MCID: SQM002
MIFTS: 39

Squamous Cell Papilloma

Categories: Skin diseases, Cancer diseases

Aliases & Classifications for Squamous Cell Papilloma

MalaCards integrated aliases for Squamous Cell Papilloma:

Name: Squamous Cell Papilloma 12 14
Papilloma 41 69
Papilloma, Squamous Cell 69
Epidermoid Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:139
MeSH 41 D010212
NCIt 46 C3712
SNOMED-CT 64 63451008
UMLS 69 C0205874

Summaries for Squamous Cell Papilloma

MalaCards based summary : Squamous Cell Papilloma, also known as papilloma, is related to papilloma of choroid plexus and squamous cell papilloma of skin. An important gene associated with Squamous Cell Papilloma is CNTROB (Centrobin, Centriole Duplication And Spindle Assembly Protein), and among its related pathways/superpathways are TP53 Regulates Transcription of Cell Cycle Genes and Cardiomyocyte Differentiation through BMP Receptors. The drugs Cervarix and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include cervix, tongue and skin, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 72 A squamous cell papilloma is a generally benign papilloma that arises from the stratified squamous... more...

Related Diseases for Squamous Cell Papilloma

Diseases related to Squamous Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 papilloma of choroid plexus 12.5
2 squamous cell papilloma of skin 12.1
3 esophagus squamous cell papilloma 12.1
4 inverted papilloma 11.2
5 papilloma 10.6
6 abdominal tuberculosis 10.3 F2 TBP
7 cerebral falx meningioma 10.3 F2 F3
8 mucoepidermoid esophageal carcinoma 10.3 TP53 WWOX
9 intestinal impaction 10.3 F2 F3
10 fournier gangrene 10.3 F2 F3
11 cerebral sinovenous thrombosis 10.3 F2 F3
12 leech infestation 10.3 F2 F3
13 von willebrand disease, type 1 10.3 F2 F3
14 qualitative platelet defect 10.3 F2 F3
15 giant hemangioma 10.2 F2 F3
16 sagittal sinus thrombosis 10.2 F2 F3
17 lymph node cancer 10.2 TP53 WWOX
18 blue toe syndrome 10.2 F2 F3
19 papilledema 10.2 F2 TP53
20 intracranial embolism 10.2 F2 F3
21 esophagitis 10.2
22 femoral neuropathy 10.2 F2 F3
23 esophageal basaloid squamous cell carcinoma 10.1 SFRP4 TP53 WWOX
24 alcohol-related birth defect 10.1 F2 F3
25 anterior cranial fossa meningioma 10.1 F2 F3 TP53
26 hantavirus pulmonary syndrome 10.1 F2 F3
27 endocardium disease 10.1 F2 F3 HSPD1
28 laryngitis 10.0
29 gastrointestinal system cancer 10.0 F2 TP53 WWOX
30 marantic endocarditis 10.0 F2 F3
31 squamous cell carcinoma 9.9
32 dysphagia 9.9
33 essential thrombocythemia 9.8 F2 F3 TP53
34 splenic disease 9.8 F2 F3
35 mucositis 9.8
36 urethritis 9.8
37 peptic esophagitis 9.8
38 pharyngitis 9.8
39 adenoma 9.8
40 lichen planus 9.8
41 laryngeal papillomatosis 9.8

Graphical network of the top 20 diseases related to Squamous Cell Papilloma:



Diseases related to Squamous Cell Papilloma

Symptoms & Phenotypes for Squamous Cell Papilloma

MGI Mouse Phenotypes related to Squamous Cell Papilloma:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 HPGDS HSPD1 NMU TBP TP53 BMP5
2 growth/size/body region MP:0005378 10.21 AURKA BMP2 BMP5 ELP1 F2 F3
3 homeostasis/metabolism MP:0005376 10.14 TP53 WWOX BMP2 CYP2E1 ELP1 F2
4 cardiovascular system MP:0005385 10.13 BMP2 BMP5 CYP2E1 ELP1 F2 F3
5 mortality/aging MP:0010768 10.13 WWOX AURKA BMP2 BMP5 CYP2E1 ELP1
6 embryo MP:0005380 10.11 AURKA BMP2 BMP5 ELP1 F2 F3
7 immune system MP:0005387 10.07 BMP2 BMP5 ELP1 F2 F3 HPGDS
8 nervous system MP:0003631 9.85 F3 HPGDS HSPD1 TBP TP53 WWOX
9 neoplasm MP:0002006 9.73 AURKA CYP2E1 F3 HPGDS TP53 WWOX
10 reproductive system MP:0005389 9.56 BMP2 BMP5 CLDN11 F2 HSPD1 SFRP4
11 skeleton MP:0005390 9.23 BMP2 BMP5 ELP1 F2 SFRP4 TBP

Drugs & Therapeutics for Squamous Cell Papilloma

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cervarix 17 45 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009

Drugs for Squamous Cell Papilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 3
2 Antiviral Agents Phase 3
3 Immunoglobulins Phase 3
4 Vaccines Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Active, not recruiting NCT01375868 Phase 3

Search NIH Clinical Center for Squamous Cell Papilloma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: papilloma

Genetic Tests for Squamous Cell Papilloma

Anatomical Context for Squamous Cell Papilloma

MalaCards organs/tissues related to Squamous Cell Papilloma:

38
Cervix, Tongue, Skin, Trachea, Lung

Publications for Squamous Cell Papilloma

Articles related to Squamous Cell Papilloma:

(show all 48)
# Title Authors Year
1
Laryngeal squamous cell papilloma is highly associated with human papillomavirus. ( 29447361 )
2018
2
Endoscopic mucosal resection of rectal squamous cell papilloma. ( 29351698 )
2018
3
Giant Ocular Surface Squamous Cell Papilloma Treated With Topical Mitomycin C. ( 28715561 )
2017
4
Esophageal Squamous Cell Papilloma. ( 27751518 )
2017
5
Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma. ( 27696538 )
2016
6
Partial glossectomy for treating extensive oral squamous cell papilloma. ( 27544018 )
2016
7
Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus. ( 27001250 )
2016
8
Verrucous carcinoma and squamous cell papilloma of the oral cavity: Report of two cases and review of literature. ( 26430380 )
2015
9
Recalcitrant oral squamous cell papilloma lesions in two HIV-infected patients successfully treated with topical imiquimod. ( 25932059 )
2015
10
Esophageal Squamous Cell Papilloma: A Not-So-Rare Cause of Dysphagia. ( 27134598 )
2015
11
Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report. ( 26137004 )
2015
12
Oral pathology quiz #85. Case number 2. Squamous cell papilloma. ( 25739139 )
2014
13
Oral focal fibrous hyperplasia and squamous cell papilloma treated with an erbium laser. Case presentation. ( 24654496 )
2014
14
Urethral squamous cell papilloma: Case report and literature review. ( 24940467 )
2014
15
Solitary bronchial squamous cell papilloma - another human papillomavirus (HPV)-associated benign tumor: systematic review and meta-analysis. ( 24596531 )
2013
16
Squamous cell papilloma of the urinary bladder endoscopically mimicking cancer. ( 24159399 )
2013
17
Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection. ( 22215212 )
2012
18
Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature. ( 23055678 )
2012
19
Oral pathology quiz # 42. Case 2. Squamous cell papilloma. ( 15160431 )
2004
20
Oral pathology quiz #43. Case number 4. Squamous cell papilloma. ( 16795958 )
2004
21
Alcohol, smoking and papillomavirus infection as risk factors for esophageal squamous-cell papilloma and esophageal squamous-cell carcinoma in Italy. ( 10842204 )
2000
22
Solitary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis. ( 10849335 )
2000
23
Squamous cell papilloma of the esophagus. ( 8855780 )
1996
24
Squamous cell papilloma of the esophagus: a clinicopathologic and follow-up study of 25 cases. ( 8304311 )
1994
25
Detection of human papilloma virus type 6 DNA in an esophageal squamous cell papilloma. ( 8013499 )
1994
26
Prognostic importance of human papilloma virus typing in squamous cell papilloma of the bronchus: comparison of in situ hybridization and the polymerase chain reaction. ( 7959664 )
1994
27
Esophageal squamous cell papilloma, suspected of squamous cell carcinoma. ( 8012070 )
1993
28
Solitary squamous cell papilloma of the trachea. ( 8417677 )
1993
29
Cytological appearances of a solitary squamous cell papilloma with associated mucous gland adenoma in the lung. ( 1421008 )
1992
30
A squamous cell papilloma as a cause of dysphagia and vomiting. ( 2369543 )
1990
31
Detection of human papillomavirus type 11 DNA in a conjunctival squamous cell papilloma by in situ hybridization with biotinylated probes. ( 2801046 )
1989
32
Squamous cell papilloma at the tracheoesophageal puncture stoma. ( 3355697 )
1988
33
Squamous cell papilloma of the esophagus. Report on 35 endoscopic cases. ( 3342776 )
1988
34
Pigmented squamous cell papilloma--a case report. ( 3507413 )
1987
35
Squamous cell papilloma of the esophagus: report of four cases. ( 3996864 )
1985
36
Squamous cell papilloma of the esophagus in a child. ( 4055285 )
1985
37
Endoscopic removal of squamous cell papilloma of esophagus: a case report and review of literature. ( 6400387 )
1984
38
Evidence suggesting human papillomavirus (HPV) etiology for the squamous cell papilloma of the paranasal sinus. ( 6305303 )
1983
39
Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV). ( 6188592 )
1982
40
Squamous cell papilloma of the esophagus: a case report and review of the literature. ( 7451069 )
1980
41
Squamous cell papilloma of the esophagus. Report of a case after peptic esophagitis and repeated bougienage with review of the literature. ( 640347 )
1978
42
Squamous cell papilloma of esophagus. ( 737594 )
1978
43
Oral epithelial atypia in denture induced hyperplasia, lichen planus and squamous cell papilloma. ( 804458 )
1975
44
Solitary squamous cell papilloma of bronchial origin. ( 4899741 )
1969
45
The vascular bed in squamous-cell papilloma of the cervix and its significance for the colposcopical diagnosis of these lesions. ( 5707024 )
1968
46
Squamous cell papilloma of the external auditory canal and middle ear treated with radiation therapy. ( 5701321 )
1968
47
Squamous-cell papilloma of the uterine cervix; report of a case. ( 13502811 )
1957
48
Squamous cell papilloma of the cervix uteri. ( 13005077 )
1952

Variations for Squamous Cell Papilloma

Expression for Squamous Cell Papilloma

Search GEO for disease gene expression data for Squamous Cell Papilloma.

Pathways for Squamous Cell Papilloma

GO Terms for Squamous Cell Papilloma

Cellular components related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pronucleus GO:0045120 8.62 AURKA TBP

Biological processes related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.85 BMP2 BMP5 CNOT2 F2 SFRP4 TP53
2 positive regulation of apoptotic process GO:0043065 9.71 BMP2 HSPD1 SFRP4 TP53
3 regulation of signal transduction by p53 class mediator GO:1901796 9.61 AURKA TBP TP53
4 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.46 BMP2 TP53
5 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 AURKA CNOT2 TP53
6 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.32 BMP2 BMP5
7 negative regulation of steroid biosynthetic process GO:0010894 9.16 BMP2 BMP5
8 negative regulation of aldosterone biosynthetic process GO:0032348 8.96 BMP2 BMP5
9 negative regulation of cortisol biosynthetic process GO:2000065 8.62 BMP2 BMP5

Molecular functions related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.02 CYP2E1 HSPD1 TBP TP53 WWOX
2 BMP receptor binding GO:0070700 8.96 BMP2 BMP5
3 protein binding GO:0005515 10.03 AURKA BMP2 CLDN11 CNOT2 CNTROB ELP1

Sources for Squamous Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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