MCID: STC004
MIFTS: 39

Stachybotrys Chartarum malady

Summaries for Stachybotrys Chartarum

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64Wikipedia, 33MalaCards
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Wikipedia:64 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards: Stachybotrys Chartarum, also known as stachybotrys atra, is related to allergic asthma and asthma. An important gene associated with Stachybotrys Chartarum is CCL7 (chemokine (C-C motif) ligand 7), and among its related pathways are Rheumatoid arthritis and Cytokines and Inflammatory Response. The compounds gm-csf and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, colon and lung, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Aliases & Classifications for Stachybotrys Chartarum

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

stachybotrys chartarum 43
stachybotrys atra 43


Related Diseases for Stachybotrys Chartarum

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Clinical Features for Stachybotrys Chartarum

Drugs & Therapeutics for Stachybotrys Chartarum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Stachybotrys Chartarum

Anatomical Context for Stachybotrys Chartarum

Sources:
33MalaCards
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MalaCards organs/tissues related to Stachybotrys Chartarum:

33
Brain, Colon, Lung, Monocytes, Fetal brain, Fetal lung

Animal Models for Stachybotrys Chartarum or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Stachybotrys Chartarum:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5CSF1, LIF, IL3, IL18, IL1A, IL1B
2MP:00053977.4CCL3, CCL7, CSF1, LIF, IL3, IL18
3MP:00053877.1IL1B, CCL3, CCL7, CSF1, LIF, IL3

Publications for Stachybotrys Chartarum

Sources:
51PubMed
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Articles related to Stachybotrys Chartarum:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Allergen of the month--Stachybotrys chartarum. (22626607)
2012
2
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. (17186382)
2007
3
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). (17764432)
2007
4
Comparison of four different methods for extraction of Stachybotrys chartarum spore DNA and verification by real-time PCR. (17499865)
2007
5
An in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells. (17411351)
2007
6
DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins. (17534970)
2007
7
Testing antimicrobial cleaner efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. (18062486)
2007
8
The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity. (16436280)
2006
9
DNA damage, redox changes, and associated stress-inducible signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. (16476459)
2006
10
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. (16754538)
2006
11
Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. (16835065)
2006
12
Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. (16882529)
2006
13
Solvent comparison in the isolation, solubilization, and toxicity of Stachybotrys chartarum spore trichothecene mycotoxins in an established in vitro luminescence protein translation inhibition assay. (16497399)
2006
14
Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins in the indoor environment. (16269780)
2005
15
Wall relative humidity: a simple and reliable index for predicting Stachybotrys chartarum infestation in dwellings. (15104787)
2004
16
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum. (15032487)
2004
17
Comparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strains. (14718650)
2004
18
Pulmonary effects of Stachybotrys chartarum in animal studies. (15350797)
2004
19
Immunochemical Assay for Satratoxin G and other Macrocyclic Trichothecenes Associated with Indoor Air Contamination by Stachybotrys chartarum. (20021149)
2003
20
Molecular and phenotypic descriptions of Stachybotrys chlorohalonata sp. nov. and two chemotypes of Stachybotrys chartarum found in water-damaged buildings. (21149024)
2003
21
Effect of plasterboard composition on Stachybotrys chartarum growth and biological activity of spores. (12839740)
2003
22
Immunocytochemical localization of stachylysin in Stachybotrys chartarum spores and spore-impacted mouse and rat lung tissue. (12733632)
2003
23
Stachybotrys chartarum: cause of human disease or media darling? (12964721)
2003
24
Intranasal exposure to a damp building mould, Stachybotrys chartarum, induces lung inflammation in mice by satratoxin-independent mechanisms. (14616875)
2003
25
Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective. (12525430)
2003
26
Cryptic species in Stachybotrys chartarum. (21156555)
2002
27
Isolation and properties of stachyrase A, a chymotrypsin-like serine proteinase from Stachybotrys chartarum. (11748212)
2002
28
IgE-reactive proteins from Stachybotrys chartarum. (12141716)
2002
29
Stachylysin may be a cause of hemorrhaging in humans exposed to Stachybotrys chartarum. (11895972)
2002
30
Volatile metabolites produced by three strains of Stachybotrys chartarum cultivated on rice and gypsum board. (12049433)
2002
31
Human pulmonary disease and exposure to Stachybotrys chartarum and other toxigenic fungi. (12185790)
2002
32
A Stachybotrys chartarum isolate from soybean. (12041871)
2002
33
Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarum. (12171446)
2002
34
Microanatomical changes in alveolar type II cells in juvenile mice intratracheally exposed to Stachybotrys chartarum spores and toxin. (11812928)
2002
35
Analysis of pulmonary surfactant by Fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) spores. (11245829)
2001
36
Effects of Stachybotrys chartarum on surfactant convertase activity in juvenile mice. (11264019)
2001
37
Reduction of pulmonary toxicity of Stachybotrys chartarum spores by methanol extraction of mycotoxins. (10877773)
2000
38
Atranones A-G, from the toxigenic mold Stachybotrys chartarum. (11130678)
2000
39
Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: quantitative assessment before, during, and after remediation. (10741843)
2000
40
Quantification of siderophore and hemolysin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis. (10831457)
2000
41
Sick building syndrome. III. Stachybotrys chartarum. (10805208)
2000
42
Sanitation of wallboard colonized with Stachybotrys chartarum. (10387112)
1999
43
Hemolysis, toxicity, and randomly amplified polymorphic DNA analysis of Stachybotrys chartarum strains. (10388719)
1999
44
Quantitative measurement of Stachybotrys chartarum conidia using real time detection of PCR products with the TaqMan(TM)fluorogenic probe system. (10508554)
1999
45
Identification of putative sequence specific PCR primers for detection of the toxigenic fungal species Stachybotrys chartarum. (9843656)
1998
46
Toxicity screening of materials from buildings with fungal indoor air quality problems (Stachybotrys chartarum). (23605062)
1998
47
Effects of Stachybotrys chartarum (atra) conidia and isolated toxin on lung surfactant production and homeostasis. (9851509)
1998
48
Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis in infants. (9758776)
1998
49
FR901459, a novel immunosuppressant isolated from Stachybotrys chartarum No. 19392. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities. (8294235)
1993
50
Some cultural conditions that control production of verrucarin J, a cytotoxic metabolite of Stachybotrys chartarum. (7202311)
1982

Genetic Variations for Stachybotrys Chartarum

Expression for genes affiliated with Stachybotrys Chartarum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stachybotrys Chartarum

Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 53R&D Systems, 12EMD Millipore
See all sources

Pathways related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL18
29.9CXCL2
39.6IL1B, IL18
4
Hide members
9.5IL1A, IL1B
5
Hide members
9.4CCL7, CCL4
69.2CSF1, IL18, IL1B
79.2IL18, IL1A, IL1B
89.2IL18, IL1A, IL1B
9
Hide members
9.2IL1B, IL1A, IL18
109.1CCL3, CCL4
119.1IL1B, IL1A, CSF1
12
Hide members
9.1IL1B, IL1A, IL3
13
Hide members
9.1IL1B, IL1A, IL3
149.1IL1B, CSF1, CCL3
159.0IL1B, IL18, CXCL2
16
Hide members
9.0IL1B, IL18, CXCL2
178.9CXCL2, IL1A, IL1B
188.8CCL4, IL18, IL1B
19
Hide members
8.7IL1B, IL1A, IL18, IL3
20
Hide members
8.7IL3, IL18, IL1A, IL1B
218.7IL1B, IL1A, IL18, IL3
22
Hide members
8.7IL1B, IL1A, IL18, IL3
238.7CSF1, IL3, IL1A, IL1B
248.6CSF1, LIF, CXCL2, IL1B
25
Hide members
8.6IL1B, CCL3, CCL4
268.5IL1B, CXCL2, CCL4
27
Hide members
8.3IL1B, IL18, CCL3, CCL4
288.2CCL4, CCL3, CCL7, CXCL2
29
Hide members
8.2CCL4, CCL3, CCL7, CXCL2
30
Hide members
8.2CCL4, CCL3, CCL7, CXCL2
31
Hide members
8.2CXCL2, CCL7, CCL3, CCL4
32
Hide members
8.0CCL3, CCL7, CSF1, LIF, CXCL2, IL18
337.2CCL4, CCL3, CXCL2, IL18, IL1A, IL1B
34
Hide members
7.1IL3, CXCL2, LIF, CSF1, CCL7, CCL3
35
Hide members
5.8IL1B, IL1A, IL18, IL3, CXCL2, LIF
36
Hide members
5.8CCL3, CCL4, CCL7, CSF1, IL1B, IL1A

Compounds for genes affiliated with Stachybotrys Chartarum

Sources:
45Novoseek, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.6LIF
2cycloheximide4510.6IL18
3hydrocortisone45 2 60 1113.5LIF
4indomethacin45 60 29 1113.5CSF1
5pge24510.3CXCL2
6endotoxin4510.0CXCL2, LIF
7anaphylatoxin459.6CCL7, IL3, IL1B
8cyclosporin a45 29 6011.5CCL3, IL3, LIF
9dexamethasone45 50 29 1112.3CCL7, LIF, CXCL2, IL3
10creatinine459.0CCL4, CSF1, IL1A
11poly(i-c)458.9CCL3, IL3, IL1B, IL18
12methylcellulose458.8CSF1, LIF, IL1A, IL3, CCL3
13larc458.7CCL4, CCL7, CCL3, IL1A
14tgf beta1458.7CSF1, CCL3, LIF, IL1B, IL18
15polyinosinic-polycytidylic acid458.7CSF1, IL18, IL1A, IL1B, CCL3
16pdtc458.6IL18, IL1B, CCL3, IL1A
175fluorouracil458.6LIF, CCL3, IL18, IL3, CSF1
18calcitriol45 60 11 2411.6LIF, IL3, IL1B, IL1A, CSF1
19h2o2458.6IL3, CXCL2, IL18, CCL3, LIF
20mip 1alpha458.6IL3, IL1B, CCL3, CCL4
21teck458.5CCL4, CCL3, CCL7
22ribonucleic acid458.4CCL3, CCL7, LIF, IL1A, IL1B
23genistein45 29 60 2 11 2413.4IL1A, CCL7, CSF1, LIF, IL1B, IL3
24ccl445 299.4CCL3, CCL4, CXCL2, CCL7
25leukotriene b445 60 2410.3IL1B, IL1A, IL3, CSF1, CCL7, CCL3
2612-o-tetradecanoylphorbol 13-acetate458.3CSF1, IL1A, IL3, LIF, CXCL2
27ivig458.3IL1B, IL1A, IL3, CSF1, CCL4
28neopterin458.3IL18, CCL3, CSF1, IL3, IL1A, IL1B
29heparin45 29 11 2411.2CCL4, CCL3, CSF1, IL1A, LIF
30lactate458.1CCL3, CXCL2, IL3, IL18, CSF1, LIF
31n acetylcysteine458.1CSF1, CXCL2, IL3, IL18, IL1B
32ly294002458.0CCL3, IL1B, IL18, CXCL2, IL3, CSF1
33fmlp458.0IL3, IL1A, CCL3, CSF1, CCL7, IL1B
34actinomycin d458.0LIF, CSF1, IL3, CCL7, IL1B, IL1A
35ionomycin457.9CCL4, IL18, IL3, IL1A, CCL3, CSF1
36thymidine45 248.9IL18, IL3, LIF, CSF1, IL1B, CCL3
37tarc457.8CCL3, CCL4, IL18, CCL7, CXCL2, IL1A
38prostaglandin457.7CSF1, CCL4, LIF, CXCL2, IL1A, IL1B
39wortmannin457.7LIF, CXCL2, IL3, CCL4, CSF1, CCL3
40histamine45 29 249.6IL1B, IL18, IL3, CSF1, CCL3, CCL4
41serine457.4IL1A, LIF, CCL3, CCL4, CXCL2, CSF1
42ccl345 298.3IL1A, IL1B, IL18, CXCL2, CCL7, CCL3
43groalpha457.3IL1B, IL1A, IL18, CXCL2, CCL7, CCL3
44sb 20358045 608.3CCL3, IL18, CCL4, LIF, CXCL2, IL1A
45nitric oxide45 11 249.1IL1B, CXCL2, IL18, LIF, CCL4, CCL3
46il 10457.1IL3, LIF, CSF1, CCL3, CCL4, IL1B
47retinoic acid45 248.1IL1B, IL18, CSF1, CCL4, IL3, IL1A
48pd 98,059457.0IL3, IL18, CCL3, CCL4, IL1B, CSF1
49vegf456.9IL1B, IL1A, LIF, CSF1, CCL3, CCL4
50rantes456.6CXCL2, IL3, IL1A, IL1B, LIF, CSF1

GO Terms for genes affiliated with Stachybotrys Chartarum

Sources:
16Gene Ontology
See all sources

Cellular components related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.5CCL3, CCL7, CXCL2, IL3, IL18, IL1A
2extracellular spaceGO:0056155.5IL1B, CCL4, CCL3, CCL7, CSF1, LIF

Biological processes related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage differentiationGO:04565110.1CSF1, LIF
2eosinophil chemotaxisGO:04824510.0CCL7, CCL3
3positive regulation of granulocyte macrophage colony-stimulating factor productionGO:0327259.9IL1B, IL18
4monocyte chemotaxisGO:0025489.9CCL7, CCL3
5fever generationGO:0016609.8IL1B, IL1A
6positive regulation of NF-kappaB import into nucleusGO:0423469.8IL18, IL1B
7positive regulation of interleukin-2 biosynthetic processGO:0450869.8IL1B, IL1A
8positive regulation of interleukin-8 productionGO:0327579.8IL1B, IL18
9positive regulation vascular endothelial growth factor productionGO:0105759.7IL1A, IL1B
10cellular response to interferon-gammaGO:0713469.7CCL3, IL18
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, IL1A
12positive regulation of tumor necrosis factor productionGO:0327609.6IL18, CCL3
13positive regulation of cell migrationGO:0303359.6CSF1, CCL7, CCL3
14positive regulation of gene expressionGO:0106289.5CCL3, CSF1, IL18
15lipopolysaccharide-mediated signaling pathwayGO:0316639.4IL1B, IL18, CCL3
16cellular response to organic cyclic compoundGO:0714079.4CCL3, IL18, IL1B
17MAPK cascadeGO:0001659.4CCL3, IL18, IL1B
18negative regulation by host of viral transcriptionGO:0439229.4CCL4, CCL3
19positive regulation of mitosisGO:0458409.4IL1B, IL1A
20positive regulation of calcium-mediated signalingGO:0508509.4CCL4, CCL3
21positive regulation of natural killer cell chemotaxisGO:20005039.2CCL7, CCL3, CCL4
22positive regulation of calcium ion transportGO:0519289.1CCL3, CCL4
23protein kinase B signaling cascadeGO:0434919.1IL1B, CCL3
24chemotaxisGO:0069358.6CCL4, CCL3, CCL7, CXCL2
25cell-cell signalingGO:0072677.9CCL4, CCL3, CCL7, IL3, IL18, IL1B
26immune responseGO:0069557.0CCL4, CCL7, LIF, CXCL2, IL3, IL18
27inflammatory responseGO:0069546.9IL1B, CCL4, CCL3, CCL7, CSF1, CXCL2

Molecular functions related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.4IL3, LIF, CSF1
2interleukin-1 receptor bindingGO:0051499.2IL1B, IL1A
3CCR5 chemokine receptor bindingGO:0317309.0CCL3, CCL4
4CCR1 chemokine receptor bindingGO:0317268.9CCL7, CCL3, CCL4
5chemokine activityGO:0080098.2CCL4, CCL3, CCL7, CXCL2
6cytokine activityGO:0051257.3IL1B, CCL4, CSF1, LIF, IL3, IL18

Products for genes affiliated with Stachybotrys Chartarum

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Sources for Stachybotrys Chartarum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet