MCID: STL001
MIFTS: 41

St. Louis Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for St. Louis Encephalitis

MalaCards integrated aliases for St. Louis Encephalitis:

Name: St. Louis Encephalitis 12 56 3 3 14
Encephalitis, St. Louis 42 69
Neuroinvasive St. Louis Encephalitis Virus Infection 12
Saint Louis Encephalitis 56

Characteristics:

Orphanet epidemiological data:

56
st. louis encephalitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:10845
ICD10 33 A83.3
ICD9CM 35 062.3
MeSH 42 D004674
Orphanet 56 ORPHA83484
MESH via Orphanet 43 D004674
UMLS via Orphanet 70 C0014060
ICD10 via Orphanet 34 A83.3
UMLS 69 C0014060

Summaries for St. Louis Encephalitis

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in brain, has material basis in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions and has symptom spastic paralysis.

MalaCards based summary : St. Louis Encephalitis, also known as encephalitis, st. louis, is related to japanese encephalitis and encephalitis. An important gene associated with St. Louis Encephalitis is C21orf2 (Chromosome 21 Open Reading Frame 2), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and PI3K-Akt signaling pathway. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and kidney.

Related Diseases for St. Louis Encephalitis

Diseases related to St. Louis Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
id Related Disease Score Top Affiliating Genes
1 japanese encephalitis 28.5 ERVW-1 KRAS RAF1 SNORA73B
2 encephalitis 11.2
3 west nile virus 10.5
4 yellow fever 10.3
5 bladder benign neoplasm 10.2 KRAS RAF1
6 keratoconjunctivitis 10.2
7 eastern equine encephalitis 10.2
8 diffuse pulmonary fibrosis 10.1 IFNA2 KRAS
9 dentin caries 10.1 IFNA2 RNASE3
10 poliomyelitis 10.1
11 radioulnar synostosis 10.0 KRAS RAF1
12 louping ill 10.0
13 venezuelan equine encephalitis 10.0
14 murray valley encephalitis 10.0
15 stomatitis 10.0
16 western equine encephalitis 10.0
17 rabies 10.0
18 cerebritis 10.0
19 functional diarrhea 10.0 ERVW-1 IFNA2
20 malaria 9.9
21 subacute thyroiditis 9.9
22 thyroiditis 9.9
23 cataract 9.9
24 neuronitis 9.9
25 chikungunya 9.9
26 influenza 9.9
27 tick-borne encephalitis 9.9
28 intrauterine infections 9.9
29 vascular disease 9.9
30 vaccinia 9.9
31 polyradiculopathy 9.9
32 olfactory neuroblastoma 9.8 KRAS RAF1
33 sexual masochism 6.3 C21orf2 ERVW-1 IFNA2 IFNA8 KRAS NXT1

Graphical network of the top 20 diseases related to St. Louis Encephalitis:



Diseases related to St. Louis Encephalitis

Symptoms & Phenotypes for St. Louis Encephalitis

Drugs & Therapeutics for St. Louis Encephalitis

Drugs for St. Louis Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acyclovir Phase 3
2 Anti-Infective Agents Phase 3,Phase 2,Phase 1
3 Antiviral Agents Phase 3
4 valacyclovir Phase 3
5
Atovaquone Approved Phase 2 95233-18-4 74989
6
Clarithromycin Approved Phase 2 81103-11-9 84029
7
Levoleucovorin Approved Phase 2 68538-85-2
8
Pyrimethamine Approved, Vet_approved Phase 2 58-14-0 4993
9
Sulfadiazine Approved, Vet_approved Phase 2 68-35-9 5215
10
Mefloquine Approved Phase 1, Phase 2 53230-10-7 4046
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
12
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
13
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
14 Anti-Bacterial Agents Phase 2
15 Antidotes Phase 2
16 Antimalarials Phase 2,Phase 1
17 Antiparasitic Agents Phase 2,Phase 1
18 Antiprotozoal Agents Phase 2,Phase 1
19 Calcium, Dietary Phase 2
20 Cytochrome P-450 CYP3A Inhibitors Phase 2
21 Cytochrome P-450 Enzyme Inhibitors Phase 2
22 Folic Acid Antagonists Phase 2
23 Protective Agents Phase 2
24 Vitamin B Complex Phase 2
25 Antibodies Phase 1, Phase 2
26 gamma-Globulins Phase 1, Phase 2
27 Immunoglobulins Phase 1, Phase 2
28 Immunoglobulins, Intravenous Phase 1, Phase 2
29 Pharmaceutical Solutions Phase 1, Phase 2
30 Rho(D) Immune Globulin Phase 1, Phase 2
31 Folate Nutraceutical Phase 2
32 Vitamin B9 Nutraceutical Phase 2
33
Clindamycin Approved, Vet_approved 18323-44-9 29029
34 Clindamycin palmitate
35 Clindamycin phosphate

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir Completed NCT00031486 Phase 3 Valacyclovir;Placebo
2 Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Completed NCT00000794 Phase 2 Sulfadiazine;Clarithromycin;Atovaquone;Pyrimethamine;Leucovorin calcium
3 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
4 Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) Terminated NCT00746941 Phase 1, Phase 2 mefloquine
5 A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS Completed NCT00000674 Pyrimethamine;Leucovorin calcium;Clindamycin

Search NIH Clinical Center for St. Louis Encephalitis

Cochrane evidence based reviews: encephalitis, st. louis

Genetic Tests for St. Louis Encephalitis

Anatomical Context for St. Louis Encephalitis

MalaCards organs/tissues related to St. Louis Encephalitis:

39
Brain, Testes, Kidney, Thyroid, Salivary Gland, Pituitary

Publications for St. Louis Encephalitis

Articles related to St. Louis Encephalitis:

(show top 50) (show all 416)
id Title Authors Year
1
St. Louis encephalitis virus possibly transmitted through blood transfusion-Arizona, 2015. ( 28905395 )
2017
2
Mutagen resistance and mutation restriction of St. Louis encephalitis virus. ( 28284278 )
2017
3
Neuroinvasive St. Louis Encephalitis Virus Infection in Solid Organ Transplant Recipients. ( 28452107 )
2017
4
Diagnosis of Fatal Human Case of St. Louis Encephalitis Virus Infection by Metagenomic Sequencing, California, 2016. ( 28930022 )
2017
5
Toxicity of ar-curcumene and epi-I^-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors. ( 27918946 )
2017
6
Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses Using Reverse Transcription Loop-Mediated Isothermal Amplification. ( 26807734 )
2016
7
Astrocyte response to St. Louis encephalitis virus. ( 26975980 )
2016
8
Reemergence of St. Louis Encephalitis Virus, California, 2015. ( 27869600 )
2016
9
Mutagen resistance and mutation restriction of St. Louis encephalitis virus. ( 27959789 )
2016
10
Widespread Detection of Antibodies to Eastern Equine Encephalitis, West Nile, St. Louis Encephalitis, and Turlock Viruses in Various Species of Wild Birds from Across the United States. ( 27162269 )
2016
11
Activity Patterns of St. Louis Encephalitis and West Nile Viruses in Free Ranging Birds during a Human Encephalitis Outbreak in Argentina. ( 27564679 )
2016
12
First genome sequence of St. Louis encephalitis virus (SLEV) isolated from a human in Brazil. ( 25740285 )
2015
13
Multiplex qRT-PCR for the Detection of Western Equine Encephalomyelitis, St. Louis Encephalitis, and West Nile Viral RNA in Mosquito Pools (Diptera: Culicidae). ( 26334826 )
2015
14
Exploring Genomic, Geographic and Virulence Interactions among Epidemic and Non-Epidemic St. Louis Encephalitis Virus (Flavivirus) Strains. ( 26312485 )
2015
15
Concurrent Outbreaks of St. Louis Encephalitis Virus and West Nile Virus Disease - Arizona, 2015. ( 26656306 )
2015
16
St. Louis Encephalitis virus mosquito vectors dynamics in three different environments in relation to remotely sensed environmental conditions. ( 25792419 )
2015
17
West Nile and St. Louis Encephalitis Viruses Antibodies Surveillance in Captive and Free-Ranging Birds of Prey from Argentina. ( 25106849 )
2014
18
Consequences of in vitro host shift for St. Louis encephalitis virus. ( 24643879 )
2014
19
Genetic Determinants of Differential Oral Infection Phenotypes of West Nile and St. Louis Encephalitis Viruses in Culex spp. Mosquitoes. ( 25157120 )
2014
20
St. Louis encephalitis virus infection in woman, Peru. ( 24655897 )
2014
21
West Nile and St. Louis encephalitis viruses. ( 25015498 )
2014
22
Transmission of endemic St Louis encephalitis virus strains by local Culex quinquefasciatus populations in Cordoba, Argentina. ( 23474474 )
2013
23
Seroprevalence of St. Louis encephalitis virus and West Nile virus (Flavivirus, Flaviviridae) in horses, Uruguay. ( 24490165 )
2013
24
Structure of the St. Louis encephalitis virus postfusion envelope trimer. ( 23115296 )
2013
25
Provenance and geographic spread of St. Louis encephalitis virus. ( 23760463 )
2013
26
Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina. ( 22666870 )
2012
27
Molecular evidence of St. Louis encephalitis virus infection in patients in Buenos Aires, Argentina. ( 22608840 )
2012
28
Effects of virus dose and extrinsic incubation temperature on vector competence of Culex nigripalpus (Diptera: Culicidae) for St. Louis encephalitis virus. ( 23270182 )
2012
29
Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes. ( 21940408 )
2012
30
Silent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005). ( 22303490 )
2012
31
Evaluation of widely used diagnostic tests to detect West Nile virus infections in horses previously infected with St. Louis encephalitis virus or dengue virus type 2. ( 21346058 )
2011
32
Seroconversion for West Nile and St. Louis encephalitis viruses among sentinel horses in Colombia. ( 22241119 )
2011
33
Temporal and spatial alterations in mutant swarm size of St. Louis encephalitis virus in mosquito hosts. ( 21215334 )
2011
34
Immunoglobulin G subclasses in antibody responses to St. Louis encephalitis virus infections. ( 21688106 )
2011
35
Vertical transmission of St. Louis encephalitis virus in Culex quinquefasciatus (Diptera: Culicidae) in CA^rdoba, Argentina. ( 20426683 )
2010
36
Mosquito fauna inhabiting water bodies in the urban environment of CA^rdoba city, Argentina, following a St. Louis encephalitis outbreak. ( 21175948 )
2010
37
High throughput quantitative colorimetric microneutralization assay for the confirmation and differentiation of West Nile Virus and St. Louis encephalitis virus. ( 20207881 )
2010
38
Effect of sequential exposure on infection and dissemination rates for West Nile and St. Louis encephalitis viruses in Culex quinquefasciatus. ( 19492941 )
2009
39
Isolation of genotype V St. Louis encephalitis virus in Florida. ( 19331744 )
2009
40
Comparative thermostability of West Nile, St. Louis encephalitis, and western equine encephalomyelitis viruses during heat inactivation for serologic diagnostics. ( 19407138 )
2009
41
Severe winter freezes enhance St. Louis encephalitis virus amplification and epidemic transmission in peninsular Florida. ( 19960704 )
2009
42
Experimental passage of St. Louis encephalitis virus in vivo in mosquitoes and chickens reveals evolutionarily significant virus characteristics. ( 19924238 )
2009
43
Evolution and dispersal of St. Louis encephalitis virus in the Americas. ( 18708161 )
2009
44
Eared dove (Zenaida auriculata, Columbidae) as host for St. Louis encephalitis virus (Flaviviridae, Flavivirus). ( 18429694 )
2008
45
Phylogenetic and evolutionary analyses of St. Louis encephalitis virus genomes. ( 18374605 )
2008
46
Genetic variation of St. Louis encephalitis virus. ( 18632961 )
2008
47
Evaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeys. ( 18586359 )
2008
48
Reliable detection of St. Louis encephalitis virus by RT-nested PCR. ( 18208760 )
2008
49
Persistent West Nile virus transmission and the apparent displacement St. Louis encephalitis virus in southeastern California, 2003-2006. ( 18533445 )
2008
50
A duplex real-time reverse transcriptase polymerase chain reaction assay for the detection of St. Louis encephalitis and eastern equine encephalitis viruses. ( 18715737 )
2008

Variations for St. Louis Encephalitis

Expression for St. Louis Encephalitis

Search GEO for disease gene expression data for St. Louis Encephalitis.

Pathways for St. Louis Encephalitis

Pathways related to St. Louis Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 IFNA2 IFNA8 KRAS RAF1
2 12.33 IFNA2 IFNA8 KRAS RAF1
3
Show member pathways
12.31 IFNA2 IFNA8 NXT1 RAF1
4
Show member pathways
11.94 IFNA2 IFNA8 KRAS RAF1
5 11.86 IFNA2 IFNA8 RAF1
6
Show member pathways
11.82 IFNA2 IFNA8 RAF1
7 11.22 KRAS RAF1
8 11.2 IFNA2 IFNA8 KRAS RAF1
9 11.15 IFNA2 IFNA8
10 11.04 IFNA2 IFNA8 KRAS RAF1
11 10.95 KRAS RAF1
12 10.89 KRAS RAF1
13 10.71 KRAS RAF1
14 10.56 KRAS RAF1

GO Terms for St. Louis Encephalitis

Biological processes related to St. Louis Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA phosphodiester bond hydrolysis GO:0090501 9.46 RNASE1 RNASE3
2 B cell proliferation GO:0042100 9.43 IFNA2 IFNA8
3 response to exogenous dsRNA GO:0043330 9.4 IFNA2 IFNA8
4 regulation of type I interferon-mediated signaling pathway GO:0060338 9.37 IFNA2 IFNA8
5 defense response to virus GO:0051607 9.32 IFNA2 IFNA8
6 T cell activation involved in immune response GO:0002286 9.26 IFNA2 IFNA8
7 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.16 IFNA2 IFNA8
8 cytokine-mediated signaling pathway GO:0019221 9.13 IFNA2 IFNA8 KRAS
9 natural killer cell activation involved in immune response GO:0002323 8.62 IFNA2 IFNA8

Molecular functions related to St. Louis Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ribonuclease activity GO:0004540 9.16 RNASE1 RNASE3
2 cytokine receptor binding GO:0005126 8.96 IFNA2 IFNA8
3 type I interferon receptor binding GO:0005132 8.62 IFNA2 IFNA8

Sources for St. Louis Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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