SE
MCID: STT001
MIFTS: 64

Status Epilepticus (SE) malady

Neuronal category

Summaries for Status Epilepticus

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Status epilepticus (SE) is a life-threatening condition in which the brain is in a state of persistent... more...

MalaCards: Status Epilepticus, also known as generalized convulsive status epilepticus, is related to temporal lobe epilepsy and limbic encephalitis. An important gene associated with Status Epilepticus is POLG (polymerase (DNA directed), gamma), and among its related pathways are N-cadherin signaling events and Glutamic acid signaling. The drugs amobarbital and diazepam and the compounds bicuculline and baclofen have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and bone marrow, and related mouse phenotypes are no phenotypic analysis and normal.

Aliases & Classifications for Status Epilepticus

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

status epilepticus 8 43 45 61
generalized convulsive status epilepticus 43
status epilepticus, unspecified 8
grand mal status epilepticus 61
status epilepticus nos 8
grand mal status 8
gcse 43
se 43


External Ids:

Disease Ontology8 DOID:1824
NCIt40 C85079
MeSH35 D013226
ICD1025 G41, G41.0, G41.9

Related Diseases for Status Epilepticus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 736)
idRelated DiseaseScoreTop Affiliating Genes
1temporal lobe epilepsy30.7BDNF, CALB1, NPY, GAD1, LGI1
2limbic encephalitis30.5GAD1
3central hypoventilation syndrome, congenital, with or without hirschsprung disease30.1BDNF, ASCL1
4febrile seizures30.1LGI1, NPY
5insulin resistance30.0CNR1, NPY
6hypoglycemia29.9POLG, GAD1, NPY, BDNF
7ganglioglioma29.9ENO2, DCX
8memory impairment29.9CNR1, GAP43, CALB1, BDNF
9bipolar disorder29.9BDNF, CALB1, GAP43, GAD1, POLG, CNR1
10parkinson's disease29.9BDNF, CALB1, GAP43, GAD1, POLG, CNR1
11adenocarcinoma29.8BDNF, DFFB, CNR1, ENO2, ASCL1
12n syndrome10.5
13neurosyphilis10.5
14brain injury10.3
15arthritis10.3
16juvenile myoclonic epilepsy10.3
17pyridoxine-dependent epilepsy10.3
18lennox-gastaut syndrome10.2
19cadasil10.2
20landau-kleffner syndrome10.2
21acute intermittent porphyria10.2
22acute porphyria10.2
23polymicrogyria10.2
24febrile infection-related epilepsy syndrome10.2
25alpers syndrome10.2
26melas syndrome10.2
27dravet syndrome10.2
28cortical blindness10.2
29hemimegalencephaly10.2
30thanatophoric dysplasia type 110.2
31myoclonus10.2
32blindness10.2
33subacute sclerosing panencephalitis10.1
34angelman syndrome10.1
35pulmonary edema10.1
36wolf-hirschhorn syndrome10.1
37brain edema10.1
38hypertensive encephalopathy10.1
39thrombotic thrombocytopenic purpura10.1
40hypercalcemia10.1
41neuroleptic malignant syndrome10.1
42methylmalonic aciduria and homocystinuria type cblf10.1
43metabolic acidosis10.1
44systemic scleroderma10.1
45vasculitis10.1
46fryns syndrome10.1
47retinal vasculopathy with cerebral leukodystrophy10.1
48schindler disease, type 110.1
49cockayne syndrome type ii10.1
50sialidosis type i10.1

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to status epilepticus

Clinical Features for Status Epilepticus

Drugs & Therapeutics for Status Epilepticus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Status Epilepticus

Drug clinical trials:

Search ClinicalTrials for Status Epilepticus

Search NIH Clinical Center for Status Epilepticus

Search CenterWatch for Status Epilepticus

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Status Epilepticus

Anatomical Context for Status Epilepticus

Sources:
33MalaCards
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MalaCards organs/tissues related to Status Epilepticus:

33
Skin, Brain, Bone marrow, Whole blood, Cortex, Cerebellum, Heart, Breast, Monocytes, B cells, Endothelial, Temporal lobe, Thalamus, Amygdala, Pituitary

Animal Models for Status Epilepticus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Status Epilepticus

Sources:
51PubMed
See all sources

Articles related to Status Epilepticus:

(show top 50)    (show all 685)
idTitleAuthorsYear
1
A girl with Cardio-facio-cutaneous syndrome complicated with status epilepticus and acute encephalopathy. (23340054)
2014
2
Clinical experience with intravenous valproate as first-line treatment of status epilepticus and seizure clusters in selected populations. (23777558)
2014
3
Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy? (23266599)
2013
4
Subclinical epileptiform activity in children with electrical status epilepticus during sleep: effects on cognition and behavior before and after treatment with levetiracetam. (23376335)
2013
5
Antagomirs and microRNA in status epilepticus. (24001063)
2013
6
ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus. (23535492)
2013
7
A case of recurrent acute encephalopathy with febrile convulsive status epilepticus with carnitine palmitoyltransferase II variation. (23450341)
2013
8
The reverse roles of transient receptor potential canonical channel-3 and -6 in neuronal death following pilocarpine-induced status epilepticus. (22926417)
2013
9
Use of dietary therapy for status epilepticus. (23640913)
2013
10
Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy. (23636891)
2013
11
Status epilepticus as manifestation of posterior reversible encephalopathy syndrome in a healthy child. (23583065)
2013
12
A cupric silver histochemical analysis of domoic acid damage to olfactory pathways following status epilepticus in a rat model for chronic recurrent spontaneous seizures and aggressive behavior. (22821366)
2013
13
SGE-102: a novel therapy for refractory status epilepticus. (24001082)
2013
14
A comparative assessment the efficacy of intravenous infusion of sodium valproate and phenytion in the treatment of status epilepticus. (23776727)
2013
15
The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus. (24042195)
2013
16
Histopathological evidence that hippocampal atrophy following status epilepticus is a result of neuronal necrosis. (23992920)
2013
17
Ketogenic diet in 3 cases of childhood refractory status epilepticus. (23751291)
2013
18
What can we learn from status epilepticus registries? (24001079)
2013
19
Intravenous lacosamide as treatment option in post-stroke non convulsive status epilepticus in the elderly: a proof-of-concept, observational study. (23953988)
2013
20
Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat. (23896573)
2013
21
Hypothermia for pediatric refractory status epilepticus. (23906244)
2013
22
The established status epilepticus trial 2013. (24001084)
2013
23
Syphilitic limbic encephalitis revealed by status epilepticus. (23391954)
2013
24
Status epilepticus: An association with pyrethroid poisoning. (23983421)
2013
25
Status epilepticus associated with the administration of long-acting methylphenidate in a 7-year-old girl. (22388167)
2012
26
Hemimegalencephaly accompanied by myoclonic status epilepticus. (22704019)
2012
27
Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats. (22765917)
2012
28
Differential DNA methylation patterns define status epilepticus and epileptic tolerance. (22302800)
2012
29
Refractory status epilepticus: electroconvulsive therapy as a possible therapeutic strategy. (22877995)
2012
30
Status epilepticus in adults. (22939067)
2012
31
Intramuscular versus intravenous benzodiazepines for status epilepticus. (22591303)
2012
32
Levetiracetam as alternative stage two antiepileptic drug in status epilepticus: a systematic review. (22321334)
2012
33
Neurosurgical therapy for central area status epilepticus. (23098007)
2012
34
Intravenous Lacosamide in refractory nonconvulsive status epilepticus. (22244046)
2012
35
A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus. (22155333)
2012
36
Exposure to nerve agents: from status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. (23000013)
2012
37
Na88(w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. (22943535)
2012
38
Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism]. (20117987)
2010
39
A case of adult-onset type II citrullinemia with repeated nonconvulsive status epilepticus]. (19928687)
2009
40
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
41
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
42
Status epilepticus as an initial manifestation of neurosyphilis: a case report. (16911923)
2006
43
Prosopagnosia following nonconvulsive status epilepticus associated with a left fusiform gyrus malformation. (16777488)
2006
44
Simple partial status epilepticus localized by single-photon emission computed tomography subtraction in chronic cerebral paragonimiasis. (15358959)
2004
45
Gabapentin and propofol for treatment of status epilepticus in acute intermittent porphyria. (14597800)
2003
46
Nonconvulsive status epilepticus complicating neuroleptic malignant syndrome improved by intravenous diazepam. (10831032)
2000
47
Serum neuron-specific enolase in the major subtypes of status epilepticus. (10078721)
1999
48
Landau-Kleffner syndrome (LKS): long-term follow-up and links with electrical status epilepticus during sleep (ESES). (10206525)
1999
49
Serum neuron-specific enolase in human status epilepticus. (7783877)
1995
50
Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? (8326831)
1993

Genetic Variations for Status Epilepticus

Expression for genes affiliated with Status Epilepticus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Status Epilepticus

Search GEO for disease gene expression data for Status Epilepticus.

Pathways for genes affiliated with Status Epilepticus

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 54Reactome, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Status Epilepticus

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Status Epilepticus according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1bicuculline45 2911.8GAD1, GABRA4
2baclofen45 1111.8CNR1, NPY, GAD1
3dnqx45 1111.8GRIA2, BDNF
4axokine4510.8CNR1, BDNF
5quisqualate45 1111.8BDNF, GRIA2, GRM2
6muscimol45 60 2912.8GAD1, GABRA4, NPY, BDNF
7nmda45 2911.8CNR1, GRM2, GAD1, BDNF, GAP43
8forskolin45 50 1112.7NPY, ENO2, GRM2, GAP43
9quinolinic acid45 2411.7BDNF, GAD1, CALB1
10catecholamine4510.7GAP43, NPY, BDNF, ENO2
11cocaine45 1111.7NPY, BDNF, SLC18A3, CNR1, GRIA2, GAP43
12taurine45 60 2412.7CALB1, ENO2, GAD1
13bromodeoxyuridine4510.7ENO2, GAD1, DCX, BDNF, CALB1
14carbachol45 29 1112.7BDNF, NPY, CNR1, GAP43
15valproate4510.7POLG, GAD1, BDNF
16glutamate4510.7GAD1, NPY, CALB1, GRIA2, GRM2, SLC18A3
17spec-t4510.7CNR1, SLC18A3, ENO2
18tetrodotoxin45 60 2912.7CNR1, ENO2, GAD1, GAP43, NPY, CALB1
19norepinephrine45 11 2412.7BDNF, CALB1, NPY, GAP43, CNR1, ENO2
20adenylate4510.7NPY, ENO2, GAP43, POLG, BDNF, CNR1
215-hydroxytryptamine4510.7NPY, CNR1, ENO2, CALB1
22streptozotocin4510.7GAD1, NPY, BDNF
23aspartate4510.7GRM2, ENO2, GAD1, GAP43, BDNF, CNR1
24methamphetamine45 50 1112.6CALB1, BDNF, NPY
25choline45 11 2412.6CALB1, BDNF, NPY, GAP43, GAD1, SLC18A3
26cyclic amp45 2411.6JUN, GRM2, BDNF, NPY, CNR1, HCN2
27potassium45 11 2412.6ENO2, GAD1, CALB1, HCN2, BDNF, LGI1
286-hydroxydopamine4510.6BDNF, GAP43, NPY
29arachidonic acid45 29 11 2413.6CNR1, GAP43, BDNF, CPT1B, GRIA2
30acetylcholine45 50 29 11 2414.6NPY, BDNF, CALB1, GAP43, GAD1, CNR1
31glutamine4510.6NPY, GRIA2, POLG, ENO2, GAD1
32aniracetam29 45 1112.6BDNF, GRIA2
33kainate45 2911.6BDNF, DCX, GRIA2, GRM2, CNR1, GAP43
34mptp4510.6CALB1, BDNF, GAD1
35gaba4510.6GRM2, ENO2, BDNF, CALB1, CNR1, NPY
36acth4510.6GAP43, BDNF, NPY, ENO2
37ibotenic acid4510.6NPY, GAD1
38retinoic acid45 2411.6ASCL1, ENO2, SLC18A3, GAP43, NPY, CALB1
39atp45 2911.6SLC18A3, POLG, DFFB, GAD1, GAP43, CALB1
40glucose4510.5CALB1, NPY, GAD1, CNR1, ENO2, CPT1B
41dopamine45 29 11 2413.5BDNF, CALB1, GAP43, GAD1, GRM2, NPY
42calcium45 50 11 2413.5ENO2, GRM2, GRIA2, DCX, GAD1, GAP43
43tyrosine4510.5GRM2, SLC18A3, GRIA2, GAD1, CALB1, JUN
44nitric oxide45 11 2412.4CALB1, GAP43, GAD1, SLC18A3, ENO2, NPY
45capsaicin45 2911.4NPY, BDNF, CNR1
46sodium45 2411.4ENO2, LGI1, SLC18A3, BDNF, HCN2
47vinblastine45 50 1112.4JUN, NPY, BDNF
48alanine4510.4GAD1, NPY, GAP43, ENO2, CNR1, POLG
49nbqx45 60 2912.3BDNF, GRIA2
50n-acetylaspartate4510.1CALB1, BDNF

GO Terms for genes affiliated with Status Epilepticus

Sources:
16Gene Ontology
See all sources

Cellular components related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.3LGI1, GRM2, GRIA2, GAP43, GABRA4

Biological processes related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:01404710.4GRM2, BDNF
2agingGO:00756810.3JUN, POLG, CNR1
3synaptic transmissionGO:00726810.2SLC18A3, HCN2, GRM2, GRIA2, GAD1, GABRA4
4central nervous system neuron developmentGO:02195410.1ASCL1, NPY

Molecular functions related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel regulator activityGO:00524610.4GRM2, NPY
2glutamate receptor activityGO:00806610.1GRM2, GRIA2

Products for genes affiliated with Status Epilepticus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Status Epilepticus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet