MCID: STP004
MIFTS: 45

Staphylococcal Toxic Shock Syndrome malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

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Sources:
45NIH Rare Diseases, 65UMLS, 51Orphanet, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 45 65
Bacterial Toxic-Shock Syndrome 45 51
Staphylococcal Toxic-Shock Syndrome 51
 
Staphylococcal Tss 51
Bacterial Tss 51

Characteristics:

Orphanet epidemiological data:

51
bacterial toxic-shock syndrome:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Orphanet51 36234, 99919
ICD10 via Orphanet28 A48.3
UMLS65 C3714602

Summaries for Staphylococcal Toxic Shock Syndrome

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MalaCards based summary: Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and staphylococcal scarlet fever, and has symptoms including presyncope, syncope and dizziness. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways are amb2 Integrin signaling and Pertussis. Affiliated tissues include thyroid, prostate and liver.

Related Diseases for Staphylococcal Toxic Shock Syndrome

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Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1toxic shock syndrome11.7
2staphylococcal scarlet fever11.6
3macrophagic myofasciitis10.4HMGB1, TNF
4androgen insensitivity syndrome, mild10.4HMGB1, TNF
5goat milk allergy10.4IGHE, TNF
6hepatoid adenocarcinoma10.3IGHE, TNF
7polycythemia10.3IL1B, TNF
8plantar nerve lesion10.3IL1B, TNF
9peyronie's disease10.3IL1B, TNF
10mammary paget's disease10.3IL1B, TNF
11waardenburg syndrome type 410.3IL1B, TNF
12lujo hemorrhagic fever10.3IL1B, TNF
13residual stage angle-closure glaucoma10.3IL1B, TNF
14testicular granulosa cell tumor10.3IL1B, TNF
15refractory plasma cell neoplasm10.3IL1B, TNF
16skin conditions10.3IL1B, TNF
17postsurgical hypothyroidism10.3IL1B, TNF
18rubeosis iridis10.3IL1B, TNF
19ureteral disease10.3IL1B, TNF
20auricular cancer10.3IL1B, TNF
21duodenum cancer10.3IL1B, TNF
22peripheral retinal degeneration10.3IL1B, TNF
23benign focal amyotrophy10.3IL1B, TNF
24opportunistic bacterial infectious disease10.3IL1B, TNF
25dentin caries10.2IL1B, TNF
26trench fever10.2IL1B, TNF
27placental abruption10.2IL1B, TNF
28secretory diarrhea10.2IL1B, TNF
29meige syndrome10.2IL1B, TNF
30sarcoidosis, early-onset10.2IL1B, TNF
31submandibular gland disease10.2IL1B, TNF
32tracheal stenosis10.2IL1B, TNF
33periodontal disease10.2IL1B, TNF
34blue color blindness10.2IL1B, TNF
35lateral sclerosis10.2IL1B, TNF
36villoglandular variant cervical mucinous adenocarcinoma10.2IL1B, TNF
37acrodysostosis10.2IL1B, TNF
38uterine corpus epithelioid leiomyoma10.2IGHE, TNF
39porphyria10.2IL1B, TNF
40reflex sympathetic dystrophy10.2IL1B, TNF
41pediatric infratentorial ependymoma10.2IL1B, TNF
42single ventricular heart10.2IL1B, TNF
43chronic cholangitis10.2IL1B, TNF
44funisitis10.2IL1B, TNF
45meningitis10.2IL1B, TNF
46hypoglycemic coma10.2IL1B, TNF
47leptospirosis10.2IL1B, TNF
48granulomatous orchitis10.2IL1B, TNF
49peritoneal mesothelioma10.2IL1B, TNF
50methylmalonic acidemia10.2IL1B, TNF

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to staphylococcal toxic shock syndrome

Symptoms for Staphylococcal Toxic Shock Syndrome

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UMLS symptoms related to Staphylococcal Toxic Shock Syndrome:


presyncope, syncope, dizziness

Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

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Drugs for Staphylococcal Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunologic FactorsPhase 2, Phase 118483
2Pharmaceutical SolutionsPhase 27004
3Rho(D) Immune GlobulinPhase 2206
4Immunoglobulins, IntravenousPhase 2211
5ImmunoglobulinsPhase 24477
6AntibodiesPhase 24477
7
Aluminum hydroxideapprovedPhase 1178
Synonyms:
Al(OH)3
Aluminiumhydroxid
 
Aluminum Hydroxide
Aluminum hydroxide
Dermadrox
8VaccinesPhase 16085
9Adjuvants, ImmunologicPhase 11783
10Gastrointestinal AgentsPhase 16401
11Anti-Ulcer AgentsPhase 11453
12AntacidsPhase 11453
13methicillin148
14Anti-Bacterial Agents9140
15Anti-Infective Agents17220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot StudyRecruitingNCT02219165Phase 2
2Phase I STEBVax in Healthy AdultsCompletedNCT00974935Phase 1
3rTSST-1 Variant Vaccine Phase 1CompletedNCT02340338Phase 1
4Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus AureusCompletedNCT01141101

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

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Anatomical Context for Staphylococcal Toxic Shock Syndrome

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MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

33
Thyroid, Prostate, Liver, Heart, Colon, T cells, Skin

Animal Models for Staphylococcal Toxic Shock Syndrome or affiliated genes

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Publications for Staphylococcal Toxic Shock Syndrome

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Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Unusual staphylococcal toxic shock syndrome presenting as a scarlet-like fever. (26543563)
2015
2
A fatal case of staphylococcal toxic shock syndrome. (26265799)
2015
3
Evidence of Staphylococcal Toxic Shock Syndrome caused by MRSA in a Mother-Newborn Pair. (25260039)
2014
4
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. (24423010)
2014
5
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. (22431984)
2012
6
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. (21860665)
2011
7
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. (20367234)
2010
8
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. (21253349)
2010
9
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. (19402965)
2009
10
Analysis of superantigenic toxin Vbeta T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. (18373692)
2008
11
A rare case of staphylococcal toxic shock syndrome after abdominoplasty. (19341642)
2007
12
Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. (17409134)
2007
13
Staphylococcal toxic shock syndrome: still a problem. (16116687)
2005
14
Staphylococcal toxic shock syndrome: still a problem. (15963025)
2005
15
Reemergence of staphylococcal toxic shock syndrome in the United States since 2000. (15815055)
2005
16
Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. (15122526)
2004
17
Expansion of TcRalphabeta+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. (15034239)
2004
18
Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. (15184497)
2004
19
A 37-year-old man with a febrile illness. Staphylococcal toxic shock syndrome. (17171845)
2003
20
Staphylococcal toxic shock syndrome in a small infant. (11938403)
2002
21
Postoperative staphylococcal toxic shock syndrome due to pre-existing staphylococcal infection: case report and review of the literature. (11510574)
2001
22
Bacteremic nonmenstrual staphylococcal toxic shock syndrome associated with enterotoxins A and C. (11170971)
2001
23
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. (10721486)
2000
24
Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. (10405382)
1999
25
Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis. (10329825)
1999
26
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. (8643591)
1996
27
Staphylococcal toxic shock syndrome associated with human immunodeficiency virus infection: report of a case with bacteremia. (8722964)
1996
28
Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. (8821303)
1995
29
Staphylococcal toxic shock syndrome in a paediatric burn unit. (7880413)
1994
30
Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1. (8253961)
1993
31
Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. (1612731)
1992
32
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. (1639516)
1992
33
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1. (2313089)
1990
34
Causes of staphylococcal toxic shock syndrome. (2380842)
1990
35
Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. (1696937)
1990
36
Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria. (2928649)
1989
37
Chick embryo assay for staphylococcal toxic shock syndrome toxin-1. (3231112)
1988
38
Detection of staphylococcal toxic shock syndrome toxin 1 by a latex agglutination kit. (3194712)
1988
39
Comparison of two newly developed forms of an enzyme-linked immunosorbent assay for the detection of staphylococcal toxic shock syndrome toxin-1 (TSST-1). (3447385)
1987
40
Affinity purification of staphylococcal toxic shock syndrome toxin 1 and its pathologic effects in rabbits. (3943896)
1986
41
Outbreak of non-menstrual fatal staphylococcal toxic shock syndrome in India. (2878296)
1986
42
Latex agglutination test for staphylococcal toxic shock syndrome toxin 1. (3082921)
1986
43
Regulation of staphylococcal toxic shock syndrome toxin-1 and total exoprotein production by magnesium ion. (3527988)
1986
44
Staphylococcal toxic shock syndrome. (3788008)
1986
45
Staphylococcal toxic-shock syndrome: mixture of toxins including endotoxin. (6639769)
1983
46
Varicella zoster and staphylococcal toxic shock syndrome in a young man. (6218314)
1983
47
Staphylococcal toxic shock syndrome--an autopsy report. (6668025)
1983
48
Staphylococcal toxic shock syndrome following herniorrhaphy in a male. (6960191)
1982
49
Risk factors for staphylococcal toxic-shock syndrome. (7315834)
1981
50
Staphylococcal toxic shock syndrome. (6951568)
1981

Variations for Staphylococcal Toxic Shock Syndrome

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Expression for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
19.5HMGB1, TNF
29.4IL1B, TNF
39.4IL1B, TNF
49.4IL1B, TNF
59.4IL1B, TNF
69.4IL1B, TNF
7
Show member pathways
9.4IL1B, TNF
89.4IL1B, TNF
99.4IL1B, TNF
109.4IL1B, TNF
119.4IL1B, TNF
129.4IL1B, TNF
139.4IL1B, TNF
149.4IL1B, TNF
159.4IL1B, TNF
169.4IL1B, TNF
179.4IL1B, TNF
18
Show member pathways
9.4IL1B, TNF
199.0CIITA, IL1B
20
Show member pathways
8.9HMGB1, IL1B, TNF
21
Show member pathways
8.6CIITA, IL1B, TNF
22
Show member pathways
8.6CIITA, IL1B, TNF
238.6CIITA, IL1B, TNF
24
Show member pathways
8.6CIITA, IL1B, TNF
25
Show member pathways
7.5CIITA, HMGB1, IGHE, IL1B, TNF

GO Terms for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328010.1HMGB1, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.1IL1B, TNF
3positive regulation of membrane protein ectodomain proteolysisGO:005104410.1IL1B, TNF
4sequestering of triglycerideGO:003073010.1IL1B, TNF
5regulation of establishment of endothelial barrierGO:190314010.1IL1B, TNF
6positive regulation of chemokine biosynthetic processGO:004508010.1IL1B, TNF
7positive regulation of NF-kappaB import into nucleusGO:004234610.1IL1B, TNF
8positive regulation of nitric oxide biosynthetic processGO:004542910.0IL1B, TNF
9positive regulation of fever generationGO:003162210.0IL1B, TNF
10positive regulation of interleukin-6 secretionGO:200077810.0HMGB1, IL1B
11negative regulation of lipid catabolic processGO:005099510.0IL1B, TNF
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1B, TNF
13regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
14positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9IL1B, TNF
15positive regulation of interferon-gamma productionGO:00327299.9IL1B, TNF
16activation of MAPK activityGO:00001879.9IL1B, TNF
17positive regulation of phagocytosisGO:00507669.8IL1B, TNF
18regulation of insulin secretionGO:00507969.8IL1B, TNF
19positive regulation of JNK cascadeGO:00463309.7HMGB1, IL1B
20positive regulation of ERK1 and ERK2 cascadeGO:00703749.7HMGB1, IL1B
21positive regulation of apoptotic processGO:00430659.7IL1B, TNF
22positive regulation of NF-kappaB transcription factor activityGO:00510929.7IL1B, TNF
23negative regulation of gene expressionGO:00106299.6IL1B, TNF
24leukocyte migrationGO:00509009.5IL1B, TNF
25cellular response to lipopolysaccharideGO:00712229.5IL1B, TNF
26response to glucocorticoidGO:00513849.4HMGB1, IL1B, TNF
27positive regulation of JUN kinase activityGO:00435079.4IL1B, TNF
28defense response to bacteriumGO:00427429.4IGHE, TNF
29agingGO:00075689.4CIITA, IL1B
30positive regulation of protein phosphorylationGO:00019349.2HMGB1, IL1B, TNF
31positive regulation of interleukin-6 productionGO:00327559.2HMGB1, IL1B, TNF
32positive regulation of transcription, DNA-templatedGO:00458939.0CIITA, IL1B, TNF
33inflammatory responseGO:00069548.8CIITA, IL1B, TNF
34negative regulation of transcription from RNA polymerase II promoterGO:00001228.2CIITA, HMGB1, IL1B, TNF
35positive regulation of transcription from RNA polymerase II promoterGO:00459448.1CIITA, HMGB1, IL1B, TNF

Sources for Staphylococcal Toxic Shock Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet