MCID: STP004
MIFTS: 34

Staphylococcal Toxic Shock Syndrome malady

Infectious diseases category

Summaries for Staphylococcal Toxic Shock Syndrome

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32MalaCards
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MalaCards: Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and dermatitis. An important gene associated with Staphylococcal Toxic Shock Syndrome is CIITA (class II, major histocompatibility complex, transactivator), and among its related pathways are Type II interferon signaling (IFNG) and Malaria. The compounds hydrocortisone and actinomycin have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

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42NIH Rare Diseases, 48Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
bacterial toxic-shock syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

staphylococcal toxic shock syndrome 42
bacterial toxic-shock syndrome 42 48
staphylococcal toxic-shock syndrome 48
staphylococcal tss 48
bacterial tss 48


External Ids:

ICD10 via Orphanet26 A48.3
SNOMED-CT via Orphanet57 240450004

Related Diseases for Staphylococcal Toxic Shock Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to staphylococcal toxic shock syndrome

Clinical Features for Staphylococcal Toxic Shock Syndrome

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Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Staphylococcal Toxic Shock Syndrome

Drug clinical trials:

Search ClinicalTrials for Staphylococcal Toxic Shock Syndrome

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Search CenterWatch for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

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Anatomical Context for Staphylococcal Toxic Shock Syndrome

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Animal Models for Staphylococcal Toxic Shock Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Staphylococcal Toxic Shock Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.5IGHE, CIITA

Publications for Staphylococcal Toxic Shock Syndrome

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Genetic Variations for Staphylococcal Toxic Shock Syndrome

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Expression for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 52R&D Systems, 12EMD Millipore
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Compounds for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.4IGHE
2actinomycin4410.3IL1B
3gm-csf44 2811.0TNF
4minocycline44 1110.8IL1B, CIITA
5n,n-dimethylsphingosine44 5910.7TNF, IL1B
6tenidap44 2810.7TNF, IL1B
7anakinra44 1110.7IL1B, TNF
8cicaprost44 2810.7TNF, IL1B
9taurine chloramine449.7IL1B, TNF
10vesnarinone449.7TNF, IL1B
11mip 1alpha449.7TNF, IL1B
12gold sodium thiomalate449.7IL1B, TNF
13ro 31 8220449.7IL1B, TNF
145 aminosalicylic acid449.7IL1B, TNF
15il-12449.7IL1B, TNF
16endotoxin449.6CIITA, HMGB1
17staurosporin449.6TNF, IL1B
18tpck449.6TNF, IL1B
19polymyxin b449.6TNF, IL1B
20groalpha449.6IL1B, TNF
21leflunomide49 44 1111.6TNF, IL1B
22triptolide449.5IL1B, TNF
23ciglitazone44 2810.4IL1B, TNF
24sulfasalazine44 28 49 1112.4IL1B, TNF
25lipoteichoic acid449.3IL1B, TNF
26anaphylatoxin449.3HMGB1, IL1B
27etanercept44 49 1111.3TNF, IL1B
28toxin-1449.3TNF, CIITA, IL1B
29polyinosinic-polycytidylic acid449.3CIITA, IL1B, TNF
30peptidoglycan44 2810.3TNF, IL1B, CIITA
31budesonide44 49 1111.3IL1B, TNF, IGHE
32fluticasone propionate44 49 59 1112.3TNF, IGHE, IL1B
33infliximab44 49 1111.2TNF, IGHE, IL1B
34l-nmma449.2TNF, IL1B, IGHE
35rantes449.2TNF, CIITA, IL1B
36ivig449.2TNF, IL1B, IGHE
37ns 39844 5910.2TNF, IL1B
38methotrexate44 49 1111.2IGHE, IL1B, TNF
39n acetylcysteine449.2TNF, IGHE, IL1B
40indomethacin44 59 28 1112.1IGHE, TNF, IL1B
41histamine44 28 2411.1IGHE, TNF, IL1B
42ndga449.0IL1B, TNF
43sp 60012544 599.9TNF, IL1B, HMGB1
44sb 20358044 599.8TNF, HMGB1, IL1B
45actinomycin d448.8TNF, CIITA, IGHE, IL1B
46pd 98,059448.8HMGB1, IL1B, TNF
47cyclosporin a44 28 5910.5TNF, CIITA, HMGB1, IGHE
48nitric oxide44 11 2410.4CIITA, IL1B, HMGB1, TNF
49retinoic acid44 249.3TNF, IGHE, IL1B, HMGB1
50dexamethasone44 49 28 1111.0HMGB1, TNF, CIITA, IGHE, IL1B

GO Terms for genes affiliated with Staphylococcal Toxic Shock Syndrome

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16Gene Ontology
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Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0HMGB1, IL1B, IGHE, TNF

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:0307309.7IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IL1B, TNF
3positive regulation of heterotypic cell-cell adhesionGO:0341169.7IL1B, TNF
4positive regulation of fever generationGO:0316229.7TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IL1B, TNF
8negative regulation of lipid catabolic processGO:0509959.7IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL1B
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
11lipopolysaccharide-mediated signaling pathwayGO:0316639.6IL1B, TNF
12positive regulation of mitosisGO:0458409.6IL1B, TNF
13cellular response to organic cyclic compoundGO:0714079.6TNF, IL1B
14protein kinase B signaling cascadeGO:0434919.6IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.6IL1B, TNF
16positive regulation of interferon-gamma productionGO:0327299.5TNF, IL1B
17positive regulation of interleukin-6 productionGO:0327559.5IL1B, TNF
18positive regulation of JNK cascadeGO:0463309.4TNF, IL1B
19MAPK cascadeGO:0001659.3IL1B, TNF
20regulation of insulin secretionGO:0507969.3IL1B, TNF
21positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.3TNF, HMGB1
22immune responseGO:0069559.2IL1B, IGHE, CIITA
23positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0IL1B, TNF
24positive regulation of transcription, DNA-dependentGO:0458938.9IL1B, CIITA, TNF
25negative regulation of transcription from RNA polymerase II promoterGO:0001228.5TNF, CIITA, HMGB1
26positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TNF, CIITA, IL1B, HMGB1

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5HMGB1, IL1B, TNF

Products for genes affiliated with Staphylococcal Toxic Shock Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Staphylococcal Toxic Shock Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet