MCID: STL001
MIFTS: 52

St. Louis Encephalitis malady

Infectious diseases, Neuronal diseases, Rare diseases categories
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Summaries for St. Louis Encephalitis

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CDC:3 Saint Louis encephalitis virus (SLEV) is transmitted to humans by the bite of an infected mosquito. Most cases of SLEV disease have occurred in eastern and central states (see map). Most persons infected with SLEV have no apparent illness. Initial symptoms of those who become ill include fever, headache, nausea, vomiting, and tiredness. Severe neuroinvasive disease (often involving encephalitis, an inflammation of the brain) occurs more commonly in older adults. In rare cases, long-term disability or death can result. There is no specific treatment for SLEV infection; care is based on symptoms. You can reduce your risk of being infected with SLEV by using insect repellent, wearing protective clothing, and staying indoors while mosquitoes are most active. If you think you or a family member may have SLEV neuroinvasive disease, it is important to consult your healthcare provider for proper diagnosis.

MalaCards based summary: St. Louis Encephalitis, also known as neuroinvasive st. louis encephalitis virus infection, is related to encephalitis and west nile virus, and has symptoms including An important gene associated with St. Louis Encephalitis is CD40LG (CD40 ligand), and among its related pathways are Allograft rejection and Influenza A. The compounds rottlerin and rituximab have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in st. louis encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions and has symptom spastic paralysis.

Aliases & Classifications for St. Louis Encephalitis

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

St. Louis Encephalitis, Aliases & Descriptions:

Name: St. Louis Encephalitis 8 10 48
Neuroinvasive St. Louis Encephalitis Virus Infection 8 62
 
Saint Louis Encephalitis 48 62
Encephalitis, St. Louis 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
st. louis encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:10845
MeSH34 D004674
ICD9CM27 062.3
MESH via Orphanet35 D004674
ICD10 via Orphanet26 A83.3
UMLS via Orphanet63 C0014060
ICD1025 A83.3

Related Diseases for St. Louis Encephalitis

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Graphical network of the top 20 diseases related to St. Louis Encephalitis:



Diseases related to st. louis encephalitis

Symptoms for St. Louis Encephalitis

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Drugs & Therapeutics for St. Louis Encephalitis

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Drug clinical trials:

Search ClinicalTrials for St. Louis Encephalitis

Search NIH Clinical Center for St. Louis Encephalitis

Genetic Tests for St. Louis Encephalitis

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Anatomical Context for St. Louis Encephalitis

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MalaCards organs/tissues related to St. Louis Encephalitis:

32
Brain, Testes, Kidney, Thyroid, Salivary gland, Pituitary

FMA organs/tissues related to St. Louis Encephalitis:

14
Brain

Animal Models for St. Louis Encephalitis or affiliated genes

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Publications for St. Louis Encephalitis

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Articles related to St. Louis Encephalitis:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
West Nile and St. Louis encephalitis viruses. (25015498)
2014
2
Genetic Determinants of Differential Oral Infection Phenotypes of West Nile and St. Louis Encephalitis Viruses in Culex spp. Mosquitoes. (25157120)
2014
3
Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes. (21940408)
2012
4
Silent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005). (22303490)
2012
5
Temporal and spatial alterations in mutant swarm size of St. Louis encephalitis virus in mosquito hosts. (21215334)
2011
6
Evolution and dispersal of St. Louis encephalitis virus in the Americas. (18708161)
2009
7
Persistent West Nile virus transmission and the apparent displacement St. Louis encephalitis virus in southeastern California, 2003-2006. (18533445)
2008
8
A duplex real-time reverse transcriptase polymerase chain reaction assay for the detection of St. Louis encephalitis and eastern equine encephalitis viruses. (18715737)
2008
9
Construction of yellow fever/St. Louis encephalitis chimeric virus and the use of chimeras as a diagnostic tool. (15569798)
2004
10
Serologic evidence of West Nile virus and St. Louis encephalitis virus infections in white-tailed deer (Odocoileus virginianus) from New Jersey, 2001. (15671740)
2004
11
Wild terrestrial rainforest mammals as potential reservoirs for flaviviruses (yellow fever, dengue 2 and St Louis encephalitis viruses) in French Guiana. (15138077)
2004
12
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. (12958248)
2003
13
The neurobehavioural consequences of St. Louis encephalitis infection. (12419004)
2002
14
Viremia and serological responses in adult chickens infected with western equine encephalomyelitis and St. Louis encephalitis viruses. (7707063)
1994
15
Comparison of chickens and pheasants as sentinels for eastern equine encephalitis and St. Louis encephalitis viruses in Florida. (7707062)
1994
16
Preliminary studies of Aedes bahamensis as a host and potential vector of St. Louis encephalitis virus. (2045810)
1991
17
Distribution of St. Louis encephalitis viral antibody in sentinel chickens maintained in Sarasota County, Florida: 1978-1988. (2033613)
1991
18
Vertical transmission of St. Louis encephalitis virus to autogenously developed eggs of Aedes atropalpus mosquitoes. (2098473)
1990
19
Surveillance of St. Louis encephalitis virus vectors in Grand Junction, Colorado, in 1987. (2746202)
1989
20
Antibody prevalence of St. Louis encephalitis virus in avian hosts in Los Angeles, California, 1986. (2852209)
1988
21
Entomologic studies after a St. Louis encephalitis epidemic in Grand Junction, Colorado. (2899394)
1988
22
Epidemiological aspects of a St. Louis encephalitis outbreak in Harris County, Texas, 1986. (2891777)
1988
23
Establishment and characterization of St Louis encephalitis virus persistent infections in Aedes and Culex mosquito cell lines. (2842432)
1988
24
Epidemiologic aspects of a St. Louis encephalitis outbreak in Mesa County, Colorado. (2887107)
1987
25
Serologic evidence for widespread infection with La Crosse and St. Louis encephalitis viruses in the Indiana human population. (6328975)
1984
26
Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)
1981
27
Transovarial transmission of St. Louis encephalitis virus by Culex pipiens complex mosquitoes. (6266266)
1981
28
Transmission of St. Louis encephalitis virus from Argentina by mosquitoes of the Culex pipiens (Diptera: Culicidae) complex. (7401124)
1980
29
Geographic variation among St. Louis encephalitis virus strains in the viremic responses of avian hosts. (7446828)
1980
30
Epidemiology of St. Louis encephalitis and other acute encephalitides. (570348)
1978
31
The epidemiology of St. Louis encephalitis in Dallas, Texas, 1966. (1155433)
1975
32
Recurrent St. Louis encephalitis infection in residents of a flood plain of the Trinity River, Roosevelt Heights (Dallas, Texas). (5048980)
1972
33
Economic cost of St. Louis encephalitis epidemic in Dallas, Texas, 1966. (4971084)
1968
34
Preparation of inactivated St. Louis encephalitis virus vaccine from hamster kidney cell culture. (5924439)
1966
35
St. Louis encephalitis: age aspects of 1962 epidemic in Pinellas County, Florida. (5931332)
1966
36
Follow-up studies of St. Louis encephalitis in Florida: serologic findings eighteen months to five years after epidemics. (4379099)
1966
37
ST. LOUIS ENCEPHALITIS IN CHILDREN DURING THE 1964 EPIDEMIC. (14313895)
1965
38
ISOLATIONS OF ST. LOUIS ENCEPHALITIS VIRUS FROM DOMESTIC PIGEONS, COLUMBA LIVIA. (14159988)
1964
39
ST. LOUIS ENCEPHALITIS IN PANAMA: A REVIEW AND A PROGRESS REPORT. (14162903)
1964
40
THE FIRST ISOLATION OF ST. LOUIS ENCEPHALITIS VIRUS FROM MOSQUITOES IN FLORIDA. (14232042)
1964
41
STUDIES OF ARTHROPOD-BORNE VIRUS INFECTIONS IN CHIROPTERA. I. SUSCEPTIBILITY OF INSECTIVOROUS SPECIES TO EXPERIMENTAL INFECTION WITH JAPANESE B AND ST. LOUIS ENCEPHALITIS VIRUSES. (14070775)
1963
42
Lower Rio Grande valley outbreak of St. Louis encephalitis. (13835654)
1959
43
St. Louis encephalitis in 1933; observations on epidemiological features. (13542726)
1958
44
The relationship of the epidemic keratoconjunctivitis virus of Sanders to the St. Louis encephalitis virus. (13411133)
1957
45
Polyradiculopathy in man produced by St. Louis encephalitis virus (SLE). (13076770)
1953
46
The hemagglutinin of St. Louis encephalitis virus. I. Recovery of stable hemagglutinin from the brains of infected mice. (13035118)
1953
47
A possible relationship between viruses of St. Louis encephalitis and epidemic keratoconjunctivitis. (14844416)
1951
48
Isolation of St. Louis encephalitis virus from a fatal human case in California. (21024144)
1946
49
Persistence of the Virus of St. Louis Encephalitis in the Central Nervous System of Mice for Over Five Months. (16560683)
1943
50
Changes Produced in the Central Nervous System of the Mouse by the Virus of St. Louis Encephalitis. (19970185)
1934

Variations for St. Louis Encephalitis

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Expression for genes affiliated with St. Louis Encephalitis

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Expression patterns in normal tissues for genes affiliated with St. Louis Encephalitis

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Pathways for genes affiliated with St. Louis Encephalitis

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Pathways related to St. Louis Encephalitis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3IFNA8, CD40LG
2
Show member pathways
9.1RAF1, IFNA8
3
Show member pathways
9.1RAF1, IFNA8
49.1IFNA8, RAF1
5
Show member pathways
9.1RAF1, IFNA8
6
Show member pathways
9.1RAF1, IFNA8
79.1RAF1, IFNA8
8
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1RAF1, IFNA8
99.1RAF1, IFNA8
10
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1RAF1, IFNA8
11
Show member pathways
Immune response CD16 signaling in NK cells60
9.1RAF1, IFNA8
12
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.0RAF1, CD40LG
13
Show member pathways
9.0CD40LG, RAF1
14
Show member pathways
8.5CD40LG, RAF1, IFNA8

Compounds for genes affiliated with St. Louis Encephalitis

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Compounds related to St. Louis Encephalitis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1rottlerin449.4CD40LG, RAF1
2rituximab44 50 1111.4CD40LG, RAF1
3theophylline44 28 24 1112.4RAF1, CD40LG
4herbimycin a44 6110.4CD40LG, RAF1
5phosphatidylserine44 28 1111.4CD40LG, RAF1
6vitamin a44 24 1111.4RAF1, CD40LG
7aspirin44 50 28 2412.3CD40LG, RAF1
8agar449.3CD40LG, RAF1
9n acetylcysteine449.3RAF1, CD40LG
10ascorbic acid44 2410.3CD40LG, RAF1
11indomethacin44 28 61 1112.3CD40LG, RAF1
12histamine44 28 2411.3RAF1, CD40LG
13acetylcholine44 50 28 24 1113.3CD40LG, RAF1
14rapamycin449.3CD40LG, RAF1
15doxorubicin44 50 1111.2RAF1, CD40LG
16genistein44 28 61 2 24 1114.2CD40LG, RAF1
17cyclosporin a44 28 6111.2CD40LG, RAF1
18pge2449.1RAF1, CD40LG
19dopamine44 28 24 1112.1CD40LG, RAF1
20cisplatin44 50 61 1112.0CD40LG, RAF1
21testosterone44 61 24 1112.0CD40LG, RAF1
22aspartate448.9RAF1, CD40LG
23heparin44 28 24 1111.7CD40LG, RAF1

GO Terms for genes affiliated with St. Louis Encephalitis

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Biological processes related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:0421009.4CD40LG, IFNA8
2B cell differentiationGO:0301839.4CD40LG, IFNA8
3innate immune responseGO:0450879.1RAF1, IFNA8
4platelet activationGO:0301689.0CD40LG, RAF1
5negative regulation of apoptotic processGO:0430668.9RAF1, CD40LG
6blood coagulationGO:0075968.8IFNA8, RAF1

Molecular functions related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.3CD40LG, IFNA8

Products for genes affiliated with St. Louis Encephalitis

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  • Antibodies
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Sources for St. Louis Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet