MCID: STT004
MIFTS: 40

Steatorrhea malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Steatorrhea

Aliases & Descriptions for Steatorrhea:

Name: Steatorrhea 12 29 52 42 14
Fatty Stool 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10602
MeSH 42 D045602
NCIt 47 C86917
UMLS 69 C0038238

Summaries for Steatorrhea

MalaCards based summary : Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and celiac disease. An important gene associated with Steatorrhea is PNLIP (Pancreatic Lipase), and among its related pathways/superpathways are Lipoprotein metabolism and Statin Pathway. The drugs Pancrelipase and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and colon, and related phenotype is homeostasis/metabolism.

Wikipedia : 71 Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may be bulky and difficult... more...

Related Diseases for Steatorrhea

Diseases related to Steatorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 pancreatic steatorrhea 12.1
2 celiac disease 11.2
3 tropical sprue 11.1
4 blind loop syndrome 11.1
5 glucose intolerance 11.1
6 bile acid malabsorption, primary 10.9
7 hypobetalipoproteinemia 10.8
8 hypomagnesemia 1, intestinal 10.8
9 pancreatitis 10.4
10 abducens nerve neoplasm 10.2 APOC2 PNLIP
11 gastrointestinal neuroendocrine benign tumor 10.2 CCK SCT
12 tricuspid valve insufficiency 10.2 CCK SCT
13 bazex syndrome 10.2 CCK SCT
14 breast malignant eccrine spiradenoma 10.2 CCK SCT
15 adult brain stem glioma 10.2 CCK SCT
16 primrose syndrome 10.2 CCK SCT
17 gmppa-cdg 10.2 SCT SST
18 tooth erosion 10.2 SCT SST
19 myxofibrosarcoma 10.2 CFTR SCT
20 peripheral degeneration of cornea 10.2 SCT SST
21 progressive relapsing multiple sclerosis 10.2 SCT SST
22 tabes dorsalis 10.1 SCT SST
23 myocardial stunning 10.1 CCK SST
24 acute pyelonephritis 10.1 SCT SST
25 maturity-onset diabetes of the young, type 13 10.1 SCT SST
26 eccrine papillary adenocarcinoma 10.1 SCT SST
27 scleral staphyloma 10.1 CCK SST
28 inflammatory diarrhea 10.1 CFTR SST
29 cervical adenomyoma 10.1 CCK CFTR
30 fibrosis of extraocular muscles, congenital, 3c 10.1 CFTR PNLIP SCT
31 rickets 10.1 CCK SST
32 red cell phospholipid defect with hemolysis 10.0 CCK SST
33 tricuspid valve stenosis 10.0 CCK SCT SST
34 gemistocytic astrocytoma 10.0 CCK SCT SST
35 retinal vascular occlusion 10.0 CCK SCT SST
36 mandibular cancer 10.0 CCK SST
37 childhood malignant hemangiopericytoma 10.0 CCK SCT SST
38 diarrhea 10.0
39 hypoparathyroidism 10.0
40 neurological consequences of cytomegalovirus infection 10.0 CCK SST
41 childhood intracortical osteosarcoma 10.0 CCK SST
42 acute gonococcal cervicitis 10.0 CCK CELA1 PNLIP SCT
43 cystic fibrosis 10.0
44 mitochondrial complex iii deficiency, nuclear type 4 10.0 MTTP SLC10A2
45 borderline leprosy 10.0 CCK SST
46 female stress incontinence 9.9 CCK CFTR PNLIP SCT
47 netherton syndrome 9.9 CCK CFTR PNLIP SCT
48 gastrointestinal adenoma 9.9 CCK SLC10A2
49 duodenitis 9.9
50 chondroma 9.9 CCK CELA1 SCT SST

Graphical network of the top 20 diseases related to Steatorrhea:



Diseases related to Steatorrhea

Symptoms & Phenotypes for Steatorrhea

MGI Mouse Phenotypes related to Steatorrhea:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 APOC2 CCK CFTR MTTP PNLIP SLC10A2

Drugs & Therapeutics for Steatorrhea

Drugs for Steatorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1 53608-75-6
2 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
3 pancreatin Phase 4,Phase 3,Phase 2,Phase 1
4
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
5 Antacids Phase 3
6 Anti-Ulcer Agents Phase 3
7
Proton pump inhibitors Phase 3
8 Pharmaceutical Solutions Phase 2, Phase 3
9
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
10
Phytonadione Approved, Nutraceutical Phase 1 84-80-0 4812 5284607
11 Antifibrinolytic Agents Phase 1
12 Coagulants Phase 1
13 Hemostatics Phase 1
14 Micronutrients Phase 1
15 Trace Elements Phase 1
16 Vitamins Phase 1
17 Menaquinone Nutraceutical Phase 1
18 naphthoquinone Nutraceutical Phase 1
19 Vitamin K Nutraceutical Phase 1
20
Nicotine Approved 54-11-5 942 89594
21
Teriparatide Approved, Investigational 52232-67-4 16133850
22 Antibodies
23 Immunoglobulins
24 Bone Density Conservation Agents
25 Calcium, Dietary
26 glucocorticoids
27 vitamin d
28 Bile Acids and Salts
29 Cholic Acids

Interventional clinical trials:

(show all 27)
id Name Status NCT ID Phase
1 Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT01327703 Phase 4
2 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
3 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4
4 Pancreatic Enzyme Suppletion in Pancreatic Cancer Withdrawn NCT01401387 Phase 4
5 Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea Completed NCT00559364 Phase 3
6 Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) Completed NCT00880100 Phase 3
7 Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis Completed NCT00432861 Phase 3
8 Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) Completed NCT00408317 Phase 3
9 A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency Completed NCT00662675 Phase 3
10 Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) Completed NCT00513682 Phase 3
11 Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation Active, not recruiting NCT01967888 Phase 2, Phase 3
12 Creon in HIV Patients With Steatorrhea Terminated NCT00623025 Phase 3
13 Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs Withdrawn NCT01228643 Phase 3
14 An Effectiveness, Safety, and Palatability Study of Pancrelipase Microtablets in Infants and Toddlers With Cystic Fibrosis and Fat Malabsorption Completed NCT00217204 Phase 2
15 Tolerance and Digestibility of a New Formula in Healthy Infants Completed NCT01184378 Phase 2
16 An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI) Completed NCT00559052 Phase 2
17 A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI) Completed NCT00676702 Phase 1
18 Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic Fibrosis Completed NCT00006063
19 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
20 Horton & Maizy Pilot Study for Resistant to Starch Completed NCT01338571
21 Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis Completed NCT01527084
22 Celiac Disease Diagnosis in Patients With Weakly Positive Serum Anti-Transglutaminase: Duodenal Anti-Endomysium Assay. Recruiting NCT02242123
23 Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders Recruiting NCT02252679
24 Effect of Potato Fiber on Appetite and Fecal Fat Excretion Active, not recruiting NCT02957318
25 Comparison of Feasibility Between Internal and External Pancreatic Drainage in Pancreaticoduodenectomy Active, not recruiting NCT01023594
26 The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms" Active, not recruiting NCT02121626
27 The Replace Registry Not yet recruiting NCT03115086

Search NIH Clinical Center for Steatorrhea

Cochrane evidence based reviews: steatorrhea

Genetic Tests for Steatorrhea

Genetic tests related to Steatorrhea:

id Genetic test Affiliating Genes
1 Steatorrhea 29

Anatomical Context for Steatorrhea

MalaCards organs/tissues related to Steatorrhea:

39
Testes, Bone, Colon, Pancreas, Liver, Small Intestine, Pituitary

Publications for Steatorrhea

Articles related to Steatorrhea:

(show top 50) (show all 314)
id Title Authors Year
1
Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass. ( 28089681 )
2017
2
Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients. ( 26877248 )
2016
3
Dietary green-plant thylakoids decrease gastric emptying and gut transit, promote changes in the gut microbial flora, but does not cause steatorrhea. ( 27777602 )
2016
4
50 years ago in the journal of pediatrics: disaccharidase deficiencies with steatorrhea. ( 24359902 )
2014
5
Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate. ( 23499748 )
2013
6
Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection. ( 23395568 )
2013
7
Pancreatic lipomatosis with massive steatorrhea. ( 22081194 )
2011
8
Education and imaging. Gastrointestinal: "floating oil droplets in the colonic fluid": colonoscopic findings in a patient with pancreatic exocrine insufficiency and steatorrhea. ( 21564288 )
2011
9
Chronic pancreatitis and persistent steatorrhea: what is the correct dose of enzymes? ( 21377551 )
2011
10
Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea. ( 20146370 )
2010
11
Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. ( 19238028 )
2009
12
Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. ( 19034041 )
2009
13
Spontaneous exocrine pancreas hypoplasia in specific pathogen-free C3HeB/FeJ and 101/H mouse pups causes steatorrhea and runting. ( 17536623 )
2007
14
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. ( 16954337 )
2007
15
The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis. ( 16868481 )
2006
16
Unresponsive or non-compliant steatorrhea in cystic fibrosis? ( 16765107 )
2006
17
An enteric-coated high-buffered pancrelipase reduces steatorrhea in patients with cystic fibrosis: a prospective, randomized study. ( 16863712 )
2006
18
Does pancreatic elastase-1 in stools predict steatorrhea in type 1 diabetes? ( 16505538 )
2006
19
The incidence, pathogenesis and natural history of steatorrhea after bone marrow transplantation. ( 12728924 )
2003
20
High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. ( 14560984 )
2003
21
Rethinking growth failure in Alagille syndrome: the role of dietary intake and steatorrhea. ( 12394373 )
2002
22
Association between steatorrhea, growth, and immunologic status in children with perinatally acquired HIV infection. ( 11177089 )
2001
23
Are minimicrosphere pancrelipase capsules effective enough for the treatment of pancreatic steatorrhea? ( 11374718 )
2001
24
Massive steatorrhea in a child due to isolated pancreatic hypoplasia. ( 11721073 )
2001
25
Positive results on tests for steatorrhea in persons consuming olestra potato chips. ( 10681282 )
2000
26
A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. ( 10950038 )
2000
27
Fecal weight determination can unfortunately not replace unpopular and costly fecal fat estimation in the diagnosis of steatorrhea. ( 10211425 )
1999
28
Study on pancreatic insufficiency (chronic pancreatitis) and steatorrhea in Japanese patients with low fat intake. ( 10026440 )
1999
29
Prevalence and significance of steatorrhea in patients with active Graves' disease. ( 9672342 )
1998
30
Steatorrhea and weight loss in a 72-year-old man: primary biliary cirrhosis? Celiac disease? Bacterial overgrowth? What else? ( 9820402 )
1998
31
Steatorrhea cannot be excluded where there is a fecal weight below 0.200 kg per day and a high fecal consistency. ( 9890341 )
1998
32
Esophageal impairment in adult celiac disease with steatorrhea. ( 9707045 )
1998
33
Determination of fecal fat concentration by near infrared spectrometry for the screening of pancreatic steatorrhea. ( 9520087 )
1998
34
Can pancreatic steatorrhea be diagnosed without chemical analysis? ( 9387033 )
1997
35
Acid steatocrit: a simple, rapid gravimetric method to determine steatorrhea. ( 9399770 )
1997
36
Pancreatic steatorrhea, malabsorption, and nutrition biochemistry: a comparison of Japanese, European, and American patients with chronic pancreatitis. ( 9163777 )
1997
37
Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea? ( 9178698 )
1997
38
Bone mineral density in patients with pancreatic insufficiency and steatorrhea. ( 9149203 )
1997
39
Steatorrhea: a common manifestation in patients with HIV/AIDS. ( 8878143 )
1996
40
Evaluation of steatorrhea during acute infectious enteritis. ( 8890096 )
1996
41
Intestinal lymphangiectasia in a patient with autoimmune polyglandular disease type I and steatorrhea. ( 7883852 )
1995
42
Steatorrhea in Japanese patients with chronic pancreatitis. ( 7719419 )
1995
43
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. ( 8113582 )
1994
44
Steatocrit: a reliable semiquantitative method for detection of steatorrhea. ( 7806830 )
1994
45
Fat-soluble vitamin concentration in chronic alcohol-induced pancreatitis. Relationship with steatorrhea. ( 8174441 )
1994
46
Octreotide decreases biliary and pancreatic exocrine function, and induces steatorrhea in healthy subjects. ( 7827373 )
1994
47
Can diarrhea cause secondary steatorrhea? ( 1587441 )
1992
48
Fecal alpha 1-antitrypsin clearance in the differential diagnosis of steatorrhea. ( 1300854 )
1992
49
Effectiveness of enteric coated pancreatic enzymes given before meals in reducing steatorrhea in children with cystic fibrosis. ( 1624649 )
1992
50
Treatment of severe steatorrhea with ox bile in an ileectomy patient with residual colon. ( 1587199 )
1992

Variations for Steatorrhea

Expression for Steatorrhea

Search GEO for disease gene expression data for Steatorrhea.

Pathways for Steatorrhea

GO Terms for Steatorrhea

Cellular components related to Steatorrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 APOC2 CCK CELA1 SCT SST
2 extracellular region GO:0005576 9.1 APOC2 CCK CELA1 PNLIP SCT SST

Biological processes related to Steatorrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.32 APOC2 MTTP
2 retinoid metabolic process GO:0001523 9.26 APOC2 PNLIP
3 lipoprotein metabolic process GO:0042157 9.16 APOC2 MTTP
4 lipoprotein transport GO:0042953 8.96 APOC2 MTTP
5 chylomicron assembly GO:0034378 8.62 APOC2 MTTP

Molecular functions related to Steatorrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CCK SCT SST

Sources for Steatorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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