HNSCC
MCID: SQM007
MIFTS: 50

Squamous Cell Carcinoma of the Head and Neck (HNSCC) malady

Cancer diseases category

Summaries for Squamous Cell Carcinoma of the Head and Neck

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Head and neck cancer refers to a group of biologically similar cancers that start in the lip, oral... more...

MalaCards: Squamous Cell Carcinoma of the Head and Neck, also known as head and neck squamous cell carcinoma, is related to squamous cell carcinoma and breast cancer. An important gene associated with Squamous Cell Carcinoma of the Head and Neck is TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b), and among its related pathways are Rho Family GTPases and PAK Pathway. The compounds 5fluorouracil and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related mouse phenotypes are cellular and tumorigenesis.

Description from OMIM:46 275355

Aliases & Classifications for Squamous Cell Carcinoma of the Head and Neck

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42NIH Rare Diseases, 60UMLS, 22GTR, 48Orphanet, 44Novoseek, 46OMIM, 35MESH via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
head and neck squamous cell carcinoma:
Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

squamous cell carcinoma of the head and neck 42
head and neck squamous cell carcinoma 42 22 48
hnscc 42 44 48
carcinoma, squamous cell of head and neck 42 60
squamous cell carcinoma of head and neck 48
squamous cell carcinoma, head and neck 46


External Ids:

OMIM46 275355
MESH via Orphanet35 C535575
UMLS via Orphanet61 C1168401

Related Diseases for Squamous Cell Carcinoma of the Head and Neck

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17GeneCards, 18GeneDecks
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Diseases related to Squamous Cell Carcinoma of the Head and Neck via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.7IVL, ING1, PTEN, CCR7, ERCC2, PENK
2breast cancer30.9ERCC2, CSTA, CTTN, IVL, PTEN, ERCC1
3colorectal cancer30.8ERCC2, TNFRSF10B, ERCC1, ING1, PTEN, XRCC1
4lung cancer30.8ING1, CSTA, XRCC1, TNFRSF10B, ERCC1, ERCC2
5prostate cancer30.8CTTN, ERCC1, PTEN, XRCC1
6leukemia30.7XRCC1, CCR7, IVL, ERCC2, TNFRSF10B
7basal cell carcinoma30.7ERCC2, IVL, XRCC1, ERCC1
8adenocarcinoma30.6ERCC1, XRCC1, CSTA, TNFRSF10B, OGFR, IVL
9non-small cell lung carcinoma30.6CCR7, ERCC2, PTEN, TNFRSF10B, CSTA, XRCC1
10melanoma30.5ERCC2, ERCC1, PTEN, ING1, TNFRSF10B, XRCC1
11bladder carcinoma30.5XRCC1, CTTN, ERCC1, ERCC2, TNFRSF10B
12basaloid squamous cell carcinoma11.0
13cervical squamous cell carcinoma10.8
14cervicitis10.8
15squamous cell papilloma10.7
16papilloma10.7
17dermatitis10.7
18skin squamous cell carcinoma10.7
19papillary carcinoma10.6
20papillary squamous carcinoma10.6
21small cell carcinoma10.6
22breast squamous cell carcinoma10.6
23lung squamous cell carcinoma10.6
24transitional cell carcinoma10.6
25ataxia telangiectasia10.6
26bone carcinoma10.5
27adenoid squamous cell carcinoma10.5
28prostate squamous cell carcinoma10.5
29adenoiditis10.5
30esophagitis10.5
31prostatitis10.5
32periodontitis10.5
33retinoblastoma10.5
34squamous cell carcinoma, head and neck, somatic10.5
35parathyroid carcinoma10.4
36myelitis10.4
37hepatitis c10.4
38prostate small cell carcinoma10.4
39keratinizing squamous cell carcinoma10.4
40spindle cell carcinoma10.4
41nasopharyngitis10.4
42hypercalcemia10.4
43adenoid cystic carcinoma10.4
44acne10.4
45anal squamous cell carcinoma10.4
46esophageal cancer10.4
47esophagus squamous cell carcinoma10.4
48hepatitis10.4
49herpes simplex10.4
50leiomyosarcoma10.4

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma of the Head and Neck:



Diseases related to squamous cell carcinoma of the head and neck

Clinical Features for Squamous Cell Carcinoma of the Head and Neck

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46OMIM
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Clinical features from OMIM:

275355

Clinical synopsis from OMIM:

275355

Drugs & Therapeutics for Squamous Cell Carcinoma of the Head and Neck

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Squamous Cell Carcinoma of the Head and Neck

Drug clinical trials:

Search ClinicalTrials for Squamous Cell Carcinoma of the Head and Neck

Search NIH Clinical Center for Squamous Cell Carcinoma of the Head and Neck

Search CenterWatch for Squamous Cell Carcinoma of the Head and Neck

Genetic Tests for Squamous Cell Carcinoma of the Head and Neck

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22GTR
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Genetic tests related to Squamous Cell Carcinoma of the Head and Neck:

id Genetic test Affiliating Genes
1 Squamous Cell Carcinoma of the Head and Neck22

Anatomical Context for Squamous Cell Carcinoma of the Head and Neck

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32MalaCards
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MalaCards organs/tissues related to Squamous Cell Carcinoma of the Head and Neck:

32
Lymph node

Animal Models for Squamous Cell Carcinoma of the Head and Neck or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Squamous Cell Carcinoma of the Head and Neck:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.2PMAIP1, CCR7, XRCC1, TNFRSF10B, CTTN, ING1
2MP:000200610.7PMAIP1, XRCC1, TNFRSF10B, ING1, PTEN, ERCC1

Publications for Squamous Cell Carcinoma of the Head and Neck

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Genetic Variations for Squamous Cell Carcinoma of the Head and Neck

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Squamous Cell Carcinoma of the Head and Neck:

62
id Symbol AA change Variation ID SNP ID
1ING1p.Ala335AspVAR_017420
2ING1p.Cys358SerVAR_017421
3ING1p.Asn359SerVAR_017422
4ING3p.Asp20GlyVAR_021263
5PTENp.Ala121GlyVAR_018103

Expression for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

Search GEO for disease gene expression data for Squamous Cell Carcinoma of the Head and Neck.

Pathways for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR
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Compounds related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
15fluorouracil4411.2ERCC2, ERCC1, PTEN, IVL, TNFRSF10B, XRCC1
2tyrosine4411.2CCR7, XRCC1, CSTA, CTTN, IVL, PTEN
3cisplatin44 49 59 1114.2XRCC1, TNFRSF10B, ING1, PTEN, ERCC1, ERCC2
4etoposide44 49 59 1114.1XRCC1, TNFRSF10B, ING1, PTEN, ERCC1
5paclitaxel44 49 1113.1TNFRSF10B, PTEN, ERCC1, ERCC2
6oxaliplatin44 49 1113.1XRCC1, TNFRSF10B, ERCC1, ERCC2
7irinotecan44 49 1113.1XRCC1, TNFRSF10B, ERCC1, ERCC2
8pd 98,0594411.0PENK, ERCC1, PTEN, IVL, CTTN
9gemcitabine44 49 1113.0ERCC2, ERCC1, PTEN, TNFRSF10B
10platinum compounds4911.0ERCC2, ERCC1, XRCC1
11cyclophosphamide44 49 1112.9XRCC1, PTEN, ERCC1, ERCC2
12platinum44 4911.9XRCC1, ERCC1, ERCC2
13vegf4410.9ERCC2, ERCC1, PTEN, IVL, TNFRSF10B
14vincristine44 49 1112.8PTEN, ERCC1, ERCC2
15oligonucleotide4410.8XRCC1, IVL, PTEN, ERCC1, PENK
16thymidylate4410.7ERCC2, ERCC1, XRCC1
17gw966244 2811.3PTEN, TNFRSF10B

GO Terms for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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16Gene Ontology
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Cellular components related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:00153310.6IVL, CSTA

Biological processes related to Squamous Cell Carcinoma of the Head and Neck according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1UV protectionGO:00965010.6ERCC2, ERCC1
2peptide cross-linkingGO:01814910.6IVL, CSTA
3response to X-rayGO:01016510.5ERCC1, PMAIP1
4nucleotide-excision repair, DNA damage removalGO:00071810.3ERCC2, ERCC1

Products for genes affiliated with Squamous Cell Carcinoma of the Head and Neck

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Sources for Squamous Cell Carcinoma of the Head and Neck

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet