MCID: STL001
MIFTS: 37

St. Louis Encephalitis malady

Infectious, Neuronal categories

Summaries for St. Louis Encephalitis

Sources:
8Disease Ontology, 3CDC, 33MalaCards
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CDC:3 Saint Louis encephalitis virus (SLEV) is transmitted to humans by the bite of an infected mosquito. Most cases of SLEV disease have occurred in eastern and central states (see map). Most persons infected with SLEV have no apparent illness. Initial symptoms of those who become ill include fever, headache, nausea, vomiting, and tiredness. Severe neuroinvasive disease (often involving encephalitis, an inflammation of the brain) occurs more commonly in older adults. In rare cases, long-term disability or death can result. There is no specific treatment for SLEV infection; care is based on symptoms. You can reduce your risk of being infected with SLEV by using insect repellent, wearing protective clothing, and staying indoors while mosquitoes are most active. If you think you or a family member may have SLEV neuroinvasive disease, it is important to consult your healthcare provider for proper diagnosis.

MalaCards: St. Louis Encephalitis, also known as neuroinvasive st. louis encephalitis virus infection, is related to western equine encephalitis and west nile encephalitis, and has symptoms including headache, convulsions and coma. An important gene associated with St. Louis Encephalitis is CD40LG (CD40 ligand), and among its related pathways are Cell adhesion molecules (CAMs) and Allograft rejection. The compounds rottlerin and herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and kidney.

Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in st. louis encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions and has symptom spastic paralysis.

Aliases & Classifications for St. Louis Encephalitis

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
st. louis encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

st. louis encephalitis 8 10 49
neuroinvasive st. louis encephalitis virus infection 8
saint louis encephalitis 49
encephalitis, st. louis 61


External Ids:

Disease Ontology8 DOID:10845
MeSH35 D004674
ICD9CM27 062.3
MESH via Orphanet36 D004674
ICD10 via Orphanet26 A83.3
SNOMED-CT via Orphanet58 417192005, 417607009
UMLS via Orphanet62 C0014060
ICD1025 A83.3

Related Diseases for St. Louis Encephalitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to St. Louis Encephalitis:



Diseases related to st. louis encephalitis

Clinical Features for St. Louis Encephalitis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 9)
  • headache
  • convulsions
  • coma
  • tremors
  • neck stiffness
  • high fever
  • stupor
  • disorientation
  • spastic paralysis

Drugs & Therapeutics for St. Louis Encephalitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for St. Louis Encephalitis

Drug clinical trials:

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Genetic Tests for St. Louis Encephalitis

Anatomical Context for St. Louis Encephalitis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to St. Louis Encephalitis:

33
Brain, Kidney, B cells

FMA organs/tissues related to St. Louis Encephalitis:

14
Brain

Animal Models for St. Louis Encephalitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for St. Louis Encephalitis

Sources:
51PubMed
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Articles related to St. Louis Encephalitis:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Transmission of endemic St Louis encephalitis virus strains by local Culex quinquefasciatus populations in Cordoba, Argentina. (23474474)
2013
2
Structure of the St. Louis encephalitis virus postfusion envelope trimer. (23115296)
2013
3
Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes. (21940408)
2012
4
St. Louis encephalitis virus: first isolation from a human in SALo Paulo State, Brazil. (16302112)
2005
5
Evaluation of a diagnostic algorithm using immunoglobulin M enzyme-linked immunosorbent assay to differentiate human West Nile Virus and St. Louis Encephalitis virus infections during the 2002 West Nile Virus epidemic in the United States. (15539517)
2004
6
Age-related seroprevalence study for St. Louis encephalitis in a population from Cordoba, Argentina. (12048540)
2002
7
Simulation studies of St. Louis encephalitis virus in south Florida. (12653129)
2001
8
Response of house finches to infection with sympatric and allopatric strains of western equine encephalomyelitis and St. Louis encephalitis viruses from California. (10730497)
2000
9
Vector competence of Aedes albopictus from Pine Bluff, Arkansas, for a St. Louis encephalitis virus strain isolated during the 1991 epidemic. (7707054)
1994
10
Preliminary studies of Aedes bahamensis as a host and potential vector of St. Louis encephalitis virus. (2045810)
1991
11
Experimental studies to determine the susceptibility to infection with St. Louis encephalitis virus of five species of Panamanian mosquitoes. (1686273)
1991
12
Arboviral surveillance. Update: St. Louis encephalitis in Florida and Texas, United States, 1990. (2276208)
1990
13
Stability of St. Louis encephalitis viral antigen detected by enzyme immunoassay in infected mosquitoes. (2852675)
1988
14
Partial nucleotide sequence of St. Louis encephalitis virus RNA: structural proteins, NS1, ns2a, and ns2b. (3027980)
1987
15
Purification of the structural and nonstructural proteins of St. Louis encephalitis virus. (6099371)
1984
16
Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)
1981
17
St Louis encephalitis. Quantitative histologic and immunofluorescent studies. (7016088)
1981
18
Variation among strains of St. Louis encephalitis virus: basis for a genetic, pathogenetic, and epidemiologic classification. (6261645)
1980
19
Variation in virulence for mice and rhesus monkeys among St. Louis encephalitis virus strains of different origin. (6254384)
1980
20
St Louis encephalitis with particular involvement of the brain stem. (413533)
1978
21
Replication of eastern equine encephalitis viruses (New Jersey and Louisiana strains and the Ets-4 mutant) in rabbit kidney cells. (1170829)
1975
22
Virological studies of avian hosts in the Houston epidemic of St. Louis encephalitis, 1964. (4729745)
1973
23
St. Louis encephalitis virus: an ultrastructural study of infection in a mosquito vector. (4583310)
1973
24
Epidemiologic studies of possible cross protection between dengue and St. Louis encephalitis arboviruses in Florida. (4394396)
1970
25
Studies of arthropod-borne virus infections in Chiroptera. 8. Evidence of natural St. Louis encephalitis virus infection in bats. (5453911)
1970
26
Stability of St. Louis encephalitis virus in the airborne state. (4984205)
1969
27
The 1964 outbreak of St. Louis encephalitis in the Delaware Valey. 2. Laboratory studies of cases and serologic diagnostic procedures. (4968057)
1968
28
Follow-up studies of St. Louis encephalitis in Florida: serologic findings eighteen months to five years after epidemics. (4379099)
1966
29
Follow-up studies of St. Louis encephalitis in Florida: comparison of 1964 and 1965 health questionnaire findings. (5928083)
1966
30
St. Louis encephalitis. A histopathologic study of the fatal cases from the Houston epidemic in 1964. (5900447)
1966
31
Studies of arthropod-borne virus infections in Chiroptera. 3. Influence of environmental temperature on experimental infection with Japanese B and St. Louis encephalitis viruses. (4287167)
1966
32
Follow-up studies of st. Louis encephalitis in Florida: sensorimotor findings. (18018138)
1966
33
Experimental vector studies with strains of St. Louis encephalitis virus isolated from mosquitoes during the 1964 epidemics. (5986746)
1966
34
EPIDEMIC ST. LOUIS ENCEPHALITIS IN HOUSTON, 1964: A COOPERATIVE STUDY. (14304357)
1965
35
FOLLOW-UP STUDIES OF ST. LOUIS ENCEPHALITIS IN FLORIDA: HEALTH QUESTIONNAIRE FINDINGS. (14318464)
1965
36
COMMUNITY INFECTION WITH ST. LOUIS ENCEPHALITIS VIRUS. SEROLOGIC STUDY OF THE 1964 EPIDEMIC IN HOUSTON. (14310326)
1965
37
STUDIES ON TRANSOVARIAL TRANSMISSION OF ST. LOUIS ENCEPHALITIS VIRUS BY CULEX QUINQUEFASCIATUS SAY. (14215836)
1964
38
VECTOR STUDIES IN THE ST. LOUIS ENCEPHALITIS EPIDEMIC, TAMPA BAY AREA, FLORIDA, 1962. (14159985)
1964
39
STUDIES OF ARTHROPOD-BORNE VIRUS INFECTIONS IN CHIROPTERA. I. SUSCEPTIBILITY OF INSECTIVOROUS SPECIES TO EXPERIMENTAL INFECTION WITH JAPANESE B AND ST. LOUIS ENCEPHALITIS VIRUSES. (14070775)
1963
40
Trans-stadial passage of St. Louis encephalitis virus in Aedes aegypti mosquitoes. (13880621)
1962
41
St. Louis encephalitis in Calvert City, Kentucky, 1955; an epidemiologic study. (13410906)
1957
42
Studies on mites as vectors of western equine and St. Louis encephalitis viruses in California. (13228852)
1955
43
The hemagglutinin of St. Louis encephalitis virus. I. Recovery of stable hemagglutinin from the brains of infected mice. (13035118)
1953
44
The effect of chemical substances in mice infected with St. Louis encephalitis, PR8 strain of influenza, or the lansing strain of poliomyelitis virus. (14938551)
1952
45
Epidemiological studies on Western equine encephalomyelitis and St. Louis encephalitis in Oklahoma, 1944. (20266921)
1947
46
INFLUENCE OF ANESTHESIA ON EXPERIMENTAL NEUROTROPIC VIRUS INFECTIONS : II. IN VITRO STUDIES WITH THE VIRUSES OF WESTERN AND EASTERN EQUINE ENCEPHALOMYELITIS, ST. LOUIS ENCEPHALITIS, POLIOMYELITIS (LANSING), AND RABIES. (19871636)
1947
47
pH stability of St. Louis encephalitis virus. (20277740)
1946
48
Passive protection of the central nervous system of mice against viruses that pursue the pathway of the olfactory nerves after intranasal instillation; vesicular stomatitis and St. Louis encephalitis. (21000279)
1946
49
INFLUENCE OF ANESTHESIA ON EXPERIMENTAL NEUROTROPIC VIRUS INFECTIONS : I. IN VIVO STUDIES WITH THE VIRUSES OF WESTERN AND EASTERN EQUINE ENCEPHALOMYELITIS, ST. LOUIS ENCEPHALITIS, POLIOMYELITIS (LANSING), AND RABIES. (19871570)
1946
50
BLOOD-SUCKING VECTORS OF ENCEPHALITIS: EXPERIMENTAL TRANSMISSION OF ST. LOUIS ENCEPHALITIS (HUBBARD STRAIN) TO WHITE SWISS MICE BY THE AMERICAN DOG TICK, DERMACENTOR VARIABILIS SAY. (19871380)
1944

Genetic Variations for St. Louis Encephalitis

Expression for genes affiliated with St. Louis Encephalitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with St. Louis Encephalitis

Search GEO for disease gene expression data for St. Louis Encephalitis.

Pathways for genes affiliated with St. Louis Encephalitis

Sources:
30KEGG, 53R&D Systems, 52QIAGEN
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Compounds for genes affiliated with St. Louis Encephalitis

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rottlerin459.5RAF1, CD40LG
2herbimycin a45 6010.5RAF1, CD40LG
3rituximab45 50 1111.4RAF1, CD40LG
4theophylline45 29 11 2412.2RAF1, CD40LG

GO Terms for genes affiliated with St. Louis Encephalitis

Sources:
16Gene Ontology
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Molecular functions related to St. Louis Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2CD40LG, IFNA8

Products for genes affiliated with St. Louis Encephalitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for St. Louis Encephalitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet