MCID: STR029
MIFTS: 27

Sternal Cleft malady

Rare diseases, Respiratory diseases categories
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Summaries for Sternal Cleft

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Sternal clefts are rare congenital malformations that result from defective embryologic fusion of paired... more...

MalaCards: Sternal Cleft, also known as congenital sternal cleft, is related to phace syndrome and congenital heart disease, and has symptoms including anomalies of eyes and visionand anomalies of the neck. Affiliated tissues include eye, bone and heart.

Aliases & Classifications for Sternal Cleft

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Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

49
sternal cleft:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

sternal cleft 43 49 62
congenital sternal cleft 43
sternum bifidum 49
cleft sternum 49


External Ids:

MESH via Orphanet36 C537489
ICD10 via Orphanet26 Q76.7
SNOMED-CT via Orphanet59 54008006
UMLS via Orphanet63 C0265696, C2931507

Related Diseases for Sternal Cleft

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sternal Cleft via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1phace syndrome10.3
2congenital heart disease10.3
3hemangioma10.3
4poland syndrome10.1
5tetralogy of fallot10.1
6gastroschisis10.1
7patent ductus arteriosus10.1
8cervicitis10.1
9periostitis10.1
10asternia10.1
11transposition of the great arteries10.1
12aneurysm10.1

Graphical network of diseases related to Sternal Cleft:



Diseases related to sternal cleft

Symptoms for Sternal Cleft

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49Orphanet
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Symptoms:

49
  • anomalies of eyes and vision
  • anomalies of the neck

Drugs & Therapeutics for Sternal Cleft

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Sternal Cleft

Search NIH Clinical Center for Sternal Cleft

Genetic Tests for Sternal Cleft

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Anatomical Context for Sternal Cleft

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33MalaCards
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MalaCards organs/tissues related to Sternal Cleft:

33
Eye, Bone, Heart, Skin, Liver

Animal Models for Sternal Cleft or affiliated genes

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Publications for Sternal Cleft

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52PubMed
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Articles related to Sternal Cleft:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Congenital Sternal Cleft along with Persistent Left-Sided Superior Vena Cava: A Rare Presentation. (23841006)
2013
2
Primary repair of sternal cleft in infancy using combined periosteal flap and sliding osteochondroplasty. (23427313)
2013
3
Incidental detection of superior sternal cleft on Technetium-99m methylene diphosphonate bone scan. (24163521)
2013
4
Congenital sternal cleft. (23164014)
2012
5
Accidental finding on bone scan: isolated upper sternal cleft in an adult. (22228364)
2012
6
Combined repair of upper sternal cleft and transposition of the great arteries in a newborn. (23098954)
2012
7
Phenotypic spectrum and management of sternal cleft: literature review and presentation of a new series. (21737294)
2012
8
Sternal cleft: prenatal multimodality imaging. (22307410)
2012
9
Sternal cleft in a neonate- repaired with silastic block and pectoralis major flaps. (21340727)
2011
10
Primary repair of complete sternal cleft in an adult: a 4-year follow-up. (21841884)
2011
11
Complete sternal cleft in an adult: case report. (21850590)
2011
12
Superior sternal cleft, supraumbilical midline raphe and haemangiomas in a baby girl with an ostium secundum ASD. (21233709)
2011
13
E-page original images. A rare case of isolated complete congenital sternal cleft. (21062690)
2010
14
Sternal cleft repair: a report of two cases and review of literature. (20859036)
2010
15
Case report. Isolated complete congenital sternal cleft in an adult: MDCT imaging findings. (19759206)
2009
16
Autologous repair of isolated complete sternal cleft in an adolescent. (20006040)
2009
17
Prenatal diagnosis of a complete sternal cleft in a child with PHACES syndrome-a case report. (19142902)
2009
18
Low cervical skin crease approach for superior sternal cleft repair. (19735841)
2009
19
Isolated superior sternal cleft. (19130978)
2009
20
Congenital medium sternal cleft with partial ectopia cordis repair. (21918661)
2009
21
Sternal cleft, a rare congenital anomaly. Report of the first Tunisian case. (19213519)
2008
22
Thymectomy to achieve primary closure of total sternal cleft. (19040914)
2008
23
Sternal cleft associated with enterogenous cyst treated during the newborn period. (17806026)
2007
24
Congenital sternal cleft in an adult male not associated with cardiac defects or ectopia cordis. (17462433)
2007
25
Sternal cleft--a natural absurdity or a surgical opportunity. (17336207)
2007
26
Superior sternal cleft, cutaneous, and airway haemangiomas. (17185427)
2007
27
Surgical repair of congenital sternal cleft in an adult to prevent traumatic pericardial rupture. (17151973)
2006
28
Surgical repair of combined gastroschisis and sternal cleft. (15991160)
2005
29
Superior sternal cleft associated with PHACES syndrome: postnatal sonographic findings. (12636335)
2003
30
Superior sternal cleft and minor hemangiomas in a newborn. (14577681)
2003
31
Sternal cleft: a surgical opportunity. (12596098)
2003
32
Primary repair of a sternal cleft in an infant with autogenous tissues. (17670117)
2003
33
Congenital sternal cleft with patent ductus arteriosus: report of a case. (11871821)
2002
34
Complete congenital sternal cleft associated with pectus excavatum. (12224725)
2002
35
Superior congenital sternal cleft. (11536030)
2001
36
Congenital sternal cleft. (11254425)
2001
37
Upper sternal cleft associated with unusual symptoms. (11145410)
2000
38
Repair of congenital sternal cleft in infants and adolescents. (9800797)
1998
39
Superior sternal cleft: construction with a titanium plate. (9427932)
1998
40
Combined repair of upper sternal cleft and tetralogy of Fallot in an infant. (9262621)
1997
41
Neonatal sternal cleft associated with an extrathoracic cystic mass. (9126771)
1997
42
Primary repair of complete sternal cleft with pectoralis major muscle flaps. (8619730)
1996
43
Congenital skin fistula with sternal cleft. (7718480)
1995
44
Successful repair of complete sternal cleft associated with congenital heart disease. Report of one case. (7721929)
1995
45
Sternal cleft: case report and review of a series of nine patients. (8588577)
1995
46
Sternal cleft associated with vascular anomalies and micrognathia. (8328853)
1993
47
Complete sternal cleft. (2609075)
1989
48
Aneurysm of the ascending aorta associated with sternal cleft, cutaneous hemangioma, and occlusion of the right innominate artery in a neonate. (3541557)
1987
49
A supraumbilical midline raphAc with sternal cleft in a 47,XXX woman. (3605199)
1987
50
Congenital upper sternal cleft: a case with successful surgical repair. (5419075)
1970

Variations for Sternal Cleft

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Expression for genes affiliated with Sternal Cleft

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Sources:
15Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Sternal Cleft.

Pathways for genes affiliated with Sternal Cleft

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Compounds for genes affiliated with Sternal Cleft

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GO Terms for genes affiliated with Sternal Cleft

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Products for genes affiliated with Sternal Cleft

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sternal Cleft

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet