MCID: SQM006
MIFTS: 61

Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Squamous Cell Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Squamous cell carcinoma (scc) is the second most common skin cancer. scc most often affects individuals who are exposed to large amounts of sunlight. it is typically characterized by a red papule or plaque with a scaly or crusted surface; it may be suspected whenever a small, firm reddish-colored skin lesion, growth or bump appears on the skin, but it may also be a flat growth with a curly and crusted surface. most often these growths are located on the face, ears, neck, hands and/or arms, but they may occur on the lips, mouth, tongue, genitalia or other area. the most common causes of scc are radiation from the sun and arsenic exposure. with appropriate treatment, it is usually curable. last updated: 6/22/2011

MalaCards: Squamous Cell Carcinoma, also known as squamous cell cancer, is related to cervical squamous cell carcinoma and adenocarcinoma. An important gene associated with Squamous Cell Carcinoma is KDM4C (lysine (K)-specific demethylase 4C). The compound scca1 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and lymph node.

Disease Ontology:8 A carcinoma that derives from squamous epithelial cells.

Wikipedia:63 Squamous-cell carcinoma (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell. These... more...

Aliases & Classifications for Squamous Cell Carcinoma

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60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

squamous cell carcinoma 8 42 10 60
squamous cell cancer 8 44
epidermoid carcinoma 8 42
malignant squamous cell neoplasm 60
squamous cell carcinoma of skin 60
malignant squamous cell tumor 8
squamous cell carcinoma nos 8
squamous cell epithelioma 8
squamous cell skin cancer 42
carcinoma, squamous cell 42
carcinoma squamous cell 44
squamous carcinoma 8


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Disease Ontology8 DOID:1749
MeSH34 D002294
NCIt39 C2929

Related Diseases for Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 645)
idRelated DiseaseScoreTop Affiliating Genes
1cervical squamous cell carcinoma31.9TP63, SERPINB3
2adenocarcinoma31.8CTAG1B, CTTN, HRAS, MSLN, PTCH1, SERPINB4
3keratosis31.5SART3
4bladder carcinoma31.3CTAG1B, CTTN, HRAS, PTCH1, TP63
5transitional cell carcinoma31.3TP63, PTCH1, CTAG1B
6lung cancer31.2CTAG1B, HRAS, MSLN, SERPINB4, SERPINB3, TP63
7large cell carcinoma31.0HRAS, TP63
8papillary thyroid carcinoma30.9TP63, PTCH1, HRAS
9non-small cell lung carcinoma30.9TP63, MSLN, HRAS, CTAG1B
10hepatocellular carcinoma30.6CTAG1B, CTTN, HRAS, PTCH1, SERPINB3
11breast cancer30.6CTAG1B, CTTN, MSLN, PTCH1, TP63
12leiomyosarcoma30.5TP63
13oral cancer30.4SERPINB3, HRAS
14esophageal squamous cell carcinoma30.4DEC1
15esophagitis11.6
16laryngeal squamous cell carcinoma11.4
17laryngeal carcinoma11.4
18laryngitis11.4
19lung squamous cell carcinoma11.3
20cervicitis11.3
21skin squamous cell carcinoma11.2
22esophagus squamous cell carcinoma11.2
23basaloid squamous cell carcinoma11.1
24keratoacanthoma11.1
25basal cell carcinoma11.0
26in situ carcinoma11.0
27squamous cell papilloma11.0
28papilloma11.0
29lung adenocarcinoma11.0
30anal squamous cell carcinoma10.9
31actinic keratosis10.9
32small cell carcinoma10.9
33cystic teratoma10.9
34esophageal cancer10.9
35mature teratoma10.9
36epidermolysis bullosa10.9
37vulva squamous cell carcinoma10.9
38adenoid squamous cell carcinoma10.9
39gastric squamous cell carcinoma10.9
40bladder squamous cell carcinoma10.9
41verrucous carcinoma10.9
42adenoiditis10.9
43keratinizing squamous cell carcinoma10.8
44hypercalcemia10.8
45cervical cancer10.8
46lupus erythematosus10.8
47ovarian squamous cell carcinoma10.8
48maxillary sinus squamous cell carcinoma10.8
49gastric adenocarcinoma10.8
50mature teratoma of the ovary10.8

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma:



Diseases related to squamous cell carcinoma

Clinical Features for Squamous Cell Carcinoma

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Drugs & Therapeutics for Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Squamous Cell Carcinoma

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Anatomical Context for Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Squamous Cell Carcinoma:

32
Lung, Skin, Lymph node, Tongue, Cervix, Endothelial, T cells, Thyroid, Ovary, Prostate, Bone, Breast, Testes, Kidney, Liver, Monocytes, Tonsil, Testis, Bone marrow, Pituitary, Smooth muscle, Colon, Myeloid, Trachea, B cells, Eye, Nk cells, Salivary gland, Placenta, Appendix, Pancreas, Thymus, Spleen, Small intestine, Brain, Bronchial epithelium, Adipocyte, Whole blood, Hypothalamus, Uterus, Spinal cord

Animal Models for Squamous Cell Carcinoma or affiliated genes

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Publications for Squamous Cell Carcinoma

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50PubMed
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Articles related to Squamous Cell Carcinoma:

(show top 50)    (show all 9496)
idTitleAuthorsYear
1
Fluctuating roles of matrix metalloproteinase-9 in oral squamous cell carcinoma. (23365550)
2013
2
Non-smoking non-drinking elderly females: a clinically distinct subgroup of oral squamous cell carcinoma patients. (23702369)
2013
3
Decreased expression of WWOX in the development of esophageal squamous cell carcinoma. (22213016)
2013
4
Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma. (24351917)
2013
5
Squamous cell carcinoma of the soft palate associated with autoantibodies to desmoglein 1 and 3. (24282668)
2013
6
Immune response in cervical lymph nodes from patients with primary oral squamous cell carcinoma. (23278174)
2013
7
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients. (23453030)
2013
8
Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck. (22086558)
2012
9
Knockdown of zinc finger protein, X-linked (ZFX) inhibits cell proliferation and induces apoptosis in human laryngeal squamous cell carcinoma. (22009483)
2012
10
Acquiring Metastatic Competence by Oral Squamous Cell Carcinoma Cells Is Associated with Differential Expression of I+-Tubulin Isoforms. (22719762)
2012
11
Over-expression of integrin-linked kinase correlates with aberrant expression of Snail, E-cadherin and N-cadherin in oral squamous cell carcinoma: implications in tumor progression and metastasis. (22638656)
2012
12
Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping. (22748473)
2012
13
Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients. (22818823)
2012
14
Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy. (21142704)
2011
15
Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines. (21085979)
2011
16
Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. (21847129)
2011
17
Potential role of the alcohol and smoking in the squamous cell carcinoma of the head and neck: review of the current literature and new perspectives. (21545191)
2011
18
Radiotherapy for laryngeal squamous cell carcinoma: current standards. (20836681)
2010
19
Primary gastric squamous cell carcinoma in situ originating from gastric squamous metaplasia. (21113875)
2010
20
Malignant hypercalcemia in a patient with maxillary sinus squamous cell carcinoma without skeletal metastases. (21457634)
2010
21
MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. (20838434)
2010
22
K-ras status in squamous cell anal carcinoma (SCC): it's time for target-oriented treatment? (19727729)
2009
23
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. (19606176)
2009
24
Preliminary study of proteomic shift from normal to premalignant laryngeal lesions and to laryngeal squamous cell carcinoma. (18821292)
2009
25
Expression of the WT1 gene -KTS domain isoforms suppresses the invasive ability of human lung squamous cell carcinoma cells. (18202757)
2008
26
Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma. (18990763)
2008
27
Up-regulation of VEGF-C secreted by cancer cells and not VEGF-A correlates with clinical evaluation of lymph node metastasis in esophageal squamous cell carcinoma (ESCC). (17011116)
2007
28
Combined modality treatment of laryngeal squamous cell carcinoma. (17338653)
2007
29
Correlations between serine hydroxymethyltransferase1 C1420T polymorphisms and susceptibilities to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (16536979)
2006
30
TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma. (15965904)
2006
31
Primary adenoid squamous cell carcinoma of the oral cavity. (16445819)
2006
32
Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma. (16564166)
2006
33
Peroxisome proliferator-activated receptors in squamous cell carcinoma and its precursors. (15811118)
2005
34
Targeted therapy of human laryngeal squamous cell carcinoma in vitro by antisense oligonucleotides directed against telomerase reverse transcriptase mRNA. (15829059)
2005
35
Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. (15246564)
2004
36
Constitutive expression of interleukin-18 in head and neck squamous carcinoma cells. (15162350)
2004
37
Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck. (15180941)
2004
38
The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma. (12845669)
2003
39
Correlation between expression of vascular endothelial growth factor and prognosis of patients with esophageal squamous cell carcinoma]. (12452000)
2002
40
Characterization of tumor-associated antigens on human oral squamous cell carcinomas using monoclonal antibody 3F8E3. (10778769)
2000
41
Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinomas. (10952783)
2000
42
Paraneoplastic syndromes of leukocytosis, thrombocytosis, and hypercalcemia associated with squamous cell carcinoma. (10405479)
1999
43
Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung. (10495320)
1999
44
Expression of CD44s, CD44v5, CD44v6 and CD44v7-8 in betel quid chewing-associated oral premalignant lesions and squamous cell carcinomas in Taiwan. (9790096)
1998
45
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. (9515818)
1998
46
Overexpression of the ERK/MAP kinases in oral squamous cell carcinoma. (9758369)
1998
47
Association of elevated protein kinase CK2 activity with aggressive behavior of squamous cell carcinoma of the head and neck. (8529132)
1995
48
Urethral squamous cell carcinoma associated with urethral stricture and urethroplasty. (8076714)
1994
49
Mutant p53 oncogene expression in keratoacanthoma and squamous cell carcinoma. (1476915)
1992
50
Development of squamous cell carcinoma in chronic discoid lupus erythematosus. (699369)
1978

Genetic Variations for Squamous Cell Carcinoma

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Expression for genes affiliated with Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma

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Pathways for genes affiliated with Squamous Cell Carcinoma

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Compounds for genes affiliated with Squamous Cell Carcinoma

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44Novoseek
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Compounds related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1scca14410.9SERPINB3, SERPINB4

GO Terms for genes affiliated with Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579411.8TP63, PTCH1, MSLN, HRAS, DSE, SART1

Biological processes related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinocyte proliferationGO:04361610.9TP63, PTCH1
2negative regulation of peptidase activityGO:01046610.6SERPINB3, SERPINB4

Products for genes affiliated with Squamous Cell Carcinoma

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Sources for Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet