MCID: STT004
MIFTS: 41

Steatorrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Steatorrhea

MalaCards integrated aliases for Steatorrhea:

Name: Steatorrhea 12 28 51 41 14
Fatty Stool 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10602
MeSH 41 D045602
NCIt 46 C86917
UMLS 69 C0038238

Summaries for Steatorrhea

MalaCards based summary : Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and zollinger-ellison syndrome. An important gene associated with Steatorrhea is PNLIP (Pancreatic Lipase), and among its related pathways/superpathways are Lipoprotein metabolism and Bile secretion. The drugs Pancrelipase and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and colon, and related phenotype is homeostasis/metabolism.

Wikipedia : 72 Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may be bulky and difficult... more...

Related Diseases for Steatorrhea

Diseases related to Steatorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 pancreatic steatorrhea 32.9 CCK CELA1 PNLIP SCT
2 zollinger-ellison syndrome 30.2 SCT SST
3 cystic fibrosis 29.7 CFTR PNLIP SCT
4 diarrhea 29.7 CCK SST TMPRSS15
5 pancreatic agenesis 1 29.4 CFTR PNLIP SCT
6 exocrine pancreatic insufficiency 29.3 CCK CFTR PNLIP SCT
7 duodenal ulcer 29.3 CCK SCT SST
8 pancreatitis 28.5 APOC2 CCK CFTR PNLIP SCT SST
9 acute pancreatitis 27.8 APOC2 CCK PNLIP SCT SST TMPRSS15
10 celiac disease 1 11.3
11 tropical sprue 11.3
12 blind loop syndrome 11.2
13 glucose intolerance 11.2
14 bile acid malabsorption, primary 11.0
15 bile acid synthesis defect, congenital, 2 10.9
16 bile acid synthesis defect, congenital, 1 10.9
17 hypobetalipoproteinemia, familial, 1 10.9
18 familial lipoprotein lipase deficiency 10.3 APOC2 PNLIP
19 hyperlipoproteinemia, type iv 10.3 APOC2 SLC10A2
20 glucagonoma 10.3 SCT SST
21 hyperinsulinemic hypoglycemia, familial, 2 10.2 SCT SST
22 angiodysplasia 10.2 SCT SST
23 dumping syndrome 10.2 SCT SST
24 biliary dyskinesia 10.2 CCK SCT
25 duodenal disease 10.2 CCK SCT
26 duodenal gastrinoma 10.2 CCK SCT
27 gastrinoma 10.2 SCT SST
28 recurrent acute pancreatitis 10.2 CFTR SCT
29 pancreatic gastrinoma 10.2 SCT SST
30 postcholecystectomy syndrome 10.1 CCK SST
31 bile duct disease 10.1 CCK SLC10A2
32 hypoparathyroidism 10.1
33 biliary tract disease 10.1 CCK SLC10A2
34 secretory diarrhea 10.1 CFTR SST
35 functional gastric disease 10.1 CCK SST
36 rasmussen encephalitis 10.0 CCK SST
37 short bowel syndrome 10.0 CCK SST
38 diabetes mellitus 10.0
39 duodenitis 10.0
40 dyspepsia 10.0 CCK SST
41 fibrosis of extraocular muscles, congenital, 1 10.0
42 stomach disease 9.9 CCK SST
43 chylomicron retention disease 9.9 MTTP SLC10A2
44 duodenogastric reflux 9.9 CCK SCT SST
45 pancreatic cholera 9.9 CCK SCT SST
46 gastrointestinal system disease 9.9 CCK SCT SST
47 megalencephaly 9.9 CCK SST
48 alcoholic pancreatitis 9.9 CCK CFTR SCT
49 lymphoma 9.8
50 cholelithiasis 9.8 CCK SST

Graphical network of the top 20 diseases related to Steatorrhea:



Diseases related to Steatorrhea

Symptoms & Phenotypes for Steatorrhea

MGI Mouse Phenotypes related to Steatorrhea:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 APOC2 CCK CFTR MTTP PNLIP SLC10A2

Drugs & Therapeutics for Steatorrhea

Drugs for Steatorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53608-75-6
2 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
3 pancreatin Phase 4,Phase 3,Phase 2,Phase 1
4
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
5 Antacids Phase 3
6 Anti-Ulcer Agents Phase 3
7 Proton pump inhibitors Phase 3
8 Pharmaceutical Solutions Phase 2, Phase 3
9
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
10 Hypoglycemic Agents Phase 2
11 insulin Phase 2
12 Insulin, Globin Zinc Phase 2
13
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
14
Phytonadione Approved, Investigational, Nutraceutical Phase 1 84-80-0 5284607 4812
15 Antifibrinolytic Agents Phase 1
16 Coagulants Phase 1
17 Hemostatics Phase 1
18 Micronutrients Phase 1
19 Trace Elements Phase 1
20 Vitamins Phase 1
21 Menaquinone Nutraceutical Phase 1
22 naphthoquinone Nutraceutical Phase 1
23 Vitamin K Nutraceutical Phase 1
24
Nicotine Approved 54-11-5 89594 942
25
Teriparatide Approved, Investigational 52232-67-4 16133850
26
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
27 Bile Acids and Salts
28 Antibodies
29 Immunoglobulins
30 Cholic Acids
31 Bone Density Conservation Agents
32 Calcium, Dietary
33 glucocorticoids

Interventional clinical trials:

(show all 29)

# Name Status NCT ID Phase Drugs
1 Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT01327703 Phase 4 Panzytrat® 25,000;Kreon® 25,000
2 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
3 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
4 Pancreatic Enzyme Suppletion in Pancreatic Cancer Withdrawn NCT01401387 Phase 4
5 Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea Completed NCT00559364 Phase 3 Viokase® 16;Placebo;Proton pump inhibitor (PPI);Omeprazole
6 Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) Completed NCT00880100 Phase 3 Ultrase® MT12
7 Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis Completed NCT00432861 Phase 3 PANCRECARB® (pancrelipase);Placebo
8 Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) Completed NCT00408317 Phase 3 Ultrase® MT20;Placebo
9 A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency Completed NCT00662675 Phase 3 Pancrease MT 10.5, or MT 21;Placebo for Pancrease MT 10.5 or MT 21
10 Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) Completed NCT00513682 Phase 3 Ultrase® MT20
11 Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation Active, not recruiting NCT01967888 Phase 2, Phase 3 Reparixin;Placebo
12 Creon in HIV Patients With Steatorrhea Terminated NCT00623025 Phase 3 Creon 25000;Placebo
13 Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs Withdrawn NCT01228643 Phase 3
14 An Effectiveness, Safety, and Palatability Study of Pancrelipase Microtablets in Infants and Toddlers With Cystic Fibrosis and Fat Malabsorption Completed NCT00217204 Phase 2 Pancrelipase microtablets
15 Tolerance and Digestibility of a New Formula in Healthy Infants Completed NCT01184378 Phase 2
16 An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI) Completed NCT00559052 Phase 2 VIOKASE 16
17 Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality Completed NCT00782795 Phase 2 Pioglitazone;Placebo
18 A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI) Completed NCT00676702 Phase 1 Pancrelipase in combination with Ensure Plus
19 Comparison of Feasibility Between Internal and External Pancreatic Drainage in Pancreaticoduodenectomy Unknown status NCT01023594
20 Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic Fibrosis Completed NCT00006063 pancrelipase with bicarbonate
21 Effect of Potato Fiber on Appetite and Fecal Fat Excretion Completed NCT02957318
22 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
23 Horton & Maizy Pilot Study for Resistant to Starch Completed NCT01338571
24 Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis Completed NCT01527084
25 The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms" Completed NCT02121626
26 Celiac Disease Diagnosis in Patients With Weakly Positive Serum Anti-Transglutaminase: Duodenal Anti-Endomysium Assay. Recruiting NCT02242123
27 The REPLACE Registry Recruiting NCT03115086
28 Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders Recruiting NCT02252679
29 The Natural History of Chronic Pancreatitis Active, not recruiting NCT03324698

Search NIH Clinical Center for Steatorrhea

Cochrane evidence based reviews: steatorrhea

Genetic Tests for Steatorrhea

Genetic tests related to Steatorrhea:

# Genetic test Affiliating Genes
1 Steatorrhea 28

Anatomical Context for Steatorrhea

MalaCards organs/tissues related to Steatorrhea:

38
Testes, Bone, Colon, Pancreatic Islet, Pancreas, Liver, Small Intestine

Publications for Steatorrhea

Articles related to Steatorrhea:

(show top 50) (show all 314)
# Title Authors Year
1
Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass. ( 28089681 )
2017
2
RE: Steatorrhea, Hyperoxaluria andA Colonic Hyperproliferation After Roux-en-Y Gastric Bypass. ( 28881188 )
2017
3
Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients. ( 26877248 )
2016
4
Dietary green-plant thylakoids decrease gastric emptying and gut transit, promote changes in the gut microbial flora, but does not cause steatorrhea. ( 27777602 )
2016
5
50 years ago in the journal of pediatrics: disaccharidase deficiencies with steatorrhea. ( 24359902 )
2014
6
Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection. ( 23395568 )
2013
7
Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate. ( 23499748 )
2013
8
Education and imaging. Gastrointestinal: "floating oil droplets in the colonic fluid": colonoscopic findings in a patient with pancreatic exocrine insufficiency and steatorrhea. ( 21564288 )
2011
9
Pancreatic lipomatosis with massive steatorrhea. ( 22081194 )
2011
10
Chronic pancreatitis and persistent steatorrhea: what is the correct dose of enzymes? ( 21377551 )
2011
11
Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea. ( 20146370 )
2010
12
Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. ( 19034041 )
2009
13
Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. ( 19238028 )
2009
14
Spontaneous exocrine pancreas hypoplasia in specific pathogen-free C3HeB/FeJ and 101/H mouse pups causes steatorrhea and runting. ( 17536623 )
2007
15
An enteric-coated high-buffered pancrelipase reduces steatorrhea in patients with cystic fibrosis: a prospective, randomized study. ( 16863712 )
2006
16
Unresponsive or non-compliant steatorrhea in cystic fibrosis? ( 16765107 )
2006
17
The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis. ( 16868481 )
2006
18
Does pancreatic elastase-1 in stools predict steatorrhea in type 1 diabetes? ( 16505538 )
2006
19
The incidence, pathogenesis and natural history of steatorrhea after bone marrow transplantation. ( 12728924 )
2003
20
High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. ( 14560984 )
2003
21
Rethinking growth failure in Alagille syndrome: the role of dietary intake and steatorrhea. ( 12394373 )
2002
22
Are minimicrosphere pancrelipase capsules effective enough for the treatment of pancreatic steatorrhea? ( 11374718 )
2001
23
Massive steatorrhea in a child due to isolated pancreatic hypoplasia. ( 11721073 )
2001
24
Association between steatorrhea, growth, and immunologic status in children with perinatally acquired HIV infection. ( 11177089 )
2001
25
Positive results on tests for steatorrhea in persons consuming olestra potato chips. ( 10681282 )
2000
26
A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. ( 10950038 )
2000
27
Fecal weight determination can unfortunately not replace unpopular and costly fecal fat estimation in the diagnosis of steatorrhea. ( 10211425 )
1999
28
Study on pancreatic insufficiency (chronic pancreatitis) and steatorrhea in Japanese patients with low fat intake. ( 10026440 )
1999
29
Prevalence and significance of steatorrhea in patients with active Graves' disease. ( 9672342 )
1998
30
Esophageal impairment in adult celiac disease with steatorrhea. ( 9707045 )
1998
31
Steatorrhea cannot be excluded where there is a fecal weight below 0.200 kg per day and a high fecal consistency. ( 9890341 )
1998
32
Determination of fecal fat concentration by near infrared spectrometry for the screening of pancreatic steatorrhea. ( 9520087 )
1998
33
Steatorrhea and weight loss in a 72-year-old man: primary biliary cirrhosis? Celiac disease? Bacterial overgrowth? What else? ( 9820402 )
1998
34
Acid steatocrit: a simple, rapid gravimetric method to determine steatorrhea. ( 9399770 )
1997
35
Can pancreatic steatorrhea be diagnosed without chemical analysis? ( 9387033 )
1997
36
Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea? ( 9178698 )
1997
37
Bone mineral density in patients with pancreatic insufficiency and steatorrhea. ( 9149203 )
1997
38
Pancreatic steatorrhea, malabsorption, and nutrition biochemistry: a comparison of Japanese, European, and American patients with chronic pancreatitis. ( 9163777 )
1997
39
Evaluation of steatorrhea during acute infectious enteritis. ( 8890096 )
1996
40
Steatorrhea: a common manifestation in patients with HIV/AIDS. ( 8878143 )
1996
41
Steatorrhea in Japanese patients with chronic pancreatitis. ( 7719419 )
1995
42
Intestinal lymphangiectasia in a patient with autoimmune polyglandular disease type I and steatorrhea. ( 7883852 )
1995
43
Steatocrit: a reliable semiquantitative method for detection of steatorrhea. ( 7806830 )
1994
44
Fat-soluble vitamin concentration in chronic alcohol-induced pancreatitis. Relationship with steatorrhea. ( 8174441 )
1994
45
Octreotide decreases biliary and pancreatic exocrine function, and induces steatorrhea in healthy subjects. ( 7827373 )
1994
46
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. ( 8113582 )
1994
47
Fecal alpha 1-antitrypsin clearance in the differential diagnosis of steatorrhea. ( 1300854 )
1992
48
Can diarrhea cause secondary steatorrhea? ( 1587441 )
1992
49
Fecal fat concentration in the screening of steatorrhea. ( 1289179 )
1992
50
Treatment of severe steatorrhea with ox bile in an ileectomy patient with residual colon. ( 1587199 )
1992

Variations for Steatorrhea

Expression for Steatorrhea

Search GEO for disease gene expression data for Steatorrhea.

Pathways for Steatorrhea

GO Terms for Steatorrhea

Cellular components related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOC2 CCK CELA1 PNLIP SCT SST
2 extracellular space GO:0005615 9.1 APOC2 CCK CELA1 PNLIP SCT SST

Biological processes related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.26 APOC2 MTTP
2 retinoid metabolic process GO:0001523 9.16 APOC2 PNLIP
3 lipoprotein transport GO:0042953 8.96 APOC2 MTTP
4 chylomicron assembly GO:0034378 8.62 APOC2 MTTP

Molecular functions related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CCK SCT SST

Sources for Steatorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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