Squamous Cell Carcinoma malady

Wikipedia: Squamous cell carcinoma (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell. These...⁴⁴ more...

MalaCards: Squamous Cell Carcinoma, also known as squamous cell cancer, is related to carcinoma and prostatitis. An important gene associated with Squamous Cell Carcinoma is CTTN (cortactin), and among its related pathways are MAPK Family Pathway and Transendothelial Migration of Leukocytes. The drugs carmustine and diethylstilbestrol diphosphate and the compounds nmda and arginine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and spleen, and related mouse phenotypes are growth/size and tumorigenesis.

Disease Ontology: A carcinoma that derives from squamous epithelial cells.⁶

Aliases & Descriptions:

squamous cell carcinoma 6 7 8 43 squamous cell cancer 6 32 squamous cell carcinoma nos (morphologic abnormality) 6 squamous cell carcinoma (morphologic abnormality) 6 squamous cell carcinoma (disorder) 6 malignant squamous cell neoplasm 43

malignant squamous cell tumor 6 squamous cell epithelioma 6 carcinoma squamous cell 32 epidermoid carcinoma 6 squamous carcinoma 6 carcinoma 43

Diseases related to squamous cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1637)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	398.9	ZNF510, ZNF673, ZNF410, ZNF706, ZNF124, ZNF254
2	prostatitis	263.5	ZNF673, PIK3CA, PIK3C2B, PIK3C2A, PIK3CG, PIN1
3	esophagitis	261.3	ZNF673, ZNF410, ZNF639, PIK3CA, PIK3C2A, PIK3CG
4	adenocarcinoma	251.4	PIK3CA, PIK3C2A, PIK3CG, PIN1, PIM1, LRAT
5	leukemia	243.9	ZNF673, PIK3CA, PIK3C2A, PIK3CG, PIN1, PIM1
6	pancreatitis	239.2	PIK3CA, PIK3C2A, PIK3CG, PIN1, PI3, PIM1
7	hepatocellular carcinoma	221.4	PIK3CA, PIK3CG, PIN1, KLF6, NCAM1, NCOA3
8	melanoma	217.8	PIK3CA, PIK3C2A, PIK3CG, PI3, PIM1, LRAT
9	neuronitis	217.0	PIK3CA, PIK3C2B, PIK3C2A, PIK3CG, PIN1, PIM1
10	gastric cancer	214.8	PIK3CA, PIK3CG, PIN1, PIM1, LRP1B, KLF4
11	cervicitis	214.6	PIK3CA, PIK3CG, PIN1, LRIG1, RFC1, PDCD1
12	oral squamous cell carcinoma	206.5	ZNF510, PIK3CA, PIDD, PIK3C2A, PIN1, PIM1
13	esophageal squamous cell carcinoma	204.4	ZNF673, ZNF410, ZNF639, PIK3CA, PIN1, PIM1
14	thyroiditis	201.5	PIGF, PIK3CA, PIK3C2A, PIK3CG, PIN1, LRP1B
15	colon cancer	189.4	PIK3CA, PIDD, PIK3CG, KLF4, KLF6, RFC1
16	breast carcinoma	187.9	PIK3CA, PIK3CG, PI3, NCOA3, NCOR1, RECK
17	hypoxia	168.2	PIGF, PIK3CA, PIK3C2A, PIK3CG, PIM1, NCOA1
18	ovarian carcinoma	163.9	PIGF, PIK3CA, PIK3CG, PI3, NCOA3, PDCD4
19	neuroblastoma	161.1	PIK3CA, PIK3CG, PIN1, KLF4, KLF6, NCAM1
20	adenoma	160.2	ZNF410, PIK3CA, KLF4, NCAM1, NCOA1, NCOA3
21	sarcoma	158.8	PIK3CA, PIK3C2B, PIK3C2A, PIK3CG, NCAM1, NCOA1
22	cervical cancer	157.3	PIK3CA, PIK3CG, PIN1, LRIG1, RFC1, PDCD1
23	arthritis	155.3	PIK3CG, PIN1, RFC1, PDCD1, PDCD1LG2, RECK
24	rheumatoid arthritis	145.7	PIK3CG, PIN1, RFC1, PDCD1, PDCD1LG2, RECK
25	lung carcinoma	144.5	PIK3CA, PIK3CG, LRP1B, KLF6, NCAM1, RECK
26	myeloid leukemia	143.0	ZNF673, PIK3CA, PIK3C2A, PIK3CG, PIN1, PIM1
27	fibrosis	142.6	PIK3CA, PIK3CG, PIN1, PI3, KLF6, NCOA3
28	colon carcinoma	141.7	PIK3CA, PIK3CG, KLF4, NCAM1, PDCD4, KIT
29	myeloma	137.6	PIK3CA, PIK3CG, NCAM1, RECK, RELA, KIT
30	laryngitis	136.1	ZNF706, PIK3CA, PIM1, PDCD4, RECQL4, RELA
31	alzheimer's disease	133.5	PIK3CA, PIK3CG, PIN1, LRP1B, LRAT, KLF6
32	osteosarcoma	125.1	PIK3CA, PIK3CG, RFC1, NCOA1, PDE3A, PDE3B
33	nasopharyngitis	124.5	PIK3CA, PIK3CG, KLF6, NCOA3, PDCD1, RECK
34	cholesterol	124.1	PIK3CA, PIK3C2B, PIK3C2A, PIK3CG, LRP1B, LRAT
35	lymphocytic leukemia	123.3	PIK3CA, PIK3CG, NCAM1, PDCD1LG2, PDE3B, RECK
36	retinitis	123.2	PIGF, PIK3CA, PIK3C2A, PIK3CG, PIM1, LRAT
37	esophageal cancer	121.3	PIK3CA, PIK3CG, KLF4, PDCD1LG2, PDCD4, SFRP1
38	astrocytoma	120.7	PIK3CA, PIK3CG, KLF6, NCAM1, PDE3B, RECK
39	multiple myeloma	119.6	PIK3CA, PIK3CG, NCAM1, RECK, RELA, KIT
40	endometrial carcinoma	117.6	PIK3CA, PIK3C2A, PIK3CG, NCOA1, NCOA3, NCOR1
41	cervical carcinoma	117.0	PIK3CA, PIK3CG, PDCD1, PDCD1LG2, RECK, RECQL4
42	cerebritis	116.4	PIGF, PIK3C2A, PIK3CG, KLF4, KLF6, NCAM1
43	thyroid carcinoma	116.2	PIK3CA, PIK3CG, PI3, RECQL4, SFN, PCNA
44	acute myeloid leukemia	110.7	ZNF673, PIK3CA, PIK3C2A, PIK3CG, PIN1, PIM1
45	epithelial ovarian cancer	110.7	PIK3CA, PIK3CG, NCOA1, NCOA3, NCOR1, RELA
46	asthma	110.0	PIK3CA, PIK3CG, PIN1, PDCD1, PDE3B, RECK
47	peritonitis	109.7	PIK3C2A, PDE3B, RELA, KIT, VTN, SFRP2
48	retinoblastoma	109.3	PIK3CA, PIK3CG, KLF6, RFC1, RFC5, NCAM1
49	endometrial cancer	109.2	PIK3CA, PIK3CG, NCOA1, NCOA3, PDCD4, SFN
50	ischemia	108.3	PIGF, PIK3CA, PIK3C2A, PIK3CG, KLF4, NCAM1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bleomycin, bleomycin sulfate, carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to squamous cell carcinoma:

²²

MGI Mouse Phenotypes related to squamous cell carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	PIK3CA, PIK3C2A, PIK3CG, PIN1, PIM1, KLF6
2	tumorigenesis	MP:0002006	INF	PIK3CA, LRIG1, KLF4, NCOA3, PDCD1LG2, PDCD4
3	hematopoietic system phenotype	MP:0005397	INF	PIM1, KLF6, PDCD1, PDCD1LG2, RECQL4, KIT
4	nervous system phenotype	MP:0003631	INF	LRIG1, LRAT, NCOA1, NCOR1, PDCD1, RECK
5	endocrine/exocrine gland phenotype	MP:0005379	INF	LRIG1, KLF4, NCOA1, PDCD4, KISS1, KISS1R
6	normal phenotype	MP:0002873	56.8	PIDD, LRIG1, LRP1B, KLF4, PDE3A, RELA
7	skeleton phenotype	MP:0005390	52.1	PIK3CG, NCOA1, RECK, RELA, KIT, SFN
8	embryogenesis phenotype	MP:0005380	50.7	PIK3CA, KLF6, NCOA1, NCOA3, NCOR1, RECK
9	limbs/digits/tail phenotype	MP:0005371	37.6	LRIG1, RECK, RECQL4, RELA, KIT, SFN
10	no phenotypic analysis	MP:0003012	35.4	PIK3C2B, PDCD1LG2, KIF22, SFRP1, SFRP2, PCNA
11	adipose tissue phenotype	MP:0005375	29.7	PIK3CA, PIK3C2A, NCOA3, NCOR1, PDE3B, RETN
12	pigmentation phenotype	MP:0001186	23.3	PDE3B, RECQL4, KIT, RB1, RBP1, SERPINF1
13	respiratory system phenotype	MP:0005388	10.9	TP63
14	integument phenotype	MP:0010771	INF	PIK3C2B, PIK3CG, PIN1, LRIG1, KLF4, KLF6
15	cellular phenotype	MP:0005384	INF	PIK3CA, PIK3CG, PIN1, PIM1, LRIG1, KLF4
16	liver/biliary system phenotype	MP:0005370	INF	KLF6, NCOA3, NCOR1, RECK, RETN, WASF2
17	mortality/aging	MP:0010768	INF	PIK3CA, PIK3C2A, KLF4, KLF6, NCAM1, NCOR1
18	immune system phenotype	MP:0005387	INF	NCOA1, NCOA3, NCOR1, PDCD4, RECQL4, SGCB
19	reproductive system phenotype	MP:0005389	INF	PIK3CA, LRAT, KLF4, KLF6, NCOA1, NCOA3
20	vision/eye phenotype	MP:0005391	INF	PIK3CA, PIN1, LRAT, NCAM1, PDCD1, RECQL4
21	craniofacial phenotype	MP:0005382	INF	LRIG1, KLF4, NCOA3, RECQL4, RERE, KIT
22	renal/urinary system phenotype	MP:0005367	INF	NCOA1, NCOA3, PDCD1, PDCD4, KIT, KISS1
23	cardiovascular system phenotype	MP:0005385	INF	PIK3CA, PIK3CG, KLF6, PDCD1, RECK, RELA
24	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, KLF4, NCAM1, NCOA1, NCOA3, NCOR1
25	digestive/alimentary phenotype	MP:0005381	INF	LRIG1, KLF4, NCOA3, RECQL4, KIT, KISS1
26	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CA, PIK3C2A, PIK3CG, LRAT, KLF4, NCOA1
27	hearing/vestibular/ear phenotype	MP:0005377	INF	NCOA3, KIT, SFN, RB1, RBP1, VDR
28	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3CG, NCOA3, NCOR1, PDCD1, RELA
29	other phenotype	MP:0005395	INF	RECK, SERPINH1, RARG, RARA, RARB, CLU

Articles related to squamous cell carcinoma:

(show top 50)    (show all 4779)

id	Title	Authors	Year	Affiliating Genes
1	Clinical significance of GPR56, transglutaminase 2, a nd NF-I_B in esophageal squamous cell carcinoma. (20874003)	Kausar T.... Ralhan R.	2011	TGM2, GPR56
2	Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluo rouracil-induced apoptosis. (21522149)	Wood J.... Hague A.	2011	BAG1, HSPA4
3	Prognostic significance of Oct4 and Sox2 expression i n hypopharyngeal squamous cell carcinoma. (20937145)	Ge N.... Kang T.	2010	POU5F1, SOX2
4	BRAF and RKIP are significantly decreased in cutaneous squamous cell carcinoma. (19342899)	Zaravinos A.... Spandidos D.A.	2009	BRAF, PEBP1
5	Detection of human papilloma virus subtypes 16 and P1 6(ink4a) in invasive squamous cell carcinoma of the fallopian tube and concomit ant squamous cell carcinoma in situ of the cervix. (19708185)	Wang Z.... Qiu S.	2009	CDKN2A
6	Usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung. (19369633)	Wang C.W.... Chen T.C.	2009	CDKN2A
7	Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study. (18429959)	Yokoyama A.... Maruyama K.	2008	ALDH2
8	Aberrant promoter methylation of the TPEF gene in esophageal squamous cell carcinoma. (19040536)	Zhao B.J.... Ma X.	2008	TMEFF2
9	Dipeptidyl peptidase IV expression in cancer and stromal cells of human esophageal squamous cell carcinomas, adenocarcinomas and squamous cell carcinoma cell lines. (19024603)	Goscinski M.A.... Giercksky K.E.	2008	DPP4
10	Expression of cell cycle associated proteins influences radiocurability of T2N0 squamous cell carcinoma of the larynx. (18329328)	Rafferty M.... Jones A.S.	2008	EGFR, CCND1
11	Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy. (18497852)	Hsu K.F.... Shiau A.L.	2008	SERPINB4
12	A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. (17504990)	Vachani A.... Showe L.C.	2007	MMP1, KLK10
13	Expression pattern of squamous cell carcinoma antigen in oesophageal dysplasia and squamous cell carcinoma. (17523076)	Parenti A.... De Caro R.	2007	SERPINB3
14	Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. (17614107)	Li C.... Wei Q.	2007	PARP1, APEX1, XRCC1
15	The involvement of hypoxia-inducible factor-1alpha in the susceptibility to gamma-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells. (17066447)	Sasabe E.... Osaki T.	2007	HMOX1, SOD2, HIF1A
16	E-cadherin increases squamous cell carcinoma antigen expression through phosphatidylinositol-3 kinase-Akt pathway in squamous cell carcinoma cell lines. (17549365)	Nakagawa T.... Sugino N.	2007	CDH1, SERPINB3, SERPINB4
17	Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma. (17143482)	Park S.Y.... Choi S.W.	2007	GRM5
18	Studies of the serum HER-2/neu and squamous cell carcinoma-related antigen expression in patients with oral squamous cell carcinoma. (17238969)	Chen C.H.... Tsai C.C.	2007	ERBB2, SERPINB3
19	Squamous cell carcinoma-antigen messenger RNA level in peripheral blood predicts recurrence after resection in patients with esophageal squamous cell carcinoma. (16701102)	Honma H.... Hatakeyama K.	2006	SERPINB3
20	p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. (16776716)	Dotto J.E.... Glusac E.J.	2006	TP63
21	Inactivation of Crk SH3 domain-binding guanine nucleotide-releasing factor (C3G) in cervical squamous cell carcinoma. (16681758)	Okino K.... Takeshita T.	2006	RAP1A, RAPGEF1
22	Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer. (17131471)	Jazii F.R.... Salekdeh G.H.	2006	HSPA8, CALR, ANXA1
23	Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. (17018598)	Sarkaria I.... Singh B.	2006	GLI1, DCUN1D1
24	Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. (15583802)	Suzuki F.... Fukuda S.	2005	MIF
25	Maspin expression in CIN 3, microinvasive squamous cell carcinoma, and invasive squamous cell carcinoma of the uterine cervix. (15731774)	Xu C.... Lawrence W.D.	2005	SERPINB5
26	Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines. (16211231)	Sueoka K.... Sugino N.	2005	MMP9, SERPINB3, SERPINB4
27	Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. (15257310)	Nilsson K.... Landberg G.	2004	RB1, CDKN2A
28	Identification of a minimal deletion region on chromosome 5q in Chinese esophageal squamous cell carcinomas. (15488641)	Li X.D.... Wang M.R.	2004	APC
29	Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. (14719077)	Hirakawa H.... Sugino N.	2004	SERPINB3
30	Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. (12773976)	Shimada H.... Ochiai T.	2003	SERPINB3
31	Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. (12949054)	Yokoyama A.... Ishii H.	2003	ADH1B
32	The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. (12796399)	Estilo C.L.... Singh B.	2003	PIK3CA, DCUN1D1
33	Clinicopathological significance of pRb2/p130 expression in squamous cell carcinoma of the esophagus. (12474056)	Nozoe T.... Maehara Y.	2002	RBL2
34	TP53 codon 72 polymorphism in oral squamous cell carcinoma. (12530090)	Drummond S.N.... Gomez R.S.	2002	TP53
35	Clinical significance of combined use of macrophage colony-stimulating factor and squamous cell carcinoma antigen as a selective diagnostic marker for squamous cell carcinoma arising in mature cystic teratoma of the ovary. (10831350)	Suzuki M.... Sato I.	2000	CSF1
36	Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. (10653592)	Cataltepe S.... Upton M.P.	2000	CMA1, CTSL1, CTSG
37	Prognosis in bronchogenic squamous cell carcinoma groups divided according to serum squamous cell carcinoma-related antigen and cytokeratin 19 fragment levels. (10727677)	Kashiwabara K.... Esaki T.	2000	KRT19
38	The nm23-H1 gene as a predictor of sensitivity to chemotherapeutic agents in oesophageal squamous cell carcinoma. (10507772)	Iizuka N.... Oka M.	1999	NME1
39	Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. (10506755)	Ondrey F.G.... Van Waes C.	1999	JUN, IL8, CSF2
40	Immunohistochemical and molecular analysis of bax, bcl-2 and p53 genes in laryngeal squamous cell carcinomas. (10368653)	Fracchiolla N.S.... Broich G.	1999	TP53, BCL2, BAX
41	Evaluation of Tomudex in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group study. (10360608)	Samlowski W.E.... Ensley J.F.	1998-1999	TYMS
42	Significance of p53 protein expression in growth pattern of esophageal squamous cell carcinoma. (9683820)	Nozoe T.... Sugimachi K.	1998	TP53
43	5-Fluorouracil dose intensification and granulocyte-m acrophage colony-stimulating factor in cisplatin-based chemotherapy for relapse d squamous cell carcinoma of the head and neck: a phase II study. (9626807)	Merlano M.... Rosso M.	1998	CSF2
44	A subcloned human esophageal squamous cell carcinoma cell line with low thrombomodulin expression showed increased invasiveness compared with a high thrombomodulin-expressing clone--thrombomodulin as a possible candidate for an adhesion molecule of squamous cell carcinoma. (9619877)	Matsushita Y.... Sato E.	1998	THBD
45	Immunohistochemical studies of vascular volume and proliferative activity in squamous cell carcinoma of the esophagus. (9017984)	Koide N.... Nagata T.	1997	PCNA
46	Prognostic significance of pretreatment squamous cell carcinoma antigen and carcinoembryonic antigen in squamous cell carcinoma of the uterine cervix. (9062143)	Bae S.N.... Kim S.J.	1997	CEACAM5
47	FHIT gene alterations in head and neck squamous cell carcinomas. (8790406)	Virgilio L.... Croce C.M.	1996	FHIT
48	Alterations in EGF-dependent proliferative and phosph orylation events in squamous cell carcinoma cell lines by a tyrosine kinase inh ibitor. (7916899)	Brunton V.G.... Workman P.	1994	EGF
49	Squamous cell carcinomas, an immunohistochemical and ultrastructural study. (1284199)	Suo Z.... Nesland J.M.	1992	KRT6B
50	Lipid-associated sialic acid, squamous cell carcinoma antigen, carcinoembryonic antigen, and lactic dehydrogenase levels as tumor markers in squamous cell carcinoma of the head and neck. (1423179)	Dreyfuss A.I.... Andersen J.W.	1992	CEACAM3

Genes related to squamous cell carcinoma according to GeneCards:

(show top 50)    (show all 1673)

id	Symbol	Description	Score	GeneCards Section Context
1	CTTN	cortactin	11.1	Publications, Aliases & Descriptions, Summaries
2	KDM4C	lysine (K)-specific demethylase 4C	11.1	Expressions, Publications, Aliases & Descriptions, Summaries
3	TP63	tumor protein p63	11.1	Expressions, Publications, Aliases & Descriptions
4	SART1	squamous cell carcinoma antigen recognized by T cells	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs
5	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	11.1	Publications, Aliases & Descriptions
6	SART3	squamous cell carcinoma antigen recognized by T cells 3	11.1	Transcripts, Aliases & Descriptions, Orthologs
7	DEC1	deleted in esophageal cancer 1	11.1	Summaries, Publications
8	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.1	Publications, Aliases & Descriptions
9	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.1	Publications, Summaries
10	C15orf48	chromosome 15 open reading frame 48	11.1	Publications, Expressions, Summaries
11	GPR87	G protein-coupled receptor 87	11.1	Expressions, Publications, Summaries
12	RNF6	ring finger protein (C3H2C3 type) 6	11.1	Publications, Summaries
13	PTCH1	patched 1	11.1	Publications, Summaries
14	DSE	dermatan sulfate epimerase	11.1	Expressions, Publications, Aliases & Descriptions, Orthologs
15	CTAG1B	cancer/testis antigen 1B	11.1	Publications, Aliases & Descriptions
16	DND1	dead end homolog 1 (zebrafish)	11.1	Publications, Summaries
17	TMC6	transmembrane channel-like 6	11.1	Publications, Summaries
18	TMC8	transmembrane channel-like 8	11.1	Publications, Summaries
19	MSLN	mesothelin	11.1	Expressions, Publications, Summaries
20	DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	11.1	Publications, Expressions, Aliases & Descriptions
21	ZNF639	zinc finger protein 639	11.1	Publications, Aliases & Descriptions
22	TP53	tumor protein p53	11.0	Publications, Functions
23	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
24	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
25	EGFR	epidermal growth factor receptor	11.0	Publications
26	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
27	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
28	CCND1	cyclin D1	11.0	Publications, Functions
29	PCNA	proliferating cell nuclear antigen	11.0	Publications
30	BAX	BCL2-associated X protein	11.0	Publications
31	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
32	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
33	EGF	epidermal growth factor	11.0	Publications
34	TYMP	thymidine phosphorylase	11.0	Publications
35	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications, Functions
36	PTEN	phosphatase and tensin homolog	11.0	Publications, Functions
37	FHIT	fragile histidine triad	11.0	Publications
38	PDPN	podoplanin	11.0	Expressions, Publications
39	KRT14	keratin 14	11.0	Publications
40	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
41	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
42	CCNA2	cyclin A2	11.0	Publications
43	CTSD	cathepsin D	11.0	Publications
44	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
45	VEGFC	vascular endothelial growth factor C	11.0	Publications
46	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
47	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
48	GSTM1	glutathione S-transferase mu 1	11.0	Publications
49	GSTP1	glutathione S-transferase pi 1	11.0	Publications, Functions
50	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications

Pathways related to squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 333)

id	Pathway	Score	Top Affiliating Genes
1	MAPK Family Pathway36	28.4	BRAF, VEGFB, VEGFC, BMP2, BMP4, BMP6
2	Transendothelial Migration of Leukocytes36	26.5	VCAM1, VAV2, RAP1A, RAP1B, RAC1, CLDN4
3	Cellular Apoptosis Pathway36	25.5	KIT, VEGFB, VEGFC, VDAC1, BMP2, BMP4
4	Cell Cycle / Checkpoint Control3	25.0	PIN1, RECQL4, VRK1, PCNA, BUB1B, RB1
5	Focal adhesion20	24.8	PIK3CA, PIK3CG, VTN, BRAF, VEGFB, VEGFC
6	Rac1 Pathway36	23.4	VEGFB, BMP4, BMP6, BMP7, RAF1, RAC1
7	JNK Pathway36	22.9	KIT, VEGFB, BMP2, BMP4, BMP6, BMP7
8	PPAR Pathway36	21.1	NCOA1, KIT, VEGFB, VEGFC, BMP2, BMP4
9	Integrin Pathway36	20.3	BRAF, VCL, VAV2, MYC, RAF1, RAC1
10	IL-6 Pathway36	20.0	PIM1, BRAF, BMP2, BMP4, BMP6, BMP7
11	Tuberculosis20	19.9	RELA, VDR, MYD88, RAF1, BCL10, BCL2
12	Endocytosis20	19.8	KIT, RAB11A, ZFYVE9, PARD3, KDR, CDC42
13	FAK1 Signaling36	19.7	BRAF, VCL, RAF1, RAC1, PAK1, PAK4
14	WNT Signaling36	19.6	BTRC, VIM, MYC, RAC1, BIRC5, CLDN1
15	Cytoskeletal Signaling3	18.6	WASF2, VIM, VDAC1, VCL, VCP, LMNA
16	Osteoclast differentiation20	17.8	PIK3CA, PIK3CG, RELA, RAC1, CHUK, LCK
17	Calpain Protease Regulates Cellular Mechanics36	17.5	RB1, VCL, CDK6, CDK2, CDKN1B, CDK4
18	Toll-like receptor signaling pathway20	17.3	PIK3CA, PIK3CG, RELA, MYD88, RAC1, CHUK
19	Development_EGFR signaling pathway41	16.7	PIK3CA, MYC, RAF1, RAC1, PAK1, CHUK
20	Adherens junction20	16.7	WASF2, VCL, RAC1, PARD3, YES1, CDC42
21	TRKA Signaling36	15.9	BRAF, MYC, RAP1A, RAF1, RAP1B, RAC1
22	PI3K Signaling in B-Lymphocyte36	15.8	PIK3C2B, PIK3C2A, RAF1, RAC1, BCL10, CHUK
23	TREM1 Pathway36	15.4	BRAF, MYD88, RAF1, CHUK, BAD, BAX
24	Renal cell carcinoma20	15.4	VHL, RAP1A, RAF1, RAP1B, RAC1, RAPGEF1
25	Ceramide Pathway36	15.3	RAF1, BAD, ATF3, ATF2, JUN, JUND
26	G-AlphaQ Signaling36	15.3	BRAF, RAF1, CHUK, ARHGEF12, ARHGEF7, ARHGEF11
27	CD28 Signaling in T-Helper Cell36	15.2	PIK3C2B, PIK3C2A, RAC1, PAK1, BCL10, ZAP70
28	Immune response_IFN gamma signaling pathway41	15.2	PIK3CA, MYC, RAP1A, RAPGEF1, CEBPB, ATF2
29	Immune response_IL-1 signaling pathway41	15.0	RELA, SERPINE1, MYD88, CHUK, UBC, ATF2
30	FGF Pathway36	14.9	RAF1, RALA, RAC1, ATF2, CDC42, FGF1
31	Inhibition of Matrix Metalloproteinases36	14.9	RECK, SDC2, MMP1, MMP10, MMP11, MMP12
32	Apoptosis and survival FAS signaling cascades10	14.9	LMNA, LMNB1, BMF, BIRC2, PARP1, BCL2
33	Apoptosis and survival_FAS signaling cascades41	14.7	LMNA, LMNB1, BMF, BIRC2, PARP1, BCL2
34	Development_Neurotrophin family signaling41	14.7	PIK3CA, BRAF, RAP1A, RAF1, RAC1, RAPGEF1
35	Cell cycle_Regulation of G1/S transition (part 2)41	14.7	RELA, RB1, RBL2, RBL1, CHUK, JUN
36	Development_FGFR signaling pathway41	14.6	PIK3CA, RAF1, RAC1, PAK1, SDC1, SDC2
37	Immune response_Oncostatin M signaling via MAPK in human cells41	14.6	RAF1, RAC1, CEBPB, ATF2, JUN, JUND
38	LPS Stimulated MAPK Signaling36	14.5	RAF1, RAC1, PAK1, CHUK, ATF2, JUN
39	Cytoskeleton remodeling FAK signaling10	14.3	RAP1A, RAF1, RAPGEF1, PAK1, KDR, CDC42
40	Immune response_MIF in innate immunity response41	14.2	RELA, MYD88, CHUK, CEBPB, JUN, IRAK4
41	Colorectal cancer20	14.1	PIK3CG, BRAF, RAC1, BAD, AXIN1, MSH2
42	Signal transduction_PTEN pathway41	12.1	PCNA, ITGA5, ITGB1, IGF1R, CASP9, TSC2
43	Translation Regulation activity of EIF4F10	11.9	PAK1, MAP2K3, MAPK12, AKT2, AKT3, EIF4G1
44	Pancreatic cancer20	11.6	BRCA2, RALA, CDK6, AKT2, AKT3
45	Endothelin-1 Signaling Pathway36	INF	KIT, BRAF, MYC, BMP2, BMP4, BMP6
46	JAK-STAT Pathway36	INF	KIT, VEGFB, VEGFC, MYC, BMP2, BMP4
47	Actin Nucleation by ARP-WASP Complex36	INF	KIT, RAC1, KDR, AXL, CDC42, ITGA2
48	Nanog in Mammalian ESC Pluripotency36	INF	KIT, NANOG, BRAF, VEGFB, VEGFC, BMP2
49	MAPK Signaling36	INF	KIT, BRAF, VEGFB, VEGFC, VCL, MYC
50	ERK Signaling36	INF	KIT, BRAF, BRF1, VEGFB, VEGFC, MYC

Compounds related to squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 443)

id	Compound	Score	Top Affiliating Genes
1	nmda32 42	INF	PIK3CA, NCAM1, SGCB, KISS1R, VIM, RAP1A
2	arginine32	INF	PIK3CA, PIK3C2A, RFC1, NCOA3, RECK, SGCB
3	serine32	INF	PIK3CA, PIK3CG, PIN1, PI3, PIM1, KLF6
4	vegf32	69.5	PIGF, PIK3CA, PIK3C2A, PIK3CG, NCAM1, RECK
5	estrogen32	60.9	ZNF673, KLF6, NCOA1, NCOA3, NCOR1, RETN
6	actinomycin d32	44.6	PIK3CA, PIK3CG, RETN, KIT, SFTPB, RB1
7	lactate32	39.8	PIK3CA, PIK3C2A, NCAM1, RECK, KIT, VTN
8	butyrate32	38.7	KLF4, NCOA1, NCOA3, PCNA, RB1, SETD2
9	5fluorouracil32	38.6	PIK3CA, PIK3CG, KIT, PCNA, RB1, RBL1
10	creatinine32	34.6	NCAM1, RETN, PCNA, RBP4, SELE, VDAC1
11	etoposide32 42 9 9	36.8	PIK3CA, PIK3CG, RECK, PCNA, RB1, SELE
12	vitamin d32	32.5	NCOA1, NCOA3, NCOR1, SERPINE1, VIM, VDR
13	ly29400232	29.8	PIK3CA, PIK3C2A, PIK3CG, PI3, RETN, VTN
14	ascorbic acid32 18	27.5	PIK3CG, SGCB, SFTPB, PCNA, RBP4, SETD2
15	quercetin32 42 9 18 9	28.8	PIK3CA, PIK3C2B, PIK3C2A, PIK3CG, PIM1, SELE
16	cytochalasin d32 42	24.4	PIK3CG, VTN, SELE, VIM, VCAM1, VCL
17	h2o232	22.9	PIK3CG, RECQL4, SGCB, SERPINB2, BRCA2, VDAC1
18	nacl32	21.5	SGCB, SFTPB, VDAC1, VCAN, BMP7, RAD51
19	phospholipid32	21.3	SFTPB, PCTP, RBP4, RBP1, LPAR3, VDAC1
20	ag 147832	21.1	PIK3CA, PIK3CG, SERPINE1, RAF1, MUC5AC, BAK1
21	gdp32	19.6	VIM, LMNA, RAP1A, RAD51, RAF1, RALA
22	thalidomide32 42 9 9	22.6	VTN, VEGFA, BIRC2, BIRC3, BIRC5, KDR
23	phosphatidylcholine32	19.3	LRAT, SFTPB, PCTP, SELE, VIM, VDAC1
24	hydroxyurea32 9 9	21.2	RECQL4, KIT, PCNA, NBN, BRCA2, VCAM1
25	carbon32	18.9	VTN, PCNA, VDR, BLVRB, BCHE, UCP1
26	oxaliplatin32 34 9 9	21.8	VEGFA, BIRC5, BCL2L1, MTHFR, XRCC1, XPA
27	depsipeptide32	17.8	RB1, SERPINB5, BRAF, MYC, RAF1, PAK1
28	silymarin32	17.1	PCNA, VEGFA, BMP6, BIRC5, PARP1, CHUK
29	rottlerin32 42	17.9	PIK3CG, VCAM1, RAC1, PARP1, XIAP, JUN
30	neomycin32	16.9	VIM, BMP2, CEACAM5, CDKN2A, GUSB, FGF4
31	indole-3-carbinol32	16.6	BRCA2, BIRC5, PARP1, BCL2, BCL2L1, BAX
32	copper32 18	17.5	SFTPB, RBP4, BLZF1, LGALS1, MT1G, MT-CO1
33	verapamil32 34 9 18 9	20.5	RECK, MYC, MVP, JAK2, CDH1, GSTP1
34	benzo(a)pyrene32	16.4	RB1, NAT2, RARB, XRCC1, XPA, XPC
35	leukotriene b432 42 18	18.2	RAC1, LCN2, MPO, ITGAL, MMP9, GUSB
36	tetrapeptide32	15.7	PIN1, VTN, RB1, BIRC5, BCL2L1, LCK
37	leucovorin32 34 9 9	18.4	VEGFA, UMPS, CGB, CGB5, CEACAM5, CEACAM3
38	sialic acid32	15.4	NCAM1, RECK, RBP4, SERPINF2, CLU, PAEP
39	tarc32	15.2	CD4, CDH1, ITGA4, IL10, IL13, IL18
40	fluvastatin32 34 9 9	17.9	PIK3C2A, SERPINE1, VCAM1, BMP2, RAC1, CHKB
41	sodium orthovanadate32	14.9	SETD2, VCL, RAF1, BLZF1, JAK2, CDC25C
42	rotenone32	14.8	PIK3CG, PARP1, PARK7, BCL2, BCL2L1, UCP1
43	clozapine32 34 9 9	17.8	LEP, CHKB, MPO, FOS, GRIN2B, IL10
44	olomoucine32 42 9 9	17.5	PCNA, RB1, KHDRBS1, BCL2, BAX, CDKN1A
45	phenylalanine32	14.4	BLZF1, CIITA, ZAP70, LCK, LBR, LAT
46	ribonucleic acid32	INF	KLF6, KIT, SFTPB, RBP4, SERPINB2, VEGFC
47	magnesium32 9 18 9	INF	PIK3C2B, PIK3C2A, RBP4, RAD51, RAC1, PAK1
48	hydrogen32 18	INF	PIN1, PIM1, SGCB, SFTPB, RBP1, SERPINB2
49	vitamin-e32	INF	PIK3C2A, RBP4, SERPINB2, VCAM1, RARA, BIRC2
50	isoproterenol32 9 9	INF	PDE3A, PDE3B, VIM, BRAF, LPAR3, MYBPC1

Cellular components related to squamous cell carcinoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	INF	LRP12, SGCB, LPAR3, CLCA4, CLDN4, CLDN1
2	nucleus	GO:005634	INF	ZNF510, ZNF410, ZNF124, ZNF254, ZNF639, PIK3C2B
3	cytosol	GO:005829	INF	PIK3CA, PIK3C2B, PIK3C2A, PIK3CG, PDCD4, PDE3A
4	extracellular region	GO:005576	45.9	NCAM1, PDCD1LG2, RETN, KISS1, VTN, SERPINE2
5	nucleoplasm	GO:005654	42.4	PIN1, RFC1, RFC5, NCOA1, NCOA3, NCOR1
6	cell surface	GO:009986	25.8	NCAM1, KISS1R, SFRP1, VEGFA, VCAM1, BMP2
7	external side of plasma membrane	GO:009897	19.6	NCAM1, KIT, VCAM1, KDR, B2M, CD28
8	extracellular matrix	GO:031012	17.8	VTN, SFRP1, SFRP2, SERPINE2, SERPINF1, SERPINE1
9	membrane raft	GO:045121	16.4	SELE, BSG, BCL10, LCK, LAT, FURIN
10	nucleolus	GO:005730	INF	NCOA3, PDCD4, RERE, VRK1, PCNA, RBL2
11	plasma membrane	GO:005886	INF	PIK3C2B, PIK3C2A, PIK3CG, PIM1, NCAM1, PDCD1
12	extracellular space	GO:005615	INF	KIT, VTN, SFN, SFRP1, SFRP2, SFRP5
13	cytoplasm	GO:005737	INF	PIDD, PIK3C2A, PIK3CG, PIN1, PIM1, KLF6
14	transcription factor complex	GO:005667	INF	KLF4, RELA, RBL2, LMO4, RARG, CLOCK

Biological processes related to squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 81)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphorylation	GO:006468	INF	PIM1, VRK1, BRAF, RARA, RAF1, BIRC5
2	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	ZNF254, KLF4, NCOR1, VHL, VDR, MYC
3	signal transduction	GO:007165	39.2	PIDD, LRP12, PDCD1, KIT, SFN, SFRP5
4	apoptotic process	GO:006915	37.7	PIDD, PIM1, PDCD1, PDCD4, SFN, SFRP5
5	positive regulation of cell proliferation	GO:008284	28.9	KIT, SFRP1, SFRP2, NBN, VEGFA, VEGFC
6	blood coagulation	GO:007596	27.9	PIK3CA, PIK3CG, PDE3A, PDE3B, KIF15, KIF22
7	cell proliferation	GO:008283	25.8	PIM1, KIF15, SFN, PCNA, BUB1B, NBN
8	response to drug	GO:042493	25.4	PDE3A, SFRP1, SFRP2, NBN, VEGFC, MYC
9	cell adhesion	GO:007155	24.8	NCAM1, VTN, VCAM1, VCAN, VCL, MYBPC1
10	virus-host interaction	GO:019048	24.3	RELA, BTRC, RB1, RBL1, VIM, VDAC1
11	negative regulation of transcription, DNA-dependent	GO:045892	24.3	ZNF639, KLF4, PDCD4, RELA, SFRP1, SFRP2
12	inflammatory response	GO:006954	23.4	PIK3CG, RELA, KIT, SELE, MYD88, BMP2
13	anti-apoptosis	GO:006916	23.0	PIK3CA, RELA, SERPINB2, BRAF, VHL, VEGFB
14	innate immune response	GO:045087	21.9	PIK3CG, PIN1, RELA, MYD88, CLU, BCL10
15	positive regulation of apoptotic process	GO:043065	20.9	NCOA1, SFRP1, SFRP2, BMP2, BMP4, RARG
16	response to hypoxia	GO:001666	20.6	SFTPB, VEGFA, VCAM1, BMP2, RAF1, LIMD1
17	platelet activation	GO:030168	20.3	PIK3CA, PIK3CG, SERPINF2, SERPINE1, VEGFA, VEGFB
18	induction of apoptosis	GO:006917	19.8	ZMAT3, BCL10, BCL2L11, LCK, BAD, BAX
19	cell-cell signaling	GO:007267	19.5	SFRP2, BMP2, S100A9, CGB, CD86, CD80
20	nerve growth factor receptor signaling pathway	GO:048011	19.1	PIK3CA, RELA, BRAF, VAV2, MYD88, RAP1A
21	positive regulation of cell migration	GO:030335	19.0	VEGFA, BMP2, KDR, FURIN, JAK2, CDH13
22	cell surface receptor signaling pathway	GO:007166	18.6	BSG, MYD88, BIRC2, BIRC3, KHDRBS1, BDKRB2
23	epidermal growth factor receptor signaling pathway	GO:007173	17.6	PIK3CA, PIK3C2A, RAF1, CHUK, UBC, BAD
24	response to organic cyclic compound	GO:014070	17.5	SFRP1, BMP4, BAK1, MSH2, JUN, CDKN1A
25	transforming growth factor beta receptor signaling pathway	GO:007179	17.4	NCOR1, RBL1, SERPINE1, MYC, ZFYVE9, PARP1
26	heart development	GO:007507	17.2	PCNA, RBP4, VCAM1, VCAN, BMP2, RAF1
27	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	16.9	RELA, MYD88, BIRC2, BIRC3, BCL10, LGALS1
28	platelet degranulation	GO:002576	16.8	SERPINF2, SERPINE1, VEGFA, VEGFB, VEGFC, VCL
29	insulin receptor signaling pathway	GO:008286	16.8	PIK3CA, PIK3C2A, PDE3B, RAF1, MTOR, ATP6V1C1
30	positive regulation of ERK1 and ERK2 cascade	GO:070374	16.7	SERPINF2, BRAF, VEGFB, BMP2, BMP4, KDR
31	positive regulation of gene expression	GO:010628	16.7	NCOA3, KIT, BRAF, VEGFA, VDR, BMP2
32	positive regulation of protein phosphorylation	GO:001934	16.5	PIN1, VEGFA, BMP2, BMP4, MT3, MTOR
33	cell migration	GO:016477	16.4	VAV2, LIMD1, PAK4, BDKRB1, LAMA5, CEACAM1
34	response to ethanol	GO:045471	16.2	RBP4, BGLAP, BCL2, BAK1, S100A8, S100A9
35	positive regulation of angiogenesis	GO:045766	16.0	SFRP2, SERPINE1, VEGFA, KDR, CHI3L1, MTDH
36	leukocyte migration	GO:050900	15.7	PIK3CA, BSG, LCK, YES1, L1CAM, MSN
37	induction of apoptosis by intracellular signals	GO:008629	15.6	MYC, BMF, CLU, BCL2, BCL2L1, BCL2L11
38	cellular response to hypoxia	GO:071456	15.6	SFRP1, VHL, VEGFA, LMNA, BMP7, BDKRB2
39	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	15.5	VCP, MYC, BCL2L11, LCK, BAD, BAX
40	aging	GO:007568	15.5	SERPINF1, VDR, VCAM1, BAK1, FURIN, JUN
41	keratinocyte differentiation	GO:030216	15.2	SFN, SCEL, YAP1, LATS2, S100A7, JAG1
42	positive regulation of MAPK cascade	GO:043410	15.1	KIT, LPAR3, KDR, LEP, CD36, CDH2
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	15.1	VTN, VEGFA, VEGFB, MTOR, JAK2, CD36
44	wound healing	GO:042060	15.0	KLF6, RAF1, PAK1, SDC2, S100A8, FGF10
45	positive regulation of cell division	GO:051781	14.9	VEGFA, VEGFB, VEGFC, YBX1, FIGF, FGF1
46	positive regulation of protein kinase B signaling cascade	GO:051897	14.8	PIK3CG, VEGFB, CHI3L1, MTDH, MTOR, AXL
47	angiogenesis	GO:001525	INF	PIK3CA, PIK3CG, PDE3B, WASF2, SETD2, SERPINE1
48	negative regulation of apoptotic process	GO:043066	INF	PIDD, PIK3CG, PIM1, PDE3A, RELA, SFRP1
49	negative regulation of cell proliferation	GO:008285	INF	KLF4, KISS1R, SFN, SFRP1, SFRP2, SFRP5
50	cytokine-mediated signaling pathway	GO:019221	INF	PIN1, KLF6, NCAM1, RELA, KIT, VCAM1

Molecular functions related to squamous cell carcinoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	ZNF639, PIK3CA, PIK3C2B, PIDD, PIK3CG, PIN1
2	ATP binding	GO:005524	INF	PIK3CA, PIK3C2B, PIK3C2A, PIK3CG, PIM1, RFC1
3	identical protein binding	GO:042802	22.7	RELA, SFRP1, PCNA, VIM, VCP, MYD88
4	protein kinase binding	GO:019901	21.4	RELA, VIM, PAK1, BCL10, BCL2L1, BCL2L14
5	enzyme binding	GO:019899	21.1	RFC5, NCOA1, VHL, RARA, RAC1, BLZF1
6	transcription factor binding	GO:008134	20.5	PIM1, RELA, RB1, RBL1, NBN, VHL
7	growth factor activity	GO:008083	19.1	VEGFA, VEGFB, VEGFC, BMP2, BMP4, BMP6
8	signal transducer activity	GO:004871	17.1	NCOA1, NCOA3, PDCD1, VOPP1, CLOCK, LGALS1
9	cytokine activity	GO:005125	16.8	VEGFA, BMP2, BMP4, BMP6, BMP7, MIF
10	heparin binding	GO:008201	15.7	VTN, SFRP1, SERPINE2, VEGFA, VEGFB, BMP4
11	sequence-specific DNA binding	GO:043565	INF	RERE, NANOG, VDR, MYC, RARG, RARA
12	sequence-specific DNA binding transcription factor activity	GO:003700	INF	ZNF639, KLF4, KLF6, RELA, RERE, RB1
13	transcription regulatory region DNA binding	GO:044212	INF	ZNF639, KLF4, NCOR1, RELA, CIITA, YAP1
14	protein homodimerization activity	GO:042803	INF	KIT, SERPINF2, VEGFA, VEGFB, BMP2, BMP4
15	receptor binding	GO:005102	INF	SERPINE2, SERPINE1, VCP, BMP2, RARA, RARRES2
16	protein heterodimerization activity	GO:046982	INF	BRAF, VEGFA, VEGFB, MYC, BMP2, BMP6