MCID: SQM009
MIFTS: 18

Squamous Cell Carcinoma, Head and Neck, Somatic malady

Cancer diseases category

Summaries for Squamous Cell Carcinoma, Head and Neck, Somatic

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46OMIM, 32MalaCards
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MalaCards: Squamous Cell Carcinoma, Head and Neck, Somatic is related to osteosarcoma and astrocytoma. An important gene associated with Squamous Cell Carcinoma, Head and Neck, Somatic is PTEN (phosphatase and tensin homolog), and among its related pathways is Senescence and Autophagy. The compounds etoposide and estrogen have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

Description from OMIM:46 275355

Aliases & Classifications for Squamous Cell Carcinoma, Head and Neck, Somatic

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

squamous cell carcinoma, head and neck, somatic 46


Related Diseases for Squamous Cell Carcinoma, Head and Neck, Somatic

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17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma, Head and Neck, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma10.0ING1
2astrocytoma10.0PTEN
3squamous cell carcinoma of the head and neck10.0PTEN, ING1
4brain cancer10.0PTEN, ING1
5colorectal cancer10.0ING1, PTEN
6malignant glioma10.0PTEN, ING1
7squamous cell carcinoma10.0PTEN, ING1

Graphical network of diseases related to Squamous Cell Carcinoma, Head and Neck, Somatic:



Diseases related to squamous cell carcinoma, head and neck, somatic

Clinical Features for Squamous Cell Carcinoma, Head and Neck, Somatic

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46OMIM
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Clinical features from OMIM:

275355

Drugs & Therapeutics for Squamous Cell Carcinoma, Head and Neck, Somatic

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Squamous Cell Carcinoma, Head and Neck, Somatic

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Anatomical Context for Squamous Cell Carcinoma, Head and Neck, Somatic

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Animal Models for Squamous Cell Carcinoma, Head and Neck, Somatic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Squamous Cell Carcinoma, Head and Neck, Somatic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1PTEN, ING1

Publications for Squamous Cell Carcinoma, Head and Neck, Somatic

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Genetic Variations for Squamous Cell Carcinoma, Head and Neck, Somatic

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Squamous Cell Carcinoma, Head and Neck, Somatic:

62
id Symbol AA change Variation ID SNP ID
1ING1p.Ala335AspVAR_017420
2ING1p.Cys358SerVAR_017421
3ING1p.Asn359SerVAR_017422
4ING3p.Asp20GlyVAR_021263
5PTENp.Ala121GlyVAR_018103

Expression for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

Search GEO for disease gene expression data for Squamous Cell Carcinoma, Head and Neck, Somatic.

Pathways for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

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37NCBI BioSystems Database
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Pathways related to Squamous Cell Carcinoma, Head and Neck, Somatic according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1PTEN, ING1

Compounds for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Squamous Cell Carcinoma, Head and Neck, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1etoposide44 49 59 1112.1PTEN, ING1
2estrogen449.1PTEN, ING1
3paclitaxel44 49 1111.0PTEN, ING1
4cisplatin44 49 59 1111.8PTEN, ING1

GO Terms for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

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16Gene Ontology
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Biological processes related to Squamous Cell Carcinoma, Head and Neck, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:0082859.1PTEN, ING1

Products for genes affiliated with Squamous Cell Carcinoma, Head and Neck, Somatic

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Sources for Squamous Cell Carcinoma, Head and Neck, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet