MCID: SQM006
MIFTS: 58

Squamous Cell Carcinoma malady

Skin, Cancer categories

Summaries for Squamous Cell Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Squamous cell carcinoma (scc) is the second most common skin cancer. scc most often affects individuals who are exposed to large amounts of sunlight. it is typically characterized by a red papule or plaque with a scaly or crusted surface; it may be suspected whenever a small, firm reddish-colored skin lesion, growth or bump appears on the skin, but it may also be a flat growth with a curly and crusted surface. most often these growths are located on the face, ears, neck, hands and/or arms, but they may occur on the lips, mouth, tongue, genitalia or other area. the most common causes of scc are radiation from the sun and arsenic exposure. with appropriate treatment, it is usually curable. last updated: 6/22/2011

MalaCards: Squamous Cell Carcinoma, also known as squamous cell cancer, is related to esophageal squamous cell carcinoma and adenocarcinoma. An important gene associated with Squamous Cell Carcinoma is KDM4C (lysine (K)-specific demethylase 4C). The compound scca1 have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver.

Disease Ontology:8 A carcinoma that derives from squamous epithelial cells.

Wikipedia:64 Squamous-cell carcinoma (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell. These... more...

Aliases & Classifications for Squamous Cell Carcinoma

Sources:
61UMLS, 8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 35MeSH, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin


Aliases & Descriptions:

squamous cell carcinoma 8 43 10 61
squamous cell cancer 8 45
epidermoid carcinoma 8 43
malignant squamous cell neoplasm 61
squamous cell carcinoma of skin 61
malignant squamous cell tumor 8
squamous cell carcinoma nos 8
squamous cell epithelioma 8
squamous cell skin cancer 43
carcinoma, squamous cell 43
carcinoma squamous cell 45
squamous carcinoma 8


External Ids:

Disease Ontology8 DOID:1749
MeSH35 D002294
NCIt40 C2929

Related Diseases for Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 562)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal squamous cell carcinoma32.4DEC1
2adenocarcinoma31.8TP63, SERPINB4, PTCH1, MSLN, HRAS, CTTN
3bladder carcinoma31.3HRAS, CTTN, CTAG1B, TP63, PTCH1
4oral cancer31.3HRAS, SERPINB3
5large cell carcinoma31.0TP63, HRAS
6transitional cell carcinoma30.8CTAG1B, TP63, PTCH1
7oral squamous cell carcinoma11.7
8anal squamous cell carcinoma11.4
9squamous cell papilloma11.3
10basal cell carcinoma11.2
11skin squamous cell carcinoma11.2
12basaloid squamous cell carcinoma11.2
13vulva squamous cell carcinoma11.1
14hypoxia11.0
15teratoma11.0
16actinic keratosis11.0
17small cell carcinoma11.0
18leukoplakia10.9
19oral leukoplakia10.9
20adenoid squamous cell carcinoma10.9
21gastric squamous cell carcinoma10.9
22bladder squamous cell carcinoma10.9
23verrucous carcinoma10.9
24lichen sclerosus10.8
25hypercalcemia10.8
26ovarian squamous cell carcinoma10.8
27recessive dystrophic epidermolysis bullosa10.8
28maxillary sinus squamous cell carcinoma10.8
29discoid lupus erythematosus10.8
30bone carcinoma10.8
31papillary squamous carcinoma10.8
32colon squamous cell carcinoma10.8
33papillary carcinoma10.8
34lichen planus10.8
35porokeratosis10.8
36parathyroid carcinoma10.7
37conjunctiva squamous cell carcinoma10.7
38fanconi's anemia10.7
39oral lichen planus10.7
40vulvar intraepithelial neoplasia10.7
41keratinizing squamous cell carcinoma10.7
42gastric cardia adenocarcinoma10.7
43spindle cell carcinoma10.7
44cervical intraepithelial neoplasia10.7
45epidermodysplasia verruciformis10.7
46endometrial squamous cell carcinoma10.7
47hidradenitis suppurativa10.7
48burn scar10.7
49xeroderma pigmentosum10.7
50adenosquamous carcinoma10.6

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma:



Diseases related to squamous cell carcinoma

Clinical Features for Squamous Cell Carcinoma

Drugs & Therapeutics for Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Squamous Cell Carcinoma

Search NIH Clinical Center for Squamous Cell Carcinoma

Search CenterWatch for Squamous Cell Carcinoma

Genetic Tests for Squamous Cell Carcinoma

Anatomical Context for Squamous Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Squamous Cell Carcinoma:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Uterus, Bone marrow, Whole blood, Thymus, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Placenta, Prostate, Testis, Cervix, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Hypothalamus, Trachea, Bronchial epithelium, Appendix, Pituitary, Uterus corpus, Testis germ

Animal Models for Squamous Cell Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Squamous Cell Carcinoma

Sources:
51PubMed
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Articles related to Squamous Cell Carcinoma:

(show top 50)    (show all 9506)
idTitleAuthorsYear
1
Regulation of Interleukin-6 in Head and Neck Squamous Cell Carcinoma Is Related to Papillomavirus Infection. (24405156)
2014
2
Tumour response and safety of cetuximab in a window pre-operative study in patients with squamous cell carcinoma of the head and neck. (23704200)
2013
3
The diagnostic value of methylated DNA in laryngeal squamous cell carcinoma: meta-analysis. (23466793)
2013
4
Education and Imaging. Gastrointestinal: advanced untreated anal canal squamous cell carcinoma. (23692575)
2013
5
The association between serum Dickkopf-1 levels and esophageal squamous cell carcinoma. (24220876)
2013
6
Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. (24376802)
2013
7
Relationship between the Argyrophilic Proteins of the Nucleolar Organizer Region and Stage of Squamous-Cell Carcinoma of the Lung. (24319736)
2013
8
Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma. (23511560)
2013
9
Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma. (23817697)
2013
10
The relevance of mast cells in oral squamous cell carcinoma. (23373059)
2012
11
The method of en face frozen section in clearing periocular basal cell carcinoma and squamous cell carcinoma. (22671704)
2012
12
Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck. (21293244)
2012
13
Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis. (22006371)
2012
14
Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas. (22718118)
2012
15
Chemokine receptor 7 (CCR7) gene expression is regulated by NF-I_B and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN). (22158872)
2012
16
Expression of the T cell receptor I+I^ on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma. (21264308)
2011
17
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. (21883368)
2011
18
Squamous cell carcinoma arising from an ovarian teratoma related to human papillomavirus infection: using a PCR-based reverse-blot assay. (22212336)
2011
19
The expression of PEBP4 protein in lung squamous cell carcinoma. (21887552)
2011
20
Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. (19795456)
2010
21
Clinical nodal staging of T1-2 tonsillar squamous cell carcinoma stratified by p16 status and implications for ipsilateral neck irradiation. (20526108)
2010
22
Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. (19170169)
2009
23
Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells. (19319529)
2009
24
Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma. (19002186)
2008
25
Nuclear translocation of HER-4/c-erbB-4 is significantly correlated with prognosis of esophageal squamous cell carcinoma. (18000820)
2008
26
Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells. (17909904)
2008
27
Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma. (17475541)
2008
28
Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. (18949399)
2008
29
Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis. (18257926)
2008
30
Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis]. (18250037)
2008
31
High-level expression of CD109 is frequently detected in lung squamous cell carcinomas. (17922683)
2007
32
Aspirin inhibits the proliferation of tobacco-related esophageal squamous carcinomas cell lines through cyclooxygenase 2 pathway. (18167181)
2007
33
Prognostic significance of p53 and p63 immunolocalisation in primary and matched lymph node metastasis in oral squamous cell carcinoma. (17499344)
2007
34
Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma. (16783828)
2006
35
A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma. (15774466)
2005
36
Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. (16000588)
2005
37
The prevalence of oral leukoplakia in 138 patients with oral squamous cell carcinoma. (15533209)
2004
38
Chemoprevention of squamous cell carcinoma in recessive dystrophic epidermolysis bullosa: results of a phase 1 trial of systemic isotretinoin. (15034505)
2004
39
GSTM1 polymorphism and oral squamous cell carcinoma. (14662415)
2004
40
Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study. (14551748)
2004
41
Characterization of proteins associated with heat shock protein hsp27 in the squamous cell carcinoma cell line A431. (11779227)
2002
42
PPARgamma-mediated antineoplastic effect of NSAID sulindac on human oral squamous carcinoma cells. (11948457)
2002
43
Induction of S100A4 gene expression inhibits in vitro invasiveness of human squamous cell carcinoma, KOSC-3 cells. (10737717)
2000
44
Squamous cell carcinoma of the lung mimicking an ectopic mediastinal parathyroid adenoma demonstrated by Tc-99m sestamibi in a hypercalcemic patient. (10551480)
1999
45
5-Fluorouracil dose intensification and granulocyte-macrophage colony-stimulating factor in cisplatin-based chemotherapy for relapsed squamous cell carcinoma of the head and neck: a phase II study. (9626807)
1998
46
Cytodiagnosis of pure primary squamous-cell carcinoma of the breast by fine-needle aspiration cytology. (9285191)
1997
47
Expression of squamous cell carcinoma-associated antigen in bladder cancer cells--a comparative study with the expression of proliferating cell nuclear antigen (PCNA)]. (7910645)
1994
48
Annexin I and involucrin are cross-linked by particulate transglutaminase into the cornified cell envelope of squamous cell carcinoma Y1. (1348694)
1992
49
Endometrial squamous cell carcinoma: report of three cases and review of the literature. (2180795)
1990
50
Bowenoid papulosis and squamous cell carcinoma of the genitalia: suspected sexual transmission. (3030665)
1987

Genetic Variations for Squamous Cell Carcinoma

Expression for genes affiliated with Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma

Search GEO for disease gene expression data for Squamous Cell Carcinoma.

Pathways for genes affiliated with Squamous Cell Carcinoma

Compounds for genes affiliated with Squamous Cell Carcinoma

Sources:
45Novoseek
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Compounds related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1scca14510.9SERPINB3, SERPINB4

GO Terms for genes affiliated with Squamous Cell Carcinoma

Sources:
16Gene Ontology
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Cellular components related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579411.8TP63, PTCH1, MSLN, HRAS, DSE, SART1

Biological processes related to Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinocyte proliferationGO:04361610.9TP63, PTCH1
2negative regulation of peptidase activityGO:01046610.6SERPINB3, SERPINB4

Products for genes affiliated with Squamous Cell Carcinoma

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Sources for Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet