HNSCC
MCID: SQM007
MIFTS: 56

Squamous Cell Carcinoma of the Head and Neck (HNSCC) malady

Genetic diseases, Rare diseases, Cancer diseases categories

Summaries for Squamous Cell Carcinoma of the Head and Neck

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Head and neck cancer refers to a group of biologically similar cancers that start in the lip, oral... more...

MalaCards: Squamous Cell Carcinoma of the Head and Neck, also known as head and neck squamous cell carcinoma, is related to squamous cell carcinoma, head and neck, somatic and colorectal cancer. An important gene associated with Squamous Cell Carcinoma of the Head and Neck is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are Akt Signaling and p53 signaling pathway. The compounds gw9662 and gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and t cells, and related mouse phenotypes are tumorigenesis and immune system.

Description from OMIM:48 275355

Aliases & Classifications for Squamous Cell Carcinoma of the Head and Neck

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44NIH Rare Diseases, 63UMLS, 23GTR, 50Orphanet, 46Novoseek, 48OMIM, 37MESH via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Orphanet: 50 
Rare tumors


Characteristics (Orphanet epidemiological data):

50
head and neck squamous cell carcinoma:
Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

squamous cell carcinoma of the head and neck 44
head and neck squamous cell carcinoma 44 23 50
hnscc 44 46 50
carcinoma, squamous cell of head and neck 44 63
squamous cell carcinoma of head and neck 50
squamous cell carcinoma, head and neck 48


External Ids:

OMIM48 275355
MESH via Orphanet37 C535575
UMLS via Orphanet64 C1168401

Related Diseases for Squamous Cell Carcinoma of the Head and Neck

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18GeneCards, 19GeneDecks
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Diseases related to Squamous Cell Carcinoma of the Head and Neck via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma, head and neck, somatic30.9PTEN, ING1
2colorectal cancer30.9ERCC2, CCR7, PTEN, TNFRSF10B, ING1
3breast cancer30.9ERCC2, TNFRSF10B, ING1, PENK, CSTA, PTEN
4lung cancer30.7PTEN, ERCC2
5adenocarcinoma30.6CSTA, PTEN, PENK, ING1, OGFR, TNFRSF10B
6non-small cell lung carcinoma30.6PTEN, TNFRSF10B, ERCC2, CCR7, CSTA
7melanoma30.6CCR7, PTEN, TNFRSF10B, ING1, ERCC2
8basaloid squamous cell carcinoma11.0
9endotheliitis10.9
10cervicitis10.8
11papilloma10.8
12dermatitis10.7
13hypoxia10.7
14ataxia telangiectasia10.6
15leukoplakia10.6
16ataxia10.6
17adenoiditis10.6
18esophagitis10.6
19prostatitis10.6
20leukemia10.5
21periodontitis10.5
22retinoblastoma10.5
23hepatitis c10.4
24myelitis10.4
25adenoid squamous cell carcinoma10.4
26nasopharyngitis10.4
27hypercalcemia10.4
28adenoid cystic carcinoma10.4
29acne10.4
30esophageal cancer10.4
31hepatitis10.4
32herpes simplex10.4
33leiomyosarcoma10.4
34prostate adenocarcinoma10.4
35prostate cancer10.4
36thyroiditis10.4
37mutagen sensitivity10.4
38radiation induced cancer10.4
39syndrome of inappropriate antidiuretic hormone10.4
40dysphagia10.4
41pituitary tumors10.4
42hepatitis c virus10.4
43esophageal squamous cell carcinoma10.4
44radiation myelitis10.4
45verrucous carcinoma10.4
46lung cancer susceptibility10.4
47dyskeratosis congenita10.4
48marantic endocarditis10.4
49diphtheria10.4
50vaccinia10.4

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma of the Head and Neck:



Diseases related to squamous cell carcinoma of the head and neck

Symptoms for Squamous Cell Carcinoma of the Head and Neck

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48OMIM
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Symptoms by clinical synopsis from OMIM:

275355

Clinical features from OMIM:

275355

Drugs & Therapeutics for Squamous Cell Carcinoma of the Head and Neck

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Squamous Cell Carcinoma of the Head and Neck

Drug clinical trials:

Search ClinicalTrials for Squamous Cell Carcinoma of the Head and Neck

Search NIH Clinical Center for Squamous Cell Carcinoma of the Head and Neck

Search CenterWatch for Squamous Cell Carcinoma of the Head and Neck

Genetic Tests for Squamous Cell Carcinoma of the Head and Neck

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23GTR
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Genetic tests related to Squamous Cell Carcinoma of the Head and Neck:

id Genetic test Affiliating Genes
1 Squamous Cell Carcinoma of the Head and Neck23

Anatomical Context for Squamous Cell Carcinoma of the Head and Neck

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34MalaCards
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MalaCards organs/tissues related to Squamous Cell Carcinoma of the Head and Neck:

34
Lymph node, Endothelial, T cells, Skin, Lung, Breast, Bone, Prostate, Testes, Testis, Bone marrow, Thyroid, Pituitary

Animal Models for Squamous Cell Carcinoma of the Head and Neck or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Squamous Cell Carcinoma of the Head and Neck:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4ING1, PMAIP1, TNFRSF10B, PTEN, ERCC2
2MP:00053879.3DEFB103A, ING1, PMAIP1, TNFRSF10B, PTEN, CCR7

Publications for Squamous Cell Carcinoma of the Head and Neck

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53PubMed
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Articles related to Squamous Cell Carcinoma of the Head and Neck:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
A phase II trial of biweekly gemcitabine and paclitaxel with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN): SWOG study S0329. (24166832)
2013
2
A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck. (22371453)
2012
3
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck. (22548841)
2012
4
Selective neck dissection in node-positive squamous cell carcinoma of the head and neck. (22517013)
2012
5
Bovine papillomavirus type 1 and Equus caballus papillomavirus 2 in equine squamous cell carcinoma of the head and neck in a Connemara mare. (21668491)
2012
6
Phase II Study of Gemcitabine and Docetaxel Combination in Patients with Previously Treated Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. (22655205)
2012
7
Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck. (22513208)
2012
8
XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. (21737503)
2011
9
S-1 monotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck after progression on platinum-based chemotherapy. (21980053)
2011
10
Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. (21653686)
2011
11
Metastases of squamous cell carcinoma of the head and neck show increased levels of nucleotide excision repair protein XPF in vivo that correlate with increased chemoresistance ex vivo. (20372803)
2010
12
Small atypical cervical nodes detected on sonography in patients with squamous cell carcinoma of the head and neck: probability of metastasis. (20375372)
2010
13
MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck. (20682983)
2010
14
CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neck. (20577877)
2010
15
Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response. (20309553)
2010
16
Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. (19917840)
2010
17
Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420. (20498388)
2010
18
Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. (18632233)
2009
19
Weekly docetaxel in patients with platinum-refractory metastatic or recurrent squamous cell carcinoma of the head and neck. (19381630)
2009
20
A contemporary review of indications for primary surgical care of patients with squamous cell carcinoma of the head and neck. (19718757)
2009
21
Squamous cell carcinoma of the head and neck: ESMO clinical recommendations for diagnosis, treatment and follow-up. (19454430)
2009
22
Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. (17764087)
2008
23
High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival. (17957792)
2008
24
Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. (17785763)
2008
25
Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. (18496144)
2008
26
Down-regulation of Mcl-1 with antisense technology alters the effect of various cytotoxic agents used in treatment of squamous cell carcinoma of the head and neck. (18497956)
2008
27
The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. (17975141)
2007
28
TP53 mutations and survival in squamous-cell carcinoma of the head and neck. (18094376)
2007
29
Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma of the head and neck. (17667135)
2007
30
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. (17118968)
2007
31
Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck. (17029632)
2006
32
EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. (16615113)
2006
33
A study of TRAIL receptors in squamous cell carcinoma of the head and neck. (15897419)
2005
34
Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck. (16322265)
2005
35
The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times. (16024113)
2005
36
Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck. (15608423)
2005
37
Combination of mutated herpes simplex virus type 1 (G207 virus) with radiation for the treatment of squamous cell carcinoma of the head and neck. (15661558)
2005
38
Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck. (15608417)
2005
39
Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration. (14654962)
2004
40
Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck. (15585623)
2004
41
Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck. (14735195)
2004
42
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. (12771142)
2003
43
Inactivation of p53 and amplification of cyclin D1 in squamous cell carcinomas of the head and neck]. (12185899)
2002
44
Squamous cell carcinoma of the head and neck. (17955573)
2002
45
Human squamous cell carcinomas of the head and neck chemoattract immune suppressive CD34(+) progenitor cells. (11295465)
2001
46
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. (11710599)
2001
47
EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. (10955801)
2000
48
Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck. (9049184)
1997
49
Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. (7867006)
1995
50
Investigation of urinary transforming growth factor alpha levels as tumor markers in patients with advanced squamous cell carcinoma of the head and neck. (2211102)
1990

Variations for Squamous Cell Carcinoma of the Head and Neck

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

65
id Symbol AA change Variation ID SNP ID
1ING1p.Ala335AspVAR_017420
2ING1p.Cys358SerVAR_017421
3ING1p.Asn359SerVAR_017422
4ING3p.Asp20GlyVAR_021263
5PTENp.Ala121GlyVAR_018103

Clinvar genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

1
id Gene Name Type Significance SNP ID Assembly Location
1TNFRSF10BTNFRSF10B, 2-BP INSinsertionPathogenic
2PTENNM_000314.4(PTEN): c.362C> G (p.Ala121Gly)single nucleotide variantPathogenicrs121909237GRCh37Chr 10, 89692878: 89692878
3ING1NM_198217.2(ING1): c.512G> C (p.Cys171Ser)single nucleotide variantPathogenicrs121909250GRCh37Chr 13, 111372083: 111372083
4ING1NM_198217.2(ING1): c.515A> G (p.Asn172Ser)single nucleotide variantPathogenicrs121909251GRCh37Chr 13, 111372086: 111372086
5ING1NM_198217.2(ING1): c.443C> A (p.Ala148Asp)single nucleotide variantPathogenicrs121909252GRCh37Chr 13, 111372014: 111372014

Expression for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Search GEO for disease gene expression data for Squamous Cell Carcinoma of the Head and Neck.

Pathways for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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51PathCards, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gw966246 3011.2TNFRSF10B, PTEN
2gemcitabine46 52 1212.1ERCC2, PTEN, TNFRSF10B
35fluorouracil4610.0TNFRSF10B, PTEN, ERCC2
4paclitaxel46 52 1211.8ERCC2, PTEN, TNFRSF10B, ING1, PENK
5naltrexone46 30 52 1212.8OGFR, PENK
6cisplatin46 52 62 1212.7ING1, TNFRSF10B, PTEN, ERCC2

GO Terms for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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17Gene Ontology
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Biological processes related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:0069159.8ERCC2, PTEN, TNFRSF10B, PMAIP1

Products for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Sources for Squamous Cell Carcinoma of the Head and Neck

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet