MCID: STP004
MIFTS: 36

Staphylococcal Toxic Shock Syndrome malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

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Sources:
45NIH Rare Diseases, 65UMLS, 51Orphanet, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 45 65
Bacterial Toxic-Shock Syndrome 45 51
Staphylococcal Toxic-Shock Syndrome 51
 
Staphylococcal Tss 51
Bacterial Tss 51

Characteristics:

Orphanet epidemiological data:

51
bacterial toxic-shock syndrome:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Orphanet51 36234, 99919
ICD10 via Orphanet28 A48.3
UMLS65 C3714602

Summaries for Staphylococcal Toxic Shock Syndrome

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MalaCards based summary: Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to porphyria and toxic shock syndrome. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways are amb2 Integrin signaling and Pertussis. Affiliated tissues include colon, prostate and heart.

Related Diseases for Staphylococcal Toxic Shock Syndrome

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Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria30.4IL1B, TNF
2toxic shock syndrome11.7
3staphylococcal scarlet fever11.7
4hepatitis10.4
5thyroiditis10.4
6obesity10.3
7hepatitis b10.3
8hypokalemia10.3
9smallpox10.3
10macrophagic myofasciitis10.2HMGB1, TNF
11androgen insensitivity syndrome, mild10.2HMGB1, TNF
12goat milk allergy10.2IGHE, TNF
13hepatoid adenocarcinoma10.2IGHE, TNF
14polycythemia10.2IL1B, TNF
15plantar nerve lesion10.2IL1B, TNF
16peyronie's disease10.2IL1B, TNF
17mammary paget's disease10.2IL1B, TNF
18waardenburg syndrome type 410.2IL1B, TNF
19lujo hemorrhagic fever10.2IL1B, TNF
20residual stage angle-closure glaucoma10.2IL1B, TNF
21testicular granulosa cell tumor10.2IL1B, TNF
22refractory plasma cell neoplasm10.2IL1B, TNF
23skin conditions10.2IL1B, TNF
24postsurgical hypothyroidism10.2IL1B, TNF
25rubeosis iridis10.2IL1B, TNF
26ureteral disease10.2IL1B, TNF
27auricular cancer10.2IL1B, TNF
28duodenum cancer10.2IL1B, TNF
29peripheral retinal degeneration10.2IL1B, TNF
30benign focal amyotrophy10.2IL1B, TNF
31opportunistic bacterial infectious disease10.2IL1B, TNF
32dentin caries10.2IL1B, TNF
33trench fever10.2IL1B, TNF
34placental abruption10.2IL1B, TNF
35secretory diarrhea10.2IL1B, TNF
36meige syndrome10.2IL1B, TNF
37sarcoidosis, early-onset10.2IL1B, TNF
38submandibular gland disease10.2IL1B, TNF
39tracheal stenosis10.2IL1B, TNF
40periodontal disease10.2IL1B, TNF
41blue color blindness10.2IL1B, TNF
42lateral sclerosis10.2IL1B, TNF
43villoglandular variant cervical mucinous adenocarcinoma10.2IL1B, TNF
44acrodysostosis10.1IL1B, TNF
45uterine corpus epithelioid leiomyoma10.1IGHE, TNF
46reflex sympathetic dystrophy10.1IL1B, TNF
47pediatric infratentorial ependymoma10.1IL1B, TNF
48single ventricular heart10.1IL1B, TNF
49chronic cholangitis10.1IL1B, TNF
50neuroblastoma10.1

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to staphylococcal toxic shock syndrome

Symptoms for Staphylococcal Toxic Shock Syndrome

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Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

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Drugs for Staphylococcal Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunologic FactorsPhase 2, Phase 118483
2Pharmaceutical SolutionsPhase 27004
3Rho(D) Immune GlobulinPhase 2206
4Immunoglobulins, IntravenousPhase 2211
5ImmunoglobulinsPhase 24477
6AntibodiesPhase 24477
7
Aluminum hydroxideapprovedPhase 1178
Synonyms:
Al(OH)3
Aluminiumhydroxid
 
Aluminum Hydroxide
Aluminum hydroxide
Dermadrox
8VaccinesPhase 16085
9Adjuvants, ImmunologicPhase 11783
10Gastrointestinal AgentsPhase 16401
11Anti-Ulcer AgentsPhase 11453
12AntacidsPhase 11453
13methicillin148
14Anti-Bacterial Agents9140
15Anti-Infective Agents17220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot StudyRecruitingNCT02219165Phase 2
2Phase I STEBVax in Healthy AdultsCompletedNCT00974935Phase 1
3rTSST-1 Variant Vaccine Phase 1CompletedNCT02340338Phase 1
4Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus AureusCompletedNCT01141101

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

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Anatomical Context for Staphylococcal Toxic Shock Syndrome

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MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

33
Colon, Prostate, Heart, Endothelial, B cells, T cells, Testes

Animal Models for Staphylococcal Toxic Shock Syndrome or affiliated genes

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Publications for Staphylococcal Toxic Shock Syndrome

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Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Severe First Trimester Recurrent Intrahepatic Cholestasis of Pregnancy: A Case Report and Literature Review. (26929868)
2016
2
Salivary gland adenoid cystic carcinoma. (26214665)
2015
3
Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults. (26354538)
2015
4
S267P Mutation in FGFR2: First Report in a Patient With Crouzon Syndrome. (25759927)
2015
5
Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1. (25749978)
2015
6
Hypoplastic left heart syndrome secondary to intrauterine rhabdomyoma necessitating single ventricle palliation. (25298697)
2014
7
Expression of multidrug resistance-associated protein 2 in human gallbladder carcinoma. (23841074)
2013
8
Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection. (23680261)
2013
9
Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection. (22184725)
2012
10
H2O2-dependent translocation of TCTP into the nucleus enables its interaction with VDR in human keratinocytes: TCTP as a further module in calcitriol signalling. (19815065)
2010
11
Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells. (19734935)
2009
12
Early production of gamma-interferon in clinical malaria: role of interleukin-18 and interleukin-12. (19374561)
2009
13
Electroacupuncture relieves pain in men with chronic prostatitis/chronic pelvic pain syndrome: three-arm randomized trial. (19394499)
2009
14
Dental fluorosis: exposure, prevention and management. (19179949)
2009
15
Myostatin and muscle fiber size. Focus on "Smad2 and 3 transcription factors control muscle mass in adulthood" and "Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size". (19357232)
2009
16
Malignant glomus tumor arising among multiple glomus tumors. (18843464)
2008
17
A new mutation in the human pres gene and its effect on prestin function. (17786286)
2007
18
Retinally-induced aniseikonia. (17688418)
2007
19
Multidrug-resistant tuberculosis in Mumbai: it's only getting worse. (17171830)
2006
20
Arteriosclerotic events are less frequent in persons with chronic anemia: evidence from families with hereditary spherocytosis. (16628733)
2006
21
Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways. (16877565)
2006
22
Autosomal dominant congenital golden crystal nuclear cataract caused by a missense mutation in gammaD crystallin gene (CRYGD) in a Chinese family]. (17217786)
2006
23
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (16004602)
2005
24
Comparing antigenicity and immunogenicity of engineered gp120. (16160142)
2005
25
SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA. (16116489)
2005
26
Primary hyperparathyroidism and neuropsychiatric alterations in a nonagenarian woman. (15847125)
2005
27
Spinal gap junctions: potential involvement in pain facilitation. (15501197)
2004
28
Impact of multislice CT on coronary ostial stenosis in Takayasu's arteritis. (14729775)
2004
29
Clinical characteristics and outcomes of surgical patients with vancomycin-resistant enterococcal infections. (12852510)
2003
30
Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients. (12472798)
2003
31
Rapid changes of flow-mediated dilatation after surgical menopause. (12590008)
2003
32
Blood pressure and endocrine responses of healthy subjects in cold pressor test after acutely increased dietary sodium intake. (11499168)
2001
33
Legg-CalvAc-Perthes disease: MR imaging evaluation during manual positioning of the hip--comparison with conventional arthrography. (10429712)
1999
34
Complications and technical limitations of hepatic arterial infusion catheter placement for chemotherapy. (9540905)
1998
35
The bovine thromboxane A2 receptor: molecular cloning, expression, and functional characterization. (9459567)
1998
36
Frank haematuria during pregnancy due to placenta praevia percreta. (9158533)
1997
37
Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin. (9354432)
1997
38
Intracellular distribution of an integral nuclear pore membrane protein fused to green fluorescent protein--localization of a targeting domain. (9461306)
1997
39
Pityriasis lichenoides chronica in association with Tubercular Lymphadenitis. (20944365)
1997
40
HDL, its enzymes and its potential to influence lipid peroxidation. (7661883)
1995
41
Multiplane transesophageal echocardiographic evaluation of mitral valve disease. (7795376)
1995
42
Distribution of S-100 protein-positive dendritic cells inside the cancer nest and expression of HLA-DR antigen and blood group antigen on the cancer cell in transitional cell carcinoma of the urinary bladder--in relation to tumor progression and prognosis]. (8170082)
1994
43
Use of radiolabeled somatostatin analogs in the identification and treatment of somatostatin receptor-bearing tumors. (8359574)
1993
44
Staged repair improves outcome of high-risk premature infants with esophageal atresia and tracheoesophageal fistula. (8437067)
1993
45
Significance of both numerical and structural chromosomal abnormalities in clear cell sarcoma. (1486557)
1992
46
Dentin-dentinal adhesive interaction. Calorimetric measurement]. (2118459)
1990
47
Spinal cord compression associated with pseudohypoparathyroidism. (2304055)
1990
48
Current views on the pathogenesis of bacterial endometritis in mares. (2683335)
1989
49
Pulmonary eosinophilia. (890359)
1977
50
Paraquat poisoning.---Report of a survivor. (1025043)
1976

Variations for Staphylococcal Toxic Shock Syndrome

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Expression for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
19.5HMGB1, TNF
29.4IL1B, TNF
39.4IL1B, TNF
49.4IL1B, TNF
59.4IL1B, TNF
69.4IL1B, TNF
7
Show member pathways
9.4IL1B, TNF
89.4IL1B, TNF
99.4IL1B, TNF
109.4IL1B, TNF
119.4IL1B, TNF
129.4IL1B, TNF
139.4IL1B, TNF
149.4IL1B, TNF
159.4IL1B, TNF
169.4IL1B, TNF
179.4IL1B, TNF
18
Show member pathways
9.4IL1B, TNF
199.0CIITA, IL1B
20
Show member pathways
8.9HMGB1, IL1B, TNF
21
Show member pathways
8.6CIITA, IL1B, TNF
22
Show member pathways
8.6CIITA, IL1B, TNF
238.6CIITA, IL1B, TNF
24
Show member pathways
8.6CIITA, IL1B, TNF
25
Show member pathways
7.5CIITA, HMGB1, IGHE, IL1B, TNF

GO Terms for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328010.1HMGB1, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.1IL1B, TNF
3positive regulation of membrane protein ectodomain proteolysisGO:005104410.1IL1B, TNF
4sequestering of triglycerideGO:003073010.1IL1B, TNF
5regulation of establishment of endothelial barrierGO:190314010.1IL1B, TNF
6positive regulation of chemokine biosynthetic processGO:004508010.1IL1B, TNF
7positive regulation of NF-kappaB import into nucleusGO:004234610.1IL1B, TNF
8positive regulation of nitric oxide biosynthetic processGO:004542910.0IL1B, TNF
9positive regulation of fever generationGO:003162210.0IL1B, TNF
10positive regulation of interleukin-6 secretionGO:200077810.0HMGB1, IL1B
11negative regulation of lipid catabolic processGO:005099510.0IL1B, TNF
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1B, TNF
13regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
14positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9IL1B, TNF
15positive regulation of interferon-gamma productionGO:00327299.9IL1B, TNF
16activation of MAPK activityGO:00001879.9IL1B, TNF
17positive regulation of phagocytosisGO:00507669.8IL1B, TNF
18regulation of insulin secretionGO:00507969.8IL1B, TNF
19positive regulation of JNK cascadeGO:00463309.7HMGB1, IL1B
20positive regulation of ERK1 and ERK2 cascadeGO:00703749.7HMGB1, IL1B
21positive regulation of apoptotic processGO:00430659.7IL1B, TNF
22positive regulation of NF-kappaB transcription factor activityGO:00510929.7IL1B, TNF
23negative regulation of gene expressionGO:00106299.6IL1B, TNF
24leukocyte migrationGO:00509009.5IL1B, TNF
25cellular response to lipopolysaccharideGO:00712229.5IL1B, TNF
26response to glucocorticoidGO:00513849.4HMGB1, IL1B, TNF
27positive regulation of JUN kinase activityGO:00435079.4IL1B, TNF
28defense response to bacteriumGO:00427429.4IGHE, TNF
29agingGO:00075689.4CIITA, IL1B
30positive regulation of protein phosphorylationGO:00019349.2HMGB1, IL1B, TNF
31positive regulation of interleukin-6 productionGO:00327559.2HMGB1, IL1B, TNF
32positive regulation of transcription, DNA-templatedGO:00458939.0CIITA, IL1B, TNF
33inflammatory responseGO:00069548.8CIITA, IL1B, TNF
34negative regulation of transcription from RNA polymerase II promoterGO:00001228.2CIITA, HMGB1, IL1B, TNF
35positive regulation of transcription from RNA polymerase II promoterGO:00459448.1CIITA, HMGB1, IL1B, TNF

Sources for Staphylococcal Toxic Shock Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet