MCID: STC004
MIFTS: 32

Stachybotrys Chartarum malady

Summaries for Stachybotrys Chartarum

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63Wikipedia, 32MalaCards
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Wikipedia:63 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards: Stachybotrys Chartarum, also known as stachybotrys atra, is related to rhinitis and allergic asthma. An important gene associated with Stachybotrys Chartarum is CCL7 (chemokine (C-C motif) ligand 7), and among its related pathways are Rheumatoid arthritis and Cytokines and Inflammatory Response. The compounds gm-csf and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Aliases & Classifications for Stachybotrys Chartarum

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42NIH Rare Diseases
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Aliases & Descriptions:

stachybotrys chartarum 42
stachybotrys atra 42


Related Diseases for Stachybotrys Chartarum

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Clinical Features for Stachybotrys Chartarum

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Drugs & Therapeutics for Stachybotrys Chartarum

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Stachybotrys Chartarum

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Anatomical Context for Stachybotrys Chartarum

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Animal Models for Stachybotrys Chartarum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Stachybotrys Chartarum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5CSF1, LIF, IL3, IL18, IL1A, IL1B
2MP:00053977.4CCL3, CCL7, CSF1, LIF, IL3, IL18
3MP:00053877.1IL1B, CCL3, CCL7, CSF1, LIF, IL3

Publications for Stachybotrys Chartarum

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Genetic Variations for Stachybotrys Chartarum

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Expression for genes affiliated with Stachybotrys Chartarum

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stachybotrys Chartarum

Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 52R&D Systems, 12EMD Millipore
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Pathways related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL18
29.9CXCL2
39.6IL1B, IL18
4
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9.5IL1A, IL1B
5
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9.4CCL7, CCL4
69.2CSF1, IL18, IL1B
79.2IL18, IL1A, IL1B
89.2IL18, IL1A, IL1B
9
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9.2IL1B, IL1A, IL18
109.1CCL3, CCL4
119.1IL1B, IL1A, CSF1
12
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9.1IL1B, IL1A, IL3
13
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9.1IL1B, IL1A, IL3
149.1IL1B, CSF1, CCL3
159.0IL1B, IL18, CXCL2
16
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9.0IL1B, IL18, CXCL2
178.9CXCL2, IL1A, IL1B
188.8CCL4, IL18, IL1B
19
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8.7IL1B, IL1A, IL18, IL3
20
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8.7IL3, IL18, IL1A, IL1B
218.7IL1B, IL1A, IL18, IL3
22
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8.7IL1B, IL1A, IL18, IL3
238.7CSF1, IL3, IL1A, IL1B
248.6CSF1, LIF, CXCL2, IL1B
25
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8.6IL1B, CCL3, CCL4
268.5IL1B, CXCL2, CCL4
27
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8.3IL1B, IL18, CCL3, CCL4
288.2CCL4, CCL3, CCL7, CXCL2
29
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8.2CCL4, CCL3, CCL7, CXCL2
30
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8.2CCL4, CCL3, CCL7, CXCL2
31
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8.2CXCL2, CCL7, CCL3, CCL4
32
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8.0CCL3, CCL7, CSF1, LIF, CXCL2, IL18
337.2CCL4, CCL3, CXCL2, IL18, IL1A, IL1B
34
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7.1IL3, CXCL2, LIF, CSF1, CCL7, CCL3
35
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5.8IL1B, IL1A, IL18, IL3, CXCL2, LIF
36
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5.8CCL3, CCL4, CCL7, CSF1, IL1B, IL1A

Compounds for genes affiliated with Stachybotrys Chartarum

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44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.6LIF
2cycloheximide4410.6IL18
3hydrocortisone44 2 59 1113.5LIF
4indomethacin44 59 28 1113.5CSF1
5pge24410.3CXCL2
6endotoxin4410.0CXCL2, LIF
7anaphylatoxin449.6CCL7, IL3, IL1B
8cyclosporin a44 28 5911.5CCL3, IL3, LIF
9dexamethasone44 49 28 1112.3CCL7, LIF, CXCL2, IL3
10creatinine449.0CCL4, CSF1, IL1A
11poly(i-c)448.9CCL3, IL3, IL1B, IL18
12methylcellulose448.8CSF1, LIF, IL1A, IL3, CCL3
13larc448.7CCL4, CCL7, CCL3, IL1A
14tgf beta1448.7CSF1, CCL3, LIF, IL1B, IL18
15polyinosinic-polycytidylic acid448.7CSF1, IL18, IL1A, IL1B, CCL3
16pdtc448.6IL18, IL1B, CCL3, IL1A
175fluorouracil448.6LIF, CCL3, IL18, IL3, CSF1
18calcitriol44 59 11 2411.6LIF, IL3, IL1B, IL1A, CSF1
19h2o2448.6IL3, CXCL2, IL18, CCL3, LIF
20mip 1alpha448.6IL3, IL1B, CCL3, CCL4
21teck448.5CCL4, CCL3, CCL7
22ribonucleic acid448.4CCL3, CCL7, LIF, IL1A, IL1B
23genistein44 28 59 2 11 2413.4IL1A, CCL7, CSF1, LIF, IL1B, IL3
24ccl444 289.4CCL3, CCL4, CXCL2, CCL7
25leukotriene b444 59 2410.3IL1B, IL1A, IL3, CSF1, CCL7, CCL3
2612-o-tetradecanoylphorbol 13-acetate448.3CSF1, IL1A, IL3, LIF, CXCL2
27ivig448.3IL1B, IL1A, IL3, CSF1, CCL4
28neopterin448.3IL18, CCL3, CSF1, IL3, IL1A, IL1B
29heparin44 28 11 2411.2CCL4, CCL3, CSF1, IL1A, LIF
30lactate448.1CCL3, CXCL2, IL3, IL18, CSF1, LIF
31n acetylcysteine448.1CSF1, CXCL2, IL3, IL18, IL1B
32ly294002448.0CCL3, IL1B, IL18, CXCL2, IL3, CSF1
33fmlp448.0IL3, IL1A, CCL3, CSF1, CCL7, IL1B
34actinomycin d448.0LIF, CSF1, IL3, CCL7, IL1B, IL1A
35ionomycin447.9CCL4, IL18, IL3, IL1A, CCL3, CSF1
36thymidine44 248.9IL18, IL3, LIF, CSF1, IL1B, CCL3
37tarc447.8CCL3, CCL4, IL18, CCL7, CXCL2, IL1A
38prostaglandin447.7CSF1, CCL4, LIF, CXCL2, IL1A, IL1B
39wortmannin447.7LIF, CXCL2, IL3, CCL4, CSF1, CCL3
40histamine44 28 249.6IL1B, IL18, IL3, CSF1, CCL3, CCL4
41serine447.4IL1A, LIF, CCL3, CCL4, CXCL2, CSF1
42ccl344 288.3IL1A, IL1B, IL18, CXCL2, CCL7, CCL3
43groalpha447.3IL1B, IL1A, IL18, CXCL2, CCL7, CCL3
44sb 20358044 598.3CCL3, IL18, CCL4, LIF, CXCL2, IL1A
45nitric oxide44 11 249.1IL1B, CXCL2, IL18, LIF, CCL4, CCL3
46il 10447.1IL3, LIF, CSF1, CCL3, CCL4, IL1B
47retinoic acid44 248.1IL1B, IL18, CSF1, CCL4, IL3, IL1A
48pd 98,059447.0IL3, IL18, CCL3, CCL4, IL1B, CSF1
49vegf446.9IL1B, IL1A, LIF, CSF1, CCL3, CCL4
50rantes446.6CXCL2, IL3, IL1A, IL1B, LIF, CSF1

GO Terms for genes affiliated with Stachybotrys Chartarum

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16Gene Ontology
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Cellular components related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.5CCL3, CCL7, CXCL2, IL3, IL18, IL1A
2extracellular spaceGO:0056155.5IL1B, CCL4, CCL3, CCL7, CSF1, LIF

Biological processes related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage differentiationGO:04565110.1CSF1, LIF
2eosinophil chemotaxisGO:04824510.0CCL7, CCL3
3positive regulation of granulocyte macrophage colony-stimulating factor productionGO:0327259.9IL1B, IL18
4monocyte chemotaxisGO:0025489.9CCL7, CCL3
5fever generationGO:0016609.8IL1B, IL1A
6positive regulation of NF-kappaB import into nucleusGO:0423469.8IL18, IL1B
7positive regulation of interleukin-2 biosynthetic processGO:0450869.8IL1B, IL1A
8positive regulation of interleukin-8 productionGO:0327579.8IL1B, IL18
9positive regulation vascular endothelial growth factor productionGO:0105759.7IL1A, IL1B
10cellular response to interferon-gammaGO:0713469.7CCL3, IL18
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, IL1A
12positive regulation of tumor necrosis factor productionGO:0327609.6IL18, CCL3
13positive regulation of cell migrationGO:0303359.6CSF1, CCL7, CCL3
14positive regulation of gene expressionGO:0106289.5CCL3, CSF1, IL18
15lipopolysaccharide-mediated signaling pathwayGO:0316639.4IL1B, IL18, CCL3
16cellular response to organic cyclic compoundGO:0714079.4CCL3, IL18, IL1B
17MAPK cascadeGO:0001659.4CCL3, IL18, IL1B
18negative regulation by host of viral transcriptionGO:0439229.4CCL4, CCL3
19positive regulation of mitosisGO:0458409.4IL1B, IL1A
20positive regulation of calcium-mediated signalingGO:0508509.4CCL4, CCL3
21positive regulation of natural killer cell chemotaxisGO:20005039.2CCL7, CCL3, CCL4
22positive regulation of calcium ion transportGO:0519289.1CCL3, CCL4
23protein kinase B signaling cascadeGO:0434919.1IL1B, CCL3
24chemotaxisGO:0069358.6CCL4, CCL3, CCL7, CXCL2
25cell-cell signalingGO:0072677.9CCL4, CCL3, CCL7, IL3, IL18, IL1B
26immune responseGO:0069557.0CCL4, CCL7, LIF, CXCL2, IL3, IL18
27inflammatory responseGO:0069546.9IL1B, CCL4, CCL3, CCL7, CSF1, CXCL2

Molecular functions related to Stachybotrys Chartarum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.4IL3, LIF, CSF1
2interleukin-1 receptor bindingGO:0051499.2IL1B, IL1A
3CCR5 chemokine receptor bindingGO:0317309.0CCL3, CCL4
4CCR1 chemokine receptor bindingGO:0317268.9CCL7, CCL3, CCL4
5chemokine activityGO:0080098.2CCL4, CCL3, CCL7, CXCL2
6cytokine activityGO:0051257.3IL1B, CCL4, CSF1, LIF, IL3, IL18

Products for genes affiliated with Stachybotrys Chartarum

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Sources for Stachybotrys Chartarum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet