MCID: STP004
MIFTS: 46

Staphylococcal Toxic Shock Syndrome malady

Rare diseases, Infectious diseases categories

Summaries for Staphylococcal Toxic Shock Syndrome

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MalaCards: Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and atopic dermatitis. An important gene associated with Staphylococcal Toxic Shock Syndrome is CIITA (class II, major histocompatibility complex, transactivator), and among its related pathways are TRAF Pathway and Type II interferon signaling (IFNG). The compounds minocycline and n,n-dimethylsphingosine have been mentioned in the context of this disorder. Affiliated tissues include monocytes, t cells and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

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44NIH Rare Diseases, 50Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
bacterial toxic-shock syndrome:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

staphylococcal toxic shock syndrome 44
bacterial toxic-shock syndrome 44 50
staphylococcal toxic-shock syndrome 50
staphylococcal tss 50
bacterial tss 50


External Ids:

ICD10 via Orphanet27 A48.3
SNOMED-CT via Orphanet60 240450004

Related Diseases for Staphylococcal Toxic Shock Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1toxic shock syndrome31.8IL1B, CIITA, TNF
2atopic dermatitis30.4TNF, IGHE
3septic shock30.3HMGB1, IL1B, CIITA, TNF
4burns10.3
5scarlet fever10.3
6sudden infant death syndrome10.3
7wegener's granulomatosis10.3
8aspergillosis10.3
9dermatitis10.3
10bacteremia10.3
11cor pulmonale10.3
12staphylococcal scarlet fever10.3
13ocular cicatricial pemphigoid10.1CIITA
14degenerative disc disease10.1IL1B
15skin disease10.1IL1B
16malaria10.0HMGB1, TNF
17blau syndrome10.0IL1B, TNF
18aids dementia complex10.0TNF, IL1B
19familial mediterranean fever10.0IL1B, TNF
20chorioamnionitis10.0IL1B, TNF
21arthritis10.0IL1B, TNF
22encephalomyelitis10.0TNF, CIITA
23rheumatic disease10.0TNF, HMGB1
24interstitial lung disease10.0TNF, IL1B
25psoriatic arthritis10.0TNF, IL1B
26cerebral malaria10.0TNF, IL1B
27respiratory failure10.0IL1B, TNF
28newborn respiratory distress syndrome10.0HMGB1, IL1B
29hepatitis c10.0CIITA, TNF
30peritonitis10.0TNF, IL1B
31periodontitis10.0TNF, IL1B
32arthropathy10.0IL1B, TNF
33monocytic leukemia10.0TNF, IL1B
34periodontal disease10.0TNF, IL1B
35hypersensitivity reaction type ii disease10.0IL1B, TNF
36galactosemia10.0IL1B, TNF
37bullous pemphigoid10.0IGHE, CIITA
38sarcoidosis10.0IL1B, TNF
39schistosomiasis10.0HMGB1, IGHE
40primary hyperoxaluria10.0IL1B, TNF
41congenital heart disease10.0IL1B, TNF
42otitis media10.0IGHE, IL1B
43encephalitis10.0CIITA, IL1B, HMGB1
44inflammatory bowel disease10.0IL1B, CIITA, TNF
45type 1 diabetes mellitus10.0CIITA, IL1B
46tuberculosis10.0TNF, CIITA, IL1B
47adult respiratory distress syndrome10.0HMGB1, IL1B, TNF
48synovitis10.0TNF, IL1B, HMGB1
49psoriasis10.0TNF, CIITA, IL1B
50multiple sclerosis10.0IL1B, CIITA, TNF

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to staphylococcal toxic shock syndrome

Symptoms for Staphylococcal Toxic Shock Syndrome

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Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Staphylococcal Toxic Shock Syndrome

Drug clinical trials:

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Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

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Genetic Tests for Staphylococcal Toxic Shock Syndrome

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Anatomical Context for Staphylococcal Toxic Shock Syndrome

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34MalaCards
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MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

34
Monocytes, T cells, B cells, Testes

Animal Models for Staphylococcal Toxic Shock Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Staphylococcal Toxic Shock Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4IL1B, CIITA, TNF, IGHE
2MP:00053978.1IGHE, TNF, CIITA, IL1B
3MP:00053767.4HMGB1, IL1B, CIITA, TNF, IGHE

Publications for Staphylococcal Toxic Shock Syndrome

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53PubMed
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Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. (24423010)
2014
2
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. (22431984)
2012
3
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. (21860665)
2011
4
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. (20367234)
2010
5
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. (21253349)
2010
6
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. (19402965)
2009
7
Analysis of superantigenic toxin Vbeta T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock. (18373692)
2008
8
Staphylococcal toxic shock syndrome toxin-1 induces the translocation and secretion of high mobility group-1 protein from both activated T cells and monocytes. (19009026)
2008
9
A rare case of staphylococcal toxic shock syndrome after abdominoplasty. (19341642)
2007
10
Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. (17409134)
2007
11
Staphylococcal toxic shock syndrome: still a problem. (16116687)
2005
12
Staphylococcal toxic shock syndrome: still a problem. (15963025)
2005
13
Reemergence of staphylococcal toxic shock syndrome in the United States since 2000. (15815055)
2005
14
Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. (15122526)
2004
15
Expansion of TcRalphabeta+CD3+CD4-CD8- (CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. (15034239)
2004
16
Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. (15184497)
2004
17
A 37-year-old man with a febrile illness. Staphylococcal toxic shock syndrome. (17171845)
2003
18
Staphylococcal toxic shock syndrome in a small infant. (11938403)
2002
19
Postoperative staphylococcal toxic shock syndrome due to pre-existing staphylococcal infection: case report and review of the literature. (11510574)
2001
20
Bacteremic nonmenstrual staphylococcal toxic shock syndrome associated with enterotoxins A and C. (11170971)
2001
21
Staphylococcal toxic shock syndrome. Suspicion and prevention are keys to control. (11675982)
2001
22
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. (10721486)
2000
23
Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. (10405382)
1999
24
Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis. (10329825)
1999
25
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. (8643591)
1996
26
Staphylococcal toxic shock syndrome associated with human immunodeficiency virus infection: report of a case with bacteremia. (8722964)
1996
27
Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. (8821303)
1995
28
Staphylococcal toxic shock syndrome in a paediatric burn unit. (7880413)
1994
29
Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1. (8253961)
1993
30
Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. (1612731)
1992
31
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. (1639516)
1992
32
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1. (2313089)
1990
33
Causes of staphylococcal toxic shock syndrome. (2380842)
1990
34
Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. (1696937)
1990
35
Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria. (2928649)
1989
36
Chick embryo assay for staphylococcal toxic shock syndrome toxin-1. (3231112)
1988
37
Detection of staphylococcal toxic shock syndrome toxin 1 by a latex agglutination kit. (3194712)
1988
38
Comparison of two newly developed forms of an enzyme-linked immunosorbent assay for the detection of staphylococcal toxic shock syndrome toxin-1 (TSST-1). (3447385)
1987
39
Affinity purification of staphylococcal toxic shock syndrome toxin 1 and its pathologic effects in rabbits. (3943896)
1986
40
Outbreak of non-menstrual fatal staphylococcal toxic shock syndrome in India. (2878296)
1986
41
Latex agglutination test for staphylococcal toxic shock syndrome toxin 1. (3082921)
1986
42
Regulation of staphylococcal toxic shock syndrome toxin-1 and total exoprotein production by magnesium ion. (3527988)
1986
43
Staphylococcal toxic shock syndrome. (3788008)
1986
44
Disseminated aspergillosis in a patient with staphylococcal toxic shock syndrome. (3748246)
1986
45
Staphylococcal toxic-shock syndrome: mixture of toxins including endotoxin. (6639769)
1983
46
Varicella zoster and staphylococcal toxic shock syndrome in a young man. (6218314)
1983
47
Staphylococcal toxic shock syndrome--an autopsy report. (6668025)
1983
48
Staphylococcal toxic shock syndrome following herniorrhaphy in a male. (6960191)
1982
49
Risk factors for staphylococcal toxic-shock syndrome. (7315834)
1981
50
Renal manifestations of the staphylococcal toxic-shock syndrome. (7282746)
1981

Variations for Staphylococcal Toxic Shock Syndrome

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Expression for genes affiliated with Staphylococcal Toxic Shock Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology, 56Reactome, 61Thomson Reuters, 55R&D Systems
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Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9TNF
29.5IL1B, CIITA
39.3TNF, IL1B
49.3IL1B, TNF
5
Show member pathways
9.3TNF, IL1B
6
Show member pathways
Immune response MIF in innate immunity response61
9.3IL1B, TNF
7
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.3IL1B, TNF
89.3TNF, IL1B
99.3TNF, IL1B
109.3IL1B, TNF
11
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.3TNF, IL1B
12
Show member pathways
9.3IL1B, TNF
139.3IL1B, TNF
149.3IL1B, TNF
15
Show member pathways
9.3TNF, IL1B
16
Show member pathways
thioredoxin pathway39
9.3TNF, IL1B
179.3TNF, IL1B
189.3IL1B, TNF
199.3IL1B, TNF
209.3TNF, IL1B
219.3IL1B, TNF
22
Show member pathways
Serotonin Transporter Activity39
9.3TNF, IL1B
239.3TNF, IL1B
249.3IL1B, TNF
259.3IL1B, TNF
269.3IL1B, TNF
27
Show member pathways
IL27-mediated signaling events39
9.3TNF, IL1B
289.3TNF, IL1B
299.3TNF, IL1B
309.3IL1B, TNF
319.3IL1B, TNF
32
Show member pathways
9.1HMGB1, IL1B
33
Show member pathways
9.0TNF, HMGB1
349.0TNF, HMGB1
358.9IL1B, CIITA, TNF
36
Show member pathways
8.9IL1B, CIITA, TNF
37
Show member pathways
8.9TNF, CIITA, IL1B
38
Show member pathways
8.9TNF, CIITA, IL1B
39
Show member pathways
8.5HMGB1, IL1B, TNF

Compounds for genes affiliated with Staphylococcal Toxic Shock Syndrome

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 3BitterDB, 25HMDB
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Compounds related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1minocycline46 1210.8CIITA, IL1B
2n,n-dimethylsphingosine46 6210.7TNF, IL1B
3tenidap46 3010.7TNF, IL1B
4anakinra46 1210.7IL1B, TNF
5cicaprost46 3010.7IL1B, TNF
6vesnarinone469.7TNF, IL1B
7taurine chloramine469.7TNF, IL1B
8mip 1alpha469.7TNF, IL1B
9actinomycin469.7TNF, IL1B
10gold sodium thiomalate469.7TNF, IL1B
11ro 31 8220469.7IL1B, TNF
12il-12469.7IL1B, TNF
135 aminosalicylic acid469.6IL1B, TNF
14staurosporin469.6IL1B, TNF
15tpck469.6IL1B, TNF
16polymyxin b469.6IL1B, TNF
17leflunomide46 52 1211.6IL1B, TNF
18groalpha469.5IL1B, TNF
19triptolide469.5IL1B, TNF
20gm-csf46 3010.4IL1B, TNF
21ciglitazone46 3010.4IL1B, TNF
22sulfasalazine30 46 52 1212.3TNF, IL1B
23ns 39846 6210.3IL1B, TNF
24toxin-1469.3IL1B, CIITA, TNF
25polyinosinic-polycytidylic acid469.3IL1B, CIITA, TNF
26anaphylatoxin469.3IL1B, HMGB1
27peptidoglycan46 3010.3TNF, CIITA, IL1B
28budesonide46 52 1211.3IL1B, TNF, IGHE
29fluticasone propionate46 52 62 1212.3IGHE, TNF, IL1B
30l-nmma469.2IL1B, TNF, IGHE
31infliximab46 52 1211.2IL1B, TNF, IGHE
32rantes469.2IL1B, CIITA, TNF
33ivig469.2IL1B, TNF, IGHE
34lipoteichoic acid469.2TNF, IL1B
35hydrocortisone46 3 62 1212.2IGHE, TNF, IL1B
36methotrexate52 46 1211.2IL1B, TNF, IGHE
37n acetylcysteine469.2IL1B, TNF, IGHE
38indomethacin46 30 62 1212.1IGHE, TNF, IL1B
39histamine46 30 2511.1IL1B, TNF, IGHE
40sp 60012546 629.9HMGB1, IL1B, TNF
41sb 20358046 629.8HMGB1, IL1B, TNF
42actinomycin d468.8IGHE, TNF, CIITA, IL1B
43cycloheximide468.8IGHE, TNF, CIITA, IL1B
44pd 98,059468.8TNF, IL1B, HMGB1
45pge2468.6IL1B, CIITA, TNF
46endotoxin468.5HMGB1, IL1B, CIITA, TNF
47cyclosporin a46 30 6210.5IGHE, TNF, CIITA, HMGB1
48nitric oxide46 25 1210.5HMGB1, IL1B, CIITA, TNF
49retinoic acid46 259.4IGHE, TNF, IL1B, HMGB1
50dexamethasone46 52 30 1211.0IGHE, TNF, CIITA, IL1B, HMGB1

GO Terms for genes affiliated with Staphylococcal Toxic Shock Syndrome

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17Gene Ontology
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Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5HMGB1, IL1B, TNF
2cell surfaceGO:0099868.5HMGB1, CIITA, TNF
3extracellular regionGO:0055767.7IGHE, TNF, IL1B, HMGB1

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:0307309.7IL1B, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IL1B, TNF
3positive regulation of fever generationGO:0316229.7IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:0341169.7IL1B, TNF
5positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IL1B
6regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.7IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IL1B
8negative regulation of lipid catabolic processGO:0509959.7IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:0423469.7IL1B, TNF
10lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, IL1B
11positive regulation of mitosisGO:0458409.7IL1B, TNF
12positive regulation of nitric oxide biosynthetic processGO:0454299.7TNF, IL1B
13protein kinase B signalingGO:0434919.6TNF, IL1B
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
15cellular response to organic cyclic compoundGO:0714079.6IL1B, TNF
16positive regulation of interferon-gamma productionGO:0327299.6TNF, IL1B
17positive regulation of interleukin-6 productionGO:0327559.6IL1B, TNF
18positive regulation of JNK cascadeGO:0463309.6IL1B, TNF
19MAPK cascadeGO:0001659.5TNF, IL1B
20regulation of insulin secretionGO:0507969.4IL1B, TNF
21positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4TNF, IL1B
22activation of MAPK activityGO:0001879.3TNF, IL1B
23positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3IL1B, TNF
24positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.3TNF, HMGB1
25immune responseGO:0069559.3IL1B, CIITA, IGHE
26positive regulation of protein phosphorylationGO:0019349.2IL1B, TNF
27inflammatory responseGO:0069549.2IL1B, CIITA, TNF
28positive regulation of transcription, DNA-templatedGO:0458939.1TNF, CIITA, IL1B
29positive regulation of NF-kappaB transcription factor activityGO:0510929.0IL1B, TNF
30negative regulation of transcription from RNA polymerase II promoterGO:0001228.8TNF, CIITA, HMGB1
31apoptotic processGO:0069158.7HMGB1, IL1B, TNF
32positive regulation of transcription from RNA polymerase II promoterGO:0459448.4HMGB1, IL1B, CIITA, TNF

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5HMGB1, IL1B, TNF

Products for genes affiliated with Staphylococcal Toxic Shock Syndrome

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Sources for Staphylococcal Toxic Shock Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet