SE
MCID: STT001
MIFTS: 66

Status Epilepticus (SE) malady

Neuronal diseases category

Summaries for Status Epilepticus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Status epilepticus (SE) is a life-threatening condition in which the brain is in a state of persistent... more...

MalaCards: Status Epilepticus, also known as generalized convulsive status epilepticus, is related to encephalitis and temporal lobe epilepsy. An important gene associated with Status Epilepticus is POLG (polymerase (DNA directed), gamma), and among its related pathways are N-cadherin signaling events and Glutamic acid signaling. The drugs amobarbital and lorazepam and the compounds bicuculline and baclofen have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related mouse phenotypes are no phenotypic analysis and normal.

Aliases & Classifications for Status Epilepticus

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

status epilepticus 8 42 44 60
generalized convulsive status epilepticus 42
status epilepticus, unspecified 8
grand mal status epilepticus 60
status epilepticus nos 8
grand mal status 8
gcse 42
se 42


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Disease Ontology8 DOID:1824
NCIt39 C85079
MeSH34 D013226
ICD1025 G41, G41.0, G41.9

Related Diseases for Status Epilepticus

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 721)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis30.8LGI1, CNR1, CALB1
2temporal lobe epilepsy30.7BDNF, CALB1, NPY, GAD1, LGI1
3focal epilepsy30.5DCX, LGI1
4diabetes mellitus30.3JUN, NPY, GAD1, CNR1
5epilepsy syndrome30.2HCN2, POLG, GRM2, GRIA2, DCX, GAD1
6hypertension30.1NPY
7herpes simplex30.1BDNF, CALB1, GAP43, GAD1, POLG
8central hypoventilation syndrome, congenital, with or without hirschsprung disease30.1BDNF, ASCL1
9leukemia30.0JUN, GAP43, CNR1
10migraine29.9CNR1
11hypoglycemia29.9POLG, GAD1, NPY, BDNF
12ganglioglioma29.9ENO2, DCX
13drug dependence29.9CNR1
14multiple sclerosis29.9JUN, BDNF, NPY, GAD1, CNR1
15parkinson's disease29.9BDNF, CALB1, GAP43, GAD1, POLG, CNR1
16hyperglycemia29.9JUN, BDNF, NPY, GAD1
17schizophrenia29.9BDNF, CALB1, NPY, GAP43, GAD1, GRIA2
18bipolar disorder29.9NPY, BDNF
19retinitis29.7DCX
20ischemia29.7BDNF, GAP43, GAD1, DFFB, DCX, GRIA2
21adenocarcinoma29.7BDNF, DFFB, CNR1, ENO2, ASCL1
22neuronitis10.8
23cerebritis10.5
24cat-scratch disease10.3
25juvenile myoclonic epilepsy10.3
26hepatitis10.3
27pyridoxine-dependent epilepsy10.3
28arthritis10.3
29rheumatoid arthritis10.3
30lennox-gastaut syndrome10.2
31cadasil10.2
32landau-kleffner syndrome10.2
33acute intermittent porphyria10.2
34acute porphyria10.2
35idiopathic generalized epilepsy10.2
36porphyria10.2
37polymicrogyria10.2
38febrile infection-related epilepsy syndrome10.2
39alpers syndrome10.2
40melas syndrome10.2
41dravet syndrome10.2
42cortical blindness10.2
43hepatic encephalopathy10.2
44meningitis10.2
45thanatophoric dysplasia type 110.2
46subacute sclerosing panencephalitis10.1
47angelman syndrome10.1
48pulmonary edema10.1
49mucopolysaccharidosis ii10.1
50wolf-hirschhorn syndrome10.1

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to status epilepticus

Clinical Features for Status Epilepticus

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Drugs & Therapeutics for Status Epilepticus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Status Epilepticus

Drug clinical trials:

Search ClinicalTrials for Status Epilepticus

Search NIH Clinical Center for Status Epilepticus

Search CenterWatch for Status Epilepticus

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Status Epilepticus

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Anatomical Context for Status Epilepticus

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32MalaCards
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MalaCards organs/tissues related to Status Epilepticus:

32
Brain, Temporal lobe, Cortex, Amygdala, Bone, Bone marrow, Endothelial, Skin, Pituitary, Monocytes, Breast, Heart, Cerebellum, Thalamus

Animal Models for Status Epilepticus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Status Epilepticus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.3JUN, BDNF, GABRA4, GAD1, DCX, GRIA2
2MP:000287310.2ASCL1, GRIA2, GAD1, GABRA4, NPY, BDNF
3MP:001077110.2JUN, BDNF, GABRA4, GRIA2, POLG, HCN2
4MP:000537810.2GAD1, GAP43, NPY, BDNF, JUN, DFFB
5MP:001076810.1DCX, GAD1, GAP43, BDNF, JUN, GRIA2
6MP:000538410.1JUN, BDNF, GAP43, GAD1, DFFB, GRIA2
7MP:000538610.1DCX, GAD1, GABRA4, NPY, CALB1, BDNF
8MP:000363110.0NHLRC1, JUN, BDNF, CALB1, NPY, GABRA4
9MP:000537610.0GAD1, NPY, BDNF, JUN, GRIA2, GRM2
10MP:000537710.0BDNF, CALB1, GRIA2, POLG, HCN2

Publications for Status Epilepticus

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Sources:
50PubMed
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Articles related to Status Epilepticus:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
The ketogenic diet for the treatment of pediatric status epilepticus. (24287234)
2014
2
Electrographic status epilepticus and long-term outcome in critically ill children. (24384638)
2014
3
Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. (23398413)
2013
4
Adjunctive enteral phenobarbital for adult status epilepticus: a brief report. (24379674)
2013
5
Monocyte chemoattractant protein-1 affects migration of hippocampal neural progenitors following status epilepticus in rats. (23339567)
2013
6
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus. (23663139)
2013
7
NMDA and AMPA receptors: development and status epilepticus. (24329701)
2013
8
Treatment of status epilepticus with ketamine, are we there yet? (23601960)
2013
9
Can status epilepticus sometimes just be a long seizure? (23840180)
2013
10
A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches. (24001067)
2013
11
Anesthetic drugs in status epilepticus: Risk or rescue?: A 6-year cohort study. (24319039)
2013
12
Usefulness of the bispectral index system density spectral array in monitoring non-convulsive status epilepticus. (23522763)
2013
13
Arg! Post-translational modifications in mitochondrial proteins after status epilepticus. (23840171)
2013
14
The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. (23163318)
2013
15
Quality assurance evaluation of a simple linear protocol for the treatment of impending status epilepticus in a pediatric emergency department 2 years postimplementation. (24064076)
2013
16
Cardiac injury in refractory status epilepticus. (23157562)
2013
17
Status epilepticus induces long lasting increase in S100A6 expression in astrocytes. (23817846)
2013
18
Lacosamide as a new treatment option in status epilepticus. (23293881)
2013
19
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. (23471864)
2013
20
Non-convulsive status epilepticus associated with glutamic acid decarboxylase antibody. (23820312)
2013
21
Status epilepticus in childhood. (22974358)
2013
22
Treatment of convulsive status epilepticus in childhood: recommendations of the Italian League Against Epilepsy. (24099053)
2013
23
Predictors of outcome in refractory status epilepticus. (23318514)
2013
24
Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). (22509732)
2012
25
Prediction of neuroprotective treatment efficiency using a HRMAS NMR-based statistical model of refractory status epilepticus on mouse: a metabolomic approach supported by histology. (22621346)
2012
26
EEG features of nonconvulsive status epilepticus. (23274165)
2012
27
Management of patients with status epilepticus treated at a pediatric intensive care unit in Turkey. (22633634)
2012
28
Complex partial non-convulsive status epilepticus masquerading as hepatic encephalopathy: a case report. (23244300)
2012
29
Hypertensive encephalopathy presenting as status epilepticus in a three year old. (21903352)
2012
30
Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation. (22732291)
2012
31
Ambulatory non-convulsive status epilepticus evolving into a malignant form. (22433253)
2012
32
Effect of mild hypothermia on glutamate receptor expression after status epilepticus. (22487868)
2012
33
A novel electrical stimulation paradigm for the suppression of epileptiform activity in an in vivo model of mesial temporal lobe status epilepticus. (23627622)
2012
34
Risk factors associated with death in in-hospital pediatric convulsive status epilepticus. (23110074)
2012
35
Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable. (22811762)
2012
36
Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. (22513140)
2012
37
Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate. (22215264)
2012
38
Differential diagnosis by EEG of dissociative status versus nonconvulsive status epilepticus. (22508074)
2012
39
Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. (22442695)
2012
40
A case of central cord syndrome related status epilepticus - a case report -. (22506176)
2011
41
Nonconvulsive status epilepticus in hepatic encephalopathy. (22224122)
2011
42
Non-convulsive status epilepticus and audiogenic seizures complicating a patient with asymmetrical epileptic spasms. (19735986)
2010
43
Status epilepticus revealing syphilitic meningoencephalitis. (21114135)
2010
44
Myoclonic status epilepticus in juvenile myoclonic epilepsy. (20045780)
2009
45
Status epilepticus in idiopathic generalized epilepsy. (16650150)
2006
46
Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus. (15246118)
2004
47
Transient Kluver-Bucy syndrome following complex partial status epilepticus. (12791340)
2003
48
Malnutrition increases hippocampal neurogenesis in the immature rat after status epilepticus]. (14761318)
2003
49
Non-convulsive status epilepticus: a treatable cause of confusion in pituitary apoplexy. (10889889)
2000
50
Theophylline-associated status epilepticus resulting in quadriplegia. (9087162)
1997

Genetic Variations for Status Epilepticus

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Expression for genes affiliated with Status Epilepticus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Status Epilepticus

Search GEO for disease gene expression data for Status Epilepticus.

Pathways for genes affiliated with Status Epilepticus

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Compounds for genes affiliated with Status Epilepticus

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Status Epilepticus according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1bicuculline44 2811.8GAD1, GABRA4
2baclofen44 1111.8CNR1, GAD1, NPY
3axokine4410.8BDNF, CNR1
4dnqx44 1111.8BDNF, GRIA2
5quisqualate44 1111.8BDNF, GRIA2, GRM2
6muscimol44 59 2812.8BDNF, NPY, GABRA4, GAD1
7nmda44 2811.8BDNF, GAP43, GAD1, GRM2, CNR1
8forskolin44 49 1112.7NPY, GAP43, GRM2, ENO2
9quinolinic acid44 2411.7GAD1, CALB1, BDNF
10catecholamine4410.7BDNF, NPY, GAP43, ENO2
11cocaine44 1111.7BDNF, NPY, GAP43, GRIA2, CNR1, SLC18A3
12taurine44 59 2412.7ENO2, GAD1, CALB1
13bromodeoxyuridine4410.7BDNF, CALB1, GAD1, DCX, ENO2
14carbachol44 28 1112.7BDNF, NPY, GAP43, CNR1
15valproate4410.7BDNF, GAD1, POLG
16glutamate4410.7CALB1, NPY, GAD1, GRIA2, GRM2, SLC18A3
17spec-t4410.7CNR1, SLC18A3, ENO2
18tetrodotoxin44 59 2812.7BDNF, CALB1, NPY, GAP43, GAD1, CNR1
19norepinephrine44 11 2412.7BDNF, CALB1, NPY, GAP43, CNR1, ENO2
20methamphetamine44 49 1112.7BDNF, CALB1, NPY
21adenylate4410.7BDNF, NPY, GAP43, POLG, CNR1, ENO2
225-hydroxytryptamine4410.7ENO2, CNR1, NPY, CALB1
23streptozotocin4410.7GAD1, NPY, BDNF
24aspartate4410.7BDNF, GAP43, GAD1, GRM2, CNR1, ENO2
25choline44 11 2412.6BDNF, CALB1, NPY, GAP43, GAD1, SLC18A3
26cyclic amp44 2411.6JUN, BDNF, NPY, GAP43, GRM2, HCN2
27potassium44 11 2412.6BDNF, CALB1, GAD1, HCN2, LGI1, ENO2
286-hydroxydopamine4410.6BDNF, NPY, GAP43
29arachidonic acid44 28 11 2413.6CPT1B, CNR1, GRIA2, GAP43, BDNF
30acetylcholine44 49 28 11 2414.6BDNF, CALB1, NPY, GAP43, GAD1, CNR1
31glutamine4410.6NPY, GAD1, GRIA2, POLG, ENO2
32ibotenic acid4410.6GAD1, NPY
33kainate44 2811.6CNR1, JUN, BDNF, CALB1, NPY, GAP43
34mptp4410.6GAD1, CALB1, BDNF
35gaba4410.6BDNF, CALB1, NPY, GABRA4, GAP43, GAD1
36acth4410.6BDNF, NPY, GAP43, ENO2
37aniracetam28 44 1112.6GRIA2, BDNF
38retinoic acid44 2411.6JUN, BDNF, CALB1, NPY, GAP43, SLC18A3
39atp44 2811.6BDNF, CALB1, NPY, GAP43, GAD1, DFFB
40glucose4410.5BDNF, CALB1, NPY, GAD1, CNR1, ENO2
41dopamine44 28 11 2413.5BDNF, CALB1, NPY, GAP43, GAD1, GRM2
42calcium44 49 11 2413.5BDNF, CALB1, NPY, GAP43, GAD1, DCX
43tyrosine4410.5JUN, BDNF, CALB1, NPY, GAP43, GAD1
44nitric oxide44 11 2412.4CALB1, NPY, GAP43, GAD1, SLC18A3, ENO2
45capsaicin44 2811.4CNR1, NPY, BDNF
46sodium44 2411.4BDNF, HCN2, SLC18A3, LGI1, ENO2
47vinblastine44 49 1112.4NPY, BDNF, JUN
48alanine4410.4NPY, GAP43, GAD1, POLG, CNR1, ENO2
49nbqx44 59 2812.3BDNF, GRIA2
50n-acetylaspartate4410.1BDNF, CALB1

GO Terms for genes affiliated with Status Epilepticus

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16Gene Ontology
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Cellular components related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.3LGI1, GRM2, GRIA2, GAP43, GABRA4

Biological processes related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:01404710.4GRM2, BDNF
2agingGO:00756810.3JUN, POLG, CNR1
3synaptic transmissionGO:00726810.2SLC18A3, HCN2, GRM2, GRIA2, GAD1, GABRA4
4central nervous system neuron developmentGO:02195410.1ASCL1, NPY

Molecular functions related to Status Epilepticus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel regulator activityGO:00524610.4GRM2, NPY
2glutamate receptor activityGO:00806610.1GRM2, GRIA2

Products for genes affiliated with Status Epilepticus

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  • Antibodies
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Sources for Status Epilepticus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet