MCID: STP004
MIFTS: 45

Staphylococcal Toxic Shock Syndrome

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

MalaCards integrated aliases for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 49 69
Bacterial Toxic-Shock Syndrome 49 55
Staphylococcal Toxic-Shock Syndrome 55
Staphylococcal Tss 55
Bacterial Tss 55

Characteristics:

Orphanet epidemiological data:

55
bacterial toxic-shock syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
staphylococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A48.3
UMLS via Orphanet 70 C3714602
UMLS 69 C3714602

Summaries for Staphylococcal Toxic Shock Syndrome

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 36234Disease definitionBacterial toxic shock syndrome (TSS) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. TSS is mediated by superantigenic toxins, usually caused by an infection with Staphylococcus aureus in staphylococcal TSS (see this term) or Streptococcus pyogenes in streptococcal TSS (see this term).EpidemiologyThe worldwide prevalence is estimated at 1/30, 000.Clinical descriptionThe disease affects mainly young adult women with no previous medical conditions. However, non-menstrual TSS, which can also be observed in men and children, represents up to 50% of Staphylococcal TSS cases. Onset is sudden and includes high fever (>38.9°C), nausea, diarrhea, vomiting, myalgia, abdominal pain and sore throat. Staphylococcal TSS almost always exhibits an erythematous rash and skin peeling as one of its manifestations, whereas it is very rarely seen in streptococcal TSS, which can show signs of soft tissue infection. Serious manifestations include confusion, shock, renal and myocardial dysfunction, acute respiratory distress syndrome (ARDS; see this term) and coma.EtiologyStaphylococcal TSS is due to an infection with Staphylococcus aureus and streptococcal TSS is due to an infection with Streptococcus pyogenes, or rarely, group C or G Streptococcus. Superantigens produced by both bacteria are responsible for the massive and sudden immune reaction seen in TSS. Both forms have been associated with recent traumas (surgery or childbirth) and viral infections, while staphylococcal TSS has also been associated with high absorbency tampon use.Visit the Orphanet disease page for more resources. Last updated: 11/4/2015

MalaCards based summary : Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and burns. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rifampin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes.

Related Diseases for Staphylococcal Toxic Shock Syndrome

Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 31.0 CIITA HMGB1 IFNG IL1B TNF
2 burns 30.1 IL1B TNF
3 dermatitis, atopic 29.5 IFNG IGHE TNF
4 staphylococcal scarlet fever 11.6
5 stromal keratitis 10.3 CIITA TNF
6 macrophage activation syndrome 10.3 HMGB1 TNF
7 suppurative cholangitis 10.2 HMGB1 TNF
8 autoimmune myocarditis 10.2 IFNG TNF
9 chronic beryllium disease 10.2 IFNG TNF
10 trichosporonosis 10.2 IFNG TNF
11 clonorchiasis 10.2 IFNG TNF
12 orofacial granulomatosis 10.2 IFNG TNF
13 microscopic colitis 10.2 IFNG TNF
14 meconium aspiration syndrome 10.2 IFNG TNF
15 tuberculous peritonitis 10.2 IFNG TNF
16 soft tissue sarcoma 10.2 IFNG TNF
17 cytomegalovirus retinitis 10.2 IFNG TNF
18 posterior uveitis 10.2 IFNG TNF
19 poliomyelitis 10.2 IFNG TNF
20 primary systemic mycosis 10.2 IFNG TNF
21 intermediate uveitis 10.2 IFNG TNF
22 coccidiosis 10.2 IFNG TNF
23 hemorrhagic fever 10.2 IFNG TNF
24 erythema multiforme 10.2 IFNG TNF
25 pleural tuberculosis 10.2 IFNG TNF
26 spotted fever 10.2 IFNG TNF
27 hematopoietic stem cell transplantation 10.2 IFNG TNF
28 lichen disease 10.2 IFNG TNF
29 cytomegalovirus infection 10.2 IFNG TNF
30 plasmodium vivax malaria 10.2 IFNG TNF
31 hepatitis e 10.2 IFNG TNF
32 lepromatous leprosy 10.2 IFNG TNF
33 hypersensitivity reaction type iv disease 10.2 IFNG TNF
34 acute graft versus host disease 10.2 IFNG TNF
35 pleurisy 10.2 IFNG TNF
36 opportunistic mycosis 10.2 IFNG TNF
37 paracoccidioidomycosis 10.1 IFNG TNF
38 mixed connective tissue disease 10.1 IFNG TNF
39 atopic keratoconjunctivitis 10.1 IFNG IGHE
40 echinococcosis 10.1 IFNG TNF
41 hyper ige syndrome 10.1 IFNG IGHE
42 melioidosis 10.1 IFNG TNF
43 reactive arthritis 10.1 IFNG TNF
44 brucellosis 10.1 IFNG TNF
45 toxic oil syndrome 10.1 IFNG IGHE
46 hand, foot and mouth disease 10.1 HMGB1 IFNG
47 peanut allergy 10.1 IFNG IGHE
48 leprosy 3 10.1 IFNG TNF
49 dengue hemorrhagic fever 10.1 IFNG TNF
50 severe acute respiratory syndrome 10.1 IFNG TNF

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to Staphylococcal Toxic Shock Syndrome

Symptoms & Phenotypes for Staphylococcal Toxic Shock Syndrome

Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

Drugs for Staphylococcal Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4 13292-46-1 5381226 5458213
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
5 Clavulanic Acid Phase 4
6 Rho(D) Immune Globulin Phase 4
7 gamma-Globulins Phase 4
8 Clindamycin palmitate Phase 4
9 Clindamycin phosphate Phase 4
10 Amoxicillin-Potassium Clavulanate Combination Phase 4
11 Anti-Bacterial Agents Phase 4
12 Pharmaceutical Solutions Phase 4
13 Anti-Infective Agents Phase 4
14 Immunoglobulins Phase 4
15 Immunoglobulins, Intravenous Phase 4
16 Antibiotics, Antitubercular Phase 4
17 Antibodies Phase 4
18 beta-Lactamase Inhibitors Phase 4
19 proline Nutraceutical Phase 4
20
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
21 Adjuvants, Immunologic Phase 1
22 Gastrointestinal Agents Phase 1
23 Vaccines Phase 1
24 Antacids Phase 1
25 Anti-Ulcer Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin
2 Phase I STEBVax in Healthy Adults Completed NCT00974935 Phase 1 Aluminum hydroxide

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

Anatomical Context for Staphylococcal Toxic Shock Syndrome

MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

38
Skin, T Cells, Monocytes, B Cells, Testes

Publications for Staphylococcal Toxic Shock Syndrome

Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50) (show all 80)
# Title Authors Year
1
Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. ( 29350159 )
2018
2
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28580155 )
2017
3
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28721224 )
2017
4
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. ( 27863161 )
2017
5
Acute encephalopathy with biphasic seizures and late reduced diffusion associated with staphylococcal toxic shock syndrome caused by burns. ( 27117386 )
2016
6
Unusual staphylococcal toxic shock syndrome presenting as a scarlet-like fever. ( 26543563 )
2015
7
Staphylococcal toxic shock syndrome caused by tampon use. ( 25692047 )
2015
8
A fatal case of staphylococcal toxic shock syndrome. ( 26265799 )
2015
9
Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. ( 24816557 )
2014
10
Evidence of Staphylococcal Toxic Shock Syndrome caused by MRSA in a Mother-Newborn Pair. ( 25260039 )
2014
11
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. ( 24423010 )
2014
12
Images in clinical medicine. Staphylococcal toxic shock syndrome. ( 23984732 )
2013
13
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. ( 22431984 )
2012
14
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. ( 21860665 )
2011
15
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. ( 21253349 )
2010
16
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. ( 20367234 )
2010
17
Staphylococcal toxic shock syndrome: mechanisms and management. ( 21308522 )
2010
18
Staphylococcal toxic shock syndrome presenting as acute respiratory distress and cor pulmonale. ( 20196940 )
2010
19
Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity. ( 19911998 )
2009
20
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. ( 19402965 )
2009
21
Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vbeta signature in peripheral blood of a 12-year-old boy. ( 18277923 )
2008
22
Staphylococcal toxic shock syndrome. ( 18697637 )
2008
23
Symmetrical Peripheral Gangrene complicating Staphylococcal Toxic Shock Syndrome. ( 27408131 )
2008
24
Analysis of superantigenic toxin Vbeta T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. ( 18373692 )
2008
25
Staphylococcal toxic shock syndrome toxin-1 induces the translocation and secretion of high mobility group-1 protein from both activated T cells and monocytes. ( 19009026 )
2008
26
Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. ( 17409134 )
2007
27
A rare case of staphylococcal toxic shock syndrome after abdominoplasty. ( 19341642 )
2007
28
Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics. ( 16447124 )
2006
29
Staphylococcal toxic shock syndrome: still a problem. ( 15963025 )
2005
30
Reemergence of staphylococcal toxic shock syndrome in the United States since 2000. ( 15815055 )
2005
31
Staphylococcal toxic shock syndrome: still a problem. ( 16116687 )
2005
32
Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. ( 15184497 )
2004
33
Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. ( 15122526 )
2004
34
Expansion of TcRalphabeta+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. ( 15034239 )
2004
35
A 37-year-old man with a febrile illness. Staphylococcal toxic shock syndrome. ( 17171845 )
2003
36
Staphylococcal toxic shock syndrome in a small infant. ( 11938403 )
2002
37
Postoperative staphylococcal toxic shock syndrome due to pre-existing staphylococcal infection: case report and review of the literature. ( 11510574 )
2001
38
Bacteremic nonmenstrual staphylococcal toxic shock syndrome associated with enterotoxins A and C. ( 11170971 )
2001
39
Staphylococcal toxic shock syndrome. Suspicion and prevention are keys to control. ( 11675982 )
2001
40
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. ( 10721486 )
2000
41
Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis. ( 10329825 )
1999
42
Interaction of staphylococcal toxic shock syndrome toxin-1 and enterotoxin A on T cell proliferation and TNFI+ secretion in human blood mononuclear cells. ( 22346398 )
1999
43
Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. ( 10405382 )
1999
44
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. ( 8643591 )
1996
45
Staphylococcal toxic shock syndrome associated with human immunodeficiency virus infection: report of a case with bacteremia. ( 8722964 )
1996
46
Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. ( 8821303 )
1995
47
Staphylococcal toxic shock syndrome in a paediatric burn unit. ( 7880413 )
1994
48
Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1. ( 8253961 )
1993
49
Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. ( 1612731 )
1992
50
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. ( 1639516 )
1992

Variations for Staphylococcal Toxic Shock Syndrome

Expression for Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for Staphylococcal Toxic Shock Syndrome

Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CIITA HMGB1 IFNG IGHE IL1B TNF
2
Show member pathways
13.12 CIITA IFNG IGHE IL1B TNF
3
Show member pathways
12.99 HMGB1 IFNG IL1B TNF
4
Show member pathways
12.66 CIITA IFNG IL1B TNF
5
Show member pathways
12.6 CIITA IFNG IL1B TNF
6
Show member pathways
12.51 HMGB1 IFNG IL1B TNF
7
Show member pathways
12.48 IFNG IL1B TNF
8
Show member pathways
12.45 IFNG IGHE TNF
9
Show member pathways
12.41 IFNG IL1B TNF
10
Show member pathways
12.4 IFNG IL1B TNF
11
Show member pathways
12.35 IFNG IL1B TNF
12 12.34 CIITA IFNG IL1B TNF
13
Show member pathways
12.26 IFNG IL1B TNF
14
Show member pathways
12.17 IFNG IL1B TNF
15
Show member pathways
12.16 IFNG IL1B TNF
16
Show member pathways
12.12 IFNG IL1B TNF
17
Show member pathways
12.03 IFNG IL1B TNF
18
Show member pathways
12.01 IFNG IL1B TNF
19 11.95 IFNG IL1B TNF
20 11.91 IFNG IL1B TNF
21
Show member pathways
11.89 CIITA IFNG IL1B TNF
22 11.85 IFNG IL1B TNF
23 11.82 IGHE IL1B TNF
24
Show member pathways
11.78 IFNG IL1B TNF
25 11.73 IFNG IL1B TNF
26 11.71 CIITA IFNG IL1B TNF
27
Show member pathways
11.69 IFNG IL1B
28 11.69 IFNG IL1B TNF
29 11.63 IFNG IL1B TNF
30 11.58 IFNG IL1B TNF
31 11.52 IL1B TNF
32
Show member pathways
11.5 IFNG TNF
33
Show member pathways
11.5 HMGB1 IFNG IL1B TNF
34
Show member pathways
11.49 IFNG IL1B TNF
35 11.48 IFNG TNF
36 11.45 IL1B TNF
37 11.41 IFNG TNF
38
Show member pathways
11.4 IFNG TNF
39 11.39 IL1B TNF
40 11.38 HMGB1 TNF
41 11.36 IFNG IL1B TNF
42 11.33 IFNG IL1B TNF
43
Show member pathways
11.32 IL1B TNF
44 11.31 IFNG IL1B TNF
45 11.26 IFNG IL1B TNF
46
Show member pathways
11.24 IFNG TNF
47 11.22 IL1B TNF
48 11.16 IL1B TNF
49 11.15 CIITA IFNG IL1B
50 11.09 IFNG IL1B TNF

GO Terms for Staphylococcal Toxic Shock Syndrome

Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 HMGB1 IFNG IGHE IL1B TNF

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.96 CIITA HMGB1 IL1B TNF
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.9 CIITA HMGB1 IFNG TNF
3 positive regulation of gene expression GO:0010628 9.84 IFNG IL1B TNF
4 regulation of receptor activity GO:0010469 9.83 HMGB1 IFNG IL1B TNF
5 inflammatory response GO:0006954 9.78 CIITA HMGB1 IL1B TNF
6 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG IL1B TNF
7 humoral immune response GO:0006959 9.67 IFNG TNF
8 positive regulation of interleukin-6 production GO:0032755 9.66 IL1B TNF
9 protein kinase B signaling GO:0043491 9.65 IL1B TNF
10 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.65 HMGB1 TNF
11 positive regulation of interferon-gamma production GO:0032729 9.65 IL1B TNF
12 extrinsic apoptotic signaling pathway GO:0097191 9.64 IFNG TNF
13 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.64 IL1B TNF
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 IL1B TNF
15 positive regulation of phagocytosis GO:0050766 9.63 IL1B TNF
16 protein import into nucleus, translocation GO:0000060 9.62 IFNG TNF
17 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TNF
18 positive regulation of interleukin-12 production GO:0032735 9.61 HMGB1 IFNG
19 positive regulation of protein complex assembly GO:0031334 9.61 IFNG TNF
20 positive regulation of JNK cascade GO:0046330 9.61 HMGB1 IL1B TNF
21 positive regulation of NF-kappaB import into nucleus GO:0042346 9.59 IL1B TNF
22 positive regulation of interleukin-6 secretion GO:2000778 9.58 HMGB1 IL1B
23 positive regulation of osteoclast differentiation GO:0045672 9.58 IFNG TNF
24 regulation of insulin secretion GO:0050796 9.58 IFNG IL1B TNF
25 negative regulation of lipid catabolic process GO:0050995 9.57 IL1B TNF
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.55 IL1B TNF
27 immune response GO:0006955 9.55 CIITA IFNG IGHE IL1B TNF
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL1B TNF
29 positive regulation of chemokine biosynthetic process GO:0045080 9.51 IL1B TNF
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 IFNG IL1B TNF
31 regulation of establishment of endothelial barrier GO:1903140 9.49 IL1B TNF
32 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
33 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
34 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.13 IFNG IL1B TNF
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 HMGB1 IFNG IL1B TNF

Sources for Staphylococcal Toxic Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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