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HNSCC
MCID: SQM007

Squamous Cell Carcinoma of the Head and Neck malady
2 drugs, 220 genes, 9 tissues, 933 related diseases, 29 phenotypes, 314 articles, clinical trials.

Summaries for Squamous Cell Carcinoma of the Head and Neck

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44Wikipedia, 33OMIM, 22MalaCards
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Wikipedia: Head and neck cancer refers to a group of biologically similar cancers that start in the lip, oral...44 more...

MalaCards: Squamous Cell Carcinoma of the Head and Neck, also known as HNSCC, is related to squamous cell carcinoma and keratoacanthoma. An important gene associated with Squamous Cell Carcinoma of the Head and Neck is CTTN (cortactin), and among its related pathways are Transcription P53 signaling pathway and Signal transduction_PTEN pathway. The drugs bleomycin sulfate and bleomycin and the compounds lysine and gold have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and breast, and related mouse phenotypes are respiratory system and craniofacial.

OMIM: 275355

Aliases & Descriptions for Squamous Cell Carcinoma of the Head and Neck

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30NIH Rare Diseases, 33OMIM, 32Novoseek , 43UMLS
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squamous cell carcinoma of the head and neck 30
hnscc 30 32
carcinoma, squamous cell of head and neck 30
squamous cell carcinoma, head and neck 33
head and neck squamous cell carcinoma 30
squamous cell carcinoma 43

Related Diseases for Squamous Cell Carcinoma of the Head and Neck

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13GeneCards, 14GeneDecks
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Diseases related to squamous cell carcinoma of the head and neck by text searches and GeneDecks gene sharing:

(show top 50)    (show all 930)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma44.4LGALS1, CD44, CDH1, MMP10, MMP7, MKI67
2keratoacanthoma36.6PCNA, BCL2, CDKN1A, CD44, IVL, MMP1
3basaloid squamous cell carcinoma36.3PCNA, MYC, BAX, CDKN1B, CDKN2A, CDH1
4carcinoma35.9PIK3CA, PIK3CG, NCAM1, RELA, VTN, PCNA
5basal cell carcinoma35.7BCL2, LGALS1, BAX, XRCC1, XRCC3, CD44
6keratosis35.4PIK3CA, PCNA, MYC, BCL2, CDKN1A, CDKN1B
7cervical squamous cell carcinoma35.2MYC, BCL2, BAX, CDKN1A, CDKN1B, CDKN2A
8actinic keratosis35.2PCNA, MYC, BCL2, CDKN1B, CDKN2A, MMP1
9laryngeal squamous cell carcinoma34.8PCNA, VEGFA, VEGFC, MYC, BCL2, LGALS1
10leukoplakia34.4PCNA, BCL2, BAX, XRCC1, CDKN1B, CDKN2A
11maxillary sinus squamous cell carcinoma34.1PCNA, VEGFA, BAX, CDKN1A, GSTP1, FGF2
12esophageal squamous cell carcinoma34.1PIK3CA, NCAM1, RELA, PCNA, SELE, VEGFA
13cystic teratoma34.0MUC16, CDKN2A, TP53, PTEN, PTGS2, PTHLH
14pharyngitis33.7PIK3CA, PCNA, VEGFA, BCL2, YES1, CDKN2A
15verrucous carcinoma33.7PCNA, CDKN1A, CDKN2A, CD44, CDH1, MDM2
16lichen sclerosus33.6CDKN2A, CD44, IVL, IL2RA, IL2RB, MDM2
17epidermolysis bullosa33.6JUN, CDKN2A, IVL, ITGB4, MMP1, MMP10
18inverted papilloma33.5PCNA, BCL2, CDKN1A, CDKN1B, CDKN2A, CD44
19teratoma33.4PCNA, BCL2, CHEK2, MUC16, BAX, JUN
20recessive dystrophic epidermolysis bullosa33.2JUN, CDKN2A, IVL, MMP1, MMP3, FGF2
21laryngitis33.0PIK3CA, RELA, PCNA, VEGFA, VEGFC, MYC
22adenosquamous carcinoma32.9IVL, FHIT, TP63, PTHLH, CTSD, KRT19
23tongue cancer32.9VEGFC, LGALS1, CDKN1A, CDH1, MMP2, MMP9
24actinic cheilitis32.7BAX, CDKN1A, MMP9, MKI67, MDM2, APEX1
25colorectal cancer32.7CHEK2, MTHFR, MTR, MLH1, GSTM1, GSTP1
26xeroderma pigmentosum32.6PCNA, PARP1, BCL2, BAX, XRCC1, XRCC3
27esophagitis32.5PIK3CA, PIK3CG, NCAM1, RELA, PCNA, SELE
28hypercalcemia32.3FGF2, IL2, IL2RB, IL3, CCND1, IFNG
29cheilitis32.2BAX, CDKN1A, MMP9, MKI67, MDM2, APEX1
30oral squamous cell carcinoma32.2PIK3CA, VTN, PCNA, SELE, BRAF, VEGFA
31acne32.1JUN, MMP1, MMP2, MMP9, IL4, IGF1R
32adenoid cystic carcinoma32.0NCAM1, PCNA, CEACAM3, CDH1, MKI67, CCND1
33small cell carcinoma31.7NCAM1, PCNA, VEGFA, BCL2, CHEK2, BAX
34large cell carcinoma31.6CEACAM3, IVL, HRAS, ERBB2, TP63, PTHLH
35hepatitis31.6CD58, IL2RB, FASLG, FAS, IFNA1, IFNA2
36esophagus adenocarcinoma31.5BCL2, CDKN1A, CDKN2A, MKI67, CCND1, TP53
37fanconi's anemia31.5PCNA, RAD51, PARP1, KDR, BCL2, XPC
38dna topoisomerase ii31.4PCNA, MYC, JUN, CDKN1A, MKI67, GSTP1
39adenomatous polyposis coli31.3PIK3CG, MYC, KHDRBS1, BCL2, CDKN1A, CDH1
40leiomyosarcoma31.2PCNA, VEGFA, MYC, BCL2, LGALS1, MUC16
41lung occult squamous cell carcinoma31.1PCNA, BRAF, BCL2, MTOR, JUN, CDKN1A
42pituitary tumor31.0PIK3CA, NCAM1, PCNA, VEGFA, MYC, PARP1
43oral lichen planus30.9VCAM1, BAX, CD58, MMP1, CASP3, TP63
44basaloid squamous cell skin carcinoma30.7PARP1, CDH1, IL10, FAT2, IFNA1, CASP3
45trichoepithelioma30.5BCL2, CDH1, IVL, MMP11, MKI67, PDPN
46pleomorphic carcinoma30.5CDKN1B, IVL, TP53, PDPN, KRT18, EGFR
47intraepithelial neoplasm30.5PCNA, XRCC1, CDKN2A, MKI67, ERBB2, TP53
48skin melanoma30.4PCNA, CDKN1A, CDKN2A, MMP2, MLH1, MKI67
49gastric cardia adenocarcinoma30.3MYC, MTHFR, MMP13, MMP2, PTGS2, CTSB
50mucoepidermoid carcinoma30.2PCNA, CDKN1B, CD9, IVL, MKI67, TP63

Graphical network of the top 20 diseases related to squamous cell carcinoma of the head and neck:



Graphical network of diseases related to squamous cell carcinoma of the head and neck

Clinical Features for Squamous Cell Carcinoma of the Head and Neck

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33OMIM
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Clinical features from OMIM: 275355

Drugs & Therapeutics for Squamous Cell Carcinoma of the Head and Neck

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for squamous cell carcinoma of the head and neck

Drug clinical trials:

Search ClinicalTrials for squamous cell carcinoma of the head and neck

Search NIH Clinical Center for squamous cell carcinoma of the head and neck

Search CenterWatch for squamous cell carcinoma of the head and neck

Inferred drug relations via UMLS/NDF-RT:

43 28 bleomycin, bleomycin sulfate

Genetic Tests for Squamous Cell Carcinoma of the Head and Neck

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Anatomical Context for Squamous Cell Carcinoma of the Head and Neck

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22MalaCards
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MalaCards organs/tissues related to squamous cell carcinoma of the head and neck:

22
Lymph node, Lung, Breast, Skin, Prostate, T cells, B cells, Endothelial, Pituitary

Phenotypes for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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25MGI
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MGI Mouse Phenotypes related to squamous cell carcinoma of the head and neck:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.7TP63
2craniofacial phenotypeMP:000538210.6BMI1, FOXP3, ILK, IGF1R, ALDH1A1, CASP9
3endocrine/exocrine gland phenotypeMP:000537910.3CDKN1B, IL2, IL2RB, FASLG, IFNG, ALDH1A1
4pigmentation phenotypeMP:00011869.9BRAF, MYC, BCL2, CDKN1B, CDKN2A, ITGB1
5renal/urinary system phenotypeMP:00053679.7BRAF, BCL2, BAX, YES1, MTOR, CDKN1A
6no phenotypic analysisMP:00030129.7PCNA, VEGFA, VCAM1, MYC, PARP1, UBE2I
7normal phenotypeMP:00028739.7RELA, VTN, SELE, BRAF, VEGFA, MYC
8limbs/digits/tail phenotypeMP:00053719.4RELA, VEGFA, BMI1, BAX, MTHFR, CD44
9embryogenesis phenotypeMP:00053809.3PIK3CA, BRAF, MYC, BMI1, RAD51, PARP1
10liver/biliary system phenotypeMP:00053709.2VEGFA, IL2, APEX1, IFNG, ALDH1A1, HSD11B1
11other phenotypeMP:00053958.8KDR, CDKN2A, ITGB1, IL2, ILK, TP73
12adipose tissue phenotypeMP:00053758.6PIK3CA, BRAF, MYC, KHDRBS1, BCL2, MTOR
13hearing/vestibular/ear phenotypeMP:00053778.5MYC, PARP1, BCL2, BAX, CDKN1A, CDKN1B
14skeleton phenotypeMP:00053908.5PIK3CG, RELA, BRAF, VEGFA, MYC, BMI1
15nervous system phenotypeMP:00036318.4RELA, BRAF, MYC, BMI1, PARP1, LGALS1
16integument phenotypeMP:00107718.3PIK3CG, RELA, BRAF, MYC, PARP1, BCL2
17digestive/alimentary phenotypeMP:00053817.6BRAF, VEGFA, MYC, BMI1, BCL2, CDKN1A
18reproductive system phenotypeMP:00053897.5PIK3CA, BRDT, VEGFA, KHDRBS1, CDKN1B, CD44
19vision/eye phenotypeMP:00053916.6PIK3CA, NCAM1, RELA, SELE, BRAF, VEGFA
20muscle phenotypeMP:00053695.3PIK3CA, PIK3CG, RELA, BRAF, VEGFA, MYC
21cardiovascular system phenotypeMP:00053854.8PIK3CA, PIK3CG, RELA, SELE, BRAF, VEGFA
22homeostasis/metabolism phenotypeMP:00053764.8PIK3CA, PIK3CG, RELA, VTN, SELE, BRAF
23hematopoietic system phenotypeMP:0005397INFPCNA, BRAF, BMI1, BCL2, CHEK2, YES1
24growth/size phenotypeMP:0005378INFPIK3CA, PIK3CG, RELA, SELE, BRAF, VCAM1
25tumorigenesisMP:0002006INFPIK3CA, BRAF, MYC, BMI1, KHDRBS1, BCL2
26immune system phenotypeMP:0005387INFBRAF, BMI1, KDR, SDC1, LGALS1, CHEK2
27behavior/neurological phenotypeMP:0005386INFPIK3CA, NCAM1, SELE, BRAF, BMI1, KHDRBS1
28mortality/agingMP:0010768INFPIK3CA, NCAM1, RELA, SELE, BRAF, VEGFA
29cellular phenotypeMP:0005384INFPIK3CA, PIK3CG, NCAM1, RELA, PCNA, SELE

Publications for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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35PubMed
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Articles related to squamous cell carcinoma of the head and neck:

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idTitleAuthorsYearAffiliating Genes
1Reduced expression of DNA repair genes (XRCC1, XPD, a nd OGG1) in squamous cell carcinoma of head and neck in North India. (22081374)Kumar A.... Khandelwal S.2012ERCC2, OGG1, XRCC1
2Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck. (21656578)Yu H.... Wei Q.2011MDM2
3Association of epidermal growth factor receptor polym orphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. (20028750)Klinghammer K.... Tinhofer I.2010EGFR
4Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. (19201650)Cohen E.E.... Vokes E.E.2009EGFR
5Effect of chemokine receptor 7 small interfering RNA on proliferation and invasion of squamous cell carcinoma of head and neck (19489250)Zhao Z.J.... Sun C.F.2009CCR7
6Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. (17785763)Bernier J.... Ang K.K.2008EGFR
7Antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck. (18025070)Thomas S.M.... Zamboni W.C.2008EGFR
8Prognostic value of 99mTc-HYNIC annexin-V imaging in squamous cell carcinoma of the head and neck. (17906858)Loose D.... Van De Wiele C.2008ANXA5
9The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. (17975141)Strauss L.... Whiteside T.L.2007CD4, IL2RA, FOXP3
10Detection of the status of tumour-infiltrating CD4+ T-cell subpopulations in squamous cell carcinoma of the head and neck (HNSCC) using real-time RT-PCR detection of CD4 mRNA. (17235436)Smerkolj S.... Glavac D.2007CD4
11Differential activity of sulindac metabolites against squamous cell carcinoma of the head and neck is mediated by p21waf1/cip1 induc tion and cell cycle inhibition. (17172818)Bock J.M.... Trask D.K.2007TP53, CASP3, PPARG
12Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. (17538161)Vermorken J.B.... Baselga J.2007EGF
13Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck. (17294448)Ito D.... DeLeo A.B.2007TP53
14P53 gene mutations in surgical margins and primary tumor tissues of patients with squamous cell carcinoma of the head and neck. (17557566)Tunca B.... Egeli U.2007TP53
15Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck. (17693666)Chen K.... Wei Q.2007TP53, BCL2, BAX
16Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8+ T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck. (17974998)Visus C.... DeLeo A.B.2007ALDH1A1
17EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. (16615113)Masood R.... Gill P.S.2006CASP8, EPHB4
18Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck. (17000697)Zhang Z.... Wei Q.2006FAS, FASLG
19p53, p63 and p73 expression in squamous cell carcinomas of the head and neck and their response to cisplatin exposure. (15608418)Gwosdz C.... Bier H.2005TP53, TP63, TP73
20The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. (15734975)Peters E.S.... Kelsey K.T.2005ADH1C
21Opioid growth factor enhances tumor growth inhibition and increases the survival of paclitaxel-treated mice with squamous cell carcinoma of the head and neck. (15791460)Jaglowski J.R.... McLaughlin P.J.2005PENK, OGFR
22Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis. (16006999)Zhang Z.... Wei Q.2005SHMT1
23Ki67, p53 and cyclin D1 in the squamous cell carcinoma of head and neck (15603389)GolusiA8ski W.... KA8osin J.2004TP53, CCND1
24Phase II trial of cisplatin and capecitabine in patients with squamous cell carcinoma of the head and neck, and correlative study of angiogenic factors. (15597103)Hitt R.... CortAcs-Funes H.2004TYMP
25Complex p63 mRNA isoform expression patterns in squamous cell carcinoma of the head and neck. (15201986)Thurfjell N.... Nylander K.2004TP63
26Simultaneously targeting epidermal growth factor rece ptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. (15355926)Chen Z.... Shin D.M.2004PTGS2
27Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck. (11948487)Weber A.... Tannapfel A.2002TP53, TP63, TP73
28Hypercalcemia associated with parathyroid hormone-related protein at the terminal stage of uncomplicated squamous cell carcinoma in the head and neck region. (11774403)Fujikawa M.... Fujishima M.2002PTHLH
29Cyclin D1 overexpression versus response to induction chemotherapy in squamous cell carcinoma of the head and neck--preliminary report. (11504311)Akervall J.... Wennerberg J.2001CCND1
30Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck. (11327540)Strojan P.... Skrk J.2001CTSB, CSTA
31Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck. (11255261)Poi M.J.... Weghorst C.M.2001CDKN2A
32Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus. (11401316)Snaddon J.... Fulton R.2001PTEN
33c-erbB-2 oncoprotein is overexpressed in poorly vascularised squamous cell carcinomas of the head and neck, but is not associated with response to cytotoxic therapy or survival. (10810387)Giatromanolaki A.... Fountzilas G.2000ERBB2
34The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck. (11016683)Nylander K.... Hall P.A.2000TP53
35EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. (10955801)Rodrigo J.P.... Suarez C.2000CCND1, CTTN
36Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. (10213212)Sauter E.R.... Herlyn M.1999VEGFA
37Expression of collagenase-3 (MMP-13) by tumor cells in squamous cell carcinomas of the head and neck. (10026851)KAohAori V.M.... Saarialho-Kere U.1998MMP13
38Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. (9796972)Matthias C.... Hoban P.R.1998CCND1
39Changes of mutant-type p53 expression in squamous cell carcinoma of the head and neck during radiation therapy and its clinical significance: comparison of an immunohistochemical method and PCR-SSCP assay. (9683807)Ogawa Y.... Kishimoto S.1998TP53
40Inhibition of transforming growth factor alpha stimulation of human squamous cell carcinoma of the head and neck with anti-TGF-alpha antibodies and tyrphostin. (9416416)Solorzano C.C.... MacKay S.L.1997TGFA
41Overexpression of cyclin D1 indicates a poor prognosis in squamous cell carcinoma of the head and neck. (9158396)Michalides R.J.... Balm A.J.1997TP53, CCND1
42PCNA, Ki-67, p53, bcl-2 and prognosis in intraoral squamous cell carcinoma of the head and neck. (9313825)Nylander K.... Roos G.1997BCL2, PCNA
43Correlated expression of glutathione S-transferase-pi and c-Jun or other oncogene products in human squamous cell carcinomas of the head and neck: relevance to relapse after radiation therapy. (9119742)Miura K.... Tsuchida S.1997HRAS, GSTP1, MYC
44Expression of CD44 splice variants in squamous epithelia and squamous cell carcinomas of the head and neck. (8691348)Herold-Mende C.... ZAPller M.1996CD44
45IL-1 and TNF-alpha but no IL-2 expression is found in squamous cell carcinomas of the head and neck by RT-PCR. (8820364)Knerer B.... Kornfehl J.1996IL4
46Loss of heterozygosity and mutation analysis of the p16 (9p21) and p53 (17p13) genes in squamous cell carcinoma of the head and neck. (9816078)GonzA!lez M.V.... Coto E.1995TP53, CDKN2A
47Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. (7854378)Brennan J.A.... Sidransky D.1995TP53
48Epidermal growth factor receptor expression by human squamous cell carcinomas of the head and neck, cell lines and xenografts. (8080726)Stanton P.... Hendler F.J.1994EGFR
49Human cytotoxic T-cell lines with restricted specificity for squamous cell carcinoma of the head and neck. (8443824)Yasumura S.... Whiteside T.L.1993IFNG
50C-erbB-2 expression in squamous cell carcinoma of the head and neck. (1377893)Field J.K.... Stell P.M.1992ERBB2

Expression for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Pathways for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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10EMD Millipore, 41Thomson Reuters, 36QIAGEN, 3Cell Signaling Technology, 20KEGG
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Pathways related to squamous cell carcinoma of the head and neck according to GeneDecks:

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idPathwayScoreTop Affiliating Genes
1Transcription P53 signaling pathway1010.7RELA, VEGFA, CDKN2A, APEX1, TP53
2Signal transduction_PTEN pathway4110.6PCNA, ITGB1, IGF1R, CASP9
3Actin-Based Motility by Rho Family GTPases3610.5ITGAV, ITGB4, FGF4, FGF7, IL2, OGFR
4Signal transduction_AKT signaling4110.1PIK3CA, RELA, PCNA, MYC, BAX, MTOR
5Transcription_P53 signaling pathway4110.1RELA, VEGFA, KDR, BCL2, XPC, CDKN1A
6Tyrosine Kinases / Adaptors310.0VEGFC, KDR, YES1, FLT1, FLT4, FGF1
7Telomerase Components in Cell Signaling3610.0VEGFC, MYC, KDR, FLT1, FLT4, FGF1
8Colorectal cancer209.8PIK3CG, BRAF, FOS, CASP9, TGFB1, TGFB2
9eNOS Signaling369.8FLT4, FGF1, FGF4, FGF7, IL2, IL3
10Regulation of eIF4 and p70S6K369.7VEGFC, BAX, CD2, CD4, ITGB1, FGF1
11ERK5 Signaling369.6VEGFC, MYC, KDR, FOS, FLT1, FLT4
12Paxillin Interactions369.5VEGFC, KDR, ITGAV, ITGB1, ITGB4, FLT1
13eIF2 Pathway369.5BRAF, VEGFC, FLT4, FGF2, FGF4, FGF7
14PTEN Pathway369.5BRAF, VEGFC, KDR, ITGB4, FLT1, FLT4
15JNK Pathway369.4KDR, BCL2, BAX, JUN, CD2, CD4
16Melanoma209.3PIK3CA, PIK3CG, BRAF, CDKN1A, CDKN2A, CDH1
17Development VEGF-family signaling109.2PIK3CA, VTN, VEGFC, KDR, ITGAV, ITGB1
18Development_EGFR signaling pathway419.2PIK3CA, MYC, JUN, MMP2, MMP9, FOS
19Glioma209.1PIK3CA, PIK3CG, BRAF, MTOR, CDKN1A, CDKN2A
20Small cell lung cancer209.1PIK3CA, PIK3CG, RELA, MYC, BCL2, CDKN1B
21Endometrial cancer209.1PIK3CA, PIK3CG, BRAF, MYC, CDH1, MLH1
22DHA Signaling369.0VEGFC, KDR, BCL2, BAX, FLT1, FLT4
23PPAR Pathway369.0VEGFC, ITGAV, ITGB1, ITGB4, FLT1, FLT4
24Development_VEGF-family signaling418.9PIK3CA, VTN, VEGFA, VEGFC, KDR, JUN
25Mitochondrial Apoptosis368.9VEGFC, KDR, BCL2, CHEK2, BAX, CDKN2A
26Bladder cancer208.9BRAF, VEGFA, VEGFC, MYC, CDKN1A, CDKN2A
27Angiogenesis38.8VEGFC, KDR, ITGAV, ITGB1, MMP2, MMP7
28Chronic myeloid leukemia208.7PIK3CA, PIK3CG, RELA, BRAF, MYC, CDKN1A
29Immune response MIF-mediated glucocorticoid regulation108.6RELA, VCAM1, JUN, MMP1, FOS, MIF
30Activation of PKA through GPCR368.5BRAF, VEGFC, KDR, FLT1, FLT4, FGF1
31ILK Signaling368.5VEGFC, KDR, JUN, CDH1, CDH15, ITGAV
32Ras Pathway368.5BRAF, VEGFC, KDR, JUN, ITGAV, ITGB1
33PEDF Induced Signaling368.4RELA, BRAF, BCL2, BAX, CD2, FOS
34Endothelin-1 Signaling Pathway368.4BRAF, MYC, CD2, FLT1, FLT4, IL10
35Prostate cancer208.3PIK3CA, PIK3CG, RELA, BRAF, BCL2, MTOR
36MIF Regulation of Innate Immune Cells368.3BCL2, BAX, JUN, CD2, FOS, MIF
37PAK Pathway368.3VEGFC, KDR, BCL2, BAX, CD2, FLT1
38Renin-Angiotensin Pathway368.3VEGFC, VCAM1, KDR, JUN, FOS, FLT1
39Nanog in Mammalian ESC Pluripotency368.1BRAF, VEGFC, KDR, FLT1, FLT4, FGF1
40Rac1 Pathway368.1KDR, JUN, ITGAV, ITGB1, ITGB4, FLT4
41Focal adhesion208.1PIK3CA, PIK3CG, VTN, BRAF, VEGFC, KDR
42p38 Signaling368.0VEGFC, KDR, BCL2, BAX, CD2, CD4
43Colorectal Cancer Metastasis367.7BRAF, MYC, BAX, CDKN1A, CDH1, MMP1
44Phospholipase-C Pathway367.6VEGFC, KDR, ITGAV, ITGB1, ITGB4, FLT1
45MAPK Family Pathway367.6BRAF, VEGFC, KDR, BCL2, BAX, JUN
46Rap1 Pathway367.5BRAF, VEGFC, ITGAV, ITGB1, ITGB4, FGF1
47Molecular Mechanisms of Cancer367.3PIK3CG, VEGFC, MYC, KDR, BCL2, CHEK2
48ERK Signaling367.1BRAF, VEGFC, MYC, CD2, ITGAV, ITGB1
49JAK-STAT Pathway366.5VEGFC, MYC, KDR, BCL2, UBE2I, BAX
50Pathways in cancer206.4PIK3CA, PIK3CG, RELA, VEGFA, VEGFC, MYC

Compounds for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
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Compounds related to squamous cell carcinoma of the head and neck according to GeneDecks:

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idCompoundScoreTop Affiliating Genes
1lysine32 11.1RELA, UBE2I, CD58, CDKN1B, IVL, CCNB1
2gold32 10.7BRAF, RAD51, MUC16, CEACAM3, CDKN2A, CD9
3p00332 10.6CHI3L1, MTRR, XRCC3, CDKN1B, CD44, CDH1
4fibrinogen32 10.5VTN, SELE, VCAM1, ZFYVE9, CEACAM3, CD9
5nocodazole32 42 9 9 13.4VTN, CHEK2, CDKN1A, CDH1, FASLG, CCNB1
6sp 60012532 42 11.4PIK3CG, VCAM1, CDKN1A, MMP1, MMP13, FGF7
7ganciclovir32 9 9 12.1KDR, CEACAM3, CD58, CD9, IL2, IL4
8dopamine32 9 18 9 13.1PIK3CA, NCAM1, SELE, MTHFR, CDKN2A, MMP9
9eb 108932 9.9PCNA, PARP1, BCL2, BAX, CDKN1A, CDKN1B
10mitomycin c32 9.9PCNA, VCAM1, RAD51, XRCC3, CD58, MGMT
11chloramphenicol32 9 9 11.8SELE, MYC, JUN, CDKN2A, CD4, CD44
12ceramide32 9.8PIK3CA, LGALS1, CDKN1B, MCL1, ANXA5, MAPK3
13roscovitine32 9.8PIK3CG, PCNA, PARP1, MCL1, MAPK3, CCNB1
14arginine32 9.8PIK3CA, VTN, BRAF, RAD51, KHDRBS1, LGALS1
15atp32 9.7PIK3CA, NCAM1, VTN, BRAF, RAD51, KHDRBS1
16p00232 9.7BRAF, MTHFR, XRCC1, CD44, CD9, CDH1
17retinoid32 9.6MYC, BCL2, LGALS1, BAX, JUN, CDKN1A
18lovastatin32 42 9 9 12.5CDKN1A, CDKN1B, CDKN2A, MMP2, FASLG, ANXA5
19hoechst 3334232 9.5PCNA, PARP1, BCL2, BAX, CDKN1A, FAS
20indole-3-carbinol32 9.4PARP1, BCL2, BAX, CDKN1A, CDKN1B, CDH1
21phorbol32 9.4MYC, JUN, CDKN1A, CD4, MMP1, MMP2
22superoxide32 18 10.4PIK3CA, VCAM1, LGALS1, MTR, MLH1, FLT1
23cholesterol32 9 18 9 12.4PIK3CA, VTN, SELE, VCAM1, MTHFR, CEACAM3
24alanine32 9.3NCAM1, VTN, PCNA, SELE, BRAF, VCAM1
25agar32 9.3PIK3CA, BRAF, LGALS1, CDKN1B, CDKN2A, CDH1
26betacarotene32 9.2PCNA, MTHFR, XRCC1, IVL, MMP1, GSTM1
27phenethyl isothiocyanate32 9.1MYC, PARP1, BCL2, BAX, JUN, GSTP1
28oxygen32 18 10.0PARP1, BCL2, LGALS1, CHEK2, BAX, MTR
29sorafenib32 9 9 11.0BRAF, VEGFA, KDR, MTOR, FLT4, FGF1
30vinblastine32 9 9 10.9KDR, BCL2, BAX, JUN, CDH1, ITGB1
31camptothecin32 42 9 9 11.9PIK3CG, PCNA, MYC, RAD51, PARP1, KDR
32mg 13232 42 9.9PIK3CG, PCNA, MYC, PARP1, KDR, BAX
33aspirin32 34 18 10.7VTN, PCNA, SELE, MTHFR, CD9, CDH1
34ciglitazone32 8.7PARP1, BAX, JUN, CDKN1A, CDKN1B, MMP2
35lactacystin32 8.6PIK3CG, SELE, MYC, PARP1, BCL2, JUN
36ns 39832 42 9.6PIK3CG, PCNA, PARP1, CDKN1B, MMP1, FGF2
37adriamycin32 8.6MYC, BCL2, CHEK2, BAX, CEACAM3, CDKN1A
38vitamin e succinate32 8.5VCAM1, MYC, PARP1, BCL2, BAX, JUN
39cysteine32 8.5VTN, PCNA, PARP1, KDR, LGALS1, UBE2I
40prednisolone32 9 9 10.4VCAM1, MYC, CD44, MMP1, MMP13, MMP2
41cytochalasin d32 42 9.3PIK3CG, VTN, SELE, VCAM1, XPC, CD44
42adenylate32 8.2PIK3CA, PIK3CG, SELE, VCAM1, CD44, CDH1
43rosiglitazone32 9 18 9 11.1PIK3CA, PIK3CG, SELE, VCAM1, JUN, CDKN1A
44troglitazone32 42 9 9 11.1PIK3CG, SELE, VCAM1, BCL2, BAX, JUN
45gm-csf32 8.0VEGFA, IL10, IL2, IL3, IL4, IL5
46sb 20358032 42 8.9SELE, BRAF, VEGFA, VCAM1, PARP1, BCL2
47lactate32 7.8PIK3CA, NCAM1, VTN, PCNA, SELE, VCAM1
48celecoxib32 42 34 9 18 9 12.6PIK3CG, PCNA, VEGFA, PARP1, KDR, BCL2
49matrigel32 7.4PIK3CA, PIK3CG, NCAM1, VTN, SELE, BRAF
50actinomycin d32 5.4PIK3CA, PIK3CG, SELE, VEGFA, MYC, PARP1

GO Terms for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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12Gene Ontology
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Cellular components related to squamous cell carcinoma of the head and neck according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.8FGF1, MMP11, VEGFA, LGALS1, CHI3L1, MMP1
2caveolaGO:0059019.3SELE, FASLG, MAPK3, MAPK1, F2R, PTGS2
3external side of plasma membraneGO:0098979.2IL4, FASLG, FAS, ANXA5, CCR7, CTSB
4nucleoplasmGO:0056549.1TP53, GNL3, CCND1, CCNA2, CCNB1, MAPK1
5extracellular regionGO:0055768.5FAS, ANGPT2, ANGPT1, IFNA2, IFNG, F2R
6cytoplasmGO:0057378.4ANXA5, FLT1, GSTP1, MKI67, FOXP3, IVL
7cell surfaceGO:0099868.3ITGAV, CDH1, CD44, LGALS1, VCAM1, ITGB1
8extracellular spaceGO:0056157.6MMP9, FLT1, MIF, FGF1, FGF2, FGF7
9plasma membraneGO:0058867.5PDGFRA, PDPN, RHOC, EGF, NOS3, PLAU
10cytosolGO:0058297.4PLK1, NOS2, NOS3, NFKB1, RHOC, NQO1
11nucleusGO:005634INFANGPT2, FAT2, TP53BP1, TP63, FAS, TP73

Biological processes related to squamous cell carcinoma of the head and neck according to GeneDecks:

(show top 50)    (show all 58)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:00018610.8F2R
2cell proliferationGO:00828310.8ISG20, MKI67, ERBB2, ILK, TGFB2, TGFA
3collagen catabolic processGO:03057410.8MMP7, MMP11, MMP13, MMP2, MMP3, MMP10
4extracellular matrix disassemblyGO:02261710.7MMP1, MMP3, MMP11, MMP10, MMP9, MMP7
5response to DNA damage stimulusGO:00697410.7MAPK3, CDKN1A, BAX, CHEK2, BCL2, MYC
6positive regulation of ERK1 and ERK2 cascadeGO:07037410.7MAPK3, CCR7, F2R, HRAS, PDGFRA, FLT4
7positive regulation of fibroblast proliferationGO:04814610.6E2F1, PDGFRA, MIF, JUN, BMI1, MYC
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.5FASLG, CDKN2A, CDKN1B, EIF2AK3, BAX, FAS
9cell migration involved in sprouting angiogenesisGO:00204210.5EPHB4, EFNB2, FGF2, VEGFA, ITGB1, KDR
10DNA repairGO:00628110.5APEX1, ERCC4, XRCC1, XRCC3, XPC, MGMT
11positive regulation of neuron apoptotic processGO:04352510.5BAX, CASP3, RHOC, NQO1, FASLG, TGFB2
12induction of apoptosis by intracellular signalsGO:00862910.4MYC, BAX, CDKN1A, CASP3, CASP8, CASP9
13xenobiotic metabolic processGO:00680510.3ADH7, ADH1C, ADH1B, NQO1, CYP2D6, PTGS1
14release of cytochrome c from mitochondriaGO:00183610.3BAX, BCL2, JUN, MYC, CASP3, TP53
15protein autophosphorylationGO:04677710.3EPHB4, KDR, CHEK2, MTOR, FLT1, CSNK2A1
16positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.3ANGPT1, MTOR, CD4, VTN, VEGFA, CD44
17response to ethanolGO:04547110.2IL4, BCL2, MMP9, MGMT, CASP8, CTSB
18positive regulation of cell divisionGO:05178110.2VEGFC, TGFB1, FGF3, TGFA, VEGFA, TGFB2
19neuron apoptotic processGO:05140210.1FAS, TP63, TP53, ERBB3, CASP3, BAX
20positive regulation of epithelial cell proliferationGO:05067910.1TGFB1, NME1, HRAS, FGF1, TGFA, EGFR
21response to radiationGO:00931410.1ANGPT2, MMP9, KRT13, TGFB2, OGG1, BCL2
22phosphatidylinositol-mediated signalingGO:04801510.0CASP9, TYMS, PTEN, ERBB2, IGF1R, TOP2A
23positive regulation of DNA replicationGO:0457409.9EGFR, HRAS, IGF1R, IL3, JUN, CSF2
24cell cycle arrestGO:0070509.8TGFB2, CDKN2A, CDKN1A, KHDRBS1, MYC, CDKN1B
25leukocyte migrationGO:0509009.7ANGPT1, HRAS, SRC, ANGPT2, ITGB1, CD2
26fibroblast growth factor receptor signaling pathwayGO:0085439.7MAPK3, FGF1, MAPK1, FGF7, FGF4, FGF3
27positive regulation of cell adhesionGO:0457859.7CCR7, VEGFA, ITGAV, FGF1, IFNG, ERBB2
28response to hypoxiaGO:0016669.6TGFB2, VCAM1, TGFB1, RHOC, BCL2, XRCC1
29positive regulation of peptidyl-serine phosphorylationGO:0331389.4TGFB1, MIF, VEGFA, CD44, BCL2, BRAF
30positive regulation of cell migrationGO:0303359.4ITGAV, KDR, VEGFA, ITGB1, FLT1, FGF1
31induction of apoptosisGO:0069179.4PTEN, TGFB2, TGFB1, BAX, CDKN1B, FASLG
32angiogenesisGO:0015259.2EPHB4, EPHA2, SYK, MMP2, ITGAV, JUN
33signal transductionGO:0071659.2ERBB2, ERBB3, HRAS, IGF1R, CCR6, MAPK1
34positive regulation of MAP kinase activityGO:0434069.2VEGFA, TGFB1, EGFR, EGF, ERBB2, ILK
35innate immune responseGO:0450879.1ART1, MIF, FOS, CD4, JUN, BCL2
36nerve growth factor receptor signaling pathwayGO:0480119.1STAT3, BRAF, RELA, NFKB1, PIK3CA, MAPK1
37apoptotic processGO:0069159.1TP63, CLPTM1L, BCL2, LGALS1, FAS, CASP8
38anti-apoptosisGO:0069169.1IL10, GSTP1, BCL2, BRAF, RELA, PIK3CA
39negative regulation of apoptotic processGO:0430669.1CDKN1B, PLK1, KRT18, EGFR, TGFB2, CSF2
40inflammatory responseGO:0069549.0CCR7, F2R, TP73, PTGS2, NFKB1, PDPN
41virus-host interactionGO:0190488.9MAPK3, MDM2, IL2RB, MMP1, MAPK1, ITGB1
42agingGO:0075688.8EPO, TGFB2, TOP2A, NOS3, ERCC2, FAS
43positive regulation of transcription from RNA polymerase II promoterGO:0459448.7STAT3, FOXP3, CDKN2A, RELA, JUN, MYC
44epidermal growth factor receptor signaling pathwayGO:0071738.6PIK3CA, PTEN, SRC, EGF, EGFR, TGFA
45positive regulation of cell proliferationGO:0082848.3ITGAV, FLT4, EPO, CSF3, CSF2, CSF1
46blood coagulationGO:0075967.6ITGAV, TP53, HRAS, SRC, PLAU, NOS2
47response to drugGO:0424937.6IFNG, VEGFC, CTNNB1, TGFBR2, DNMT3B, STAT3
48negative regulation of cell proliferationGO:008285INF, FOXP3, CDKN1B, ITGB1, CD9, CDKN2A
49positive regulation of transcription, DNA-dependentGO:045893INFFGF2, FOXP3, , TP73, MYC, FOS
50positive regulation of apoptotic processGO:043065INFITGB1, PTGS2, NOS3, TOP2A, CTNNB1, TGFB2

Molecular functions related to squamous cell carcinoma of the head and neck according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:01990110.5RELA, CHEK2, STAT3, PLK1, PTEN, SYK
2transmembrane receptor protein tyrosine kinase activityGO:00471410.4ERBB3, EPHB4, EPHA2, EGFR, PDGFRA, ERBB2
3identical protein bindingGO:0428029.8NME1, PCNA, BCL2, RELA, EGFR, TP73
4protein homodimerization activityGO:0428039.0PDGFRA, NOS2, PTGS2, TERT, FOXP3, SHMT1
5enzyme bindingGO:0198998.9TGFB1, TOP2A, PPARG, YES1, EGFR, CTNNB1
6cytokine activityGO:0051258.7TGFB2, IFNG, IFNA2, FASLG, IL5, IL4
7growth factor activityGO:0080838.5CSF3, IL2, IL10, FGF7, FGF4, FGF3
8ATP bindingGO:0055248.2PIK3CA, ERCC2, ERBB2, TP53, SRC, PLK1
9protein bindingGO:0055154.4KRT19, PPP1R15A, CTSB, CTNNB1, CTTN, SRC

Sources for Squamous Cell Carcinoma of the Head and Neck

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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