SE
MCID: STT001
MIFTS: 66

Status Epilepticus (SE) malady

Neuronal diseases category

Summaries for Status Epilepticus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Status epilepticus (SE) is a life-threatening condition in which the brain is in a state of persistent... more...

MalaCards: Status Epilepticus, also known as generalized convulsive status epilepticus, is related to encephalitis and temporal lobe epilepsy. An important gene associated with Status Epilepticus is POLG (polymerase (DNA directed), gamma), and among its related pathways are N-cadherin signaling events and Glutamic acid signaling. The drugs amobarbital and diazepam and the compounds bicuculline and baclofen have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related mouse phenotypes are no phenotypic analysis and normal.

Aliases & Classifications for Status Epilepticus

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

status epilepticus 8 42 44 60
generalized convulsive status epilepticus 42
status epilepticus, unspecified 8
grand mal status epilepticus 60
status epilepticus nos 8
grand mal status 8
gcse 42
se 42


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Disease Ontology8 DOID:1824
NCIt39 C85079
MeSH34 D013226
ICD1025 G41, G41.0, G41.9

Related Diseases for Status Epilepticus

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 721)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis30.8LGI1, CNR1, CALB1
2temporal lobe epilepsy30.7BDNF, CALB1, NPY, GAD1, LGI1
3focal epilepsy30.5DCX, LGI1
4diabetes mellitus30.3JUN, NPY, GAD1, CNR1
5epilepsy syndrome30.2HCN2, POLG, GRM2, GRIA2, DCX, GAD1
6hypertension30.1NPY
7herpes simplex30.1BDNF, CALB1, GAP43, GAD1, POLG
8central hypoventilation syndrome, congenital, with or without hirschsprung disease30.1BDNF, ASCL1
9leukemia30.0JUN, GAP43, CNR1
10migraine29.9CNR1
11hypoglycemia29.9POLG, GAD1, NPY, BDNF
12ganglioglioma29.9ENO2, DCX
13drug dependence29.9CNR1
14multiple sclerosis29.9JUN, BDNF, NPY, GAD1, CNR1
15parkinson's disease29.9BDNF, CALB1, GAP43, GAD1, POLG, CNR1
16hyperglycemia29.9JUN, BDNF, NPY, GAD1
17schizophrenia29.9BDNF, CALB1, NPY, GAP43, GAD1, GRIA2
18bipolar disorder29.9NPY, BDNF
19retinitis29.7DCX
20ischemia29.7BDNF, GAP43, GAD1, DFFB, DCX, GRIA2
21adenocarcinoma29.7BDNF, DFFB, CNR1, ENO2, ASCL1
22neuronitis10.8
23cerebritis10.5
24cat-scratch disease10.3
25juvenile myoclonic epilepsy10.3
26hepatitis10.3
27pyridoxine-dependent epilepsy10.3
28arthritis10.3
29rheumatoid arthritis10.3
30lennox-gastaut syndrome10.2
31cadasil10.2
32landau-kleffner syndrome10.2
33acute intermittent porphyria10.2
34acute porphyria10.2
35idiopathic generalized epilepsy10.2
36porphyria10.2
37polymicrogyria10.2
38febrile infection-related epilepsy syndrome10.2
39alpers syndrome10.2
40melas syndrome10.2
41dravet syndrome10.2
42cortical blindness10.2
43hepatic encephalopathy10.2
44meningitis10.2
45thanatophoric dysplasia type 110.2
46subacute sclerosing panencephalitis10.1
47angelman syndrome10.1
48pulmonary edema10.1
49mucopolysaccharidosis ii10.1
50wolf-hirschhorn syndrome10.1

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to status epilepticus

Clinical Features for Status Epilepticus

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Drugs & Therapeutics for Status Epilepticus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Status Epilepticus

Drug clinical trials:

Search ClinicalTrials for Status Epilepticus

Search NIH Clinical Center for Status Epilepticus

Search CenterWatch for Status Epilepticus

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Status Epilepticus

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Anatomical Context for Status Epilepticus

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32MalaCards
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MalaCards organs/tissues related to Status Epilepticus:

32
Brain, Temporal lobe, Cortex, Amygdala, Bone marrow, Bone, Endothelial, Thalamus, Monocytes, Skin, Breast, Heart, Cerebellum, Pituitary

Animal Models for Status Epilepticus or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Status Epilepticus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.3JUN, BDNF, GABRA4, GAD1, DCX, GRIA2
2MP:000287310.2ASCL1, GRIA2, GAD1, GABRA4, NPY, BDNF
3MP:001077110.2JUN, BDNF, GABRA4, GRIA2, POLG, HCN2
4MP:000537810.2GAD1, GAP43, NPY, BDNF, JUN, DFFB
5MP:001076810.1DCX, GAD1, GAP43, BDNF, JUN, GRIA2
6MP:000538410.1JUN, BDNF, GAP43, GAD1, DFFB, GRIA2
7MP:000538610.1DCX, GAD1, GABRA4, NPY, CALB1, BDNF
8MP:000363110.0NHLRC1, JUN, BDNF, CALB1, NPY, GABRA4
9MP:000537610.0GAD1, NPY, BDNF, JUN, GRIA2, GRM2
10MP:000537710.0BDNF, CALB1, GRIA2, POLG, HCN2

Publications for Status Epilepticus

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50PubMed
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Articles related to Status Epilepticus:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. (24051278)
2014
2
Analysis of the delay components in the treatment of status epilepticus. (23817962)
2013
3
Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis. (23623775)
2013
4
Episodes of status epilepticus in young adults: etiologic factors, subtypes, and outcomes. (23537621)
2013
5
What is specialized care in status epilepticus and in which ICU? (23715668)
2013
6
Spectrum of nonconvulsive status epilepticus in patients with cancer. (23912570)
2013
7
Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience. (24316167)
2013
8
Stiripentol is anticonvulsant by potentiating GABAergic transmission in a model of benzodiazepine-refractory status epilepticus. (23168114)
2013
9
Managing the generalised tonic-clonic seizure and preventing progress to status epilepticus: a stepwise approach. (23614871)
2013
10
Intravenous Lacosamide in Refractory Seizure Clusters and Status Epilepticus: Comparison of 200 and 400A mg Loading Doses. (23896816)
2013
11
Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model. (23212179)
2013
12
Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus. (24015271)
2013
13
The proceedings of the fourth London-Innsbruck-Colloquium on Status Epilepticus, April 4a896, 2013, Salzburg, Austria. (24244960)
2013
14
Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats. (23194667)
2013
15
Genome-Wide microRNA Profiling of Rat Hippocampus after Status Epilepticus Induced by Amygdala Stimulation Identifies Modulators of Neuronal Apoptosis. (24205215)
2013
16
Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079. (23808395)
2013
17
Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. (23724051)
2013
18
Pathology of bilateral pulvinar degeneration following long duration status epilepticus. (23962521)
2013
19
Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. (23536771)
2013
20
Autoimmune encephalitis: A potentially reversible cause of status epilepticus, epilepsy, and cognitive decline. (24339583)
2013
21
Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus. (23839305)
2013
22
The importance of treatment protocols for the management of status epilepticus. (24367120)
2013
23
Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. (23886585)
2013
24
Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. (22591751)
2012
25
Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. (22326977)
2012
26
Status epilepticus associated with dalfampridine in a patient with multiple sclerosis. (23224484)
2012
27
Unprovoked status epilepticus: the prognosis for otherwise normal children with focal epilepsy. (22908107)
2012
28
Seizures and status epilepticus in post cardiac arrest syndrome: therapeutic opportunities to improve outcome or basis to withhold life sustaining therapies? (22513351)
2012
29
Fear as nonconvulsive status epilepticus of frontal origin: EEG-SPECT correlation. (22554979)
2012
30
Characterization of status epilepticus induced by two organophosphates in rats. (22578704)
2012
31
Too much, too little, too late: treating status epilepticus without coma induction? (22903104)
2012
32
IV Valproate in generalized convulsive status epilepticus: a systematic review. (22182304)
2012
33
Clinical status epilepticus due to anaplastic cortical ependymoma. (22209145)
2012
34
Charcoal hemoperfusion for bupropion overdose with ventricular tachycardia and status epilepticus. (22333014)
2012
35
Longitudinal A^H MRS assessment of the thalamus in a Coriaria lactone-induced rhesus monkey status epilepticus model. (22389048)
2012
36
Tumor necrosis factor-I+-mediated threonine 435 phosphorylation of p65 nuclear factor-I_B subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus. (22240205)
2012
37
Treatment of refractory tonic status epilepticus with intravenous lacosamide. (22462573)
2012
38
Non-convulsive status epilepticus characterised exclusively by a language disorder induced by non-ketotic hyperglycaemia. (21550922)
2011
39
What is the value of hypothermia in acute neurologic diseases and status epilepticus? (21967367)
2011
40
Non-convulsive status epilepticus causing focal neurological deficits in CADASIL. (21686667)
2009
41
Neuroserpin mutation causes electrical status epilepticus of slow-wave sleep. (18591508)
2008
42
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. (17630998)
2007
43
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus. (17913901)
2007
44
Age-related electrical status epilepticus during sleep and epileptic negative myoclonus in DRPLA. (16534126)
2006
45
Neurosyphilis presenting with status epilepticus. (17122728)
2006
46
Altered expression of GABA(A) and GABA(B) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. (15951123)
2005
47
Cat-scratch disease causing status epilepticus in children. (9932833)
1999
48
Serum NSE in status epilepticus. (8649598)
1996
49
Jarisch-Herxheimer reaction in a patient with neurosyphilis: non-convulsive status epilepticus? (7738586)
1995
50
Neuropathologic asymmetries in the brain of a patient with a unilateral status epilepticus. (1715386)
1991

Genetic Variations for Status Epilepticus

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Expression for genes affiliated with Status Epilepticus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Status Epilepticus

Search GEO for disease gene expression data for Status Epilepticus.

Pathways for genes affiliated with Status Epilepticus

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Compounds for genes affiliated with Status Epilepticus

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Status Epilepticus according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1bicuculline44 2811.8GAD1, GABRA4
2baclofen44 1111.8CNR1, NPY, GAD1
3dnqx44 1111.8GRIA2, BDNF
4axokine4410.8CNR1, BDNF
5quisqualate44 1111.8BDNF, GRIA2, GRM2
6muscimol44 59 2812.8GAD1, GABRA4, NPY, BDNF
7nmda44 2811.8CNR1, GRM2, GAD1, BDNF, GAP43
8forskolin44 49 1112.7NPY, ENO2, GRM2, GAP43
9quinolinic acid44 2411.7BDNF, GAD1, CALB1
10catecholamine4410.7GAP43, NPY, BDNF, ENO2
11cocaine44 1111.7NPY, BDNF, SLC18A3, CNR1, GRIA2, GAP43
12taurine44 59 2412.7CALB1, ENO2, GAD1
13bromodeoxyuridine4410.7ENO2, GAD1, DCX, BDNF, CALB1
14carbachol44 28 1112.7BDNF, NPY, CNR1, GAP43
15valproate4410.7POLG, GAD1, BDNF
16glutamate4410.7GAD1, NPY, CALB1, GRIA2, GRM2, SLC18A3
17spec-t4410.7CNR1, SLC18A3, ENO2
18tetrodotoxin44 59 2812.7CNR1, ENO2, GAD1, GAP43, NPY, CALB1
19norepinephrine44 11 2412.7BDNF, CALB1, NPY, GAP43, CNR1, ENO2
20adenylate4410.7NPY, ENO2, GAP43, POLG, BDNF, CNR1
215-hydroxytryptamine4410.7NPY, CNR1, ENO2, CALB1
22streptozotocin4410.7GAD1, NPY, BDNF
23aspartate4410.7GRM2, ENO2, GAD1, GAP43, BDNF, CNR1
24methamphetamine44 49 1112.6CALB1, BDNF, NPY
25choline44 11 2412.6CALB1, BDNF, NPY, GAP43, GAD1, SLC18A3
26cyclic amp44 2411.6JUN, GRM2, BDNF, NPY, CNR1, HCN2
27potassium44 11 2412.6ENO2, GAD1, CALB1, HCN2, BDNF, LGI1
286-hydroxydopamine4410.6BDNF, GAP43, NPY
29arachidonic acid44 28 11 2413.6CNR1, GAP43, BDNF, CPT1B, GRIA2
30acetylcholine44 49 28 11 2414.6NPY, BDNF, CALB1, GAP43, GAD1, CNR1
31glutamine4410.6NPY, GRIA2, POLG, ENO2, GAD1
32aniracetam28 44 1112.6BDNF, GRIA2
33kainate44 2811.6BDNF, DCX, GRIA2, GRM2, CNR1, GAP43
34mptp4410.6CALB1, BDNF, GAD1
35gaba4410.6GRM2, ENO2, BDNF, CALB1, CNR1, NPY
36acth4410.6GAP43, BDNF, NPY, ENO2
37ibotenic acid4410.6NPY, GAD1
38retinoic acid44 2411.6ASCL1, ENO2, SLC18A3, GAP43, NPY, CALB1
39atp44 2811.6SLC18A3, POLG, DFFB, GAD1, GAP43, CALB1
40glucose4410.5CALB1, NPY, GAD1, CNR1, ENO2, CPT1B
41dopamine44 28 11 2413.5BDNF, CALB1, GAP43, GAD1, GRM2, NPY
42calcium44 49 11 2413.5ENO2, GRM2, GRIA2, DCX, GAD1, GAP43
43tyrosine4410.5GRM2, SLC18A3, GRIA2, GAD1, CALB1, JUN
44nitric oxide44 11 2412.4CALB1, GAP43, GAD1, SLC18A3, ENO2, NPY
45capsaicin44 2811.4NPY, BDNF, CNR1
46sodium44 2411.4ENO2, LGI1, SLC18A3, BDNF, HCN2
47vinblastine44 49 1112.4JUN, NPY, BDNF
48alanine4410.4GAD1, NPY, GAP43, ENO2, CNR1, POLG
49nbqx44 59 2812.3BDNF, GRIA2
50n-acetylaspartate4410.1CALB1, BDNF

GO Terms for genes affiliated with Status Epilepticus

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Sources:
16Gene Ontology
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Cellular components related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.3LGI1, GRM2, GRIA2, GAP43, GABRA4

Biological processes related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:01404710.4GRM2, BDNF
2agingGO:00756810.3JUN, POLG, CNR1
3synaptic transmissionGO:00726810.2SLC18A3, HCN2, GRM2, GRIA2, GAD1, GABRA4
4central nervous system neuron developmentGO:02195410.1ASCL1, NPY

Molecular functions related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel regulator activityGO:00524610.4GRM2, NPY
2glutamate receptor activityGO:00806610.1GRM2, GRIA2

Products for genes affiliated with Status Epilepticus

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  • Antibodies
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Sources for Status Epilepticus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet