MCID: STC004
MIFTS: 37

Stachybotrys Chartarum malady

Category: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

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Aliases & Descriptions for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 48
 
Stachybotrys Atra 48

Classifications:



Summaries for Stachybotrys Chartarum

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Wikipedia:71 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards based summary: Stachybotrys Chartarum, also known as stachybotrys atra, is related to asthma and panner disease. An important gene associated with Stachybotrys Chartarum is IL18 (Interleukin 18), and among its related pathways are Hypertrophy Model and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are cardiovascular system and integument.

Related Diseases for Stachybotrys Chartarum

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Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1asthma28.0CCL3, CCL5, IL18, IL1A, IL1B, IL3
2panner disease10.5IL6, TNF
3aortic arch interruption10.4IL6, TNF
4anterior dislocation of lens10.4CSF1, IL6
5cutaneous leishmaniasis10.4IL6, TNF
6corneal deposit10.4IL1B, IL6
7maligant granulosa cell tumor of ovary10.4IL6, TNF
8tricho odonto onycho dermal syndrome10.4IL6, TNF
9tarsal tunnel syndrome10.4IL1B, IL6
10scrotum melanoma10.4CCL2, IL18, IL6
11diabetic cataract10.4IL1A, IL1B
12silo filler's disease10.4IL18, IL1B
13small intestine lymphoma10.4IL1A, TNF
14renal cell carcinoma 410.3IL18, IL6, TNF
15hemometra10.3IL6, LIF, TNF
16vertebral artery insufficiency10.3IL18, IL6, TNF
17leukoplakia10.3IL18, IL6, TNF
18neurogenic bowel10.3IL18, IL6, TNF
19vibrio vulnificus infection10.3CCL2, IL6
20vestibular nystagmus10.3IL18, IL6, TNF
21midline interhemispheric variant of holoprosencephaly10.3IL18, IL1B, IL6
22thyroid malformation10.3IL1B, TNF
23syphilitic encephalitis10.3IL18, IL1B, IL6
24epstein-barr virus hepatitis10.3IL1A, IL6, TNF
25abdominal chemodectomas with cutaneous angiolipomas10.3IL6, TNF
26benign mammary dysplasia10.3CCL2, CCL5, IL6
27primary biliary cirrhosis10.3IL1A, IL6, TNF
28hemoglobinopathy10.3IL1B, IL6
29hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.3IL1B, TNF
30mental retardation anophthalmia craniosynostosis10.3IL1A, IL1B
31melorheostosis10.2IL1B, IL6
32exophthalmos10.2CCL7, IL3, TNF
33hyperparathyroidism10.2CCL2, IL1B
34periodic paralyses10.2IL1A, IL1B, IL6
35antigen-peptide-transporter 2 deficiency10.2CCL2, IL6, TNF
36baetz-greenwalt syndrome10.2IL1B, TNF
37gastric ulcer10.2CCL5, IL6, TNF
38pulmonary hypertension10.2IL1B, TNF
39intervertebral disc disease10.2IL1A, IL1B, IL6
40geniculate herpes zoster10.2CCL5, IL6, TNF
41alopecia10.2CCL2, IL6, TNF
42renal tubular acidosis10.2CCL2, IL18, TNF
43hemosiderosis10.2
44neuronitis10.2
45kernicterus10.2CCL2, IL6, TNF
46isthmus cancer10.2IL1A, IL6, TNF
47short bowel syndrome10.1CCL2, IL6, TNF
48mixed lacrimal gland cancer10.1CCL2, IL6, TNF
49histoplasmosis pericarditis10.1CCL2, IL6, TNF
50infancy electroclinical syndrome10.1IL1B, IL6

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Symptoms & Phenotypes for Stachybotrys Chartarum

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MGI Mouse Phenotypes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CSF1, CXCL2, IL18, IL1A, IL1B, IL6
2MP:00107718.1CSF1, IL18, IL1A, IL1B, IL6, LIF
3MP:00053878.0CCL2, CCL5, CSF1, IL18, IL1A, IL1B

Drugs & Therapeutics for Stachybotrys Chartarum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

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Anatomical Context for Stachybotrys Chartarum

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MalaCards organs/tissues related to Stachybotrys Chartarum:

36
Lung, Testes, Monocytes, Brain, Colon

Publications for Stachybotrys Chartarum

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Articles related to Stachybotrys Chartarum:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. (27148627)
2016
2
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. (27997578)
2016
3
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. (27476483)
2016
4
Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. (27097835)
2016
5
Genome Sequence of Stachybotrys chartarum Strain 51-11. (26430036)
2015
6
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. (26036596)
2015
7
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. (24387683)
2014
8
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. (25346283)
2014
9
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. (23180821)
2013
10
Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus Stachybotrys chartarum MXH-X73. (24308675)
2013
11
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. (24139181)
2013
12
Microbial volatile organic compound emissions from Stachybotrys chartarum growing on gypsum wallboard and ceiling tile. (24308451)
2013
13
Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. (21384497)
2013
14
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. (22552393)
2012
15
Allergen of the month--Stachybotrys chartarum. (22626607)
2012
16
Recurrence of Stachybotrys chartarum during mycological and toxicological study of bioaerosols collected in a dairy cattle shed. (22462447)
2012
17
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. (21505872)
2011
18
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. (21982832)
2011
19
Characterization of human antigenic proteins SchS21 and SchS34 from Stachybotrys chartarum. (21109751)
2011
20
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. (21505873)
2011
21
The influence of water activity and temperature on germination, growth and sporulation of Stachybotrys chartarum strains. (21347692)
2011
22
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. (20150440)
2010
23
Pulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicity. (20385656)
2010
24
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. (19796210)
2010
25
The relative allergenicity of Stachybotrys chartarum compared to house dust mite extracts in a mouse model. (20235799)
2010
26
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. (20077192)
2009
27
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. (19459771)
2009
28
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. (20061240)
2009
29
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. (18041646)
2008
30
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. (18460072)
2008
31
Immunohistochemical and immunocytochemical detection of SchS34 antigen in Stachybotrys chartarum spores and spore impacted mouse lungs. (18046622)
2008
32
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. (18007011)
2008
33
Characterization of monoclonal antibodies to an antigenic protein from Stachybotrys chartarum and its measurement in house dust. (18242638)
2008
34
Detection of Stachybotrys chartarum using rRNA, tri5, and beta-tubulin primers and determining their relative copy number by real-time PCR. (18499423)
2008
35
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. (17267247)
2007
36
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. (17420079)
2007
37
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. (17186382)
2007
38
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). (17764432)
2007
39
Comparison of four different methods for extraction of Stachybotrys chartarum spore DNA and verification by real-time PCR. (17499865)
2007
40
An in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells. (17411351)
2007
41
DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins. (17534970)
2007
42
The role of fungal proteinases in pathophysiology of Stachybotrys chartarum. (17610048)
2007
43
Testing antimicrobial cleaner efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. (18062486)
2007
44
Pulmonary cytotoxicity of secondary metabolites of Stachybotrys chartarum (Ehrenb.) Hughes. (17195998)
2006
45
The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity. (16436280)
2006
46
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. (16754538)
2006
47
Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. (16882529)
2006
48
Co-cultivation of Streptomyces californicus and Stachybotrys chartarum stimulates the production of cytostatic compound(s) with immunotoxic properties. (17095029)
2006
49
Solvent comparison in the isolation, solubilization, and toxicity of Stachybotrys chartarum spore trichothecene mycotoxins in an established in vitro luminescence protein translation inhibition assay. (16497399)
2006
50
DNA damage, redox changes, and associated stress-inducible signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. (16476459)
2006

Variations for Stachybotrys Chartarum

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Expression for genes affiliated with Stachybotrys Chartarum

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Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

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Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL18, IL1A
29.7IL1B, IL6
39.7IL3, IL6, LIF
49.5CCL2, IL6, LIF
59.5IL6, LIF, TNF
69.4IL18, IL1A, IL1B
79.3IL18, IL1B, TNF
89.2IL1B, IL6, TNF
99.1CSF1, IL3, IL6, TNF
109.0CCL5, IL1A, IL1B, IL6
11
Show member pathways
9.0IL18, IL1B, IL6, TNF
129.0IL18, IL1B, IL6, TNF
138.9IL1A, IL1B, IL6, TNF
148.9IL1A, IL1B, IL6, TNF
15
Show member pathways
8.9IL1A, IL1B, IL6, TNF
16
Show member pathways
8.9IL1A, IL1B, IL6, TNF
178.9IL1A, IL1B, IL6, TNF
188.9IL1A, IL1B, IL6, TNF
198.9CSF1, IL1B, IL6, TNF
208.8CSF1, IL1A, IL1B, TNF
218.7CCL3, IL18, IL1B, TNF
22
Show member pathways
8.7IL18, IL1A, IL1B, IL6, TNF
238.7IL18, IL1A, IL1B, IL6, TNF
24
Show member pathways
8.7CCL3, CCL4, TNF
25
Show member pathways
8.6IL1A, IL1B, IL3, IL6, TNF
26
Show member pathways
8.6CCL2, IL18, IL1B, IL6, TNF
278.6CCL2, IL18, IL1B, IL6, TNF
288.6CCL3, IL1A, IL1B, IL3, IL6
298.5CCL2, IL1A, IL1B, IL6, TNF
308.5CCL2, CSF1, IL18, IL1B, TNF
318.4CCL2, CCL5, IL1B, IL3, TNF
32
Show member pathways
8.4IL18, IL1A, IL1B, IL3, IL6, TNF
33
Show member pathways
8.4IL18, IL1A, IL1B, IL3, IL6, TNF
348.4CXCL2, IL18, IL1B, IL6, TNF
35
Show member pathways
8.4CCL3, CCL4, IL18, IL1B
368.3CSF1, IL1A, IL1B, IL3, IL6, TNF
37
Show member pathways
8.3CCL4, CCL5, IL18, IL1B, IL6
388.2CCL2, CCL3, CSF1, IL1B, TNF
398.1CCL4, CXCL2, IL1B, TNF
408.0CSF1, CXCL2, IL1A, IL1B, IL6, TNF
41
Show member pathways
7.9CCL2, CCL5, IL18, IL1A, IL1B, IL6
427.9CCL2, CXCL2, IL1A, IL1B, IL6, TNF
43
Show member pathways
7.6CCL2, CCL5, CXCL2, IL18, IL1B, IL6
44
Show member pathways
7.4CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
457.2CCL2, CCL5, CSF1, CXCL2, IL1B, IL6
46
Show member pathways
7.2CCL3, CCL4, CXCL2, IL18, IL1A, IL1B
47
Show member pathways
7.1CCL2, CCL3, CCL4, CCL5, IL1B, IL6
487.0CCL2, CCL3, CCL5, CSF1, IL18, IL1A
49
Show member pathways
6.4CCL2, CCL3, CCL4, CCL5, CCL7, IL18
50
Show member pathways
6.0CCL2, CCL3, CCL4, CCL5, CCL7, IL18

GO Terms for genes affiliated with Stachybotrys Chartarum

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Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055765.8CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
2extracellular spaceGO:00056154.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hormone secretionGO:004688810.7IL6, LIF
2cellular response to ethanolGO:007136110.6CCL5, CCL7
3positive regulation of macrophage differentiationGO:004565110.6CSF1, LIF
4epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
5negative regulation of lipid storageGO:001088810.5IL6, TNF
6positive regulation of chemokine productionGO:003272210.5IL6, TNF
7regulation of vascular endothelial growth factor productionGO:001057410.5CCL2, IL6
8positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.5IL18, IL1B
9positive regulation of astrocyte differentiationGO:004871110.5IL1B, LIF
10ectopic germ cell programmed cell deathGO:003523410.4IL1A, IL1B
11fever generationGO:000166010.4IL1A, IL1B
12positive regulation of monocyte chemotaxisGO:009002610.4CCL2, CCL5
13positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.4IL18, IL6, LIF
14positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.4IL3, IL6, LIF
15positive regulation of interleukin-2 biosynthetic processGO:004508610.4IL1A, IL1B
16positive regulation of monocyte chemotactic protein-1 productionGO:007163910.4IL1A, IL1B
17astrocyte cell migrationGO:004361510.4CCL2, CCL3
18positive regulation of calcium ion importGO:009028010.3CCL2, CCL3
19chronic inflammatory response to antigenic stimulusGO:000243910.3IL1B, TNF
20negative regulation of lipid catabolic processGO:005099510.3IL1B, TNF
21positive regulation of calcidiol 1-monooxygenase activityGO:006055910.3IL1B, TNF
22positive regulation of chemokine biosynthetic processGO:004508010.3IL1B, TNF
23response to cholesterolGO:007072310.2CCL3, CCL5
24response to salt stressGO:000965110.2CCL5, TNF
25positive regulation of heterotypic cell-cell adhesionGO:003411610.2IL1B, TNF
26positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IL1B, TNF
27positive regulation of peptidyl-serine phosphorylationGO:003313810.2IL6, LIF, TNF
28regulation of establishment of endothelial barrierGO:190314010.2IL1B, TNF
29regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.2IL1B, TNF
30cellular response to lipopolysaccharideGO:007122210.2CCL2, IL6, TNF
31humoral immune responseGO:000695910.1CCL2, IL6, TNF
32positive regulation of smooth muscle cell proliferationGO:004866110.1CCL5, IL6, TNF
33eosinophil chemotaxisGO:004824510.1CCL3, CCL5, CCL7
34positive regulation of macrophage chemotaxisGO:001075910.1CCL2, CCL5, CSF1
35positive regulation of angiogenesisGO:004576610.0CCL5, IL1A, IL1B
36positive regulation of osteoclast differentiationGO:004567210.0CCL5, CSF1, TNF
37positive regulation of T cell proliferationGO:004210210.0CCL5, IL1B, IL6
38positive regulation of cell adhesionGO:004578510.0CCL2, CCL5, TNF
39positive regulation of interferon-gamma productionGO:003272910.0IL18, IL1B, TNF
40positive regulation of NF-kappaB import into nucleusGO:004234610.0IL18, IL1B, TNF
41positive regulation of nitric oxide biosynthetic processGO:004542910.0IL1B, IL6, TNF
42positive regulation of protein kinase B signalingGO:00518979.9CCL3, IL6, TNF
43negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.9IL1A, IL1B, TNF
44lymphocyte chemotaxisGO:00482479.9CCL2, CCL3, CCL5
45macrophage chemotaxisGO:00482469.9CCL2, CCL3, CCL5
46positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9IL1B, IL6, TNF
47response to heatGO:00094089.9CCL2, IL1B, IL6
48response to gamma radiationGO:00103329.9CCL2, CCL7, IL1B
49positive regulation of JNK cascadeGO:00463309.9IL1A, IL1B, TNF
50positive regulation of calcium-mediated signalingGO:00508509.9CCL3, CCL4

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:003172710.4CCL2, CCL7
2interleukin-1 receptor bindingGO:00051499.8IL1A, IL1B
3growth factor activityGO:00080839.7CSF1, IL3, IL6, LIF
4phospholipase activator activityGO:00160049.6CCL3, CCL5
5CCR5 chemokine receptor bindingGO:00317309.4CCL3, CCL4, CCL5
6CCR1 chemokine receptor bindingGO:00317269.1CCL3, CCL4, CCL5, CCL7
7chemokine activityGO:00080098.1CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
8cytokine activityGO:00051257.1CCL2, CCL4, CSF1, IL18, IL1A, IL1B

Sources for Stachybotrys Chartarum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet