Steatorrhea disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: STT004	Steatorrhea malady MalaCards information score (MIFTS): 37
20 genes, 187 related diseases, clinical trials.

Summaries for Steatorrhea

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⁵⁹Wikipedia, ²⁹MalaCards
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Wikipedia:⁵⁹ Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may also float due to... more...

MalaCards: Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and cholesterol ester storage disease. An important gene associated with Steatorrhea is SLC10A2 (solute carrier family 10 (sodium/bile acid cotransporter family), member 2), and among its related pathways are Activation of proMMP8 and Digestion of dietary lipid. The compounds cerulein and loxiglumide have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Steatorrhea

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⁸Disease Ontology, ¹⁰DISEASES, ⁴¹Novoseek, ⁵⁶UMLS, ⁵²SNOMED-CT, ³⁶NCIt, ³¹MeSH
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Aliases & Descriptions:

steatorrhea ⁸ ¹⁰ ⁴¹ ⁵⁶

fatty stool ⁸

External Ids:

Disease Ontology⁸ DOID:10602

NCIt³⁶ C86917

SNOMED-CT⁵² 66187002

MeSH³¹ D045602

UMLS⁵⁶ C0038238

Related Diseases for Steatorrhea

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¹⁶GeneCards, ¹⁷GeneDecks
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Diseases related to steatorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 187)

id	Related Disease	Score	Top Affiliating Genes
1	pancreatic steatorrhea	30.9	PNLIP, CELA3B, CELA1
2	cholesterol ester storage disease	28.9	PNLIP
3	celiac disease	28.2	CCK
4	abetalipoproteinemia	26.7	MTTP, LPL
5	cystic fibrosis	23.7	PRSS1, PNLIP, SCT, LPL, ELANE, CELA3B
6	pancreatitis	23.4	LPL, SST, SCT, TMPRSS15, PNLIP, PRSS1
7	hyperparathyroidism	13.7	SCT
8	intestinal pseudo-obstruction	13.6	SST
9	intestinal obstruction	13.6	CFTR
10	cholangitis	13.5	CFTR
11	glossitis	13.5	GCG
12	cholangiocarcinoma	13.4	SCT, PNLIP
13	lipoprotein lipase deficiency	13.4	LPL
14	zollinger-ellison syndrome	13.4	SCT, SST
15	acromegaly	13.4	CCK, SST
16	familial lipoprotein lipase deficiency	13.3	LPL
17	somatostatinoma	13.3	SST
18	ileus	13.3	MLN
19	polycystic ovary syndrome	13.3	GCG
20	neuroendocrine tumor	13.3	GCG, SST
21	hyperinsulinemic hypoglycemia	13.3	SCT, SST
22	pseudomonas stutzeri infections	13.3	CFTR, ELANE
23	cholestasis	13.2	SLC10A2, GCG, CCK
24	cholelithiasis	13.2	CCK, SST
25	endocrine gland cancer	13.2	GCG, SST
26	alcoholism	13.1	SCT, CCK, CFTR
27	peptic ulcer	13.1	SCT, SST, CCK
28	gastrinoma	13.1	SCT, SST, GCG
29	duodenal ulcer	13.1	SCT, SST, CCK
30	short bowel syndrome	13.1	CCK, GCG, SST
31	irritable bowel syndrome	13.1	CCK, MLN
32	duodenogastric reflux	13.0	CCK, MLN
33	liver cirrhosis	13.0	MLN, SCT
34	vipoma	13.0	SST, SCT
35	familial hyperlipidemia	13.0	APOC2, LPL
36	familial hypertriglyceridemia	13.0	SLC10A2, LPL
37	glucagonoma	13.0	CCK, GCG, SST, SCT
38	morbid obesity	12.9	LPL, GCG, CCK
39	dyspepsia	12.9	MLN, CCK
40	pancreatic cancer	12.9	SCT, SST, GCG, CCK
41	carcinoid syndrome	12.9	CCK, GCG, SST, SCT
42	hyperlipoproteinemia type v	12.9	APOC2, LPL
43	gastroparesis	12.9	CCK, MLN, GCG
44	recurrent acute pancreatitis	12.9	SCT, LPL, CFTR
45	alcoholic pancreatitis	12.8	SCT, CCK, ELANE, CFTR
46	dumping syndrome	12.8	MLN, GCG, SST
47	cholera	12.8	SCT, GCG, CCK, CFTR
48	ischemia	12.8	MLN, GCG
49	autonomic neuropathy	12.8	GCG, MLN, CCK
50	constipation	12.7	CCK, MLN

Graphical network of the top 20 diseases related to steatorrhea:

Diseases related to steatorrhea

Symptoms for Steatorrhea

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Drugs & Therapeutics for Steatorrhea

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Sources:
⁵CenterWatch, ³⁸NIH Clinical Center, ⁶ClinicalTrials, ⁵⁶UMLS, ³⁷NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for steatorrhea

Search NIH Clinical Center for steatorrhea

Search CenterWatch for steatorrhea

Genetic Tests for Steatorrhea

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Anatomical Context for Steatorrhea

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Animal Models for Steatorrhea or affiliated genes

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³³MGI, ²⁶inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to steatorrhea:

³³

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	6.9	CLPS, PNLIP, TMPRSS15, SCT, SST, LPL

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions.

Publications for Steatorrhea

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⁴⁷PubMed
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Articles related to steatorrhea:

id	Title	Authors	Year	Affiliating Genes
1	Lipoprotein Lipase Mutation S447X Associated With Pancreatic Calcification and Steatorrhea in Hyperlipidemic Pancreatitis. (19034041)	Chang Y.T.... Wong J.M.	2008	LPL, APOC2
2	Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. (16954337)	Knop F.K.... Krarup T.	2007	GCG
3	Bone mineral density in patients with pancreatic insufficiency and steatorrhea. (9149203)	MorA!n C.E.... Bai J.C.	1997	SCT
4	Octreotide decreases biliary and pancreatic exocrine function, and induces steatorrhea in healthy subjects. (7827373)	Nakamura T.... Machida K.	1994	PNLIP

Genes related to Steatorrhea

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¹⁶GeneCards, ⁴²Novus Biologicals, ²⁶inGenious Targeting Laboratory
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Genes related to steatorrhea:

id	Symbol	Products	Description	Score	Context
1	SLC10A2		solute carrier family 10 (sodium/bile acid cotransporter family), member 2	20.50
2	SCT		secretin	19.50	Publications
3	MTTP		microsomal triglyceride transfer protein	18.50
4	CCK		cholecystokinin	17.50
5	TMPRSS15		transmembrane protease, serine 15	16.50
6	ELANE		elastase, neutrophil expressed	15.50
7	SST		somatostatin	14.50
8	CFTR		cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	13.50
9	COX4I2		cytochrome c oxidase subunit IV isoform 2 (lung)	12.47
10	GIF		gastric intrinsic factor (vitamin B synthesis)	11.47
11	APOC2		apolipoprotein C-II	10.47	Publications
12	CLPS		colipase, pancreatic	9.47
13	PRSS1		protease, serine, 1 (trypsin 1)	8.47
14	LPL		lipoprotein lipase	7.47	Publications
15	PNLIP		pancreatic lipase	6.51	Publications
16	GCG		glucagon	5.51	Publications
17	CELA1		chymotrypsin-like elastase family, member 1	4.50
18	CELA3B		chymotrypsin-like elastase family, member 3B	3.50
19	ABHD6		abhydrolase domain containing 6	2.50
20	MLN		motilin	1.47

Products for genes related to steatorrhea disease:

id	Company	Proteins	Lysates	Antibodies	Knockout Mice
1	Novus Biologicals	20	20	20	-
2	inGenious Targeting Laboratory	-	-	-

Variations for Steatorrhea

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Expression for genes affiliated with Steatorrhea

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Steatorrhea

Pathways for genes affiliated with Steatorrhea

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⁵⁰Reactome, ⁴⁶PharmGKB, ³⁴NCBI BioSystems Database, ¹²EMD Millipore, ²⁷KEGG
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Pathways related to steatorrhea according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Activation of proMMP8⁵⁰	9.9	PRSS1, ELANE
2	Digestion of dietary lipid⁵⁰	9.7	CLPS, PNLIP
3	Statin Pathway, Pharmacodynamics⁴⁶ Hide members Statin Pathway³⁴	9.6	APOC2, MTTP, LPL
4	Selected targets of CREB1¹²	9.6	CFTR, CCK, GCG
5	triacylglycerol degradation³⁴	9.2	ABHD6, PNLIP
6	Retinoid metabolism and transport⁵⁰ Hide members Diseases associated with visual transduction⁵⁰ Visual phototransduction⁵⁰	9.1	PNLIP, LPL, APOC2, CLPS
7	Lipoprotein metabolism⁵⁰ Hide members Lipid digestion, mobilization, and transport⁵⁰ HDL-mediated lipid transport⁵⁰ Chylomicron-mediated lipid transport⁵⁰	8.9	CLPS, APOC2, MTTP, LPL, PNLIP
8	Pancreatic secretion²⁷	8.8	PRSS1, PNLIP, CELA3B, CFTR
9	Class A/1 (Rhodopsin-like receptors)⁵⁰ Hide members GPCR ligand binding⁵⁰ Peptide ligand-binding receptors⁵⁰ G alpha (i) signalling events⁵⁰ Neuroactive ligand-receptor interaction²⁷	8.5	PRSS1, SCT, SST, GCG, MLN, CCK
10	Metabolism⁵⁰ Hide members Metabolism of lipids and lipoproteins⁵⁰ Metabolic pathways²⁷	8.0	PNLIP, LPL, GCG, MTTP, APOC2, COX4I2
11	Signaling by GPCR⁵⁰ Hide members Signal Transduction⁵⁰ GPCR downstream signaling⁵⁰	7.4	PNLIP, SCT, SST, LPL, GCG, MLN

Compounds for genes affiliated with Steatorrhea

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⁴¹Novoseek, ⁵⁵Tocris Bioscience, ¹¹DrugBank, ²²HMDB, ⁴⁶PharmGKB, ²BitterDB
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Compounds related to steatorrhea according to GeneCards/GeneDecks:

(show top 50) (show all 99)

id	Compound	Score	Top Affiliating Genes
1	cerulein⁴¹	10.2	ELANE, CCK, SCT
2	loxiglumide⁴¹	10.2	SST, CCK, SCT
3	taurodeoxycholate⁴¹	10.0	SST, CCK, CLPS, SCT
4	caerulein⁴¹	9.9	CCK, MLN, SCT
5	lafutidine⁴¹	9.9	MLN, SCT, SST
6	enterostatin⁴¹ ⁵⁵	10.8	GCG, CCK, CLPS
7	trioleoylglycerol⁴¹	9.8	LPL, PNLIP, APOC2
8	pirenzepine⁴¹ ¹¹	10.8	CCK, SST, GCG
9	ursodeoxycholic acid⁴¹ ¹¹ ²²	11.7	SCT, CCK, MLN, SLC10A2
10	intralipid⁴¹	9.7	LPL, SST, CCK
11	omeprazole⁴¹ ⁵⁵ ⁴⁶ ¹¹ ²²	13.7	SST, CCK, MLN, SCT
12	c-peptide⁴¹	9.7	CCK, SCT, SST, GCG
13	cysteine⁴¹	9.6	SCT, ELANE, APOC2, PRSS1
14	bicarbonate⁴¹	9.6	CFTR, PNLIP, SCT, CCK
15	caffeine⁴¹ ⁴⁶ ² ¹¹ ²²	13.5	ELANE, CFTR, CCK, LPL, SST
16	bethanechol⁴¹ ¹¹	10.5	MLN, SST, GCG, CCK
17	carbachol⁴¹ ¹¹	10.5	CFTR, SCT, SST, GCG, CCK
18	cisapride⁴¹ ⁵⁵ ¹¹	11.5	CCK, MLN, GCG
19	tetrodotoxin⁴¹	9.4	SCT, CCK, MLN, GCG
20	oxyntomodulin⁴¹ ⁵⁵	10.3	GCG, SCT, SST, CCK, MLN
21	atropine⁴¹ ¹¹	10.3	MLN, CCK, GCG, SST, SCT
22	dtpa⁴¹	9.3	SST, CCK, GCG
23	oleic acid⁴¹ ¹¹ ²²	11.3	PNLIP, MTTP, GCG, LPL, SCT
24	thyroxine⁴¹ ²²	10.2	MLN, LPL, ELANE, SST, SCT
25	phosphatidylcholine⁴¹	9.2	MTTP, LPL, TMPRSS15, PNLIP, CLPS
26	ibmx⁴¹	9.2	CCK, SCT, SST, GCG, LPL, CFTR
27	orlistat⁴¹ ⁵⁵ ¹¹	11.1	GCG, CLPS, PNLIP, LPL, CCK
28	isoproterenol⁴¹ ¹¹	10.1	SST, LPL, GCG, ELANE, CFTR, SCT
29	epinephrine⁴¹ ¹¹ ²²	11.1	SCT, SST, CFTR, GCG, LPL, ELANE
30	octreotide⁴¹ ⁵⁵ ¹¹	11.1	ELANE, CCK, PNLIP, MLN, GCG
31	pge2⁴¹	9.1	CCK, SCT, CFTR, ELANE, LPL, SST
32	taurocholate⁴¹	9.1	SLC10A2, PNLIP, LPL, CFTR, CCK, TMPRSS15
33	trypsinogen⁴¹	9.1	PRSS1, PNLIP, TMPRSS15, SCT, CCK, ELANE
34	glycerol⁴¹ ¹¹ ²²	11.0	CFTR, PNLIP, LPL, GCG, CCK
35	phospholipid⁴¹	9.0	LPL, PNLIP, CLPS, SCT, MTTP, APOC2
36	glutamine⁴¹	8.9	ELANE, LPL, CFTR, SCT, GCG, CCK
37	triacylglycerol⁴¹	8.8	APOC2, LPL, CLPS, PNLIP, MTTP, GCG
38	heparin⁴¹ ¹¹ ²²	10.8	ELANE, PNLIP, TMPRSS15, APOC2, LPL, GCG
39	5-hydroxytryptamine⁴¹	8.8	CFTR, CCK, GCG, SST, PNLIP, MLN
40	norepinephrine⁴¹ ¹¹ ²²	10.5	GCG, CCK, ELANE, LPL, SST, PNLIP
41	dopamine⁴¹ ¹¹ ²²	10.5	CCK, SCT, CFTR, SST, MLN, GCG
42	glutamate⁴¹	8.4	ELANE, CCK, GCG, LPL, SST, SCT
43	acetylcholine⁴¹ ¹¹ ²²	10.4	CFTR, ELANE, SCT, CCK, MLN, GCG
44	fatty acid⁴¹	8.4	LPL, CLPS, APOC2, MTTP, PNLIP, GCG
45	adenylate⁴¹	8.4	CFTR, ELANE, CCK, MLN, GCG, SCT
46	cholesterol⁴¹ ¹¹ ²²	10.4	SLC10A2, PNLIP, LPL, MLN, MTTP, APOC2
47	arginine⁴¹	8.3	MLN, CCK, GCG, SST, SCT, TMPRSS15
48	lipid⁴¹	8.1	CLPS, GCG, LPL, MTTP, SLC10A2, PNLIP
49	glucose⁴¹	8.0	SCT, MLN, APOC2, SST, LPL, GCG
50	serine⁴¹	7.7	PNLIP, ELANE, APOC2, TMPRSS15, GCG, SCT

GO Terms for genes affiliated with Steatorrhea

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¹⁵Gene Ontology
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Cellular components related to steatorrhea according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chylomicron	GO:042627	9.8	APOC2, LPL
2	extracellular space	GO:005615	8.0	PRSS1, SST, GIF, LPL, GCG, APOC2
3	extracellular region	GO:005576	5.6	CLPS, PRSS1, PNLIP, SCT, SST, LPL

Biological processes related to steatorrhea according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chylomicron remodeling	GO:034371	10.0	APOC2, LPL
2	very-low-density lipoprotein particle remodeling	GO:034372	9.9	APOC2, LPL
3	lipid digestion	GO:044241	9.9	CLPS, PNLIP
4	lipoprotein metabolic process	GO:042157	9.7	LPL, MTTP, APOC2
5	retinoid metabolic process	GO:001523	9.7	CLPS, PNLIP
6	lipid catabolic process	GO:016042	9.3	CLPS, APOC2, PNLIP
7	lipid metabolic process	GO:006629	9.1	CLPS, APOC2, MTTP, LPL, PNLIP
8	proteolysis	GO:006508	8.5	PRSS1, TMPRSS15, ELANE, CELA3B, CELA1
9	small molecule metabolic process	GO:044281	7.9	SLC10A2, PNLIP, LPL, GCG, MTTP, APOC2

Molecular functions related to steatorrhea according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	apolipoprotein binding	GO:034185	9.9	MTTP, LPL
2	hormone activity	GO:005179	8.8	CCK, MLN, GCG, SST, SCT
3	serine-type endopeptidase activity	GO:004252	8.2	PRSS1, TMPRSS15, ELANE, CELA3B, CELA1

Products for genes affiliated with Steatorrhea

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Antibodies
Proteins
Lysates

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions

Sources for Steatorrhea

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¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Ontology

¹⁶GeneCards

¹⁷GeneDecks

¹⁸GeneReviews

¹⁹GeneTests

²⁰Genetics Home Reference

²¹HGMD

²²HMDB

²³ICD10

²⁴ICD10 via Orphanet

²⁵ICD9CM

²⁶inGenious Targeting Laboratory

²⁷KEGG

²⁸LifeMap Discovery™

²⁹MalaCards

³⁰MedlinePlus

³¹MeSH

³²MESH via Orphanet

³³MGI

³⁴NCBI BioSystems Database

³⁵NCBI Bookshelf

³⁶NCIt

³⁷NDF-RT

³⁸NIH Clinical Center

³⁹NIH Rare Diseases

⁴⁰NINDS

⁴¹Novoseek

⁴²Novus Biologicals

⁴³OMIM

⁴⁴OMIM via Orphanet

⁴⁵Orphanet

⁴⁶PharmGKB

⁴⁷PubMed

⁴⁸QIAGEN

⁴⁹R&D Systems

⁵⁰Reactome

⁵¹SABiosciences

⁵²SNOMED-CT

⁵³SNOMED-CT via Orphanet

⁵⁴Thomson Reuters

⁵⁵Tocris Bioscience

⁵⁶UMLS

⁵⁷UMLS via Orphanet

⁵⁸UniProtKB/Swiss-Prot

⁵⁹Wikipedia

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