SE
MCID: STT001
MIFTS: 66

Status Epilepticus (SE) malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Status Epilepticus

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Wikipedia:65 Status epilepticus (SE) is an epileptic seizure of greater than five minutes or more than one seizure... more...

MalaCards based summary: Status Epilepticus, also known as generalized convulsive status epilepticus, is related to encephalitis and temporal lobe epilepsy. An important gene associated with Status Epilepticus is POLG (polymerase (DNA directed), gamma), and among its related pathways are Glutamic acid signaling and Circadian entrainment. The drugs amobarbital and lorazepam and the compounds dnqx and axokine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related mouse phenotypes are taste/olfaction and reproductive system.

Aliases & Classifications for Status Epilepticus

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Status Epilepticus, Aliases & Descriptions:

Name: Status Epilepticus 8 42 44 62
Generalized Convulsive Status Epilepticus 42 62
Status Epilepticus, Unspecified 8
Grand Mal Status Epilepticus 62
 
Status Epilepticus Nos 8
Grand Mal Status 8
Gcse 42
Se 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:1824
NCIt39 C85079
MeSH34 D013226

Related Diseases for Status Epilepticus

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Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 666)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis31.4CNR1
2temporal lobe epilepsy30.8BDNF, NPY, GAD1
3bipolar disorder30.1BDNF, NPY
4cholera30.1CNR1, GAD1, GAP43
5memory impairment30.1BDNF, GAP43, CNR1
6herpes simplex30.1POLG, GAD1, GAP43, BDNF
7hypoglycemia29.7POLG, GAD1, NPY, BDNF
8parkinson's disease29.6POLG, CNR1, GAD1, GAP43, BDNF
9hyperglycemia29.4JUN, GAD1, NPY, BDNF
10schizophrenia29.2CNR1, GRIA2, GAD1, GAP43, NPY, BDNF
11multiple sclerosis29.2JUN, CNR1, GAD1, NPY, BDNF
12epilepsy syndrome28.6DCX, POLG, CNR1, GRIA2, GAD1, GAP43
13neuronitis10.8
14neurosyphilis10.5
15cerebritis10.5
16norse10.5
17cat-scratch disease10.4
18febrile infection-related epilepsy syndrome10.4
19limbic encephalitis10.4
20brain injury10.3
21hepatitis10.3
22juvenile myoclonic epilepsy10.3
23focal epilepsy10.3
24pyridoxine-dependent epilepsy10.3
25ring chromosome 2010.3
26cadasil10.3
27lennox-gastaut syndrome10.3
28dravet syndrome10.3
29acute intermittent porphyria10.3
30idiopathic generalized epilepsy10.3
31porphyria10.3
32polymicrogyria10.3
33blindness10.3
34landau-kleffner syndrome10.2
35alpers syndrome10.2
36cortical blindness10.2
37melas syndrome10.2
38hepatic encephalopathy10.2
39meningitis10.2
40hemimegalencephaly10.2
41thanatophoric dysplasia type 110.2
42myoclonus10.2
43endogenous depression10.2BDNF, GAD1
44central nervous system disease10.2BDNF, CNR1
45motor neuron disease10.2GRIA2, BDNF
46autonomic neuropathy10.1NPY, GAD1
47west syndrome10.1
48crigler-najjar syndrome10.1
49hypertension10.1
50fragile x syndrome10.1

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to status epilepticus

Symptoms for Status Epilepticus

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Drugs & Therapeutics for Status Epilepticus

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Genetic Tests for Status Epilepticus

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Anatomical Context for Status Epilepticus

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MalaCards organs/tissues related to Status Epilepticus:

32
Brain, Temporal lobe, Cortex, Amygdala, Bone marrow, Bone, Endothelial, Cerebellum, Heart, Thyroid, Breast, Skin, Monocytes, Thalamus, Pituitary, Neutrophil

Animal Models for Status Epilepticus or affiliated genes

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MGI Mouse Phenotypes related to Status Epilepticus:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2BDNF, GAD1, CNR1
2MP:00053898.4BDNF, GRIA2, CNR1, POLG, DCX
3MP:00053818.3POLG, CNR1, GAD1, NPY, BDNF
4MP:00053907.8POLG, JUN, CNR1, GAD1, NPY
5MP:00107717.8POLG, JUN, CNR1, GRIA2, BDNF
6MP:00028737.5JUN, CNR1, GRIA2, GAD1, NPY, BDNF
7MP:00053847.4POLG, JUN, CNR1, GRIA2, GAD1, GAP43
8MP:00030127.4DCX, POLG, JUN, CNR1, GRIA2, GAD1
9MP:00053767.2POLG, JUN, CNR1, GRIA2, GAD1, NPY
10MP:00053867.1DCX, JUN, CNR1, GRIA2, GAD1, NPY
11MP:00107686.9DCX, POLG, JUN, CNR1, GRIA2, GAD1
12MP:00036316.3BDNF, DCX, POLG, JUN, CNR1, GRIA2
13MP:00053786.3DCX, POLG, JUN, CNR1, GRIA2, GAD1

Publications for Status Epilepticus

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Articles related to Status Epilepticus:

(show top 50)    (show all 711)
idTitleAuthorsYear
1
Syndromes at risk of status epilepticus in children: genetic and pathophysiological issues. (25323303)
2014
2
Attitude of epilepsy patients and their attendants for participating in research on status epilepticus. (25376558)
2014
3
A girl with Cardio-facio-cutaneous syndrome complicated with status epilepticus and acute encephalopathy. (23340054)
2014
4
Outcome of status epilepticus. What do we learn from animal data? (25322806)
2014
5
Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats. (24429728)
2014
6
Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy? (23266599)
2013
7
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
8
Ginseng extract attenuates early MRI changes after status epilepticus and decreases subsequent reduction of hippocampal volume in the rat brain. (24359691)
2013
9
Propofol versus thiopental sodium for the treatment of refractory status epilepticus (Review). (23877948)
2013
10
Good functional outcome after prolonged postanoxic comatose myoclonic status epilepticus in a patient who had undergone bone marrow transplantation. (24368951)
2013
11
Adjunctive enteral phenobarbital for adult status epilepticus: a brief report. (24379674)
2013
12
Primary antiphospholipid syndrome manifesting as partial status epilepticus. (23545615)
2013
13
The multifaceted care of status epilepticus. (24001076)
2013
14
Usefulness of intravenous lacosamide in status epilepticus. (24122063)
2013
15
Turning up the heat on the impact of febrile status epilepticus. (23447728)
2013
16
Subclinical epileptiform activity in children with electrical status epilepticus during sleep: effects on cognition and behavior before and after treatment with levetiracetam. (23376335)
2013
17
Analysis of the delay components in the treatment of status epilepticus. (23817962)
2013
18
Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. (23758557)
2013
19
Intravenous initiation and maintenance of ketogenic diet: proof of concept in super-refractory status epilepticus. (23597842)
2013
20
Effect of the calcineurin inhibitor FK506 on K+-Cl- cotransporter 2 expression in the mouse hippocampus after kainic acid-induced status epilepticus. (22160488)
2012
21
Early appearance of diffusion-weighted hyperintensities in aphasic status epilepticus. A case report. (24028874)
2012
22
Frequency of non-convulsive seizures and non-convulsive status epilepticus in subarachnoid hemorrhage patients in need of controlled ventilation and sedation. (22932991)
2012
23
Sporadic Creutzfeldt-Jakob disease in a patient with episodes of nonconvulsive status epilepticus: case report. (22920008)
2012
24
Persistent decrease in multiple components of the perineuronal net following status epilepticus. (22934955)
2012
25
Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression. (22591751)
2012
26
Guidelines for status epilepticus: are we there yet? (22696014)
2012
27
Deep hypothermia terminates status epilepticus--an experimental study. (22365745)
2012
28
The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. (22577217)
2012
29
Pupillary hippus in nonconvulsive status epilepticus. (22940244)
2012
30
Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). (22509732)
2012
31
Cognitive outcome of status epilepticus in children. (22957250)
2012
32
Non-convulsive status epilepticus in comatose patients (case reports). (22859443)
2012
33
A case of central cord syndrome related status epilepticus - a case report -. (22506176)
2011
34
Mild hypothermia for refractory focal status epilepticus in an infant with hemimegalencephaly. (20060761)
2010
35
Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. (18294203)
2008
36
Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury induction. (18511210)
2008
37
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. (17630998)
2007
38
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
39
Advances in the pathophysiology of status epilepticus. (17784531)
2007
40
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
41
Age-related electrical status epilepticus during sleep and epileptic negative myoclonus in DRPLA. (16534126)
2006
42
Altered expression of GABA(A) and GABA(B) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. (15951123)
2005
43
Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: induced abortion as the sole therapeutic option? (15469454)
2004
44
Landau-Kleffner syndrome, electrical status epilepticus in slow wave sleep, and language regression in children. (15362173)
2004
45
Malnutrition increases hippocampal neurogenesis in the immature rat after status epilepticus]. (14761318)
2003
46
Serum neuron-specific enolase in human status epilepticus. (7783877)
1995
47
Jarisch-Herxheimer reaction in a patient with neurosyphilis: non-convulsive status epilepticus? (7738586)
1995
48
Neuronal injury following electrically induced status epilepticus with and without adenosine receptor antagonism. (7649219)
1995
49
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. (8162392)
1993
50
Generalized tonic-clonic status epilepticus in a child with cat-scratch disease and encephalopathy. (1582050)
1992

Variations for Status Epilepticus

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Expression for genes affiliated with Status Epilepticus

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Expression patterns in normal tissues for genes affiliated with Status Epilepticus

Search GEO for disease gene expression data for Status Epilepticus.

Pathways for genes affiliated with Status Epilepticus

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Compounds for genes affiliated with Status Epilepticus

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Compounds related to Status Epilepticus according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1dnqx44 1111.0BDNF, GRIA2
2axokine4410.0BDNF, CNR1
3aniracetam44 28 1111.9BDNF, GRIA2
4nbqx44 61 2811.9GRIA2, BDNF
5cyclothiazide44 28 1111.8BDNF, GRIA2
6ibotenic acid449.8GAD1, NPY
7cnqx44 6110.8GRIA2, BDNF
8sibutramine44 1110.7CNR1, NPY
9valproate449.6POLG, BDNF, GAD1
10levodopa44 1110.5GAD1, CNR1, BDNF
11baclofen44 1110.5GAD1, CNR1, NPY
12topiramate44 50 24 1112.5NPY, CNR1
13clozapine44 28 50 1112.5GAD1, BDNF, CNR1
14muscimol44 61 2811.3BDNF, NPY, GAD1
15capsaicin44 2810.3CNR1, BDNF, NPY
16mhpg449.3BDNF, NPY
17streptozotocin449.3GAD1, NPY, BDNF
18quisqualate44 1110.3GRIA2, BDNF
196-hydroxydopamine449.3GAP43, NPY, BDNF
20corticosterone44 61 2411.3NPY, BDNF, CNR1
21bromodeoxyuridine449.2BDNF, DCX, GAD1
22haloperidol44 50 28 2 1113.2GAD1, NPY, BDNF
23valproic acid44 50 24 1112.2BDNF, POLG, GAD1, GAP43
24alpha-amanitin449.2BDNF, JUN
25catecholamine449.1BDNF, NPY, GAP43
26arachidonic acid44 28 24 1112.1BDNF, GAP43, GRIA2, CNR1
27glutamine449.1POLG, NPY, GRIA2, GAD1
28aspartate449.0BDNF, CNR1, GAD1, GAP43
29carbachol44 28 1110.9GAP43, CNR1, BDNF, NPY
30choline44 24 1110.9BDNF, NPY, GAP43, GAD1
31norepinephrine44 24 1110.9BDNF, NPY, CNR1, GAP43
32vinblastine44 50 1110.9NPY, BDNF, JUN
33thapsigargin44 619.9NPY, BDNF, CNR1
34alanine448.7GAD1, GAP43, POLG, NPY, CNR1
35cocaine44 119.6NPY, GAP43, GRIA2, BDNF, CNR1
36adenylate448.6CNR1, POLG, GAP43, NPY, BDNF
37tetrodotoxin44 61 2810.5NPY, BDNF, CNR1, GAP43, GAD1
38gaba448.5GAP43, GAD1, NPY, BDNF, CNR1
39acetylcholine44 50 28 24 1112.5NPY, GAP43, GAD1, CNR1, BDNF
40dopamine44 28 24 1111.5BDNF, NPY, GAP43, GAD1, CNR1
41atp44 289.5NPY, POLG, GAD1, BDNF, GAP43
42forskolin44 50 1110.4NPY, BDNF, JUN, GAP43
43h2o2448.4JUN, BDNF, GAD1, GAP43
44nmda44 289.2BDNF, NPY, GAP43, GAD1, CNR1, GRIA2
45glutamate448.2CNR1, GAD1, GAP43, GRIA2, NPY, BDNF
46cyclic amp44 249.1NPY, BDNF, JUN, GAP43, CNR1
47serine447.8GAP43, DCX, JUN, GRIA2, BDNF, CNR1
48tyrosine447.7GAP43, NPY, BDNF, GAD1, GRIA2, JUN
49calcium44 50 24 1110.6BDNF, GAP43, GRIA2, GAD1, NPY, CNR1
50kainate44 287.9GAP43, NPY, GAD1, GRIA2, CNR1, JUN

GO Terms for genes affiliated with Status Epilepticus

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Cellular components related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.6BDNF, GRIA2

Biological processes related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:0076319.2BDNF, NPY
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.2CNR1, NPY
3synaptic transmissionGO:0072689.1NPY, GAD1, GRIA2
4agingGO:0075689.0CNR1, JUN, POLG

Products for genes affiliated with Status Epilepticus

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Sources for Status Epilepticus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet