SE
MCID: STT001
MIFTS: 65

Status Epilepticus (SE) malady

Rare diseases, Neuronal diseases categories
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Summaries for Status Epilepticus

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65Wikipedia, 33MalaCards
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Wikipedia:65 Status epilepticus (SE) is a life-threatening condition in which the brain is in a state of persistent... more...

MalaCards: Status Epilepticus, also known as generalized convulsive status epilepticus, is related to encephalitis and temporal lobe epilepsy. An important gene associated with Status Epilepticus is POLG (polymerase (DNA directed), gamma), and among its related pathways are Glutamic acid signaling and Circadian entrainment. The drugs amobarbital and diazepam and the compounds dnqx and axokine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related mouse phenotypes are taste/olfaction and reproductive system.

Aliases & Classifications for Status Epilepticus

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8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

status epilepticus 8 43 45 62
generalized convulsive status epilepticus 43
status epilepticus, unspecified 8
grand mal status epilepticus 62
status epilepticus nos 8
grand mal status 8
gcse 43
se 43


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Disease Ontology8 DOID:1824
NCIt40 C85079
MeSH35 D013226
ICD1025 G41, G41.0, G41.9

Related Diseases for Status Epilepticus

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17GeneCards, 18GeneDecks
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Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 669)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis31.0CNR1
2temporal lobe epilepsy30.8BDNF, NPY, GAD1
3herpes simplex30.1GAP43, BDNF, GAD1, POLG
4bipolar disorder30.0NPY, BDNF
5memory impairment30.0BDNF, GAP43, CNR1
6galactosemia30.0CNR1, POLG, NPY
7hypoglycemia29.9GAD1, BDNF, POLG, NPY
8parkinson's disease29.9BDNF, GAP43, GAD1, CNR1, POLG
9hyperglycemia29.8NPY, GAD1, JUN, BDNF
10schizophrenia29.8CNR1, GRIA2, BDNF, NPY, GAP43, GAD1
11multiple sclerosis29.8NPY, BDNF, GAD1, CNR1, JUN
12neuronitis10.8
13neurosyphilis10.5
14cerebritis10.5
15new-onset refractory status epilepticus10.4
16cat-scratch disease10.4
17limbic encephalitis10.4
18juvenile myoclonic epilepsy10.3
19focal epilepsy10.3
20hepatitis10.3
21febrile infection-related epilepsy syndrome10.3
22brain injury10.3
23lennox-gastaut syndrome10.3
24cadasil10.3
25acute intermittent porphyria10.3
26idiopathic generalized epilepsy10.3
27porphyria10.3
28polymicrogyria10.3
29pyridoxine-dependent epilepsy10.3
30ring chromosome 2010.3
31blindness10.3
32alpers syndrome10.2
33dravet syndrome10.2
34landau-kleffner syndrome10.2
35cortical blindness10.2
36melas syndrome10.2
37hepatic encephalopathy10.2
38meningitis10.2
39hemimegalencephaly10.2
40thanatophoric dysplasia type 110.2
41acute encephalopathy with inflammation-mediated status epilepticus10.2
42angelman syndrome10.1
43subacute sclerosing panencephalitis10.1
44thrombotic thrombocytopenic purpura10.1
45creutzfeldt-jakob disease10.1
46hypercalcemia10.1
47pulmonary edema10.1
48wolf-hirschhorn syndrome10.1
49l-2-hydroxyglutaric aciduria10.1
50metabolic acidosis10.1

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to status epilepticus

Symptoms for Status Epilepticus

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Drugs & Therapeutics for Status Epilepticus

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Status Epilepticus

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Anatomical Context for Status Epilepticus

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33MalaCards
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MalaCards organs/tissues related to Status Epilepticus:

33
Brain, Temporal lobe, Cortex, Amygdala, Endothelial, Bone, Bone marrow, Cerebellum, Pituitary, Skin, Monocytes, Breast, Heart, Thalamus

Animal Models for Status Epilepticus or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Status Epilepticus:

37 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2BDNF, GAD1, CNR1
2MP:00053898.4BDNF, GRIA2, CNR1, POLG, DCX
3MP:00053818.3POLG, CNR1, GAD1, NPY, BDNF
4MP:00053907.8POLG, JUN, CNR1, GAD1, NPY
5MP:00107717.8POLG, JUN, CNR1, GRIA2, BDNF
6MP:00028737.5JUN, CNR1, GRIA2, GAD1, NPY, BDNF
7MP:00053847.4POLG, JUN, CNR1, GRIA2, GAD1, GAP43
8MP:00030127.4DCX, POLG, JUN, CNR1, GRIA2, GAD1
9MP:00053767.2POLG, JUN, CNR1, GRIA2, GAD1, NPY
10MP:00053867.1DCX, JUN, CNR1, GRIA2, GAD1, NPY
11MP:00107686.9DCX, POLG, JUN, CNR1, GRIA2, GAD1
12MP:00036316.3BDNF, DCX, POLG, JUN, CNR1, GRIA2
13MP:00053786.3DCX, POLG, JUN, CNR1, GRIA2, GAD1

Publications for Status Epilepticus

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52PubMed
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Articles related to Status Epilepticus:

(show top 50)    (show all 675)
idTitleAuthorsYear
1
A girl with Cardio-facio-cutaneous syndrome complicated with status epilepticus and acute encephalopathy. (23340054)
2014
2
Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats. (24429728)
2014
3
Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy? (23266599)
2013
4
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
5
Ginseng extract attenuates early MRI changes after status epilepticus and decreases subsequent reduction of hippocampal volume in the rat brain. (24359691)
2013
6
Propofol versus thiopental sodium for the treatment of refractory status epilepticus (Review). (23877948)
2013
7
Good functional outcome after prolonged postanoxic comatose myoclonic status epilepticus in a patient who had undergone bone marrow transplantation. (24368951)
2013
8
Adjunctive enteral phenobarbital for adult status epilepticus: a brief report. (24379674)
2013
9
Primary antiphospholipid syndrome manifesting as partial status epilepticus. (23545615)
2013
10
The multifaceted care of status epilepticus. (24001076)
2013
11
Usefulness of intravenous lacosamide in status epilepticus. (24122063)
2013
12
Turning up the heat on the impact of febrile status epilepticus. (23447728)
2013
13
Subclinical epileptiform activity in children with electrical status epilepticus during sleep: effects on cognition and behavior before and after treatment with levetiracetam. (23376335)
2013
14
Analysis of the delay components in the treatment of status epilepticus. (23817962)
2013
15
Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. (23758557)
2013
16
Intravenous initiation and maintenance of ketogenic diet: proof of concept in super-refractory status epilepticus. (23597842)
2013
17
What is the easier and more reliable dose calculation for iv phenytoin in children at risk of developing convulsive status epilepticus, 18 mg/kg or 20 mg/kg? (23601207)
2013
18
Effect of the calcineurin inhibitor FK506 on K+-Cl- cotransporter 2 expression in the mouse hippocampus after kainic acid-induced status epilepticus. (22160488)
2012
19
Early appearance of diffusion-weighted hyperintensities in aphasic status epilepticus. A case report. (24028874)
2012
20
Frequency of non-convulsive seizures and non-convulsive status epilepticus in subarachnoid hemorrhage patients in need of controlled ventilation and sedation. (22932991)
2012
21
Sporadic Creutzfeldt-Jakob disease in a patient with episodes of nonconvulsive status epilepticus: case report. (22920008)
2012
22
Persistent decrease in multiple components of the perineuronal net following status epilepticus. (22934955)
2012
23
Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. (22591751)
2012
24
Guidelines for status epilepticus: are we there yet? (22696014)
2012
25
Deep hypothermia terminates status epilepticus--an experimental study. (22365745)
2012
26
The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. (22577217)
2012
27
Pupillary hippus in nonconvulsive status epilepticus. (22940244)
2012
28
Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). (22509732)
2012
29
Cognitive outcome of status epilepticus in children. (22957250)
2012
30
Non-convulsive status epilepticus in comatose patients (case reports). (22859443)
2012
31
A case of central cord syndrome related status epilepticus - a case report -. (22506176)
2011
32
Mild hypothermia for refractory focal status epilepticus in an infant with hemimegalencephaly. (20060761)
2010
33
Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. (18294203)
2008
34
Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury induction. (18511210)
2008
35
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. (17630998)
2007
36
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
37
Advances in the pathophysiology of status epilepticus. (17784531)
2007
38
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
39
Age-related electrical status epilepticus during sleep and epileptic negative myoclonus in DRPLA. (16534126)
2006
40
Altered expression of GABA(A) and GABA(B) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. (15951123)
2005
41
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. (16190927)
2005
42
Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: induced abortion as the sole therapeutic option? (15469454)
2004
43
Landau-Kleffner syndrome, electrical status epilepticus in slow wave sleep, and language regression in children. (15362173)
2004
44
Transient Kluver-Bucy syndrome following complex partial status epilepticus. (12791340)
2003
45
Malnutrition increases hippocampal neurogenesis in the immature rat after status epilepticus]. (14761318)
2003
46
Serum neuron-specific enolase in human status epilepticus. (7783877)
1995
47
Jarisch-Herxheimer reaction in a patient with neurosyphilis: non-convulsive status epilepticus? (7738586)
1995
48
Neuronal injury following electrically induced status epilepticus with and without adenosine receptor antagonism. (7649219)
1995
49
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. (8162392)
1993
50
Generalized tonic-clonic status epilepticus in a child with cat-scratch disease and encephalopathy. (1582050)
1992

Variations for Status Epilepticus

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Expression for genes affiliated with Status Epilepticus

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Status Epilepticus

Search GEO for disease gene expression data for Status Epilepticus.

Pathways for genes affiliated with Status Epilepticus

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50PathCards, 12EMD Millipore, 54R&D Systems, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 5Cell Signaling Technology
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Compounds for genes affiliated with Status Epilepticus

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45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Status Epilepticus according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1dnqx45 1111.0BDNF, GRIA2
2axokine4510.0BDNF, CNR1
3aniracetam45 29 1111.9BDNF, GRIA2
4nbqx45 61 2911.9GRIA2, BDNF
5cyclothiazide45 29 1111.8BDNF, GRIA2
6ibotenic acid459.8GAD1, NPY
7cnqx45 6110.8GRIA2, BDNF
8sibutramine45 1110.7CNR1, NPY
9valproate459.6POLG, BDNF, GAD1
10levodopa45 1110.5GAD1, CNR1, BDNF
11baclofen45 1110.5GAD1, CNR1, NPY
12topiramate45 51 24 1112.5NPY, CNR1
13clozapine45 29 51 1112.5GAD1, BDNF, CNR1
14muscimol45 61 2911.3BDNF, NPY, GAD1
15capsaicin45 2910.3CNR1, BDNF, NPY
16mhpg459.3BDNF, NPY
17streptozotocin459.3GAD1, NPY, BDNF
18quisqualate45 1110.3GRIA2, BDNF
196-hydroxydopamine459.3GAP43, NPY, BDNF
20corticosterone45 61 2411.3NPY, BDNF, CNR1
21bromodeoxyuridine459.2BDNF, DCX, GAD1
22haloperidol45 51 29 3 1113.2GAD1, NPY, BDNF
23valproic acid45 51 24 1112.2BDNF, POLG, GAD1, GAP43
24alpha-amanitin459.2BDNF, JUN
25catecholamine459.1BDNF, NPY, GAP43
26arachidonic acid45 29 24 1112.1BDNF, GAP43, GRIA2, CNR1
27glutamine459.1POLG, NPY, GRIA2, GAD1
28aspartate459.0BDNF, CNR1, GAD1, GAP43
29carbachol45 29 1110.9GAP43, CNR1, BDNF, NPY
30choline45 24 1110.9BDNF, NPY, GAP43, GAD1
31norepinephrine45 24 1110.9BDNF, NPY, CNR1, GAP43
32vinblastine45 51 1110.9NPY, BDNF, JUN
33thapsigargin45 619.9NPY, BDNF, CNR1
34alanine458.7GAD1, GAP43, POLG, NPY, CNR1
35cocaine45 119.6NPY, GAP43, GRIA2, BDNF, CNR1
36adenylate458.6CNR1, POLG, GAP43, NPY, BDNF
37tetrodotoxin45 61 2910.5NPY, BDNF, CNR1, GAP43, GAD1
38gaba458.5GAP43, GAD1, NPY, BDNF, CNR1
39acetylcholine45 51 29 24 1112.5NPY, GAP43, GAD1, CNR1, BDNF
40dopamine45 29 24 1111.5BDNF, NPY, GAP43, GAD1, CNR1
41atp45 299.5NPY, POLG, GAD1, BDNF, GAP43
42forskolin45 51 1110.4NPY, BDNF, JUN, GAP43
43h2o2458.4JUN, BDNF, GAD1, GAP43
44nmda45 299.2BDNF, NPY, GAP43, GAD1, CNR1, GRIA2
45glutamate458.2CNR1, GAD1, GAP43, GRIA2, NPY, BDNF
46cyclic amp45 249.1NPY, BDNF, JUN, GAP43, CNR1
47serine457.8GAP43, DCX, JUN, GRIA2, BDNF, CNR1
48tyrosine457.7GAP43, NPY, BDNF, GAD1, GRIA2, JUN
49calcium45 51 24 1110.6BDNF, GAP43, GRIA2, GAD1, NPY, CNR1
50kainate45 297.9GAP43, NPY, GAD1, GRIA2, CNR1, JUN

GO Terms for genes affiliated with Status Epilepticus

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16Gene Ontology
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Cellular components related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.6BDNF, GRIA2

Biological processes related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:0076319.2BDNF, NPY
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.2CNR1, NPY
3synaptic transmissionGO:0072689.1NPY, GAD1, GRIA2
4agingGO:0075689.0CNR1, JUN, POLG

Products for genes affiliated with Status Epilepticus

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Sources for Status Epilepticus

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet