MCID: STP004
MIFTS: 42

Staphylococcal Toxic Shock Syndrome

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

MalaCards integrated aliases for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 50 69
Bacterial Toxic-Shock Syndrome 50 56
Staphylococcal Toxic-Shock Syndrome 56
Staphylococcal Tss 56
Bacterial Tss 56

Characteristics:

Orphanet epidemiological data:

56
bacterial toxic-shock syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
staphylococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 34 A48.3
UMLS via Orphanet 70 C3714602

Summaries for Staphylococcal Toxic Shock Syndrome

NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 36234disease definitionbacterial toxic shock syndrome (tss) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. tss is mediated by superantigenic toxins, usually caused by an infection with staphylococcus aureus in staphylococcal tss (see this term) or streptococcus pyogenes in streptococcal tss (see this term).epidemiologythe worldwide prevalence is estimated at 1/30, 000.clinical descriptionthe disease affects mainly young adult women with no previous medical conditions. however, non-menstrual tss, which can also be observed in men and children, represents up to 50% of staphylococcal tss cases. onset is sudden and includes high fever (>38.9°c), nausea, diarrhea, vomiting, myalgia, abdominal pain and sore throat. staphylococcal tss almost always exhibits an erythematous rash and skin peeling as one of its manifestations, whereas it is very rarely seen in streptococcal tss, which can show signs of soft tissue infection. serious manifestations include confusion, shock, renal and myocardial dysfunction, acute respiratory distress syndrome (ards; see this term) and coma.etiologystaphylococcal tss is due to an infection with staphylococcus aureus and streptococcal tss is due to an infection with streptococcus pyogenes, or rarely, group c or g streptococcus. superantigens produced by both bacteria are responsible for the massive and sudden immune reaction seen in tss. both forms have been associated with recent traumas (surgery or childbirth) and viral infections, while staphylococcal tss has also been associated with high absorbency tampon use.visit the orphanet disease page for more resources. last updated: 11/4/2015

MalaCards based summary : Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Amoxicillin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and colon.

Related Diseases for Staphylococcal Toxic Shock Syndrome

Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
id Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 10.7
2 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.5 CIITA TNF
3 anencephaly and spina bifida x-linked 10.5 HMGB1 TNF
4 macular dystrophy, atypical vitelliform 10.5 HMGB1 TNF
5 pericholangitis 10.4 HMGB1 TNF
6 autoimmune polyglandular syndrome type 3 10.4 IFNG TNF
7 mosaic trisomy 1 10.4 IFNG TNF
8 primary systemic mycosis 10.4 IFNG TNF
9 plantar wart 10.4 IFNG TNF
10 oropharyngeal cancer, childhood 10.4 IFNG TNF
11 lymphocytic colitis 10.4 IFNG TNF
12 pasteurellosis 10.4 IFNG TNF
13 parametritis 10.4 IFNG TNF
14 polyarteritis nodosa 10.3 IFNG TNF
15 sparse hair ptosis mental retardation 10.3 IFNG TNF
16 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.3 IFNG TNF
17 spindle cell hemangioma 10.3 IFNG TNF
18 atrichia with papular lesions 10.3 IFNG TNF
19 cyclosporiasis 10.3 IFNG TNF
20 tularemia 10.3 IFNG TNF
21 hepadnavirus infection 10.3 IFNG TNF
22 bolivian hemorrhagic fever 10.3 IFNG TNF
23 steatorrhea 10.3 IFNG TNF
24 psychologic dyspareunia 10.3 IFNG TNF
25 hemophagocytic lymphohistiocytosis 10.3 IFNG TNF
26 acute vascular insufficiency of intestine 10.3 IFNG TNF
27 dysphagia 10.3 IFNG TNF
28 conduct disorder 10.3 IFNG TNF
29 cutaneous fibrous histiocytoma 10.3 IFNG TNF
30 acute monoblastic leukemia 10.3 IFNG TNF
31 reardon wilson cavanagh syndrome 10.3 IFNG TNF
32 hypospadias 10.3 IFNG TNF
33 membranoproliferative glomerulonephritis 10.3 IFNG TNF
34 louping ill 10.3 IFNG TNF
35 orbital osteomyelitis 10.3 IFNG TNF
36 disease of mental health 10.3 IFNG TNF
37 motor peripheral neuropathy 10.3 IFNG TNF
38 abnormal retinal correspondence 10.3 IFNG TNF
39 x-linked intellectual disability, van esch type 10.3 IFNG IGHE
40 extrahepatic bile duct adenocarcinoma 10.3 IFNG TNF
41 hypercalcinuria macular coloboma 10.2 IFNG IGHE
42 melioidosis 10.2 IFNG TNF
43 herpangina 10.2 HMGB1 IFNG
44 cornea cancer 10.2 IFNG TNF
45 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.2 IFNG IGHE
46 esophagus melanoma 10.2 IFNG TNF
47 papillary squamous carcinoma 10.2 IFNG IGHE
48 dentinogenesis imperfecta 10.2 IFNG TNF
49 left bundle branch hemiblock 10.2 IFNG TNF
50 heart sarcoma 10.2 IFNG TNF

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to Staphylococcal Toxic Shock Syndrome

Symptoms & Phenotypes for Staphylococcal Toxic Shock Syndrome

Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

Drugs for Staphylococcal Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3
Rifampin Approved Phase 4 13292-46-1 5458213 5381226
4
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Antibodies Phase 4,Phase 2
8 gamma-Globulins Phase 4,Phase 2
9 Immunoglobulins Phase 4,Phase 2
10 Immunoglobulins, Intravenous Phase 4,Phase 2
11 Pharmaceutical Solutions Phase 4,Phase 2
12 Rho(D) Immune Globulin Phase 4,Phase 2
13 Amoxicillin-Potassium Clavulanate Combination Phase 4
14 Antibiotics, Antitubercular Phase 4
15 beta-Lactamase Inhibitors Phase 4
16 Clavulanic Acid Phase 4
17 Clindamycin palmitate Phase 4
18 Clindamycin phosphate Phase 4
19 proline Nutraceutical Phase 4
20 Vaccines Phase 2,Phase 1
21
Aluminum hydroxide Approved Phase 1 21645-51-2
22 Adjuvants, Immunologic Phase 1
23 Antacids Phase 1
24 Anti-Ulcer Agents Phase 1
25 Gastrointestinal Agents Phase 1
26 methicillin

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin
2 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Recruiting NCT02219165 Phase 2 Intravenous human immunoglobulin;Albumin
3 Clinical Trial of the BioMed rTSST‐1 Variant Vaccine in Healthy Adults Recruiting NCT02814708 Phase 2
4 Phase I STEBVax in Healthy Adults Completed NCT00974935 Phase 1 Aluminum hydroxide
5 Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial Completed NCT02971670 Phase 1
6 rTSST-1 Variant Vaccine Phase 1 First-in-man Trail Completed NCT02340338 Phase 1
7 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

Anatomical Context for Staphylococcal Toxic Shock Syndrome

MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

39
Skin, T Cells, Colon, Monocytes, B Cells, Testes

Publications for Staphylococcal Toxic Shock Syndrome

Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50) (show all 79)
id Title Authors Year
1
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. ( 27863161 )
2017
2
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28580155 )
2017
3
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28721224 )
2017
4
Acute encephalopathy with biphasic seizures and late reduced diffusion associated with staphylococcal toxic shock syndrome caused by burns. ( 27117386 )
2016
5
Staphylococcal toxic shock syndrome caused by tampon use. ( 25692047 )
2015
6
A fatal case of staphylococcal toxic shock syndrome. ( 26265799 )
2015
7
Unusual staphylococcal toxic shock syndrome presenting as a scarlet-like fever. ( 26543563 )
2015
8
Evidence of Staphylococcal Toxic Shock Syndrome caused by MRSA in a Mother-Newborn Pair. ( 25260039 )
2014
9
Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. ( 24816557 )
2014
10
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. ( 24423010 )
2014
11
Images in clinical medicine. Staphylococcal toxic shock syndrome. ( 23984732 )
2013
12
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. ( 22431984 )
2012
13
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. ( 21860665 )
2011
14
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. ( 21253349 )
2010
15
Staphylococcal toxic shock syndrome presenting as acute respiratory distress and cor pulmonale. ( 20196940 )
2010
16
Staphylococcal toxic shock syndrome: mechanisms and management. ( 21308522 )
2010
17
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. ( 20367234 )
2010
18
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. ( 19402965 )
2009
19
Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity. ( 19911998 )
2009
20
Staphylococcal toxic shock syndrome. ( 18697637 )
2008
21
Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vbeta signature in peripheral blood of a 12-year-old boy. ( 18277923 )
2008
22
Staphylococcal toxic shock syndrome toxin-1 induces the translocation and secretion of high mobility group-1 protein from both activated T cells and monocytes. ( 19009026 )
2008
23
Analysis of superantigenic toxin Vbeta T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. ( 18373692 )
2008
24
Symmetrical Peripheral Gangrene complicating Staphylococcal Toxic Shock Syndrome. ( 27408131 )
2008
25
A rare case of staphylococcal toxic shock syndrome after abdominoplasty. ( 19341642 )
2007
26
Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. ( 17409134 )
2007
27
Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics. ( 16447124 )
2006
28
Staphylococcal toxic shock syndrome: still a problem. ( 16116687 )
2005
29
Reemergence of staphylococcal toxic shock syndrome in the United States since 2000. ( 15815055 )
2005
30
Staphylococcal toxic shock syndrome: still a problem. ( 15963025 )
2005
31
Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. ( 15122526 )
2004
32
Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. ( 15184497 )
2004
33
Expansion of TcRalphabeta+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. ( 15034239 )
2004
34
A 37-year-old man with a febrile illness. Staphylococcal toxic shock syndrome. ( 17171845 )
2003
35
Staphylococcal toxic shock syndrome in a small infant. ( 11938403 )
2002
36
Bacteremic nonmenstrual staphylococcal toxic shock syndrome associated with enterotoxins A and C. ( 11170971 )
2001
37
Staphylococcal toxic shock syndrome. Suspicion and prevention are keys to control. ( 11675982 )
2001
38
Postoperative staphylococcal toxic shock syndrome due to pre-existing staphylococcal infection: case report and review of the literature. ( 11510574 )
2001
39
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. ( 10721486 )
2000
40
Interaction of staphylococcal toxic shock syndrome toxin-1 and enterotoxin A on T cell proliferation and TNFI+ secretion in human blood mononuclear cells. ( 22346398 )
1999
41
Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis. ( 10329825 )
1999
42
Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. ( 10405382 )
1999
43
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. ( 8643591 )
1996
44
Staphylococcal toxic shock syndrome associated with human immunodeficiency virus infection: report of a case with bacteremia. ( 8722964 )
1996
45
Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. ( 8821303 )
1995
46
Staphylococcal toxic shock syndrome in a paediatric burn unit. ( 7880413 )
1994
47
Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1. ( 8253961 )
1993
48
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. ( 1639516 )
1992
49
Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. ( 1612731 )
1992
50
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1. ( 2313089 )
1990

Variations for Staphylococcal Toxic Shock Syndrome

Expression for Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for Staphylococcal Toxic Shock Syndrome

Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CIITA HMGB1 IFNG IGHE IL1B TNF
2
Show member pathways
13.11 CIITA IFNG IGHE IL1B TNF
3
Show member pathways
12.98 HMGB1 IFNG IL1B TNF
4
Show member pathways
12.66 CIITA IFNG IL1B TNF
5
Show member pathways
12.59 CIITA IFNG IL1B TNF
6
Show member pathways
12.51 HMGB1 IFNG IL1B TNF
7
Show member pathways
12.47 IFNG IL1B TNF
8
Show member pathways
12.44 IFNG IGHE TNF
9
Show member pathways
12.4 IFNG IL1B TNF
10
Show member pathways
12.39 IFNG IL1B TNF
11 12.31 CIITA IFNG IL1B TNF
12
Show member pathways
12.25 IFNG IL1B TNF
13
Show member pathways
12.16 IFNG IL1B TNF
14
Show member pathways
12.11 IFNG IL1B TNF
15
Show member pathways
12.03 IFNG IL1B TNF
16
Show member pathways
12.01 IFNG IL1B TNF
17 11.95 IFNG IL1B TNF
18 11.89 IFNG IL1B TNF
19 11.85 IFNG IL1B TNF
20
Show member pathways
11.83 CIITA IFNG IL1B TNF
21 11.82 IGHE IL1B TNF
22
Show member pathways
11.78 IFNG IL1B TNF
23 11.72 IFNG IL1B TNF
24
Show member pathways
11.69 IFNG IL1B
25 11.68 IFNG IL1B TNF
26 11.62 IFNG IL1B TNF
27 11.58 IFNG IL1B TNF
28 11.51 IL1B TNF
29 11.51 CIITA IFNG IL1B TNF
30
Show member pathways
11.49 IFNG TNF
31 11.47 IFNG TNF
32
Show member pathways
11.47 IFNG IL1B TNF
33 11.44 IL1B TNF
34 11.41 IFNG TNF
35
Show member pathways
11.39 IFNG TNF
36 11.38 IL1B TNF
37 11.37 HMGB1 TNF
38 11.34 IFNG IL1B TNF
39
Show member pathways
11.31 IL1B TNF
40 11.31 IFNG IL1B TNF
41 11.29 IFNG IL1B TNF
42
Show member pathways
11.27 IFNG TNF
43 11.23 IFNG IL1B TNF
44 11.21 IL1B TNF
45 11.16 IL1B TNF
46 11.11 CIITA IFNG IL1B
47 11.05 IFNG IL1B
48 11.04 IFNG IL1B TNF
49 10.99 IL1B TNF
50 10.84 IL1B TNF

GO Terms for Staphylococcal Toxic Shock Syndrome

Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 HMGB1 IFNG IGHE IL1B TNF
2 external side of plasma membrane GO:0009897 8.8 IFNG IGHE TNF

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 47)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.95 CIITA HMGB1 IFNG TNF
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.93 CIITA HMGB1 IFNG IL1B TNF
3 positive regulation of transcription, DNA-templated GO:0045893 9.9 CIITA IFNG IL1B TNF
4 positive regulation of gene expression GO:0010628 9.87 IFNG IL1B TNF
5 positive regulation of apoptotic process GO:0043065 9.87 HMGB1 IFNG TNF
6 inflammatory response GO:0006954 9.83 CIITA HMGB1 IL1B TNF
7 defense response to bacterium GO:0042742 9.81 IFNG IGHE TNF
8 positive regulation of T cell proliferation GO:0042102 9.7 IFNG IL1B
9 humoral immune response GO:0006959 9.7 IFNG TNF
10 positive regulation of tumor necrosis factor production GO:0032760 9.69 HMGB1 IFNG
11 positive regulation of cell adhesion GO:0045785 9.69 IFNG TNF
12 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.68 HMGB1 TNF
13 positive regulation of interferon-gamma production GO:0032729 9.68 IL1B TNF
14 extrinsic apoptotic signaling pathway GO:0097191 9.68 IFNG TNF
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 IL1B TNF
16 protein kinase B signaling GO:0043491 9.67 IL1B TNF
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 IL1B TNF
18 positive regulation of phagocytosis GO:0050766 9.67 IL1B TNF
19 positive regulation of JNK cascade GO:0046330 9.67 HMGB1 IL1B TNF
20 protein import into nucleus, translocation GO:0000060 9.66 IFNG TNF
21 positive regulation of interleukin-8 production GO:0032757 9.66 IL1B TNF
22 positive regulation of interleukin-1 beta secretion GO:0050718 9.65 HMGB1 IFNG
23 positive regulation of interleukin-12 production GO:0032735 9.65 HMGB1 IFNG
24 regulation of insulin secretion GO:0050796 9.65 IFNG IL1B TNF
25 immune response GO:0006955 9.65 CIITA IFNG IGHE IL1B TNF
26 positive regulation of protein complex assembly GO:0031334 9.64 IFNG TNF
27 positive regulation of interleukin-6 secretion GO:2000778 9.63 HMGB1 IL1B
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 HMGB1 TNF
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.62 IL1B TNF
30 positive regulation of osteoclast differentiation GO:0045672 9.62 IFNG TNF
31 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
32 negative regulation of growth of symbiont in host GO:0044130 9.61 IFNG TNF
33 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.59 IL1B TNF
34 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
35 regulation of defense response to virus by host GO:0050691 9.58 IFNG IL1B
36 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IFNG IL1B TNF
37 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.57 IFNG IL1B
38 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 CIITA IFNG
39 regulation of establishment of endothelial barrier GO:1903140 9.55 IL1B TNF
40 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
41 positive regulation of protein phosphorylation GO:0001934 9.5 IFNG IL1B TNF
42 sequestering of triglyceride GO:0030730 9.46 IL1B TNF
43 positive regulation of interleukin-6 production GO:0032755 9.43 IL1B TNF
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
45 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.33 IFNG IL1B TNF
46 positive regulation of chemokine biosynthetic process GO:0045080 9.13 IFNG IL1B TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 HMGB1 IFNG IL1B TNF

Sources for Staphylococcal Toxic Shock Syndrome

3 CDC
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10 dbSNP
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16 ExPASy
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36 IUPHAR
37 KEGG
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42 MeSH
43 MESH via Orphanet
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
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70 UMLS via Orphanet
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