, CCL5, IL10
8	African trypanosomiasis20	9.1	TNF, IDO1, IFNG, IL10
9	Th1 Differentiation37	8.8	TNF, IFNG, IL10
10	Immune response_MIF-mediated glucocorticoid regulation41	8.6	NOS2, PTGS2, TNF, IFNG
11	Immune response MIF-mediated glucocorticoid regulation10	8.6	NOS2, PTGS2, TNF, IFNG
12	Immune response_MIF in innate immunity response41	8.6	NOS2, PTGS2, TNF, IFNG
13	Immune response MIF in innate immunity response10	8.6	NOS2, PTGS2, TNF, IFNG
14	Toxoplasmosis20	8.3	IL10, IFNG, TNF, NOS2
15	Chagas disease (American trypanosomiasis)20	8.2	NOS2, TNF, IFNG, CCL5, IL10
16	Leishmaniasis20	8.1	NOS2, PTGS2, TNF, IFNG, IL10
17	Antioxidant Action of Vitamin-C36	INF	CXCL9, CXCL10, TNF, CCL5, , IL10
18	Akt Signaling36	INF	CXCL9, CXCL10, TNF, CCL5, , IL10
19	PAK Pathway36	INF	CXCL9, CXCL10, TNF, CCL5, , IL10
20	IL-6 Pathway36	INF	CXCL9, CXCL10, PPP1R14A, TNF, CCL5,
21	RAR-Gamma-RXR-Alpha Degradation36	INF	, CCL5, CXCL9
22	MIF Mediated Glucocorticoid Regulation36	INF	IL10, CXCL9, CXCL10, PTGS2, TNF, CCL5
23	STAT3 Pathway36	INF	CXCL9, CXCL10, TNF, CCL5, , IL10
24	p38 Signaling36	INF	CXCL9, CXCL10, TNF, CCL5, , IL10
25	MIF Regulation of Innate Immune Cells36	INF	CXCL9, CXCL10, PTGS2, TNF, CCL5,
26	all-trans-Retinoic Acid Signaling in Brain36	INF	CXCL9, CXCL10, PTGS2, TNF, CCL5,
27	Cytokine-cytokine receptor interaction20	INF	CXCL9, CXCL10, TNF, IFNG, CCL5,
28	Rho Family GTPases36	INF	CXCL9, CXCL10, TNF, CCL5, , IL10
29	PEDF Induced Signaling36	INF	CXCL9, CXCL10, TNF, CCL5, , IL10
30	SOCS Pathway36	INF	IRS4, IL10, , CCL5

Compounds related to spotted fever according to GeneDecks:

(show top 50)    (show all 122)

id	Compound	Score	Top Affiliating Genes
1	polyethylene glycol32	10.3	CHKB, G6PD, THBD
2	calcitriol32 42 9 18 9	14.3	THBD, CCL5
3	n acetylcysteine32	10.1	F2, SLC17A5
4	h2o232	10.0	SLC17A5, CCL5, HTRA1
5	pge232	10.0	CXCL10, IDO1, CCL5
6	endotoxin32	9.9	CHKB, THBD, CXCL10, CXCL9, SLC17A5
7	creatinine32	9.7	CXCL10, THBD, CCL5, G6PD, CXCL9
8	vegf32	9.7	CCL5, CHKB, PTGS2, THBD
9	quinine32 9 9	11.5	IDO1, CXCL9, SLC17A5, IL10, G6PD
10	azathioprine32 34 9 9	12.4	IL10, G6PD, CHKB, THBD, CCL5
11	ascorbic acid32 18	10.4	SLC17A5, G6PD, CHKB, CS
12	interferon gamma32	9.3	IL10, IFNG, TNF
13	atorvastatin32 34 9 18 9	13.3	SLC17A5, THBD, TNF, IL10, CHKB
14	polymyxin b32	9.3	IL10, THBD, TNF, IFNG
15	ribavirin32 34 9 9	12.2	IFNG, IL10, SLC17A5, G6PD, CXCL10
16	fluticasone propionate32 42 9 9	12.2	CXCL10, TNF, CCL5, IFNG
17	indoleamine32	9.2	TNF, IDO1, IFNG, IL10
18	groalpha32	9.1	CXCL9, CCL5, CXCL10, TNF, IL10
19	poly(i-c)32	9.1	CXCL10, CCL5, TNF, IDO1, IFNG
20	gm-csf32	9.0	IL10, CCL5, TNF, IFNG
21	prednisolone32 9 9	11.0	IFNG, CHKB, SLC17A5, THBD, IL10, TNF
22	2,5-oligoadenylate32	8.9	IDO1, IL10, TNF, IFNG, CXCL10
23	infliximab32 9 9	10.9	CXCL10, TNF, IDO1, IFNG, IL10
24	aspirin32 34 18	10.8	G6PD, CHKB, CCL5, F2, PTGS2, THBD
25	vesnarinone32	8.8	NOS2, IFNG, TNF
26	taurine chloramine32	8.7	TNF, IFNG, NOS2
27	il 1032	8.6	IL10, CCL5, IFNG, CXCL9, TNF, CXCL10
28	ccl332	8.6	IL10, CXCL9, CXCL10, TNF, IFNG, CCL5
29	parthenolide32	8.6	NOS2, IFNG, PTGS2, TNF
30	hydrocortisone32 9 9	10.6	IL10, CCL5, IFNG, TNF, CXCL10
31	tacrolimus32 34 9 9	11.5	IFNG, TNF, CHKB, SLC17A5, IL10, CCL5
32	thalidomide32 42 9 9	11.5	CCL5, IL10, THBD, PTGS2, TNF, IFNG
33	methotrexate32 34 42 9 9	12.5	SLC17A5, F2, TNF, CHKB, CCL5, IL10
34	lactate32	8.5	CS, F2, TNF, THBD, G6PD, SLC17A5
35	neopterin32	8.5	CXCL10, THBD, IFNG, IDO1, IL10, TNF
36	silymarin32	8.4	SLC17A5, PTGS2, NOS2, F2
37	polyinosinic-polycytidylic acid32	8.4	CXCL10, IL10, IFNG, TNF, NOS2
38	triptolide32	8.3	CCL5, IFNG, NOS2, PTGS2, TNF
39	alanine32	8.3	KHDRBS3, CHKB, SLC17A5, CS, THBD, CXCL10
40	pdtc32	8.3	NOS2, IFNG, PTGS2, TNF, CCL5
41	egcg32	8.2	PTGS2, CCL5, TNF, G6PD, NOS2
42	15-deoxy-delta-12,14-prostaglandin j232	8.1	IL10, PTGS2, TNF, IFNG, NOS2
43	simvastatin32 34 42 9 18 9	13.1	TNF, THBD, SLC17A5, F2, IFNG, CCL5
44	cyclosporin a32 42	8.7	CS, THBD, SLC17A5, CHKB, TNF, F2
45	cycloheximide32	7.0	IL10, CXCL10, THBD, NOS2, TNF, IDO1
46	nitric oxide32 9 18 9	9.2	CCL5, IL10, CHKB, SLC17A5, TNF, IFNG
47	tarc32	INF	, CXCL9, CXCL10, TNF, IFNG, CCL5
48	histamine32 18	INF	PPP1R14A, CXCL9, TNF, THBD, CXCL10, IFNG
49	rantes32	INF	, CXCL10, CXCL9, CCL5, IFNG, IDO1
50	dexamethasone32 42 34 9 9	INF	THBD, NOS2, CS, CXCL9, PTGS2, TNF

Cellular components related to spotted fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	INF	IL10, CXCL10, THBD, TNF, F2, HTRA1

Biological processes related to spotted fever according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of T cell apoptotic process	GO:070233	10.1	IDO1, CCL5
2	positive regulation of vitamin D biosynthetic process	GO:060557	9.9	IFNG, TNF
3	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.8	TNF, IFNG
4	receptor biosynthetic process	GO:032800	9.7	TNF, IL10
5	positive regulation of osteoclast differentiation	GO:045672	9.6	CCL5, IFNG, TNF
6	positive regulation of fever generation	GO:031622	9.5	PTGS2, TNF, CCL5
7	response to activity	GO:014823	9.4	TNF, CCL5, IL10
8	negative regulation of growth of symbiont in host	GO:044130	9.4	IL10, IFNG, TNF
9	positive regulation of killing of cells of other organism	GO:051712	9.4	NOS2, IFNG
10	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	IFNG, TNF, PTGS2
11	negative regulation of cytokine secretion involved in immune response	GO:002740	9.2	TNF, IL10
12	response to lipopolysaccharide	GO:032496	9.2	CXCL10, THBD, PTGS2, IDO1
13	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	CCL5, TNF, PTGS2
14	response to glucocorticoid stimulus	GO:051384	9.0	PTGS2, TNF, CCL5, IL10
15	response to drug	GO:042493	8.2	IL10, CCL5, IFNG, TNF, PTGS2
16	inflammatory response	GO:006954	INF	IL10, , CCL5, TNF, PTGS2, CXCL10
17	cell-cell signaling	GO:007267	INF	CXCL9, CXCL10, CCL5, , IL10
18	chemotaxis	GO:006935	INF	, CCL5, CXCL10, CXCL9

Molecular functions related to spotted fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	INF	, CCL5, CXCL10, CXCL9