MCID: STC004
MIFTS: 38

Stachybotrys Chartarum malady

Category: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

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Aliases & Descriptions for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 46
 
Stachybotrys Atra 46

Classifications:



Summaries for Stachybotrys Chartarum

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Wikipedia:69 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards based summary: Stachybotrys Chartarum, also known as stachybotrys atra, is related to asthma and diabetic cataract. An important gene associated with Stachybotrys Chartarum is CCL7 (C-C Motif Chemokine Ligand 7), and among its related pathways are Interleukin-1 processing and Cellular roles of Anthrax toxin. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are integument and cardiovascular system.

Related Diseases for Stachybotrys Chartarum

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Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1asthma27.0CCL3, CCL5, IL18, IL1A, IL1B, IL3
2diabetic cataract10.7IL1A, IL1B
3silo filler's disease10.6IL18, IL1B
4thyroid malformation10.6IL1B, TNF
5mental retardation anophthalmia craniosynostosis10.6IL1A, IL1B
6hyperparathyroidism10.5CCL2, IL1B
7hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.5IL1B, TNF
8baetz-greenwalt syndrome10.5IL1B, TNF
9pulmonary hypertension10.5IL1B, TNF
10peri-anal fistula10.4IL1A, IL1B
11corneal deposit10.4IL1B, IL6
12warm antibody hemolytic anemia10.4IL1B, TNF
13tarsal tunnel syndrome10.4IL1B, IL6
14waterhouse-friderichsen syndrome10.4CCL4, CCL5
15small intestine lymphoma10.3IL1A, TNF
16askin's tumor10.3CCL2, IL1A, IL1B
17cartilage disease10.3IL1B, TNF
18exophthalmos10.3CCL7, IL3, TNF
19hemosiderosis10.3
20neuronitis10.3
21rectosigmoid junction neoplasm10.3IL1A, IL1B, TNF
22hemoglobinopathy10.2IL1B, IL6
23pseudoretinitis pigmentosa10.2IL1A, IL1B, TNF
24keratosis10.2IL18, IL1B, TNF
25anterior dislocation of lens10.2CSF1, IL6
26melorheostosis10.2IL1B, IL6
27midline interhemispheric variant of holoprosencephaly10.2IL18, IL1B, IL6
28syphilitic encephalitis10.2IL18, IL1B, IL6
29pulmonary hemosiderosis10.2
30sick building syndrome10.2
31rhinitis10.2
32allergic asthma10.2
33lethal midline granuloma10.2IL1A, IL1B, TNF
34orbital plasma cell granuloma10.1CCL5, CCL7
35periodic paralyses10.1IL1A, IL1B, IL6
36infancy electroclinical syndrome10.1IL1B, IL6
37panner disease10.1IL6, TNF
38intervertebral disc disease10.1IL1A, IL1B, IL6
39aortic arch interruption10.1IL6, TNF
40cutaneous leishmaniasis10.1IL6, TNF
41leprosy 410.1IL1A, IL1B, TNF
42blind hypotensive eye10.1CCL5, IL1B, TNF
43renal tubular acidosis10.1CCL2, IL18, TNF
44maligant granulosa cell tumor of ovary10.1IL6, TNF
45tricho odonto onycho dermal syndrome10.1IL6, TNF
46vibrio vulnificus infection10.1CCL2, IL6
47pseudohypoaldosteronism, type iid10.1CCL5, CCL7, IL18
48granuloma annulare10.0CCL2, CSF1, TNF
49gonococcal synovitis10.0CCL2, TNF
50scrotum melanoma10.0CCL2, IL18, IL6

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Symptoms for Stachybotrys Chartarum

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Drugs & Therapeutics for Stachybotrys Chartarum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

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Anatomical Context for Stachybotrys Chartarum

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MalaCards organs/tissues related to Stachybotrys Chartarum:

34
Lung, Testes, Monocytes, Brain, Colon

Animal Models for Stachybotrys Chartarum or affiliated genes

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MGI Mouse Phenotypes related to Stachybotrys Chartarum:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2CSF1, IL18, IL1A, IL1B, IL6, LIF
2MP:00053857.4CSF1, CXCL2, IL18, IL1A, IL1B, IL6
3MP:00053877.2CCL2, CCL5, CSF1, IL18, IL1A, IL1B

Publications for Stachybotrys Chartarum

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Articles related to Stachybotrys Chartarum:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. (27148627)
2016
2
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. (27476483)
2016
3
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. (24387683)
2014
4
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. (25346283)
2014
5
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. (23180821)
2013
6
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. (21505872)
2011
7
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. (20150440)
2010
8
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. (20077192)
2009
9
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. (19459771)
2009
10
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. (18041646)
2008
11
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. (18460072)
2008
12
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. (17267247)
2007
13
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. (17420079)
2007
14
Pulmonary cytotoxicity of secondary metabolites of Stachybotrys chartarum (Ehrenb.) Hughes. (17195998)
2006
15
The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity. (16436280)
2006
16
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. (16754538)
2006
17
Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. (16882529)
2006
18
Interactions between Streptomyces californicus and Stachybotrys chartarum can induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages. (15667833)
2005
19
Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms. (15647601)
2005
20
Antibodies against Stachybotrys chartarum extract and its antigenic components, Stachyhemolysin and Stachyrase-A: a new clinical biomarker. (15874884)
2005
21
Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells. (15574675)
2005
22
The Pathogenicity of Stachybotrys chartarum. (15864257)
2005
23
Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins on particulates smaller than conidia. (15640178)
2005
24
Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins in the indoor environment. (16269780)
2005
25
Attributes of Stachybotrys chartarum and its association with human disease. (14767429)
2004
26
Protein translation inhibition by Stachybotrys chartarum conidia with and without the mycotoxin containing polysaccharide matrix. (15487326)
2004
27
Immunochemical Assay for Satratoxin G and other Macrocyclic Trichothecenes Associated with Indoor Air Contamination by Stachybotrys chartarum. (20021149)
2003
28
Molecular and phenotypic descriptions of Stachybotrys chlorohalonata sp. nov. and two chemotypes of Stachybotrys chartarum found in water-damaged buildings. (21149024)
2003
29
Histological, immunohistochemical and morphometric changes in lung tissue in juvenile mice experimentally exposed to Stachybotrys chartarum spores. (12733633)
2003
30
Stachybotrys chartarum (chartarum = atra = alternans) and other problems caused by allergenic fungi. (12635571)
2003
31
Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective. (12525430)
2003
32
Cryptic species in Stachybotrys chartarum. (21156555)
2002
33
IgE-reactive proteins from Stachybotrys chartarum. (12141716)
2002
34
An extract of Stachybotrys chartarum causes allergic asthma-like responses in a BALB/c mouse model. (12388839)
2002
35
Effects of aerosols from nontoxic Stachybotrys chartarum on murine airways. (12028806)
2002
36
A Stachybotrys chartarum isolate from soybean. (12041871)
2002
37
Preliminary description of antigenic components characteristic of Stachybotrys chartarum. (11237513)
2001
38
Analysis of pulmonary surfactant by Fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) spores. (11245829)
2001
39
Stachybotrys chartarum: current knowledge of its role in disease. (11104457)
2000
40
Atranones A-G, from the toxigenic mold Stachybotrys chartarum. (11130678)
2000
41
Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: quantitative assessment before, during, and after remediation. (10741843)
2000
42
Quantification of siderophore and hemolysin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis. (10831457)
2000
43
Volatile sesquiterpenes from Stachybotrys chartarum: Indicators for trichothecene producing mold species? (19009424)
2000
44
Sick building syndrome. III. Stachybotrys chartarum. (10805208)
2000
45
Sanitation of wallboard colonized with Stachybotrys chartarum. (10387112)
1999
46
Hemolysis, toxicity, and randomly amplified polymorphic DNA analysis of Stachybotrys chartarum strains. (10388719)
1999
47
Quantitative measurement of Stachybotrys chartarum conidia using real time detection of PCR products with the TaqMan(TM)fluorogenic probe system. (10508554)
1999
48
Stachybotrys chartarum (atra) contamination of the indoor environment: Health implications. (20212975)
1999
49
Identification of putative sequence specific PCR primers for detection of the toxigenic fungal species Stachybotrys chartarum. (9843656)
1998
50
Discovery of toxicogenic Stachybotrys chartarum strains in Finland. (5013039)
1972

Variations for Stachybotrys Chartarum

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Expression for genes affiliated with Stachybotrys Chartarum

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Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

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Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL18, IL1A, IL1B
29.4IL18, IL1B, TNF
39.3CCL2, IL6, LIF
49.1CSF1, IL1A, IL1B, TNF
58.9CSF1, IL3, IL6, TNF
68.9CCL5, IL1A, IL1B, IL6
78.9CSF1, IL1B, IL6, TNF
88.9IL18, IL1B, IL6, TNF
9
Show member pathways
8.9IL18, IL1B, IL6, TNF
108.9IL1A, IL1B, IL6, TNF
118.9IL1A, IL1B, IL6, TNF
12
Show member pathways
8.9IL1A, IL1B, IL6, TNF
138.9IL1A, IL1B, IL6, TNF
148.9IL1A, IL1B, IL6, TNF
15
Show member pathways
8.9CCL2, IL1B, IL6, TNF
168.8CCL2, CSF1, IL18, IL1B, TNF
178.7CCL2, CCL5, IL1B, IL3, TNF
18
Show member pathways
8.7CCL3, CCL4, TNF
19
Show member pathways
8.6IL1A, IL1B, IL3, IL6, TNF
208.6CCL3, IL18, IL1B, TNF
218.6CCL4, CXCL2, IL1B, TNF
228.6IL18, IL1A, IL1B, IL6, TNF
23
Show member pathways
8.5CCL3, CCL4, IL18, IL1B
248.5CCL2, IL18, IL1B, IL6, TNF
25
Show member pathways
8.5CCL2, IL18, IL1B, IL6, TNF
268.5CCL2, IL1A, IL1B, IL6, TNF
27
Show member pathways
8.4CCL4, CCL5, IL18, IL1B, IL6
288.3CSF1, IL1A, IL1B, IL3, IL6, TNF
29
Show member pathways
8.3IL18, IL1A, IL1B, IL3, IL6, TNF
30
Show member pathways
8.3IL18, IL1A, IL1B, IL3, IL6, TNF
318.3CXCL2, IL18, IL1B, IL6, TNF
328.3CCL3, IL1A, IL1B, IL3, IL6
338.3CCL2, CCL3, CSF1, IL1B, TNF
348.0CSF1, CXCL2, IL1A, IL1B, IL6, TNF
357.9CCL2, CXCL2, IL1A, IL1B, IL6, TNF
36
Show member pathways
7.8CCL2, CCL5, IL18, IL1A, IL1B, IL6
37
Show member pathways
7.5CCL2, CCL5, CXCL2, IL18, IL1B, IL6
38
Show member pathways
7.5CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
39
Show member pathways
7.5CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
407.2CCL2, CCL5, CSF1, CXCL2, IL1B, IL6
41
Show member pathways
7.1CCL2, CCL3, CCL4, CCL5, IL1B, IL6
42
Show member pathways
7.1CCL3, CCL4, CXCL2, IL18, IL1A, IL1B
436.7CCL2, CCL3, CCL5, CSF1, IL18, IL1A
44
Show member pathways
6.4CCL2, CCL3, CCL4, CCL5, CCL7, IL18
45
Show member pathways
5.9CCL2, CCL3, CCL4, CCL5, CCL7, IL18
46
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
47
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
48
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
49
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
504.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

GO Terms for genes affiliated with Stachybotrys Chartarum

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Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055764.7CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
2extracellular spaceGO:00056154.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:000166010.6IL1A, IL1B
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
3sequestering of triglycerideGO:003073010.5IL1B, TNF
4chronic inflammatory response to antigenic stimulusGO:000243910.5IL1B, TNF
5cellular response to high density lipoprotein particle stimulusGO:007140310.4CCL2, CCL5
6regulation of vascular endothelial growth factor productionGO:001057410.3CCL2, IL6
7epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.2IL6, TNF
8response to gamma radiationGO:001033210.1CCL2, CCL7, IL1B
9positive regulation of NF-kappaB import into nucleusGO:004234610.1IL18, IL1B, TNF
10positive regulation of interferon-gamma productionGO:003272910.1IL18, IL1B, TNF
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1A, IL1B, TNF
12positive regulation of macrophage chemotaxisGO:001075910.0CCL2, CCL5, CSF1
13positive regulation of fever generationGO:003162210.0CCL5, IL1B, TNF
14positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.0IL18, IL6, LIF
15positive regulation of osteoclast differentiationGO:00456729.9CCL5, CSF1, TNF
16positive regulation of cell adhesionGO:00457859.8CCL2, CCL5, TNF
17humoral immune responseGO:00069599.8CCL2, IL6, TNF
18eosinophil chemotaxisGO:00482459.7CCL3, CCL5, CCL7
19response to heatGO:00094089.6CCL2, IL1B, IL6
20positive regulation of nitric oxide biosynthetic processGO:00454299.6IL1B, IL6, TNF
21lymphocyte chemotaxisGO:00482479.5CCL2, CCL3, CCL5
22macrophage chemotaxisGO:00482469.5CCL2, CCL3, CCL5
23negative regulation by host of viral transcriptionGO:00439229.4CCL3, CCL4, CCL5
24positive regulation of interleukin-6 productionGO:00327559.3IL1A, IL1B, IL6, TNF
25positive regulation of calcium ion transportGO:00519289.3CCL3, CCL4, CCL5
26response to glucocorticoidGO:00513849.3CCL2, CCL5, IL6, TNF
27agingGO:00075689.2CCL2, CCL5, IL1B, IL6
28cytokine-mediated signaling pathwayGO:00192219.2CCL2, IL1A, IL1B, IL3, IL6
29positive regulation of natural killer cell chemotaxisGO:20005039.1CCL3, CCL4, CCL5, CCL7
30regulation of cell shapeGO:00083608.9CCL2, CCL3, CCL7, IL6
31positive regulation of cell migrationGO:00303358.9CCL3, CCL5, CCL7, CSF1
32protein kinase B signalingGO:00434918.8CCL2, CCL3, CCL5, IL1B, TNF
33cellular calcium ion homeostasisGO:00068748.6CCL2, CCL3, CCL5, CCL7
34cellular response to interferon-gammaGO:00713468.6CCL2, CCL3, CCL4, CCL5, CCL7
35lipopolysaccharide-mediated signaling pathwayGO:00316638.5CCL2, CCL3, CCL5, IL18, IL1B, TNF
36chemotaxisGO:00069358.4CCL2, CCL3, CCL5, CCL7, CXCL2
37positive regulation of inflammatory responseGO:00507298.4CCL2, CCL3, CCL4, CCL5, CCL7, IL18
38neutrophil chemotaxisGO:00305938.4CCL2, CCL3, CCL4, CCL5, CCL7, IL1B
39cellular response to organic cyclic compoundGO:00714078.3CCL2, CCL3, CCL5, IL18, IL1B, TNF
40immune responseGO:00069558.3CCL4, CXCL2, IL18, IL1A, IL3, LIF
41monocyte chemotaxisGO:00025488.2CCL2, CCL3, CCL4, CCL5, CCL7, IL6
42cellular response to interleukin-1GO:00713478.1CCL2, CCL3, CCL4, CCL5, CCL7, IL6
43cellular response to tumor necrosis factorGO:00713568.1CCL2, CCL3, CCL4, CCL5, CCL7, IL6
44cell-cell signalingGO:00072678.1CCL3, CCL4, CCL5, CCL7, IL18, IL1B
45MAPK cascadeGO:00001658.0CCL2, CCL3, CCL5, IL18, IL1B, IL3
46chemokine-mediated signaling pathwayGO:00700988.0CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
47positive regulation of GTPase activityGO:00435477.9CCL2, CCL3, CCL4, CCL5, CCL7, IL3
48positive regulation of gene expressionGO:00106287.4CCL3, CSF1, IL18, IL1A, IL1B, IL6
49positive regulation of ERK1 and ERK2 cascadeGO:00703746.9CCL2, CCL3, CCL4, CCL5, CCL7, IL1B
50inflammatory responseGO:00069545.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:000514910.4IL1A, IL1B
2CCR2 chemokine receptor bindingGO:003172710.3CCL2, CCL7
3phospholipase activator activityGO:00160049.7CCL3, CCL5
4growth factor activityGO:00080839.1CSF1, IL3, IL6, LIF
5CCR5 chemokine receptor bindingGO:00317309.1CCL3, CCL4, CCL5
6CCR1 chemokine receptor bindingGO:00317268.9CCL3, CCL4, CCL5, CCL7
7chemokine activityGO:00080097.5CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
8cytokine activityGO:00051256.5CCL2, CCL4, CSF1, IL18, IL1A, IL1B

Sources for Stachybotrys Chartarum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet