Stapes Ankylosis with Broad Thumb and Toes malady

MalaCards: Stapes Ankylosis with Broad Thumb and Toes, also known as stapes ankylosis with broad thumb and toes (disorder), is related to stapes ankylosis syndrome without symphalangism and ankylosis. An important gene associated with Stapes Ankylosis with Broad Thumb and Toes is NOG (noggin).

OMIM: 184460

stapes ankylosis with broad thumb and toes 16 33 stapes ankylosis with broad thumb and toes (disorder) 43

stapes ankylosis syndrome without symphalangism 16 teunissen-cremers syndrome 16

Diseases related to stapes ankylosis with broad thumb and toes by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	stapes ankylosis syndrome without symphalangism	9.7
2	ankylosis	9.4
3	hyperopia	9.4
4	nasodigitoacoustic syndrome	8.0

Clinical features from OMIM: 184460

Approved drugs:

Drug clinical trials:

Genetic tests related to stapes ankylosis with broad thumb and toes:

id	Genetic test	Affiliating Genes
1	Stapes Ankylosis With Broad Thumb And Toes clinical/research	NOG

Articles related to stapes ankylosis with broad thumb and toes:

id	Title	Authors	Year	Affiliating Genes
1	Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. (12089654)	Brown D.J.... Lesperance M.M.	2002	NOG

Genes related to stapes ankylosis with broad thumb and toes according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	NOG	noggin	11.1	Publications, Disorders