MCID: STT004
MIFTS: 50

Steatorrhea malady

Summaries for Steatorrhea

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63Wikipedia, 32MalaCards
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Wikipedia:63 Steatorrhea (or steatorrhoea) is the presence of excess fat in faeces. Stools may also float due to... more...

MalaCards: Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and pancreatitis. An important gene associated with Steatorrhea is CELA1 (chymotrypsin-like elastase family, member 1), and among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Digestion of dietary lipid. The compounds cerulein and loxiglumide have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and bone, and related mouse phenotypes are digestive/alimentary and growth/size.

Aliases & Classifications for Steatorrhea

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

steatorrhea 8 10 44 60
fatty stool 8


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Disease Ontology8 DOID:10602
NCIt39 C86917
SNOMED-CT56 66187002
MeSH34 D045602

Related Diseases for Steatorrhea

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17GeneCards, 18GeneDecks
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Diseases related to Steatorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic steatorrhea31.0PRSS1, PNLIP, CELA3B, CELA1
2pancreatitis30.9ELANE, CELA1, CELA3B, TMPRSS15, PNLIP, CFTR
3diarrhea30.4GCG, MLN, SST, CFTR
4cystic fibrosis30.3SCT, LPL, PRSS1, CFTR, PNLIP, CELA3B
5celiac disease30.3CCK
6exocrine pancreatic insufficiency30.2ELANE, CELA1, CELA3B, PNLIP, CFTR, SCT
7diabetes mellitus30.2GCG, CCK, APOC2, SCT, LPL, MLN
8zollinger-ellison syndrome30.1SCT, SST
9intestinal obstruction29.9CFTR
10intestinal pseudo-obstruction29.7SST
11cholestasis29.6SLC10A2, CCK, GCG
12abetalipoproteinemia29.6MTTP, LPL
13duodenal ulcer29.6CCK, SCT, SST
14intrahepatic cholestasis29.6SLC10A2, SCT
15adenoma29.6SST, SCT, GCG
16irritable bowel syndrome29.6MLN, CCK
17alcoholic pancreatitis29.6CCK, SCT, CFTR, ELANE
18adenocarcinoma29.6CCK, SCT, PRSS1, SST, PNLIP
19pancreas disease29.6CLPS, CFTR, PNLIP, TMPRSS15, ELANE, SCT
20obesity29.6GCG, CCK, LPL, MLN, MTTP, CLPS
21acute pancreatitis29.6CCK, APOC2, SCT, LPL, SST, CLPS
22hypoparathyroidism10.3
23duodenitis10.2
24tropical sprue10.1
25intestinal disease10.0
26systemic scleroderma10.0
27hyperparathyroidism10.0SCT
28cholesterol ester storage disease10.0PNLIP
29glossitis10.0GCG
30cholangitis10.0CFTR
31polycystic ovary syndrome10.0GCG
32angiodysplasia10.0SST
33cholangiocarcinoma10.0PNLIP, SCT
34somatostatinoma10.0SST
35lipoprotein lipase deficiency10.0LPL
36familial lipoprotein lipase deficiency10.0LPL
37acromegaly10.0SST, CCK
38neuroendocrine tumor10.0GCG, SST
39hyperinsulinemic hypoglycemia10.0SCT, SST
40anorexia nervosa10.0GCG, CCK
41endocrine gland cancer10.0GCG, SST
42hereditary pancreatitis10.0PRSS1, CFTR
43cholelithiasis10.0SST, CCK
44vipoma10.0SST, SCT
45gastrinoma10.0GCG, SCT, SST
46ileus10.0MLN
47peptic ulcer10.0CCK, SCT, SST
48familial hypertriglyceridemia10.0LPL, SLC10A2
49short bowel syndrome10.0GCG, CCK, SST
50cushing's syndrome10.0SST

Graphical network of the top 20 diseases related to Steatorrhea:



Diseases related to steatorrhea

Clinical Features for Steatorrhea

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Drugs & Therapeutics for Steatorrhea

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Steatorrhea

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Anatomical Context for Steatorrhea

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32MalaCards
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MalaCards organs/tissues related to Steatorrhea:

32
Testes, Pancreas, Bone, Colon, Small intestine, Liver, Bone marrow, Pituitary, Thyroid, Pancreatic islet

Animal Models for Steatorrhea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Steatorrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.1GCG, SST, CLPS, CFTR, PNLIP, SLC10A2
2MP:00053787.4GCG, LPL, MTTP, SST, CLPS, CFTR
3MP:00053766.4ELANE, COX4I2, GCG, CCK, SCT, LPL

Publications for Steatorrhea

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50PubMed
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Articles related to Steatorrhea:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. (19034041)
2009
2
A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. (10950038)
2000
3
Positive results on tests for steatorrhea in persons consuming olestra potato chips. (10681282)
2000
4
Study on pancreatic insufficiency (chronic pancreatitis) and steatorrhea in Japanese patients with low fat intake. (10026440)
1999
5
Steatorrhea and weight loss in a 72-year-old man: primary biliary cirrhosis? Celiac disease? Bacterial overgrowth? What else? (9820402)
1998
6
Determination of fecal fat concentration by near infrared spectrometry for the screening of pancreatic steatorrhea. (9520087)
1998
7
Bone mineral density in patients with pancreatic insufficiency and steatorrhea. (9149203)
1997
8
Acid steatocrit: a simple, rapid gravimetric method to determine steatorrhea. (9399770)
1997
9
Intestinal lymphangiectasia in a patient with autoimmune polyglandular disease type I and steatorrhea. (7883852)
1995
10
Effectiveness and safety of small vs. large doses of enteric coated pancreatic enzymes in reducing steatorrhea in children with cystic fibrosis: a prospective randomized study. (2030925)
1991
11
Dietary therapy of steatorrhea. (2509353)
1989
12
Steatorrhea and disorders of chylomicron synthesis and secretion. (3277133)
1988
13
Serum cathodic trypsin-like immunoreactivity, pancreatic lipase, and pancreatic isoamylase as diagnostic tests of chronic pancreatitis or pancreatic steatorrhea. (3291084)
1988
14
Hypercortisolism, diarrhea with steatorrhea, and massive proteinuria due to pheochromocytoma. (2861663)
1985
15
Increased risk of nephrolithiasis in patients with steatorrhea. (7075427)
1982
16
Estimation of fat absorption from single fecal specimens using 131I-triolein and 75Se-triether. A study in rats with and without induced steatorrhea. (832788)
1977
17
Idiopathic hypoparathyroidism and steatorrhea: a new aid in management. (4443861)
1974
18
Acute quadriparesis with mucle spasms related to electrolyte disturbances in steatorrhea. Clinical and biochemical data. (5030181)
1972
19
Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. (5029077)
1972
20
Fecal hydroxy fatty acids excretion in steatorrhea. (5016378)
1972
21
Lymphomas of small bowel and their relationship to idiopathic steatorrhea. (4887681)
1969
22
Malignancy and steatorrhea. (4887368)
1968
23
The Zollinger-Ellison syndrome with steatorrhea. II. The mechanism of fat and vitamin B 12 malabsorption. (5715664)
1968
24
Hydroxy acid excretion in steatorrhea of pancreatic and nonpancreatic origin. (5722917)
1968
25
Idiopathic tropical diarrhea with or without steatorrhea (tropical malabsorption syndrome). (5945813)
1966
26
Pancreatic exocrine insufficiency and proteolytic enzymes in stool. A critical evaluation of a new diagnostic test in various forms of steatorrhea. (5972656)
1966
27
Steatorrhea complicating diabetes mellitus. (5837763)
1965
28
MASSIVE GASTROINTESTINAL HEMORRHAGE-A COMPLICATION OF IDIOPATHIC STEATORRHEA. (14144543)
1964
29
STEATORRHEA; A CLINICAL-PATHOLOGIC CORRELATION. (14077936)
1963
30
Steatorrhea in diabetic patients. (13990248)
1962
31
Differences in absorption of the various fatty acids studied in children with steatorrhea. (13892378)
1962
32
Hypoparathyroidism: a review of the literature and report of two cases in sisters, one with steatorrhea and intestinal pseudo-obstruction. (13919902)
1962
33
Steatorrhea in infants. Report of two cases caused by anatomic defects of the small intestine. (13876606)
1962
34
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (14447714)
1961
35
The relationship of afferent limb stasis and bacterial flora to the production of postgastrectomy steatorrhea. (13706639)
1961
36
Clinical experience with the gluten-free diet in idiopathic steatorrhea. (13824864)
1960
37
Duodenal biopsy in diarrhea and steatorrhea. (13846524)
1960
38
Postgastrectomy steatorrhea; a variant of the blind loop syndrome. (13626926)
1959
39
The radio-iodinated triolein test for steatorrhea. (13538155)
1958
40
Intestinal absorption of iodine 131-labeled triolein and oleic acid in normal subjects and in steatorrhea. (13538156)
1958
41
Idiopathic steatorrhea with mesenteric chyladenectasis: two cases resembling Whipple's disease. (13620004)
1958
42
The folic acid excretion test in the steatorrhea syndrome. (13586545)
1958
43
What is idiopathic steatorrhea. (13469765)
1957
44
Steatorrhea in tropical sprue patients in Puerto Rico. (13470196)
1957
45
The clinical aspects and diagnosis of steatorrhea. (13384034)
1957
46
Steatorrhea and probable tuberculosis with acquired hypogammaglobulinemia. (13372962)
1956
47
A case of megaloblastic anemia associated with steatorrhea and the celiac syndrome. (14392559)
1955
48
Effect of ACTH and cortisone on fat absorption in steatorrhea of various causes. (13244819)
1955
49
Iron metabolism in steatorrhea; the use of radioactive iron in studies of absorption and utilization. (13126182)
1954
50
Steatorrhea following the use of antibiotics. (14863583)
1951

Genetic Variations for Steatorrhea

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Expression for genes affiliated with Steatorrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Steatorrhea

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Pathways for genes affiliated with Steatorrhea

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53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Steatorrhea

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Steatorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1cerulein4410.1ELANE, SCT, CCK
2loxiglumide4410.1SCT, CCK, SST
3caerulein449.9CCK, MLN, SCT
4lafutidine449.9SST, SCT, MLN
5taurodeoxycholate449.8CCK, SCT, CLPS, SST
6bicarbonate449.7SCT, CCK, PNLIP
7trioleoylglycerol449.7APOC2, PNLIP, LPL
8ursodeoxycholic acid44 11 2411.7SCT, CCK, MLN, SLC10A2
9enterostatin449.6CLPS, GCG, CCK
10omeprazole44 28 49 11 2413.6SST, MLN, CCK, SCT
11c-peptide449.5GCG, CCK, SCT, SST
12dtpa449.4GCG, CCK, SST
13caffeine44 49 28 2 11 2414.4ELANE, CFTR, LPL, CCK, SST
14bethanechol44 28 1111.4SST, MLN, CCK, GCG
15pirenzepine44 28 1111.3GCG, SST, CCK
16carbachol44 28 1111.3SST, SCT, CCK, GCG, CFTR
17norepinephrine44 11 2411.3CCK, LPL, ELANE, CFTR, PNLIP
18intralipid449.3LPL, SST, CCK
19cisapride44 28 1111.3MLN, GCG, CCK
20tetrodotoxin44 59 2811.3GCG, CCK, MLN, SCT
21oxyntomodulin44 5910.2SCT, CCK, MLN, GCG, SST
22atropine44 28 1111.1GCG, SCT, SST, MLN, CCK
23thyroxine44 2410.1ELANE, LPL, SST, MLN, SCT
24oleic acid44 28 11 2412.1LPL, PNLIP, SCT, GCG, MTTP
25trypsinogen449.1ELANE, CCK, SCT, PRSS1, CFTR, PNLIP
26pge2449.0ELANE, SST, LPL, SCT, CCK, CFTR
27phosphatidylcholine449.0CLPS, PNLIP, MTTP, LPL, TMPRSS15
28ibmx44 28 5911.0CFTR, SST, LPL, SCT, CCK, GCG
29isoproterenol44 1110.0GCG, ELANE, CFTR, LPL, SCT, SST
30epinephrine44 11 2410.9CFTR, GCG, SST, LPL, ELANE, SCT
31orlistat44 59 1110.9PNLIP, CLPS, LPL, CCK, GCG
32taurocholate448.9LPL, PNLIP, TMPRSS15, CFTR, CCK, SCT
33glycerol44 11 2410.9PNLIP, CFTR, LPL, CCK, GCG
34phospholipid448.8PNLIP, LPL, SCT, MTTP, CLPS, APOC2
35glutamine448.8LPL, ELANE, GCG, CCK, SCT, CFTR
36triacylglycerol448.6PNLIP, GCG, CLPS, MTTP, LPL, APOC2
375-hydroxytryptamine448.6GCG, CFTR, SST, PNLIP, MLN, CCK
38dopamine44 28 11 2411.6SST, CCK, GCG, CFTR, MLN, SCT
39cysteine448.5APOC2, GCG, SLC10A2, SCT, MTTP, PRSS1
40octreotide44 59 28 1111.5SCT, CCK, SST, GCG, PNLIP, ELANE
41fatty acid448.4PNLIP, GCG, APOC2, MTTP, LPL, CLPS
42arginine448.3TMPRSS15, GCG, PRSS1, SST, MLN, CCK
43acetylcholine44 49 28 11 2412.2ELANE, LPL, SST, SCT, CCK, GCG
44adenylate448.2SST, MLN, CFTR, SCT, CCK, GCG
45glutamate448.2PNLIP, ELANE, CFTR, CCK, GCG, SCT
46heparin44 28 11 2411.1GCG, APOC2, MLN, LPL, TMPRSS15, ELANE
47cholesterol44 28 11 2411.1MTTP, CLPS, MLN, SLC10A2, LPL, APOC2
48lipid447.9GCG, APOC2, LPL, TMPRSS15, SCT, MTTP
49glucose447.7GCG, SST, MLN, LPL, SCT, PNLIP
50serine447.6SLC10A2, GCG, PRSS1, APOC2, SCT, TMPRSS15

GO Terms for genes affiliated with Steatorrhea

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16Gene Ontology
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Cellular components related to Steatorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.7LPL, APOC2
2extracellular spaceGO:0056157.9GCG, CCK, APOC2, LPL, PRSS1, SST
3extracellular regionGO:0055765.2ELANE, GCG, CCK, APOC2, SCT, LPL

Biological processes related to Steatorrhea according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:0343719.9LPL, APOC2
2very-low-density lipoprotein particle remodelingGO:0343729.9LPL, APOC2
3lipid digestionGO:0442419.8PNLIP, CLPS
4triglyceride homeostasisGO:0703289.7LPL, APOC2
5lipoprotein metabolic processGO:0421579.7APOC2, LPL, MTTP
6lipoprotein transportGO:0429539.6MTTP, APOC2
7lipid catabolic processGO:0160429.3APOC2, CLPS, PNLIP
8retinoid metabolic processGO:0015239.2PNLIP, CLPS, LPL, APOC2
9phototransduction, visible lightGO:0076039.1APOC2, LPL, CLPS, PNLIP
10response to drugGO:0424939.1CFTR, SST, LPL, APOC2
11proteolysisGO:0065088.8PRSS1, TMPRSS15, CELA3B, CELA1, ELANE
12small molecule metabolic processGO:0442817.7GCG, APOC2, LPL, MTTP, PRSS1, GIF

Molecular functions related to Steatorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:0048069.6LPL, PNLIP
2apolipoprotein bindingGO:0341859.5MTTP, LPL
3hormone activityGO:0051798.7SST, GCG, CCK, SCT, MLN
4serine-type endopeptidase activityGO:0042528.7ELANE, PRSS1, TMPRSS15, CELA3B, CELA1

Products for genes affiliated with Steatorrhea

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  • Antibodies
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Sources for Steatorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet