MCID: STL001
MIFTS: 46

St. Louis Encephalitis malady

Infectious diseases, Neuronal diseases categories

Summaries for St. Louis Encephalitis

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8Disease Ontology, 3CDC, 32MalaCards
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CDC:3 Saint Louis encephalitis virus (SLEV) is transmitted to humans by the bite of an infected mosquito. Most cases of SLEV disease have occurred in eastern and central states (see map). Most persons infected with SLEV have no apparent illness. Initial symptoms of those who become ill include fever, headache, nausea, vomiting, and tiredness. Severe neuroinvasive disease (often involving encephalitis, an inflammation of the brain) occurs more commonly in older adults. In rare cases, long-term disability or death can result. There is no specific treatment for SLEV infection; care is based on symptoms. You can reduce your risk of being infected with SLEV by using insect repellent, wearing protective clothing, and staying indoors while mosquitoes are most active. If you think you or a family member may have SLEV neuroinvasive disease, it is important to consult your healthcare provider for proper diagnosis.

MalaCards: St. Louis Encephalitis, also known as neuroinvasive st. louis encephalitis virus infection, is related to encephalitis and western equine encephalitis, and has symptoms including spastic paralysis, convulsions and tremors. An important gene associated with St. Louis Encephalitis is CD40LG (CD40 ligand), and among its related pathways are Cell adhesion molecules (CAMs) and Allograft rejection. The compounds rottlerin and herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in st. louis encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions and has symptom spastic paralysis.

Aliases & Classifications for St. Louis Encephalitis

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
st. louis encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

st. louis encephalitis 8 10 48
neuroinvasive st. louis encephalitis virus infection 8
saint louis encephalitis 48
encephalitis, st. louis 60


External Ids:

Disease Ontology8 DOID:10845
MeSH34 D004674
ICD9CM27 062.3
MESH via Orphanet35 D004674
ICD10 via Orphanet26 A83.3
SNOMED-CT via Orphanet57 417192005, 417607009
UMLS via Orphanet61 C0014060
ICD1025 A83.3

Related Diseases for St. Louis Encephalitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to St. Louis Encephalitis:



Diseases related to st. louis encephalitis

Clinical Features for St. Louis Encephalitis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • spastic paralysis
  • convulsions
  • tremors
  • coma
  • disorientation
  • stupor
  • neck stiffness
  • high fever
  • headache

Drugs & Therapeutics for St. Louis Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for St. Louis Encephalitis

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Genetic Tests for St. Louis Encephalitis

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Anatomical Context for St. Louis Encephalitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to St. Louis Encephalitis:

32
Brain, Testes, Kidney, Pituitary, Salivary gland, Thyroid

FMA organs/tissues related to St. Louis Encephalitis:

14
Brain

Animal Models for St. Louis Encephalitis or affiliated genes

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Publications for St. Louis Encephalitis

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Sources:
50PubMed
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Articles related to St. Louis Encephalitis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Transmission of endemic St Louis encephalitis virus strains by local Culex quinquefasciatus populations in Cordoba, Argentina. (23474474)
2013
2
Provenance and geographic spread of St. Louis encephalitis virus. (23760463)
2013
3
Genetic variation of St. Louis encephalitis virus. (18632961)
2008
4
Mutation analysis of the fusion domain region of St. Louis encephalitis virus envelope protein. (17157348)
2007
5
Unexpected altered specificity is responsible for St. Louis encephalitis virus recombinant protease autoproteolysis. (17266653)
2007
6
Post-infectious encephalomyelitis associated with St. Louis encephalitis virus infection. (15534266)
2004
7
Evaluation of a diagnostic algorithm using immunoglobulin M enzyme-linked immunosorbent assay to differentiate human West Nile Virus and St. Louis Encephalitis virus infections during the 2002 West Nile Virus epidemic in the United States. (15539517)
2004
8
The neurobehavioural consequences of St. Louis encephalitis infection. (12419004)
2002
9
Temporal and geographic genetic variation in Culex nigripalpus theobald (Culicidae: Diptera), a vector of St. Louis encephalitis virus, from Florida. (12495183)
2002
10
An indirect immunofluorescence assay to detect antibodies against St. Louis Encephalitis virus. (11781605)
2001
11
Simulation studies of St. Louis encephalitis and West Nile viruses: the impact of bird mortality. (12653130)
2001
12
Response of house finches to infection with sympatric and allopatric strains of western equine encephalomyelitis and St. Louis encephalitis viruses from California. (10730497)
2000
13
Role of peridomestic birds in the transmission of St. Louis encephalitis virus in southern California. (10682741)
2000
14
Immunisation with DNA polynucleotides protects mice against lethal challenge with St. Louis encephalitis virus. (8645110)
1996
15
Transmission patterns of St. Louis encephalitis and eastern equine encephalitis viruses in Florida: 1978-1993. (8906917)
1996
16
Antibodies to St. Louis encephalitis virus in armadillos from southern Florida. (7563416)
1995
17
Molecular and biological characterization of a non-glycosylated isolate of St Louis encephalitis virus. (7506301)
1993
18
St Louis encephalitis virus establishes a productive, cytopathic and persistent infection of Sf9 cells. (8345362)
1993
19
Effect of temperature on the transmission of western equine encephalomyelitis and St. Louis encephalitis viruses by Culex tarsalis (Diptera: Culicidae). (8433322)
1993
20
Ecological observations on the 1989 outbreak of St. Louis encephalitis virus in the southern San Joaquin Valley of California. (1625296)
1992
21
Temporal variations in the susceptibility of a semi-isolated population of Culex tarsalis to peroral infection with western equine encephalomyelitis and St. Louis encephalitis viruses. (2160200)
1990
22
The importance of autumn rainfall and sentinel flock location to understanding the epidemiology of St. Louis encephalitis virus in Indian River County, Florida. (2852706)
1985
23
Comparative vector competence of Culex tarsalis and Culex quinquefasciatus from the coachella, imperial, and San Joaquin Valleys of California for St. Louis encephalitis virus. (6301301)
1983
24
Epidemiology of St. Louis encephalitis and other acute encephalitides. (570348)
1978
25
A simple method for the inactivation of St. Louis encephalitis virus preparations for immunofluorescent microscopy. (383247)
1978
26
St. Louis encephalitis in the United States, 1975. (864283)
1977
27
The epidemiology of St. Louis encephalitis in Corpus Christi, Texas, 1966. (1155434)
1975
28
Studies of arthropod-borne virus infections in Chiroptera. 8. Evidence of natural St. Louis encephalitis virus infection in bats. (5453911)
1970
29
Protection against St. Louis encephalitis and West Nile arboviruses by previous dengue virus (types 1-4) infection. (4991402)
1970
30
Stability of St. Louis encephalitis virus in the airborne state. (4984205)
1969
31
The epidemiology of St. Louis encephalitis: a review. (4893404)
1969
32
A review of developments associated with the control of Western Equine and St. Louis encephalitis in California during 1967. (5730061)
1968
33
Heterotypic serologic responses after yellow fever vaccination; detection of persons with past St. Louis encephalitis or dengue. (6022887)
1967
34
The 1962 epidemic of St. Louis encephalitis in Florida. II. Follow-up serologic surveys for prevalence of Group B arbovirus antibodies. (5934623)
1966
35
FOLLOW-UP STUDIES OF ST. LOUIS ENCEPHALITIS IN FLORIDA: HEALTH QUESTIONNAIRE FINDINGS. (14318464)
1965
36
COMMUNITY INFECTION WITH ST. LOUIS ENCEPHALITIS VIRUS. SEROLOGIC STUDY OF THE 1964 EPIDEMIC IN HOUSTON. (14310326)
1965
37
SEROLOGIC EPIDEMIOLOGY OF WESTERN EQUINE AND ST. LOUIS ENCEPHALITIS VIRUS INFECTION IN CALIFORNIA. I. PERSISTENCE OF COMPLEMENT-FIXING ANTIBODY FOLLOWING CLINICAL ILLNESS. (14114351)
1964
38
STUDIES OF ARTHROPOD-BORNE VIRUS INFECTIONS IN CHIROPTERA. I. SUSCEPTIBILITY OF INSECTIVOROUS SPECIES TO EXPERIMENTAL INFECTION WITH JAPANESE B AND ST. LOUIS ENCEPHALITIS VIRUSES. (14070775)
1963
39
Comparison of hamster kidney and chick embryo tissue cultures with mice for primary isolation of western equine and St. Louis encephalitis viruses. (13910061)
1962
40
Lower Rio Grande valley outbreak of St. Louis encephalitis. (13835654)
1959
41
The multiplication of St. Louis encephalitis virus in two species of mosquitoes: Culex quinque-fasciatus Say and Culex pipiens Linnaeus. (13835549)
1959
42
St. Louis encephalitis in Panama. I. Isolation of the virus from forest mosquitoes and human blood. (13826059)
1959
43
Transplacental passage of antibody to western equine and St. Louis encephalitis viruses. (13670369)
1959
44
Challenge of hamsters with Japanese B, St. Louis and Murray Valley encephalitis viruses after immunization by West Nile infection plus specific vaccine. (13481371)
1957
45
Virus of ST. Louis encephalitis in three species of wild birds. (13402751)
1957
46
The hemagglutinin of St. Louis encephalitis virus. III. Properties of normal inhibitors and specific antibody; use of hemagglutination-inhibition for diagnosis of infection. (13035120)
1953
47
Isolation of St. Louis encephalitis virus from a fatal human case in California. (21024144)
1946
48
St. Louis encephalitis virus in the blood of experimentally inoculated fowls and mammals. (21016310)
1946
49
Persistence of the Virus of St. Louis Encephalitis in the Central Nervous System of Mice for Over Five Months. (16560683)
1943
50
JAPANESE B ENCEPHALITIS VIRUS: ITS DIFFERENTIATION FROM ST. LOUIS ENCEPHALITIS VIRUS AND RELATIONSHIP TO LOUPING ILL VIRUS. (19870743)
1938

Genetic Variations for St. Louis Encephalitis

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Expression for genes affiliated with St. Louis Encephalitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with St. Louis Encephalitis

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Pathways for genes affiliated with St. Louis Encephalitis

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Sources:
29KEGG, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with St. Louis Encephalitis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rottlerin449.5RAF1, CD40LG
2herbimycin a44 5910.5RAF1, CD40LG
3rituximab44 49 1111.4RAF1, CD40LG
4theophylline44 28 11 2412.2RAF1, CD40LG

GO Terms for genes affiliated with St. Louis Encephalitis

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16Gene Ontology
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Molecular functions related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2CD40LG, IFNA8

Products for genes affiliated with St. Louis Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for St. Louis Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet