MCID: STL001
MIFTS: 46

St. Louis Encephalitis malady

Infectious diseases, Neuronal diseases categories

Summaries for St. Louis Encephalitis

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Sources:
8Disease Ontology, 3CDC, 32MalaCards
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CDC:3 Saint Louis encephalitis virus (SLEV) is transmitted to humans by the bite of an infected mosquito. Most cases of SLEV disease have occurred in eastern and central states (see map). Most persons infected with SLEV have no apparent illness. Initial symptoms of those who become ill include fever, headache, nausea, vomiting, and tiredness. Severe neuroinvasive disease (often involving encephalitis, an inflammation of the brain) occurs more commonly in older adults. In rare cases, long-term disability or death can result. There is no specific treatment for SLEV infection; care is based on symptoms. You can reduce your risk of being infected with SLEV by using insect repellent, wearing protective clothing, and staying indoors while mosquitoes are most active. If you think you or a family member may have SLEV neuroinvasive disease, it is important to consult your healthcare provider for proper diagnosis.

MalaCards: St. Louis Encephalitis, also known as neuroinvasive st. louis encephalitis virus infection, is related to encephalitis and western equine encephalitis, and has symptoms including spastic paralysis, disorientation and stupor. An important gene associated with St. Louis Encephalitis is CD40LG (CD40 ligand), and among its related pathways are Cell adhesion molecules (CAMs) and Allograft rejection. The compounds rottlerin and herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in st. louis encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions and has symptom spastic paralysis.

Aliases & Classifications for St. Louis Encephalitis

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
st. louis encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

st. louis encephalitis 8 10 48
neuroinvasive st. louis encephalitis virus infection 8
saint louis encephalitis 48
encephalitis, st. louis 60


External Ids:

Disease Ontology8 DOID:10845
MeSH34 D004674
ICD9CM27 062.3
MESH via Orphanet35 D004674
ICD10 via Orphanet26 A83.3
SNOMED-CT via Orphanet57 417192005, 417607009
UMLS via Orphanet61 C0014060
ICD1025 A83.3

Related Diseases for St. Louis Encephalitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to St. Louis Encephalitis:



Diseases related to st. louis encephalitis

Clinical Features for St. Louis Encephalitis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • spastic paralysis
  • disorientation
  • stupor
  • high fever
  • neck stiffness
  • tremors
  • coma
  • convulsions
  • headache

Drugs & Therapeutics for St. Louis Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for St. Louis Encephalitis

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Anatomical Context for St. Louis Encephalitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to St. Louis Encephalitis:

32
Brain, Testes, Kidney, Salivary gland, Pituitary, Thyroid

FMA organs/tissues related to St. Louis Encephalitis:

14
Brain

Animal Models for St. Louis Encephalitis or affiliated genes

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Publications for St. Louis Encephalitis

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Sources:
50PubMed
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Articles related to St. Louis Encephalitis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Silent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005). (22303490)
2012
2
Evaluation of widely used diagnostic tests to detect West Nile virus infections in horses previously infected with St. Louis encephalitis virus or dengue virus type 2. (21346058)
2011
3
Immunoglobulin G subclasses in antibody responses to St. Louis encephalitis virus infections. (21688106)
2011
4
High throughput quantitative colorimetric microneutralization assay for the confirmation and differentiation of West Nile Virus and St. Louis encephalitis virus. (20207881)
2010
5
Mosquito fauna inhabiting water bodies in the urban environment of CA^rdoba city, Argentina, following a St. Louis encephalitis outbreak. (21175948)
2010
6
Comparative thermostability of West Nile, St. Louis encephalitis, and western equine encephalomyelitis viruses during heat inactivation for serologic diagnostics. (19407138)
2009
7
Serologic diagnosis of West Nile and St. Louis encephalitis virus infections in domestic chickens. (18337340)
2008
8
Phylogenetic and evolutionary analyses of St. Louis encephalitis virus genomes. (18374605)
2008
9
Avian host and mosquito (Diptera: Culicidae) vector competence determine the efficiency of West Nile and St. Louis encephalitis virus transmission. (15962789)
2005
10
Effect of dose on house finch infection with western equine encephalomyelitis and St. Louis encephalitis viruses. (15535631)
2004
11
The spatial-temporal distribution of drought, wetting, and human cases of St. Louis encephalitis in southcentral Florida. (15381802)
2004
12
Persistence and amplification of St. Louis encephalitis virus in the Coachella Valley of California, 2000-2001. (12349864)
2002
13
St. Louis encephalitis outbreak in Louisiana in 2001. (12517026)
2002
14
Phylogenetic analysis of the envelope gene of St. Louis encephalitis virus. (11811684)
2001
15
St. Louis Encephalitis and West Nile Virus Encephalitis. (11487457)
2001
16
Use of base excision sequence scanning for detection of genetic variations in St. Louis encephalitis virus isolates. (10325350)
1999
17
Epidemiologic aspects of a St. Louis encephalitis outbreak in Fort Walton Beach, Florida in 1980. (8147497)
1994
18
Use of the polymerase chain reaction for the sensitive detection of St. Louis encephalitis viral RNA. (1348060)
1992
19
Preliminary studies of Aedes bahamensis as a host and potential vector of St. Louis encephalitis virus. (2045810)
1991
20
Vertical transmission of St. Louis encephalitis virus to autogenously developed eggs of Aedes atropalpus mosquitoes. (2098473)
1990
21
Update: St. Louis encephalitis--Florida and Texas, 1990. (2120573)
1990
22
Entomologic studies after a St. Louis encephalitis epidemic in Grand Junction, Colorado. (2899394)
1988
23
Epidemiological aspects of a St. Louis encephalitis outbreak in Harris County, Texas, 1986. (2891777)
1988
24
Evaluation of the CDC gravid trap for the surveillance of St. Louis encephalitis vectors in Memphis, Tennessee. (3507491)
1986
25
Experimental transovarial transmission of St. Louis encephalitis virus by Culex and Aedes mosquitoes. (6696174)
1984
26
Leads from the MMWR. St Louis encephalitis--California. (6512923)
1984
27
St. Louis encephalitis--Florida 1977. Patterns of a widespread outbreak. (6132561)
1983
28
Brainstem encephalitis with serological evidence of St Louis encephalitis. (7241168)
1981
29
Transmission of St. Louis encephalitis virus from Argentina by mosquitoes of the Culex pipiens (Diptera: Culicidae) complex. (7401124)
1980
30
Variation among strains of St. Louis encephalitis virus: basis for a genetic, pathogenetic, and epidemiologic classification. (6261645)
1980
31
Epidemiology and control of St. Louis encephalitis in Birmingham, Alabama, 1975. (655320)
1978
32
Intrauterine infection of mice with St. Louis encephalitis virus: immunological, physiological, neurological, and behavioral effects on progeny. (1193727)
1975
33
Cross-protection between group B arboviruses: resistance in mice to Japanese B encephalitis and St. Louis encephalitis viruses induced by Dengue virus immunization. (4363234)
1974
34
The effect of environmental temperature upon the transmission of St. Louis encephalitis virus by Culex pipiens quinquefasciatus. (4697417)
1973
35
Experimental cyclic transmission of St. Louis encephalitis virus in chickens and Culex mosquitoes through a year. (5652338)
1968
36
The epidemiology of St. Louis encephalitis in Houston, Texas, 1964. (6081383)
1967
37
Isolation of St. Louis encephalitis virus from bats (Tadarida b. mexicana) in Texas. (12325353)
1966
38
Studies of arthropod-borne virus infections in Chiroptera. 3. Influence of environmental temperature on experimental infection with Japanese B and St. Louis encephalitis viruses. (4287167)
1966
39
St. Louis encephalitis in Panama. III. Investigation of local mammals and birds as possible reservoir hosts. (13742498)
1961
40
St. Louis encephalitis in Calvert City, Kentucky, 1955; an epidemiologic study. (13410906)
1957
41
Western equine and St. Louis encephalitis; preliminary report of a clinical follow-up study in California. (14370373)
1955
42
Studies on mites as vectors of western equine and St. Louis encephalitis viruses in California. (13228852)
1955
43
Effect of pregnancy upon the immunity of mice vaccinated against St. Louis encephalitis virus. (13011696)
1952
44
The effect of chemical substances in mice infected with St. Louis encephalitis, PR8 strain of influenza, or the lansing strain of poliomyelitis virus. (14938551)
1952
45
MULTIPLICATION AND SPREAD OF THE VIRUS OF ST. LOUIS ENCEPHALITIS IN MICE WITH SPECIAL EMPHASIS ON ITS FATE IN THE ALIMENTARY TRACT. (19871641)
1947
46
Isolation of St. Louis encephalitis virus from the peripheral blood of a human subject. (21023178)
1946
47
BLOOD-SUCKING VECTORS OF ENCEPHALITIS: EXPERIMENTAL TRANSMISSION OF ST. LOUIS ENCEPHALITIS (HUBBARD STRAIN) TO WHITE SWISS MICE BY THE AMERICAN DOG TICK, DERMACENTOR VARIABILIS SAY. (19871380)
1944
48
Human Equine Encephalomyelitis and St. Louis Encephalitis in California, 1939-1941. (18015614)
1942
49
WESTERN EQUINE AND ST. LOUIS ENCEPHALITIS ANTIBODIES IN THE SERA OF MAMMALS AND BIRDS FROM AN ENDEMIC AREA. (17809735)
1941
50
Cultivation of the Virus of St. Louis Encephalitis. (19970332)
1937

Genetic Variations for St. Louis Encephalitis

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Expression for genes affiliated with St. Louis Encephalitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with St. Louis Encephalitis

Search GEO for disease gene expression data for St. Louis Encephalitis.

Pathways for genes affiliated with St. Louis Encephalitis

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Sources:
29KEGG, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with St. Louis Encephalitis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rottlerin449.5RAF1, CD40LG
2herbimycin a44 5910.5RAF1, CD40LG
3rituximab44 49 1111.4RAF1, CD40LG
4theophylline44 28 11 2412.2RAF1, CD40LG

GO Terms for genes affiliated with St. Louis Encephalitis

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16Gene Ontology
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Molecular functions related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2CD40LG, IFNA8

Products for genes affiliated with St. Louis Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for St. Louis Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet