HNSCC
MCID: SQM007
MIFTS: 63

Squamous Cell Carcinoma of the Head and Neck (HNSCC) malady

Genetic diseases, Rare diseases, Cancer diseases categories
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Summaries for Squamous Cell Carcinoma of the Head and Neck

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MedlinePlus:33 Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes in the neck. most begin in the moist tissues that line the mouth, nose and throat. symptoms include a lump or sore that does not heal a sore throat that does not go away trouble swallowing a change or hoarseness in the voice using tobacco or alcohol increases your risk. in fact, 85 percent of head and neck cancers are linked to tobacco use, including smoking and smokeless tobacco. if found early, these cancers are often curable. treatments may include surgery, radiation therapy, chemotherapy or a combination. treatments can affect eating, speaking or even breathing, so patients may need rehabilitation. nih: national cancer institute

MalaCards based summary: Squamous Cell Carcinoma of the Head and Neck, also known as carcinoma, squamous cell of head and neck, is related to squamous cell carcinoma, head and neck, somatic and colorectal cancer, and has symptoms including An important gene associated with Squamous Cell Carcinoma of the Head and Neck is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are p53 signaling pathway and MicroRNAs in cancer. The compounds panitumumab and gw9662 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, salivary gland and t cells, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:8 A head and neck carcinoma that has material basis in squamous cells that line the moist, mucosal surfaces inside the head and neck.

Wikipedia:65 Head and neck cancer refers to a group of biologically similar cancers that start in the lip, oral... more...

Description from OMIM:46 275355

Aliases & Classifications for Squamous Cell Carcinoma of the Head and Neck

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 9diseasecard, 46OMIM, 22GTR, 44Novoseek, 33MedlinePlus, 34MeSH, 39NCIt, 35MESH via Orphanet, 63UMLS via Orphanet
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Squamous Cell Carcinoma of the Head and Neck, Aliases & Descriptions:

Name: Squamous Cell Carcinoma of the Head and Neck 30 8 42
Carcinoma, Squamous Cell of Head and Neck 42 22 62
Head and Neck Squamous Cell Carcinoma 8 42 48
Hnscc 42 44 48
Squamous Cell Carcinoma, Head and Neck 9 46
Carcinoma of the Neck 8 62
 
Head and Neck Cancer 33 62
Neck Cancer 44 62
Squamous Cell Carcinomas of Head and Neck 8
Squamous Cell Carcinoma of Head and Neck 48
Carcinoma of the Head and Neck 8
Head and Neck Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
head and neck squamous cell carcinoma:
Prevalence: 1-5/10000; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:5520, DOID:1542
OMIM46 275355
MeSH34 C535575
MESH via Orphanet35 C535575
UMLS via Orphanet63 C1168401

Related Diseases for Squamous Cell Carcinoma of the Head and Neck

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Diseases related to Squamous Cell Carcinoma of the Head and Neck via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma, head and neck, somatic31.6PTEN, ING1
2colorectal cancer31.0ING1, TNFRSF10B, PTEN, EGFR
3melanoma30.9ING1, TNFRSF10B, PTEN, CCR7, ERCC2
4breast cancer30.7EGFR, ERCC2, CSTA, PTEN
5lung cancer30.6ING1, TNFRSF10B, CSTA, ERCC2, EGFR
6non-small cell lung carcinoma30.5TNFRSF10B, PTEN, CCR7, CSTA, ERCC2, EGFR
7prostate cancer30.5TNFRSF10B, PTEN, CSTA, ERCC2, EGFR
8adenocarcinoma30.4PENK, ING1, TNFRSF10B, PTEN, CSTA, ERCC2
9pancreatic cancer29.9PENK, TNFRSF10B, CCR7, OGFR, EGFR
10ovarian cancer29.8EGFR, ERCC2, CCR7, PTEN, TNFRSF10B
11basaloid squamous cell carcinoma11.0
12cervicitis10.9
13endotheliitis10.9
14merkel cell carcinoma10.8
15papilloma10.8
16dermatitis10.7
17hypoxia10.7
18verrucous carcinoma10.7
19neuroendocrine carcinoma10.6
20ataxia telangiectasia10.6
21leukoplakia10.6
22ataxia10.6
23adenoiditis10.6
24esophagitis10.6
25prostatitis10.6
26large cell neuroendocrine carcinoma10.6
27small cell carcinoma10.6
28adenosquamous carcinoma10.6
29spindle cell carcinoma10.6
30gemistocytic astrocytoma10.6PTEN
31leukemia10.5
32periodontitis10.5
33retinoblastoma10.5
34basal cell carcinoma10.5
35gliosarcoma10.5PTEN
36acne10.4
37esophageal cancer10.4
38hepatitis10.4
39hepatitis c10.4
40myelitis10.4
41adenoid squamous cell carcinoma10.4
42hypercalcemia10.4
43nasopharyngitis10.4
44herpes simplex10.4
45leiomyosarcoma10.4
46prostate adenocarcinoma10.4
47thyroiditis10.4
48mutagen sensitivity10.4
49radiation induced cancer10.4
50syndrome of inappropriate antidiuretic hormone10.4

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma of the Head and Neck:



Diseases related to squamous cell carcinoma of the head and neck

Symptoms for Squamous Cell Carcinoma of the Head and Neck

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Symptoms by clinical synopsis from OMIM:

275355

Clinical features from OMIM:

275355

HPO human phenotypes related to Squamous Cell Carcinoma of the Head and Neck:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 squamous cell carcinoma HP:0002860

Drugs & Therapeutics for Squamous Cell Carcinoma of the Head and Neck

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Drug clinical trials:

Search ClinicalTrials for Squamous Cell Carcinoma of the Head and Neck

Search NIH Clinical Center for Squamous Cell Carcinoma of the Head and Neck

Genetic Tests for Squamous Cell Carcinoma of the Head and Neck

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Genetic tests related to Squamous Cell Carcinoma of the Head and Neck:

id Genetic test Affiliating Genes
1 Squamous Cell Carcinoma of the Head and Neck22

Anatomical Context for Squamous Cell Carcinoma of the Head and Neck

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MalaCards organs/tissues related to Squamous Cell Carcinoma of the Head and Neck:

32
Lymph node, Salivary gland, T cells, Endothelial, Skin, Lung, Breast, Bone, Prostate, Testes, Bone marrow, Thyroid, Testis, Pituitary

Animal Models for Squamous Cell Carcinoma of the Head and Neck or affiliated genes

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MGI Mouse Phenotypes related to Squamous Cell Carcinoma of the Head and Neck:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.6ING1, PMAIP1, TNFRSF10B, PTEN, ERCC2, EGFR
2MP:00053979.5EGFR, ING1, PMAIP1, TNFRSF10B, PTEN, ERCC2
3MP:00053879.1EGFR, DEFB103A, ERCC2, ING1, CCR7, PTEN

Publications for Squamous Cell Carcinoma of the Head and Neck

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Articles related to Squamous Cell Carcinoma of the Head and Neck:

(show top 50)    (show all 757)
idTitleAuthorsYear
1
Risk factors for and pre-medications to prevent cetuximab-induced infusion reactions in patients with squamous cell carcinoma of the head and neck. (25037161)
2014
2
A phase II trial of biweekly gemcitabine and paclitaxel with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN): SWOG study S0329. (24166832)
2013
3
A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck. (22371453)
2012
4
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck. (22548841)
2012
5
Selective neck dissection in node-positive squamous cell carcinoma of the head and neck. (22517013)
2012
6
Bovine papillomavirus type 1 and Equus caballus papillomavirus 2 in equine squamous cell carcinoma of the head and neck in a Connemara mare. (21668491)
2012
7
Phase II Study of Gemcitabine and Docetaxel Combination in Patients with Previously Treated Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. (22655205)
2012
8
Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck. (22513208)
2012
9
XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. (21737503)
2011
10
S-1 monotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck after progression on platinum-based chemotherapy. (21980053)
2011
11
Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. (21653686)
2011
12
Metastases of squamous cell carcinoma of the head and neck show increased levels of nucleotide excision repair protein XPF in vivo that correlate with increased chemoresistance ex vivo. (20372803)
2010
13
Small atypical cervical nodes detected on sonography in patients with squamous cell carcinoma of the head and neck: probability of metastasis. (20375372)
2010
14
MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck. (20682983)
2010
15
CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neck. (20577877)
2010
16
Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response. (20309553)
2010
17
Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. (19917840)
2010
18
Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420. (20498388)
2010
19
Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. (18632233)
2009
20
Weekly docetaxel in patients with platinum-refractory metastatic or recurrent squamous cell carcinoma of the head and neck. (19381630)
2009
21
A contemporary review of indications for primary surgical care of patients with squamous cell carcinoma of the head and neck. (19718757)
2009
22
Squamous cell carcinoma of the head and neck: ESMO clinical recommendations for diagnosis, treatment and follow-up. (19454430)
2009
23
Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. (17764087)
2008
24
High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival. (17957792)
2008
25
Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. (17785763)
2008
26
Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. (18496144)
2008
27
Down-regulation of Mcl-1 with antisense technology alters the effect of various cytotoxic agents used in treatment of squamous cell carcinoma of the head and neck. (18497956)
2008
28
The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. (17975141)
2007
29
TP53 mutations and survival in squamous-cell carcinoma of the head and neck. (18094376)
2007
30
Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma of the head and neck. (17667135)
2007
31
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. (17118968)
2007
32
Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck. (17029632)
2006
33
EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. (16615113)
2006
34
Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. (16685459)
2006
35
A study of TRAIL receptors in squamous cell carcinoma of the head and neck. (15897419)
2005
36
Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck. (16322265)
2005
37
The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times. (16024113)
2005
38
Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck. (15608423)
2005
39
Combination of mutated herpes simplex virus type 1 (G207 virus) with radiation for the treatment of squamous cell carcinoma of the head and neck. (15661558)
2005
40
Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck. (15608417)
2005
41
Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration. (14654962)
2004
42
Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck. (15585623)
2004
43
Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck. (14735195)
2004
44
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. (12771142)
2003
45
Inactivation of p53 and amplification of cyclin D1 in squamous cell carcinomas of the head and neck]. (12185899)
2002
46
Human squamous cell carcinomas of the head and neck chemoattract immune suppressive CD34(+) progenitor cells. (11295465)
2001
47
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. (11710599)
2001
48
EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. (10955801)
2000
49
Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck. (9049184)
1997
50
Investigation of urinary transforming growth factor alpha levels as tumor markers in patients with advanced squamous cell carcinoma of the head and neck. (2211102)
1990

Variations for Squamous Cell Carcinoma of the Head and Neck

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UniProtKB/Swiss-Prot genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

64
id Symbol AA change Variation ID SNP ID
1ING1p.Ala335AspVAR_017420
2ING1p.Cys358SerVAR_017421
3ING1p.Asn359SerVAR_017422
4ING3p.Asp20GlyVAR_021263
5PTENp.Ala121GlyVAR_018103

Clinvar genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

6 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1NM_005228.3(EGFR): c.2327G> A (p.Arg776His)single nucleotide variantdrug responsers483352806GRCh37Chr 7, 55249029: 55249029
2EGFRNM_005228.3(EGFR): c.2471G> A (p.Gly824Asp)single nucleotide variantdrug responsers483352808GRCh38Chr 7, 55191720: 55191720
3EGFRNM_005228.3(EGFR): c.2188C> G (p.Leu730Val)single nucleotide variantdrug responsers121913434GRCh37Chr 7, 55242418: 55242418
4NM_005228.3(EGFR): c.2393T> A (p.Leu798His)single nucleotide variantdrug responsers483352807GRCh38Chr 7, 55181402: 55181402
5EGFRNM_005228.3(EGFR): c.2176G> A (p.Val726Met)single nucleotide variantdrug responsers483352805GRCh37Chr 7, 55241728: 55241728
6EGFRNM_005228.3(EGFR): c.2155G> C (p.Gly719Arg)single nucleotide variantLikely pathogenicrs28929495GRCh37Chr 7, 55241707: 55241707
7TNFRSF10BTNFRSF10B, 2-BP INSinsertionPathogenic
8PTENNM_000314.4(PTEN): c.362C> G (p.Ala121Gly)single nucleotide variantPathogenicrs121909237GRCh37Chr 10, 89692878: 89692878
9ING1NM_198217.2(ING1): c.512G> C (p.Cys171Ser)single nucleotide variantPathogenicrs121909250GRCh37Chr 13, 111372083: 111372083
10ING1NM_198217.2(ING1): c.515A> G (p.Asn172Ser)single nucleotide variantPathogenicrs121909251GRCh37Chr 13, 111372086: 111372086
11ING1NM_198217.2(ING1): c.443C> A (p.Ala148Asp)single nucleotide variantPathogenicrs121909252GRCh37Chr 13, 111372014: 111372014

Expression for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Search GEO for disease gene expression data for Squamous Cell Carcinoma of the Head and Neck.

Pathways for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Compounds for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Compounds related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1112.5EGFR, PTEN
2gw966244 2811.5TNFRSF10B, PTEN
3bortezomib44 50 1112.4EGFR, PTEN, TNFRSF10B
4oxaliplatin44 50 1112.3EGFR, ERCC2, TNFRSF10B
5mg 13244 6111.3PTEN, EGFR, TNFRSF10B
6irinotecan44 50 1112.3EGFR, TNFRSF10B, ERCC2
7gemcitabine44 50 1112.3EGFR, TNFRSF10B, PTEN, ERCC2
8imatinib44 50 1112.3EGFR, CCR7, PTEN
9vinorelbine44 50 1112.2EGFR, ERCC2
10naltrexone44 28 50 1113.2OGFR, PENK
11taxane4410.2PTEN, EGFR
12cetuximab44 50 1112.2PTEN, EGFR
135fluorouracil4410.2TNFRSF10B, PTEN, ERCC2, EGFR
14cisplatin44 50 61 1113.1ERCC2, PTEN, TNFRSF10B, ING1, EGFR
15bcnu4410.1ERCC2, EGFR
16paclitaxel44 50 1112.0PTEN, ERCC2, EGFR, ING1, PENK, TNFRSF10B
17cycloheximide449.7PTEN, EGFR, PENK, TNFRSF10B

GO Terms for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Products for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Sources for Squamous Cell Carcinoma of the Head and Neck

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet