MCID: STT001
MIFTS: 56

Status Epilepticus malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Status Epilepticus

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Status Epilepticus, Aliases & Descriptions:

Name: Status Epilepticus 9 41 43 60
Generalized Convulsive Status Epilepticus 41
Grand Mal Status Epilepticus 60
 
Grand Mal Status 9
Gcse 41
Se 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:1824
NCIt38 C85079
MeSH33 D013226
ICD1025 G41, C84.1, G41.0

Summaries for Status Epilepticus

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Wikipedia:63 Status epilepticus (SE) is an epileptic seizure of greater than five minutes or more than one seizure... more...

MalaCards based summary: Status Epilepticus, also known as generalized convulsive status epilepticus, is related to encephalitis and temporal lobe epilepsy. An important gene associated with Status Epilepticus is POLG (polymerase (DNA directed), gamma), and among its related pathways are Glutamic acid signaling and Circadian entrainment. The drugs diazepam and etomidate and the compounds dnqx and axokine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related mouse phenotypes are taste/olfaction and reproductive system.

Related Diseases for Status Epilepticus

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Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 662)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis31.5CNR1
2temporal lobe epilepsy30.8BDNF, NPY, GAD1
3cholera30.1CNR1, GAP43, GAD1
4herpes simplex30.1GAP43, BDNF, GAD1, POLG
5hypoglycemia29.7GAD1, BDNF, POLG, NPY
6bipolar disorder29.6BDNF, GAP43, GAD1, POLG, CNR1
7hyperglycemia29.4NPY, GAD1, JUN, BDNF
8schizophrenia29.2CNR1, GRIA2, BDNF, NPY, GAP43, GAD1
9epilepsy syndrome28.6GAP43, BDNF, NPY, GAD1, GRIA2, CNR1
10neuronitis10.8
11neurosyphilis10.6
12cerebritis10.5
13norse10.5
14limbic encephalitis10.4
15cat-scratch disease10.4
16febrile infection-related epilepsy syndrome10.4
17dravet syndrome10.3
18brain injury10.3
19hepatitis10.3
20cadasil10.3
21focal epilepsy10.3
22ring chromosome 2010.3
23epilepsy, pyridoxine-dependent10.3
24lennox-gastaut syndrome10.3
25porphyria10.3
26polymicrogyria10.3
27blindness10.3
28landau-kleffner syndrome10.2
29cortical blindness10.2
30melas syndrome10.2
31hepatic encephalopathy10.2
32meningitis10.2
33autoimmune encephalitis10.2
34hemimegalencephaly10.2
35herpes simplex encephalitis10.2
36anoxia10.2
37myoclonus10.2
38major depressive disorder and accelerated response to antidepressant drug treatment10.2BDNF, GAD1
39central nervous system disease10.2CNR1, BDNF
40motor neuron disease10.2GRIA2, BDNF
41autonomic neuropathy10.1GAD1, NPY
42schizencephaly10.1
43amish infantile epilepsy syndrome10.1
44crigler-najjar syndrome, type i10.1
45thanatophoric dysplasia, type i10.1
46succinic semialdehyde dehydrogenase deficiency10.1
47argininemia10.1
48central hypoventilation syndrome, congenital10.1
49l-2-hydroxyglutaric aciduria10.1
50angelman syndrome10.1

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to status epilepticus

Symptoms for Status Epilepticus

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Drugs & Therapeutics for Status Epilepticus

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Genetic Tests for Status Epilepticus

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Anatomical Context for Status Epilepticus

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MalaCards organs/tissues related to Status Epilepticus:

31
Brain, Temporal lobe, Cortex, Amygdala, Bone marrow, Bone, Endothelial, Cerebellum, Heart, Lung, Thyroid, Breast, Skin, Monocytes, Thalamus, Pituitary, Neutrophil

Animal Models for Status Epilepticus or affiliated genes

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MGI Mouse Phenotypes related to Status Epilepticus:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2BDNF, GAD1, CNR1
2MP:00053898.4BDNF, GRIA2, CNR1, POLG, DCX
3MP:00053818.3POLG, CNR1, GAD1, NPY, BDNF
4MP:00053907.8POLG, JUN, CNR1, GAD1, NPY
5MP:00107717.8POLG, JUN, CNR1, GRIA2, BDNF
6MP:00028737.5JUN, CNR1, GRIA2, GAD1, NPY, BDNF
7MP:00053847.4POLG, JUN, CNR1, GRIA2, GAD1, GAP43
8MP:00030127.4DCX, POLG, JUN, CNR1, GRIA2, GAD1
9MP:00053767.2POLG, JUN, CNR1, GRIA2, GAD1, NPY
10MP:00053867.1DCX, JUN, CNR1, GRIA2, GAD1, NPY
11MP:00107686.9DCX, POLG, JUN, CNR1, GRIA2, GAD1
12MP:00036316.3BDNF, DCX, POLG, JUN, CNR1, GRIA2
13MP:00053786.3DCX, POLG, JUN, CNR1, GRIA2, GAD1

Publications for Status Epilepticus

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Articles related to Status Epilepticus:

(show top 50)    (show all 738)
idTitleAuthorsYear
1
Peroxisome proliferatora89activated receptora89I^ agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus. (25891824)
2015
2
Predictors of Outcome of Convulsive Status Epilepticus Among an Egyptian Pediatric Tertiary Hospital. (25895912)
2015
3
Syndromes at risk of status epilepticus in children: genetic and pathophysiological issues. (25323303)
2014
4
Attitude of epilepsy patients and their attendants for participating in research on status epilepticus. (25376558)
2014
5
A girl with Cardio-facio-cutaneous syndrome complicated with status epilepticus and acute encephalopathy. (23340054)
2014
6
Outcome of status epilepticus. What do we learn from animal data? (25322806)
2014
7
Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy? (23266599)
2013
8
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
9
Ginseng extract attenuates early MRI changes after status epilepticus and decreases subsequent reduction of hippocampal volume in the rat brain. (24359691)
2013
10
Propofol versus thiopental sodium for the treatment of refractory status epilepticus (Review). (23877948)
2013
11
Good functional outcome after prolonged postanoxic comatose myoclonic status epilepticus in a patient who had undergone bone marrow transplantation. (24368951)
2013
12
Adjunctive enteral phenobarbital for adult status epilepticus: a brief report. (24379674)
2013
13
Primary antiphospholipid syndrome manifesting as partial status epilepticus. (23545615)
2013
14
The multifaceted care of status epilepticus. (24001076)
2013
15
Usefulness of intravenous lacosamide in status epilepticus. (24122063)
2013
16
Turning up the heat on the impact of febrile status epilepticus. (23447728)
2013
17
Subclinical epileptiform activity in children with electrical status epilepticus during sleep: effects on cognition and behavior before and after treatment with levetiracetam. (23376335)
2013
18
Analysis of the delay components in the treatment of status epilepticus. (23817962)
2013
19
Effect of the calcineurin inhibitor FK506 on K+-Cl- cotransporter 2 expression in the mouse hippocampus after kainic acid-induced status epilepticus. (22160488)
2012
20
Early appearance of diffusion-weighted hyperintensities in aphasic status epilepticus. A case report. (24028874)
2012
21
Frequency of non-convulsive seizures and non-convulsive status epilepticus in subarachnoid hemorrhage patients in need of controlled ventilation and sedation. (22932991)
2012
22
Sporadic Creutzfeldt-Jakob disease in a patient with episodes of nonconvulsive status epilepticus: case report. (22920008)
2012
23
Persistent decrease in multiple components of the perineuronal net following status epilepticus. (22934955)
2012
24
Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. (22591751)
2012
25
Guidelines for status epilepticus: are we there yet? (22696014)
2012
26
Deep hypothermia terminates status epilepticus--an experimental study. (22365745)
2012
27
The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. (22577217)
2012
28
Pupillary hippus in nonconvulsive status epilepticus. (22940244)
2012
29
Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). (22509732)
2012
30
Cognitive outcome of status epilepticus in children. (22957250)
2012
31
Non-convulsive status epilepticus in comatose patients (case reports). (22859443)
2012
32
A case of central cord syndrome related status epilepticus - a case report -. (22506176)
2011
33
Mild hypothermia for refractory focal status epilepticus in an infant with hemimegalencephaly. (20060761)
2010
34
Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. (18294203)
2008
35
Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury induction. (18511210)
2008
36
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. (17630998)
2007
37
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
38
Advances in the pathophysiology of status epilepticus. (17784531)
2007
39
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
40
Age-related electrical status epilepticus during sleep and epileptic negative myoclonus in DRPLA. (16534126)
2006
41
Altered expression of GABA(A) and GABA(B) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. (15951123)
2005
42
Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: induced abortion as the sole therapeutic option? (15469454)
2004
43
Landau-Kleffner syndrome, electrical status epilepticus in slow wave sleep, and language regression in children. (15362173)
2004
44
Transient Kluver-Bucy syndrome following complex partial status epilepticus. (12791340)
2003
45
Malnutrition increases hippocampal neurogenesis in the immature rat after status epilepticus]. (14761318)
2003
46
Serum neuron-specific enolase in human status epilepticus. (7783877)
1995
47
Jarisch-Herxheimer reaction in a patient with neurosyphilis: non-convulsive status epilepticus? (7738586)
1995
48
Neuronal injury following electrically induced status epilepticus with and without adenosine receptor antagonism. (7649219)
1995
49
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. (8162392)
1993
50
Generalized tonic-clonic status epilepticus in a child with cat-scratch disease and encephalopathy. (1582050)
1992

Variations for Status Epilepticus

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Expression for genes affiliated with Status Epilepticus

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Search GEO for disease gene expression data for Status Epilepticus.

Pathways for genes affiliated with Status Epilepticus

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Compounds for genes affiliated with Status Epilepticus

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Compounds related to Status Epilepticus according to GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1dnqx43 1211.0BDNF, GRIA2
2axokine4310.0BDNF, CNR1
3aniracetam43 28 1211.9BDNF, GRIA2
4nbqx43 59 2811.9GRIA2, BDNF
5cyclothiazide43 28 1211.8BDNF, GRIA2
6ibotenic acid439.8GAD1, NPY
7cnqx43 5910.8GRIA2, BDNF
8sibutramine43 1210.7CNR1, NPY
9valproate439.6POLG, BDNF, GAD1
10levodopa43 1210.5GAD1, CNR1, BDNF
11baclofen43 1210.5GAD1, CNR1, NPY
12topiramate43 49 24 1212.5NPY, CNR1
13clozapine43 28 49 1212.5GAD1, BDNF, CNR1
14muscimol43 59 2811.3BDNF, NPY, GAD1
15capsaicin43 2810.3CNR1, BDNF, NPY
16mhpg439.3BDNF, NPY
17streptozotocin439.3GAD1, NPY, BDNF
18quisqualate43 1210.3GRIA2, BDNF
196-hydroxydopamine439.3GAP43, NPY, BDNF
20corticosterone43 59 2411.3NPY, BDNF, CNR1
21bromodeoxyuridine439.2BDNF, DCX, GAD1
22haloperidol43 49 28 2 1213.2GAD1, NPY, BDNF
23valproic acid43 49 24 1212.2BDNF, POLG, GAD1, GAP43
24alpha-amanitin439.2BDNF, JUN
25catecholamine439.1BDNF, NPY, GAP43
26arachidonic acid43 28 24 1212.1BDNF, GAP43, GRIA2, CNR1
27glutamine439.1POLG, NPY, GRIA2, GAD1
28aspartate439.0BDNF, CNR1, GAD1, GAP43
29carbachol43 28 1210.9GAP43, CNR1, BDNF, NPY
30choline43 24 1210.9BDNF, NPY, GAP43, GAD1
31norepinephrine43 24 1210.9BDNF, NPY, CNR1, GAP43
32vinblastine43 49 1210.9NPY, BDNF, JUN
33thapsigargin43 599.9NPY, BDNF, CNR1
34alanine438.7GAD1, GAP43, POLG, NPY, CNR1
35cocaine43 129.6NPY, GAP43, GRIA2, BDNF, CNR1
36adenylate438.6CNR1, POLG, GAP43, NPY, BDNF
37tetrodotoxin43 59 2810.5NPY, BDNF, CNR1, GAP43, GAD1
38gaba438.5GAP43, GAD1, NPY, BDNF, CNR1
39acetylcholine43 49 28 24 1212.5NPY, GAP43, GAD1, CNR1, BDNF
40dopamine43 28 24 1211.5BDNF, NPY, GAP43, GAD1, CNR1
41atp43 289.5NPY, POLG, GAD1, BDNF, GAP43
42forskolin43 49 1210.4NPY, BDNF, JUN, GAP43
43h2o2438.4JUN, BDNF, GAD1, GAP43
44nmda43 289.2BDNF, NPY, GAP43, GAD1, CNR1, GRIA2
45glutamate438.2CNR1, GAD1, GAP43, GRIA2, NPY, BDNF
46cyclic amp43 249.1NPY, BDNF, JUN, GAP43, CNR1
47serine437.8GAP43, DCX, JUN, GRIA2, BDNF, CNR1
48tyrosine437.7GAP43, NPY, BDNF, GAD1, GRIA2, JUN
49calcium43 49 24 1210.6BDNF, GAP43, GRIA2, GAD1, NPY, CNR1
50kainate43 287.9GAP43, NPY, GAD1, GRIA2, CNR1, JUN

GO Terms for genes affiliated with Status Epilepticus

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Cellular components related to Status Epilepticus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00080219.6BDNF, GRIA2

Biological processes related to Status Epilepticus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00076319.2BDNF, NPY
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.2CNR1, NPY
3synaptic transmissionGO:00072689.1NPY, GAD1, GRIA2
4agingGO:00075689.0CNR1, JUN, POLG

Products for genes affiliated with Status Epilepticus

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Sources for Status Epilepticus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet