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MCID: STT001

Status Epilepticus malady
14 drugs, 74 genes, 4 tissues, 533 related diseases, 20 phenotypes, 59 articles, clinical trials.

Summaries for Status Epilepticus

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44Wikipedia, 22MalaCards
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Wikipedia: Status epilepticus (SE) is a life-threatening condition in which the brain is in a state of persistent...44 more...

MalaCards: Status Epilepticus, also known as status epilepticus, unspecified (disorder), is related to pyridoxine-dependent epilepsy and alcoholism. An important gene associated with Status Epilepticus is ENO2 (enolase 2 (gamma, neuronal)), and among its related pathways are Trafficking of GluR2-containing AMPA receptors and ERK Signaling. The drugs amobarbital and amobarbital sodium and the compounds carbachol and acth have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and b cells, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Aliases & Descriptions for Status Epilepticus

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6Disease Ontology, 30NIH Rare Diseases, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

status epilepticus 6 30 32 43
status epilepticus, unspecified (disorder) 6
generalized convulsive status epilepticus 30
status epilepticus, unspecified 6
status epilepticus (disorder) 6
grand mal status epilepticus 43
status epilepticus nos 6
grand mal status 6
gcse 30
se 30

Related Diseases for Status Epilepticus

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13GeneCards, 14GeneDecks
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Diseases related to status epilepticus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 530)
idRelated DiseaseScoreTop Affiliating Genes
1pyridoxine-dependent epilepsy31.8ALDH7A1, GAD1
2alcoholism30.5CNR1, GRIN2B, ABAT, TSPO, NPY, GABBR1
3convulsions30.1BDNF, SCN1A, FOS, GRM5, ENO2, CACNA1A
4myoclonus29.7SERPINI1, ATN1, GFAP, POLG, NHLRC1, GABBR1
5familial hemiplegic migraine29.7SCN1A, CACNA1A, CALCA
6hemiplegic migraine29.5SCN1A, CACNA1A, CALCA
7insulin resistance28.4CNR1, CNTF, BDNF, JUN, FOS, IL11
8type 2 diabetes mellitus27.9CNR1, BDNF, BAX, IL6R, CASP9, GH1
9ulcerative colitis27.7LIF, FOS, IL11, IL6R, ABCB1, TACR1
10myocardial infarction27.6CNR1, CNTF, BDNF, BAX, IL11, IL6R
11diabetes mellitus27.5CNR1, BDNF, BAX, JUN, GRIA3, IL6R
12dermatitis27.5CNR1, LIF, LIFR, BDNF, JUN, IL6ST
13glioblastoma27.4BCL2L1, LGI1, BAX, CD44, ABCC1, GFAP
14pick's disease27.3CNP, BDNF, CASP3, TUBB3, ACHE, TSPO
15b-cell lymphomas27.3CNR1, BCL2L1, BAX, CD44, CASP3, CASP9
16psoriasis27.1CNR1, LIF, BCL2L1, BAX, JUN, IL11
17osteoporosis26.9CNR1, LIF, JUN, CD44, FOS, IL11
18cystic fibrosis26.9BAX, JUN, IL6R, CASP3, CAMK2G, CALCA
19crohn's disease26.8CNR1, BCL2L1, ATN1, JUN, CD44, IL11
20tuberculosis26.6LGI1, BAX, ATN1, JUN, CD9, IL11
21chronic myeloid leukemia26.5BCL2L1, IL11, CASP3, CAMK2G, CASP9, ABCB1
22obesity26.5CNR1, CNTF, LIF, BDNF, JUN, CD44
23mood disorder26.5CNR1, BDNF, TACR1, POLG, NPY, ADORA1
24blindness26.5CNGB1, CNR1, CNTF, LIF, SCN1A, CD9
25rheumatoid arthritis26.4CNR1, CNTF, LIF, BDNF, BAX, JUN
26hepatitis c26.4CNR1, CNTF, BCL2L1, BAX, JUN, CD9
27major depressive disorder26.3CNR1, BDNF, GRIN2B, NTRK2, ABCB1, TACR1
28contact dermatitis26.3CNR1, LIF, ENO2, CALCA, TACR1, GAP43
29eating disorder26.3CNR1, BDNF, NTRK2, NPY
30drug dependence26.2CNR1, BDNF, FOS, CAMK2G, TSPO, NPY
31hepatitis b26.2LIF, LIFR, BCL2L1, BAX, JUN, CD44
32vascular dementia26.1BDNF, ACHE, GFAP, DCX, NPY
33diabetic retinopathy26.0CNR1, SERPINI1, JUN, GFAP, OSM, NPY
34asthma26.0CNR1, LIF, LIFR, BDNF, BAX, JUN
35multiple myeloma26.0BCL2L1, CD44, ABCB1
36cholangiocarcinoma26.0BCL2L1, BAX, CD44, IL6R, IL6ST, CASP3
37hypothyroidism25.9CNP, LIF, FOS, CASP3, CALCA, GH1
38congestive heart failure25.9JUN, IL6R, IL6ST, CALCA, ABCB1, NPY
39periodontitis25.8CNR1, SERPINI1, BDNF, JUN, CD44, FOS
40pneumonia25.8LIF, BDNF, ATN1, JUN, CD9, ASCL1
41allergic rhinitis25.8BDNF, JUN, CALCA, CYP3A4, TACR1, OSM
42rhinitis25.7BDNF, JUN, CALCA, CYP3A4, TACR1, OSM
43congenital heart defect25.7CNR1, LIF, IL6R, IL6ST, CAMK2G, CASP9
44endometrial carcinoma25.7BAX, JUN, CD44, FOS, IL11, CASP3
45carcinoid tumors25.7CD44, ASCL1, ENO2, CALCA, GH1, NPY
46atrial fibrillation25.6IL6R, CASP3, CAMK2G, ACHE, TSPO, NPY
47aldosteronism25.6JUN, GRM3, CASP3, CAMK2G, GH1, ABCB1
48myelodysplastic syndrome25.5BAX, FOS, IL11, CASP3, CALCA, CYP3A4
49oral lichen planus25.5BAX, CD44, CASP3, CALCA, TACR1, NPY
50lichen planus25.4BAX, JUN, CD44, CASP3, CALCA, TACR1

Graphical network of the top 20 diseases related to status epilepticus:



Graphical network of diseases related to status epilepticus

Clinical Features for Status Epilepticus

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Drugs & Therapeutics for Status Epilepticus

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 amobarbital, amobarbital na pwdr [va product], amobarbital sodium, diazepam, etomidate, fosphenytoin, fosphenytoin sodium, lorazepam, midazolam, midazolam hydrochloride, pentobarbital, pentobarbital na pwdr [va product], pentobarbital sodium, propofol

Genetic Tests for Status Epilepticus

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Anatomical Context for Status Epilepticus

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22MalaCards
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MalaCards organs/tissues related to status epilepticus:

22
Brain, Breast, B cells, Temporal lobe

Phenotypes for genes affiliated with Status Epilepticus

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25MGI
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MGI Mouse Phenotypes related to status epilepticus:

25 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1taste/olfaction phenotypeMP:00053949.8GAD1, CASP9, CASP3, ENO2, BDNF, CNR1
2endocrine/exocrine gland phenotypeMP:00053799.7PROX1, TYRO3, OTC, GRM5, ASCL1, ATN1
3respiratory system phenotypeMP:00053889.5GAD1, ADORA1, ACHE, CALCA, CACNA1A, ASCL1
4hematopoietic system phenotypeMP:00053979.4POLG, DFFB, TYRO3, OTC, CASP9, CACNA1A
5liver/biliary system phenotypeMP:00053709.4SLC25A13, PROX1, ABCB1, OTC, GH1, LIF
6adipose tissue phenotypeMP:00053758.6PROX1, POLG, NPY, GABBR1, ACHE, GH1
7hearing/vestibular/ear phenotypeMP:00053778.2POLG, ACHE, ABCB1, NTRK2, CALCA, CASP3
8immune system phenotypeMP:00053878.1OTC, ABCC1, GFAP, TYRO3, DFFB, PROX1
9skeleton phenotypeMP:00053907.6CASP3, CALCA, TYRO3, TACR1, POLG, SLC18A3
10vision/eye phenotypeMP:00053917.5IL6ST, CASP3, NTRK2, ACHE, GFAP, TYRO3
11no phenotypic analysisMP:00030127.5ACHE, HCN1, DCX, POLG, SLC18A3, SLC25A13
12normal phenotypeMP:00028736.9CACNA1A, SPAST, NTRK2, HCN1, GFAP, PROX1
13mortality/agingMP:00107686.9GAP43, GAD1, CNGB1, CACNA1A, ALDH5A1, IL6ST
14reproductive system phenotypeMP:00053896.8CAMK2G, GH1, OTC, SPAST, ACHE, HCN2
15cellular phenotypeMP:00053846.2GFAP, ABCC5, ABCB1, NTRK2, OTC, TUBB3
16integument phenotypeMP:00107715.7JUN, CD44, FOS, ASCL1, GRIA1, GRIA2
17nervous system phenotypeMP:00036313.9GAP43, HCN2, HCN1, ACHE, ABCC1, NTRK2
18homeostasis/metabolism phenotypeMP:00053763.7GAD1, GFAP, ACHE, ABCC1, ABCB1, NTRK2
19growth/size phenotypeMP:00053783.5SLC25A13, GH1, CASP9, CACNA1A, CASP3, ALDH5A1
20behavior/neurological phenotypeMP:00053863.3GABRA4, GAD1, GABBR2, GABBR1, ADORA1, CNP

Publications for genes affiliated with Status Epilepticus

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35PubMed
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Articles related to status epilepticus:

(show top 50)    (show all 59)
idTitleAuthorsYearAffiliating Genes
1Polysialic acid affects pathophysiological consequenc es of status epilepticus. (20351597)Pekcec A.... Potschka H.2010ST8SIA4
2Effect of recombinant human erythropoietin on hippoc ampal p-Akt and caspase-9 expressions in rats with status epilepticus and the m echanism (20117987)Wang W.P.... Zang Y.Z.2010CASP9
3Transcriptome analysis of the hippocampal CA1 pyramid al cell region after kainic acid-induced status epilepticus in juvenile rats. (20505763)LaurAcn H.B.... Holopainen I.E.2010PCP4
4Granulocyte colony-stimulating factor treatment preve nts cognitive impairment following status epilepticus in rats. (20410588)Zhang Y.... Huang Y.2010CASP3, BCL2L1, BAX
522-year-old girl with status epilepticus and progress ive neurological symptoms. (19744044)Striano P.... Minassian B.A.2009NHLRC1
6A case of adult-onset type II citrullinemia with rep eated nonconvulsive status epilepticus (19928687)Funabe S.... Hattori N.2009SLC25A13
7Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus. (19055492)Kuteykin-Teplyakov K.... LAPscher W.2009ABCC1, ABCB1, ABCC5
8Status epilepticus in children with Alpers' disease c aused by POLG1 mutations: EEG and MRI features. (19054397)Wolf N.I.... Bast T.2009POLG
9Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: An initial event in neuronal injury induction. (18511210)Unsain N.... Masco D.H.2008NTRK2
10Refractory, life-threatening status epilepticus in a 3-year-old girl. (18275929)Striano P.... Zara F.2008SCN1A
11Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. (18603412)Mikati M.A.... Dbaibo G.2008CASP3, BAX
12Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats. (18397293)Powell K.L.... Reid C.A.2008HCN2, HCN1, CNGB1
13Neuroserpin mutation causes electrical status epilepticus of slow-wave sleep. (18591508)Coutelier M.... Godfraind C.2008SERPINI1
14Pharmacokinetics of midazolam and metabolites in a pa tient with refractory status epilepticus treated with extraordinary doses of mi dazolam. (18223475)Bodmer M.... KrAohenbA1hl S.2008CYP3A4
15Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus. (18394802)Guidine P.A.... Moraes M.F.2008SLC18A3
16Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. (18294203)Uusimaa J.... Majamaa K.2008POLG
17Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness. (19294602)Kluger G.... Plecko B.2008ALDH7A1
18Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. (18760905)Bankstahl J.P.... LAPscher W.2008ABCB1
19Enhanced astrocytic Ca2+ signals contribute to neuron al excitotoxicity after status epilepticus. (17913901)Ding S.... Haydon P.G.2007GRM5
20Histone modifications in status epilepticus induced b y kainate. (16598677)Taniura H.... Yoneda Y.2006FOS, JUN
21Age-related electrical status epilepticus during sleep and epileptic negative myoclonus in DRPLA. (16534126)Kobayashi K.... Ohtsuka Y.2006ATN1
22Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. (16469864)Blair R.E.... DeLorenzo R.J.2006CNR1
23Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms. (16240371)Wu Y.... Snead O.C.2006ALDH5A1
24Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. (16828199)Ma D.L.... Tang F.R.2006SPAST
25Altered expression of GABA(A) and GABA(B) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. (15951123)Nishimura T.... Sperk G.2005GABBR2
26Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. (16190927)van Vliet E.A.... Gorter J.A.2005ABCC1
27Hypercalcemia and status epilepticus relates to salmon calcitonin administration in breast cancer. (16143533)Chung S.Y.... Chen W.H.2005CALCA
28Latency to onset of status epilepticus determines molecular mechanisms of seizure-induced cell death. (14969739)Kondratyev A.... Gale K.2004DFFB
29Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus. (15246118)Tang F.R.... Ling E.A.2004GRM3, GRM2
30New CACNA1A gene mutation in a case of familial hemiplegic migraine with status epilepticus. (15240985)Beauvais K.... Furby A.2004CACNA1A
31Malnutrition increases hippocampal neurogenesis in the immature rat after status epilepticus (14761318)Wang Y.L.... Wang J.W.2003GFAP, TUBB3
32Widespread upregulation of drug-resistance proteins in fatal human status epilepticus. (12558585)Sisodiya S.M.... Thom M.2003ABCC1
33Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation. (14614900)Rosell D.R.... McEwen B.S.2003IL6R, IL6ST, LIF
34Non-convulsive status epilepticus in two patients rec eiving tiagabine add-on treatment. (11284127)Skodda S.... Gehlen W.2001GABBR1
35Differential regulation of basic helix-loop-helix mRNAs in the dentate gyrus following status epilepticus. (11564418)Elliott R.C.... Lowenstein D.H.2001ASCL1, PROX1
36Late onset heterozygous ornithine transcarbamylase deficiency mimicking complex partial status epilepticus. (11080238)Bogdanovic M.D.... Land J.M.2000OTC
37Serum neuron-specific enolase in the major subtypes of status epilepticus. (10078721)DeGiorgio C.M.... Correale J.1999ENO2
38Substance P is expressed in hippocampal principal neu rons during status epilepticus and plays a critical role in the maintenance of status epilepticus. (10220458)Liu H.... Wasterlain C.G.1999TACR1
39Paradoxical GH response to TRH during status epilepticus in man. (10097249)Lindbom U.... Tomson T.1999GH1
40Electrocorticographic changes during generalized conv ulsive status epilepticus in soman intoxicated rats. (9600547)Koplovitz I.... Skvorak J.P.1998ACHE
41Selective reduction of GluR2 protein in adult hippocampal CA3 neurons following status epilepticus but prior to cell loss. (9825961)Friedman L.K.1998GRIA2, GRIA1
42Non-convulsive status epilepticus induced by antidepressants. (9663805)Miyata H.... Kifune A.1997ENO2
43Serum NSE in status epilepticus. (8649598)Schmitt B.... Bandtlow C.1996ENO2
44Serum neuron-specific enolase in human status epilepticus. (7783877)DeGiorgio C.M.... Rabinowicz A.L.1995ENO2
45Neuronal injury following electrically induced status epilepticus with and without adenosine receptor antagonism. (7649219)Young D.... Dragunow M.1995ADORA1
46Atypical presentation of carnitine palmitoyltransferase (CPT) deficiency as status epilepticus. (7751848)Shintani S.... Sugiyama N.1995CPT1B
47Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. (8162392)Steinhoff B.J.... Stodieck S.R.1993TSPO
48Previous dissociative psychiatric disorder and status epilepticus in a case of acute HIV infection (1504207)Arias Mayorga J.... MaraA+A^n Cabello A.1992CD9
49Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat. (1319899)Perlin J.B.... DeLorenzo R.J.1992CAMK2G
50Neuropathologic asymmetries in the brain of a patient with a unilateral status epilepticus. (1715386)Leifer D.... Kowall N.W.1991CALB1

Expression for genes affiliated with Status Epilepticus

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Status Epilepticus

Pathways for genes affiliated with Status Epilepticus

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38Reactome, 36QIAGEN, 34PharmGKB, 20KEGG, 41Thomson Reuters, 10EMD Millipore, 3Cell Signaling Technology
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Pathways related to status epilepticus according to GeneDecks:

(show top 50)    (show all 76)
idPathwayScoreTop Affiliating Genes
1Trafficking of GluR2-containing AMPA receptors3810.3GRIA3, GRIA2, GRIA1
2ERK Signaling3610.2OSM, TYRO3, CACNA1A, IL11, LIFR
3Sympathetic Nerve Pathway (Neuroeffector Junction)3410.1SLC18A3, NPY, ACHE, CACNA1A
4Neuronal System3810.1GABRA4, SLC18A3, HCN2, HCN1, ABAT, ALDH5A1
5Endothelin-1 Signaling Pathway3610.1OSM, TYRO3, NTRK2, CASP3, IL11, LIFR
6JNK Pathway3610.0TYRO3, NTRK2, IL6R, JUN, BAX, LIFR
7Colorectal cancer2010.0FOS, CASP9
8Akt Signaling3610.0GABRA4, OSM, CASP9, IL6R, IL11, LIFR
9Immune response_Oncostatin M signaling via MAPK in human cells4110.0OSM, IL6ST, FOS, JUN, LIFR
10Immune response Oncostatin M signaling via MAPK in human cells1010.0OSM, IL6ST, FOS, JUN, LIFR
11Immune response IL-6 signaling pathway109.9IL6ST, IL6R, FOS
12Immune response_IL-6 signaling pathway419.9IL6ST, IL6R, FOS, JUN
13Apoptosis and survival Role of CDK5 in neuronal death and survival109.9CASP9
14Development_CNTF receptor signaling419.8FOS, LIFR, CNTF
15Apoptosis and survival_Caspase cascade419.8DFFB, CASP9, CASP3, BAX
16UVA-Induced MAPK Signaling369.8CASP3, FOS, JUN, BCL2L1
17Apoptosis and survival Caspase cascade109.8DFFB, CASP9, CASP3, BAX
18Jak-STAT signaling pathway209.7OSM, GH1, IL6ST, IL6R, IL11, BCL2L1
19Cytokine-cytokine receptor interaction209.7OSM, GH1, IL6ST, IL6R, IL11, LIFR
20Calcium channels109.7CACNA1A, GRIN2B, GRIA3, GRIA2, GRIA1
21Signaling Involved in Cardiac Hypertrophy369.6NTRK2, CACNA1A, IL6ST, IL11, JUN, LIFR
22Development CNTF receptor signaling109.6IL6ST, FOS, LIFR, CNTF
23Long-term depression209.6CACNA1A, GRM5, GRIA3, GRIA2, GRIA1
24MIF Regulation of Innate Immune Cells369.6OSM, IL11, FOS, JUN, BAX, LIF
25Apoptosis and survival_Role of CDK5 in neuronal death and survival419.5CASP9, CASP3, JUN, BAX
26Apoptosis209.4BCL2L1, BAX, CASP3, CASP9, DFFB
27Long-term potentiation209.4CAMK2G, GRM5, GRIN2B, GRIA2, GRIA1
28PAK Pathway369.3OSM, GH1, CASP9, CASP3, IL11, BAX
29Glutamic acid signaling109.3GAD1, GRM5, GRM3, GRM2, GRIN2B, GRIA3
30Vinka Alkaloid Pathway, Pharmacokinetics349.3ABCC1, ABCB1, CYP3A4, BAX
31Mitochondrial Apoptosis369.2NTRK2, GH1, CASP9, CASP3, BAX, BCL2L1
32DHA Signaling369.2NTRK2, GH1, CASP9, CASP3, BAX, BCL2L1
33Transcription_Role of VDR in regulation of genes involved in osteoporosis419.2JUN, FOS, CALB1, CALCA, CYP3A4
34Transcription Role of VDR in regulation of genes involved in osteoporosis109.2CYP3A4, CALCA, CALB1, FOS, JUN
35Cellular Apoptosis Pathway369.2NTRK2, GH1, CASP9, CASP3, BAX, BCL2L1
36Amyotrophic lateral sclerosis (ALS)209.1CASP9, CASP3, GRIN2B, GRIA2, GRIA1, BAX
37Glutamatergic synapse209.1CACNA1A, GRM5, GRM3, GRM2, GRIN2B, GRIA3
38p38 Signaling369.1GH1, NTRK2, TYRO3, OSM, CASP3, IL6R
39PEDF Induced Signaling369.1OSM, IL11, GRIN2B, FOS, BAX, BCL2L1
40JAK-STAT Pathway369.0TYRO3, NTRK2, GH1, IL6R, IL11, FOS
41Pathogenesis of ALS369.0CASP9, CASP3, GRIN2B, GRIA3, GRIA2, GRIA1
42ILK Signaling369.0TYRO3, NTRK2, GH1, CASP9, FOS, JUN
43CREB Pathway368.9NTRK2, GH1, CACNA1A, GRM5, GRM3, GRM2
44Intracellular Calcium Signaling368.9TYRO3, NTRK2, GH1, CACNA1A, GRIN2B, GRIA3
45Antioxidant Action of Vitamin-C368.9OSM, NTRK2, GH1, IL6R, IL11, FOS
46Rho Family GTPases368.7GH1, NTRK2, GFAP, TYRO3, OSM, IL11
47Neuroscience38.5CNP, GAP43, GAD1, GABBR2, GABBR1, DCX
48Molecular Mechanisms of Cancer368.2CAMK2G, GH1, TUBB3, NTRK2, TYRO3, OSM
49Neuropathic Pain-Signaling in Dorsal Horn Neurons368.2TACR1, NTRK2, CAMK2G, GRM5, GRM3, GRM2
50Neuroactive ligand-receptor interaction207.9TSPO, TACR1, ADORA1, GABBR1, GABBR2, GABRA4

Compounds for genes affiliated with Status Epilepticus

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32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
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Compounds related to status epilepticus according to GeneDecks:

(show top 50)    (show all 297)
idCompoundScoreTop Affiliating Genes
1carbachol32 9 9 12.4ADORA1, IL11
2acth32 10.0LIFR, BDNF, GFAP, OSM, NPY, GAP43
3glucose32 9.9GABBR1, CALB1, IL11, GRM3, CNTF, OTC
4baclofen32 9 9 11.8GAD1, GABBR2, GABBR1, NPY, TSPO, CNR1
5morphine32 9 9 11.7GFAP, CNR1, TSPO, TACR1, GABBR1, CAMK2G
6choline32 9 18 9 12.5CALB1, BDNF, CNTF, LIF, ENO2, SLC18A3
75-hydroxytryptamine32 9.4ENO2, ADORA1, GABBR1, NPY, TACR1, TSPO
8quinolinic acid32 18 10.3CNTF, BDNF, CD9, CALB1, NTRK2, GFAP
9tetrodotoxin32 9.3CNR1, ACHE, NTRK2, CALCA, CAMK2G, CALB1
10alanine32 9.1GFAP, TACR1, OSM, POLG, NPY, ADORA1
11haloperidol32 34 9 9 12.1BDNF, NPY, TACR1, ABCB1, GRM5, GAD1
12pentobarbital32 9 9 11.0GRIA1, GABBR1, GFAP, CYP3A4, GRIA3, GRIA2
13alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid32 9.0GABBR1, TACR1, CAMK2G, GRM5, GRIA3, GRIA2
14estrogen32 8.9TSPO, GH1, TUBB3, IL11, IL6ST, CALB1
15glutamine32 8.7ALDH5A1, NPY, IL11, IL6R, ENO2, CACNA1A
16aspartate32 8.7CNR1, GFAP, BDNF, GAP43, ADORA1, SLC25A13
17depsipeptide32 8.6BCL2L1, OSM, ABCC1, ABCB1, CASP9, CASP3
18norepinephrine32 9 18 9 11.6GAP43, GABBR1, ADORA1, NPY, TACR1, TSPO
19potassium32 9 18 9 11.5CAMK2G, LIF, BDNF, NTRK2, GAD1, CALB1
20vinblastine32 9 9 10.4BCL2L1, BDNF, BAX, JUN, CYP3A4, NTRK2
21acetylcholine32 9 18 9 11.4CALCA, CAMK2G, CACNA1A, CALB1, ENO2, BDNF
22etoposide32 42 9 9 11.3BCL2L1, BAX, JUN, CD44, CASP3, NTRK2
23atp32 8.2SPAST, ABCB1, ABCC1, ABCC5, GFAP, DFFB
24cytarabine32 34 9 9 11.1CASP3, IL11, JUN, BAX, BCL2L1, LIF
25pd 98,05932 7.9ENO2, GFAP, CNTF, LIF, BDNF, BCL2L1
26adenylate32 7.9FOS, CD44, BDNF, CNTF, POLG, CNR1
27oligonucleotide32 7.9LIF, CAMK2G, GH1, LIFR, FOS, CD9
28forskolin32 42 9 9 10.7CNP, CNTF, LIF, BDNF, JUN, FOS
29cyclic amp32 18 8.7GFAP, HCN2, HCN1, NTRK2, TACR1, NPY
30nitric oxide32 9 18 9 10.6ABAT, LIF, NTRK2, TACR1, OSM, NPY
31ethanol32 34 9 18 9 11.6IL6R, IL11, GRM5, GRIN2B, BDNF, CAMK2G
32cisplatin32 34 9 9 10.6TUBB3, NTRK2, ABCC1, ABCC5, GFAP, TACR1
33gaba32 42 8.5CAMK2G, GRIA1, BDNF, CNTF, CNR1, GRIA3
34genistein32 9 18 9 10.4GFAP, CNTF, LIF, BAX, JUN, CASP3
35cocaine32 9 9 9.4CNR1, CNTF, BDNF, GRIA2, GRIA1, FOS
36paclitaxel32 34 9 9 10.1ABCC1, ABCB1, CYP3A4, TUBB3, CASP9, CASP3
37actinomycin d32 7.1ABCC1, ABCB1, GH1, CASP9, CAMK2G, CNTF
38vegf32 7.0ENO2, CASP3, BDNF, IL6R, IL6ST, CAMK2G
39cycloheximide32 7.0NTRK2, IL11, CD44, CNTF, BAX, BCL2L1
40kainate32 6.8GRIN2B, GRM5, GRM3, GRM2, GRIA3, GRIA2
41phosphatidylinositol32 6.7GRIN2B, IL11, FOS, CD9, CD44, JUN
42testosterone32 9 18 9 9.7ENO2, CNTF, IL6R, ATN1, BDNF, GH1
43dopamine32 9 18 9 9.6CNTF, LIF, BDNF, FOS, ASCL1, GRIA1
44nmda32 42 7.5BDNF, BCL2L1, FOS, GRIA1, GRIA2, GRIA3
45dexamethasone32 42 34 9 9 10.4CYP3A4, ABCB1, GFAP, TACR1, OSM, ADORA1
46glutamate32 6.3ALDH5A1, CALB1, CACNA1A, CAMK2G, CALCA, CASP9
47calcium32 9 18 9 8.7GAD1, GAP43, CNGB1, CNR1, CNTF, PCP4
48retinoic acid32 42 18 7.6OSM, NPY, SLC18A3, GAP43, IL6R, IL6ST
49tyrosine32 5.5CNTF, LIFR, BDNF, BCL2L1, ATN1, JUN
50serine32 5.1ACHE, ABAT, NTRK2, GH1, CASP9, CAMK2G

GO Terms for genes affiliated with Status Epilepticus

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Sources:
12Gene Ontology
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Cellular components related to status epilepticus according to GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1dendritic shaftGO:04319810.2GABBR1, HCN2, GRIA3, GRIA2
2asymmetric synapseGO:03227910.1GRIA2, GRIA3, ADORA1
3alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complexGO:0322819.8GRIA3, GRIA2, GRIA1
4presynaptic membraneGO:0427349.8GABBR1, ADORA1, GRM3, GRM2, GRIN2B, GRIA2
5synaptic cleftGO:0430839.8GRIA3, GRIN2B, ACHE
6endocytic vesicle membraneGO:0306669.8GRIA1, GRIA2, GRIA3, CAMK2G
7perikaryonGO:0432049.7CACNA1A, ENO2, GRIA3, GRIA2
8terminal buttonGO:0431959.6ADORA1, NTRK2, CALCA, GRIN2B, GRIA3, GRIA2
9axonGO:0304249.6GAP43, HCN2, HCN1, TUBB3, CALB1, GRM3
10neuronal cell bodyGO:0430259.3GABBR1, ADORA1, HCN2, NTRK2, CALCA, CALB1
11dendriteGO:0304259.2DCX, TACR1, HCN1, CACNA1A, CALB1, IL6ST
12postsynaptic densityGO:0140699.2ADORA1, NTRK2, GRM3, GRIN2B, GRIA3, GRIA2
13postsynaptic membraneGO:0452118.8GABRA4, GABBR2, GABBR1, ADORA1, GRM3, GRIN2B
14cell junctionGO:0300548.7GABRA4, GAP43, GABBR2, GABBR1, ACHE, GRIN2B
15integral to plasma membraneGO:0058877.0CNR1, TYRO3, TACR1, SLC18A3, SLC25A13, ADORA1
16plasma membraneGO:0058864.9HCN1, ACHE, ABCC5, ABCC1, ABCB1, CAMK2G

Biological processes related to status epilepticus according to GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1leukemia inhibitory factor signaling pathwayGO:04886110.5LIF, LIFR, IL6ST
2ciliary neurotrophic factor-mediated signaling pathwayGO:07012010.4IL6ST, IL6R, LIFR, CNTF
3central nervous system developmentGO:00741710.4GABRA4, DCX, ALDH5A1, ATN1, SERPINI1, PCP4
4behaviorGO:00761010.4NPY, TACR1, ABAT, CNR1
5response to nicotineGO:03509410.4CNR1, ABAT, TACR1, GABBR1
6central nervous system neuron developmentGO:02195410.3ASCL1, NTRK2, NPY
7negative regulation of hormone secretionGO:04688810.3LIF, IL11, OSM, ADORA1
8negative regulation of blood pressureGO:04577610.3ADORA1, NPY, ABAT, CALCA, CNR1
9feeding behaviorGO:00763110.3NPY, NTRK2, CALCA, BDNF
10gamma-aminobutyric acid catabolic processGO:00945010.3ABAT, ALDH5A1
11neurotransmitter secretionGO:00726910.3ALDH5A1, ABAT, SLC18A3, GAD1
12response to fungicideGO:06099210.2GRIA2, GRIA3, GRIN2B
13glutamate secretionGO:01404710.2NTRK2, GRM2, BDNF
14agingGO:00756810.2TSPO, HCN2, CALCA, JUN, CNR1
15positive regulation of anti-apoptosisGO:04576810.2LIFR, BCL2L1, IL6R, IL6ST
16release of cytochrome c from mitochondriaGO:00183610.1CASP3, JUN, BAX, BCL2L1
17positive regulation of MAPK cascadeGO:04341010.1OSM, NTRK2, IL6R, IL11, LIF, CNTF
18positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.1GH1, IL6ST, IL6R, LIF, CNTF
19negative regulation of adenylate cyclase activityGO:00719410.0GABBR2, GABBR1, GRM3, GRM2
20gamma-aminobutyric acid signaling pathwayGO:00721410.0GABRA4, GABBR2, GABBR1, CACNA1A
21response to ethanolGO:0454719.9GABBR1, TACR1, ABAT, GRIN2B, CNR1
22activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:0086359.9BAX, CASP3, CASP9
23positive regulation of neuron apoptotic processGO:0435259.9CASP9, CASP3, ASCL1, JUN, BAX
24behavioral response to painGO:0482669.9OSM, TACR1, TSPO, CACNA1A, GRIN2B
25response to cytokine stimulusGO:0340979.9IL6ST, IL6R, GRIN2B, JUN, BCL2L1, LIFR
26nervous system developmentGO:0073999.9ADORA1, DCX, ST8SIA4, ACHE, SPAST, CAMK2G
27vestibular nucleus developmentGO:0217509.9CACNA1A, ASCL1
28cerebral cortex developmentGO:0219879.9NPY, NTRK2, GRIN2B, ASCL1, BAX
29nuclear fragmentation involved in apoptotic nuclear changeGO:0302649.9CASP3, BAX
30response to woundingGO:0096119.8GFAP, ACHE, CASP3, GAP43
31response to drugGO:0424939.8GAD1, TSPO, HCN2, ABCC1, ABCB1, ABAT
32positive regulation of peptidyl-serine phosphorylationGO:0331389.7OSM, IL11, CD44, LIF
33negative regulation of neuron apoptotic processGO:0435249.7TYRO3, NTRK2, CACNA1A, JUN, BAX, BCL2L1
34induction of apoptosis by intracellular signalsGO:0086299.6CASP9, CASP3, BAX, BCL2L1
35positive regulation of cell proliferationGO:0082849.6PROX1, OSM, NTRK2, IL6ST, IL6R, IL11
36positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4OSM, GH1, IL6R, IL11, CD44, LIF
37transportGO:0068109.4GABRA4, SLC25A13, ABCC5, ABCC1, ABCB1, GRIN2B
38synaptic transmissionGO:0072687.1CNP, ACHE, HCN1, HCN2, NPY, SLC18A3

Molecular functions related to status epilepticus according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ciliary neurotrophic factor receptor activityGO:00489710.4IL6ST, IL6R, LIFR
2ciliary neurotrophic factor receptor bindingGO:00512710.4IL6ST, LIFR, CNTF
3interleukin-6 receptor bindingGO:00513810.3IL6ST, IL6R, CNTF
4calcium channel regulator activityGO:00524610.3NPY, GRM3, GRM2
5group II metabotropic glutamate receptor activityGO:00164110.2GRM2, GRM3
6interleukin-6 bindingGO:01998110.2IL6R, IL6ST
7alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityGO:00497110.2GRIA3, GRIA2, GRIA1
8interleukin-6 receptor activityGO:00491510.1IL6R, IL6ST
9leukemia inhibitory factor receptor activityGO:00492310.0LIFR, IL6ST
10extracellular-glutamate-gated ion channel activityGO:0052349.8GRIA1, GRIA2, GRIA3, GRIN2B
11growth factor activityGO:0080839.7OSM, GH1, IL11, BDNF, LIF, CNTF
12glutamate receptor activityGO:0080669.7GRIA1, GRIA2, GRM2, GRM3, GRM5
13protein homodimerization activityGO:0428039.3ACHE, ABAT, NTRK2, ALDH5A1, ENO2, IL6ST
14protein bindingGO:0055154.9CASP9, EXOSC3, GH1, SPAST, ABCB1, ACHE

Sources for Status Epilepticus

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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