MCID: STP004
MIFTS: 36

Staphylococcal Toxic Shock Syndrome malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 45
Bacterial Toxic-Shock Syndrome 45 51
Staphylococcal Toxic-Shock Syndrome 51
 
Toxic Shock Syndrome 65
Staphylococcal Tss 51
Bacterial Tss 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
bacterial toxic-shock syndrome:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age


External Ids:

Orphanet51 36234, 99919
ICD10 via Orphanet28 A48.3

Summaries for Staphylococcal Toxic Shock Syndrome

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MalaCards based summary: Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to dermatitis and toxic shock syndrome. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways are Cellular roles of Anthrax toxin and LDL Oxidation in Atherogenesis. Affiliated tissues include t cells, monocytes and b cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Related Diseases for Staphylococcal Toxic Shock Syndrome

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Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.7IL1B, TNF
2toxic shock syndrome11.2
3bacteremia10.3
4sudden infant death syndrome10.3
5aspergillosis10.3
6burns10.3
7scarlet fever10.3
8atopic dermatitis10.3
9staphylococcal scarlet fever10.3
10endotheliitis10.2CIITA, TNF
11meckel's diverticulitis10.2IL1B, TNF
12peyronie's disease10.2IL1B, TNF
13plantar nerve lesion10.2IL1B, TNF
14larynx sarcoma10.2IL1B, TNF
15waardenburg syndrome type 410.2IL1B, TNF
16lymphoepithelioma-like carcinoma10.2IL1B, TNF
17wissler's syndrome10.2IL1B, TNF
18calpainopathy10.2IL1B, TNF
19intermediate cell type choroid melanoma10.2IL1B, TNF
20fallopian tube cystadenofibroma10.2IL1B, TNF
21hepatic angiomyolipoma10.2IL1B, TNF
22congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay10.2IL1B, TNF
23stalker chitayat syndrome10.2IL1B, TNF
24lacrimal gland adenocarcinoma10.2IL1B, TNF
25migraine with aura10.2IL1B, TNF
26henoch-schoenlein purpura10.2IL1B, TNF
27endocervicitis10.2IL1B, TNF
28kartagener syndrome10.2IL1B, TNF
29endophthalmitis10.2IL1B, TNF
30common bile duct disease10.2IL1B, TNF
31thymus basaloid carcinoma10.2IL1B, TNF
32clear cell renal cell carcinoma10.2IL1B, TNF
33acquired immunodeficiency syndrome10.2IL1B, TNF
34osmotic diarrhea10.2IL1B, TNF
35acute allergic serous otitis media10.2IL1B, TNF
36sarcoidosis, early-onset10.2IL1B, TNF
37chronic mucocutaneous candidiasis10.1IL1B, TNF
38senile angioma10.1IL1B, TNF
39familial mediterranean fever, ad10.1IL1B, TNF
40protein-energy malnutrition10.1IL1B, TNF
41pericardium cancer10.1IL1B, TNF
42pyloric stenosis10.1IL1B, TNF
43periapical periodontitis10.1IL1B, TNF
44single ventricular heart10.1IL1B, TNF
45bullous systemic lupus erythematosus10.1IGHE, TNF
46glioblastoma multiforme10.1IL1B, TNF
47pneumonia10.1IL1B, TNF
48balanitis xerotica obliterans10.1IL1B, TNF
49balanitis10.1IL1B, TNF
50mixed cerebral palsy10.1IL1B, TNF

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to staphylococcal toxic shock syndrome

Symptoms for Staphylococcal Toxic Shock Syndrome

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Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

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Drugs for Staphylococcal Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins, IntravenousPhase 2203
2Rho(D) Immune GlobulinPhase 2198
3
Aluminum hydroxideapprovedPhase 1169
Synonyms:
Al(OH)3
Aluminiumhydroxid
 
Aluminum Hydroxide
Aluminum hydroxide
Dermadrox
4methicillin142

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot StudyRecruitingNCT02219165Phase 2
2Phase I STEBVax in Healthy AdultsCompletedNCT00974935Phase 1
3rTSST-1 Variant Vaccine Phase 1CompletedNCT02340338Phase 1
4Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus AureusRecruitingNCT01141101

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

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Anatomical Context for Staphylococcal Toxic Shock Syndrome

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MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

33
T cells, Monocytes, B cells, Testes, Colon

Animal Models for Staphylococcal Toxic Shock Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Staphylococcal Toxic Shock Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9CIITA, IFNG, IGHE, IL1B, TNF
2MP:00053766.8CIITA, HMGB1, IFNG, IGHE, IL1B, TNF

Publications for Staphylococcal Toxic Shock Syndrome

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Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Unusual staphylococcal toxic shock syndrome presenting as a scarlet-like fever. (26543563)
2015
2
Evidence of Staphylococcal Toxic Shock Syndrome caused by MRSA in a Mother-Newborn Pair. (25260039)
2014
3
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. (24423010)
2014
4
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. (22431984)
2012
5
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. (21860665)
2011
6
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. (20367234)
2010
7
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. (21253349)
2010
8
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. (19402965)
2009
9
Analysis of superantigenic toxin Vbeta T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. (18373692)
2008
10
A rare case of staphylococcal toxic shock syndrome after abdominoplasty. (19341642)
2007
11
Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. (17409134)
2007
12
Staphylococcal toxic shock syndrome: still a problem. (16116687)
2005
13
Staphylococcal toxic shock syndrome: still a problem. (15963025)
2005
14
Reemergence of staphylococcal toxic shock syndrome in the United States since 2000. (15815055)
2005
15
Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. (15122526)
2004
16
Expansion of TcRalphabeta+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. (15034239)
2004
17
Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. (15184497)
2004
18
A 37-year-old man with a febrile illness. Staphylococcal toxic shock syndrome. (17171845)
2003
19
Staphylococcal toxic shock syndrome in a small infant. (11938403)
2002
20
Postoperative staphylococcal toxic shock syndrome due to pre-existing staphylococcal infection: case report and review of the literature. (11510574)
2001
21
Bacteremic nonmenstrual staphylococcal toxic shock syndrome associated with enterotoxins A and C. (11170971)
2001
22
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. (10721486)
2000
23
Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. (10405382)
1999
24
Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis. (10329825)
1999
25
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. (8643591)
1996
26
Staphylococcal toxic shock syndrome associated with human immunodeficiency virus infection: report of a case with bacteremia. (8722964)
1996
27
Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. (8821303)
1995
28
Staphylococcal toxic shock syndrome in a paediatric burn unit. (7880413)
1994
29
Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1. (8253961)
1993
30
Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. (1612731)
1992
31
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. (1639516)
1992
32
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1. (2313089)
1990
33
Causes of staphylococcal toxic shock syndrome. (2380842)
1990
34
Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. (1696937)
1990
35
Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria. (2928649)
1989
36
Chick embryo assay for staphylococcal toxic shock syndrome toxin-1. (3231112)
1988
37
Detection of staphylococcal toxic shock syndrome toxin 1 by a latex agglutination kit. (3194712)
1988
38
Comparison of two newly developed forms of an enzyme-linked immunosorbent assay for the detection of staphylococcal toxic shock syndrome toxin-1 (TSST-1). (3447385)
1987
39
Affinity purification of staphylococcal toxic shock syndrome toxin 1 and its pathologic effects in rabbits. (3943896)
1986
40
Outbreak of non-menstrual fatal staphylococcal toxic shock syndrome in India. (2878296)
1986
41
Latex agglutination test for staphylococcal toxic shock syndrome toxin 1. (3082921)
1986
42
Regulation of staphylococcal toxic shock syndrome toxin-1 and total exoprotein production by magnesium ion. (3527988)
1986
43
Staphylococcal toxic shock syndrome. (3788008)
1986
44
Disseminated aspergillosis in a patient with staphylococcal toxic shock syndrome. (3748246)
1986
45
Staphylococcal toxic-shock syndrome: mixture of toxins including endotoxin. (6639769)
1983
46
Varicella zoster and staphylococcal toxic shock syndrome in a young man. (6218314)
1983
47
Staphylococcal toxic shock syndrome--an autopsy report. (6668025)
1983
48
Staphylococcal toxic shock syndrome following herniorrhaphy in a male. (6960191)
1982
49
Risk factors for staphylococcal toxic-shock syndrome. (7315834)
1981
50
Staphylococcal toxic shock syndrome. (6951568)
1981

Variations for Staphylococcal Toxic Shock Syndrome

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Expression for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL1B, TNF
29.5IL1B, TNF
39.5IL1B, TNF
4
Show member pathways
9.5IL1B, TNF
59.5IL1B, TNF
69.4IFNG, TNF
7
Show member pathways
9.4IFNG, TNF
89.4IFNG, TNF
9
Show member pathways
9.4IFNG, TNF
10
Show member pathways
9.4IFNG, TNF
119.2HMGB1, TNF
12
Show member pathways
8.9IFNG, IL1B, TNF
13
Show member pathways
8.9IFNG, IL1B, TNF
14
B cell receptor signaling pathway (KEGG)
Show member pathways
8.9IFNG, IL1B, TNF
158.9IFNG, IL1B, TNF
16
Show member pathways
8.9IFNG, IL1B, TNF
17
Show member pathways
8.9IFNG, IL1B, TNF
18
Show member pathways
8.9IFNG, IL1B, TNF
198.9IFNG, IL1B, TNF
208.9IFNG, IL1B, TNF
218.9IFNG, IL1B, TNF
228.9IFNG, IL1B, TNF
238.9IFNG, IL1B, TNF
24
Show member pathways
8.9IFNG, IL1B, TNF
25
Show member pathways
8.9IFNG, IL1B, TNF
268.9IFNG, IL1B, TNF
278.9IFNG, IL1B, TNF
288.9IFNG, IL1B, TNF
298.9CIITA, IFNG, IL1B
30
Show member pathways
8.5CIITA, IFNG, IL1B, TNF
318.5CIITA, IFNG, IL1B, TNF
32
Show member pathways
8.5CIITA, IFNG, IL1B, TNF
33
Show member pathways
8.5CIITA, IFNG, IL1B, TNF
348.5CIITA, IFNG, IL1B, TNF
35
Show member pathways
8.1HMGB1, IFNG, IL1B, TNF
36
Show member pathways
7.1CIITA, HMGB1, IFNG, IGHE, IL1B, TNF

GO Terms for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3IFNG, IGHE, TNF
2extracellular regionGO:00055767.6HMGB1, IFNG, IGHE, IL1B, TNF

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:003073010.3IL1B, TNF
2regulation of establishment of endothelial barrierGO:190314010.3IL1B, TNF
3chronic inflammatory response to antigenic stimulusGO:000243910.2IL1B, TNF
4negative regulation of lipid catabolic processGO:005099510.2IL1B, TNF
5positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
6positive regulation of JUN kinase activityGO:004350710.2IL1B, TNF
7positive regulation of interferon-gamma productionGO:003272910.2IL1B, TNF
8positive regulation of heterotypic cell-cell adhesionGO:003411610.2IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:004234610.2IL1B, TNF
10positive regulation of fever generationGO:003162210.2IL1B, TNF
11lipopolysaccharide-mediated signaling pathwayGO:003166310.1IL1B, TNF
12protein kinase B signalingGO:004349110.1IL1B, TNF
13positive regulation of interleukin-8 productionGO:003275710.1IL1B, TNF
14protein import into nucleus, translocationGO:000006010.1IFNG, TNF
15extrinsic apoptotic signaling pathwayGO:009719110.1IFNG, TNF
16regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.1IL1B, TNF
17positive regulation of MHC class II biosynthetic processGO:004534810.1CIITA, IFNG
18humoral immune responseGO:000695910.0IFNG, TNF
19positive regulation of phagocytosisGO:005076610.0IL1B, TNF
20positive regulation of interleukin-6 biosynthetic processGO:004541010.0IFNG, IL1B
21cellular response to organic cyclic compoundGO:007140710.0IL1B, TNF
22negative regulation of growth of symbiont in hostGO:004413010.0IFNG, TNF
23positive regulation of osteoclast differentiationGO:00456729.9IFNG, TNF
24inflammatory response to antigenic stimulusGO:00024379.8HMGB1, IL1B
25positive regulation of cell adhesionGO:00457859.8IFNG, TNF
26neutrophil chemotaxisGO:00305939.8IFNG, IL1B
27positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00432809.7HMGB1, TNF
28positive regulation of calcidiol 1-monooxygenase activityGO:00605599.7IFNG, IL1B, TNF
29positive regulation of interleukin-1 beta secretionGO:00507189.6HMGB1, IFNG
30positive regulation of T cell proliferationGO:00421029.6IFNG, IL1B
31positive regulation of chemokine biosynthetic processGO:00450809.6IFNG, IL1B, TNF
32positive regulation of membrane protein ectodomain proteolysisGO:00510449.6IFNG, IL1B, TNF
33positive regulation of tumor necrosis factor productionGO:00327609.5HMGB1, IFNG
34regulation of insulin secretionGO:00507969.5IFNG, IL1B, TNF
35negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1B, TNF
36cellular response to lipopolysaccharideGO:00712229.4IFNG, IL1B, TNF
37negative regulation of gene expressionGO:00106299.4IFNG, IL1B, TNF
38defense response to bacteriumGO:00427429.3IFNG, IGHE, TNF
39positive regulation of nitric oxide biosynthetic processGO:00454299.3IFNG, IL1B, TNF
40positive regulation of interleukin-6 productionGO:00327559.2HMGB1, IL1B, TNF
41positive regulation of apoptotic processGO:00430659.1HMGB1, IL1B, TNF
42cytokine-mediated signaling pathwayGO:00192219.0CIITA, IFNG, IL1B
43positive regulation of JNK cascadeGO:00463309.0HMGB1, IL1B, TNF
44positive regulation of ERK1 and ERK2 cascadeGO:00703748.9HMGB1, IL1B, TNF
45positive regulation of gene expressionGO:00106288.9IFNG, IL1B, TNF
46positive regulation of transcription, DNA-templatedGO:00458938.8CIITA, IFNG, IL1B, TNF
47inflammatory responseGO:00069548.7CIITA, HMGB1, IL1B, TNF
48immune responseGO:00069558.3CIITA, IFNG, IGHE, IL1B, TNF
49positive regulation of transcription from RNA polymerase II promoterGO:00459447.6CIITA, HMGB1, IFNG, IL1B, TNF
50negative regulation of transcription from RNA polymerase II promoterGO:00001227.3CIITA, HMGB1, IFNG, IL1B, TNF

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.1HMGB1, IFNG, IL1B, TNF

Sources for Staphylococcal Toxic Shock Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet