MCID: SQM006
MIFTS: 61

Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Squamous Cell Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Squamous cell carcinoma (scc) is the second most common skin cancer. scc most often affects individuals who are exposed to large amounts of sunlight. it is typically characterized by a red papule or plaque with a scaly or crusted surface; it may be suspected whenever a small, firm reddish-colored skin lesion, growth or bump appears on the skin, but it may also be a flat growth with a curly and crusted surface. most often these growths are located on the face, ears, neck, hands and/or arms, but they may occur on the lips, mouth, tongue, genitalia or other area. the most common causes of scc are radiation from the sun and arsenic exposure. with appropriate treatment, it is usually curable. last updated: 6/22/2011

MalaCards: Squamous Cell Carcinoma, also known as squamous cell cancer, is related to cervical squamous cell carcinoma and adenocarcinoma. An important gene associated with Squamous Cell Carcinoma is KDM4C (lysine (K)-specific demethylase 4C). The compound scca1 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and lymph node.

Disease Ontology:8 A carcinoma that derives from squamous epithelial cells.

Wikipedia:63 Squamous-cell carcinoma (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell. These... more...

Aliases & Classifications for Squamous Cell Carcinoma

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60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

squamous cell carcinoma 8 42 10 60
squamous cell cancer 8 44
epidermoid carcinoma 8 42
malignant squamous cell neoplasm 60
squamous cell carcinoma of skin 60
malignant squamous cell tumor 8
squamous cell carcinoma nos 8
squamous cell epithelioma 8
squamous cell skin cancer 42
carcinoma, squamous cell 42
carcinoma squamous cell 44
squamous carcinoma 8


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Disease Ontology8 DOID:1749
MeSH34 D002294
NCIt39 C2929

Related Diseases for Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 645)
idRelated DiseaseScoreTop Affiliating Genes
1cervical squamous cell carcinoma31.9TP63, SERPINB3
2adenocarcinoma31.8CTAG1B, CTTN, HRAS, MSLN, PTCH1, SERPINB4
3keratosis31.5SART3
4bladder carcinoma31.3CTAG1B, CTTN, HRAS, PTCH1, TP63
5transitional cell carcinoma31.3TP63, PTCH1, CTAG1B
6lung cancer31.2CTAG1B, HRAS, MSLN, SERPINB4, SERPINB3, TP63
7large cell carcinoma31.0HRAS, TP63
8papillary thyroid carcinoma30.9TP63, PTCH1, HRAS
9non-small cell lung carcinoma30.9TP63, MSLN, HRAS, CTAG1B
10hepatocellular carcinoma30.6CTAG1B, CTTN, HRAS, PTCH1, SERPINB3
11breast cancer30.6CTAG1B, CTTN, MSLN, PTCH1, TP63
12leiomyosarcoma30.5TP63
13oral cancer30.4SERPINB3, HRAS
14esophageal squamous cell carcinoma30.4DEC1
15esophagitis11.6
16laryngeal squamous cell carcinoma11.4
17laryngeal carcinoma11.4
18laryngitis11.4
19lung squamous cell carcinoma11.3
20cervicitis11.3
21skin squamous cell carcinoma11.2
22esophagus squamous cell carcinoma11.2
23basaloid squamous cell carcinoma11.1
24keratoacanthoma11.1
25basal cell carcinoma11.0
26in situ carcinoma11.0
27squamous cell papilloma11.0
28papilloma11.0
29lung adenocarcinoma11.0
30anal squamous cell carcinoma10.9
31actinic keratosis10.9
32small cell carcinoma10.9
33cystic teratoma10.9
34esophageal cancer10.9
35mature teratoma10.9
36epidermolysis bullosa10.9
37vulva squamous cell carcinoma10.9
38adenoid squamous cell carcinoma10.9
39gastric squamous cell carcinoma10.9
40bladder squamous cell carcinoma10.9
41verrucous carcinoma10.9
42adenoiditis10.9
43keratinizing squamous cell carcinoma10.8
44hypercalcemia10.8
45cervical cancer10.8
46lupus erythematosus10.8
47ovarian squamous cell carcinoma10.8
48maxillary sinus squamous cell carcinoma10.8
49gastric adenocarcinoma10.8
50mature teratoma of the ovary10.8

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma:



Diseases related to squamous cell carcinoma

Clinical Features for Squamous Cell Carcinoma

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Drugs & Therapeutics for Squamous Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Squamous Cell Carcinoma

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Anatomical Context for Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Squamous Cell Carcinoma:

32
Lung, Skin, Lymph node, Tongue, Cervix, Endothelial, T cells, Thyroid, Ovary, Prostate, Bone, Breast, Testes, Kidney, Liver, Monocytes, Tonsil, Testis, Bone marrow, Pituitary, Smooth muscle, Colon, Myeloid, Trachea, B cells, Eye, Nk cells, Salivary gland, Placenta, Appendix, Pancreas, Thymus, Spleen, Small intestine, Brain, Bronchial epithelium, Adipocyte, Whole blood, Hypothalamus, Uterus, Spinal cord

Animal Models for Squamous Cell Carcinoma or affiliated genes

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Publications for Squamous Cell Carcinoma

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50PubMed
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Articles related to Squamous Cell Carcinoma:

(show top 50)    (show all 9496)
idTitleAuthorsYear
1
Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: a meta-analysis of observational studies. (23319052)
2013
2
MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression. (24427326)
2013
3
Prognostic value of histamine H1 receptor expression in oral squamous cell carcinoma. (22782258)
2013
4
Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis. (23969487)
2013
5
Immunohistochemical analysis of O(6)-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma. (23460078)
2013
6
L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study. (23083099)
2012
7
Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status. (21720999)
2012
8
Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma. (22576742)
2012
9
Squamous cell carcinoma of the head and neck in the elderly. (24381743)
2012
10
Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma. (23082988)
2012
11
Oral candidiasis mimicking an oral squamous cell carcinoma: report of a case. (20633054)
2012
12
Increased expression of Rab coupling protein in squamous cell carcinoma of the head and neck and its clinical significance. (22783424)
2012
13
E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice. (21779166)
2011
14
Expression of phosphatase of regenerating liver-3 in squamous cell carcinoma of the cervix. (20364335)
2011
15
The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C. (20827282)
2011
16
Reduced expression of I9I9p63I+ inA cervical squamous cell carcinoma. (21631996)
2011
17
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (21642993)
2011
18
Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus. (20652977)
2011
19
Involvement of the Wnt-I^-catenin pathway in invasion and migration of oral squamous carcinoma cells. (20878057)
2010
20
Histological changes after single high-dose irradiation for squamous cell carcinoma arising from a burn scar. (19214812)
2010
21
Class III beta-tubulin, but not ERCC1, is a strong predictive and prognostic marker in locally advanced head and neck squamous cell carcinoma. (19468031)
2009
22
Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma. (19414369)
2009
23
Galectin-8 expression in laryngeal squamous cell carcinoma. (19434286)
2009
24
Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101. (17237265)
2007
25
Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors. (17912441)
2007
26
Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. (16373199)
2006
27
ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma. (17033202)
2006
28
Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8. (16273203)
2005
29
Endostatin inhibits nitric oxide and diminishes VEGF and collagen XVIII in squamous carcinoma cells. (15540202)
2005
30
Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. (16322297)
2005
31
Comparative proteomic analysis of esophageal squamous cell carcinoma. (15986332)
2005
32
Expression of Ki-67 and p53 in laryngeal squamous cell carcinomas]. (16340285)
2005
33
Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. (15213722)
2004
34
Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. (12599217)
2003
35
Anti-tumor effect of vitamin A and D on head and neck squamous cell carcinoma. (14656567)
2003
36
Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma. (14613080)
2003
37
Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma. (12712472)
2003
38
Langerhans cell related inflammatory reaction in laryngeal squamous cell carcinoma. (12589856)
2003
39
Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16(INK4a) tumor suppressor. (11804749)
2002
40
Okadaic acid stimulates apoptosis through expression of Fas receptor and Fas ligand in human oral squamous carcinoma cells. (11755816)
2002
41
Bax and Bcl-X(L) expression are not related to prognosis in patients with advanced esophageal squamous cell carcinoma. (11675156)
2001
42
Angiogenesis and expression of platelet-derived endothelial cell growth factor in oral squamous cell carcinoma. (9216858)
1997
43
p53 mutations in squamous cell carcinoma of the head and neck predominate in a subgroup of former and present smokers with a low frequency of genetic instability. (9307295)
1997
44
Relative changes of MIB1 and PC10 labeling indexes in cell kinetics during radiotherapy for cervical squamous cell carcinoma. (9490095)
1997
45
Squamous cell carcinomas of the head and neck cultured in floating collagen gels: 1. The maintenance of stromal and epithelial elements in vitro without fibroblast overgrowth. (9051067)
1997
46
Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss. (7646764)
1995
47
Establishment of highly metastatic tumor clones derived from a skin squamous cell carcinoma (SqC-NH), D-1 and F-3, with distinct features of pulmonary metastases. (8319380)
1993
48
Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma. (1741121)
1992
49
Invasive squamous cell carcinoma initially diagnosed as a giant keratoacanthoma. (6368620)
1984
50
Proliferating trichilemmal cyst: a simulant of squamous cell carcinoma. (6268280)
1981

Genetic Variations for Squamous Cell Carcinoma

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Expression for genes affiliated with Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma

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Pathways for genes affiliated with Squamous Cell Carcinoma

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Compounds for genes affiliated with Squamous Cell Carcinoma

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44Novoseek
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Compounds related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1scca14410.9SERPINB3, SERPINB4

GO Terms for genes affiliated with Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579411.8TP63, PTCH1, MSLN, HRAS, DSE, SART1

Biological processes related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinocyte proliferationGO:04361610.9TP63, PTCH1
2negative regulation of peptidase activityGO:01046610.6SERPINB3, SERPINB4

Products for genes affiliated with Squamous Cell Carcinoma

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Sources for Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet