MCID: STC004
MIFTS: 40

Stachybotrys Chartarum

Categories: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

MalaCards integrated aliases for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 49
Stachybotrys Atra 49

Classifications:



Summaries for Stachybotrys Chartarum

MalaCards based summary : Stachybotrys Chartarum, also known as stachybotrys atra, is related to asthma and b-cell growth factor. An important gene associated with Stachybotrys Chartarum is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, testes and monocytes, and related phenotypes are cardiovascular system and immune system

Wikipedia : 72 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

Related Diseases for Stachybotrys Chartarum

Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 asthma 27.9 CCL2 CCL3 CCL5 IL18 IL1A IL1B
2 b-cell growth factor 10.5 IL3 IL6
3 obesity-hypoventilation syndrome 10.4 CCL5 IL6
4 leukoregulin 10.4 CSF1 IL1A
5 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
6 critical limb ischemia 10.4 IL6 TNF
7 streptococcal toxic-shock syndrome 10.3 IL6 TNF
8 recurrent corneal erosion 10.3 IL1B IL6
9 bagassosis 10.3 IL1B IL6
10 denture stomatitis 10.3 CCL2 IL6
11 periodontitis, chronic 10.3 IL1B IL6
12 acute cystitis 10.3 CCL2 IL18 IL6
13 chronic follicular conjunctivitis 10.3 IL1A IL1B
14 retinitis pigmentosa 55 10.3 IL6 TNF
15 skin conditions 10.3 IL1A TNF
16 leukomalacia 10.3 IL18 IL6 TNF
17 null-cell leukemia 10.3 IL6 LIF TNF
18 fasciitis 10.3 IL18 IL6 TNF
19 hemosiderosis 10.3
20 neuronitis 10.3
21 allergic hypersensitivity disease 10.3
22 rasmussen encephalitis 10.3 IL18 IL6 TNF
23 paracoccidioidomycosis 10.3 IL18 IL6 TNF
24 melioidosis 10.3 IL18 IL6 TNF
25 brucellosis 10.3 IL18 IL6 TNF
26 uremic pruritus 10.2 IL18 IL1B IL6
27 schnitzler syndrome 10.2 IL18 IL1B
28 cysticercosis 10.2 IL18 IL1B IL6
29 polyposis, gastric 10.2 IL1B TNF
30 post-transplant lymphoproliferative disease 10.2 IL1A IL6 TNF
31 purulent labyrinthitis 10.2 CCL2 IL1B
32 scorpion envenomation 10.2 CCL5 IL6 TNF
33 viral meningitis 10.2 CCL2 CCL5 IL6
34 respiratory syncytial virus infectious disease 10.2 CCL3 CCL5
35 anthracosis 10.2 CCL2 TNF
36 glossitis 10.2 IL6 TNF
37 funisitis 10.2 IL1B IL6
38 temporal arteritis 10.2 CCL2 CCL5 IL6
39 staphylococcal toxic shock syndrome 10.2 IL1B TNF
40 pleural tuberculosis 10.2 CCL2 IL18 TNF
41 kashin-beck disease 10.1 IL1B TNF
42 filariasis 10.1 CCL5 IL6 TNF
43 ischemic heart disease 10.1 CCL2 IL6 TNF
44 intervertebral disc disease 10.1 IL1A IL1B IL6
45 vulvar vestibulitis syndrome 10.1 IL1B TNF
46 euthyroid sick syndrome 10.1 IL1B IL6
47 alcoholic hepatitis 10.1 CCL2 IL6 TNF
48 sick building syndrome 10.1
49 rhinitis 10.1
50 allergic asthma 10.1

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to Stachybotrys Chartarum

Symptoms & Phenotypes for Stachybotrys Chartarum

MGI Mouse Phenotypes related to Stachybotrys Chartarum:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 IL1A IL1B IL6 LIF TNF CSF1
2 immune system MP:0005387 9.61 IL1A IL1B IL6 LIF TNF CCL2
3 integument MP:0010771 9.17 IL1A IL1B IL6 LIF TNF CSF1

Drugs & Therapeutics for Stachybotrys Chartarum

Search Clinical Trials , NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

Anatomical Context for Stachybotrys Chartarum

MalaCards organs/tissues related to Stachybotrys Chartarum:

38
Lung, Testes, Monocytes, Brain, Colon

Publications for Stachybotrys Chartarum

Articles related to Stachybotrys Chartarum:

(show top 50) (show all 133)
# Title Authors Year
1
A new phenylspirodrimane dimer from the fungus Stachybotrys chartarum. ( 29288026 )
2018
2
A novel phenylspirodrimane dimer from cultures of the fungus Stachybotrys chartarum. ( 29252003 )
2017
3
Bistachybotrysins A-C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum. ( 29279273 )
2017
4
Stachybotrysins A-G, Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum. ( 28530828 )
2017
5
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. ( 27997578 )
2016
6
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. ( 27148627 )
2016
7
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. ( 27476483 )
2016
8
Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. ( 27097835 )
2016
9
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. ( 26036596 )
2015
10
Genome Sequence of Stachybotrys chartarum Strain 51-11. ( 26430036 )
2015
11
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. ( 25346283 )
2014
12
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. ( 24387683 )
2014
13
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. ( 23180821 )
2013
14
Microbial volatile organic compound emissions from Stachybotrys chartarum growing on gypsum wallboard and ceiling tile. ( 24308451 )
2013
15
Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus Stachybotrys chartarum MXH-X73. ( 24308675 )
2013
16
Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. ( 21384497 )
2013
17
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. ( 24139181 )
2013
18
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. ( 22552393 )
2012
19
Recurrence of Stachybotrys chartarum during mycological and toxicological study of bioaerosols collected in a dairy cattle shed. ( 22462447 )
2012
20
Allergen of the month--Stachybotrys chartarum. ( 22626607 )
2012
21
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. ( 21505872 )
2011
22
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. ( 21505873 )
2011
23
The influence of water activity and temperature on germination, growth and sporulation of Stachybotrys chartarum strains. ( 21347692 )
2011
24
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. ( 21982832 )
2011
25
Characterization of human antigenic proteins SchS21 and SchS34 from Stachybotrys chartarum. ( 21109751 )
2011
26
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. ( 19796210 )
2010
27
Pulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicity. ( 20385656 )
2010
28
The relative allergenicity of Stachybotrys chartarum compared to house dust mite extracts in a mouse model. ( 20235799 )
2010
29
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. ( 20150440 )
2010
30
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. ( 20077192 )
2009
31
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. ( 19459771 )
2009
32
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. ( 20061240 )
2009
33
Detection of Stachybotrys chartarum using rRNA, tri5, and beta-tubulin primers and determining their relative copy number by real-time PCR. ( 18499423 )
2008
34
Immunohistochemical and immunocytochemical detection of SchS34 antigen in Stachybotrys chartarum spores and spore impacted mouse lungs. ( 18046622 )
2008
35
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. ( 18460072 )
2008
36
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18041646 )
2008
37
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. ( 18007011 )
2008
38
Characterization of monoclonal antibodies to an antigenic protein from Stachybotrys chartarum and its measurement in house dust. ( 18242638 )
2008
39
An in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells. ( 17411351 )
2007
40
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. ( 17420079 )
2007
41
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). ( 17764432 )
2007
42
Testing antimicrobial cleaner efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18062486 )
2007
43
DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins. ( 17534970 )
2007
44
The role of fungal proteinases in pathophysiology of Stachybotrys chartarum. ( 17610048 )
2007
45
Comparison of four different methods for extraction of Stachybotrys chartarum spore DNA and verification by real-time PCR. ( 17499865 )
2007
46
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. ( 17267247 )
2007
47
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. ( 17186382 )
2007
48
Solvent comparison in the isolation, solubilization, and toxicity of Stachybotrys chartarum spore trichothecene mycotoxins in an established in vitro luminescence protein translation inhibition assay. ( 16497399 )
2006
49
Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice. ( 16322647 )
2006
50
Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. ( 16882529 )
2006

Variations for Stachybotrys Chartarum

Expression for Stachybotrys Chartarum

Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for Stachybotrys Chartarum

Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
2
Show member pathways
13.82 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
3
Show member pathways
13.68 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
4
Show member pathways
13.59 CCL2 CCL3 CCL4 CCL5 CCL7 IL18
5
Show member pathways
13.42 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
6
Show member pathways
13.38 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
7
Show member pathways
13.23 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
8
Show member pathways
13.06 CCL2 CCL5 CXCL2 IL18 IL1A IL1B
9
Show member pathways
12.94 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
10
Show member pathways
12.91 CCL2 CCL5 IL18 IL1A IL1B IL6
11
Show member pathways
12.87 IL1A IL1B IL3 IL6 TNF
12
Show member pathways
12.8 CCL4 CCL5 IL18 IL1B IL6 TNF
13
Show member pathways
12.75 IL1A IL1B IL3 IL6 TNF
14
Show member pathways
12.66 IL18 IL1A IL1B IL6 TNF
15
Show member pathways
12.66 CCL2 CCL3 CCL4 CCL5 IL1B IL6
16
Show member pathways
12.65 CCL2 IL18 IL1B IL6 TNF
17 12.63 CCL2 CCL5 IL1B IL3 TNF
18
Show member pathways
12.46 CCL2 CCL5 CSF1 IL1B IL6 TNF
19
Show member pathways
12.45 IL1A IL1B IL6 TNF
20
Show member pathways
12.45 CCL2 CCL7 CXCL2 IL1B IL6 TNF
21
Show member pathways
12.33 IL1A IL1B IL6 TNF
22 12.33 IL18 IL1A IL1B IL6 TNF
23
Show member pathways
12.29 IL18 IL1A IL1B IL3 IL6 TNF
24
Show member pathways
12.28 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
25 12.24 IL1A IL1B IL6 TNF
26 12.17 CCL2 IL1A IL1B TNF
27 12.14 CCL2 IL18 IL1A IL1B IL6 LIF
28 12.13 CCL2 CXCL2 IL1A IL1B IL6 TNF
29 12.12 CSF1 IL1A IL1B TNF
30
Show member pathways
12.11 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
31 12.11 CCL2 CCL5 CSF1 CXCL2 IL1B IL6
32 12.08 CSF1 IL3 IL6 TNF
33 12.08 CCL3 IL1A IL1B IL3 IL6
34
Show member pathways
12.06 CCL3 CCL4 IL18 IL1B
35 12.04 IL3 IL6 LIF
36 12.04 IL6 LIF TNF
37 12.04 CCL2 IL1A IL1B IL6 TNF
38
Show member pathways
12.02 IL18 IL1B IL6 TNF
39 12.02 CSF1 IL1A IL1B IL3 IL6 TNF
40 12 CCL3 CCL4 CXCL2 IL18 IL1A IL1B
41 11.98 CCL4 CXCL2 IL1B TNF
42 11.9 IL1B IL6 TNF
43 11.9 CCL3 IL18 IL1B TNF
44 11.87 IL1A IL1B IL6 TNF
45 11.85 CSF1 IL1B IL6 TNF
46
Show member pathways
11.83 CXCL2 IL1A IL1B IL6 TNF
47 11.76 CXCL2 IL18 IL1B IL6 TNF
48 11.76 CCL2 CCL3 CCL5 CSF1 IL18 IL1A
49 11.73 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
50 11.69 CCL2 IL18 IL1B IL6 TNF

GO Terms for Stachybotrys Chartarum

Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
2 extracellular space GO:0005615 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.99 CCL2 CCL3 CCL4 CCL5 CCL7
2 cellular response to interferon-gamma GO:0071346 9.97 CCL2 CCL3 CCL4 CCL5 CCL7
3 cellular response to interleukin-1 GO:0071347 9.96 CCL2 CCL3 CCL4 CCL5 CCL7
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.95 CCL5 IL18 IL3 IL6 LIF
5 cell chemotaxis GO:0060326 9.94 CCL2 CCL3 CCL5 CXCL2
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL1B IL6 TNF
7 regulation of cell shape GO:0008360 9.92 CCL2 CCL3 CCL7
8 cellular response to lipopolysaccharide GO:0071222 9.92 CCL2 IL6 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 CCL5 IL18 IL6 TNF
10 cellular response to organic cyclic compound GO:0071407 9.91 CCL2 CCL3 CCL5 IL18 IL1B TNF
11 response to virus GO:0009615 9.9 CCL4 CCL5 TNF
12 positive regulation of DNA binding transcription factor activity GO:0051091 9.9 IL1B IL6 TNF
13 response to toxic substance GO:0009636 9.9 CCL3 CCL4 CCL5
14 positive regulation of interleukin-6 production GO:0032755 9.9 IL1A IL1B IL6 TNF
15 cellular calcium ion homeostasis GO:0006874 9.89 CCL3 CCL5 CCL7
16 protein kinase B signaling GO:0043491 9.89 CCL2 CCL3 CCL5 IL1B TNF
17 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 IL3 IL6 LIF
18 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 LIF TNF
19 chemokine-mediated signaling pathway GO:0070098 9.88 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
20 regulation of insulin secretion GO:0050796 9.87 CCL5 IL1B TNF
21 positive regulation of T cell proliferation GO:0042102 9.85 CCL5 IL1B IL6
22 humoral immune response GO:0006959 9.85 CCL2 IL6 TNF
23 neutrophil chemotaxis GO:0030593 9.85 CCL2 CCL3 CCL4 CCL5 CCL7 IL1B
24 positive regulation of interferon-gamma production GO:0032729 9.84 IL18 IL1B TNF
25 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 IL1A IL1B TNF
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.82 IL18 IL1B TNF
27 positive regulation of calcium ion transport GO:0051928 9.82 CCL3 CCL4 CCL5
28 macrophage chemotaxis GO:0048246 9.8 CCL2 CCL3 CCL5
29 negative regulation by host of viral transcription GO:0043922 9.8 CCL3 CCL4 CCL5
30 monocyte chemotaxis GO:0002548 9.8 CCL2 CCL3 CCL4 CCL5 CCL7 IL6
31 eosinophil chemotaxis GO:0048245 9.78 CCL3 CCL5 CCL7
32 immune response GO:0006955 9.77 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
33 fever generation GO:0001660 9.76 IL1A IL1B IL3
34 positive regulation of natural killer cell chemotaxis GO:2000503 9.76 CCL3 CCL4 CCL5 CCL7
35 positive regulation of osteoclast differentiation GO:0045672 9.75 CSF1 TNF
36 positive regulation of chemokine production GO:0032722 9.74 IL6 TNF
37 positive regulation of JAK-STAT cascade GO:0046427 9.74 CCL5 IL6
38 negative regulation of lipid catabolic process GO:0050995 9.74 IL1B TNF
39 positive regulation of calcium-mediated signaling GO:0050850 9.74 CCL3 CCL4
40 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.74 CSF1 IL18
41 positive regulation of calcium ion import GO:0090280 9.73 CCL2 CCL3
42 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
43 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
44 positive regulation of macrophage differentiation GO:0045651 9.73 CSF1 LIF
45 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 CCL2 CCL3 CCL5 IL18 IL1B TNF
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
47 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
48 positive regulation of macrophage chemotaxis GO:0010759 9.72 CCL5 CSF1
49 neutrophil activation GO:0042119 9.71 CCL5 IL18
50 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.71 IL1A IL1B

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.67 CSF1 IL3 IL6 LIF
2 interleukin-1 receptor binding GO:0005149 9.5 IL1A IL1B IL3
3 cytokine activity GO:0005125 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
4 CCR1 chemokine receptor binding GO:0031726 9.46 CCL3 CCL4 CCL5 CCL7
5 phospholipase activator activity GO:0016004 9.43 CCL3 CCL5
6 CCR5 chemokine receptor binding GO:0031730 9.43 CCL3 CCL4 CCL5
7 chemokine activity GO:0008009 9.43 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
8 CCR2 chemokine receptor binding GO:0031727 9.4 CCL2 CCL7
9 protein binding GO:0005515 10.27 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1

Sources for Stachybotrys Chartarum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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