MCID: STC004
MIFTS: 37

Stachybotrys Chartarum malady

Category: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

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Aliases & Descriptions for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 48
 
Stachybotrys Atra 48

Classifications:



Summaries for Stachybotrys Chartarum

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Wikipedia:71 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards based summary: Stachybotrys Chartarum, also known as stachybotrys atra, is related to childhood malignant mesenchymoma and allergic bronchopulmonary aspergillosis. An important gene associated with Stachybotrys Chartarum is IL18 (Interleukin 18), and among its related pathways are Hypertrophy Model and Overview of nanoparticle effects. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are cardiovascular system and integument.

Related Diseases for Stachybotrys Chartarum

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Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1childhood malignant mesenchymoma10.2CCL5, IL3, IL6
2allergic bronchopulmonary aspergillosis10.2CCL2, IL18, IL6
3dyslexia 510.2IL6, TNF
4drug dependence10.2IL6, LIF, TNF
5oculomotor nerve paralysis10.2IL1B, IL6
6orthostatic proteinuria10.2IL18, IL6, TNF
7common peroneal nerve lesion10.2IL1B, IL6
8red cell phospholipid defect with hemolysis10.2IL18, IL6, TNF
9hemosiderosis10.2
10neuronitis10.2
11leydig cell hypoplasia10.2IL18, IL6, TNF
12toxic optic neuropathy10.2IL1A, IL1B
13laryngotracheoesophageal cleft type 210.2IL18, IL1B, IL6
14intussusception10.2IL1B, TNF
15aortic atherosclerosis10.2IL6, TNF
16swine influenza10.2IL1A, IL6, TNF
17gastric leiomyoma10.2IL18, IL1B, IL6
18degenerative disc disease10.2IL6, TNF
19primary ciliary dyskinesia10.2IL1A, IL6, TNF
20vps11-related autosomal recessive hypomyelinating leukodystrophy10.2CCL5, IL6, TNF
21mixed mineral dust pneumoconiosis10.1CCL2, CCL5, IL6
22stiff-person syndrome10.1CCL2, CCL5, IL6
23erb-duchenne and dejerine-klumpke palsies10.1CCL5, IL6, TNF
24glucose intolerance10.1CCL2, IL18, TNF
25stickler syndrome, type v10.1IL1A, IL1B, IL6
26mansonelliasis10.1CCL5, IL6, TNF
27oppositional defiant disorder10.1CCL2, IL6, TNF
28amelogenesis imperfecta10.1CCL2, IL6, TNF
29early yaws10.1CCL5, IL1B, IL6
30tau syndrome10.1IL18, IL1B, TNF
31neovascular glaucoma10.1CCL2, IL6, TNF
32bipolar i disorder10.1IL1B, IL6, TNF
33mental retardation hypotonia skin hyperpigmentation10.1CCL5, IL1A, IL1B
34human immunodeficiency virus infectious disease10.1IL1B, IL6, TNF
35tinea capitis10.1IL1B, IL6, TNF
36measles10.1IL1B, IL6, TNF
37dextrocardia10.1IL1B, IL6, TNF
38hypoparathyroidism-retardation-dysmorphism syndrome10.1IL1B, IL6, TNF
39rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies10.1IL1B, IL6, TNF
40stocco dos santos syndrome10.1IL1B, TNF
41gonococcal endophthalmia10.1IL1B, IL6, TNF
42ectodermal dysplasia bartalos type10.1IL1B, IL6, TNF
43migraine with aura10.1IL1B, IL6, TNF
44neuropathy10.1IL1B, IL6, TNF
45hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.1CCL2, IL6, TNF
46splenic artery aneurysm10.1IL1B, IL6, TNF
47constant exophthalmos10.1CCL4, CCL5
48labyrinthitis10.1IL1B, IL6, TNF
49pancreas lymphoma10.1IL1B, IL6, TNF
50blepharochalasis10.1IL1B, IL6, TNF

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Symptoms & Phenotypes for Stachybotrys Chartarum

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MGI Mouse Phenotypes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CSF1, CXCL2, IL18, IL1A, IL1B, IL6
2MP:00107718.1CSF1, IL18, IL1A, IL1B, IL6, LIF
3MP:00053878.0CCL2, CCL5, CSF1, IL18, IL1A, IL1B

Drugs & Therapeutics for Stachybotrys Chartarum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

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Anatomical Context for Stachybotrys Chartarum

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MalaCards organs/tissues related to Stachybotrys Chartarum:

36
Lung, Testes, Monocytes, Brain, Colon

Publications for Stachybotrys Chartarum

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Articles related to Stachybotrys Chartarum:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. (27476483)
2016
2
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. (27148627)
2016
3
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. (27997578)
2016
4
Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. (27097835)
2016
5
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. (26036596)
2015
6
Genome Sequence of Stachybotrys chartarum Strain 51-11. (26430036)
2015
7
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. (24387683)
2014
8
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. (25346283)
2014
9
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. (23180821)
2013
10
Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. (21384497)
2013
11
Microbial volatile organic compound emissions from Stachybotrys chartarum growing on gypsum wallboard and ceiling tile. (24308451)
2013
12
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. (24139181)
2013
13
Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus Stachybotrys chartarum MXH-X73. (24308675)
2013
14
Allergen of the month--Stachybotrys chartarum. (22626607)
2012
15
Recurrence of Stachybotrys chartarum during mycological and toxicological study of bioaerosols collected in a dairy cattle shed. (22462447)
2012
16
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. (22552393)
2012
17
The influence of water activity and temperature on germination, growth and sporulation of Stachybotrys chartarum strains. (21347692)
2011
18
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. (21505873)
2011
19
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. (21982832)
2011
20
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. (21505872)
2011
21
Characterization of human antigenic proteins SchS21 and SchS34 from Stachybotrys chartarum. (21109751)
2011
22
Pulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicity. (20385656)
2010
23
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. (20150440)
2010
24
The relative allergenicity of Stachybotrys chartarum compared to house dust mite extracts in a mouse model. (20235799)
2010
25
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. (19796210)
2010
26
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. (20077192)
2009
27
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. (19459771)
2009
28
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. (20061240)
2009
29
Immunohistochemical and immunocytochemical detection of SchS34 antigen in Stachybotrys chartarum spores and spore impacted mouse lungs. (18046622)
2008
30
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. (18007011)
2008
31
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. (18460072)
2008
32
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. (18041646)
2008
33
Detection of Stachybotrys chartarum using rRNA, tri5, and beta-tubulin primers and determining their relative copy number by real-time PCR. (18499423)
2008
34
Characterization of monoclonal antibodies to an antigenic protein from Stachybotrys chartarum and its measurement in house dust. (18242638)
2008
35
DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins. (17534970)
2007
36
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. (17186382)
2007
37
Testing antimicrobial cleaner efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. (18062486)
2007
38
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. (17420079)
2007
39
The role of fungal proteinases in pathophysiology of Stachybotrys chartarum. (17610048)
2007
40
Comparison of four different methods for extraction of Stachybotrys chartarum spore DNA and verification by real-time PCR. (17499865)
2007
41
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. (17267247)
2007
42
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). (17764432)
2007
43
An in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells. (17411351)
2007
44
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. (16754538)
2006
45
DNA damage, redox changes, and associated stress-inducible signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. (16476459)
2006
46
Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice. (16322647)
2006
47
Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. (16882529)
2006
48
Solvent comparison in the isolation, solubilization, and toxicity of Stachybotrys chartarum spore trichothecene mycotoxins in an established in vitro luminescence protein translation inhibition assay. (16497399)
2006
49
Strain differences influence murine pulmonary responses to Stachybotrys chartarum. (16690987)
2006
50
Co-cultivation of Streptomyces californicus and Stachybotrys chartarum stimulates the production of cytostatic compound(s) with immunotoxic properties. (17095029)
2006

Variations for Stachybotrys Chartarum

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Expression for genes affiliated with Stachybotrys Chartarum

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Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

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Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL18, IL1A
29.8IL6, TNF
39.7IL1B, IL6
49.7IL3, IL6, LIF
59.6CSF1, IL3, IL6
69.5CCL2, IL6, LIF
79.5IL6, LIF, TNF
89.4IL18, IL1A, IL1B
99.3CCL2, IL18, IL1B
109.3IL18, IL1B, TNF
119.2IL1B, IL6, TNF
129.2IL1B, IL6, TNF
139.1CSF1, IL3, IL6, TNF
149.0CCL5, IL1A, IL1B, IL6
159.0IL18, IL1B, IL6, TNF
16
Show member pathways
9.0IL18, IL1B, IL6, TNF
179.0IL18, IL1B, IL6, TNF
188.9IL1A, IL1B, IL6, TNF
19
Show member pathways
8.9IL1A, IL1B, IL6, TNF
208.9IL1A, IL1B, IL6, TNF
218.9IL1A, IL1B, IL6, TNF
22
Show member pathways
8.9IL1A, IL1B, IL6, TNF
238.9IL1A, IL1B, IL6, TNF
248.9CSF1, IL1B, IL6, TNF
258.8CSF1, IL1A, IL1B, TNF
268.8CCL2, IL1A, IL1B, TNF
278.8CSF1, IL1A, IL1B, IL3, IL6
288.7CCL3, IL18, IL1B, TNF
29
Show member pathways
8.7IL18, IL1A, IL1B, IL6, TNF
308.7IL18, IL1A, IL1B, IL6, TNF
31
Show member pathways
8.7CCL3, CCL4, TNF
32
Show member pathways
8.6IL1A, IL1B, IL3, IL6, TNF
33
Show member pathways
8.6IL1A, IL1B, IL3, IL6, TNF
348.6CCL2, IL18, IL1B, IL6, TNF
35
Show member pathways
8.6CCL2, IL18, IL1B, IL6, TNF
368.6CCL3, IL1A, IL1B, IL3, IL6
378.5CCL2, IL1A, IL1B, IL6, TNF
388.5CCL2, CSF1, IL18, IL1B, TNF
398.4CCL2, CCL5, IL1B, IL3, TNF
40
Show member pathways
8.4IL18, IL1A, IL1B, IL3, IL6, TNF
418.4CXCL2, IL18, IL1B, IL6, TNF
42
Show member pathways
8.4CCL3, CCL4, IL18, IL1B
43
Show member pathways
8.3CXCL2, IL1A, IL1B, IL6, TNF
448.3CSF1, IL1A, IL1B, IL3, IL6, TNF
458.2CCL2, CCL3, CSF1, IL1B, TNF
46
Show member pathways
8.1CCL2, CCL5, CSF1, IL1B, IL6, TNF
478.1CCL4, CXCL2, IL1B, TNF
488.0CCL2, IL18, IL1A, IL1B, IL6, LIF
49
Show member pathways
7.9CCL2, CCL7, CXCL2, IL1B, IL6, TNF
50
Show member pathways
7.9CCL2, CCL5, IL18, IL1A, IL1B, IL6

GO Terms for genes affiliated with Stachybotrys Chartarum

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Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055765.5CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
2extracellular spaceGO:00056154.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hormone secretionGO:004688810.7IL6, LIF
2positive regulation of T-helper 2 cell differentiationGO:004563010.7IL18, IL6
3positive regulation of macrophage derived foam cell differentiationGO:001074410.6CSF1, IL18
4positive regulation of macrophage differentiationGO:004565110.6CSF1, LIF
5positive regulation of JAK-STAT cascadeGO:004642710.6CCL5, IL6
6epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
7negative regulation of lipid storageGO:001088810.5IL6, TNF
8positive regulation of chemokine productionGO:003272210.5IL6, TNF
9positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.5IL18, IL1B
10regulation of vascular endothelial growth factor productionGO:001057410.5CCL2, IL6
11positive regulation of monocyte chemotaxisGO:009002610.4CCL2, CCL5
12ectopic germ cell programmed cell deathGO:003523410.4IL1A, IL1B
13fever generationGO:000166010.4IL1A, IL1B
14positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.4IL3, IL6, LIF
15positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.4IL18, IL6, LIF
16positive regulation of interleukin-2 biosynthetic processGO:004508610.4IL1A, IL1B
17positive regulation of monocyte chemotactic protein-1 productionGO:007163910.4IL1A, IL1B
18astrocyte cell migrationGO:004361510.4CCL2, CCL3
19positive regulation of calcium ion importGO:009028010.3CCL2, CCL3
20negative regulation of lipid catabolic processGO:005099510.3IL1B, TNF
21positive regulation of calcidiol 1-monooxygenase activityGO:006055910.3IL1B, TNF
22positive regulation of chemokine biosynthetic processGO:004508010.3IL1B, TNF
23positive regulation of fever generationGO:003162210.3IL1B, TNF
24positive regulation of heterotypic cell-cell adhesionGO:003411610.3IL1B, TNF
25positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IL1B, TNF
26positive regulation of peptidyl-serine phosphorylationGO:003313810.2IL6, LIF, TNF
27cellular response to lipopolysaccharideGO:007122210.2CCL2, IL6, TNF
28regulation of establishment of endothelial barrierGO:190314010.2IL1B, TNF
29regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.2IL1B, TNF
30humoral immune responseGO:000695910.2CCL2, IL6, TNF
31positive regulation of macrophage chemotaxisGO:001075910.1CCL2, CCL5, CSF1
32eosinophil chemotaxisGO:004824510.1CCL3, CCL5, CCL7
33positive regulation of T cell proliferationGO:004210210.1CCL5, IL1B, IL6
34positive regulation of cell adhesionGO:004578510.0CCL2, CCL5, TNF
35positive regulation of interferon-gamma productionGO:003272910.0IL18, IL1B, TNF
36positive regulation of NF-kappaB import into nucleusGO:004234610.0IL18, IL1B, TNF
37response to glucocorticoidGO:005138410.0CCL2, IL6, TNF
38positive regulation of NF-kappaB transcription factor activityGO:005109210.0IL1B, IL6, TNF
39positive regulation of nitric oxide biosynthetic processGO:004542910.0IL1B, IL6, TNF
40positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.0IL1B, IL6, TNF
41negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1A, IL1B, TNF
42macrophage chemotaxisGO:004824610.0CCL2, CCL3, CCL5
43positive regulation of calcium-mediated signalingGO:00508509.9CCL3, CCL4
44positive regulation of smooth muscle cell proliferationGO:00486619.9CCL5, IL18, IL6, TNF
45regulation of insulin secretionGO:00507969.8CCL5, IL1B, TNF
46positive regulation of protein kinase B signalingGO:00518979.7CCL3, IL18, IL6, TNF
47positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.7CCL5, IL18, IL3, IL6, LIF
48positive regulation of cell migrationGO:00303359.7CCL3, CCL5, CCL7, CSF1
49positive regulation of interleukin-6 productionGO:00327559.7IL1A, IL1B, IL6, TNF
50cellular calcium ion homeostasisGO:00068749.7CCL2, CCL3, CCL5, CCL7

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.7CSF1, IL3, IL6, LIF
2phospholipase activator activityGO:00160049.6CCL3, CCL5
3interleukin-1 receptor bindingGO:00051499.5IL1A, IL1B, IL3
4CCR5 chemokine receptor bindingGO:00317309.4CCL3, CCL4, CCL5
5CCR1 chemokine receptor bindingGO:00317269.1CCL3, CCL4, CCL5, CCL7
6chemokine activityGO:00080098.1CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
7cytokine activityGO:00051255.3CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Sources for Stachybotrys Chartarum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet