MCID: STR029
MIFTS: 21

Sternal Cleft malady

Respiratory category

Summaries for Sternal Cleft

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Sternal clefts are rare congenital malformations that result from defective embryologic fusion of paired... more...

MalaCards: Sternal Cleft, also known as congenital sternal cleft, is related to phace syndrome and asternia, and has symptoms including anomalies of eyes and visionand anomalies of the neck. Affiliated tissues include heart, liver and skin.

Aliases & Classifications for Sternal Cleft

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Characteristics (Orphanet epidemiological data):

49
sternal cleft:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

sternal cleft 43 49 61
congenital sternal cleft 43
sternum bifidum 49
cleft sternum 49


External Ids:

MESH via Orphanet36 C537489
ICD10 via Orphanet26 Q76.7
SNOMED-CT via Orphanet58 54008006
UMLS via Orphanet62 C0265696, C2931507

Related Diseases for Sternal Cleft

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sternal Cleft via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1phace syndrome10.3
2asternia10.1
3aortic coarctation10.1

Clinical Features for Sternal Cleft

Sources:
49Orphanet
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Symptoms:

49
  • anomalies of eyes and vision
  • anomalies of the neck

Drugs & Therapeutics for Sternal Cleft

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Sternal Cleft

Search CenterWatch for Sternal Cleft

Genetic Tests for Sternal Cleft

Anatomical Context for Sternal Cleft

Sources:
33MalaCards
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MalaCards organs/tissues related to Sternal Cleft:

33
Heart, Liver, Skin

Animal Models for Sternal Cleft or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sternal Cleft

Sources:
51PubMed
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Articles related to Sternal Cleft:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Congenital Sternal Cleft along with Persistent Left-Sided Superior Vena Cava: A Rare Presentation. (23841006)
2013
2
Primary repair of sternal cleft in infancy using combined periosteal flap and sliding osteochondroplasty. (23427313)
2013
3
Incidental detection of superior sternal cleft on Technetium-99m methylene diphosphonate bone scan. (24163521)
2013
4
Congenital sternal cleft. (23164014)
2012
5
Combined repair of upper sternal cleft and transposition of the great arteries in a newborn. (23098954)
2012
6
Sternal cleft: prenatal multimodality imaging. (22307410)
2012
7
Titanium plates for primary closure of complete sternal cleft in an adult: five-year follow-up. (22329985)
2012
8
Reconstruction of sternal cleft and aplasia cutis with a Medpor and a rectus abdominis musculocutaneous flap. (22337399)
2012
9
Sternal cleft in a neonate- repaired with silastic block and pectoralis major flaps. (21340727)
2011
10
Complete sternal cleft in an adult: case report. (21850590)
2011
11
Superior sternal cleft, supraumbilical midline raphe and haemangiomas in a baby girl with an ostium secundum ASD. (21233709)
2011
12
E-page original images. A rare case of isolated complete congenital sternal cleft. (21062690)
2010
13
Sternal cleft repair: a report of two cases and review of literature. (20859036)
2010
14
Case report. Isolated complete congenital sternal cleft in an adult: MDCT imaging findings. (19759206)
2009
15
Prenatal diagnosis of a complete sternal cleft in a child with PHACES syndrome-a case report. (19142902)
2009
16
Low cervical skin crease approach for superior sternal cleft repair. (19735841)
2009
17
The demonstration of the inferior sternal cleft using three-dimensional reconstruction: a case report. (19690785)
2009
18
Use of titanium plates in repair of adult complete sternal cleft. (19394848)
2009
19
Sternal cleft, a rare congenital anomaly. Report of the first Tunisian case. (19213519)
2008
20
Thymectomy to achieve primary closure of total sternal cleft. (19040914)
2008
21
Congenital sternal cleft in an adult male not associated with cardiac defects or ectopia cordis. (17462433)
2007
22
Sternal cleft--a natural absurdity or a surgical opportunity. (17336207)
2007
23
Superior sternal cleft, cutaneous, and airway haemangiomas. (17185427)
2007
24
Surgical repair of congenital sternal cleft in an adult to prevent traumatic pericardial rupture. (17151973)
2006
25
Surgical repair of combined gastroschisis and sternal cleft. (15991160)
2005
26
Midline raphAc, sternal cleft, and other midline abnormalities: a new dominant syndrome? (15810010)
2005
27
Superior sternal cleft associated with PHACES syndrome: postnatal sonographic findings. (12636335)
2003
28
Superior sternal cleft and minor hemangiomas in a newborn. (14577681)
2003
29
Sternal cleft: a surgical opportunity. (12596098)
2003
30
Primary repair of a sternal cleft in an infant with autogenous tissues. (17670117)
2003
31
Report of a child with aortic aneurysm, orofacial clefting, hemangioma, upper sternal defect, and marfanoid features: possible PHACE syndrome. (12116239)
2002
32
Complete congenital sternal cleft associated with pectus excavatum. (12224725)
2002
33
Superior congenital sternal cleft. (11536030)
2001
34
Congenital sternal cleft. (11254425)
2001
35
Two patients with varying combinations of sternal cleft, haemangiomas, midline abdominal raphe, coarctation of the aorta with a right aortic arch. (10826620)
2000
36
Upper sternal cleft associated with unusual symptoms. (11145410)
2000
37
Multiple pilomatricomas, sternal cleft and mild coagulative defect. (10721855)
2000
38
Combined repair of upper sternal cleft and tetralogy of Fallot in an infant. (9262621)
1997
39
Primary repair of complete sternal cleft with pectoralis major muscle flaps. (8619730)
1996
40
Prenatal diagnosis of a chest wall hamartoma and sternal cleft. (8807766)
1996
41
Complete congenital sternal cleft in an adult: repair by autogenous tissues. (8694629)
1996
42
Congenital skin fistula with sternal cleft. (7718480)
1995
43
Sternal cleft: case report and review of a series of nine patients. (8588577)
1995
44
Superior sternal cleft. (7875899)
1994
45
Sternal cleft associated with vascular anomalies and micrognathia. (8328853)
1993
46
Complete sternal cleft. (2609075)
1989
47
Superior sternal cleft. (3246403)
1988
48
Aneurysm of the ascending aorta associated with sternal cleft, cutaneous hemangioma, and occlusion of the right innominate artery in a neonate. (3541557)
1987
49
Superior sternal cleft: repair in the newborn. (4004402)
1985
50
Congenital upper sternal cleft: a case with successful surgical repair. (5419075)
1970

Genetic Variations for Sternal Cleft

Expression for genes affiliated with Sternal Cleft

Sources:
15Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Sternal Cleft.

Pathways for genes affiliated with Sternal Cleft

Compounds for genes affiliated with Sternal Cleft

GO Terms for genes affiliated with Sternal Cleft

Products for genes affiliated with Sternal Cleft

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  • Antibodies

Sources for Sternal Cleft

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet