HNSCC
MCID: SQM007
MIFTS: 42

Squamous Cell Carcinoma of the Head and Neck (HNSCC) malady

Cancer category

Summaries for Squamous Cell Carcinoma of the Head and Neck

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Head and neck cancer refers to a group of biologically similar cancers that start in the lip, oral... more...

MalaCards: Squamous Cell Carcinoma of the Head and Neck, also known as head and neck squamous cell carcinoma, is related to squamous cell carcinoma and basal cell carcinoma. An important gene associated with Squamous Cell Carcinoma of the Head and Neck is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are Rho Family GTPases and PAK Pathway. The compounds 5fluorouracil and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related mouse phenotypes are cellular and tumorigenesis.

Description from OMIM:47 275355

Aliases & Classifications for Squamous Cell Carcinoma of the Head and Neck

Sources:
43NIH Rare Diseases, 61UMLS, 22GTR, 49Orphanet, 45Novoseek, 47OMIM, 36MESH via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
head and neck squamous cell carcinoma:
Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

squamous cell carcinoma of the head and neck 43
head and neck squamous cell carcinoma 43 22 49
hnscc 43 45 49
carcinoma, squamous cell of head and neck 43 61
squamous cell carcinoma of head and neck 49
squamous cell carcinoma, head and neck 47


External Ids:

OMIM47 275355
MESH via Orphanet36 C535575
UMLS via Orphanet62 C1168401

Related Diseases for Squamous Cell Carcinoma of the Head and Neck

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma of the Head and Neck via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.8CCR7, OGFR, XRCC1, CSTA, TNFRSF10B, CTTN
2basal cell carcinoma31.5XRCC1, IVL, ERCC1, ERCC2
3leukoplakia30.8IVL
4colorectal cancer30.8CCR7, XRCC1, TNFRSF10B, ING1, PTEN, ERCC1
5adenocarcinoma30.6OGFR, XRCC1, CSTA, TNFRSF10B, CTTN, IVL
6bladder carcinoma30.5XRCC1, TNFRSF10B, CTTN, ERCC1, ERCC2
7anal squamous cell carcinoma11.1
8squamous cell papilloma11.0
9basaloid squamous cell carcinoma11.0
10oral squamous cell carcinoma10.8
11skin squamous cell carcinoma10.7
12papillary carcinoma10.6
13papillary squamous carcinoma10.6
14small cell carcinoma10.6
15colon squamous cell carcinoma10.6
16hypoxia10.6
17ataxia telangiectasia10.6
18ataxia10.6
19bone carcinoma10.6
20adenoid squamous cell carcinoma10.6
21prostate squamous cell carcinoma10.6
22esophageal squamous cell carcinoma10.6
23fanconi's anemia10.5
24squamous cell carcinoma, head and neck, somatic10.5
25parathyroid carcinoma10.4
26myelitis10.4
27hepatitis c10.4
28prostate small cell carcinoma10.4
29spindle cell carcinoma10.4
30hypercalcemia10.4
31n syndrome10.4
32adenoid cystic carcinoma10.4
33acne10.4
34mutagen sensitivity10.4
35radiation induced cancer10.4
36dysphagia10.4
37hepatitis c virus10.4
38radiation myelitis10.4
39verrucous carcinoma10.4
40lung cancer susceptibility10.4
41parkinson's disease10.3
42marantic endocarditis10.3
43dyskeratosis congenita10.3
44diphtheria10.3
45vaccinia10.3
46anal margin squamous cell carcinoma10.3
47oral submucous fibrosis10.3
48bladder neck cancer10.3
49bladder lymphoma10.3
50prostate lymphoma10.3

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma of the Head and Neck:



Diseases related to squamous cell carcinoma of the head and neck

Clinical Features for Squamous Cell Carcinoma of the Head and Neck

Sources:
47OMIM
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Clinical features from OMIM:

275355

Clinical synopsis from OMIM:

275355

Drugs & Therapeutics for Squamous Cell Carcinoma of the Head and Neck

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Squamous Cell Carcinoma of the Head and Neck

Drug clinical trials:

Search ClinicalTrials for Squamous Cell Carcinoma of the Head and Neck

Search NIH Clinical Center for Squamous Cell Carcinoma of the Head and Neck

Search CenterWatch for Squamous Cell Carcinoma of the Head and Neck

Genetic Tests for Squamous Cell Carcinoma of the Head and Neck

Sources:
22GTR
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Genetic tests related to Squamous Cell Carcinoma of the Head and Neck:

id Genetic test Affiliating Genes
1 Squamous Cell Carcinoma Of The Head And Neck22

Anatomical Context for Squamous Cell Carcinoma of the Head and Neck

Sources:
33MalaCards
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MalaCards organs/tissues related to Squamous Cell Carcinoma of the Head and Neck:

33
Lymph node

Animal Models for Squamous Cell Carcinoma of the Head and Neck or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Squamous Cell Carcinoma of the Head and Neck:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.2PMAIP1, CCR7, XRCC1, TNFRSF10B, CTTN, ING1
2MP:000200610.7PMAIP1, XRCC1, TNFRSF10B, ING1, PTEN, ERCC1

Publications for Squamous Cell Carcinoma of the Head and Neck

Genetic Variations for Squamous Cell Carcinoma of the Head and Neck

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

63
id Symbol AA change Variation SNP ID
1ING1p.Ala335AspVAR_017420
2ING1p.Cys358SerVAR_017421
3ING1p.Asn359SerVAR_017422
4ING3p.Asp20GlyVAR_021263
5PTENp.Ala121GlyVAR_018103

Expression for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Search GEO for disease gene expression data for Squamous Cell Carcinoma of the Head and Neck.

Pathways for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome
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Compounds for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR
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Compounds related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
15fluorouracil4511.2ERCC2, PTEN, IVL, TNFRSF10B, XRCC1, ERCC1
2tyrosine4511.2ERCC1, PENK, XRCC1, PTEN, IVL, CTTN
3cisplatin45 50 60 1114.2TNFRSF10B, ERCC2, ERCC1, PTEN, ING1, XRCC1
4etoposide45 50 60 1114.1XRCC1, TNFRSF10B, ING1, PTEN, ERCC1
5paclitaxel45 50 1113.1ERCC2, TNFRSF10B, ERCC1, PTEN
6oxaliplatin45 50 1113.1TNFRSF10B, XRCC1, ERCC1, ERCC2
7irinotecan45 50 1113.1XRCC1, ERCC2, ERCC1, TNFRSF10B
8pd 98,0594511.0PENK, ERCC1, IVL, PTEN, CTTN
9gemcitabine45 50 1113.0ERCC2, TNFRSF10B, PTEN, ERCC1
10platinum compounds5011.0ERCC2, XRCC1, ERCC1
11cyclophosphamide45 50 1112.9PTEN, XRCC1, ERCC2, ERCC1
12platinum45 5011.9ERCC2, ERCC1, XRCC1
13vegf4510.9ERCC2, TNFRSF10B, IVL, PTEN, ERCC1
14vincristine45 50 1112.8PTEN, ERCC2, ERCC1
15oligonucleotide4510.8PENK, ERCC1, PTEN, XRCC1, IVL
16thymidylate4510.7XRCC1, ERCC1, ERCC2
17gw966245 2911.3PTEN, TNFRSF10B

GO Terms for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Sources:
16Gene Ontology
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Cellular components related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:00153310.6IVL, CSTA

Biological processes related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1UV protectionGO:00965010.6ERCC2, ERCC1
2peptide cross-linkingGO:01814910.6IVL, CSTA
3response to X-rayGO:01016510.5ERCC1, PMAIP1
4nucleotide-excision repair, DNA damage removalGO:00071810.3ERCC2, ERCC1

Products for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Sources for Squamous Cell Carcinoma of the Head and Neck

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet