MCID: STC004
MIFTS: 37

Stachybotrys Chartarum malady

Categories: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

Aliases & Descriptions for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 50
Stachybotrys Atra 50

Classifications:



Summaries for Stachybotrys Chartarum

MalaCards based summary : Stachybotrys Chartarum, also known as stachybotrys atra, is related to childhood malignant mesenchymoma and allergic bronchopulmonary aspergillosis. An important gene associated with Stachybotrys Chartarum is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, testes and monocytes, and related phenotypes are cardiovascular system and immune system

Wikipedia : 71 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

Related Diseases for Stachybotrys Chartarum

Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Related Disease Score Top Affiliating Genes
1 childhood malignant mesenchymoma 10.2 CCL5 IL3 IL6
2 allergic bronchopulmonary aspergillosis 10.2 CCL2 IL18 IL6
3 dyslexia 5 10.2 IL6 TNF
4 drug dependence 10.2 IL6 LIF TNF
5 oculomotor nerve paralysis 10.2 IL1B IL6
6 orthostatic proteinuria 10.2 IL18 IL6 TNF
7 common peroneal nerve lesion 10.2 IL1B IL6
8 red cell phospholipid defect with hemolysis 10.2 IL18 IL6 TNF
9 hemosiderosis 10.2
10 neuronitis 10.2
11 leydig cell hypoplasia 10.2 IL18 IL6 TNF
12 toxic optic neuropathy 10.2 IL1A IL1B
13 laryngotracheoesophageal cleft type 2 10.2 IL18 IL1B IL6
14 intussusception 10.2 IL1B TNF
15 aortic atherosclerosis 10.2 IL6 TNF
16 swine influenza 10.2 IL1A IL6 TNF
17 gastric leiomyoma 10.2 IL18 IL1B IL6
18 degenerative disc disease 10.2 IL6 TNF
19 primary ciliary dyskinesia 10.2 IL1A IL6 TNF
20 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 CCL5 IL6 TNF
21 mixed mineral dust pneumoconiosis 10.1 CCL2 CCL5 IL6
22 stiff-person syndrome 10.1 CCL2 CCL5 IL6
23 erb-duchenne and dejerine-klumpke palsies 10.1 CCL5 IL6 TNF
24 glucose intolerance 10.1 CCL2 IL18 TNF
25 stickler syndrome, type v 10.1 IL1A IL1B IL6
26 mansonelliasis 10.1 CCL5 IL6 TNF
27 oppositional defiant disorder 10.1 CCL2 IL6 TNF
28 amelogenesis imperfecta 10.1 CCL2 IL6 TNF
29 early yaws 10.1 CCL5 IL1B IL6
30 tau syndrome 10.1 IL18 IL1B TNF
31 neovascular glaucoma 10.1 CCL2 IL6 TNF
32 bipolar i disorder 10.1 IL1B IL6 TNF
33 mental retardation hypotonia skin hyperpigmentation 10.1 CCL5 IL1A IL1B
34 human immunodeficiency virus infectious disease 10.1 IL1B IL6 TNF
35 tinea capitis 10.1 IL1B IL6 TNF
36 measles 10.1 IL1B IL6 TNF
37 dextrocardia 10.1 IL1B IL6 TNF
38 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL1B IL6 TNF
39 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 IL1B IL6 TNF
40 stocco dos santos syndrome 10.1 IL1B TNF
41 gonococcal endophthalmia 10.1 IL1B IL6 TNF
42 ectodermal dysplasia bartalos type 10.1 IL1B IL6 TNF
43 migraine with aura 10.1 IL1B IL6 TNF
44 neuropathy 10.1 IL1B IL6 TNF
45 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.1 CCL2 IL6 TNF
46 splenic artery aneurysm 10.1 IL1B IL6 TNF
47 constant exophthalmos 10.1 CCL4 CCL5
48 labyrinthitis 10.1 IL1B IL6 TNF
49 pancreas lymphoma 10.1 IL1B IL6 TNF
50 blepharochalasis 10.1 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to Stachybotrys Chartarum

Symptoms & Phenotypes for Stachybotrys Chartarum

MGI Mouse Phenotypes related to Stachybotrys Chartarum:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 LIF TNF CSF1 CXCL2 IL18 IL1A
2 immune system MP:0005387 9.61 LIF TNF CCL2 CCL5 CSF1 IL18
3 integument MP:0010771 9.17 IL6 LIF TNF CSF1 IL18 IL1A

Drugs & Therapeutics for Stachybotrys Chartarum

Search Clinical Trials , NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

Anatomical Context for Stachybotrys Chartarum

MalaCards organs/tissues related to Stachybotrys Chartarum:

39
Lung, Testes, Monocytes, Brain, Colon

Publications for Stachybotrys Chartarum

Articles related to Stachybotrys Chartarum:

(show top 50) (show all 129)
id Title Authors Year
1
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. ( 27476483 )
2016
2
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. ( 27148627 )
2016
3
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. ( 27997578 )
2016
4
Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. ( 27097835 )
2016
5
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. ( 26036596 )
2015
6
Genome Sequence of Stachybotrys chartarum Strain 51-11. ( 26430036 )
2015
7
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. ( 24387683 )
2014
8
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. ( 25346283 )
2014
9
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. ( 23180821 )
2013
10
Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. ( 21384497 )
2013
11
Microbial volatile organic compound emissions from Stachybotrys chartarum growing on gypsum wallboard and ceiling tile. ( 24308451 )
2013
12
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. ( 24139181 )
2013
13
Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus Stachybotrys chartarum MXH-X73. ( 24308675 )
2013
14
Allergen of the month--Stachybotrys chartarum. ( 22626607 )
2012
15
Recurrence of Stachybotrys chartarum during mycological and toxicological study of bioaerosols collected in a dairy cattle shed. ( 22462447 )
2012
16
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. ( 22552393 )
2012
17
The influence of water activity and temperature on germination, growth and sporulation of Stachybotrys chartarum strains. ( 21347692 )
2011
18
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. ( 21505873 )
2011
19
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. ( 21982832 )
2011
20
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. ( 21505872 )
2011
21
Characterization of human antigenic proteins SchS21 and SchS34 from Stachybotrys chartarum. ( 21109751 )
2011
22
Pulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicity. ( 20385656 )
2010
23
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. ( 20150440 )
2010
24
The relative allergenicity of Stachybotrys chartarum compared to house dust mite extracts in a mouse model. ( 20235799 )
2010
25
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. ( 19796210 )
2010
26
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. ( 20077192 )
2009
27
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. ( 19459771 )
2009
28
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. ( 20061240 )
2009
29
Immunohistochemical and immunocytochemical detection of SchS34 antigen in Stachybotrys chartarum spores and spore impacted mouse lungs. ( 18046622 )
2008
30
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. ( 18007011 )
2008
31
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. ( 18460072 )
2008
32
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18041646 )
2008
33
Detection of Stachybotrys chartarum using rRNA, tri5, and beta-tubulin primers and determining their relative copy number by real-time PCR. ( 18499423 )
2008
34
Characterization of monoclonal antibodies to an antigenic protein from Stachybotrys chartarum and its measurement in house dust. ( 18242638 )
2008
35
DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins. ( 17534970 )
2007
36
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. ( 17186382 )
2007
37
Testing antimicrobial cleaner efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18062486 )
2007
38
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. ( 17420079 )
2007
39
The role of fungal proteinases in pathophysiology of Stachybotrys chartarum. ( 17610048 )
2007
40
Comparison of four different methods for extraction of Stachybotrys chartarum spore DNA and verification by real-time PCR. ( 17499865 )
2007
41
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. ( 17267247 )
2007
42
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). ( 17764432 )
2007
43
An in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells. ( 17411351 )
2007
44
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. ( 16754538 )
2006
45
DNA damage, redox changes, and associated stress-inducible signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. ( 16476459 )
2006
46
Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice. ( 16322647 )
2006
47
Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. ( 16882529 )
2006
48
Solvent comparison in the isolation, solubilization, and toxicity of Stachybotrys chartarum spore trichothecene mycotoxins in an established in vitro luminescence protein translation inhibition assay. ( 16497399 )
2006
49
Strain differences influence murine pulmonary responses to Stachybotrys chartarum. ( 16690987 )
2006
50
Co-cultivation of Streptomyces californicus and Stachybotrys chartarum stimulates the production of cytostatic compound(s) with immunotoxic properties. ( 17095029 )
2006

Variations for Stachybotrys Chartarum

Expression for Stachybotrys Chartarum

Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for Stachybotrys Chartarum

Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
2
Show member pathways
13.84 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
3
Show member pathways
13.66 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
4
Show member pathways
13.59 CCL2 CCL3 CCL4 CCL5 CCL7 IL18
5
Show member pathways
13.4 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
6
Show member pathways
13.38 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
7
Show member pathways
13.23 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
8
Show member pathways
13.07 CCL2 CCL5 CXCL2 IL18 IL1A IL1B
9
Show member pathways
13 CCL2 CCL3 CCL4 CCL5 IL1B IL6
10
Show member pathways
12.93 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
11
Show member pathways
12.9 CCL2 CCL5 IL18 IL1A IL1B IL6
12
Show member pathways
12.87 IL1A IL1B IL3 IL6 TNF
13
Show member pathways
12.81 CCL4 CCL5 IL18 IL1B IL6 TNF
14
Show member pathways
12.75 IL1A IL1B IL3 IL6 TNF
15
Show member pathways
12.66 IL18 IL1A IL1B IL6 TNF
16
Show member pathways
12.65 CCL2 IL18 IL1B IL6 TNF
17 12.6 CCL2 CCL5 IL1B IL3 TNF
18
Show member pathways
12.45 IL1A IL1B IL6 TNF
19
Show member pathways
12.45 CCL2 CCL5 CSF1 IL1B IL6 TNF
20
Show member pathways
12.44 CCL2 CCL7 CXCL2 IL1B IL6 TNF
21 12.33 IL18 IL1A IL1B IL6 TNF
22
Show member pathways
12.32 IL1A IL1B IL6 TNF
23
Show member pathways
12.29 IL18 IL1A IL1B IL3 IL6 TNF
24 12.24 IL1A IL1B IL6 TNF
25 12.16 CCL2 IL1A IL1B TNF
26
Show member pathways
12.13 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
27 12.12 CSF1 IL1A IL1B TNF
28 12.11 CCL2 CXCL2 IL1A IL1B IL6 TNF
29 12.11 CCL2 IL18 IL1A IL1B IL6 LIF
30 12.08 CSF1 IL3 IL6 TNF
31 12.07 CCL3 IL1A IL1B IL3 IL6
32 12.07 CCL2 CCL5 CSF1 CXCL2 IL1B IL6
33
Show member pathways
12.06 CCL3 CCL4 IL18 IL1B
34 12.04 IL3 IL6 LIF
35 12.04 IL6 LIF TNF
36 12.04 CCL2 IL1A IL1B IL6 TNF
37
Show member pathways
12.03 IL18 IL1B IL6 TNF
38 12.01 CSF1 IL1A IL1B IL3 IL6 TNF
39 11.97 CCL4 CXCL2 IL1B TNF
40 11.97 CCL3 CCL4 CXCL2 IL18 IL1A IL1B
41 11.89 IL1B IL6 TNF
42 11.89 CCL3 IL18 IL1B TNF
43 11.87 CSF1 IL1B IL6 TNF
44 11.86 IL1A IL1B IL6 TNF
45
Show member pathways
11.81 CXCL2 IL1A IL1B IL6 TNF
46 11.76 CCL2 CCL3 CCL5 CSF1 IL18 IL1A
47 11.74 CXCL2 IL18 IL1B IL6 TNF
48 11.73 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
49 11.68 CCL2 IL18 IL1B IL6 TNF
50 11.66 CSF1 IL1A IL1B IL3 IL6

GO Terms for Stachybotrys Chartarum

Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
2 extracellular space GO:0005615 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.99 CCL2 CXCL2 IL1B IL6
2 cellular response to tumor necrosis factor GO:0071356 9.99 CCL2 CCL3 CCL4 CCL5 CCL7 IL6
3 positive regulation of cell migration GO:0030335 9.98 CCL3 CCL5 CCL7 CSF1
4 regulation of cell shape GO:0008360 9.96 CCL2 CCL3 CCL7 IL6
5 cellular response to interferon-gamma GO:0071346 9.96 CCL2 CCL3 CCL4 CCL5 CCL7
6 cellular calcium ion homeostasis GO:0006874 9.94 CCL2 CCL3 CCL5 CCL7
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.93 CCL2 IL6 TNF
9 positive regulation of protein kinase B signaling GO:0051897 9.93 CCL3 IL18 IL6 TNF
10 response to virus GO:0009615 9.92 CCL4 CCL5 TNF
11 cell chemotaxis GO:0060326 9.92 CCL2 CCL3 CCL5 CXCL2
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 CCL5 IL18 IL3 IL6 LIF
13 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.91 IL1B IL6 TNF
14 response to toxic substance GO:0009636 9.91 CCL3 CCL4 CCL5
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 CCL5 IL18 IL6 TNF
16 cellular response to interleukin-1 GO:0071347 9.91 CCL2 CCL3 CCL4 CCL5 CCL7 IL6
17 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 IL3 IL6 LIF
18 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 IL6 LIF TNF
19 response to glucocorticoid GO:0051384 9.89 CCL2 IL6 TNF
20 protein kinase B signaling GO:0043491 9.89 CCL2 CCL3 CCL5 IL1B TNF
21 regulation of insulin secretion GO:0050796 9.88 CCL5 IL1B TNF
22 positive regulation of T cell proliferation GO:0042102 9.88 CCL5 IL1B IL6
23 positive regulation of interleukin-6 production GO:0032755 9.88 IL1A IL1B IL6 TNF
24 cellular response to organic cyclic compound GO:0071407 9.88 CCL2 CCL3 CCL5 IL18 IL1B TNF
25 humoral immune response GO:0006959 9.87 CCL2 IL6 TNF
26 positive regulation of cell adhesion GO:0045785 9.86 CCL2 CCL5 TNF
27 positive regulation of interferon-gamma production GO:0032729 9.85 IL18 IL1B TNF
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IL1B IL6 TNF
29 chemokine-mediated signaling pathway GO:0070098 9.85 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
30 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.84 IL1A IL1B TNF
31 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.83 IL18 IL6 LIF
32 positive regulation of calcium ion transport GO:0051928 9.82 CCL3 CCL4 CCL5
33 positive regulation of NF-kappaB import into nucleus GO:0042346 9.81 IL18 IL1B TNF
34 positive regulation of macrophage chemotaxis GO:0010759 9.8 CCL2 CCL5 CSF1
35 neutrophil chemotaxis GO:0030593 9.8 CCL2 CCL3 CCL4 CCL5 CCL7 IL1B
36 macrophage chemotaxis GO:0048246 9.79 CCL2 CCL3 CCL5
37 negative regulation by host of viral transcription GO:0043922 9.79 CCL3 CCL4 CCL5
38 eosinophil chemotaxis GO:0048245 9.77 CCL3 CCL5 CCL7
39 immune response GO:0006955 9.77 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
40 positive regulation of natural killer cell chemotaxis GO:2000503 9.76 CCL3 CCL4 CCL5 CCL7
41 positive regulation of JAK-STAT cascade GO:0046427 9.75 CCL5 IL6
42 positive regulation of calcium-mediated signaling GO:0050850 9.75 CCL3 CCL4
43 positive regulation of monocyte chemotaxis GO:0090026 9.75 CCL2 CCL5
44 negative regulation of lipid catabolic process GO:0050995 9.75 IL1B TNF
45 positive regulation of calcium ion import GO:0090280 9.75 CCL2 CCL3
46 positive regulation of chemokine production GO:0032722 9.75 IL6 TNF
47 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IL1B TNF
48 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.74 CSF1 IL18
49 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 IL1B TNF
50 positive regulation of macrophage differentiation GO:0045651 9.74 CSF1 LIF

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.67 CSF1 IL3 IL6 LIF
2 interleukin-1 receptor binding GO:0005149 9.5 IL1A IL1B IL3
3 cytokine activity GO:0005125 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
4 CCR1 chemokine receptor binding GO:0031726 9.46 CCL3 CCL4 CCL5 CCL7
5 CCR5 chemokine receptor binding GO:0031730 9.43 CCL3 CCL4 CCL5
6 chemokine activity GO:0008009 9.43 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
7 phospholipase activator activity GO:0016004 9.4 CCL3 CCL5

Sources for Stachybotrys Chartarum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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