MCID: SPT005
MIFTS: 57

Spotted Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Spotted Fever

Summaries for Spotted Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted_by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary : Spotted Fever, also known as spotted fevers, is related to japanese spotted fever and boutonneuse fever, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 japanese spotted fever 34.0 AFF2 CXCL10
2 boutonneuse fever 33.6 AFF2 THBD
3 african tick-bite fever 33.1 CCL5 IFNG
4 q fever 30.5 IFNG IL10 TNF
5 meningitis 30.2 IFNG IL10 TNF
6 vasculitis 29.9 THBD TNF VWF
7 crohn's disease 29.8 IFNG IL10 TNF
8 connective tissue disease 29.7 IFNG IL10 TNF
9 adult respiratory distress syndrome 29.7 F2 IL10 TNF
10 uveitis 29.4 CXCL10 IFNG IL10 TNF
11 stroke, ischemic 29.1 F2 THBD VWF
12 arthritis 29.1 IFNG IL10 PTGS2 TNF
13 purpura 29.0 F2 THBD TNF VWF
14 rocky mountain spotted fever 12.7
15 far eastern spotted fever 12.4
16 flinders island spotted fever 12.4
17 astrakhan spotted fever 12.3
18 rickettsia parkeri spotted fever 12.2
19 queensland tick typhus 11.8
20 siberian tick typhus 11.8
21 rickettsialpox 11.7
22 israeli tick typhus 11.5
23 aneruptive fever 11.5
24 endemic typhus 11.4
25 colorado tick fever 11.1
26 indian tick typhus 11.1
27 punctate inner choroidopathy 10.5 IL10 TNF
28 tropical endomyocardial fibrosis 10.5 IL10 TNF
29 staphylococcal toxic shock syndrome 10.5 IFNG TNF
30 autoimmune myocarditis 10.5 IFNG TNF
31 cat-scratch disease 10.5 HTRA1 IFNG
32 chronic beryllium disease 10.5 IFNG TNF
33 trichosporonosis 10.5 IFNG TNF
34 microscopic polyangiitis 10.5 IL10 TNF
35 tungiasis 10.5 IL10 TNF
36 endomyocardial fibrosis 10.5 IL10 TNF
37 hyperlucent lung 10.5 IFNG IL10
38 transient hypogammaglobulinemia 10.5 IL10 TNF
39 sporotrichosis 10.4 IFNG IL10
40 mucocutaneous leishmaniasis 10.4 IL10 TNF
41 idiopathic achalasia 10.4 IL10 TNF
42 trichuriasis 10.4 IL10 TNF
43 immune suppression 10.4 IFNG IL10
44 baylisascariasis 10.4 IFNG IL10
45 crohn's colitis 10.4 IFNG TNF
46 chronic graft versus host disease 10.4 IFNG IL10
47 unilateral absence of a pulmonary artery 10.4 THBD VWF
48 microscopic colitis 10.4 IFNG TNF
49 meconium aspiration syndrome 10.4 IFNG TNF
50 central nervous system vasculitis 10.4 IFNG TNF

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to Spotted Fever

Symptoms & Phenotypes for Spotted Fever

Symptoms:

12
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

MGI Mouse Phenotypes related to Spotted Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 HTRA1 IFNG TNF IL10 VWF CXCL10
2 hematopoietic system MP:0005397 9.97 IFNG TNF IL10 CCL5 CXCL10 PTGS2
3 digestive/alimentary MP:0005381 9.95 IFNG TNF IL10 PTGS2 F2 THBD
4 immune system MP:0005387 9.91 THBD IFNG TNF IL10 CCL5 CXCL10
5 embryo MP:0005380 9.85 THBD IFNG TNF IL10 PTGS2 F2
6 integument MP:0010771 9.63 F2 THBD IFNG TNF IL10 PTGS2
7 nervous system MP:0003631 9.56 THBD IFNG TNF IL10 CXCL10 PTGS2
8 respiratory system MP:0005388 9.1 THBD IFNG TNF IL10 PTGS2 F2

Drugs & Therapeutics for Spotted Fever

Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins
3 Immunoglobulin A
4 Immunoglobulin M

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
2 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
3 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

Anatomical Context for Spotted Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Spotted Fever:

18
Endothelial Cell Of Artery Or

MalaCards organs/tissues related to Spotted Fever:

38
Skin, Endothelial, Testes, Liver, T Cells, Brain, Monocytes

Publications for Spotted Fever

Articles related to Spotted Fever:

(show top 50) (show all 1064)
# Title Authors Year
1
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
2
Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia. ( 29054570 )
2018
3
Two cases of Japanese spotted fever infected in Rokko mountain near urban area of southern Hyogo Prefecture. ( 29315729 )
2018
4
Development of a loop-mediated isothermal amplification (LAMP) assay for rapid screening of ticks and fleas for spotted fever group rickettsia. ( 29390021 )
2018
5
Molecular prevalence of spotted fever group rickettsiae in ticks from Qinghai Province, northwestern China. ( 29107656 )
2018
6
Case Report: Family Cluster of Japanese Spotted Fever. ( 29363442 )
2018
7
Identification and molecular characterization of spotted fever group rickettsiae in ticks collected from farm ruminants in Lebanon. ( 29054546 )
2018
8
Confirming Rickettsia rickettsii as the etiological agent of lethal spotted fever group rickettsiosis in human patients from EspA-rito Santo state, Brazil. ( 29371125 )
2018
9
Seroprevalence of spotted fever group (SFG) rickettsiae infection in domestic ruminants in Khartoum State, Sudan. ( 28713577 )
2017
10
Immune Thrombocytopenia as a Consequence of Rocky Mountain Spotted Fever. ( 29279696 )
2017
11
Spotted fever group rickettsiae associated with ixodid ticks in wild environment in Southern Italy. ( 29047217 )
2017
12
Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. ( 28500808 )
2017
13
High seroprevalence for indigenous spotted fever group rickettsiae in forestry workers from the federal state of Brandenburg, Eastern Germany. ( 27793612 )
2017
14
Spotted fever rickettsiae and tuberculous meningitis dual infection presenting as acute encephalitis syndrome: A fatal case report. ( 28748844 )
2017
15
Rocky Mountain Spotted Fever. ( 28055518 )
2017
16
Rickettsia australis and Queensland Tick Typhus: A Rickettsial Spotted Fever Group Infection in Australia. ( 28719297 )
2017
17
Spotted Fever Group Rickettsioses (SFGR): weather and incidence in Illinois. ( 28743316 )
2017
18
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. ( 28806774 )
2017
19
Black spot or A<tache noireA> in mediterranean spotted fever. ( 29173984 )
2017
20
Rickettsia gravesii sp. nov.: a novel spotted fever group rickettsia in Western Australian Amblyomma triguttatum triguttatum ticks. ( 28857025 )
2017
21
Association of the occurrence of Brazilian spotted fever and Atlantic rain forest fragmentation in the SALo Paulo metropolitan region, Brazil. ( 27880877 )
2017
22
Evidence of infection with Leptospira interrogans and spotted fever group rickettsiae among rodents in an urban area of Osaka City, Japan. ( 28529271 )
2017
23
Geographical Distribution of Japanese Spotted Fever and Tsutsugamushi Disease in Japan - Possible Effect of Environmental Temperature. ( 28250253 )
2017
24
Rocky Mountain spotted fever in Mexico: past, present, and future. ( 28365226 )
2017
25
Molecular detection of Rickettsia rhipicephali and other spotted fever group Rickettsia species in Amblyomma ticks infesting wild birds in the state of Minas Gerais, Brazil. ( 27745888 )
2017
26
Tick, Rickettsia Rickettsiae (Rocky Mountain Spotted Fever) ( 28613631 )
2017
27
Development of an electrochemical immunosensor for the diagnostic testing of spotted fever using synthetic peptides. ( 28886455 )
2017
28
Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma, Ehrlichia, and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. ( 28598270 )
2017
29
Fatal Rocky Mountain Spotted Fever along the United States-Mexico Border, 2013-2016. ( 28930006 )
2017
30
Spotted fever rickettsiae in wild-living rodents from south-western Poland. ( 28874204 )
2017
31
Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. ( 28775717 )
2017
32
Spotted Fever: Epidemiology and Vector-Rickettsia-Host Relationship in Rio de Janeiro State. ( 28424664 )
2017
33
Atypical Presentation Of Rickettsial Spotted Fever. ( 29331008 )
2017
34
Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia. ( 28722568 )
2017
35
Evaluation of a Spotted Fever Group Rickettsia Public Health Surveillance System in Tennessee. ( 28722610 )
2017
36
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. ( 28764157 )
2017
37
Rocky Mountain Spotted Fever and Pregnancy: Four Cases from Sonora, Mexico. ( 28722584 )
2017
38
Rickettsia sp. Strain NOD Infecting Ticks ( Amblyomma nodosum) in an Endemic Area of Spotted Fever in Brazil. ( 29261444 )
2017
39
Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing. ( 29048295 )
2017
40
Serological and molecular detection of spotted fever group Rickettsia in a group of pet dogs from Luanda, Angola. ( 28569177 )
2017
41
Evaluating the Surveillance System for Spotted Fever in Brazil Using Machine-Learning Techniques. ( 29250519 )
2017
42
Child Neurology: Rocky Mountain spotted fever encephalitis. ( 28289173 )
2017
43
The Detection of Spotted Fever Group Rickettsia DNA in Tick Samples From Pastoral Communities in Kenya. ( 28073909 )
2017
44
Severe Israeli spotted fever with multiorgan failure in a child. ( 26905298 )
2016
45
Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes. ( 27453284 )
2016
46
Sennetsu Neorickettsiosis, Spotted Fever Group, and Typhus Group Rickettsioses in Three Provinces in Thailand. ( 27139448 )
2016
47
Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells. ( 27525249 )
2016
48
A Rare Case of Mediterranean Spotted Fever and Encephalitis. ( 28053795 )
2016
49
Spotted fever group rickettsiae in ticks of migratory birds in Romania. ( 27207258 )
2016
50
A fatal case of Brazilian spotted fever in a non-endemic area in Brazil: the importance of having health professionals who understand the disease and its areas of transmission. ( 27812666 )
2016

Variations for Spotted Fever

Expression for Spotted Fever

Search GEO for disease gene expression data for Spotted Fever.

Pathways for Spotted Fever

Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 CCL5 CXCL10 F2 IFNG IL10 PTGS2
2
Show member pathways
13.11 CCL5 CXCL10 IFNG IL10 PTGS2 TNF
3
Show member pathways
12.66 CCL5 CXCL10 IFNG TNF
4
Show member pathways
12.58 CCL5 CXCL10 IFNG TNF
5
Show member pathways
12.44 F2 IFNG IL10 TNF
6
Show member pathways
12.26 CCL5 CXCL10 IFNG IL10 TNF
7
Show member pathways
12.18 CXCL10 IFNG PTGS2 TNF
8
Show member pathways
12.14 IFNG PTGS2 TNF
9 12.11 IFNG IL10 TNF
10
Show member pathways
12.1 IFNG IL10 PTGS2 TNF
11
Show member pathways
12.05 CXCL10 IFNG TNF
12 12.05 IFNG PTGS2 TNF
13
Show member pathways
12.03 F2 THBD VWF
14
Show member pathways
12.01 IFNG IL10 TNF
15 11.96 F2 THBD VWF
16 11.95 IFNG THBD TNF
17 11.95 CCL5 CXCL10 IFNG IL10 PTGS2 TNF
18
Show member pathways
11.89 CCL5 F2 IFNG PTGS2 TNF
19 11.86 IFNG IL10 TNF
20 11.85 IL10 PTGS2 TNF
21
Show member pathways
11.8 IFNG IL10 TNF
22 11.78 CXCL10 IFNG PTGS2 TNF
23 11.76 IFNG IL10 TNF
24 11.72 CCL5 IFNG TNF
25 11.66 IFNG IL10 TNF
26 11.66 CCL5 CXCL10 PTGS2 TNF
27
Show member pathways
11.62 IFNG PTGS2 TNF
28
Show member pathways
11.53 IFNG PTGS2 TNF
29 11.43 IFNG IL10 THBD TNF
30 11.4 IFNG IL10 TNF
31
Show member pathways
11.23 IFNG IL10 TNF
32 11.2 IFNG IL10 TNF
33 11.09 IFNG IL10
34 11.09 IFNG IL10 TNF
35 11.07 F2 IFNG
36 11.05 CCL5 TNF
37 11.04 CCL5 CXCL10 IL10 TNF
38 10.93 PTGS2 TNF
39 10.71 CCL5 CXCL10 IL10 PTGS2 TNF

GO Terms for Spotted Fever

Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL5 CXCL10 F2 HTRA1 IFNG IL10
2 extracellular space GO:0005615 9.23 CCL5 CXCL10 F2 HTRA1 IFNG IL10

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 CXCL10 F2 IFNG PTGS2
2 immune response GO:0006955 9.85 CCL5 CXCL10 IFNG IL10 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.82 F2 IFNG TNF
4 cellular response to lipopolysaccharide GO:0071222 9.79 CXCL10 IL10 TNF
5 response to organic substance GO:0010033 9.75 IL10 PTGS2 TNF
6 response to lipopolysaccharide GO:0032496 9.73 CXCL10 IL10 PTGS2 THBD
7 regulation of insulin secretion GO:0050796 9.72 CCL5 IFNG TNF
8 response to glucocorticoid GO:0051384 9.7 IL10 PTGS2 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.69 CCL5 PTGS2 TNF
10 positive regulation of cytokine secretion GO:0050715 9.68 IL10 TNF
11 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.68 CXCL10 F2
12 protein import into nucleus, translocation GO:0000060 9.67 IFNG TNF
13 response to tumor necrosis factor GO:0034612 9.67 CCL5 PTGS2
14 negative regulation of interleukin-6 production GO:0032715 9.66 IL10 TNF
15 positive regulation of protein complex assembly GO:0031334 9.66 IFNG TNF
16 negative regulation of myoblast differentiation GO:0045662 9.65 CXCL10 TNF
17 positive regulation of NF-kappaB import into nucleus GO:0042346 9.65 PTGS2 TNF
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.65 IL10 TNF
19 hemostasis GO:0007599 9.65 F2 THBD VWF
20 inflammatory response GO:0006954 9.65 CCL5 CXCL10 IL10 PTGS2 TNF
21 positive regulation of osteoclast differentiation GO:0045672 9.64 IFNG TNF
22 response to vitamin D GO:0033280 9.63 CXCL10 PTGS2
23 blood coagulation, intrinsic pathway GO:0007597 9.63 F2 VWF
24 positive regulation of monocyte chemotaxis GO:0090026 9.62 CCL5 CXCL10
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
27 positive regulation of T cell migration GO:2000406 9.6 CCL5 CXCL10
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL10 TNF
29 negative regulation of fibrinolysis GO:0051918 9.58 F2 THBD
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IFNG PTGS2 TNF
31 negative regulation of platelet activation GO:0010544 9.57 F2 THBD
32 endothelial cell apoptotic process GO:0072577 9.56 IL10 TNF
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.54 IL10 TNF
34 positive regulation of fever generation GO:0031622 9.49 PTGS2 TNF
35 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
37 response to virus GO:0009615 9.26 CCL5 CXCL10 IFNG TNF
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 IFNG TNF
39 regulation of receptor activity GO:0010469 9.1 CCL5 CXCL10 F2 IFNG IL10 TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 CXCL10 IFNG IL10 TNF

Sources for Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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