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MCID: STT004
MIFTS: 49

Steatorrhea malady
20 genes, 9 tissues, 228 related diseases, clinical trials.

Summaries for Steatorrhea

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64Wikipedia, 33MalaCards
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Wikipedia:64 Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may also float due to... more...

MalaCards: Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and pancreatitis, chronic. An important gene associated with Steatorrhea is CELA1 (chymotrypsin-like elastase family, member 1), and among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Digestion of dietary lipid. The compounds cerulein and loxiglumide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, small intestine and colon, and related mouse phenotypes are digestive/alimentary and growth/size.

Aliases & Classifications for Steatorrhea

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8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

steatorrhea 8 10 45 61
fatty stool 8


External Ids:

Disease Ontology8 DOID:10602
NCIt40 C86917
SNOMED-CT57 66187002
MeSH35 D045602

Related Diseases for Steatorrhea

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17GeneCards, 18GeneDecks
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Diseases related to Steatorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic steatorrhea31.0PRSS1, PNLIP, CELA3B, CELA1
2pancreatitis, chronic30.5GCG, CCK, APOC2, SCT, LPL, PRSS1
3cystic fibrosis30.4SCT, LPL, PRSS1, CFTR, PNLIP, CELA3B
4celiac disease30.4CCK
5exocrine pancreatic insufficiency30.3ELANE, CELA1, CELA3B, PNLIP, CFTR, SCT
6zollinger-ellison syndrome30.1SCT, SST
7abetalipoproteinemia29.7MTTP, LPL
8duodenal ulcer29.7CCK, SCT, SST
9intrahepatic cholestasis29.7SLC10A2, SCT
10adenoma29.7SST, SCT, GCG
11irritable bowel syndrome29.7MLN, CCK
12adenocarcinoma29.7CCK, SCT, PRSS1, SST, PNLIP
13acute pancreatitis29.6CCK, APOC2, SCT, LPL, SST, CLPS
14hypoparathyroidism10.3
15tropical sprue10.2
16whipple disease10.1
17systemic scleroderma10.1
18hyperparathyroidism10.0SCT
19cholesterol ester storage disease10.0PNLIP
20glossitis10.0GCG
21intestinal pseudo-obstruction10.0SST
22intestinal obstruction10.0CFTR
23cholangitis10.0CFTR
24polycystic ovary syndrome10.0GCG
25angiodysplasia10.0SST
26cholangiocarcinoma10.0PNLIP, SCT
27somatostatinoma10.0SST
28lipoprotein lipase deficiency10.0LPL
29familial lipoprotein lipase deficiency10.0LPL
30acromegaly10.0SST, CCK
31neuroendocrine tumor10.0GCG, SST
32hyperinsulinemic hypoglycemia10.0SCT, SST
33anorexia nervosa10.0GCG, CCK
34endocrine gland cancer10.0GCG, SST
35hereditary pancreatitis10.0PRSS1, CFTR
36cholestasis10.0SLC10A2, CCK, GCG
37cholelithiasis10.0SST, CCK
38vipoma10.0SST, SCT
39gastrinoma10.0GCG, SCT, SST
40ileus10.0MLN
41peptic ulcer10.0CCK, SCT, SST
42familial hypertriglyceridemia10.0LPL, SLC10A2
43short bowel syndrome10.0GCG, CCK, SST
44cushing's syndrome10.0SST
45respiratory failure10.0CCK, CFTR
46cystic kidney10.0CFTR, SCT
47morbid obesity10.0GCG, CCK, LPL
48atrophic gastritis10.0SST, SCT
49glucagonoma10.0SST, SCT, CCK, GCG
50hyperlipoproteinemia type v10.0APOC2, LPL

Graphical network of the top 20 diseases related to Steatorrhea:



Diseases related to steatorrhea

Clinical Features for Steatorrhea

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Drugs & Therapeutics for Steatorrhea

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Steatorrhea

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Anatomical Context for Steatorrhea

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33MalaCards
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MalaCards organs/tissues related to Steatorrhea:

33
Bone marrow, Small intestine, Colon, Liver, Pancreas, Thyroid, B cells, Pancreatic islet, Pituitary

Animal Models for Steatorrhea or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Steatorrhea:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
digestive/alimentary phenotype
MP:00053818.1GCG, SST, CLPS, CFTR, PNLIP, SLC10A2
2
growth/size phenotype
MP:00053787.4GCG, LPL, MTTP, SST, CLPS, CFTR
3
homeostasis/metabolism phenotype
MP:00053766.4ELANE, COX4I2, GCG, CCK, SCT, LPL

Publications for Steatorrhea

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51PubMed
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Articles related to Steatorrhea:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection. (23395568)
2013
2
Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea. (20146370)
2010
3
An enteric-coated high-buffered pancrelipase reduces steatorrhea in patients with cystic fibrosis: a prospective, randomized study. (16863712)
2006
4
Esophageal impairment in adult celiac disease with steatorrhea. (9707045)
1998
5
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. (8113582)
1994
6
Nancy Slater's saga. Bile salt depletion from a scarred ileum causes steatorrhea. (2377241)
1990
7
Detection of pancreatic steatorrhea by oral pancreatic function tests. (3262493)
1988
8
Value of a spectroscopic "fecalogram" in determining the etiology of steatorrhea. (3338185)
1988
9
Duodenal instillation of pancreatin does not abolish steatorrhea in patients with pancreatic insufficiency. (3168697)
1988
10
Hypocalcemia and steatorrhea--clues to etiology. (6297862)
1983
11
Screening for steatorrhea. (447023)
1979
12
Effects of metiamide on gastric acid hypersecretion, steatorrhea, and bone-marrow function in a patient with systemic mastocytosis. (980022)
1976
13
Relationship between disturbances of micellar formation and steatorrhea. (964034)
1976
14
Steatorrhea and azotorrhea and their relation to growth and nutrition in adolescents and young adults with cystic fibrosis. (4811984)
1974
15
Sudden onset of steatorrhea due to surgical occlusion of the main pancreatic duct. Report of a case. (4415982)
1974
16
Postgastrectomy steatorrhea. (5456911)
1970
17
Diabetic diarrhea and steatorrhea. Microbiologic and clinical observations. (5412488)
1970
18
Use of 3H-labeled triether, a nonabsorbable oil-phase marker, to estimate fat absorption in rats with cholestyramine-induced steatorrhea. (5441248)
1970
19
A case of coexisting duodenal uceration and idiopathic steatorrhea. (5686665)
1968
20
Steatorrhea and the measurement of fecal fat. (5663096)
1968
21
Moniliasis--an internal disease? Three cases of idiopathic hypoparathyroidism with moniliasis, steatorrhea, primary amenorrhea and pernicious anemia. (5908972)
1966
22
Varieties of steatorrhea. (5917827)
1966
23
A PATIENT WITH STEATORRHEA AND RAYNAUD'S PHENOMENON. (14341182)
1965
24
STEATORRHEA--INVESTIGATION AND MANAGEMENT. (14338825)
1965
25
LACTOSE INTOLERANCE AS A CAUSE OF STEATORRHEA IN AN ADULT. (14070420)
1963
26
INTESTINAL ABSORPTION OF TRITUM-LABELLED FOLIC ACID IN IDIOPATHIC STEATORRHEA: EFFECT OF A GLUTENFREE DIET. (14077269)
1963
27
Postvagotomy and gastectomy-nutrition and steatorrhea. (13882605)
1962
28
Experimental steatorrhea induced in man by bile acid sequestrant. (13712112)
1961
29
Studies on idiopathic steatorrhea with fat labeled (I-131). (14406577)
1960
30
Steatorrhea in adults. (14440081)
1960
31
Histopathologic studies in steatorrhea. (14446023)
1960
32
Further observations on postgastrectomy steatorrhea: the effect of high carbohydrate intake and of hydrochloric acid administration on fat absorption. (13841170)
1959
33
Emotion and personality in the etiology of steatorrhea. (13649642)
1959
34
Chronic relapsing pancreatitis apparently initiated by trauma: report of a case with eventual development of pancreatic calcification, diabetes mellitus, pancreatic steatorrhea, and duodenal ulcer with hematemesis and melena. (13826234)
1959
35
STUDIES on postgastrectomy steatorrhea. (13493907)
1958
36
Steatorrhea with diabetes: a case report. (13545744)
1958
37
Small intestinal lesions with steatorrhea in diffuse systemic sclerosis (scleroderma). (13405166)
1957
38
Steatorrhea. (13410888)
1957
39
Blood carotene and steatorrhea. (13469771)
1957
40
Tocopherol deficiency in infants and children with steatorrhea. (13486616)
1956-1957
41
Blood changes and avitaminosis in idiopathic steatorrhea. (13079663)
1953
42
Glucose absorption from the duodenum in patients with steatorrhea. (14943723)
1952
43
The comparative absorption of vitamin A from a water-miscible and an oily preparation by normal human adults and patients with steatorrhea. (15436866)
1950
44
Chronic pancreatitis with steatorrhea following mumps with acute pancreatitis. (15432419)
1950
45
The clinical and roentgenological findings in steatorrhea of varying etiology. (15413597)
1950
46
Correction of steatorrhea in bile fistula dogs by frequent return of bile. (18134035)
1949
47
Steatorrhea in diabetes mellitus. (18875217)
1948
48
Steatorrhea. (20284075)
1947
49
METABOLISM IN IDIOPATHIC STEATORRHEA. I. THE INFLUENCE OF DIETARY AND OTHER FACTORS ON LIPID AND MINERAL BALANCE. (16694631)
1939
50
METABOLISM IN IDIOPATHIC STEATORRHEA. II. EFFECT OF LIVER EXTRACT AND VITAMIN D ON CALCIUM, PHOSPHORUS, NITROGEN, AND LIPID BALANCES. (16694632)
1939

Genetic Variations for Steatorrhea

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Expression for genes affiliated with Steatorrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Steatorrhea

Search GEO for disease gene expression data for Steatorrhea.

Pathways for genes affiliated with Steatorrhea

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54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
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Pathways related to Steatorrhea according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cobalamin (Cbl, vitamin B12) transport and metabolism54
9.9GIF, PRSS1
2
Digestion of dietary lipid54
9.6CLPS, PNLIP
3
Statin Pathway, Pharmacodynamics50
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9.5APOC2, LPL, MTTP
4
Selected targets of CREB112
9.4CFTR, CCK, GCG
5
Fat digestion and absorption30
9.4PNLIP, CLPS, MTTP
6
triacylglycerol degradation38
9.4PNLIP, ABHD6
7
Visual phototransduction54
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8.9APOC2, LPL, CLPS, PNLIP
8
Pancreatic secretion30
8.7PRSS1, CFTR, PNLIP, CELA3B
9
Lipoprotein metabolism54
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8.7PNLIP, CLPS, MTTP, LPL, APOC2
10
Class A/1 (Rhodopsin-like receptors)54
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8.5GCG, CCK, SCT, MLN, PRSS1, SST
11
Metabolism54
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8.1COX4I2, GCG, APOC2, LPL, MTTP, PRSS1
12
Signaling by GPCR54
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7.2GCG, CCK, APOC2, SCT, LPL, MLN

Compounds for genes affiliated with Steatorrhea

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45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Steatorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1cerulein4510.1CCK, SCT, ELANE
2loxiglumide4510.1CCK, SCT, SST
3caerulein459.9CCK, SCT, MLN
4lafutidine459.9SCT, MLN, SST
5taurodeoxycholate459.8CLPS, SST, SCT, CCK
6bicarbonate459.7CCK, SCT, PNLIP
7trioleoylglycerol459.7APOC2, LPL, PNLIP
8ursodeoxycholic acid45 11 2411.7CCK, SCT, MLN, SLC10A2
9enterostatin459.6CLPS, CCK, GCG
10omeprazole45 29 50 11 2413.6CCK, SCT, MLN, SST
11c-peptide459.5GCG, CCK, SCT, SST
12intralipid459.5CCK, LPL, SST
13dtpa459.4SST, CCK, GCG
14caffeine45 50 29 2 11 2414.4CCK, LPL, SST, CFTR, ELANE
15bethanechol45 29 1111.4GCG, CCK, MLN, SST
16carbachol45 29 1111.3GCG, CCK, SCT, SST, CFTR
17norepinephrine45 11 2411.3CCK, LPL, CFTR, PNLIP, ELANE
18cisapride45 29 1111.3GCG, CCK, MLN
19tetrodotoxin45 60 2911.3GCG, CCK, SCT, MLN
20oxyntomodulin45 6010.2GCG, CCK, SCT, MLN, SST
21pirenzepine45 29 1111.1GCG, CCK, SST
22atropine45 29 1111.1GCG, CCK, SCT, MLN, SST
23thyroxine45 2410.1SCT, LPL, MLN, SST, ELANE
24oleic acid45 29 11 2412.1GCG, SCT, LPL, MTTP, PNLIP
25trypsinogen459.1ELANE, CCK, SCT, PRSS1, CFTR, PNLIP
26pge2459.0CCK, SCT, LPL, SST, CFTR, ELANE
27phosphatidylcholine459.0LPL, MTTP, CLPS, PNLIP, TMPRSS15
28ibmx45 29 6011.0GCG, CCK, SCT, LPL, SST, CFTR
29isoproterenol45 1110.0GCG, SCT, LPL, SST, CFTR, ELANE
30epinephrine45 11 2410.9GCG, SCT, LPL, SST, CFTR, ELANE
31orlistat45 60 1110.9GCG, CCK, LPL, CLPS, PNLIP
32taurocholate458.9CCK, SCT, LPL, CFTR, PNLIP, SLC10A2
33glycerol45 11 2410.9GCG, CCK, LPL, CFTR, PNLIP
34phospholipid458.8APOC2, SCT, LPL, MTTP, CLPS, PNLIP
35glutamine458.8GCG, CCK, SCT, LPL, CFTR, ELANE
36triacylglycerol458.6GCG, APOC2, LPL, MTTP, CLPS, PNLIP
375-hydroxytryptamine458.6GCG, CCK, MLN, SST, CFTR, PNLIP
38dopamine45 29 11 2411.6CFTR, SST, MLN, SCT, CCK, GCG
39cysteine458.5GCG, APOC2, SCT, MTTP, PRSS1, CFTR
40octreotide45 60 29 1111.5GCG, CCK, SCT, MLN, SST, PNLIP
41fatty acid458.4GCG, APOC2, LPL, MTTP, CLPS, PNLIP
42arginine458.3GCG, CCK, SCT, MLN, PRSS1, SST
43acetylcholine45 50 29 11 2412.2GCG, CCK, SCT, LPL, MLN, SST
44adenylate458.2GCG, CCK, SCT, LPL, MLN, SST
45glutamate458.2GCG, CCK, SCT, LPL, SST, CFTR
46heparin45 29 11 2411.1GCG, APOC2, LPL, MLN, PNLIP, TMPRSS15
47cholesterol45 29 11 2411.1CCK, APOC2, LPL, MLN, MTTP, CLPS
48lipid457.9GCG, APOC2, SCT, LPL, MTTP, CLPS
49glucose457.7GCG, CCK, APOC2, SCT, LPL, MLN
50serine457.6GCG, APOC2, SCT, MLN, PRSS1, CFTR

GO Terms for genes affiliated with Steatorrhea

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16Gene Ontology
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Cellular components related to Steatorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.7LPL, APOC2
2extracellular spaceGO:0056157.9GCG, CCK, APOC2, LPL, PRSS1, SST
3extracellular regionGO:0055765.2ELANE, GCG, CCK, APOC2, SCT, LPL

Biological processes related to Steatorrhea according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1chylomicron remodelingGO:0343719.9LPL, APOC2
2very-low-density lipoprotein particle remodelingGO:0343729.9LPL, APOC2
3lipid digestionGO:0442419.8PNLIP, CLPS
4triglyceride homeostasisGO:0703289.7LPL, APOC2
5lipoprotein metabolic processGO:0421579.7APOC2, LPL, MTTP
6lipoprotein transportGO:0429539.6MTTP, APOC2
7lipid catabolic processGO:0160429.3APOC2, CLPS, PNLIP
8retinoid metabolic processGO:0015239.2PNLIP, CLPS, LPL, APOC2
9phototransduction, visible lightGO:0076039.1APOC2, LPL, CLPS, PNLIP
10response to drugGO:0424939.1CFTR, SST, LPL, APOC2
11proteolysisGO:0065088.8PRSS1, TMPRSS15, CELA3B, CELA1, ELANE
12small molecule metabolic processGO:0442817.7GCG, APOC2, LPL, MTTP, PRSS1, GIF

Molecular functions related to Steatorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:0048069.6PNLIP, LPL
2apolipoprotein bindingGO:0341859.5MTTP, LPL
3hormone activityGO:0051798.7SST, MLN, SCT, CCK, GCG
4serine-type endopeptidase activityGO:0042528.7PRSS1, TMPRSS15, CELA3B, CELA1, ELANE

Products for genes affiliated with Steatorrhea

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Sources for Steatorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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