MCID: STP004
MIFTS: 39

Staphylococcal Toxic Shock Syndrome malady

Infectious category

Summaries for Staphylococcal Toxic Shock Syndrome

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33MalaCards
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MalaCards: Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and septic shock. An important gene associated with Staphylococcal Toxic Shock Syndrome is CIITA (class II, major histocompatibility complex, transactivator), and among its related pathways are Type II interferon signaling (IFNG) and Malaria. The compounds hydrocortisone and actinomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and t cells, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

Sources:
43NIH Rare Diseases, 49Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
bacterial toxic-shock syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

staphylococcal toxic shock syndrome 43
bacterial toxic-shock syndrome 43 49
staphylococcal toxic-shock syndrome 49
staphylococcal tss 49
bacterial tss 49


External Ids:

ICD10 via Orphanet26 A48.3
SNOMED-CT via Orphanet58 240450004

Related Diseases for Staphylococcal Toxic Shock Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to staphylococcal toxic shock syndrome

Clinical Features for Staphylococcal Toxic Shock Syndrome

Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Staphylococcal Toxic Shock Syndrome

Drug clinical trials:

Search ClinicalTrials for Staphylococcal Toxic Shock Syndrome

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Search CenterWatch for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

Anatomical Context for Staphylococcal Toxic Shock Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

33
Skin, Monocytes, T cells, B cells

Animal Models for Staphylococcal Toxic Shock Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Staphylococcal Toxic Shock Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.5IGHE, CIITA

Publications for Staphylococcal Toxic Shock Syndrome

Sources:
51PubMed
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Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50)    (show all 96)
idTitleAuthorsYear
1
Images in clinical medicine. Staphylococcal toxic shock syndrome. (23984732)
2013
2
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. (22431984)
2012
3
Staphylococcal enterotoxin B toxic shock syndrome induced by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). (23124156)
2012
4
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. (21860665)
2011
5
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. (21253349)
2010
6
Staphylococcal toxic shock syndrome presenting as acute respiratory distress and cor pulmonale. (20196940)
2010
7
Staphylococcal toxic shock syndrome: mechanisms and management. (21308522)
2010
8
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. (19465927)
2009
9
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. (19402965)
2009
10
Specific immuno capturing of the staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma. (19475676)
2009
11
Analysis of superantigenic toxin Vbeta T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. (18373692)
2008
12
Staphylococcal toxic shock syndrome toxin-1 induces the translocation and secretion of high mobility group-1 protein from both activated T cells and monocytes. (19009026)
2008
13
Staphylococcal toxic shock syndrome. (18697637)
2008
14
Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. (17409134)
2007
15
Staphylococcal toxic shock syndrome: still a problem. (16116687)
2005
16
Survey of genes encoding staphylococcal enterotoxins, toxic shock syndrome toxin 1, and exfoliative toxins in members of the Staphylococcus sciuri group. (16145164)
2005
17
Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. (15122526)
2004
18
Expansion of TcRalphabeta+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. (15034239)
2004
19
Concentrations and specific antibodies to staphylococcal enterotoxin-C and toxic shock syndrome toxin-1 in bovine mammary gland secretions, and inflammatory response to the intramammary inoculation of these toxins. (12951423)
2003
20
Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. (11865410)
2002
21
Staphylococcal toxic shock syndrome in a small infant. (11938403)
2002
22
Postoperative staphylococcal toxic shock syndrome due to pre-existing staphylococcal infection: case report and review of the literature. (11510574)
2001
23
Bacteremic nonmenstrual staphylococcal toxic shock syndrome associated with enterotoxins A and C. (11170971)
2001
24
Purified bovine WC1+ gamma delta T lymphocytes are activated by staphylococcal enterotoxins and toxic shock syndrome toxin-1 superantigens: proliferation response, TCR V gamma profile and cytokines expression. (11377702)
2001
25
Survey of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock syndrome toxin 1 gene in non-Staphylococcus aureus species. (11476441)
2001
26
Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody. (10816471)
2000
27
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. (10721486)
2000
28
Staphylococcus aureus isogenic mutant, deficient in toxic shock syndrome toxin-1 but not staphylococcal enterotoxin A production, exhibits attenuated virulence in a tampon-associated vaginal infection model of toxic shock syndrome. (10408098)
1999
29
Co-production of staphylococcal enterotoxin A with toxic shock syndrome toxin-1 (TSST-1) enhances TSST-1 mediated mortality in a D-galactosamine sensitized mouse model of lethal shock. (10458917)
1999
30
Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. (10405382)
1999
31
Insulin regulates IL-1alpha, Ifn-y and IL-4 release from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S. (17657628)
1998
32
Another toxic shock syndrome. Streptococcal infection is even more dangerous than the staphylococcal form. (9861255)
1998
33
Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. (1612731)
1992
34
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1. (2313089)
1990
35
Causes of staphylococcal toxic shock syndrome. (2380842)
1990
36
Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. (1696937)
1990
37
The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. (2584933)
1989
38
Toxicity of staphylococcal toxic shock syndrome toxin 1 for germ-free and conventional piglets. (2928643)
1989
39
Colony immunoblot assay for the detection of staphylococcal toxic shock syndrome toxin 1 (TSST-1) with anti-TSST-1 F(ab')2 fragments. (2778069)
1989
40
Immunohistological localisation of staphylococcal toxic shock syndrome toxin (TSST-1) antigen in sudden infant death syndrome. (2794082)
1989
41
Chick embryo assay for staphylococcal toxic shock syndrome toxin-1. (3231112)
1988
42
Affinity purification of staphylococcal toxic shock syndrome toxin 1 and its pathologic effects in rabbits. (3943896)
1986
43
Outbreak of non-menstrual fatal staphylococcal toxic shock syndrome in India. (2878296)
1986
44
Staphylococcal toxic shock syndrome. (3788008)
1986
45
Clearance of endotoxin from blood of rabbits injected with staphylococcal toxic shock syndrome toxin-1. (3957424)
1986
46
Staphylococcal tracheitis and toxic shock syndrome in a young child. (6481535)
1984
47
Staphylococcal toxic-shock syndrome: mixture of toxins including endotoxin. (6639769)
1983
48
Staphylococcal toxic shock syndrome--an autopsy report. (6668025)
1983
49
Staphylococcal toxic shock syndrome following herniorrhaphy in a male. (6960191)
1982
50
Staphylococcal toxic shock syndrome. (6951568)
1981

Genetic Variations for Staphylococcal Toxic Shock Syndrome

Expression for genes affiliated with Staphylococcal Toxic Shock Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for genes affiliated with Staphylococcal Toxic Shock Syndrome

Sources:
38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 53R&D Systems, 12EMD Millipore
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Compounds for genes affiliated with Staphylococcal Toxic Shock Syndrome

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1hydrocortisone45 2 60 1113.4IGHE
2actinomycin4510.3IL1B
3gm-csf45 2911.0TNF
4minocycline45 1110.8IL1B, CIITA
5n,n-dimethylsphingosine45 6010.7TNF, IL1B
6tenidap45 2910.7TNF, IL1B
7anakinra45 1110.7IL1B, TNF
8cicaprost45 2910.7TNF, IL1B
9taurine chloramine459.7IL1B, TNF
10vesnarinone459.7TNF, IL1B
11mip 1alpha459.7TNF, IL1B
12gold sodium thiomalate459.7IL1B, TNF
13ro 31 8220459.7IL1B, TNF
145 aminosalicylic acid459.7IL1B, TNF
15il-12459.7IL1B, TNF
16endotoxin459.6CIITA, HMGB1
17staurosporin459.6TNF, IL1B
18tpck459.6TNF, IL1B
19polymyxin b459.6TNF, IL1B
20groalpha459.6IL1B, TNF
21leflunomide50 45 1111.6TNF, IL1B
22triptolide459.5IL1B, TNF
23ciglitazone45 2910.4IL1B, TNF
24sulfasalazine45 29 50 1112.4IL1B, TNF
25lipoteichoic acid459.3IL1B, TNF
26anaphylatoxin459.3HMGB1, IL1B
27etanercept45 50 1111.3TNF, IL1B
28toxin-1459.3TNF, CIITA, IL1B
29polyinosinic-polycytidylic acid459.3CIITA, IL1B, TNF
30peptidoglycan45 2910.3TNF, IL1B, CIITA
31budesonide45 50 1111.3IL1B, TNF, IGHE
32fluticasone propionate45 50 60 1112.3TNF, IGHE, IL1B
33infliximab45 50 1111.2TNF, IGHE, IL1B
34l-nmma459.2TNF, IL1B, IGHE
35rantes459.2TNF, CIITA, IL1B
36ivig459.2TNF, IL1B, IGHE
37ns 39845 6010.2TNF, IL1B
38methotrexate45 50 1111.2IGHE, IL1B, TNF
39n acetylcysteine459.2TNF, IGHE, IL1B
40indomethacin45 60 29 1112.1IGHE, TNF, IL1B
41histamine45 29 2411.1IGHE, TNF, IL1B
42ndga459.0IL1B, TNF
43sp 60012545 609.9TNF, IL1B, HMGB1
44sb 20358045 609.8TNF, HMGB1, IL1B
45actinomycin d458.8TNF, CIITA, IGHE, IL1B
46pd 98,059458.8HMGB1, IL1B, TNF
47cyclosporin a45 29 6010.5TNF, CIITA, HMGB1, IGHE
48nitric oxide45 11 2410.4CIITA, IL1B, HMGB1, TNF
49retinoic acid45 249.3TNF, IGHE, IL1B, HMGB1
50dexamethasone45 50 29 1111.0HMGB1, TNF, CIITA, IGHE, IL1B

GO Terms for genes affiliated with Staphylococcal Toxic Shock Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0HMGB1, IL1B, IGHE, TNF

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:0307309.7IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IL1B, TNF
3positive regulation of heterotypic cell-cell adhesionGO:0341169.7IL1B, TNF
4positive regulation of fever generationGO:0316229.7TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IL1B, TNF
8negative regulation of lipid catabolic processGO:0509959.7IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL1B
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
11lipopolysaccharide-mediated signaling pathwayGO:0316639.6IL1B, TNF
12positive regulation of mitosisGO:0458409.6IL1B, TNF
13cellular response to organic cyclic compoundGO:0714079.6TNF, IL1B
14protein kinase B signaling cascadeGO:0434919.6IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.6IL1B, TNF
16positive regulation of interferon-gamma productionGO:0327299.5TNF, IL1B
17positive regulation of interleukin-6 productionGO:0327559.5IL1B, TNF
18positive regulation of JNK cascadeGO:0463309.4TNF, IL1B
19MAPK cascadeGO:0001659.3IL1B, TNF
20regulation of insulin secretionGO:0507969.3IL1B, TNF
21positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.3TNF, HMGB1
22immune responseGO:0069559.2IL1B, IGHE, CIITA
23positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0IL1B, TNF
24positive regulation of transcription, DNA-dependentGO:0458938.9IL1B, CIITA, TNF
25negative regulation of transcription from RNA polymerase II promoterGO:0001228.5TNF, CIITA, HMGB1
26positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TNF, CIITA, IL1B, HMGB1

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5HMGB1, IL1B, TNF

Products for genes affiliated with Staphylococcal Toxic Shock Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Staphylococcal Toxic Shock Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet