MCID: STP004
MIFTS: 41

Staphylococcal Toxic Shock Syndrome malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

Aliases & Descriptions for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 50 69
Bacterial Toxic-Shock Syndrome 50 56
Staphylococcal Toxic-Shock Syndrome 56
Staphylococcal Tss 56
Bacterial Tss 56

Characteristics:

Orphanet epidemiological data:

56
bacterial toxic-shock syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
staphylococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 34 A48.3

Summaries for Staphylococcal Toxic Shock Syndrome

MalaCards based summary : Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and staphylococcal scarlet fever. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rifampin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and b cells.

Related Diseases for Staphylococcal Toxic Shock Syndrome

Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
id Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 11.6
2 staphylococcal scarlet fever 11.5
3 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 HMGB1 TNF
4 madras motor neuron disease 10.2 HMGB1 TNF
5 choanal atresia, bilateral 10.2 CIITA TNF
6 autosomal dominant deafness-onychodystrophy syndrome 10.2 IFNG TNF
7 distal trisomy 14q 10.2 IFNG TNF
8 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG TNF
9 aniseikonia 10.2 IFNG TNF
10 urethral intrinsic sphincter deficiency 10.2 IFNG TNF
11 plantar wart 10.2 IFNG TNF
12 esophagus lymphoma 10.2 IFNG TNF
13 clostridium difficile colitis 10.2 IFNG TNF
14 parametritis 10.2 IFNG TNF
15 hypotrichosis 4 10.2 IFNG TNF
16 osteodysplasty precocious of danks mayne and kozlowski 10.2 IFNG TNF
17 spastic paraplegia 1 10.2 IFNG TNF
18 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.2 IFNG TNF
19 cyclosporiasis 10.2 IFNG TNF
20 neurotic disorder 10.1 IFNG TNF
21 venezuelan hemorrhagic fever 10.1 IFNG TNF
22 glucose intolerance 10.1 IFNG TNF
23 conduct disorder 10.1 IFNG TNF
24 pancreatic signet ring cell adenocarcinoma 10.1 IFNG TNF
25 pulpitis 10.1 IFNG TNF
26 tularemia 10.1 IFNG TNF
27 hypertropia 10.1 IFNG TNF
28 oral cavity cancer 10.1 IFNG TNF
29 hereditary alpha tryptasemia syndrome 10.1 IFNG TNF
30 hepatitis 10.1 IFNG TNF
31 acute myeloid leukemia with recurrent genetic anomaly 10.1 IFNG TNF
32 erb-duchenne and dejerine-klumpke palsies 10.1 IFNG TNF
33 microcephaly 10.1 IFNG TNF
34 benign deep fibrous histiocytoma 10.1 IFNG TNF
35 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.1 IFNG IGHE
36 abnormal retinal correspondence 10.1 IFNG TNF
37 myofibroma 10.1 IFNG IGHE
38 red cell phospholipid defect with hemolysis 10.1 IFNG TNF
39 strawberry gallbladder 10.1 IFNG TNF
40 plummer's disease 10.1 IFNG TNF
41 isolated klippel-feil syndrome 10.1 IFNG IGHE
42 intussusception 10.1 IL1B TNF
43 hyperinsulinism due to glutamodehydrogenase deficiency 10.1 IFNG IGHE
44 orbital osteomyelitis 10.1 IFNG TNF
45 tau syndrome 10.1 IL1B TNF
46 central nervous system origin vertigo 10.1 IFNG IGHE
47 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 IL1B TNF
48 twin-to-twin transfusion syndrome 10.1 IL1B TNF
49 warthin tumor 10.1 IL1B TNF
50 pericholangitis 10.1 HMGB1 TNF

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to Staphylococcal Toxic Shock Syndrome

Symptoms & Phenotypes for Staphylococcal Toxic Shock Syndrome

Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

Drugs for Staphylococcal Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4 13292-46-1 5458213 5381226
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Pharmaceutical Solutions Phase 4,Phase 2
7 Immunoglobulins Phase 4,Phase 2
8 gamma-Globulins Phase 4,Phase 2
9 Immunoglobulins, Intravenous Phase 4,Phase 2
10 Rho(D) Immune Globulin Phase 4,Phase 2
11 Antibodies Phase 4,Phase 2
12
Imidacloprid Phase 4 105827-78-9 86418
13 Clavulanic Acid Phase 4
14 Clindamycin palmitate Phase 4
15 Clindamycin phosphate Phase 4
16 Amoxicillin-Potassium Clavulanate Combination Phase 4
17 beta-Lactamase Inhibitors Phase 4
18 Antibiotics, Antitubercular Phase 4
19 proline Nutraceutical Phase 4
20 Vaccines Phase 2,Phase 1
21
Aluminum hydroxide Approved Phase 1 21645-51-2
22 Adjuvants, Immunologic Phase 1
23 Gastrointestinal Agents Phase 1
24 Antacids Phase 1
25 Anti-Ulcer Agents Phase 1
26 methicillin

Interventional clinical trials:


id Name Status NCT ID Phase
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4
2 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Recruiting NCT02219165 Phase 2
3 Clinical Trial of the BioMed rTSST‐1 Variant Vaccine in Healthy Adults Recruiting NCT02814708 Phase 2
4 Phase I STEBVax in Healthy Adults Completed NCT00974935 Phase 1
5 Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial Completed NCT02971670 Phase 1
6 rTSST-1 Variant Vaccine Phase 1 First-in-man Trail Completed NCT02340338 Phase 1
7 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

Anatomical Context for Staphylococcal Toxic Shock Syndrome

MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

39
T Cells, Monocytes, B Cells, Testes

Publications for Staphylococcal Toxic Shock Syndrome

Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50) (show all 77)
id Title Authors Year
1
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. ( 27863161 )
2017
2
Acute encephalopathy with biphasic seizures and late reduced diffusion associated with staphylococcal toxic shock syndrome caused by burns. ( 27117386 )
2016
3
Unusual staphylococcal toxic shock syndrome presenting as a scarlet-like fever. ( 26543563 )
2015
4
Staphylococcal toxic shock syndrome caused by tampon use. ( 25692047 )
2015
5
A fatal case of staphylococcal toxic shock syndrome. ( 26265799 )
2015
6
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. ( 24423010 )
2014
7
Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. ( 24816557 )
2014
8
Evidence of Staphylococcal Toxic Shock Syndrome caused by MRSA in a Mother-Newborn Pair. ( 25260039 )
2014
9
Images in clinical medicine. Staphylococcal toxic shock syndrome. ( 23984732 )
2013
10
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. ( 22431984 )
2012
11
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. ( 21860665 )
2011
12
Staphylococcal toxic shock syndrome presenting as acute respiratory distress and cor pulmonale. ( 20196940 )
2010
13
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. ( 21253349 )
2010
14
Staphylococcal toxic shock syndrome: mechanisms and management. ( 21308522 )
2010
15
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. ( 20367234 )
2010
16
Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity. ( 19911998 )
2009
17
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. ( 19402965 )
2009
18
Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vbeta signature in peripheral blood of a 12-year-old boy. ( 18277923 )
2008
19
Staphylococcal toxic shock syndrome. ( 18697637 )
2008
20
Staphylococcal toxic shock syndrome toxin-1 induces the translocation and secretion of high mobility group-1 protein from both activated T cells and monocytes. ( 19009026 )
2008
21
Symmetrical Peripheral Gangrene complicating Staphylococcal Toxic Shock Syndrome. ( 27408131 )
2008
22
Analysis of superantigenic toxin Vbeta T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. ( 18373692 )
2008
23
Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. ( 17409134 )
2007
24
A rare case of staphylococcal toxic shock syndrome after abdominoplasty. ( 19341642 )
2007
25
Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics. ( 16447124 )
2006
26
Reemergence of staphylococcal toxic shock syndrome in the United States since 2000. ( 15815055 )
2005
27
Staphylococcal toxic shock syndrome: still a problem. ( 16116687 )
2005
28
Staphylococcal toxic shock syndrome: still a problem. ( 15963025 )
2005
29
Expansion of TcRalphabeta+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. ( 15034239 )
2004
30
Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. ( 15184497 )
2004
31
Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. ( 15122526 )
2004
32
A 37-year-old man with a febrile illness. Staphylococcal toxic shock syndrome. ( 17171845 )
2003
33
Staphylococcal toxic shock syndrome in a small infant. ( 11938403 )
2002
34
Bacteremic nonmenstrual staphylococcal toxic shock syndrome associated with enterotoxins A and C. ( 11170971 )
2001
35
Postoperative staphylococcal toxic shock syndrome due to pre-existing staphylococcal infection: case report and review of the literature. ( 11510574 )
2001
36
Staphylococcal toxic shock syndrome. Suspicion and prevention are keys to control. ( 11675982 )
2001
37
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. ( 10721486 )
2000
38
Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. ( 10405382 )
1999
39
Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis. ( 10329825 )
1999
40
Interaction of staphylococcal toxic shock syndrome toxin-1 and enterotoxin A on T cell proliferation and TNFI+ secretion in human blood mononuclear cells. ( 22346398 )
1999
41
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. ( 8643591 )
1996
42
Staphylococcal toxic shock syndrome associated with human immunodeficiency virus infection: report of a case with bacteremia. ( 8722964 )
1996
43
Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. ( 8821303 )
1995
44
Staphylococcal toxic shock syndrome in a paediatric burn unit. ( 7880413 )
1994
45
Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1. ( 8253961 )
1993
46
Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. ( 1612731 )
1992
47
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. ( 1639516 )
1992
48
Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. ( 1696937 )
1990
49
Causes of staphylococcal toxic shock syndrome. ( 2380842 )
1990
50
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1. ( 2313089 )
1990

Variations for Staphylococcal Toxic Shock Syndrome

Expression for Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for Staphylococcal Toxic Shock Syndrome

Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CIITA HMGB1 IFNG IGHE IL1B TNF
2
Show member pathways
13.11 CIITA IFNG IGHE IL1B TNF
3
Show member pathways
12.97 HMGB1 IFNG IL1B TNF
4
Show member pathways
12.66 CIITA IFNG IL1B TNF
5
Show member pathways
12.59 CIITA IFNG IL1B TNF
6
Show member pathways
12.51 HMGB1 IFNG IL1B TNF
7
Show member pathways
12.48 IFNG IL1B TNF
8
Show member pathways
12.44 IFNG IGHE TNF
9
Show member pathways
12.4 IFNG IL1B TNF
10
Show member pathways
12.4 IFNG IL1B TNF
11 12.31 CIITA IFNG IL1B TNF
12
Show member pathways
12.26 IFNG IL1B TNF
13
Show member pathways
12.16 IFNG IL1B TNF
14
Show member pathways
12.16 IFNG IL1B TNF
15
Show member pathways
12.11 IFNG IL1B TNF
16
Show member pathways
12.03 IFNG IL1B TNF
17
Show member pathways
12.01 IFNG IL1B TNF
18 11.95 IFNG IL1B TNF
19 11.89 IFNG IL1B TNF
20 11.85 IFNG IL1B TNF
21
Show member pathways
11.83 CIITA IFNG IL1B TNF
22 11.82 IGHE IL1B TNF
23
Show member pathways
11.78 IFNG IL1B TNF
24 11.72 IFNG IL1B TNF
25 11.71 CIITA IFNG IL1B TNF
26
Show member pathways
11.69 IFNG IL1B
27 11.68 IFNG IL1B TNF
28 11.62 IFNG IL1B TNF
29 11.58 IFNG IL1B TNF
30 11.51 IL1B TNF
31
Show member pathways
11.5 IFNG TNF
32 11.47 IFNG TNF
33
Show member pathways
11.47 IFNG IL1B TNF
34 11.45 IL1B TNF
35 11.41 IFNG TNF
36
Show member pathways
11.4 IFNG TNF
37 11.39 IL1B TNF
38 11.37 HMGB1 TNF
39 11.34 IFNG IL1B TNF
40
Show member pathways
11.32 IL1B TNF
41 11.31 IFNG IL1B TNF
42 11.29 IFNG IL1B TNF
43
Show member pathways
11.28 IFNG TNF
44 11.23 IFNG IL1B TNF
45 11.22 IL1B TNF
46 11.16 IL1B TNF
47 11.11 CIITA IFNG IL1B
48 11.06 IFNG IL1B
49 11.04 IFNG IL1B TNF
50 10.99 IL1B TNF

GO Terms for Staphylococcal Toxic Shock Syndrome

Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 HMGB1 IFNG IGHE IL1B TNF
2 external side of plasma membrane GO:0009897 8.8 IFNG IGHE TNF

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 47)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.93 CIITA HMGB1 IFNG TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.89 CIITA IFNG IL1B TNF
3 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.89 CIITA HMGB1 IFNG IL1B TNF
4 positive regulation of gene expression GO:0010628 9.87 IFNG IL1B TNF
5 positive regulation of apoptotic process GO:0043065 9.86 HMGB1 IFNG TNF
6 defense response to bacterium GO:0042742 9.82 IFNG IGHE TNF
7 inflammatory response GO:0006954 9.81 CIITA HMGB1 IL1B TNF
8 positive regulation of protein phosphorylation GO:0001934 9.76 IFNG IL1B TNF
9 positive regulation of T cell proliferation GO:0042102 9.7 IFNG IL1B
10 humoral immune response GO:0006959 9.7 IFNG TNF
11 positive regulation of cell adhesion GO:0045785 9.7 IFNG TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.69 HMGB1 IFNG
13 positive regulation of interferon-gamma production GO:0032729 9.69 IL1B TNF
14 positive regulation of interleukin-6 production GO:0032755 9.68 IL1B TNF
15 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.68 HMGB1 TNF
16 extrinsic apoptotic signaling pathway GO:0097191 9.68 IFNG TNF
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.67 IL1B TNF
18 protein kinase B signaling GO:0043491 9.67 IL1B TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 IL1B TNF
20 positive regulation of phagocytosis GO:0050766 9.66 IL1B TNF
21 protein import into nucleus, translocation GO:0000060 9.66 IFNG TNF
22 positive regulation of interleukin-8 production GO:0032757 9.65 IL1B TNF
23 positive regulation of interleukin-12 production GO:0032735 9.65 HMGB1 IFNG
24 positive regulation of protein complex assembly GO:0031334 9.65 IFNG TNF
25 immune response GO:0006955 9.65 CIITA IFNG IGHE IL1B TNF
26 positive regulation of interleukin-1 beta secretion GO:0050718 9.64 HMGB1 IFNG
27 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 HMGB1 TNF
28 regulation of insulin secretion GO:0050796 9.63 IFNG IL1B TNF
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.62 IL1B TNF
30 positive regulation of osteoclast differentiation GO:0045672 9.62 IFNG TNF
31 positive regulation of interleukin-6 secretion GO:2000778 9.61 HMGB1 IL1B
32 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
33 positive regulation of JNK cascade GO:0046330 9.61 HMGB1 IL1B TNF
34 negative regulation of growth of symbiont in host GO:0044130 9.6 IFNG TNF
35 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL1B TNF
37 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.56 IFNG IL1B
38 regulation of defense response to virus by host GO:0050691 9.55 IFNG IL1B
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 CIITA IFNG
40 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IFNG IL1B TNF
41 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
42 positive regulation of fever generation GO:0031622 9.48 IL1B TNF
43 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
44 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.33 IFNG IL1B TNF
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
46 positive regulation of chemokine biosynthetic process GO:0045080 9.13 IFNG IL1B TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 HMGB1 IFNG IL1B TNF

Sources for Staphylococcal Toxic Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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