MCID: STT001
MIFTS: 60

Status Epilepticus

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Status Epilepticus

MalaCards integrated aliases for Status Epilepticus:

Name: Status Epilepticus 12 49 28 51 41 14 69
Generalized Convulsive Status Epilepticus 49
Grand Mal Status Epilepticus 69
Gcse 49
Se 49

Classifications:



External Ids:

Disease Ontology 12 DOID:1824
MeSH 41 D013226
NCIt 46 C85079
ICD10 32 G41 C84.1 G41.0

Summaries for Status Epilepticus

MalaCards based summary : Status Epilepticus, also known as generalized convulsive status epilepticus, is related to febrile infection-related epilepsy syndrome and myoclonic astatic epilepsy, and has symptoms including symptomatic seizures and seizures. An important gene associated with Status Epilepticus is POLG (DNA Polymerase Gamma, Catalytic Subunit), and among its related pathways/superpathways are Circadian entrainment and MAPK signaling pathway. The drugs Ketamine and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 72 Status epilepticus (SE) is a single epileptic seizure lasting more than five minutes or two or more... more...

Related Diseases for Status Epilepticus

Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 febrile infection-related epilepsy syndrome 33.9 POLG SCN1A
2 myoclonic astatic epilepsy 32.4 GRIN2B SCN1A
3 brain injury 30.3 BDNF CASP3 ENO2 GFAP
4 neonatal hypoxic and ischemic brain injury 29.9 BDNF ENO2 PVALB
5 traumatic brain injury 29.8 BDNF CASP3 ENO2 GFAP
6 temporal lobe epilepsy 29.7 BDNF CALB1 GFAP GRIN2B NPY PVALB
7 west syndrome 29.4 GRIN2B NTRK2 PVALB SCN1A
8 bipolar disorder 29.0 BDNF GRIA1 GRIN2B NTRK2 POLG PVALB
9 schizophrenia 27.4 BDNF CALB1 CALB2 GAP43 GRIA1 GRIA2
10 norse 12.3
11 epileptic encephalopathy, early infantile, 6 11.6
12 epilepsy, pyridoxine-dependent 11.5
13 ring chromosome 20 11.4
14 mitochondrial dna depletion syndrome 4a 11.4
15 benign childhood occipital epilepsy, panayiotopoulos type 11.4
16 ceroid lipofuscinosis, neuronal, 10 11.2
17 benign familial neonatal epilepsy 11.2
18 salt and pepper developmental regression syndrome 11.1
19 epileptic encephalopathy, early infantile, 25 11.1
20 eastern equine encephalitis 11.1
21 chd2 myoclonic encephalopathy 11.1
22 epilepsy 10.5
23 breast fibrosarcoma 10.5 CALB1 PVALB
24 intracranial cysts 10.5 ENO2 GFAP
25 neuronitis 10.4
26 primitive neuroectodermal tumor of the cervix uteri 10.4 ENO2 GFAP
27 encephalopathy 10.4
28 melanotic medulloblastoma 10.4 ENO2 GFAP
29 encephalitis 10.3
30 ganglioneuroma 10.3 ENO2 GFAP NTRK2
31 pancreatic somatostatinoma 10.3 ENO2 SST
32 vertebral artery occlusion 10.3 BDNF NTRK2 SST
33 nodular ganglioneuroblastoma 10.3 BDNF ENO2 NTRK2
34 retroperitoneal neuroblastoma 10.3 ENO2 SST
35 spinal cord injury 10.3 BDNF CASP3 GFAP
36 nervous system cancer 10.3 CASP3 ENO2 GFAP
37 ganglioneuroblastoma 10.3 ENO2 NPY NTRK2
38 carcinoid syndrome 10.2 ENO2 NPY SST
39 fetal alcohol syndrome 10.2 GFAP GRIN2B PVALB
40 cerebritis 10.2
41 large cell carcinoma with rhabdoid phenotype 10.2 CALB2 ENO2
42 adjustment disorder 10.2 GAL NPY
43 neurosyphilis 10.2
44 motor neuron disease 10.2 BDNF CALB1 GRIA2 PVALB
45 neuronal ceroid-lipofuscinoses 10.2 CALB2 GFAP PVALB
46 peripheral nervous system neoplasm 10.1 BDNF CASP3 ENO2 NTRK2
47 autonomic nervous system neoplasm 10.1 BDNF CASP3 ENO2 NTRK2
48 fetal alcohol spectrum disorder 10.1 BDNF CASP3 GRIN2B
49 dysgerminoma of ovary 10.1 CALB2 ENO2 GFAP
50 duodenal somatostatinoma 10.1 ENO2 SST

Comorbidity relations with Status Epilepticus via Phenotypic Disease Network (PDN): (show all 17)


Acute Cystitis Alzheimer Disease
Bronchitis Cerebral Atherosclerosis
Decubitus Ulcer Deficiency Anemia
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to Status Epilepticus

Symptoms & Phenotypes for Status Epilepticus

UMLS symptoms related to Status Epilepticus:


symptomatic seizures, seizures

MGI Mouse Phenotypes related to Status Epilepticus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 GRIA2 NTRK2 GRIN2B JUN GRIA1 NPY
2 growth/size/body region MP:0005378 10.34 GRIA2 NTRK2 POLG GRIN2B GFAP JUN
3 cellular MP:0005384 10.23 GRIA2 NTRK2 POLG GFAP JUN PVALB
4 homeostasis/metabolism MP:0005376 10.18 NPY NTRK2 GRIA2 GRIN2B GFAP JUN
5 nervous system MP:0003631 10.16 NTRK2 POLG GRIN2B JUN GRIA1 NPY
6 mortality/aging MP:0010768 10.07 NTRK2 GRIA2 GRIN2B GFAP JUN POLG
7 integument MP:0010771 9.97 GRIA2 POLG JUN GRIA1 BDNF FOS
8 hearing/vestibular/ear MP:0005377 9.95 GRIA2 NTRK2 POLG BDNF FOS CALB1
9 no phenotypic analysis MP:0003012 9.65 GRIA2 POLG GRIN2B JUN GRIA1 PVALB
10 normal MP:0002873 9.47 GRIA2 NTRK2 GFAP JUN GRIA1 NPY

Drugs & Therapeutics for Status Epilepticus

Drugs for Status Epilepticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 3,Phase 2 6740-88-1 3821
2
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
3
Propofol Approved, Investigational, Vet_approved Phase 3,Phase 2 2078-54-8 4943
4
Thiopental Approved, Vet_approved Phase 3 76-75-5 3000715
5
Clobazam Approved, Illicit Phase 3 22316-47-8 2789
6
Clonazepam Approved, Illicit Phase 3 1622-61-3 2802
7
Lorazepam Approved Phase 3,Phase 2,Phase 1 846-49-1 3958
8
Valproic Acid Approved, Investigational Phase 3,Phase 2 99-66-1 3121
9 Piracetam Approved, Investigational Phase 3,Phase 2 7491-74-9
10
Phenytoin Approved, Vet_approved Phase 3 57-41-0 1775
11
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 3,Phase 2 439-14-5 3016
12
Paraldehyde Approved, Investigational Phase 3 123-63-7 31264
13
Fosphenytoin Approved, Investigational Phase 3 93390-81-9 56339
14
Topiramate Approved Phase 3 97240-79-4 5284627
15
Ethanol Approved Phase 3 64-17-5 702
16
Phenobarbital Approved, Investigational Phase 3,Phase 2 50-06-6 4763
17
Acetazolamide Approved, Vet_approved Phase 2, Phase 3 59-66-5 1986
18
Pentobarbital Approved, Investigational, Vet_approved Phase 3 76-74-4 4737
19
Sage Approved, Nutraceutical Phase 3,Phase 1,Phase 2
20
Glutamic Acid Approved, Nutraceutical Phase 2, Phase 3 56-86-0 33032
21 Strawberry Approved, Nutraceutical Phase 3
22 Etiracetam Investigational Phase 3,Phase 2 33996-58-6
23 Analgesics Phase 3,Phase 2
24 Anesthetics Phase 3,Phase 2
25 Anesthetics, Dissociative Phase 3,Phase 2
26 Anesthetics, General Phase 3,Phase 2
27 Anesthetics, Intravenous Phase 3,Phase 2
28 Anticonvulsants Phase 3,Phase 2,Phase 1
29 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
30 Excitatory Amino Acid Antagonists Phase 3,Phase 2
31 Excitatory Amino Acids Phase 3,Phase 2
32 GABA Agents Phase 3,Phase 2,Phase 1
33 GABA Modulators Phase 3,Phase 2,Phase 1
34 Hypnotics and Sedatives Phase 3,Phase 2,Phase 1
35 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
36 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
37 Anti-Anxiety Agents Phase 3,Phase 2,Phase 1
38 Antiemetics Phase 3,Phase 2,Phase 1
39 Autonomic Agents Phase 3,Phase 2,Phase 1
40 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
41 Psychotropic Drugs Phase 3,Phase 2,Phase 1
42 Tranquilizing Agents Phase 3,Phase 2,Phase 1
43 Antimanic Agents Phase 3,Phase 2
44 Neuroprotective Agents Phase 3,Phase 2
45 Nootropic Agents Phase 3,Phase 2
46 Protective Agents Phase 3,Phase 2
47 Diuretics, Potassium Sparing Phase 3
48 Sodium Channel Blockers Phase 3
49 Adjuvants, Anesthesia Phase 3,Phase 2
50 Neuromuscular Agents Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 75)

# Name Status NCT ID Phase Drugs
1 Ketamine in Refractory Convulsive Status Epilepticus Unknown status NCT02431663 Phase 3 Ketamine
2 Low Glycemic Index Diet Therapy in Children With Refractory Epilepsy Unknown status NCT01645072 Phase 3
3 Clobazam Use in Epilepsia Partialis Continua - Pilot Study Unknown status NCT02134366 Phase 3 Clobazam;Clonazepam;Lorazepam
4 Refractory Status Epilepticus Treatment Study Completed NCT01586208 Phase 3 valproic acid (VPA)
5 Lorazepam for the Treatment of Status Epilepticus or Repetitive Status Epilepticus in Japan Completed NCT02239380 Phase 3 Lorazepam
6 A Study With SAGE-547 for Super-Refractory Status Epilepticus Completed NCT02477618 Phase 3 SAGE-547;Placebo
7 Evaluation of Therapeutic Hypothermia in Convulsive Status EPILEPTICUS in Adults in Intensive Care Completed NCT01359332 Phase 3
8 Study of Antiepileptic Drug in Generalised Convulsive Status Epilepticus Completed NCT01150331 Phase 3 Levetiracetam/Clonazepam;Clonazepam/Placebo levetiracetam IV
9 Phase III Randomized Study of Diazepam Vs Lorazepam Vs Placebo for Prehospital Treatment of Status Epilepticus Completed NCT00004297 Phase 3 diazepam;lorazepam
10 Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications Completed NCT00809146 Phase 3 Intramuscular route of active treatment;Intravenous route of active treatment
11 Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2) Completed NCT00621478 Phase 2, Phase 3 lorazepam or diazepam
12 Nasal Versus Venous Lorazepam for Control of Acute Seizures in Children Completed NCT00735527 Phase 3 Lorazepam;Lorazepam
13 Intranasal Lorazepam Versus Intramuscular Paraldehyde in Paediatric Convulsions Completed NCT00116064 Phase 3 intranasal lorazepam;intramuscular paraldehyde
14 An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures. Completed NCT00991757 Phase 3 carisbamate
15 The Study of NPC-06 - Investigation of Safety, Efficacy and Pharmacokinetics of Fosphenytoin Completed NCT00908453 Phase 3 fosphenytoin
16 A Study of the Effectiveness and Safety of Topiramate Monotherapy in Patients With Recently Diagnosed Partial-Onset Seizure Completed NCT00230698 Phase 3 topiramate
17 Modified Atkins Diet in Childhood Epilepsy Completed NCT00836836 Phase 2, Phase 3
18 Established Status Epilepticus Treatment Trial Recruiting NCT01960075 Phase 3 Fosphenytoin;Levetiracetam;Valproic acid
19 Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus Recruiting NCT01870024 Phase 3 Clonazepam;Fosphenytoin;Placebo;Lorazepam
20 Open-label Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Children With Status Epilepticus (Convulsive) in a Healthcare Setting in Japan Recruiting NCT03336645 Phase 3 SHP615
21 Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus Recruiting NCT03115489 Phase 2, Phase 3 Traditional Treatment (Group T);Ketamine Infusion (Group K)
22 A Randomized Controlled Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6) Recruiting NCT02544763 Phase 3 GWP42003-P;Placebo
23 Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome Enrolling by invitation NCT02904265 Phase 2, Phase 3 Diazepam;Acetazolamide
24 An Open-label Extension Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6) Enrolling by invitation NCT02544750 Phase 3 GWP42003-P
25 Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Pediatric Patients With Status Epilepticus (Convulsive) in the Community Setting Not yet recruiting NCT03336450 Phase 3 SHP615;MHOS/SHP615
26 Treatment of Refractory Status Epilepticus Terminated NCT00265616 Phase 3 propofol;thiopental/pentobarbital
27 Randomized Trial Comparing 3 Routes of Delivering Lorazepam to Children. Terminated NCT00343096 Phase 3 Lorazepam
28 Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus Withdrawn NCT02726867 Phase 3 levetiracetam;lacosamide;Ketamine;Phenobarbital
29 Safety and Tolerability Study of Levetiracetam to Treat Patients With Status Epilepticus Unknown status NCT00362141 Phase 2 levetiracetam (add-on)
30 Study to Evaluate SAGE-547 Injection as Adjunctive Therapy for the Treatment of Super-Refractory Status Epilepticus Completed NCT02052739 Phase 1, Phase 2 SAGE-547
31 Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus Completed NCT02920060 Phase 2 Intravenous levetiracetam;Sodium valproate
32 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
33 Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus Recruiting NCT03025906 Phase 2 Phenobarbital;Valproate
34 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2 Cannabidiol
35 Intravenous Ganaxolone as Adjunctive Therapy to Treat Subjects With Status Epilepticus Not yet recruiting NCT03350035 Phase 2 Ganaxolone;Placebo
36 Intravenous Levetiracetam as First-line Anticonvulsive Treatment in Patients With Non-convulsive Status Epilepticus Withdrawn NCT00603135 Phase 2 first-line i/v-levetiracetam
37 Lorazepam for the Treatment of Status Epilepticus in Children Completed NCT00114569 Phase 1 lorazepam
38 Safety and Efficacy of Intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures Unknown status NCT01268904 Valproate
39 EEG in In-hospital Patients With Seizure or Altered Mental State Unknown status NCT02383745
40 EEG in Resuscitated In-hospital Patients Unknown status NCT02349087
41 Assessment of Severity and Prognosis for Patients With Status Epileptics(SE) Unknown status NCT02269137
42 Comparing Simplified EEG Monitoring Tool With Standard EEG Monitoring in Patients With Acute Neurological Insult Unknown status NCT02545816
43 Electrical Status Epilepticus in Sleep: Response of Neuropsychological Deficits and Epileptiform Activity to Clobazam Treatment Completed NCT02127918 ESES treated with clobazam
44 Prognosis Factors Associated With Convulsive Status Epilepticus in Adults Completed NCT00318578
45 Ketogenic Diet for Refractory Status Epilepticus Completed NCT01796574
46 Putting Electroencephalography (EEG) in the Emergency Department Completed NCT01355211
47 Smartphone Apps for Pediatric Resuscitation Completed NCT02958605
48 The Rolandic Epilepsy/ESES/Landau-Kleffner Syndrome and Correlation With Language Impairment Study Completed NCT01335425
49 Neuromonitoring of Hepatic Encephalopathy Completed NCT01878305
50 Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment Completed NCT02381977

Search NIH Clinical Center for Status Epilepticus

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: status epilepticus

Genetic Tests for Status Epilepticus

Genetic tests related to Status Epilepticus:

# Genetic test Affiliating Genes
1 Status Epilepticus 28

Anatomical Context for Status Epilepticus

MalaCards organs/tissues related to Status Epilepticus:

38
Brain, Temporal Lobe, Cortex, Liver, Amygdala, Heart, Bone Marrow

Publications for Status Epilepticus

Articles related to Status Epilepticus:

(show top 50) (show all 915)
# Title Authors Year
1
Systemic Complications Following Status Epilepticus. ( 29417304 )
2018
2
Progression of Convulsive and Nonconvulsive Seizures During Epileptogenesis After Pilocarpine-Induced Status Epilepticus. ( 29442558 )
2018
3
Can endotracheal intubation be the first step in management of nonconvulsive status epilepticus?: A case report. ( 29443785 )
2018
4
Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. ( 29399791 )
2018
5
Febrile infection-related epilepsy syndrome (FIRES) with super-refractory status epilepticus revealing autoimmune encephalitis due to GABA<sub>A</sub>R antibodies. ( 29203057 )
2018
6
Efficacy of lacosamide in children and adolescents with drug-resistant epilepsy and refractory status epilepticus: A systematic review. ( 29428899 )
2018
7
Disseminated cysticercosis presenting as status epilepticus, rhabdomyolysis, and acute kidney injury: An unreported complication. ( 29322996 )
2018
8
The effect of vagus nerve stimulator in controlling status epilepticus in children. ( 29414137 )
2018
9
Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models. ( 29410648 )
2018
10
The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus. ( 29438777 )
2018
11
Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus. ( 29414381 )
2018
12
Successful Use of Ketamine for Burst Suppression in Super Refractory Status Epilepticus Following Substance Abuse. ( 29422735 )
2018
13
Successful Phenobarbital Desensitization After DRESS Reaction in the Management of Refractory Status Epilepticus. ( 29390946 )
2018
14
Avoiding errors when administering injectable phenytoin to a child in status epilepticus. ( 29412538 )
2018
15
Convulsive status epilepticus in a quaternary hospital paediatric intensive care unit (PICU) in South Africa: An 8 year review. ( 28886496 )
2017
16
Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline. ( 28084627 )
2017
17
Evolution of Cerebral Atrophy in a Patient with Super Refractory Status Epilepticus Treated with Barbiturate Coma. ( 28182114 )
2017
18
Emergency Neurological Life Support: Status Epilepticus. ( 28913605 )
2017
19
Super-refractory Status Epilepticus with Hemophagocytic Syndrome in a Child with HIV Infection. ( 28088756 )
2017
20
Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study. ( 28919386 )
2017
21
Successful surgical management of New Onset Refractory Status Epilepticus (NORSE) presenting with gelastic seizures in a 3A year old girl. ( 28725554 )
2017
22
Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice. ( 28079889 )
2017
23
Status epilepticus: An overview. ( 28059037 )
2017
24
A 6-Month-Old Girl with Incontinentia Pigmenti Presenting as Status Epilepticus. ( 29344471 )
2017
25
Plasma Exchange as a Therapeutic Modality in a Rare Case of Cryptogenic New Onset Refractory Status Epilepticus (NORSE). ( 28892919 )
2017
26
Emergency Surgery for Refractory Status Epilepticus. ( 28891483 )
2017
27
Dentate gyrus autonomous ictal activity in the status epilepticus rat model of epilepsy. ( 28062187 )
2017
28
A Case of Status-Epilepticus-Associated Transient Hyperammonemia in the Emergency Department. ( 29435374 )
2017
29
A case of rhabdomyolysis after status epilepticus without stroke-like episodes in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. ( 28637934 )
2017
30
Hemispherotomy for late post-traumatic super-refractory status epilepticus in an adult. ( 29379714 )
2017
31
The Clinical Characteristics and Prognostic Analysis of Status Epilepticus in Northeast China. ( 28942441 )
2017
32
Systemic inflammatory response syndrome in the course of status epilepticus: 7-year, two-center observational study. ( 28938136 )
2017
33
Effect of diet with omega-3 in basal brain electrical activity and during status epilepticus in rats. ( 28892741 )
2017
34
New-Onset Status Epilepticus in Pediatric Patients: Causes, Characteristics, and Outcomes. ( 29373157 )
2017
35
Gyriform Infarction in Cerebral Air Embolism: Imaging Mimicker of Status Epilepticus. ( 28904468 )
2017
36
Diagnosis of Electrical Status Epilepticus During Slow-Wave Sleep With 100 Seconds of Sleep. ( 28045858 )
2017
37
Neuroprotective effect of lithium after pilocarpine-induced status epilepticus in mice. ( 28066149 )
2017
38
Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus. ( 28088683 )
2017
39
Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus. ( 28870089 )
2017
40
Abnormal neurovascular coupling during status epilepticus migrainosus in Sturge-Weber syndrome. ( 27903813 )
2017
41
Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms. ( 28061403 )
2017
42
The role of necroptosis in status epilepticus-induced brain injury in juvenile rats. ( 28863321 )
2017
43
New onset refractory status epilepticus due to primary angiitis of the central nervous system. ( 29062691 )
2017
44
Electrical status epilepticus during sleep in Mowat-Wilson syndrome. ( 28501473 )
2017
45
p47Phox/CDK5/DRP1-Mediated Mitochondrial Fission Evokes PV Cell Degeneration in the Rat Dentate Gyrus Following Status Epilepticus. ( 28919853 )
2017
46
Fatal Cerebral Edema With Status Epilepticus in Children With Dravet Syndrome: Report of 5 Cases. ( 28330972 )
2017
47
Epilepsy is associated with ventricular alterations following convulsive status epilepticus in children. ( 29430560 )
2017
48
Electroconvulsive Therapy for Super Refractory Status Epilepticus. ( 28937549 )
2017
49
miR-96 attenuates status epilepticus-induced brain injury by directly targeting Atg7 and Atg16L1. ( 28860495 )
2017
50
The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats. ( 29375315 )
2017

Variations for Status Epilepticus

Expression for Status Epilepticus

Search GEO for disease gene expression data for Status Epilepticus.

Pathways for Status Epilepticus

Pathways related to Status Epilepticus according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 FOS GRIA1 GRIA2 GRIN2B SCN1A
2 12.62 BDNF CASP3 FOS JUN NTRK2
3
Show member pathways
12.58 BDNF CASP3 FOS JUN NTRK2
4
Show member pathways
12.46 BDNF FOS GRIA1 GRIA2 GRIN2B NTRK2
5
Show member pathways
12.33 CASP3 GABRA4 JUN NTRK2
6 12.04 BDNF CASP3 JUN NTRK2 SST
7
Show member pathways
12.03 BDNF FOS JUN NTRK2
8
Show member pathways
12 BDNF FOS GRIA1 GRIA2 GRIN2B JUN
9 11.88 BDNF CASP3 FOS GAP43 GFAP
10 11.85 CALB1 ENO2 GAP43 GFAP GRIA1 GRIA2
11
Show member pathways
11.84 CASP3 GRIA1 GRIA2 GRIN2B
12
Show member pathways
11.8 BDNF FOS GRIA1 GRIA2 GRIN2B JUN
13
Show member pathways
11.73 GRIA1 GRIA2 GRIN2B
14 11.72 BDNF CASP3 FOS GRIA1 GRIA2 GRIN2B
15
Show member pathways
11.64 CASP3 FOS JUN
16 11.63 CASP3 FOS JUN
17 11.53 CASP3 FOS JUN
18 11.49 BDNF GRIA1 SST
19 11.32 CALB1 FOS JUN
20 11.27 GABRA4 GRIA1 GRIA2 GRIN2B
21 10.91 BDNF FOS GFAP JUN NTRK2
22 10.78 BDNF CASP3 NTRK2
23 10.67 FOS JUN

GO Terms for Status Epilepticus

Cellular components related to Status Epilepticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.72 CALB1 CALB2 FOS GRIA1 GRIN2B
2 postsynaptic density GO:0014069 9.71 GAP43 GRIA1 GRIN2B NTRK2
3 synapse GO:0045202 9.7 CALB1 CALB2 GABRA4 GAP43 GRIA1 GRIA2
4 postsynaptic membrane GO:0045211 9.65 GABRA4 GRIA1 GRIA2 GRIN2B NTRK2
5 neuronal cell body GO:0043025 9.5 CALB1 ENO2 GAL GRIA1 PVALB SCN1A
6 transcription factor AP-1 complex GO:0035976 9.37 FOS JUN
7 terminal bouton GO:0043195 9.02 CALB1 CALB2 NTRK2 POLG PVALB

Biological processes related to Status Epilepticus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.92 BDNF FOS GAL GAP43 NTRK2
2 ion transmembrane transport GO:0034220 9.81 GABRA4 GRIA1 GRIA2 SCN1A
3 response to drug GO:0042493 9.72 CASP3 FOS GAL JUN SST
4 excitatory postsynaptic potential GO:0060079 9.63 GRIA1 GRIA2 GRIN2B
5 response to wounding GO:0009611 9.61 CASP3 GAP43 GFAP
6 learning or memory GO:0007611 9.58 CALB1 CASP3 GRIN2B
7 feeding behavior GO:0007631 9.54 GAL NPY NTRK2
8 axon development GO:0061564 9.49 GAP43 GFAP
9 central nervous system neuron development GO:0021954 9.48 NPY NTRK2
10 chemical synaptic transmission GO:0007268 9.35 GRIA1 GRIA2 GRIN2B NPY SST
11 regulation of cytosolic calcium ion concentration GO:0051480 9.33 CALB1 CALB2 PVALB
12 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 9.26 BDNF NTRK2
13 ionotropic glutamate receptor signaling pathway GO:0035235 8.8 GRIA1 GRIA2 GRIN2B

Molecular functions related to Status Epilepticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellularly glutamate-gated ion channel activity GO:0005234 9.33 GRIA1 GRIA2 GRIN2B
2 excitatory extracellular ligand-gated ion channel activity GO:0005231 9.32 GRIA1 GRIA2
3 AMPA glutamate receptor activity GO:0004971 9.26 GRIA1 GRIA2
4 ionotropic glutamate receptor activity GO:0004970 9.13 GRIA1 GRIA2 GRIN2B
5 ion channel activity GO:0005216 9.02 GABRA4 GRIA1 GRIA2 GRIN2B SCN1A

Sources for Status Epilepticus

3 CDC
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