Stenotrophomonas Maltophilia malady

Summaries for Stenotrophomonas Maltophilia

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Stenotrophomonas maltophilia (s. maltophilia) is a type of bacterium that is found in various natural environments (such as soil, water and plants), but also occurs in the hospital environment and may cause infections including those that affect the bloodstream, respiratory tract, urinary tract and surgical-sites. infections are uncommon and typically only occur in individuals with severely impaired immune systems. risk factors in hospitalized individuals may include prior exposure to antimicrobials, mechanical ventilation, and prolonged hospitalization. it typically grows and spreads through medical devices, hospital fluids (such as irrigation solutions or iv fluids) or patient secretions, but does not readily spread between patients. s. maltophilia does not respond to many antibiotics but most strains are susceptible to co-trimoxazole treatment. last updated: 3/2/2012

MalaCards: Stenotrophomonas Maltophilia, also known as stenotrophomonas maltophilia bacteremia, is related to cystic fibrosis and pneumonia. An important gene associated with Stenotrophomonas Maltophilia is BPI (bactericidal/permeability-increasing protein), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and ATF-2 transcription factor network. The compounds hydrocortisone and ivig have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and tumorigenesis.

Wikipedia:63 Stenotrophomonas maltophilia is an aerobic, nonfermentative, Gram-negative bacterium. It is an uncommon... more...

Aliases & Classifications for Stenotrophomonas Maltophilia

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

stenotrophomonas maltophilia 42
stenotrophomonas maltophilia bacteremia 42 60

Related Diseases for Stenotrophomonas Maltophilia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Stenotrophomonas Maltophilia:

Diseases related to stenotrophomonas maltophilia

Clinical Features for Stenotrophomonas Maltophilia

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Drugs & Therapeutics for Stenotrophomonas Maltophilia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Stenotrophomonas Maltophilia

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Anatomical Context for Stenotrophomonas Maltophilia

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Animal Models for Stenotrophomonas Maltophilia or affiliated genes

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MGI Mouse Phenotypes related to Stenotrophomonas Maltophilia:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0IL6, IL10, TNF, IFNG, CCL3
2MP:00020067.8IFNG, TNF, IL10, IL1B, IL6
3MP:00053876.9IL6, CCL17, CCL3, IFNG, TNF, IL10

Publications for Stenotrophomonas Maltophilia

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Genetic Variations for Stenotrophomonas Maltophilia

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Expression for genes affiliated with Stenotrophomonas Maltophilia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stenotrophomonas Maltophilia

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Pathways for genes affiliated with Stenotrophomonas Maltophilia

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 12EMD Millipore
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Pathways related to Stenotrophomonas Maltophilia according to GeneCards/GeneDecks:

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idSuper pathways (with members indented)ScoreTop Affiliating Genes
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Transcription Role of VDR in regulation of genes involved in osteoporosis
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109.5TNF, IL10
119.2IL1B, IL8, IL6
129.2IFNG, IL6, IL8
139.2IL6, IL10, IFNG
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169.0IL1B, TNF, IFNG
179.0IL1B, IFNG, TNF
188.9IL6, IL1B, TNF
198.9IL1B, TNF, CCL3
208.9IL6, TNF, IFNG
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8.8CXCL2, CCL17, CCL3
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8.8CCL17, CCL3, CXCL2
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8.8CXCL2, CCL3, CCL17
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8.6IL1B, TNF, IL6, IL8
258.6IL6, IL1B, IL10, TNF
268.6IL6, IFNG, TNF, IL8
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8.6IFNG, IL10, CCL3, TNF
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8.5CCL3, CCL17, CXCL2, IL8
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8.5CCL17, CXCL2, CCL3, IL8
308.5IL8, CXCL2, CCL3, CCL17
318.5IFNG, IL1B, IL6, TNF
328.3TNF, CXCL2, IL1B, IL8
338.3IL6, IL1B, IL8, IL10, TNF
348.3TNF, IL10, IL8, IL1B, IL6
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8.2IL1B, IL8, TNF, IL6, IFNG
Immune response Bacterial infections in normal airways
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8.2IL6, IL1B, TNF, IL8, IFNG
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8.2IL6, IFNG, IL1B, IL8, TNF
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8.1IL6, IL1B, IL10, TNF, IFNG
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8.1IL1B, IL10, IL6, TNF, IFNG
Development PDGF signaling via STATs and NF-kB
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8.1IL1B, IFNG, TNF, IL10, IL6
418.1IFNG, IL1B, IL10, TNF, IL6
428.1TNF, CXCL2, IL6, IL1B
438.1CXCL2, TNF, IL6, IL1B
447.8IFNG, TNF, IL10, IL8, IL1B, IL6
457.8IL8, IL10, TNF, IFNG, IL6, IL1B
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7.8IL6, IL1B, IL8, CXCL2, TNF
477.8TNF, IL1B, IL6, IL8, CXCL2
487.4IL1B, IL8, CXCL2, IFNG, IL6, CCL3
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7.3IL8, IL6, IL1B, IL10, CCL3, IFNG
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6.6IL10, CCL17, IL6, CXCL2, IL8, TNF

Compounds for genes affiliated with Stenotrophomonas Maltophilia

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44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Stenotrophomonas Maltophilia according to GeneCards/GeneDecks:

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idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.6IL8
4endotoxin449.8BPI, CXCL2
5pdtc449.6IL8, IL1B, IL6
6gm-csf44 2810.5TNF, IFNG, IL10
7anaphylatoxin449.5IL8, IL1B
8cyclosporin a44 28 5911.4IFNG, CCL17, CCL3
9dexamethasone44 49 28 1112.2CXCL2, IL6, CCL17
10mcp 1449.1IL6, IL8, IL10, CCL3
115 aminosalicylic acid449.0TNF, IL8, IL10, IL1B
12gold sodium thiomalate448.9IL1B, IL8, TNF, IFNG
13staurosporin448.8TNF, IL1B, IL8, IFNG
14vesnarinone448.8IL1B, IFNG, IL6, TNF
15adalimumab44 49 1110.7IL10, TNF, IL6, IFNG
16toxin-1448.7CCL3, TNF, IL1B, IL10, IL8
17tpck448.7TNF, IL8, IL1B, IL6
18imiquimod44 28 59 1111.6TNF, IL10, IL6, IL8, IFNG
19taurine chloramine448.6TNF, IL8, IL1B, IL6, IFNG
208-isoprostane448.5CCL3, TNF, IL10, IL8, IL6
21okt3448.5IFNG, TNF, IL10, IL6
22infliximab44 49 1110.4IL1B, IFNG, TNF, IL10, IL6
23thalidomide44 49 59 1111.3IL6, IL1B, IL10, TNF, IFNG
24il-12448.3TNF, IFNG, IL10, IL8, IL1B, IL6
25etanercept44 49 1110.3IL6, IL8, IL10, TNF, IFNG, IL1B
2615-deoxy-delta-12,14-prostaglandin j2448.2IL6, IL8, IL10, TNF, IFNG, IL1B
27mip 1alpha448.2IL8, IL1B, IL6, IL10, CCL3, TNF
28peptidoglycan44 289.2CCL3, TNF, IL10, IL8, IL1B, IL6
29leukotriene b444 59 2410.1IL8, TNF, CCL3, IL1B, IL6
30triptolide448.1IFNG, IL6, IL1B, TNF, CCL3, IL8
31simvastatin44 49 59 28 11 2413.1IL10, TNF, IFNG, CCL3, IL8, IL6
32poly(i-c)448.0IFNG, CCL3, IL6, IL1B, IL8, TNF
33polymyxin b448.0BPI, IFNG, TNF, IL10, IL8, IL1B
34lipoteichoic acid447.9BPI, CCL3, TNF, IL10, IL8, IL1B
35polyinosinic-polycytidylic acid447.8IL1B, IL6, CCL3, TNF, IL8, IL10
36neopterin447.7CCL3, TNF, IFNG, IL10, IL8, IL1B
37actinomycin d447.7CCL3, TNF, IL6, IL1B, IL8, BPI
38histamine44 28 249.7IL8, IL6, IL1B, TNF, IL10, IFNG
39sp 60012544 598.6IL6, IL1B, IL8, CXCL2, CCL3, TNF
40rantes447.5IL6, IL1B, CXCL2, TNF, CCL3, IFNG
41tarc447.5IL8, CCL17, CCL3, IFNG, TNF, CXCL2
42il 10447.4CCL3, CCL17, IFNG, TNF, IL10, IL8
43groalpha447.4IL6, CCL3, TNF, CXCL2, IL10, IL8
44ly294002447.3CXCL2, IL10, TNF, IL8, IL1B, IL6
45pd 98,059447.3IL6, CCL3, IL1B, IL8, CXCL2, TNF
46lactate447.3IL6, CXCL2, IL8, TNF, BPI, DHFR
47sb 20358044 597.9TNF, IL1B, IL6, IL8, CCL3, IFNG
48ccl344 287.6CCL3, IFNG, TNF, CXCL2, IL10, IL8
49vegf446.6IFNG, IL1B, IL8, IL10, CXCL2, TNF
50nitric oxide44 11 248.3IL1B, IL6, IL10, IFNG, IL8, CXCL2

GO Terms for genes affiliated with Stenotrophomonas Maltophilia

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16Gene Ontology
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Cellular components related to Stenotrophomonas Maltophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9IL6, TNF, IFNG
2extracellular spaceGO:0056156.1IL6, CCL17, CCL3, IFNG, TNF, CXCL2
3extracellular regionGO:0055765.9BPI, CCL17, CCL3, IFNG, TNF, CXCL2

Biological processes related to Stenotrophomonas Maltophilia according to GeneCards/GeneDecks:

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idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.5IL10
2positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IFNG
3receptor biosynthetic processGO:0328009.9TNF, IL10
4positive regulation of interleukin-6 biosynthetic processGO:0454109.9IFNG, IL1B
5neutrophil apoptotic processGO:0017819.9IFNG, IL6
6sequestering of triglycerideGO:0307309.8TNF, IL1B
7positive regulation of heterotypic cell-cell adhesionGO:0341169.8IL1B, TNF
8positive regulation of fever generationGO:0316229.8TNF, IL1B
9positive regulation of vitamin D biosynthetic processGO:0605579.8TNF, IFNG
10cellular response to lipopolysaccharideGO:0712229.7IL8, IL10, IFNG
11regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7IL1B, TNF
12negative regulation of interleukin-6 productionGO:0327159.7TNF, BPI, IL10
13epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.6TNF, IL6
14cell activationGO:0017759.6CCL3, TNF
15embryonic digestive tract developmentGO:0485669.6TNF, IL8
16defense response to bacteriumGO:0427429.6IL10, IFNG, BPI
17negative regulation of lipid storageGO:0108889.6IL6, TNF
18negative regulation of lipid catabolic processGO:0509959.6TNF, IL1B
19negative regulation of growth of symbiont in hostGO:0441309.5TNF, IL10, IFNG
20defense response to protozoanGO:0428329.5IFNG, IL6
21positive regulation of T cell proliferationGO:0421029.5IL1B, IL6, IFNG
22response to molecule of bacterial originGO:0022379.5IL10, IL8, CXCL2
23positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4TNF, IFNG, IL1B
24calcium-mediated signalingGO:0197229.4IL8, TNF, CCL3
25positive regulation of chemokine biosynthetic processGO:0450809.4IFNG, TNF, IL1B
26positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IFNG, IL1B
27positive regulation of osteoclast differentiationGO:0456729.4TNF, IFNG
28response to glucocorticoid stimulusGO:0513849.4IL10, IL6, TNF
29lipopolysaccharide-mediated signaling pathwayGO:0316639.3CCL3, TNF, IL1B
30cellular response to organic cyclic compoundGO:0714079.3TNF, CCL3, IL1B
31protein kinase B signaling cascadeGO:0434919.3IL1B, CCL3, TNF
32positive regulation of interleukin-6 productionGO:0327559.3IL1B, TNF, IL6
33regulation of insulin secretionGO:0507969.3IFNG, TNF, IL1B
34MAPK cascadeGO:0001659.3IL1B, TNF, CCL3
35humoral immune responseGO:0069599.3TNF, IFNG, IL6
36cell-cell signalingGO:0072679.3CCL17, CCL3, IL10, IL1B
37positive regulation of chemokine productionGO:0327229.2TNF, IL6
38neutrophil chemotaxisGO:0305939.2IFNG, IL8, CCL3, IL1B
39positive regulation of protein kinase B signaling cascadeGO:0518979.2TNF, IL6, CCL3
40monocyte chemotaxisGO:0025489.1IL6, CCL3
41positive regulation of NF-kappaB transcription factor activityGO:0510929.1TNF, IL1B, IL6
42positive regulation of ERK1 and ERK2 cascadeGO:0703749.1CCL3, TNF, IL6
43positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0IL6, TNF, IL10, IL1B
44chemotaxisGO:0069358.9CCL3, CCL17, CXCL2
45positive regulation of nitric oxide biosynthetic processGO:0454298.9IL1B, TNF, IFNG, IL6
46response to drugGO:0424938.9TNF, IFNG, IL10, IL6
47negative regulation of cell proliferationGO:0082858.8IL8, IL6, TNF, IL1B
48immune responseGO:0069558.7IL1B, CXCL2, CCL17, BPI, IL8
49positive regulation of transcription from RNA polymerase II promoterGO:0459448.5IFNG, TNF, IL10, IL6, IL1B
50inflammatory responseGO:0069547.1IL8, CCL17, CCL3, TNF, CXCL2, IL10

Molecular functions related to Stenotrophomonas Maltophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080098.2IL8, CXCL2, CCL3, CCL17
2cytokine activityGO:0051258.1IL6, IL1B, IL10, TNF, IFNG

Products for genes affiliated with Stenotrophomonas Maltophilia

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Sources for Stenotrophomonas Maltophilia

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26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
61UMLS via Orphanet