MCID: STC004
MIFTS: 37

Stachybotrys Chartarum malady

Category: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

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Aliases & Descriptions for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 47
 
Stachybotrys Atra 47

Classifications:



Summaries for Stachybotrys Chartarum

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Wikipedia:70 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

MalaCards based summary: Stachybotrys Chartarum, also known as stachybotrys atra, is related to asthma and panner disease. An important gene associated with Stachybotrys Chartarum is IL18 (Interleukin 18), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Interleukin-1 processing. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are cardiovascular system and integument.

Related Diseases for Stachybotrys Chartarum

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Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1asthma28.0CCL3, CCL5, IL18, IL1A, IL1B, IL3
2panner disease10.5IL6, TNF
3aortic arch interruption10.4IL6, TNF
4anterior dislocation of lens10.4CSF1, IL6
5cutaneous leishmaniasis10.4IL6, TNF
6corneal deposit10.4IL1B, IL6
7maligant granulosa cell tumor of ovary10.4IL6, TNF
8tricho odonto onycho dermal syndrome10.4IL6, TNF
9tarsal tunnel syndrome10.4IL1B, IL6
10scrotum melanoma10.4CCL2, IL18, IL6
11diabetic cataract10.4IL1A, IL1B
12silo filler's disease10.4IL18, IL1B
13small intestine lymphoma10.4IL1A, TNF
14renal cell carcinoma 410.3IL18, IL6, TNF
15hemometra10.3IL6, LIF, TNF
16vertebral artery insufficiency10.3IL18, IL6, TNF
17leukoplakia10.3IL18, IL6, TNF
18neurogenic bowel10.3IL18, IL6, TNF
19vibrio vulnificus infection10.3CCL2, IL6
20vestibular nystagmus10.3IL18, IL6, TNF
21midline interhemispheric variant of holoprosencephaly10.3IL18, IL1B, IL6
22thyroid malformation10.3IL1B, TNF
23syphilitic encephalitis10.3IL18, IL1B, IL6
24epstein-barr virus hepatitis10.3IL1A, IL6, TNF
25abdominal chemodectomas with cutaneous angiolipomas10.3IL6, TNF
26benign mammary dysplasia10.3CCL2, CCL5, IL6
27primary biliary cirrhosis10.3IL1A, IL6, TNF
28hemoglobinopathy10.3IL1B, IL6
29hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.3IL1B, TNF
30mental retardation anophthalmia craniosynostosis10.3IL1A, IL1B
31melorheostosis10.2IL1B, IL6
32exophthalmos10.2CCL7, IL3, TNF
33hyperparathyroidism10.2CCL2, IL1B
34periodic paralyses10.2IL1A, IL1B, IL6
35antigen-peptide-transporter 2 deficiency10.2CCL2, IL6, TNF
36baetz-greenwalt syndrome10.2IL1B, TNF
37gastric ulcer10.2CCL5, IL6, TNF
38pulmonary hypertension10.2IL1B, TNF
39intervertebral disc disease10.2IL1A, IL1B, IL6
40geniculate herpes zoster10.2CCL5, IL6, TNF
41alopecia10.2CCL2, IL6, TNF
42renal tubular acidosis10.2CCL2, IL18, TNF
43hemosiderosis10.2
44neuronitis10.2
45kernicterus10.2CCL2, IL6, TNF
46isthmus cancer10.2IL1A, IL6, TNF
47short bowel syndrome10.1CCL2, IL6, TNF
48mixed lacrimal gland cancer10.1CCL2, IL6, TNF
49histoplasmosis pericarditis10.1CCL2, IL6, TNF
50infancy electroclinical syndrome10.1IL1B, IL6

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to stachybotrys chartarum

Symptoms for Stachybotrys Chartarum

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Drugs & Therapeutics for Stachybotrys Chartarum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

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Anatomical Context for Stachybotrys Chartarum

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MalaCards organs/tissues related to Stachybotrys Chartarum:

35
Lung, Testes, Monocytes, Brain, Colon

Animal Models for Stachybotrys Chartarum or affiliated genes

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MGI Mouse Phenotypes related to Stachybotrys Chartarum:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CSF1, CXCL2, IL18, IL1A, IL1B, IL6
2MP:00107718.1CSF1, IL18, IL1A, IL1B, IL6, LIF
3MP:00053878.0CCL2, CCL5, CSF1, IL18, IL1A, IL1B

Publications for Stachybotrys Chartarum

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Articles related to Stachybotrys Chartarum:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. (27148627)
2016
2
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. (27997578)
2016
3
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. (27476483)
2016
4
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. (24387683)
2014
5
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. (25346283)
2014
6
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. (23180821)
2013
7
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. (21505872)
2011
8
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. (20150440)
2010
9
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. (20077192)
2009
10
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. (19459771)
2009
11
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. (18041646)
2008
12
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. (18460072)
2008
13
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. (17267247)
2007
14
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. (17420079)
2007
15
Pulmonary cytotoxicity of secondary metabolites of Stachybotrys chartarum (Ehrenb.) Hughes. (17195998)
2006
16
The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity. (16436280)
2006
17
Comparison of inflammatory responses in mouse lungs exposed to atranones A and C from Stachybotrys chartarum. (16754538)
2006
18
Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum. (16882529)
2006
19
Interactions between Streptomyces californicus and Stachybotrys chartarum can induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages. (15667833)
2005
20
Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms. (15647601)
2005
21
Antibodies against Stachybotrys chartarum extract and its antigenic components, Stachyhemolysin and Stachyrase-A: a new clinical biomarker. (15874884)
2005
22
Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells. (15574675)
2005
23
The Pathogenicity of Stachybotrys chartarum. (15864257)
2005
24
Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins on particulates smaller than conidia. (15640178)
2005
25
Attributes of Stachybotrys chartarum and its association with human disease. (14767429)
2004
26
Protein translation inhibition by Stachybotrys chartarum conidia with and without the mycotoxin containing polysaccharide matrix. (15487326)
2004
27
Immunochemical Assay for Satratoxin G and other Macrocyclic Trichothecenes Associated with Indoor Air Contamination by Stachybotrys chartarum. (20021149)
2003
28
Molecular and phenotypic descriptions of Stachybotrys chlorohalonata sp. nov. and two chemotypes of Stachybotrys chartarum found in water-damaged buildings. (21149024)
2003
29
Histological, immunohistochemical and morphometric changes in lung tissue in juvenile mice experimentally exposed to Stachybotrys chartarum spores. (12733633)
2003
30
Stachybotrys chartarum (chartarum = atra = alternans) and other problems caused by allergenic fungi. (12635571)
2003
31
Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective. (12525430)
2003
32
Cryptic species in Stachybotrys chartarum. (21156555)
2002
33
IgE-reactive proteins from Stachybotrys chartarum. (12141716)
2002
34
An extract of Stachybotrys chartarum causes allergic asthma-like responses in a BALB/c mouse model. (12388839)
2002
35
Effects of aerosols from nontoxic Stachybotrys chartarum on murine airways. (12028806)
2002
36
A Stachybotrys chartarum isolate from soybean. (12041871)
2002
37
Preliminary description of antigenic components characteristic of Stachybotrys chartarum. (11237513)
2001
38
Analysis of pulmonary surfactant by Fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) spores. (11245829)
2001
39
Stachybotrys chartarum: current knowledge of its role in disease. (11104457)
2000
40
Atranones A-G, from the toxigenic mold Stachybotrys chartarum. (11130678)
2000
41
Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: quantitative assessment before, during, and after remediation. (10741843)
2000
42
Quantification of siderophore and hemolysin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis. (10831457)
2000
43
Volatile sesquiterpenes from Stachybotrys chartarum: Indicators for trichothecene producing mold species? (19009424)
2000
44
Sick building syndrome. III. Stachybotrys chartarum. (10805208)
2000
45
Sanitation of wallboard colonized with Stachybotrys chartarum. (10387112)
1999
46
Hemolysis, toxicity, and randomly amplified polymorphic DNA analysis of Stachybotrys chartarum strains. (10388719)
1999
47
Quantitative measurement of Stachybotrys chartarum conidia using real time detection of PCR products with the TaqMan(TM)fluorogenic probe system. (10508554)
1999
48
Stachybotrys chartarum (atra) contamination of the indoor environment: Health implications. (20212975)
1999
49
Identification of putative sequence specific PCR primers for detection of the toxigenic fungal species Stachybotrys chartarum. (9843656)
1998
50
Discovery of toxicogenic Stachybotrys chartarum strains in Finland. (5013039)
1972

Variations for Stachybotrys Chartarum

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Expression for genes affiliated with Stachybotrys Chartarum

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Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for genes affiliated with Stachybotrys Chartarum

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Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 48)
idSuper pathwaysScoreTop Affiliating Genes
19.5CCL2, IL6, LIF
29.4IL18, IL1A, IL1B
39.3IL18, IL1B, TNF
49.1CSF1, IL3, IL6, TNF
59.0CCL5, IL1A, IL1B, IL6
6
Show member pathways
9.0IL18, IL1B, IL6, TNF
79.0IL18, IL1B, IL6, TNF
8
Show member pathways
8.9IL1A, IL1B, IL6, TNF
98.9IL1A, IL1B, IL6, TNF
108.9IL1A, IL1B, IL6, TNF
118.9IL1A, IL1B, IL6, TNF
128.9IL1A, IL1B, IL6, TNF
138.9CSF1, IL1B, IL6, TNF
148.8CSF1, IL1A, IL1B, TNF
158.7CCL3, IL18, IL1B, TNF
168.7IL18, IL1A, IL1B, IL6, TNF
17
Show member pathways
8.7CCL3, CCL4, TNF
18
Show member pathways
8.6IL1A, IL1B, IL3, IL6, TNF
19
Show member pathways
8.6CCL2, IL18, IL1B, IL6, TNF
208.6CCL2, IL18, IL1B, IL6, TNF
218.6CCL3, IL1A, IL1B, IL3, IL6
228.5CCL2, IL1A, IL1B, IL6, TNF
238.5CCL2, CSF1, IL18, IL1B, TNF
248.4CCL2, CCL5, IL1B, IL3, TNF
25
Show member pathways
8.4IL18, IL1A, IL1B, IL3, IL6, TNF
26
Show member pathways
8.4IL18, IL1A, IL1B, IL3, IL6, TNF
278.4CXCL2, IL18, IL1B, IL6, TNF
28
Show member pathways
8.4CCL3, CCL4, IL18, IL1B
298.3CSF1, IL1A, IL1B, IL3, IL6, TNF
30
Show member pathways
8.3CCL4, CCL5, IL18, IL1B, IL6
318.2CCL2, CCL3, CSF1, IL1B, TNF
328.1CCL4, CXCL2, IL1B, TNF
338.0CSF1, CXCL2, IL1A, IL1B, IL6, TNF
34
Show member pathways
7.9CCL2, CCL5, IL18, IL1A, IL1B, IL6
357.9CCL2, CXCL2, IL1A, IL1B, IL6, TNF
36
Show member pathways
7.6CCL2, CCL5, CXCL2, IL18, IL1B, IL6
37
Show member pathways
7.4CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
387.2CCL2, CCL5, CSF1, CXCL2, IL1B, IL6
39
Show member pathways
7.2CCL3, CCL4, CXCL2, IL18, IL1A, IL1B
40
Show member pathways
7.1CCL2, CCL3, CCL4, CCL5, IL1B, IL6
417.0CCL2, CCL3, CCL5, CSF1, IL18, IL1A
42
Show member pathways
6.4CCL2, CCL3, CCL4, CCL5, CCL7, IL18
43
Show member pathways
6.0CCL2, CCL3, CCL4, CCL5, CCL7, IL18
444.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
45
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
46
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
47
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1
48
Show member pathways
4.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

GO Terms for genes affiliated with Stachybotrys Chartarum

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Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055764.8CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
2extracellular spaceGO:00056154.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1regulation of vascular endothelial growth factor productionGO:001057410.5CCL2, IL6
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.5IL6, TNF
3fever generationGO:000166010.4IL1A, IL1B
4positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.3IL18, IL6, LIF
5positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IL1B, TNF
6sequestering of triglycerideGO:003073010.2IL1B, TNF
7chronic inflammatory response to antigenic stimulusGO:000243910.2IL1B, TNF
8humoral immune responseGO:000695910.0CCL2, IL6, TNF
9positive regulation of macrophage chemotaxisGO:001075910.0CCL2, CCL5, CSF1
10eosinophil chemotaxisGO:004824510.0CCL3, CCL5, CCL7
11positive regulation of osteoclast differentiationGO:00456729.9CCL5, CSF1, TNF
12positive regulation of NF-kappaB import into nucleusGO:00423469.9IL18, IL1B, TNF
13positive regulation of interferon-gamma productionGO:00327299.9IL18, IL1B, TNF
14positive regulation of cell adhesionGO:00457859.8CCL2, CCL5, TNF
15macrophage chemotaxisGO:00482469.8CCL2, CCL3, CCL5
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1A, IL1B, TNF
17positive regulation of fever generationGO:00316229.7CCL5, IL1B, TNF
18response to gamma radiationGO:00103329.7CCL2, CCL7, IL1B
19lymphocyte chemotaxisGO:00482479.7CCL2, CCL3, CCL5
20positive regulation of nitric oxide biosynthetic processGO:00454299.7IL1B, IL6, TNF
21response to glucocorticoidGO:00513849.6CCL2, CCL5, IL6, TNF
22response to heatGO:00094089.4CCL2, IL1B, IL6
23negative regulation by host of viral transcriptionGO:00439229.4CCL3, CCL4, CCL5
24positive regulation of interleukin-6 productionGO:00327559.4IL1A, IL1B, IL6, TNF
25positive regulation of calcium ion transportGO:00519289.4CCL3, CCL4, CCL5
26regulation of cell shapeGO:00083609.4CCL2, CCL3, CCL7, IL6
27cytokine-mediated signaling pathwayGO:00192219.2CCL2, IL1A, IL1B, IL3, IL6
28agingGO:00075689.0CCL2, CCL5, IL1B, IL6
29positive regulation of natural killer cell chemotaxisGO:20005039.0CCL3, CCL4, CCL5, CCL7
30cellular calcium ion homeostasisGO:00068748.9CCL2, CCL3, CCL5, CCL7
31protein kinase B signalingGO:00434918.8CCL2, CCL3, CCL5, IL1B, TNF
32positive regulation of cell migrationGO:00303358.8CCL3, CCL5, CCL7, CSF1
33chemotaxisGO:00069358.6CCL2, CCL3, CCL5, CCL7, CXCL2
34lipopolysaccharide-mediated signaling pathwayGO:00316638.6CCL2, CCL3, CCL5, IL18, IL1B, TNF
35cellular response to interferon-gammaGO:00713468.6CCL2, CCL3, CCL4, CCL5, CCL7
36positive regulation of inflammatory responseGO:00507298.4CCL2, CCL3, CCL4, CCL5, CCL7, IL18
37cellular response to organic cyclic compoundGO:00714078.4CCL2, CCL3, CCL5, IL18, IL1B, TNF
38monocyte chemotaxisGO:00025488.4CCL2, CCL3, CCL4, CCL5, CCL7, IL6
39cellular response to interleukin-1GO:00713478.3CCL2, CCL3, CCL4, CCL5, CCL7, IL6
40cellular response to tumor necrosis factorGO:00713568.3CCL2, CCL3, CCL4, CCL5, CCL7, IL6
41immune responseGO:00069558.3CCL4, CXCL2, IL18, IL1A, IL3, LIF
42neutrophil chemotaxisGO:00305938.0CCL2, CCL3, CCL4, CCL5, CCL7, IL1B
43positive regulation of GTPase activityGO:00435478.0CCL2, CCL3, CCL4, CCL5, CCL7, IL3
44MAPK cascadeGO:00001658.0CCL2, CCL3, CCL5, IL18, IL1B, IL3
45chemokine-mediated signaling pathwayGO:00700987.9CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
46cell-cell signalingGO:00072677.8CCL3, CCL4, CCL5, CCL7, IL18, IL1B
47positive regulation of gene expressionGO:00106287.5CCL3, CSF1, IL18, IL1A, IL1B, IL6
48positive regulation of ERK1 and ERK2 cascadeGO:00703746.5CCL2, CCL3, CCL4, CCL5, CCL7, IL1B
49inflammatory responseGO:00069545.7CCL2, CCL3, CCL4, CCL5, CCL7, CSF1

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:003172710.2CCL2, CCL7
2interleukin-1 receptor bindingGO:000514910.2IL1A, IL1B
3phospholipase activator activityGO:001600410.1CCL3, CCL5
4growth factor activityGO:00080839.3CSF1, IL3, IL6, LIF
5CCR5 chemokine receptor bindingGO:00317309.2CCL3, CCL4, CCL5
6CCR1 chemokine receptor bindingGO:00317269.0CCL3, CCL4, CCL5, CCL7
7chemokine activityGO:00080097.3CCL2, CCL3, CCL4, CCL5, CCL7, CXCL2
8cytokine activityGO:00051256.3CCL2, CCL4, CSF1, IL18, IL1A, IL1B

Sources for Stachybotrys Chartarum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet