MCID: STL001
MIFTS: 51

St. Louis Encephalitis malady

Infectious diseases, Neuronal diseases, Rare diseases categories
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Summaries for St. Louis Encephalitis

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Sources:
8Disease Ontology, 4CDC, 33MalaCards
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Fully expand this MalaCard
CDC:4 Saint Louis encephalitis virus (SLEV) is transmitted to humans by the bite of an infected mosquito. Most cases of SLEV disease have occurred in eastern and central states (see map). Most persons infected with SLEV have no apparent illness. Initial symptoms of those who become ill include fever, headache, nausea, vomiting, and tiredness. Severe neuroinvasive disease (often involving encephalitis, an inflammation of the brain) occurs more commonly in older adults. In rare cases, long-term disability or death can result. There is no specific treatment for SLEV infection; care is based on symptoms. You can reduce your risk of being infected with SLEV by using insect repellent, wearing protective clothing, and staying indoors while mosquitoes are most active. If you think you or a family member may have SLEV neuroinvasive disease, it is important to consult your healthcare provider for proper diagnosis.

MalaCards: St. Louis Encephalitis, also known as neuroinvasive st. louis encephalitis virus infection, is related to encephalitis and encephalomyelitis, and has symptoms including spastic paralysis, tremors and stupor. An important gene associated with St. Louis Encephalitis is CD40LG (CD40 ligand), and among its related pathways are Allograft rejection and Influenza A. The compounds rottlerin and rituximab have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in st. louis encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions and has symptom spastic paralysis.

Aliases & Classifications for St. Louis Encephalitis

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Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
st. louis encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

st. louis encephalitis 8 10 49
neuroinvasive st. louis encephalitis virus infection 8
saint louis encephalitis 49
encephalitis, st. louis 62


External Ids:

Disease Ontology8 DOID:10845
MeSH35 D004674
ICD9CM27 062.3
MESH via Orphanet36 D004674
ICD10 via Orphanet26 A83.3
SNOMED-CT via Orphanet59 417192005, 417607009
UMLS via Orphanet63 C0014060
ICD1025 A83.3

Related Diseases for St. Louis Encephalitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to St. Louis Encephalitis:



Diseases related to st. louis encephalitis

Symptoms for St. Louis Encephalitis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • spastic paralysis
  • tremors
  • stupor
  • neck stiffness
  • coma
  • disorientation
  • high fever
  • convulsions
  • headache

Drugs & Therapeutics for St. Louis Encephalitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for St. Louis Encephalitis

Search NIH Clinical Center for St. Louis Encephalitis

Genetic Tests for St. Louis Encephalitis

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Anatomical Context for St. Louis Encephalitis

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to St. Louis Encephalitis:

33
Brain, Testes, Kidney, Pituitary, Salivary gland, Thyroid

FMA organs/tissues related to St. Louis Encephalitis:

14
Brain

Animal Models for St. Louis Encephalitis or affiliated genes

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Publications for St. Louis Encephalitis

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Sources:
52PubMed
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Articles related to St. Louis Encephalitis:

(show top 50)    (show all 389)
idTitleAuthorsYear
1
Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes. (21940408)
2012
2
Silent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005). (22303490)
2012
3
Temporal and spatial alterations in mutant swarm size of St. Louis encephalitis virus in mosquito hosts. (21215334)
2011
4
Evolution and dispersal of St. Louis encephalitis virus in the Americas. (18708161)
2009
5
Persistent West Nile virus transmission and the apparent displacement St. Louis encephalitis virus in southeastern California, 2003-2006. (18533445)
2008
6
A duplex real-time reverse transcriptase polymerase chain reaction assay for the detection of St. Louis encephalitis and eastern equine encephalitis viruses. (18715737)
2008
7
Construction of yellow fever/St. Louis encephalitis chimeric virus and the use of chimeras as a diagnostic tool. (15569798)
2004
8
Serologic evidence of West Nile virus and St. Louis encephalitis virus infections in white-tailed deer (Odocoileus virginianus) from New Jersey, 2001. (15671740)
2004
9
Wild terrestrial rainforest mammals as potential reservoirs for flaviviruses (yellow fever, dengue 2 and St Louis encephalitis viruses) in French Guiana. (15138077)
2004
10
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. (12958248)
2003
11
The neurobehavioural consequences of St. Louis encephalitis infection. (12419004)
2002
12
Viremia and serological responses in adult chickens infected with western equine encephalomyelitis and St. Louis encephalitis viruses. (7707063)
1994
13
Comparison of chickens and pheasants as sentinels for eastern equine encephalitis and St. Louis encephalitis viruses in Florida. (7707062)
1994
14
Preliminary studies of Aedes bahamensis as a host and potential vector of St. Louis encephalitis virus. (2045810)
1991
15
Distribution of St. Louis encephalitis viral antibody in sentinel chickens maintained in Sarasota County, Florida: 1978-1988. (2033613)
1991
16
Vertical transmission of St. Louis encephalitis virus to autogenously developed eggs of Aedes atropalpus mosquitoes. (2098473)
1990
17
Surveillance of St. Louis encephalitis virus vectors in Grand Junction, Colorado, in 1987. (2746202)
1989
18
Antibody prevalence of St. Louis encephalitis virus in avian hosts in Los Angeles, California, 1986. (2852209)
1988
19
Entomologic studies after a St. Louis encephalitis epidemic in Grand Junction, Colorado. (2899394)
1988
20
Epidemiological aspects of a St. Louis encephalitis outbreak in Harris County, Texas, 1986. (2891777)
1988
21
Establishment and characterization of St Louis encephalitis virus persistent infections in Aedes and Culex mosquito cell lines. (2842432)
1988
22
Epidemiologic aspects of a St. Louis encephalitis outbreak in Mesa County, Colorado. (2887107)
1987
23
Serologic evidence for widespread infection with La Crosse and St. Louis encephalitis viruses in the Indiana human population. (6328975)
1984
24
Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)
1981
25
Transovarial transmission of St. Louis encephalitis virus by Culex pipiens complex mosquitoes. (6266266)
1981
26
Transmission of St. Louis encephalitis virus from Argentina by mosquitoes of the Culex pipiens (Diptera: Culicidae) complex. (7401124)
1980
27
Geographic variation among St. Louis encephalitis virus strains in the viremic responses of avian hosts. (7446828)
1980
28
Epidemiology of St. Louis encephalitis and other acute encephalitides. (570348)
1978
29
The epidemiology of St. Louis encephalitis in Dallas, Texas, 1966. (1155433)
1975
30
Isolation of St. Louis encephalitis and Cache Valley viruses from Saskatchewan mosquitoes. (4147200)
1973
31
Recurrent St. Louis encephalitis infection in residents of a flood plain of the Trinity River, Roosevelt Heights (Dallas, Texas). (5048980)
1972
32
Economic cost of St. Louis encephalitis epidemic in Dallas, Texas, 1966. (4971084)
1968
33
Preparation of inactivated St. Louis encephalitis virus vaccine from hamster kidney cell culture. (5924439)
1966
34
St. Louis encephalitis: age aspects of 1962 epidemic in Pinellas County, Florida. (5931332)
1966
35
Follow-up studies of St. Louis encephalitis in Florida: serologic findings eighteen months to five years after epidemics. (4379099)
1966
36
ST. LOUIS ENCEPHALITIS IN CHILDREN DURING THE 1964 EPIDEMIC. (14313895)
1965
37
ISOLATIONS OF ST. LOUIS ENCEPHALITIS VIRUS FROM DOMESTIC PIGEONS, COLUMBA LIVIA. (14159988)
1964
38
ST. LOUIS ENCEPHALITIS IN PANAMA: A REVIEW AND A PROGRESS REPORT. (14162903)
1964
39
THE FIRST ISOLATION OF ST. LOUIS ENCEPHALITIS VIRUS FROM MOSQUITOES IN FLORIDA. (14232042)
1964
40
STUDIES OF ARTHROPOD-BORNE VIRUS INFECTIONS IN CHIROPTERA. I. SUSCEPTIBILITY OF INSECTIVOROUS SPECIES TO EXPERIMENTAL INFECTION WITH JAPANESE B AND ST. LOUIS ENCEPHALITIS VIRUSES. (14070775)
1963
41
Lower Rio Grande valley outbreak of St. Louis encephalitis. (13835654)
1959
42
St. Louis encephalitis in 1933; observations on epidemiological features. (13542726)
1958
43
The relationship of the epidemic keratoconjunctivitis virus of Sanders to the St. Louis encephalitis virus. (13411133)
1957
44
Polyradiculopathy in man produced by St. Louis encephalitis virus (SLE). (13076770)
1953
45
The hemagglutinin of St. Louis encephalitis virus. I. Recovery of stable hemagglutinin from the brains of infected mice. (13035118)
1953
46
A possible relationship between viruses of St. Louis encephalitis and epidemic keratoconjunctivitis. (14844416)
1951
47
Isolation of St. Louis encephalitis virus from a fatal human case in California. (21024144)
1946
48
pH stability of St. Louis encephalitis virus. (20277740)
1946
49
Persistence of the Virus of St. Louis Encephalitis in the Central Nervous System of Mice for Over Five Months. (16560683)
1943
50
Changes Produced in the Central Nervous System of the Mouse by the Virus of St. Louis Encephalitis. (19970185)
1934

Variations for St. Louis Encephalitis

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Expression for genes affiliated with St. Louis Encephalitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with St. Louis Encephalitis

Search GEO for disease gene expression data for St. Louis Encephalitis.

Pathways for genes affiliated with St. Louis Encephalitis

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 54R&D Systems, 60Thomson Reuters
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Pathways related to St. Louis Encephalitis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3IFNA8, CD40LG
2
Show member pathways
9.1RAF1, IFNA8
3
Show member pathways
9.1RAF1, IFNA8
49.1IFNA8, RAF1
5
Show member pathways
9.1RAF1, IFNA8
6
Show member pathways
9.1RAF1, IFNA8
79.1RAF1, IFNA8
8
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1RAF1, IFNA8
99.1RAF1, IFNA8
10
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1RAF1, IFNA8
11
Show member pathways
Immune response CD16 signaling in NK cells60
9.1RAF1, IFNA8
12
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0RAF1, CD40LG
13
Show member pathways
9.0CD40LG, RAF1
14
Show member pathways
8.5CD40LG, RAF1, IFNA8

Compounds for genes affiliated with St. Louis Encephalitis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to St. Louis Encephalitis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1rottlerin459.4CD40LG, RAF1
2rituximab45 51 1111.4CD40LG, RAF1
3theophylline45 29 24 1112.4RAF1, CD40LG
4herbimycin a45 6110.4CD40LG, RAF1
5phosphatidylserine45 29 1111.4CD40LG, RAF1
6vitamin a45 24 1111.4RAF1, CD40LG
7aspirin45 51 29 2412.3CD40LG, RAF1
8agar459.3CD40LG, RAF1
9n acetylcysteine459.3RAF1, CD40LG
10ascorbic acid45 2410.3CD40LG, RAF1
11indomethacin45 29 61 1112.3CD40LG, RAF1
12histamine45 29 2411.3RAF1, CD40LG
13acetylcholine45 51 29 24 1113.3CD40LG, RAF1
14rapamycin459.3CD40LG, RAF1
15doxorubicin45 51 1111.2RAF1, CD40LG
16genistein45 29 61 3 24 1114.2CD40LG, RAF1
17cyclosporin a45 29 6111.2CD40LG, RAF1
18pge2459.1RAF1, CD40LG
19dopamine45 29 24 1112.1CD40LG, RAF1
20cisplatin45 51 61 1112.0CD40LG, RAF1
21testosterone45 61 24 1112.0CD40LG, RAF1
22aspartate458.9RAF1, CD40LG
23heparin45 29 24 1111.7CD40LG, RAF1

GO Terms for genes affiliated with St. Louis Encephalitis

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Sources:
16Gene Ontology
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Biological processes related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:0421009.4CD40LG, IFNA8
2B cell differentiationGO:0301839.4CD40LG, IFNA8
3innate immune responseGO:0450879.1RAF1, IFNA8
4platelet activationGO:0301689.0CD40LG, RAF1
5negative regulation of apoptotic processGO:0430668.9RAF1, CD40LG
6blood coagulationGO:0075968.8IFNA8, RAF1

Molecular functions related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.3CD40LG, IFNA8

Products for genes affiliated with St. Louis Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for St. Louis Encephalitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet