MCID: STC004
MIFTS: 35

Stachybotrys Chartarum malady

Rare diseases category

Aliases & Classifications for Stachybotrys Chartarum

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Aliases & Descriptions for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 45
 
Stachybotrys Atra 45


Classifications:



Summaries for Stachybotrys Chartarum

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Wikipedia:68 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards based summary: Stachybotrys Chartarum, also known as stachybotrys atra, is related to asthma and neuronitis. An important gene associated with Stachybotrys Chartarum is CCL7 (Chemokine (C-C Motif) Ligand 7), and among its related pathways are Hypertrophy Model and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are adipose tissue and muscle.

Related Diseases for Stachybotrys Chartarum

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Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1asthma29.2CCL3, CCL5, IL18, IL1A, IL1B, IL3
2neuronitis10.5
3hemosiderosis10.5
4sick building syndrome10.4
5pulmonary hemosiderosis10.4
6allergic asthma10.4
7rhinitis10.4
8diabetic cataract10.3IL1A, IL1B
9uterine sarcoma10.3CCL2, CCL7
10subserous uterine fibroid10.2CCL2, IL1B
11meckel's diverticulitis10.2IL1B, TNF
12stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.2IL1B, TNF
13peyronie's disease10.2IL1B, TNF
14waardenburg syndrome type 410.2IL1B, TNF
15best1 retinopathy10.2IL18, TNF
16diabetic ketoacidosis10.2IL1B, IL6
17calpainopathy10.1IL1B, TNF
18skin disease10.1IL1A, TNF
19meningoencephalocele10.1CCL5, IL1A, IL1B
20ischemia10.1IL1A, IL1B
21lymphoepithelioma-like carcinoma10.1IL1A, IL1B, TNF
22siderosis10.1CCL2, TNF
23chorioamnionitis10.1IL1B, IL6
24glycogen storage disease10.1CCL2, CSF1, IL1B
25clear cell renal cell carcinoma10.1IL1A, IL1B, TNF
26acute allergic serous otitis media10.1IL1A, IL1B, TNF
27lymphangioma10.1IL18, IL1B, TNF
28scleroderma10.1CCL2, TNF
29single ventricular heart10.1IL1A, IL1B, TNF
30glossopharyngeal nerve disease10.1IL1B, IL6
31splenic sequestration10.1IL1A, IL1B, TNF
32humero-ulnar synostosis10.1IL18, IL1B, IL6
33conventional central osteosarcoma10.1IL1A, IL1B, TNF
34rocky mountain spotted fever10.1CCL2, CCL4
35idiopathic neutropenia10.1CCL2, CCL5, IL1A
36transient refractive change10.1IL18, IL1B, IL6
37lens disease10.1IL1A, IL1B, TNF
38encephalomalacia10.1CCL2, CCL5, IL1B
39fibrogenesis imperfecta ossium10.0CCL2, IL18, TNF
40crohn's disease10.0IL6, TNF
41intervertebral disc disease10.0IL1A, IL1B, IL6
42aorta atresia10.0IL6, TNF
43microcystic adenoma10.0IL18, TNF
44malignant sertoli-leydig cell tumor of ovary10.0IL6, TNF
45renal oncocytoma10.0CCL2, IL18, TNF
46retinitis pigmentosa10.0CCL2, IL1B, IL6
47glycogen storage disease viii10.0IL6, TNF
48t cell immunodeficiency primary10.0IL6, TNF
49psoriatic arthritis10.0IL1A, IL1B, TNF
50acute disseminated encephalomyelitis10.0CCL2, IL18, IL6

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Symptoms for Stachybotrys Chartarum

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Drugs & Therapeutics for Stachybotrys Chartarum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

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Anatomical Context for Stachybotrys Chartarum

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MalaCards organs/tissues related to Stachybotrys Chartarum:

33
Lung, Testes, Monocytes, Brain, Colon

Animal Models for Stachybotrys Chartarum or affiliated genes

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MGI Mouse Phenotypes related to Stachybotrys Chartarum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8CCL2, IL18, IL6, LIF, TNF
2MP:00053698.4CCL2, CSF1, IL18, IL6, LIF, TNF
3MP:00053918.3CCL2, CSF1, IL18, IL6, LIF, TNF
4MP:00020068.3CCL2, IL1A, IL1B, IL3, IL6, TNF
5MP:00053818.0CCL2, CCL3, IL18, IL6, LIF, TNF
6MP:00053857.8CCL2, CSF1, IL18, IL1A, IL1B, IL6
7MP:00053766.4CCL2, CCL3, CSF1, IL18, IL1A, IL1B
8MP:00053975.9CCL2, CCL3, CCL5, CCL7, CSF1, IL18
9MP:00053875.6CCL2, CCL3, CCL5, CCL7, CSF1, IL18

Publications for Stachybotrys Chartarum

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Articles related to Stachybotrys Chartarum:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. (26036596)
2015
2
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. (24387683)
2014
3
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. (24139181)
2013
4
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. (22552393)
2012
5
Allergen of the month--Stachybotrys chartarum. (22626607)
2012
6
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. (21982832)
2011
7
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. (19796210)
2010
8
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. (20150440)
2010
9
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. (20077192)
2009
10
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. (20061240)
2009
11
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. (18007011)
2008
12
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. (17267247)
2007
13
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. (17186382)
2007
14
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). (17764432)
2007
15
Pulmonary cytotoxicity of secondary metabolites of Stachybotrys chartarum (Ehrenb.) Hughes. (17195998)
2006
16
The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity. (16436280)
2006
17
DNA damage, redox changes, and associated stress-inducible signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. (16476459)
2006
18
Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice. (16322647)
2006
19
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. (16754538)
2006
20
Interactions between Streptomyces californicus and Stachybotrys chartarum can induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages. (15667833)
2005
21
Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms. (15647601)
2005
22
Ultraviolet germicidal irradiation disinfection of Stachybotrys chartarum. (16391660)
2005
23
Antibodies against Stachybotrys chartarum extract and its antigenic components, Stachyhemolysin and Stachyrase-A: a new clinical biomarker. (15874884)
2005
24
Comparison of immunomodulator mRNA and protein expression in the lungs of Stachybotrys chartarum spore-exposed mice. (16020192)
2005
25
Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells. (15574675)
2005
26
Attributes of Stachybotrys chartarum and its association with human disease. (14767429)
2004
27
Wall relative humidity: a simple and reliable index for predicting Stachybotrys chartarum infestation in dwellings. (15104787)
2004
28
Protein translation inhibition by Stachybotrys chartarum conidia with and without the mycotoxin containing polysaccharide matrix. (15487326)
2004
29
Immunochemical Assay for Satratoxin G and other Macrocyclic Trichothecenes Associated with Indoor Air Contamination by Stachybotrys chartarum. (20021149)
2003
30
Molecular and phenotypic descriptions of Stachybotrys chlorohalonata sp. nov. and two chemotypes of Stachybotrys chartarum found in water-damaged buildings. (21149024)
2003
31
Effect of plasterboard composition on Stachybotrys chartarum growth and biological activity of spores. (12839740)
2003
32
Cryptic species in Stachybotrys chartarum. (21156555)
2002
33
Isolation and properties of stachyrase A, a chymotrypsin-like serine proteinase from Stachybotrys chartarum. (11748212)
2002
34
IgE-reactive proteins from Stachybotrys chartarum. (12141716)
2002
35
Stachylysin may be a cause of hemorrhaging in humans exposed to Stachybotrys chartarum. (11895972)
2002
36
Preliminary description of antigenic components characteristic of Stachybotrys chartarum. (11237513)
2001
37
Specific detection of Stachybotrys chartarum in pure culture using quantitative polymerase chain reaction. (11352593)
2001
38
Analysis of pulmonary surfactant by Fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) spores. (11245829)
2001
39
Stachybotrys chartarum: current knowledge of its role in disease. (11104457)
2000
40
The time course of responses to intratracheally instilled toxic Stachybotrys chartarum spores in rats. (11227851)
2000
41
Reduction of pulmonary toxicity of Stachybotrys chartarum spores by methanol extraction of mycotoxins. (10877773)
2000
42
Atranones A-G, from the toxigenic mold Stachybotrys chartarum. (11130678)
2000
43
Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: quantitative assessment before, during, and after remediation. (10741843)
2000
44
Quantification of siderophore and hemolysin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis. (10831457)
2000
45
Volatile sesquiterpenes from Stachybotrys chartarum: Indicators for trichothecene producing mold species? (19009424)
2000
46
Sanitation of wallboard colonized with Stachybotrys chartarum. (10387112)
1999
47
Respiratory effects in mice exposed to airborne emissions from Stachybotrys chartarum and implications for risk assessment. (9783329)
1998
48
Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment. (8738349)
1996
49
Some cultural conditions that control production of verrucarin J, a cytotoxic metabolite of Stachybotrys chartarum. (7202311)
1982
50
Discovery of toxicogenic Stachybotrys chartarum strains in Finland. (5013039)
1972

Variations for Stachybotrys Chartarum

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Expression for genes affiliated with Stachybotrys Chartarum

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Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

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Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL18, IL1A
29.7IL1B, IL6
39.5IL18, IL1A, IL1B
49.4IL18, IL1B, TNF
59.3CCL2, IL6, LIF
69.2IL1B, IL6, TNF
7
Apoptosis (KEGG)
Show member pathways
9.2IL1B, IL6, TNF
89.1CSF1, IL1A, IL1B, TNF
98.9CCL5, IL1A, IL1B, IL6
108.9IL18, IL1B, IL6, TNF
11
Show member pathways
8.9IL18, IL1B, IL6, TNF
128.9IL1A, IL1B, IL6, TNF
138.9IL1A, IL1B, IL6, TNF
14
Show member pathways
8.9IL1A, IL1B, IL6, TNF
158.9IL1A, IL1B, IL6, TNF
168.9IL1A, IL1B, IL6, TNF
17
B cell receptor signaling pathway (KEGG)
Show member pathways
8.9IL1A, IL1B, IL6, TNF
18
Show member pathways
8.9CCL2, IL1B, IL6, TNF
198.8CCL2, CSF1, IL18, IL1B, TNF
208.7CCL2, CCL5, IL1B, IL3, TNF
21
Show member pathways
8.7CCL3, CCL4, TNF
22
Show member pathways
8.6IL1A, IL1B, IL3, IL6, TNF
238.6CCL4, CXCL2, IL1B, TNF
248.6IL18, IL1A, IL1B, IL6, TNF
25
Show member pathways
8.6IL18, IL1A, IL1B, IL6, TNF
26
Show member pathways
8.5CCL3, CCL4, IL18, IL1B
27
Show member pathways
8.5CCL2, IL18, IL1B, IL6, TNF
288.5CCL2, IL18, IL1B, IL6, TNF
29
Show member pathways
8.4CCL4, CCL5, IL18, IL1B, IL6
308.3CSF1, IL1A, IL1B, IL3, IL6, TNF
31
Show member pathways
8.3IL18, IL1A, IL1B, IL3, IL6, TNF
32
Show member pathways
8.3IL18, IL1A, IL1B, IL3, IL6, TNF
338.3CXCL2, IL18, IL1B, IL6, TNF
348.3CCL3, IL1A, IL1B, IL3, IL6
358.3CCL2, CCL3, CSF1, IL1B, TNF
368.0CSF1, CXCL2, IL1A, IL1B, IL6, TNF
377.9CCL2, CXCL2, IL1A, IL1B, IL6, TNF
38
Show member pathways
7.8CCL2, CCL5, IL18, IL1A, IL1B, IL6
39
Show member pathways
7.5CCL2, CCL5, CXCL2, IL18, IL1B, IL6
40
Show member pathways
7.5CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
41
Show member pathways
7.5CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
427.2CCL2, CCL5, CSF1, CXCL2, IL1B, IL6
43
Show member pathways
7.1CCL2, CCL3, CCL4, CCL5, IL1B, IL6
44
Salmonella infection (KEGG)
Show member pathways
7.1CCL2, CCL3, CCL4, CCL5, IL1B, IL6
456.7CCL2, CCL3, CCL5, CSF1, IL18, IL1A
46
Show member pathways
5.9CCL2, CCL3, CCL4, CCL5, CCL7, IL18
47
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
48
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
49
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
50
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

GO Terms for genes affiliated with Stachybotrys Chartarum

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Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055764.7CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
2extracellular spaceGO:00056154.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:000166010.6IL1A, IL1B
2sequestering of triglycerideGO:003073010.5IL1B, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
4chronic inflammatory response to antigenic stimulusGO:000243910.4IL1B, TNF
5cellular response to high density lipoprotein particle stimulusGO:007140310.3CCL2, CCL5
6response to gamma radiationGO:001033210.3CCL2, CCL7, IL1B
7positive regulation of interferon-gamma productionGO:003272910.1IL18, IL1B, TNF
8positive regulation of NF-kappaB import into nucleusGO:004234610.1IL18, IL1B, TNF
9positive regulation of fever generationGO:003162210.0CCL5, IL1B, TNF
10positive regulation of macrophage chemotaxisGO:00107599.9CCL2, CCL5, CSF1
11positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL18, IL6, LIF
12positive regulation of osteoclast differentiationGO:00456729.8CCL5, CSF1, TNF
13positive regulation of interleukin-6 productionGO:00327559.6IL1B, IL6, TNF
14response to heatGO:00094089.6CCL2, IL1B, IL6
15positive regulation of cell adhesionGO:00457859.6CCL2, CCL5, TNF
16positive regulation of nitric oxide biosynthetic processGO:00454299.5IL1B, IL6, TNF
17response to bacteriumGO:00096179.5CCL2, CCL5, IL6
18macrophage chemotaxisGO:00482469.4CCL2, CCL3, CCL5
19lymphocyte chemotaxisGO:00482479.4CCL2, CCL3, CCL5
20negative regulation by host of viral transcriptionGO:00439229.3CCL3, CCL4, CCL5
21positive regulation of calcium ion transportGO:00519289.3CCL3, CCL4, CCL5
22positive regulation of tumor necrosis factor productionGO:00327609.2CCL2, CCL3, CCL4
23negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.1IL1A, IL1B, TNF
24positive regulation of cell migrationGO:00303359.0CCL3, CCL5, CCL7, CSF1
25positive regulation of natural killer cell chemotaxisGO:20005039.0CCL3, CCL4, CCL5, CCL7
26response to glucocorticoidGO:00513849.0CCL2, CCL5, IL1B, IL6, TNF
27positive regulation of inflammatory responseGO:00507299.0CCL3, CCL4, CCL5, IL18
28agingGO:00075688.9CCL2, CCL5, IL1B, IL6
29cellular calcium ion homeostasisGO:00068748.9CCL2, CCL3, CCL5, CCL7
30regulation of cell shapeGO:00083608.8CCL2, CCL3, CCL7, IL6
31cytokine-mediated signaling pathwayGO:00192218.8CCL2, IL1A, IL1B, IL3, IL6
32protein kinase B signalingGO:00434918.8CCL2, CCL3, CCL5, IL1B, TNF
33response to lipopolysaccharideGO:00324968.7CCL2, CCL5, CXCL2, IL1B, IL6
34eosinophil chemotaxisGO:00482458.7CCL2, CCL3, CCL4, CCL5, CCL7
35cellular response to lipopolysaccharideGO:00712228.6CCL2, CCL5, IL18, IL1B, IL6, TNF
36cellular response to interferon-gammaGO:00713468.5CCL2, CCL3, CCL4, CCL5, CCL7
37lipopolysaccharide-mediated signaling pathwayGO:00316638.4CCL2, CCL3, CCL5, IL18, IL1B, TNF
38chemotaxisGO:00069358.4CCL2, CCL3, CCL5, CCL7, CXCL2
39cellular response to organic cyclic compoundGO:00714078.2CCL2, CCL3, CCL5, IL18, IL1B, TNF
40neutrophil chemotaxisGO:00305938.2CCL2, CCL3, CCL4, CCL5, CCL7, IL1B
41monocyte chemotaxisGO:00025488.2CCL2, CCL3, CCL4, CCL5, CCL7, IL6
42cell-cell signalingGO:00072678.1CCL3, CCL4, CCL5, CCL7, IL18, IL1B
43cellular response to interleukin-1GO:00713478.0CCL2, CCL3, CCL4, CCL5, CCL7, IL6
44cellular response to tumor necrosis factorGO:00713568.0CCL2, CCL3, CCL4, CCL5, CCL7, IL6
45chemokine-mediated signaling pathwayGO:00700987.9CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
46MAPK cascadeGO:00001657.6CCL2, CCL3, CCL5, IL18, IL1B, IL3
47positive regulation of ERK1 and ERK2 cascadeGO:00703746.7CCL2, CCL3, CCL4, CCL5, CCL7, IL1A
48positive regulation of gene expressionGO:00106286.6CCL3, CCL5, CSF1, IL18, IL1A, IL1B
49inflammatory responseGO:00069545.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
50immune responseGO:00069555.4CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:003172710.4CCL2, CCL7
2interleukin-1 receptor bindingGO:000514910.3IL1A, IL1B
3phospholipase activator activityGO:00160049.6CCL3, CCL5
4CCR5 chemokine receptor bindingGO:00317309.1CCL3, CCL4, CCL5
5CCR1 chemokine receptor bindingGO:00317268.9CCL3, CCL4, CCL5, CCL7
6growth factor activityGO:00080838.8CSF1, IL3, IL6, LIF
7chemokine activityGO:00080097.5CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
8cytokine activityGO:00051257.4CCL4, CSF1, IL18, IL1A, IL1B, IL3

Sources for Stachybotrys Chartarum

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet