MCID: STT004
MIFTS: 54

Steatorrhea malady

Gastrointestinal diseases category
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Summaries for Steatorrhea

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Wikipedia:65 Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may also float due to... more...

MalaCards based summary: Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and diarrhea. An important gene associated with Steatorrhea is CELA1 (chymotrypsin-like elastase family, member 1), and among its related pathways are Statin Pathway and Fat digestion and absorption. The compounds taurodeoxycholate and oxyntomodulin have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and colon, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Steatorrhea

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT
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Steatorrhea, Aliases & Descriptions:

Name: Steatorrhea 8 10 44 62
 
Fatty Stool 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:10602
NCIt39 C86917
SNOMED-CT57 66187002
MeSH34 D045602

Related Diseases for Steatorrhea

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Diseases related to Steatorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic steatorrhea31.1PNLIP, PRSS1, CELA3B, CELA1
2diarrhea30.7CFTR, SST, GCG
3zollinger-ellison syndrome30.6SCT, SST
4cholestasis30.2CCK, GCG, SLC10A2
5intestinal disease30.2SST
6intrahepatic cholestasis30.1SCT, SLC10A2
7abetalipoproteinemia30.1LPL, MTTP
8duodenal ulcer30.1SCT, SST, CCK
9exocrine pancreatic insufficiency29.8CCK, CELA1, PNLIP, CFTR, SCT, ELANE
10cystic fibrosis29.7PNLIP, CFTR, SCT, PRSS1, ELANE, CELA3B
11diabetes mellitus29.7SCT, APOC2, LPL, SST, CCK, GCG
12adenocarcinoma29.6PNLIP, SCT, PRSS1, SST, CCK
13obesity29.3PNLIP, CLPS, LPL, CCK, MTTP, GCG
14pancreatitis28.5CELA1, LPL, SST, CCK, GCG, CELA3B
15acute pancreatitis27.8PNLIP, CFTR, SCT, APOC2, TMPRSS15, CLPS
16duodenogastric reflux10.5CCK
17angiodysplasia10.4SST
18somatostatinoma10.4SST
19dumping syndrome10.4GCG, SST
20hypoparathyroidism10.4
21gastroparesis10.3CCK, GCG
22celiac disease10.3
23endocrine gland cancer10.3SST, GCG
24hyperinsulinemic hypoglycemia10.3SST, GCG
25gastroesophageal reflux disease10.3SCT, CCK, GCG
26gastrointestinal system disease10.3SCT, CCK, GCG
27vipoma10.3SCT, SST
28hereditary pancreatitis10.3CFTR, PRSS1
29familial hypertriglyceridemia10.3LPL, SLC10A2
30gallbladder disease10.2CCK, CFTR
31emphysema due to aat deficiency10.2ELANE
32tropical sprue10.2
33duodenitis10.2
34blindness10.2
35gastrinoma10.2SCT, SST, GCG
36cystic kidney10.2CFTR, SCT
37short bowel syndrome10.2SST, CCK, GCG
38atrophic gastritis10.2SCT, SST
39insulinoma10.2SCT, SST, GCG
40peptic ulcer disease10.2SCT, SST, CCK
41hypoglycemia10.2SCT, SST, GCG
42morbid obesity10.2LPL, CCK, GCG
43gastritis10.2CCK, SST, SCT
44aspergillosis10.2ELANE
45cholelithiasis10.2SST, CCK
46type 1 diabetes mellitus10.1SCT, SST, GCG
47hyperinsulinism10.1LPL, SST, GCG
48glucagonoma10.1GCG, CCK, SST, SCT
49neuroendocrine tumor10.1SCT, SST, CCK, GCG
50carcinoid syndrome10.1SCT, SST, CCK, GCG

Graphical network of the top 20 diseases related to Steatorrhea:



Diseases related to steatorrhea

Symptoms for Steatorrhea

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Drugs & Therapeutics for Steatorrhea

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Drug clinical trials:

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Genetic Tests for Steatorrhea

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Anatomical Context for Steatorrhea

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MalaCards organs/tissues related to Steatorrhea:

32
Testes, Bone, Colon, Pancreas, Small intestine, Liver, Bone marrow, Pituitary, Thyroid, Pancreatic islet

Animal Models for Steatorrhea or affiliated genes

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MGI Mouse Phenotypes related to Steatorrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4SLC10A2, MTTP, LPL, CFTR, PNLIP
2MP:00053817.6PNLIP, CFTR, CLPS, SST, GCG, SLC10A2
3MP:00053786.6PNLIP, CFTR, CLPS, LPL, SST, MTTP
4MP:00053765.7SLC10A2, PNLIP, CFTR, SCT, TMPRSS15, CLPS

Publications for Steatorrhea

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Articles related to Steatorrhea:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
Education and imaging. Gastrointestinal: "floating oil droplets in the colonic fluid": colonoscopic findings in a patient with pancreatic exocrine insufficiency and steatorrhea. (21564288)
2011
2
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. (16954337)
2007
3
The incidence, pathogenesis and natural history of steatorrhea after bone marrow transplantation. (12728924)
2003
4
Are minimicrosphere pancrelipase capsules effective enough for the treatment of pancreatic steatorrhea? (11374718)
2001
5
Esophageal impairment in adult celiac disease with steatorrhea. (9707045)
1998
6
Bone mineral density in patients with pancreatic insufficiency and steatorrhea. (9149203)
1997
7
Evaluation of steatorrhea during acute infectious enteritis. (8890096)
1996
8
Steatorrhea in Japanese patients with chronic pancreatitis. (7719419)
1995
9
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. (8113582)
1994
10
Treatment of severe steatorrhea with ox bile in an ileectomy patient with residual colon. (1587199)
1992
11
Fecal fat concentration in the screening of steatorrhea. (1289179)
1992
12
Can diarrhea cause secondary steatorrhea? (1587441)
1992
13
Nancy Slater's saga. Bile salt depletion from a scarred ileum causes steatorrhea. (2377241)
1990
14
Detection of pancreatic steatorrhea by oral pancreatic function tests. (3262493)
1988
15
Steatorrhea and disorders of chylomicron synthesis and secretion. (3277133)
1988
16
Fecal fat concentrations and pancreatic steatorrhea. (3337054)
1988
17
Raised fecal fat concentration is not a valid indicator of pancreatic steatorrhea. (3646827)
1987
18
Effects of metiamide on gastric acid hypersecretion, steatorrhea, and bone-marrow function in a patient with systemic mastocytosis. (980022)
1976
19
Idiopathic hypoparathyroidism and steatorrhea: a new aid in management. (4443861)
1974
20
Acute quadriparesis with mucle spasms related to electrolyte disturbances in steatorrhea. Clinical and biochemical data. (5030181)
1972
21
Influence of medium-chain triglycerides on steatorrhea--in maldigestion, malabsorption and primary exudative enteropathy. (5101522)
1971
22
Parathormone-like effect of magnesium replenishment in steatorrhea. (5409498)
1970
23
Diminished micellar phase lipid in patients with chronic nonalcoholic liver disease and steatorrhea. (5423890)
1970
24
Postgastrectomy steatorrhea. (5456911)
1970
25
Diabetic diarrhea and steatorrhea. Microbiologic and clinical observations. (5412488)
1970
26
A case of coexisting duodenal uceration and idiopathic steatorrhea. (5686665)
1968
27
Hyperthyroidism and steatorrhea in an adolescent. Report of a case. (4165198)
1967
28
Ultrastructural studies of the human Giardia lamblia and subjacent jejunal mucosa in a subject with steatorrhea. (4164029)
1967
29
Rapid diagnosis of steatorrhea by external counting of abdomen after iodine-131-labeled fat administration. (5958069)
1966
30
Neomycin-induced steatorrhea. A preliminary report on the in vivo hydrolysis of a long-chain unsaturated fat. (15214379)
1966
31
LABORATORY AIDS IN DIAGNOSIS OF STEATORRHEA. (14107210)
1964
32
Intestinal volvulus in idiopathic steatorrhea. (13998948)
1963
33
Studies of the mechanism of postgastrectomy steatorrhea. (14001296)
1963
34
DIARRHEA AND STEATORRHEA DUE TO A LARGE SOLITARY DUODENAL DIVERTICULUM. REPORT OF A CASE. (14083820)
1963
35
Steatorrhea due to chronic pancreatitis and pancreatic atrophy following gastric surgery. (14007336)
1962
36
Limitations of the I-131-labeled triolein tests in the diagnosis of steatorrhea. (14475017)
1962
37
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (14447714)
1961
38
On the pathogenesis of diabetic steatorrhea. (13918368)
1961
39
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (13736665)
1961
40
Clinical experience with the gluten-free diet in idiopathic steatorrhea. (13824864)
1960
41
WHEAT gluten in adult steatorrhea. (13566698)
1958
42
What is idiopathic steatorrhea. (13469765)
1957
43
Small intestinal lesions with steatorrhea in diffuse systemic sclerosis (scleroderma). (13405166)
1957
44
Steatorrhea in tropical sprue patients in Puerto Rico. (13470196)
1957
45
Idiopathic steatorrhea. (13266826)
1955
46
A case of megaloblastic anemia associated with steatorrhea and the celiac syndrome. (14392559)
1955
47
Spruce vs. pancreatogenous steatorrhea; an evaluation of the small bowel study as an aid in differentiation. (13204607)
1954
48
Diseases of intestinal absorption; idiopathic steatorrhea. (13114607)
1954
49
Glucose absorption from the duodenum in patients with steatorrhea. (14943723)
1952
50
Primary systemic amyloidosis simulating constrictive pericarditis; with steatorrhea and hyperesthesia. (18879125)
1948

Variations for Steatorrhea

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Expression for genes affiliated with Steatorrhea

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Expression patterns in normal tissues for genes affiliated with Steatorrhea

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Pathways for genes affiliated with Steatorrhea

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Pathways related to Steatorrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2APOC2, LPL, MTTP
2
Show member pathways
9.2CLPS, PNLIP, MTTP
39.0CFTR, CCK, GCG
48.7CELA3B, PNLIP, CFTR, PRSS1
5
Show member pathways
8.6PRSS1, GCG, CCK, SST, SCT
6
Show member pathways
8.5PNLIP, APOC2, LPL, CLPS
7
Show member pathways
8.2LPL, PNLIP, APOC2, CLPS, MTTP
8
Show member pathways
6.9SLC10A2, GCG, MTTP, LPL, PRSS1, CLPS
9
Show member pathways
6.8CLPS, APOC2, SCT, PNLIP, LPL, SST

Compounds for genes affiliated with Steatorrhea

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Compounds related to Steatorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 401)
idCompoundScoreTop Affiliating Genes
1taurodeoxycholate449.7SCT, CLPS, SST, CCK
2oxyntomodulin44 6110.2CCK, SCT, SST, GCG
3TG(18:3(9Z,12Z,15Z)/18:1(9Z)/18:3(9Z,12Z,15Z))[iso3]249.0LPL, MTTP, APOC2, PNLIP
4TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:5(7Z,10Z,13Z,16Z,19Z))[iso3]249.0PNLIP, APOC2, LPL, MTTP
5TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:4(7Z,10Z,13Z,16Z))[iso3]249.0PNLIP, APOC2, LPL, MTTP
6TG(18:3(9Z,12Z,15Z)/18:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))[iso6]249.0MTTP, LPL, APOC2, PNLIP
7TG(18:3(9Z,12Z,15Z)/18:1(9Z)/22:5(7Z,10Z,13Z,16Z,19Z))[iso6]249.0MTTP, LPL, APOC2, PNLIP
8TG(18:2(9Z,12Z)/18:1(9Z)/18:3(9Z,12Z,15Z))[iso6]249.0LPL, APOC2, PNLIP, MTTP
9TG(18:2(9Z,12Z)/18:1(9Z)/20:2(11Z,14Z))[iso6]249.0MTTP, LPL, APOC2, PNLIP
10TG(18:2(9Z,12Z)/18:1(9Z)/20:3(8Z,11Z,14Z))[iso6]249.0MTTP, LPL, APOC2, PNLIP
11TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:5(5Z,8Z,11Z,14Z,17Z))[iso3]249.0MTTP, LPL, APOC2, PNLIP
12TG(20:4(5Z,8Z,11Z,14Z)/18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[iso6]249.0MTTP, LPL, APOC2, PNLIP
13TG(22:5(7Z,10Z,13Z,16Z,19Z)/16:0/22:5(7Z,10Z,13Z,16Z,19Z))[iso3]249.0PNLIP, APOC2, LPL, MTTP
14TG(22:5(7Z,10Z,13Z,16Z,19Z)/16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[iso6]249.0MTTP, LPL, APOC2, PNLIP
15TG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[iso3]249.0MTTP, LPL, APOC2, PNLIP
16TG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:3(9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[iso3]248.9MTTP, LPL, APOC2, PNLIP
17TG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[iso3]248.9MTTP, LPL, APOC2, PNLIP
18TG(20:4(5Z,8Z,11Z,14Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z))[iso6]248.9MTTP, LPL, APOC2, PNLIP
19TG(20:4(5Z,8Z,11Z,14Z)/18:2(9Z,12Z)/20:5(5Z,8Z,11Z,14Z,17Z))[iso6]248.9MTTP, LPL, APOC2, PNLIP
20TG(20:5(5Z,8Z,11Z,14Z,17Z)/18:3(9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[iso6]248.9MTTP, LPL, APOC2, PNLIP
21TG(15:0/18:1(9Z)/18:2(9Z,12Z))[iso6]248.9MTTP, LPL, APOC2, PNLIP
22TG(16:0/16:0/18:3(9Z,12Z,15Z))[iso3]248.9PNLIP, APOC2, LPL, MTTP
23TG(16:1(9Z)/14:0/16:1(9Z))[iso3]248.9MTTP, LPL, APOC2, PNLIP
24TG(16:1(9Z)/14:0/18:1(11Z))[iso6]248.9MTTP, LPL, APOC2, PNLIP
25TG(16:1(9Z)/18:0/18:1(11Z))[iso6]248.9MTTP, LPL, APOC2, PNLIP
26TG(18:1(11Z)/14:0/18:1(11Z))[iso3]248.9MTTP, LPL, APOC2, PNLIP
27TG(15:0/18:1(9Z)/18:3(9Z,12Z,15Z))[iso6]248.8MTTP, LPL, APOC2, PNLIP
28TG(15:0/18:2(9Z,12Z)/16:0)[iso6]248.8MTTP, LPL, APOC2, PNLIP
29TG(15:0/18:2(9Z,12Z)/18:2(9Z,12Z))[iso3]248.8MTTP, LPL, APOC2, PNLIP
30TG(18:1(11Z)/14:0/18:1(9Z))[iso6]248.8MTTP, LPL, APOC2, PNLIP
31TG(18:1(9Z)/16:0/18:3(9Z,12Z,15Z))[iso6]248.8PNLIP, APOC2, LPL, MTTP
32TG(18:1(9Z)/18:1(9Z)/20:2(11Z,14Z))[iso3]248.7MTTP, LPL, APOC2, PNLIP
33TG(18:1(9Z)/18:1(9Z)/20:3(5Z,8Z,11Z))[iso3]248.7MTTP, LPL, APOC2, PNLIP
34TG(18:1(9Z)/18:1(9Z)/20:3(8Z,11Z,14Z))[iso3]248.7MTTP, LPL, APOC2, PNLIP
35TG(18:2(9Z,12Z)/18:1(9Z)/18:3(6Z,9Z,12Z))[iso6]248.6MTTP, LPL, APOC2, PNLIP
36TG(18:1(9Z)/14:0/20:4(5Z,8Z,11Z,14Z))[iso6]248.6MTTP, LPL, APOC2, PNLIP
37trypsinogen448.6TMPRSS15, PNLIP, CFTR, SCT, CCK, ELANE
38TG(18:1(9Z)/14:0/18:1(9Z))[iso3]248.5MTTP, LPL, APOC2, PNLIP
39oleic acid44 28 24 1111.4GCG, PNLIP, SCT, LPL, MTTP
40taurocholate448.4SLC10A2, CCK, LPL, TMPRSS15, SCT, CFTR
41ibmx44 61 2810.4SCT, GCG, CCK, SST, LPL, CFTR
42octreotide44 61 28 1111.3GCG, CCK, SST, SCT, ELANE, PNLIP
43TG(18:1(9Z)/14:0/18:2(9Z,12Z))[iso6]248.3MTTP, LPL, APOC2, PNLIP
44isoproterenol44 119.3SCT, CFTR, GCG, SST, LPL, ELANE
45orlistat44 61 1110.3CCK, LPL, CLPS, PNLIP, GCG
46acetylcholine44 50 28 24 1112.0SCT, SST, GCG, CCK, LPL, ELANE
47triacylglycerol447.8CLPS, GCG, MTTP, LPL, APOC2, PNLIP
48norepinephrine44 24 119.4CFTR, SCT, LPL, CCK, GCG, PNLIP
49glutamate447.4GCG, CCK, SST, LPL, ELANE, SCT
50lipid447.0SCT, APOC2, PNLIP, GCG, SLC10A2, CLPS

GO Terms for genes affiliated with Steatorrhea

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Cellular components related to Steatorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.4LPL, APOC2
2very-low-density lipoprotein particleGO:0343619.2APOC2, LPL
3extracellular spaceGO:0056158.1GCG, CCK, SST, LPL, APOC2
4extracellular regionGO:0055766.0GCG, PNLIP, SCT, APOC2, CLPS, PRSS1

Biological processes related to Steatorrhea according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:0343719.6LPL, APOC2
2lipid digestionGO:0442419.6CLPS, PNLIP
3very-low-density lipoprotein particle remodelingGO:0343729.5APOC2, LPL
4triglyceride homeostasisGO:0703289.5LPL, APOC2
5lipoprotein transportGO:0429539.4MTTP, APOC2
6lipoprotein metabolic processGO:0421579.4APOC2, LPL, MTTP
7lipid catabolic processGO:0160429.1CLPS, APOC2, PNLIP
8retinoid metabolic processGO:0015238.7LPL, CLPS, APOC2, PNLIP
9response to drugGO:0424938.7SST, LPL, APOC2, CFTR
10phototransduction, visible lightGO:0076038.7LPL, CLPS, APOC2, PNLIP
11small molecule metabolic processGO:0442817.1PNLIP, APOC2, CLPS, PRSS1, LPL, MTTP

Molecular functions related to Steatorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein bindingGO:0341859.4MTTP, LPL
2triglyceride lipase activityGO:0048069.3LPL, PNLIP
3serine-type endopeptidase activityGO:0042528.9CELA1, CELA3B, ELANE, PRSS1, TMPRSS15
4hormone activityGO:0051798.7SCT, SST, CCK, GCG

Products for genes affiliated with Steatorrhea

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  • Antibodies
  • Proteins
  • Lysates

Sources for Steatorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet