MCID: STC004
MIFTS: 39

Stachybotrys Chartarum malady

Rare diseases category

Summaries for Stachybotrys Chartarum

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Wikipedia:63 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards based summary: Stachybotrys Chartarum, also known as stachybotrys atra, is related to allergic asthma and asthma. An important gene associated with Stachybotrys Chartarum is CCL7 (chemokine (C-C motif) ligand 7), and among its related pathways are Hypertrophy Model and Malaria. The compounds anaphylatoxin and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and brain, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Stachybotrys Chartarum

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Stachybotrys Chartarum, Aliases & Descriptions:

Name: Stachybotrys Chartarum 41
 
Stachybotrys Atra 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Stachybotrys Chartarum

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Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1allergic asthma29.9CCL3, CCL7, CCL4, IL18, IL3
2asthma29.1LIF, CCL3, CCL7, CCL4, IL18, IL3
3neuronitis10.5
4hemosiderosis10.5
5malignant histiocytosis10.5CSF1
6myelofibrosis10.5LIF
7muckle-wells syndrome10.4IL1B
8blau syndrome10.4IL1B
9intervertebral disc disease10.4IL1B
10pleurisy10.4IL1B
11sick building syndrome10.3
12rhinitis10.3
13periapical granuloma10.3CCL4, CCL3
14langerhans-cell histiocytosis10.3CSF1, LIF
15dengue disease10.3CCL3, CCL4
16lyme disease10.3CCL3, CCL4
17human immunodeficiency virus infectious disease10.3CCL3, CCL4
18aspergillosis10.3CSF1, CCL3
19pleural tuberculosis10.3CCL3, IL18
20adult-onset still's disease10.2CSF1, IL18
21measles10.2CCL4, CSF1
22plasmodium falciparum malaria10.2CCL4, IL18
23pulmonary sarcoidosis10.2IL18, CCL3
24cinca syndrome10.2IL1B, IL18
25alcoholic hepatitis10.2IL1A, CCL3
26behcet's disease10.2CCL3, IL18
27meningitis10.2IL1B, CCL4
28interstitial lung disease10.2IL1A, CCL3
29bacterial vaginosis10.2IL1B, IL1A
30peritonitis10.2IL1B, CXCL2, LIF
31gingival overgrowth10.1IL1A, IL1B
32arthritis10.1IL1B, IL1A
33gingivitis10.1IL1A, IL1B
34secondary syphilis10.1CCL3, CCL4, CSF1
35lupus nephritis10.1CSF1, IL18
36psoriatic arthritis10.1IL1B, IL1A
37malaria10.1IL1B, IL1A
38gastritis10.1IL1B, CCL3, CXCL2
39stroke, ischemic10.1LIF, CCL3, CCL4
40neutropenia, cyclic10.1IL3, CSF1
41toxic shock syndrome10.1CCL3, CCL4, IL1B
42pulmonary tuberculosis10.1IL18, CCL4, CCL3
43encephalitis10.1IL1B, CCL4, CCL3
44pulmonary alveolar proteinosis10.1IL3, CSF1
45pregnancy loss, recurrent 110.1CSF1, IL18, LIF
46pulmonary fibrosis10.1IL1B, CCL4, CCL3
47systemic scleroderma10.1CCL7, CCL4, IL1A
48monocytic leukemia10.1CSF1, IL1B, LIF
49skin disease10.1IL1A, IL1B
50pancytopenia10.1CSF1, IL3

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Symptoms for Stachybotrys Chartarum

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Drugs & Therapeutics for Stachybotrys Chartarum

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Drug clinical trials:

Search ClinicalTrials for Stachybotrys Chartarum

Search NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

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Anatomical Context for Stachybotrys Chartarum

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MalaCards organs/tissues related to Stachybotrys Chartarum:

31
Lung, Testes, Brain, Colon, Monocytes

Animal Models for Stachybotrys Chartarum or affiliated genes

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MGI Mouse Phenotypes related to Stachybotrys Chartarum:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5CSF1, IL1A, IL1B, IL18, LIF
2MP:00053767.2LIF, CCL3, IL18, IL3, IL1B, IL1A
3MP:00053977.2CSF1, LIF, CCL3, CCL7, IL18, IL3
4MP:00053877.1LIF, CCL3, CCL7, IL18, IL3, IL1B

Publications for Stachybotrys Chartarum

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Articles related to Stachybotrys Chartarum:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. (24387683)
2014
2
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. (24139181)
2013
3
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. (22552393)
2012
4
Allergen of the month--Stachybotrys chartarum. (22626607)
2012
5
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. (21982832)
2011
6
Characterization of human antigenic proteins SchS21 and SchS34 from Stachybotrys chartarum. (21109751)
2011
7
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. (19796210)
2010
8
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. (20150440)
2010
9
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. (20077192)
2009
10
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. (20061240)
2009
11
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. (18007011)
2008
12
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. (17267247)
2007
13
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. (17186382)
2007
14
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). (17764432)
2007
15
Pulmonary cytotoxicity of secondary metabolites of Stachybotrys chartarum (Ehrenb.) Hughes. (17195998)
2006
16
The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity. (16436280)
2006
17
DNA damage, redox changes, and associated stress-inducible signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. (16476459)
2006
18
Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice. (16322647)
2006
19
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. (16754538)
2006
20
Interactions between Streptomyces californicus and Stachybotrys chartarum can induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages. (15667833)
2005
21
Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms. (15647601)
2005
22
Ultraviolet germicidal irradiation disinfection of Stachybotrys chartarum. (16391660)
2005
23
Antibodies against Stachybotrys chartarum extract and its antigenic components, Stachyhemolysin and Stachyrase-A: a new clinical biomarker. (15874884)
2005
24
Comparison of immunomodulator mRNA and protein expression in the lungs of Stachybotrys chartarum spore-exposed mice. (16020192)
2005
25
Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells. (15574675)
2005
26
Attributes of Stachybotrys chartarum and its association with human disease. (14767429)
2004
27
Wall relative humidity: a simple and reliable index for predicting Stachybotrys chartarum infestation in dwellings. (15104787)
2004
28
Protein translation inhibition by Stachybotrys chartarum conidia with and without the mycotoxin containing polysaccharide matrix. (15487326)
2004
29
Immunochemical Assay for Satratoxin G and other Macrocyclic Trichothecenes Associated with Indoor Air Contamination by Stachybotrys chartarum. (20021149)
2003
30
Molecular and phenotypic descriptions of Stachybotrys chlorohalonata sp. nov. and two chemotypes of Stachybotrys chartarum found in water-damaged buildings. (21149024)
2003
31
Effect of plasterboard composition on Stachybotrys chartarum growth and biological activity of spores. (12839740)
2003
32
Cryptic species in Stachybotrys chartarum. (21156555)
2002
33
Isolation and properties of stachyrase A, a chymotrypsin-like serine proteinase from Stachybotrys chartarum. (11748212)
2002
34
IgE-reactive proteins from Stachybotrys chartarum. (12141716)
2002
35
Stachylysin may be a cause of hemorrhaging in humans exposed to Stachybotrys chartarum. (11895972)
2002
36
Preliminary description of antigenic components characteristic of Stachybotrys chartarum. (11237513)
2001
37
Specific detection of Stachybotrys chartarum in pure culture using quantitative polymerase chain reaction. (11352593)
2001
38
Analysis of pulmonary surfactant by Fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) spores. (11245829)
2001
39
Stachybotrys chartarum: current knowledge of its role in disease. (11104457)
2000
40
The time course of responses to intratracheally instilled toxic Stachybotrys chartarum spores in rats. (11227851)
2000
41
Reduction of pulmonary toxicity of Stachybotrys chartarum spores by methanol extraction of mycotoxins. (10877773)
2000
42
Atranones A-G, from the toxigenic mold Stachybotrys chartarum. (11130678)
2000
43
Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: quantitative assessment before, during, and after remediation. (10741843)
2000
44
Quantification of siderophore and hemolysin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis. (10831457)
2000
45
Volatile sesquiterpenes from Stachybotrys chartarum: Indicators for trichothecene producing mold species? (19009424)
2000
46
Sanitation of wallboard colonized with Stachybotrys chartarum. (10387112)
1999
47
Respiratory effects in mice exposed to airborne emissions from Stachybotrys chartarum and implications for risk assessment. (9783329)
1998
48
Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment. (8738349)
1996
49
Some cultural conditions that control production of verrucarin J, a cytotoxic metabolite of Stachybotrys chartarum. (7202311)
1982
50
Discovery of toxicogenic Stachybotrys chartarum strains in Finland. (5013039)
1972

Variations for Stachybotrys Chartarum

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Expression for genes affiliated with Stachybotrys Chartarum

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Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

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Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL1A, IL18
29.6IL1B, IL18
3
Show member pathways
IL27-mediated signaling events36
9.6IL1B, IL18
49.6IL18, IL1B
59.6IL18, IL1B
69.5IL1B, IL1A
7
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.5IL1A, IL1B
89.5IL1A, IL1B
99.5IL1A, IL1B
109.2IL18, IL1B, CSF1
119.2CSF1, IL1A, IL1B
12
Show member pathways
9.2IL1A, IL1B, IL18
13
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.2IL1A, IL1B, IL18
14
Show member pathways
9.2IL18, IL1B, IL1A
159.2IL18, IL1B, IL1A
16
Show member pathways
9.1CCL3, CCL4
17
Show member pathways
9.1IL1A, IL1B, IL3
18
Show member pathways
9.1IL1A, IL1B, IL3
199.1CSF1, IL1B, CCL3
209.0IL1B, IL18, CXCL2
21
Show member pathways
9.0CXCL2, IL18, IL1B
228.9IL1A, IL1B, CXCL2
23
Show member pathways
8.8CCL4, IL18, IL1B
248.7IL3, IL1B, IL1A, CSF1
25
Show member pathways
8.7IL1A, IL1B, IL3, IL18
26
Show member pathways
8.7IL18, IL3, IL1B, IL1A
278.7IL18, IL3, IL1B, IL1A
28
Show member pathways
8.7IL18, IL3, IL1B, IL1A
298.7LIF, CXCL2, IL1B, CSF1
30
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6IL1B, CCL4, CCL3
318.6CSF1, IL1A, IL1B, CXCL2
328.6CCL3, IL3, IL1B, IL1A
338.5CXCL2, CCL4, IL1B
348.3CCL3, IL18, IL1B, IL1A, CSF1
35
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.2CCL3, CCL4, IL18, IL1B
36
Show member pathways
8.2CCL4, CCL7, CCL3, CXCL2
37
Show member pathways
8.2CXCL2, CCL3, CCL7, CCL4
38
Show member pathways
8.2CXCL2, CCL3, CCL7, CCL4
39
Show member pathways
8.2CXCL2, CCL3, CCL7, CCL4
40
Show member pathways
7.2CXCL2, CCL3, CCL4, IL18, IL1B, IL1A
41
Show member pathways
7.1CCL3, CCL7, CCL4, IL18, IL3, IL1B
42
Show member pathways
5.8CCL7, CCL3, CXCL2, LIF, CCL4, IL18
43
Show member pathways
5.8CSF1, IL1A, IL1B, IL3, IL18, CCL4
44
Show member pathways
5.8LIF, CSF1, IL1A, IL1B, IL3, IL18
45
Show member pathways
5.8LIF, CXCL2, CCL3, CCL7, CCL4, IL18

Compounds for genes affiliated with Stachybotrys Chartarum

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Compounds related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1anaphylatoxin439.0CCL3, CCL7, IL1B, IL3
2poly(i-c)438.8CCL3, IL1B, IL3, IL18
3methylcellulose438.8LIF, CCL3, IL3, IL1A, CSF1
4larc438.8IL1A, CCL4, CCL7, CCL3
5polyinosinic-polycytidylic acid438.7IL18, CSF1, IL1A, CCL3, IL1B
6tgf beta1438.7IL18, LIF, IL1B, CCL3, CSF1
7pdtc438.6IL1A, IL18, CCL3, IL1B
85fluorouracil438.6LIF, CSF1, CCL3, IL18, IL3
9calcitriol43 59 24 1211.6IL1A, CSF1, LIF, IL1B, IL3
10hydrocortisone43 2 59 1211.6LIF, CCL3, IL3, IL1B, IL1A
11mip 1alpha438.5CCL4, IL3, IL1B, CCL3
12ribonucleic acid438.5CCL3, IL1A, CCL7, IL1B, LIF
13genistein43 28 59 2 24 1213.4CSF1, IL1B, IL3, LIF, CCL7, IL1A
14leukotriene b443 59 2410.3CCL7, CSF1, IL1A, IL1B, CCL3, IL3
15ccl443 289.3CCL7, CXCL2, CCL4, CCL3
16ivig438.3IL3, CCL4, IL1B, IL1A, CSF1
17neopterin438.3IL1A, CSF1, IL3, CCL3, IL18, IL1B
18lactate438.1CSF1, IL3, IL18, CCL3, CXCL2, LIF
19n acetylcysteine438.1IL1B, IL18, IL3, CXCL2, CSF1
20testosterone43 59 24 1211.0CCL3, IL1A, CSF1, IL3, LIF, IL18
21fmlp438.0CSF1, CCL3, CCL7, IL3, IL1B, IL1A
2212-o-tetradecanoylphorbol 13-acetate438.0CSF1, IL3, CXCL2, IL1A, LIF
23actinomycin d438.0CCL3, LIF, CCL7, IL3, IL1B, IL1A
24creatinine438.0LIF, CCL4, IL18, CSF1, IL1A, IL3
25ly294002438.0CXCL2, CCL3, CSF1, IL1B, IL3, IL18
26gm-csf43 289.0IL1A, IL1B, IL3, IL18, CCL3, LIF
27ionomycin437.9CCL3, IL18, CCL4, IL1A, CSF1, IL3
28thymidine43 248.9IL1B, CSF1, CCL3, IL1A, LIF, IL18
29tarc437.9CXCL2, IL1A, CCL3, IL18, CCL4, CCL7
30cyclosporin a43 28 599.8IL3, LIF, IL18, CCL3, CCL4, IL1A
31indomethacin43 28 59 1210.8IL1B, IL18, CCL4, CSF1, CCL3, IL1A
32prostaglandin437.8CXCL2, CCL4, IL1B, IL1A, LIF, CSF1
33heparin43 28 24 1210.8CCL4, LIF, CCL3, CSF1, IL3, IL1A
34h2o2437.8LIF, IL18, CSF1, IL1A, IL3, CCL3
35wortmannin437.7CXCL2, CSF1, IL3, CCL4, CCL3, LIF
36histamine43 28 249.5IL18, CSF1, CCL4, CCL7, IL3, CCL3
37ccl343 288.3IL1A, CCL3, IL1B, CXCL2, IL18, CCL7
38groalpha437.3IL1A, IL1B, IL18, CCL4, CCL7, CCL3
39endotoxin437.3IL1A, IL18, CCL4, IL1B, CCL3, CXCL2
40sb 20358043 598.3CXCL2, IL18, CCL4, CCL3, IL1B, IL1A
41nitric oxide43 24 129.2IL1A, CCL4, LIF, CXCL2, IL18, CCL3
42il 10437.2CSF1, IL1A, IL1B, IL3, CCL4, CCL3
43retinoic acid43 248.1IL3, CCL3, CSF1, IL1A, IL1B, IL18
44pge2437.0LIF, CXCL2, CCL3, CCL4, IL18, IL1B
45vegf436.9IL1B, LIF, CXCL2, CCL3, CCL4, IL1A
46pd 98,059436.9LIF, CSF1, IL1B, IL3, CCL4, CCL3
47cycloheximide436.8LIF, CCL3, IL1B, CSF1, CCL7, IL1A
48serine436.7CSF1, IL1A, IL3, LIF, CCL4, CCL7
49rantes436.2LIF, CXCL2, CCL3, CCL7, CCL4, IL18
50dexamethasone43 49 28 129.2CCL4, IL18, IL3, IL1A, CSF1, CCL7

GO Terms for genes affiliated with Stachybotrys Chartarum

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Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.4CCL3, CCL7, CCL4, IL18, IL3, IL1B
2extracellular spaceGO:00056155.5CSF1, LIF, CXCL2, CCL3, CCL7, CCL4

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage differentiationGO:004565110.2LIF, CSF1
2eosinophil chemotaxisGO:004824510.0CCL3, CCL7
3monocyte chemotaxisGO:000254810.0CCL3, CCL7
4positive regulation of granulocyte macrophage colony-stimulating factor productionGO:00327259.9IL1B, IL18
5fever generationGO:00016609.9IL1A, IL1B
6ectopic germ cell programmed cell deathGO:00352349.9IL1A, IL1B
7positive regulation of NF-kappaB import into nucleusGO:00423469.9IL1B, IL18
8positive regulation of interleukin-2 biosynthetic processGO:00450869.9IL1B, IL1A
9positive regulation vascular endothelial growth factor productionGO:00105759.8IL1B, IL1A
10embryo implantationGO:00075669.8LIF, IL1B
11positive regulation of mitosisGO:00458409.8IL1B, IL1A
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.7IL1A, IL1B
13positive regulation of interferon-gamma productionGO:00327299.7IL1B, IL18
14extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7IL1A, IL1B
15protein kinase B signalingGO:00434919.7IL1B, CCL3
16positive regulation of cell migrationGO:00303359.6CSF1, CCL7, CCL3
17positive regulation of gene expressionGO:00106289.5CSF1, IL18, CCL3
18neutrophil chemotaxisGO:00305939.5CCL3, IL1B
19negative regulation by host of viral transcriptionGO:00439229.5CCL4, CCL3
20positive regulation of cell divisionGO:00517819.4IL1B, IL1A
21lipopolysaccharide-mediated signaling pathwayGO:00316639.4IL1B, IL18, CCL3
22cellular response to organic cyclic compoundGO:00714079.4CCL3, IL18, IL1B
23MAPK cascadeGO:00001659.4CCL3, IL18, IL1B
24positive regulation of calcium-mediated signalingGO:00508509.4CCL4, CCL3
25positive regulation of calcium ion transportGO:00519289.4CCL4, CCL3
26chemotaxisGO:00069359.4CCL7, CCL3, CXCL2
27positive regulation of inflammatory responseGO:00507299.3CCL3, IL18
28negative regulation of cell proliferationGO:00082859.2IL1A, IL1B, LIF
29positive regulation of natural killer cell chemotaxisGO:020005039.2CCL3, CCL7, CCL4
30cell chemotaxisGO:00603269.0CCL4, CXCL2
31cell-cell signalingGO:00072677.9CCL3, CCL7, CCL4, IL18, IL3, IL1B
32immune responseGO:00069557.0LIF, CXCL2, CCL7, CCL4, IL18, IL3
33inflammatory responseGO:00069547.0CSF1, CXCL2, CCL3, CCL7, CCL4, IL18

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.4CSF1, IL3, LIF
2interleukin-1 receptor bindingGO:00051499.2IL1A, IL1B
3CCR5 chemokine receptor bindingGO:00317309.0CCL3, CCL4
4CCR1 chemokine receptor bindingGO:00317268.8CCL4, CCL7, CCL3
5chemokine activityGO:00080098.3CXCL2, CCL3, CCL7, CCL4
6cytokine activityGO:00051257.3CSF1, IL1A, IL1B, IL3, IL18, CCL4

Products for genes affiliated with Stachybotrys Chartarum

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3CDC
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22GTR
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25ICD10
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27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
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