HNSCC
MCID: SQM007
MIFTS: 66

Squamous Cell Carcinoma of the Head and Neck (HNSCC) malady

Genetic diseases, Rare diseases, Cancer diseases categories

Summaries for Squamous Cell Carcinoma of the Head and Neck

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MedlinePlus:33 Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes in the neck. most begin in the moist tissues that line the mouth, nose and throat. symptoms include a lump or sore that does not heal a sore throat that does not go away trouble swallowing a change or hoarseness in the voice using tobacco or alcohol increases your risk. in fact, 85 percent of head and neck cancers are linked to tobacco use, including smoking and smokeless tobacco. if found early, these cancers are often curable. treatments may include surgery, radiation therapy, chemotherapy or a combination. treatments can affect eating, speaking or even breathing, so patients may need rehabilitation. nih: national cancer institute

MalaCards based summary: Squamous Cell Carcinoma of the Head and Neck, also known as carcinoma, squamous cell of head and neck, is related to squamous cell carcinoma, head and neck, somatic and colorectal cancer, and has symptoms including autosomal recessive inheritanceand squamous cell carcinoma. An important gene associated with Squamous Cell Carcinoma of the Head and Neck is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are NF-KappaB Family Pathway and p53 signaling pathway. The compounds panitumumab and gw9662 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, salivary gland and t cells, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:9 A head and neck carcinoma that has material basis in squamous cells that line the moist, mucosal surfaces inside the head and neck.

Wikipedia:64 Head and neck cancer refers to a group of biologically similar cancers that start in the lip, oral... more...

Description from OMIM:46 275355

Aliases & Classifications for Squamous Cell Carcinoma of the Head and Neck

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Sources:
31LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 42NIH Rare Diseases, 23GTR, 46OMIM, 44Novoseek, 48Orphanet, 33MedlinePlus, 61UMLS, 34MeSH, 39NCIt, 35MESH via Orphanet, 62UMLS via Orphanet
See all sources

Squamous Cell Carcinoma of the Head and Neck, Aliases & Descriptions:

Name: Squamous Cell Carcinoma of the Head and Neck 31 9 42
Carcinoma, Squamous Cell of Head and Neck 42 23 61
Head and Neck Squamous Cell Carcinoma 9 42 48
Hnscc 42 44 48
Squamous Cell Carcinoma, Head and Neck 10 46
Carcinoma of the Neck 9 61
 
Head and Neck Cancer 33 61
Neck Cancer 44 61
Squamous Cell Carcinomas of Head and Neck 9
Squamous Cell Carcinoma of Head and Neck 48
Carcinoma of the Head and Neck 9
Head and Neck Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
head and neck squamous cell carcinoma:
Prevalence: 1-5/10000; Age of onset: Variable


External Ids:

Disease Ontology9 DOID:5520, DOID:1542
OMIM46 275355
MeSH34 C535575
MESH via Orphanet35 C535575
UMLS via Orphanet62 C1168401

Related Diseases for Squamous Cell Carcinoma of the Head and Neck

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Diseases related to Squamous Cell Carcinoma of the Head and Neck via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma, head and neck, somatic31.6PTEN, ING1
2colorectal cancer31.2TNFRSF10B, ING1, PTEN, EGFR
3melanoma30.9TNFRSF10B, CCR7, PTEN, ERCC2, ING1
4breast cancer30.8ERCC2, PTEN, CSTA, EGFR
5lung cancer30.8CSTA, ING1, EGFR, TNFRSF10B, ERCC2
6non-small cell lung carcinoma30.6TNFRSF10B, PTEN, EGFR, CSTA, ERCC2, CCR7
7prostate cancer30.6TNFRSF10B, EGFR, ERCC2, CSTA, PTEN
8adenocarcinoma30.5CSTA, PENK, ING1, TNFRSF10B, EGFR, PTEN
9pancreatic cancer30.0EGFR, OGFR, CCR7, PENK, TNFRSF10B
10ovarian cancer30.0CCR7, PTEN, TNFRSF10B, EGFR, ERCC2
11basaloid squamous cell carcinoma11.0
12cervicitis10.9
13endotheliitis10.9
14merkel cell carcinoma10.8
15papilloma10.8
16dermatitis10.7
17hypoxia10.7
18verrucous carcinoma10.7
19neuroendocrine carcinoma10.6
20ataxia telangiectasia10.6
21leukoplakia10.6
22ataxia10.6
23adenoiditis10.6
24esophagitis10.6
25prostatitis10.6
26large cell neuroendocrine carcinoma10.6
27small cell carcinoma10.6
28adenosquamous carcinoma10.6
29spindle cell carcinoma10.6
30gemistocytic astrocytoma10.6PTEN
31leukemia10.5
32periodontitis10.5
33retinoblastoma10.5
34basal cell carcinoma10.5
35gliosarcoma10.5PTEN
36acne10.4
37esophageal cancer10.4
38hepatitis10.4
39hepatitis c10.4
40myelitis10.4
41adenoid squamous cell carcinoma10.4
42hypercalcemia10.4
43nasopharyngitis10.4
44herpes simplex10.4
45leiomyosarcoma10.4
46prostate adenocarcinoma10.4
47thyroiditis10.4
48mutagen sensitivity10.4
49radiation induced cancer10.4
50syndrome of inappropriate antidiuretic hormone10.4

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma of the Head and Neck:



Diseases related to squamous cell carcinoma of the head and neck

Symptoms for Squamous Cell Carcinoma of the Head and Neck

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Symptoms by clinical synopsis from OMIM:

275355

Clinical features from OMIM:

275355

HPO human phenotypes related to Squamous Cell Carcinoma of the Head and Neck:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 squamous cell carcinoma HP:0002860

Drugs & Therapeutics for Squamous Cell Carcinoma of the Head and Neck

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Drug clinical trials:

Search ClinicalTrials for Squamous Cell Carcinoma of the Head and Neck

Search NIH Clinical Center for Squamous Cell Carcinoma of the Head and Neck

Genetic Tests for Squamous Cell Carcinoma of the Head and Neck

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Genetic tests related to Squamous Cell Carcinoma of the Head and Neck:

id Genetic test Affiliating Genes
1 Squamous Cell Carcinoma of the Head and Neck23

Anatomical Context for Squamous Cell Carcinoma of the Head and Neck

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MalaCards organs/tissues related to Squamous Cell Carcinoma of the Head and Neck:

32
Lymph node, Salivary gland, T cells, Endothelial, Skin, Lung, Breast, Bone, Prostate, Testes, Bone marrow, Thyroid, Testis, Pituitary

Animal Models for Squamous Cell Carcinoma of the Head and Neck or affiliated genes

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MGI Mouse Phenotypes related to Squamous Cell Carcinoma of the Head and Neck:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5EGFR, ING1, PMAIP1, TNFRSF10B, PTEN, ERCC2
2MP:00053979.5PMAIP1, TNFRSF10B, PTEN, CCR7, ERCC2, EGFR
3MP:00053879.0DEFB103A, ING1, PMAIP1, TNFRSF10B, PTEN, CCR7

Publications for Squamous Cell Carcinoma of the Head and Neck

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Articles related to Squamous Cell Carcinoma of the Head and Neck:

(show top 50)    (show all 757)
idTitleAuthorsYear
1
Risk factors for and pre-medications to prevent cetuximab-induced infusion reactions in patients with squamous cell carcinoma of the head and neck. (25037161)
2014
2
A phase II trial of biweekly gemcitabine and paclitaxel with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN): SWOG study S0329. (24166832)
2013
3
A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck. (22371453)
2012
4
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck. (22548841)
2012
5
Selective neck dissection in node-positive squamous cell carcinoma of the head and neck. (22517013)
2012
6
Bovine papillomavirus type 1 and Equus caballus papillomavirus 2 in equine squamous cell carcinoma of the head and neck in a Connemara mare. (21668491)
2012
7
Phase II Study of Gemcitabine and Docetaxel Combination in Patients with Previously Treated Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. (22655205)
2012
8
Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck. (22513208)
2012
9
XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. (21737503)
2011
10
S-1 monotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck after progression on platinum-based chemotherapy. (21980053)
2011
11
Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. (21653686)
2011
12
Metastases of squamous cell carcinoma of the head and neck show increased levels of nucleotide excision repair protein XPF in vivo that correlate with increased chemoresistance ex vivo. (20372803)
2010
13
Small atypical cervical nodes detected on sonography in patients with squamous cell carcinoma of the head and neck: probability of metastasis. (20375372)
2010
14
MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck. (20682983)
2010
15
CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neck. (20577877)
2010
16
Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response. (20309553)
2010
17
Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. (19917840)
2010
18
Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420. (20498388)
2010
19
Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. (18632233)
2009
20
Weekly docetaxel in patients with platinum-refractory metastatic or recurrent squamous cell carcinoma of the head and neck. (19381630)
2009
21
A contemporary review of indications for primary surgical care of patients with squamous cell carcinoma of the head and neck. (19718757)
2009
22
Squamous cell carcinoma of the head and neck: ESMO clinical recommendations for diagnosis, treatment and follow-up. (19454430)
2009
23
Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. (17764087)
2008
24
High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival. (17957792)
2008
25
Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. (17785763)
2008
26
Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. (18496144)
2008
27
Down-regulation of Mcl-1 with antisense technology alters the effect of various cytotoxic agents used in treatment of squamous cell carcinoma of the head and neck. (18497956)
2008
28
The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. (17975141)
2007
29
TP53 mutations and survival in squamous-cell carcinoma of the head and neck. (18094376)
2007
30
Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma of the head and neck. (17667135)
2007
31
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. (17118968)
2007
32
Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck. (17029632)
2006
33
EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. (16615113)
2006
34
Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. (16685459)
2006
35
A study of TRAIL receptors in squamous cell carcinoma of the head and neck. (15897419)
2005
36
Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck. (16322265)
2005
37
The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times. (16024113)
2005
38
Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck. (15608423)
2005
39
Combination of mutated herpes simplex virus type 1 (G207 virus) with radiation for the treatment of squamous cell carcinoma of the head and neck. (15661558)
2005
40
Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck. (15608417)
2005
41
Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration. (14654962)
2004
42
Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck. (15585623)
2004
43
Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck. (14735195)
2004
44
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. (12771142)
2003
45
Inactivation of p53 and amplification of cyclin D1 in squamous cell carcinomas of the head and neck]. (12185899)
2002
46
Human squamous cell carcinomas of the head and neck chemoattract immune suppressive CD34(+) progenitor cells. (11295465)
2001
47
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. (11710599)
2001
48
EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. (10955801)
2000
49
Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck. (9049184)
1997
50
Investigation of urinary transforming growth factor alpha levels as tumor markers in patients with advanced squamous cell carcinoma of the head and neck. (2211102)
1990

Variations for Squamous Cell Carcinoma of the Head and Neck

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UniProtKB/Swiss-Prot genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

63
id Symbol AA change Variation ID SNP ID
1ING1p.Ala335AspVAR_017420
2ING1p.Cys358SerVAR_017421
3ING1p.Asn359SerVAR_017422
4ING3p.Asp20GlyVAR_021263
5PTENp.Ala121GlyVAR_018103

Clinvar genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

7 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1NM_005228.3(EGFR): c.2327G> A (p.Arg776His)single nucleotide variantdrug responsers483352806GRCh37Chr 7, 55249029: 55249029
2EGFRNM_005228.3(EGFR): c.2471G> A (p.Gly824Asp)single nucleotide variantdrug responsers483352808GRCh38Chr 7, 55191720: 55191720
3EGFRNM_005228.3(EGFR): c.2188C> G (p.Leu730Val)single nucleotide variantdrug responsers121913434GRCh37Chr 7, 55242418: 55242418
4NM_005228.3(EGFR): c.2393T> A (p.Leu798His)single nucleotide variantdrug responsers483352807GRCh38Chr 7, 55181402: 55181402
5EGFRNM_005228.3(EGFR): c.2176G> A (p.Val726Met)single nucleotide variantdrug responsers483352805GRCh37Chr 7, 55241728: 55241728
6EGFRNM_005228.3(EGFR): c.2155G> C (p.Gly719Arg)single nucleotide variantLikely pathogenic, drug responsers28929495GRCh37Chr 7, 55241707: 55241707
7TNFRSF10BTNFRSF10B, 2-BP INSinsertionPathogenic
8PTENNM_000314.4(PTEN): c.362C> G (p.Ala121Gly)single nucleotide variantPathogenicrs121909237GRCh37Chr 10, 89692878: 89692878
9ING1NM_198217.2(ING1): c.512G> C (p.Cys171Ser)single nucleotide variantPathogenicrs121909250GRCh37Chr 13, 111372083: 111372083
10ING1NM_198217.2(ING1): c.515A> G (p.Asn172Ser)single nucleotide variantPathogenicrs121909251GRCh37Chr 13, 111372086: 111372086
11ING1NM_198217.2(ING1): c.443C> A (p.Ala148Asp)single nucleotide variantPathogenicrs121909252GRCh37Chr 13, 111372014: 111372014

Expression for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Squamous Cell Carcinoma of the Head and Neck patients vs. healthy controls: 31 (show all 223)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1MMP1matrix metallopeptidase 1 (interstitial collagenase)Head Mesenchyme+5.250.000
2TMPRSS11Btransmembrane protease, serine 11BHead Mesenchyme-4.810.000
3CRISP3cysteine-rich secretory protein 3Head Mesenchyme-4.480.000
4MALmal, T-cell differentiation proteinHead Mesenchyme-4.390.000
5INHBAinhibin, beta AHead Mesenchyme+4.130.000
6CRNNcornulinHead Mesenchyme-4.000.000
7KRT17keratin 17Head Mesenchyme+3.940.000
8KRT4keratin 4Head Mesenchyme-3.410.000
9PTHLHparathyroid hormone-like hormoneHead Mesenchyme+3.360.000
10CTHRC1collagen triple helix repeat containing 1Head Mesenchyme+3.320.000
11CLCA4chloride channel accessory 4Head Mesenchyme-3.310.000
12WDR72WD repeat domain 72Head Mesenchyme+3.230.000
13MMP10matrix metallopeptidase 10 (stromelysin 2)Head Mesenchyme+3.140.001
14TGM3transglutaminase 3Head Mesenchyme-3.080.000
15GBP1guanylate binding protein 1, interferon-inducibleHead Mesenchyme+3.060.000
16WDR66WD repeat domain 66Head Mesenchyme+2.960.000
17ISG15ISG15 ubiquitin-like modifierHead Mesenchyme+2.950.000
18MMP12matrix metallopeptidase 12 (macrophage elastase)Head Mesenchyme+2.910.000
19PADI1peptidyl arginine deiminase, type IHead Mesenchyme-2.890.000
20RHCGRh family, C glycoproteinHead Mesenchyme-2.840.001
21KRT13keratin 13Head Mesenchyme-2.820.008
22SCINscinderinHead Mesenchyme-2.770.000
23POSTNperiostin, osteoblast specific factorHead Mesenchyme+2.750.002
24SPINK7serine peptidase inhibitor, Kazal type 7 (putative)Head Mesenchyme-2.730.002
25MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Head Mesenchyme+2.710.001
26SPRR3small proline-rich protein 3Head Mesenchyme-2.680.010
27FN1fibronectin 1Head Mesenchyme+2.610.001
28PPP1R3Cprotein phosphatase 1, regulatory subunit 3CHead Mesenchyme-2.590.000
29SEMA3Csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3CHead Mesenchyme+2.580.000
30ENDOUendonuclease, polyU-specificHead Mesenchyme-2.530.000
31KRT78keratin 78Head Mesenchyme-2.450.000
32TMPRSS11Etransmembrane protease, serine 11EHead Mesenchyme-2.440.005
33CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Head Mesenchyme-2.410.001
34CRCT1cysteine-rich C-terminal 1Head Mesenchyme-2.400.011
35KRT16keratin 16Head Mesenchyme+2.380.022
36CAPN14calpain 14Head Mesenchyme-2.370.002
37IFI27interferon, alpha-inducible protein 27Head Mesenchyme+2.370.001
38COL1A2collagen, type I, alpha 2Head Mesenchyme+2.370.001
39EPPK1epiplakin 1Head Mesenchyme+2.360.000
40COL4A1collagen, type IV, alpha 1Head Mesenchyme+2.360.000
41LOC441178uncharacterized LOC441178Head Mesenchyme-2.360.000
42LUMlumicanHead Mesenchyme+2.350.002
43SPP1secreted phosphoprotein 1Head Mesenchyme+2.310.008
44GBP6guanylate binding protein family, member 6Head Mesenchyme-2.310.002
45CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Head Mesenchyme+2.300.000
46LAMC2laminin, gamma 2Head Mesenchyme+2.290.000
47XISTX inactive specific transcript (non-protein coding)Head Mesenchyme-2.290.050
48PHLDB2pleckstrin homology-like domain, family B, member 2Head Mesenchyme+2.260.000
49RBM20RNA binding motif protein 20Head Mesenchyme-2.260.000
50ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Head Mesenchyme-2.250.001
51TENM2teneurin transmembrane protein 2Head Mesenchyme+2.250.011
52IKZF2IKAROS family zinc finger 2 (Helios)Head Mesenchyme-2.230.000
53CTSCcathepsin CHead Mesenchyme+2.230.002
54LGALS1lectin, galactoside-binding, soluble, 1Head Mesenchyme+2.220.000
55SPINK5serine peptidase inhibitor, Kazal type 5Head Mesenchyme-2.220.004
56CXCL11chemokine (C-X-C motif) ligand 11Head Mesenchyme+2.220.022
57TGFBItransforming growth factor, beta-induced, 68kDaHead Mesenchyme+2.220.001
58ZIC2Zic family member 2Head Mesenchyme+2.220.002
59ODC1ornithine decarboxylase 1Head Mesenchyme+2.180.001
60LOXlysyl oxidaseHead Mesenchyme+2.180.014
61CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5Head Mesenchyme-2.180.001
62DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 60Head Mesenchyme+2.170.004
63KLF8Kruppel-like factor 8Head Mesenchyme-2.150.000
64PRSS27protease, serine 27Head Mesenchyme-2.150.001
65COL12A1collagen, type XII, alpha 1Head Mesenchyme+2.140.012
66IL8interleukin 8Head Mesenchyme+2.130.011
67COL3A1collagen, type III, alpha 1Head Mesenchyme+2.120.002
68ECM1extracellular matrix protein 1Head Mesenchyme-2.120.000
69BST2bone marrow stromal cell antigen 2Head Mesenchyme+2.120.007
70VSIG10LV-set and immunoglobulin domain containing 10 likeHead Mesenchyme-2.100.011
71MLF1myeloid leukemia factor 1Head Mesenchyme+2.090.000
72RSAD2radical S-adenosyl methionine domain containing 2Head Mesenchyme+2.090.013
73STAT1signal transducer and activator of transcription 1, 91kDaHead Mesenchyme+2.090.001
74PMEPA1prostate transmembrane protein, androgen induced 1Head Mesenchyme+2.080.002
75CXCL10chemokine (C-X-C motif) ligand 10Head Mesenchyme+2.070.016
76SPARCsecreted protein, acidic, cysteine-rich (osteonectin)Head Mesenchyme+2.070.003
77ANO1anoctamin 1, calcium activated chloride channelHead Mesenchyme+2.070.016
78CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrialHead Mesenchyme+2.060.017
79COL1A1collagen, type I, alpha 1Head Mesenchyme+2.050.001
80COL5A2collagen, type V, alpha 2Head Mesenchyme+2.050.008
81PDGFAplatelet-derived growth factor alpha polypeptideHead Mesenchyme+2.050.001
82PLAUplasminogen activator, urokinaseHead Mesenchyme+2.050.002
83MICAL2microtubule associated monooxygenase, calponin and LIM domain containing 2Head Mesenchyme+2.040.001
84TNCtenascin CHead Mesenchyme+2.030.005
85TPM1tropomyosin 1 (alpha)Head Mesenchyme+2.030.007
86HLA-Bmajor histocompatibility complex, class I, BHead Mesenchyme+2.030.004
87GPNMBglycoprotein (transmembrane) nmbHead Mesenchyme+2.030.003
88MAMDC2MAM domain containing 2Head Mesenchyme-2.020.011
89HOPXHOP homeoboxHead Mesenchyme-2.020.017
90FAM3Bfamily with sequence similarity 3, member BHead Mesenchyme-2.020.017
91IFI44Linterferon-induced protein 44-likeHead Mesenchyme+2.010.019
92SLC16A6solute carrier family 16, member 6Head Mesenchyme-2.000.002
93IFIT3interferon-induced protein with tetratricopeptide repeats 3Head Mesenchyme+1.990.012
94FMO2flavin containing monooxygenase 2 (non-functional)Head Mesenchyme-1.990.001
95ATP13A4ATPase type 13A4Head Mesenchyme-1.980.002
96IFIT1interferon-induced protein with tetratricopeptide repeats 1Head Mesenchyme+1.980.025
97HOXC6homeobox C6Head Mesenchyme+1.970.004
98VCANversicanHead Mesenchyme+1.950.007
99IFI35interferon-induced protein 35Head Mesenchyme+1.950.003
100GLIPR1GLI pathogenesis-related 1Head Mesenchyme+1.930.007
101FAM3Dfamily with sequence similarity 3, member DHead Mesenchyme-1.910.000
102CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Head Mesenchyme+1.910.021
103EPCAMepithelial cell adhesion moleculeHead Mesenchyme+1.900.026
104IFI6interferon, alpha-inducible protein 6Head Mesenchyme+1.900.004
105TMEM45Atransmembrane protein 45AHead Mesenchyme+1.890.013
106MYO1Bmyosin IBHead Mesenchyme+1.890.002
107FMO9Pflavin containing monooxygenase 9 pseudogeneHead Mesenchyme-1.890.002
108C9orf169chromosome 9 open reading frame 169Head Mesenchyme-1.880.010
109SULF1sulfatase 1Head Mesenchyme+1.880.023
110EMP1epithelial membrane protein 1Head Mesenchyme-1.870.007
111C12orf75chromosome 12 open reading frame 75Head Mesenchyme+1.860.006
112GCOM1GRINL1A complex locus 1Head Mesenchyme-1.860.000
113SCNN1Asodium channel, non-voltage-gated 1 alpha subunitHead Mesenchyme-1.860.023
114TTC9tetratricopeptide repeat domain 9Head Mesenchyme-1.860.021
115A2ML1alpha-2-macroglobulin-like 1Head Mesenchyme-1.860.032
116PROCRprotein C receptor, endothelialHead Mesenchyme+1.840.006
117SH3BGRL2SH3 domain binding glutamate-rich protein like 2Head Mesenchyme-1.840.001
118COL4A2collagen, type IV, alpha 2Head Mesenchyme+1.840.001
119ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix proteinHead Mesenchyme-1.830.019
120FTLferritin, light polypeptideHead Mesenchyme+1.830.028
121CXCL9chemokine (C-X-C motif) ligand 9Head Mesenchyme+1.820.028
122MMP7matrix metallopeptidase 7 (matrilysin, uterine)Head Mesenchyme+1.810.034
123SNX10sorting nexin 10Head Mesenchyme+1.810.005
124ACKR3atypical chemokine receptor 3Head Mesenchyme+1.810.025
125SYTL4synaptotagmin-like 4Head Mesenchyme-1.800.003
126EPB41L3erythrocyte membrane protein band 4.1-like 3Head Mesenchyme-1.800.024
127FMO1flavin containing monooxygenase 1Head Mesenchyme-1.790.003
128PLAGL1pleiomorphic adenoma gene-like 1Head Mesenchyme-1.780.035
129APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BHead Mesenchyme+1.780.024
130LAPTM4Blysosomal protein transmembrane 4 betaHead Mesenchyme+1.770.007
131FSTfollistatinHead Mesenchyme+1.770.035
132PPLperiplakinHead Mesenchyme-1.770.011
133IFI44interferon-induced protein 44Head Mesenchyme+1.770.045
134HLFhepatic leukemia factorHead Mesenchyme-1.770.001
135WARStryptophanyl-tRNA synthetaseHead Mesenchyme+1.760.005
136SORBS2sorbin and SH3 domain containing 2Head Mesenchyme-1.760.007
137ENAHenabled homolog (Drosophila)Head Mesenchyme+1.750.002
138FNDC3Bfibronectin type III domain containing 3BHead Mesenchyme+1.750.003
139NRIP1nuclear receptor interacting protein 1Head Mesenchyme+1.730.027
140COL5A1collagen, type V, alpha 1Head Mesenchyme+1.730.016
141TYMPthymidine phosphorylaseHead Mesenchyme+1.730.017
142MYLKmyosin light chain kinaseHead Mesenchyme+1.720.023
143CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Head Mesenchyme-1.720.031
144TPBGtrophoblast glycoproteinHead Mesenchyme+1.710.000
145SLC16A1solute carrier family 16 (monocarboxylate transporter), member 1Head Mesenchyme+1.710.008
146FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideHead Mesenchyme-1.700.014
147ECT2epithelial cell transforming 2Head Mesenchyme+1.700.016
148PSMB9proteasome (prosome, macropain) subunit, beta type, 9Head Mesenchyme+1.700.018
149HOXD10homeobox D10Head Mesenchyme+1.700.026
150MTHFD1Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-likeHead Mesenchyme+1.690.002
151SERPINB11serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)Head Mesenchyme-1.680.003
152SCELsciellinHead Mesenchyme-1.680.012
153SAMD5sterile alpha motif domain containing 5Head Mesenchyme-1.680.005
154CSPG4chondroitin sulfate proteoglycan 4Head Mesenchyme+1.670.022
155FEZ1fasciculation and elongation protein zeta 1 (zygin I)Head Mesenchyme+1.670.013
156PRSS23protease, serine, 23Head Mesenchyme+1.670.031
157CEACAM7carcinoembryonic antigen-related cell adhesion molecule 7Head Mesenchyme-1.670.041
158SCRN1secernin 1Head Mesenchyme+1.660.005
159ABCG1ATP-binding cassette, sub-family G (WHITE), member 1Head Mesenchyme+1.640.025
160SOX4SRY (sex determining region Y)-box 4Head Mesenchyme+1.640.016
161HPGDhydroxyprostaglandin dehydrogenase 15-(NAD)Head Mesenchyme-1.640.018
162LY6Klymphocyte antigen 6 complex, locus KHead Mesenchyme+1.640.016
163BLNKB-cell linkerHead Mesenchyme-1.630.012
164HOMER3homer homolog 3 (Drosophila)Head Mesenchyme+1.630.013
165ZBTB38zinc finger and BTB domain containing 38Head Mesenchyme+1.630.029
166DCBLD2discoidin, CUB and LCCL domain containing 2Head Mesenchyme+1.620.037
167PXDNperoxidasin homolog (Drosophila)Head Mesenchyme+1.620.044
168CAV1caveolin 1, caveolae protein, 22kDaHead Mesenchyme+1.620.038
169ADAM12ADAM metallopeptidase domain 12Head Mesenchyme+1.620.045
170SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2Head Mesenchyme+1.620.033
171CEBPBCCAAT/enhancer binding protein (C/EBP), betaHead Mesenchyme+1.610.017
172MAOBmonoamine oxidase BHead Mesenchyme-1.610.018
173ALOX12arachidonate 12-lipoxygenaseHead Mesenchyme-1.610.017
174EPSTI1epithelial stromal interaction 1 (breast)Head Mesenchyme+1.600.031
175MGLLmonoglyceride lipaseHead Mesenchyme-1.600.007
176ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDaHead Mesenchyme+1.590.009
177METmet proto-oncogeneHead Mesenchyme+1.590.031
178FMNL2formin-like 2Head Mesenchyme+1.590.021
179YBX1Y box binding protein 1Head Mesenchyme+1.580.013
180LOC100506098uncharacterized LOC100506098Head Mesenchyme-1.580.019
181GSTO1glutathione S-transferase omega 1Head Mesenchyme+1.570.030
182GOLIM4golgi integral membrane protein 4Head Mesenchyme+1.570.017
183IRS1insulin receptor substrate 1Head Mesenchyme+1.560.037
184SLC26A2solute carrier family 26 (anion exchanger), member 2Head Mesenchyme-1.560.008
185CGNL1cingulin-like 1Head Mesenchyme-1.560.029
186ALYREFAly/REF export factorHead Mesenchyme+1.550.022
187BTG1B-cell translocation gene 1, anti-proliferativeHead Mesenchyme+1.550.043
188CPEB3cytoplasmic polyadenylation element binding protein 3Head Mesenchyme-1.550.006
189TNFAIP3tumor necrosis factor, alpha-induced protein 3Head Mesenchyme+1.550.014
190MED30mediator complex subunit 30Head Mesenchyme+1.540.013
191GGTA1Pglycoprotein, alpha-galactosyltransferase 1 pseudogeneHead Mesenchyme-1.540.017
192CA13carbonic anhydrase XIIIHead Mesenchyme-1.530.038
193HAT1histone acetyltransferase 1Head Mesenchyme+1.530.048
194SIX4SIX homeobox 4Head Mesenchyme+1.520.034
195RANBP1RAN binding protein 1Head Mesenchyme+1.520.014
196GYS2glycogen synthase 2 (liver)Head Mesenchyme-1.510.012
197CYSLTR1cysteinyl leukotriene receptor 1Head Mesenchyme-1.510.016
198TP53INP2tumor protein p53 inducible nuclear protein 2Head Mesenchyme-1.510.016
199EXPH5exophilin 5Head Mesenchyme-1.510.015
200LACTB2lactamase, beta 2Head Mesenchyme+1.510.020
201FBXO45F-box protein 45Head Mesenchyme+1.500.036
202BOCBOC cell adhesion associated, oncogene regulatedHead Mesenchyme-1.480.045
203HLA-Fmajor histocompatibility complex, class I, FHead Mesenchyme+1.480.044
204PSMA7proteasome (prosome, macropain) subunit, alpha type, 7Head Mesenchyme+1.470.013
205CLIC4chloride intracellular channel 4Head Mesenchyme+1.470.033
206STK17Aserine/threonine kinase 17aHead Mesenchyme+1.460.040
207GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)Head Mesenchyme+1.450.039
208C3orf52chromosome 3 open reading frame 52Head Mesenchyme+1.440.042
209MAML3mastermind-like 3 (Drosophila)Head Mesenchyme-1.440.040
210KAT2BK(lysine) acetyltransferase 2BHead Mesenchyme-1.420.032
211ROR1receptor tyrosine kinase-like orphan receptor 1Head Mesenchyme-1.420.042
212LNX1ligand of numb-protein X 1, E3 ubiquitin protein ligaseHead Mesenchyme-1.420.039
213MEIS1Meis homeobox 1Head Mesenchyme-1.420.020
214MRPL13mitochondrial ribosomal protein L13Head Mesenchyme+1.410.034
215CXCR2chemokine (C-X-C motif) receptor 2Head Mesenchyme-1.390.034
216ZNF281zinc finger protein 281Head Mesenchyme+1.390.034
217MLECmalectinHead Mesenchyme+1.380.034
218LPCAT1lysophosphatidylcholine acyltransferase 1Head Mesenchyme+1.370.025
219C2orf54chromosome 2 open reading frame 54Head Mesenchyme-1.360.015
220NMIN-myc (and STAT) interactorHead Mesenchyme+1.360.049
221ANKRD20A11Pankyrin repeat domain 20 family, member A11, pseudogeneHead Mesenchyme-1.350.024
222STK3serine/threonine kinase 3Head Mesenchyme+1.350.048
223SASH1SAM and SH3 domain containing 1Head Mesenchyme-1.340.049

Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Search GEO for disease gene expression data for Squamous Cell Carcinoma of the Head and Neck.

Pathways for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Pathways related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0EGFR, OGFR, PENK
2
Show member pathways
DNA damage response37
9.9PMAIP1, TNFRSF10B, PTEN, TP53I3
39.9PTEN, MIR146A, MIR137, EGFR
4
Show member pathways
9.8PENK, PTEN, OGFR, EGFR
5
Show member pathways
9.8EGFR, OGFR, PTEN, PENK
6
Show member pathways
9.8PENK, TNFRSF10B, PTEN, CCR7, EGFR
79.7EGFR, TP53I3, PTEN, TNFRSF10B, PMAIP1
8
Show member pathways
9.6PENK, TNFRSF10B, PTEN, CCR7, OGFR, EGFR
9
Show member pathways
9.5PENK, PMAIP1, TNFRSF10B, PTEN, OGFR, EGFR
10
Show member pathways
9.4PENK, PMAIP1, TNFRSF10B, PTEN, CCR7, OGFR

Compounds for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Compounds related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1212.5EGFR, PTEN
2gw966244 2911.5PTEN, TNFRSF10B
3bortezomib44 50 1212.4EGFR, PTEN, TNFRSF10B
4oxaliplatin44 50 1212.3TNFRSF10B, ERCC2, EGFR
5taxane4410.3PTEN, EGFR
6mg 13244 6011.3EGFR, PTEN, TNFRSF10B
7vinorelbine44 50 1212.3ERCC2, EGFR
8irinotecan44 50 1212.3TNFRSF10B, ERCC2, EGFR
9naltrexone44 29 50 1213.3OGFR, PENK
10imatinib44 50 1212.3PTEN, CCR7, EGFR
11gemcitabine44 50 1212.2TNFRSF10B, PTEN, ERCC2, EGFR
12bcnu4410.2EGFR, ERCC2
13bicalutamide44 60 1212.2EGFR, PTEN
145fluorouracil4410.2EGFR, ERCC2, PTEN, TNFRSF10B
15cisplatin44 50 60 1213.1ING1, TNFRSF10B, PTEN, ERCC2, EGFR
16paclitaxel44 50 1212.0EGFR, ERCC2, PTEN, TNFRSF10B, ING1, PENK
17cycloheximide449.9PENK, TNFRSF10B, PTEN, EGFR
18cetuximab44 50 1211.9EGFR, PTEN
19progesterone44 29 60 25 1213.7DEFB103B, PENK, PTEN, EGFR

GO Terms for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Biological processes related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:00761110.2EGFR, PTEN
2apoptotic processGO:0069159.6ERCC2, PTEN, TNFRSF10B, PMAIP1

Products for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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  • Antibodies
  • Proteins
  • Lysates
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  • Proteins
  • Kits and Assays

Sources for Squamous Cell Carcinoma of the Head and Neck

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet