MCID: STL001
MIFTS: 46

St. Louis Encephalitis malady

Infectious diseases, Neuronal diseases categories

Summaries for St. Louis Encephalitis

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8Disease Ontology, 3CDC, 32MalaCards
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CDC:3 Saint Louis encephalitis virus (SLEV) is transmitted to humans by the bite of an infected mosquito. Most cases of SLEV disease have occurred in eastern and central states (see map). Most persons infected with SLEV have no apparent illness. Initial symptoms of those who become ill include fever, headache, nausea, vomiting, and tiredness. Severe neuroinvasive disease (often involving encephalitis, an inflammation of the brain) occurs more commonly in older adults. In rare cases, long-term disability or death can result. There is no specific treatment for SLEV infection; care is based on symptoms. You can reduce your risk of being infected with SLEV by using insect repellent, wearing protective clothing, and staying indoors while mosquitoes are most active. If you think you or a family member may have SLEV neuroinvasive disease, it is important to consult your healthcare provider for proper diagnosis.

MalaCards: St. Louis Encephalitis, also known as neuroinvasive st. louis encephalitis virus infection, is related to encephalitis and western equine encephalitis, and has symptoms including spastic paralysis, convulsions and tremors. An important gene associated with St. Louis Encephalitis is CD40LG (CD40 ligand), and among its related pathways are Cell adhesion molecules (CAMs) and Allograft rejection. The compounds rottlerin and herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in st. louis encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions and has symptom spastic paralysis.

Aliases & Classifications for St. Louis Encephalitis

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
st. louis encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

st. louis encephalitis 8 10 48
neuroinvasive st. louis encephalitis virus infection 8
saint louis encephalitis 48
encephalitis, st. louis 60


External Ids:

Disease Ontology8 DOID:10845
MeSH34 D004674
ICD9CM27 062.3
MESH via Orphanet35 D004674
ICD10 via Orphanet26 A83.3
SNOMED-CT via Orphanet57 417192005, 417607009
UMLS via Orphanet61 C0014060
ICD1025 A83.3

Related Diseases for St. Louis Encephalitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to St. Louis Encephalitis:



Diseases related to st. louis encephalitis

Clinical Features for St. Louis Encephalitis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • spastic paralysis
  • convulsions
  • tremors
  • coma
  • disorientation
  • stupor
  • neck stiffness
  • high fever
  • headache

Drugs & Therapeutics for St. Louis Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for St. Louis Encephalitis

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Anatomical Context for St. Louis Encephalitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to St. Louis Encephalitis:

32
Brain, Testes, Kidney, Pituitary, Salivary gland, Thyroid

FMA organs/tissues related to St. Louis Encephalitis:

14
Brain

Animal Models for St. Louis Encephalitis or affiliated genes

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Publications for St. Louis Encephalitis

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Sources:
50PubMed
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Articles related to St. Louis Encephalitis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Effects of virus dose and extrinsic incubation temperature on vector competence of Culex nigripalpus (Diptera: Culicidae) for St. Louis encephalitis virus. (23270182)
2012
2
Human outbreak of St. Louis encephalitis detected in Argentina, 2005. (18249032)
2008
3
St. Louis encephalitis in early infancy. (15602196)
2004
4
Predicting St. Louis encephalitis virus epidemics: lessons from recent, and not so recent, outbreaks. (11112165)
2001
5
St Louis encephalitis: a review of 11 cases in a 1995 Dallas, Tex, epidemic. (10634457)
2000
6
Landscape ecology of arboviruses in southern California: patterns in the epizootic dissemination of western equine encephalomyelitis and St. Louis encephalitis viruses in Coachella Valley, 1991-1992. (7616516)
1995
7
Isolation of St. Louis encephalitis virus from a killer whale. (15566723)
1993
8
Detection of St. Louis encephalitis virus in mosquitoes by use of the polymerase chain reaction. (1383418)
1992
9
St. Louis encephalitis in Arkansas. (1517179)
1992
10
Distribution of St. Louis encephalitis viral antibody in sentinel chickens maintained in Sarasota County, Florida: 1978-1988. (2033613)
1991
11
St. Louis encephalitis outbreak--Arkansas, 1991. (1881382)
1991
12
Antibody prevalence of St. Louis encephalitis virus in avian hosts in Los Angeles, California, 1986. (2852209)
1988
13
The St. Louis encephalitis epidemic. (2839532)
1988
14
Epidemiologic aspects of a St. Louis encephalitis outbreak in Mesa County, Colorado. (2887107)
1987
15
St. Louis encephalitis: lessons from the last decade. (3318523)
1987
16
Immunoglobulin M antibody capture enzyme-linked immunosorbent assay for diagnosis of St. Louis encephalitis. (6386882)
1984
17
The house sparrow (Passer domesticus) as a sentinel for St. Louis encephalitis virus. (6312819)
1983
18
St. Louis encephalitis virus temperature-sensitive mutants. I. Induction, isolation and preliminary characterization. (6188441)
1983
19
Reservoir of St. Louis encephalitis virus in Ohio bats. (6638648)
1983
20
Experimental St. Louis encephalitis virus infection of sloths and cormorants. (6881434)
1983
21
Opsoclonus in a confirmed case of St. Louis encephalitis. (7119837)
1982
22
Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)
1981
23
Transovarial transmission of St. Louis encephalitis virus by Culex pipiens complex mosquitoes. (6266266)
1981
24
St. Louis encephalitis: a comparison of two epidemics in Harris county, Texas. (6109458)
1981
25
Evaluation of the solid-phase radioimmunoassay for diagnosis of St. Louis encephalitis infection in humans. (6168650)
1981
26
St Louis encephalitis. Quantitative histologic and immunofluorescent studies. (7016088)
1981
27
St. Louis encephalitis. (398269)
1979
28
St. Louis encephalitis epidemic in Ohio in 1975. (704005)
1978
29
Isolation of St. Louis encephalitis virus from overwintering Culex pipiens mosquitoes. (628843)
1978
30
Serologic survey for St. Louis encephalitis and other group B arbovirus antibodies in residents of Houston, Texas. (5415579)
1970
31
St. Louis encephalitis and dengue fever in the Caribbean area: evidence of possible cross-protection. (5306318)
1969
32
Susceptibility of dogs to St. Louis encephalitis and other selected arthropod-borne viruses. (5816366)
1969
33
Isolation of St. Louis encephalitis virus from a naturally-infected gray fox Urocyon cinereoargenteus. (6028561)
1967
34
Follow-up studies of St. Louis encephalitis in Florida: comparison of 1964 and 1965 health questionnaire findings. (5928083)
1966
35
The 1962 epidemic of St. Louis encephalitis in Florida. V. Serologic diagnosis of cases. (5910219)
1966
36
St. Louis encephalitis. (5178690)
1966
37
ST. LOUIS ENCEPHALITIS VIRUS IN JAMAICAN BIRDS. (14270457)
1965
38
ST. LOUIS ENCEPHALITIS IN ADULTS DURING THE 1964 HOUSTON EPIDEMIC. (14310350)
1965
39
ST. LOUIS ENCEPHALITIS. (14304360)
1965
40
Use of chicks for detecting western equine and St. Louis encephalitis viruses in mosquitoes. (13715234)
1960
41
St. Louis encephalitis virus in mosquitoes. (13809061)
1959
42
Comparison of diagnostic methods for western equine and St. Louis encephalitis. (18132342)
1949
43
Isolation From Wild Bird Mites (Liponyssus sylviarum) of a Virus or Mixture of Viruses From Which St. Louis and Western Equine Encephalitis Viruses Have Been Obtained. (17735538)
1948
44
Epidemiological studies on Western equine encephalomyelitis and St. Louis encephalitis in Oklahoma, 1944. (20266921)
1947
45
pH stability of St. Louis encephalitis virus. (20277740)
1946
46
ST. LOUIS ENCEPHALITIS : INFECTION OF CHICKEN MITES, DERMANYSSUS GALLINAE, BY FEEDING ON CHICKENS WITH VIREMIA; TRANSOVARIAN PASSAGE OF VIRUS INTO THE SECOND GENERATION. (19871548)
1946
47
THE ISOLATION OF THE ST. LOUIS ENCEPHALITIS VIRUS FROM CHICKEN MITES (DERMANYSSUS GALLINAE) IN NATURE. (17835066)
1944
48
RELATION BETWEEN DEGREE OF IMMUNITY OF MICE FOLLOWING VACCINATION WITH ST. LOUIS ENCEPHALITIS VIRUS AND THE TITRE OF THE PROTECTIVE ANTIBODIES OF THE SERUM. (19870787)
1938
49
JAPANESE B ENCEPHALITIS VIRUS: ITS DIFFERENTIATION FROM ST. LOUIS ENCEPHALITIS VIRUS AND RELATIONSHIP TO LOUPING-ILL VIRUS. (17832643)
1937
50
Changes Produced in the Central Nervous System of the Mouse by the Virus of St. Louis Encephalitis. (19970185)
1934

Genetic Variations for St. Louis Encephalitis

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Expression for genes affiliated with St. Louis Encephalitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with St. Louis Encephalitis

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Pathways for genes affiliated with St. Louis Encephalitis

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Sources:
29KEGG, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with St. Louis Encephalitis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rottlerin449.5RAF1, CD40LG
2herbimycin a44 5910.5RAF1, CD40LG
3rituximab44 49 1111.4RAF1, CD40LG
4theophylline44 28 11 2412.2RAF1, CD40LG

GO Terms for genes affiliated with St. Louis Encephalitis

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16Gene Ontology
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Molecular functions related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2CD40LG, IFNA8

Products for genes affiliated with St. Louis Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for St. Louis Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet