MCID: SQM006
MIFTS: 61

Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Squamous Cell Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Squamous cell carcinoma (scc) is the second most common skin cancer. scc most often affects individuals who are exposed to large amounts of sunlight. it is typically characterized by a red papule or plaque with a scaly or crusted surface; it may be suspected whenever a small, firm reddish-colored skin lesion, growth or bump appears on the skin, but it may also be a flat growth with a curly and crusted surface. most often these growths are located on the face, ears, neck, hands and/or arms, but they may occur on the lips, mouth, tongue, genitalia or other area. the most common causes of scc are radiation from the sun and arsenic exposure. with appropriate treatment, it is usually curable. last updated: 6/22/2011

MalaCards: Squamous Cell Carcinoma, also known as epidermoid carcinoma, is related to cervical squamous cell carcinoma and adenocarcinoma. An important gene associated with Squamous Cell Carcinoma is KDM4C (lysine (K)-specific demethylase 4C). The compound scca1 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and lymph node.

Disease Ontology:8 A carcinoma that derives from squamous epithelial cells.

Wikipedia:63 Squamous-cell carcinoma (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell. These... more...

Aliases & Classifications for Squamous Cell Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

squamous cell carcinoma 8 42 10 60
epidermoid carcinoma 8 42
squamous cell cancer 8 44
malignant squamous cell neoplasm 60
squamous cell carcinoma of skin 60
malignant squamous cell tumor 8
squamous cell carcinoma nos 8
squamous cell skin cancer 42
squamous cell epithelioma 8
carcinoma, squamous cell 42
carcinoma squamous cell 44
squamous carcinoma 8


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Disease Ontology8 DOID:1749
MeSH34 D002294
NCIt39 C2929

Related Diseases for Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 645)
idRelated DiseaseScoreTop Affiliating Genes
1cervical squamous cell carcinoma31.9TP63, SERPINB3
2adenocarcinoma31.8CTAG1B, CTTN, HRAS, MSLN, PTCH1, SERPINB4
3keratosis31.5SART3
4bladder carcinoma31.3CTAG1B, CTTN, HRAS, PTCH1, TP63
5transitional cell carcinoma31.3TP63, PTCH1, CTAG1B
6lung cancer31.2CTAG1B, HRAS, MSLN, SERPINB4, SERPINB3, TP63
7large cell carcinoma31.0HRAS, TP63
8papillary thyroid carcinoma30.9TP63, PTCH1, HRAS
9non-small cell lung carcinoma30.9TP63, MSLN, HRAS, CTAG1B
10hepatocellular carcinoma30.6CTAG1B, CTTN, HRAS, PTCH1, SERPINB3
11breast cancer30.6CTAG1B, CTTN, MSLN, PTCH1, TP63
12leiomyosarcoma30.5TP63
13oral cancer30.4SERPINB3, HRAS
14esophageal squamous cell carcinoma30.4DEC1
15esophagitis11.6
16laryngeal squamous cell carcinoma11.4
17laryngeal carcinoma11.4
18laryngitis11.4
19lung squamous cell carcinoma11.3
20cervicitis11.3
21skin squamous cell carcinoma11.2
22esophagus squamous cell carcinoma11.2
23basaloid squamous cell carcinoma11.1
24keratoacanthoma11.1
25basal cell carcinoma11.0
26in situ carcinoma11.0
27squamous cell papilloma11.0
28papilloma11.0
29lung adenocarcinoma11.0
30anal squamous cell carcinoma10.9
31actinic keratosis10.9
32small cell carcinoma10.9
33cystic teratoma10.9
34esophageal cancer10.9
35mature teratoma10.9
36epidermolysis bullosa10.9
37vulva squamous cell carcinoma10.9
38adenoid squamous cell carcinoma10.9
39gastric squamous cell carcinoma10.9
40bladder squamous cell carcinoma10.9
41verrucous carcinoma10.9
42adenoiditis10.9
43keratinizing squamous cell carcinoma10.8
44hypercalcemia10.8
45cervical cancer10.8
46lupus erythematosus10.8
47ovarian squamous cell carcinoma10.8
48maxillary sinus squamous cell carcinoma10.8
49gastric adenocarcinoma10.8
50mature teratoma of the ovary10.8

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma:



Diseases related to squamous cell carcinoma

Clinical Features for Squamous Cell Carcinoma

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Drugs & Therapeutics for Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Squamous Cell Carcinoma

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Anatomical Context for Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Squamous Cell Carcinoma:

32
Lung, Skin, Lymph node, Tongue, Cervix, Endothelial, T cells, Thyroid, Ovary, Bone, Prostate, Breast, Testes, Kidney, Liver, Monocytes, Tonsil, Testis, Bone marrow, Colon, Smooth muscle, Pituitary, Myeloid, Trachea, B cells, Placenta, Salivary gland, Nk cells, Eye, Thymus, Appendix, Pancreas, Spleen, Brain, Small intestine, Bronchial epithelium, Spinal cord, Adipocyte, Uterus, Whole blood, Hypothalamus

Animal Models for Squamous Cell Carcinoma or affiliated genes

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Publications for Squamous Cell Carcinoma

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50PubMed
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Articles related to Squamous Cell Carcinoma:

(show top 50)    (show all 9496)
idTitleAuthorsYear
1
Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma. (23634222)
2013
2
Association between XPD gene polymorphisms and esophageal squamous cell carcinoma. (23229387)
2013
3
Effects of postoperative chemotherapy and radiotherapy on patients with squamous cell carcinoma of the oral cavity and multiple regional lymph node metastases. (24387949)
2013
4
Papillary thyroid carcinoma and laryngeal squamous cell carcinoma manifesting as a collision tumor of the neck: A case report. (24260054)
2013
5
Images in clinical medicine. Lingual squamous-cell carcinoma. (24350952)
2013
6
A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations. (23872665)
2013
7
Pre- and postoperative treatment modalities for esophageal squamous cell carcinoma. (23155224)
2012
8
Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral squamous cell carcinoma in a Greek population. (22294102)
2012
9
Human papillomavirus DNA and p16 gene in squamous cell lung carcinoma. (22843877)
2012
10
Mutation of ING1 gene in laryngeal squamous cell carcinoma and its association with p33ING1b protein expression]. (22260079)
2011
11
miR-29c induces cell cycle arrest in esophageal squamous cell carcinoma by modulating cyclin E expression. (21551130)
2011
12
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma. (21163944)
2011
13
Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway. (20371243)
2010
14
TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed. (21036757)
2010
15
Increased expression of Cathepsin B in oral squamous cell carcinoma. (20042316)
2010
16
Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma. (21166694)
2010
17
Glucocorticoid receptor expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. (19697616)
2009
18
EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma. (18823699)
2009
19
c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines. (20121928)
2009
20
Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968. (18445521)
2008
21
Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. (18669583)
2008
22
Expression of EphA2 and VEGF in squamous cell carcinoma of the tongue: correlation with the angiogenesis and clinical outcome. (18485799)
2008
23
Coexistence of salivary gland cysticercosis with squamous cell carcinoma of the mandible. (17223588)
2007
24
The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model. (16533769)
2006
25
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck. (16899593)
2006
26
Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. (16436672)
2006
27
Dihydropyrimidine dehydrogenase expression predicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma. (15598584)
2005
28
Induction of p97MAPK expression regulates collagen mediated inhibition of proliferation and migration in human squamous cell carcinoma lines. (15067337)
2004
29
Dominant negative p63 isoform expression in head and neck squamous cell carcinoma. (15564824)
2004
30
The role of Bak expression in apoptosis of the oral squamous cell carcinoma (OSCC) and metastases to lymph nodes (LNMs). (15638360)
2004
31
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma. (15466188)
2004
32
Immunohistochemical study of cytokeratins in amyloid deposits associated with squamous cell carcinoma and dysplasia in the oral cavity, pharynx and larynx. (12713559)
2003
33
Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1. (12949073)
2003
34
Expression of annexin II in human esophageal squamous cell carcinoma]. (12921564)
2003
35
Apoptosis induction by interleukin-2-activated cytotoxic lymphocytes in a squamous cell carcinoma cell line and Daudi cells - involvement of reactive oxygen species-dependent cytochrome c and reactive oxygen species-independent apoptosis-inducing factors. (14511235)
2003
36
Expression of survivin and matrix metalloproteinases in adenocarcinoma and squamous cell carcinoma of the uterine cervix. (12469143)
2003
37
Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH. (12147242)
2002
38
Dowling-Degos disease associated with squamous cell carcinomas on the dappled pigmentation. (12207603)
2002
39
Evaluation of the anti-tumor and anti-angiogenic effect of paclitaxel and thalidomide on the xenotransplanted oral squamous cell carcinoma. (11165754)
2001
40
Alterations in MDM2 expression in esophageal squamous cell carcinoma: relationship with p53 status. (11692147)
2001
41
TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand. (11004672)
2000
42
Very young patient with peculiar squamous cell carcinoma of the lung. (10628938)
1999
43
Immunohistochemical and molecular analysis of bax, bcl-2 and p53 genes in laryngeal squamous cell carcinomas. (10368653)
1999
44
Immunohistochemical analysis for cell proliferation-related protein expression in small cell carcinoma of the esophagus; a comparative study with small cell carcinoma of the lung and squamous cell carcinoma of the esophagus. (10212809)
1999
45
Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. (9635682)
1998
46
Response of SCC-12F, a human squamous cell carcinoma cell line, to complement attack. (9204953)
1997
47
Interleukin-8 expression by head and neck squamous cell carcinoma. (7840929)
1995
48
A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (7724531)
1995
49
Expression of epidermal growth factor receptor in squamous cell carcinoma of the head and neck]. (8295066)
1993
50
Modulation of the production of a parathyroid hormone-like protein in human squamous carcinoma cell lines by interaction with fibroblasts. (2160322)
1990

Genetic Variations for Squamous Cell Carcinoma

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Expression for genes affiliated with Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma

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Pathways for genes affiliated with Squamous Cell Carcinoma

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Compounds for genes affiliated with Squamous Cell Carcinoma

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44Novoseek
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Compounds related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1scca14410.9SERPINB3, SERPINB4

GO Terms for genes affiliated with Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579411.8TP63, PTCH1, MSLN, HRAS, DSE, SART1

Biological processes related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinocyte proliferationGO:04361610.9TP63, PTCH1
2negative regulation of peptidase activityGO:01046610.6SERPINB3, SERPINB4

Products for genes affiliated with Squamous Cell Carcinoma

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Sources for Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet