MCID: SQM009
MIFTS: 10

Squamous Cell Carcinoma, Head and Neck, Somatic malady

Cancer category

Summaries for Squamous Cell Carcinoma, Head and Neck, Somatic

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47OMIM, 33MalaCards
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MalaCards: Squamous Cell Carcinoma, Head and Neck, Somatic is related to osteosarcoma and astrocytoma. An important gene associated with Squamous Cell Carcinoma, Head and Neck, Somatic is PTEN (phosphatase and tensin homolog), and among its related pathways is Senescence and Autophagy. The compounds etoposide and estrogen have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

Description from OMIM:47 275355

Aliases & Classifications for Squamous Cell Carcinoma, Head and Neck, Somatic

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

squamous cell carcinoma, head and neck, somatic 47


Related Diseases for Squamous Cell Carcinoma, Head and Neck, Somatic

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma, Head and Neck, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma10.0ING1
2astrocytoma10.0PTEN
3squamous cell carcinoma of the head and neck10.0ING1, PTEN
4brain cancer10.0PTEN, ING1
5colorectal cancer10.0PTEN, ING1
6malignant glioma10.0ING1, PTEN
7squamous cell carcinoma10.0ING1, PTEN

Graphical network of diseases related to Squamous Cell Carcinoma, Head and Neck, Somatic:



Diseases related to squamous cell carcinoma, head and neck, somatic

Clinical Features for Squamous Cell Carcinoma, Head and Neck, Somatic

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47OMIM
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Clinical features from OMIM:

275355

Drugs & Therapeutics for Squamous Cell Carcinoma, Head and Neck, Somatic

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Squamous Cell Carcinoma, Head and Neck, Somatic

Drug clinical trials:

Search ClinicalTrials for Squamous Cell Carcinoma, Head and Neck, Somatic

Search NIH Clinical Center for Squamous Cell Carcinoma, Head and Neck, Somatic

Search CenterWatch for Squamous Cell Carcinoma, Head and Neck, Somatic

Genetic Tests for Squamous Cell Carcinoma, Head and Neck, Somatic

Anatomical Context for Squamous Cell Carcinoma, Head and Neck, Somatic

Animal Models for Squamous Cell Carcinoma, Head and Neck, Somatic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Squamous Cell Carcinoma, Head and Neck, Somatic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1PTEN, ING1

Publications for Squamous Cell Carcinoma, Head and Neck, Somatic

Genetic Variations for Squamous Cell Carcinoma, Head and Neck, Somatic

Expression for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

Search GEO for disease gene expression data for Squamous Cell Carcinoma, Head and Neck, Somatic.

Pathways for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

Sources:
38NCBI BioSystems Database
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Pathways related to Squamous Cell Carcinoma, Head and Neck, Somatic according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PTEN, ING1

Compounds for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank
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Compounds related to Squamous Cell Carcinoma, Head and Neck, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1etoposide45 50 60 1112.1PTEN, ING1
2estrogen459.1PTEN, ING1
3paclitaxel45 50 1111.0PTEN, ING1
4cisplatin45 50 60 1111.8PTEN, ING1

GO Terms for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

Sources:
16Gene Ontology
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Biological processes related to Squamous Cell Carcinoma, Head and Neck, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:0082859.1PTEN, ING1

Products for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

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Sources for Squamous Cell Carcinoma, Head and Neck, Somatic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet