MCID: STR044
MIFTS: 37

Steroid-Resistant Nephrotic Syndrome malady

Genetic diseases (common), Nephrological diseases categories
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Summaries for Steroid-Resistant Nephrotic Syndrome

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MalaCards based summary: Steroid-Resistant Nephrotic Syndrome is related to nephrotic syndrome and glomerulosclerosis. An important gene associated with Steroid-Resistant Nephrotic Syndrome is NPHS2 (nephrosis 2, idiopathic, steroid-resistant (podocin)), and among its related pathways are Cell junction organization and Nephrin interactions. The compounds puromycin aminonucleoside and lipid have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and heart, and related mouse phenotypes are growth/size/body and renal/urinary system.

Aliases & Classifications for Steroid-Resistant Nephrotic Syndrome

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Steroid-Resistant Nephrotic Syndrome, Aliases & Descriptions:

Name: Steroid-Resistant Nephrotic Syndrome 20 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Nephrological diseases


Related Diseases for Steroid-Resistant Nephrotic Syndrome

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Diseases related to Steroid-Resistant Nephrotic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome31.7NPHS1, NPHS2, CD2AP, WT1
2glomerulosclerosis30.6CD2AP, NPHS2, WT1, NPHS1
3nephrosis30.5NPHS2, NPHS1
4focal segmental glomerulosclerosis30.4NPHS1, WT1, CD2AP, NPHS2
5wilms tumor30.3WT1, CD2AP, NPHS2, NPHS1
6proteinuria30.3NPHS2, WT1, NPHS1, CD2AP
7glomerulonephritis30.2CD2AP, NPHS2, NPHS1
8hypothyroidism10.5
9nephrotic syndrome, idiopathic, steroid-resistant10.5
10sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis10.5
11familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis10.5
12sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.4
13sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes10.4
14sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis10.4
15familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis10.4
16familial idiopathic steroid-resistant nephrotic syndrome with minimal changes10.4
17familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.4
18sporadic idiopathic steroid-resistant nephrotic syndrome10.4
19sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy10.4
20denys-drash syndrome10.4WT1
21frasier syndrome10.3WT1
22multiple myeloma10.2
23systemic lupus erythematosus10.2
24anuria10.2
25proliferative glomerulonephritis10.2
26mesangial proliferative glomerulonephritis10.2
27cerebritis10.2
28sagittal sinus thrombosis10.2
29food allergy10.2
30lupus erythematosus10.2
31lymphopenia10.2
32myeloma10.2
33peritonitis10.2
34dense deposit disease10.2
35nephrotic syndrome type 310.2
36nephrotic syndrome, type 210.2
37nephrotic syndrome, type 410.2
38coenzyme q10 deficiency, primary, 610.2
39nephrotic syndrome, type 110.2
40nail-patella syndrome10.1NPHS2, CD2AP
41nephroblastoma10.0NPHS1, WT1
42nephritis10.0NPHS1, NPHS2
43pre-eclampsia10.0NPHS2, NPHS1
44primary hyperoxaluria10.0NPHS1, NPHS2
45diffuse mesangial sclerosis10.0NPHS1, WT1, NPHS2
46lipoid nephrosis9.9CD2AP, NPHS1, NPHS2
47membranous glomerulonephritis9.9NPHS1, NPHS2, CD2AP
48berger disease9.9NPHS1, CD2AP, NPHS2
49diabetic nephropathy9.9NPHS2, NPHS1
50chronic kidney failure9.9NPHS2, WT1, NPHS1

Graphical network of the top 20 diseases related to Steroid-Resistant Nephrotic Syndrome:



Diseases related to steroid-resistant nephrotic syndrome

Symptoms for Steroid-Resistant Nephrotic Syndrome

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Drugs & Therapeutics for Steroid-Resistant Nephrotic Syndrome

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Drug clinical trials:

Search ClinicalTrials for Steroid-Resistant Nephrotic Syndrome

Search NIH Clinical Center for Steroid-Resistant Nephrotic Syndrome

Genetic Tests for Steroid-Resistant Nephrotic Syndrome

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Genetic tests related to Steroid-Resistant Nephrotic Syndrome:

id Genetic test Affiliating Genes
1 Steroid-Resistant Nephrotic Syndrome20 NPHS2

Anatomical Context for Steroid-Resistant Nephrotic Syndrome

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MalaCards organs/tissues related to Steroid-Resistant Nephrotic Syndrome:

32
Testes, Kidney, Heart, T cells

Animal Models for Steroid-Resistant Nephrotic Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Steroid-Resistant Nephrotic Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.3WT1, CD2AP, NPHS2, NEIL1
2MP:00053677.5WT1, CD2AP, NPHS2, NPHS1, NEIL1
3MP:00053767.3NEIL1, NPHS1, NPHS2, CD2AP, WT1

Publications for Steroid-Resistant Nephrotic Syndrome

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Articles related to Steroid-Resistant Nephrotic Syndrome:

(show top 50)    (show all 228)
idTitleAuthorsYear
1
NPHS2 R229Q polymorphism in steroid resistant nephrotic syndrome: is it responsive to immunosuppressive therapy? (24519673)
2014
2
Reply to RE: Steroid-resistant nephrotic syndrome: impact of genetic testing. (25266195)
2014
3
NPHS2 Mutations in Steroid-Resistant Nephrotic Syndrome: A Mutation Update and the Associated Phenotypic Spectrum. (24227627)
2014
4
Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial. (24363128)
2013
5
R: Histological patterns of idiopathic steroid resistant nephrotic syndrome in Egyptian children: A single centre study. (24475443)
2013
6
A large intracardiac thrombus in a child with steroid-resistant nephrotic syndrome. (22813602)
2013
7
Wilms' tumor suppressor gene mutations in girls with sporadic isolated steroid-resistant nephrotic syndrome. (24338413)
2013
8
NPHS2 mutations in Indian children with sporadic early steroid resistant nephrotic syndrome. (22080622)
2012
9
Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency-x-linked recessive ichthyosis: a case report and review of literature. (22419362)
2012
10
Combined renin angiotensin blockade in childhood steroid-resistant nephrotic syndrome. (22621380)
2012
11
Histopathological spectrum of childhood idiopathic steroid-resistant nephrotic syndrome in Tunisia. (21387228)
2011
12
Novel mutations in steroid-resistant nephrotic syndrome diagnosed in Tunisian children. (21125408)
2011
13
Successful treatment of steroid-resistant nephrotic syndrome associated with WT1 mutations. (20191369)
2010
14
Plasmapheresis-induced clinical improvement in a patient with steroid-resistant nephrotic syndrome due to podocin (NPHS2) gene mutation. (21171529)
2010
15
Childhood idiopathic steroid resistant nephrotic syndrome in Southwestern Nigeria. (20814150)
2010
16
Treatment with Cyclophosphamide for steroid-resistant nephrotic syndrome in children. (21977148)
2010
17
Long-term outcome of children with steroid-resistant nephrotic syndrome treated with tacrolimus. (20217433)
2010
18
Successful use of single-dose rituximab for the maintenance of remission in a patient with steroid-resistant nephrotic syndrome. (19881243)
2009
19
Interleukin-18 expression in peripheral blood mononuclear cells in children with steroid-resistant nephrotic syndrome]. (19470251)
2009
20
Management and outcome of steroid-resistant nephrotic syndrome in children. (19841524)
2009
21
Clinical and epidemiological assessment of steroid-resistant nephrotic syndrome associated with the NPHS2 R229Q variant. (19145239)
2009
22
Cyclosporine and steroid therapy in children with steroid-resistant nephrotic syndrome. (19714370)
2009
23
Genetic variations of NPHS2 and WT1 genes in 15 Chinese children with sporadic steroid-resistant nephrotic syndrome]. (19573440)
2009
24
Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome. (18543005)
2008
25
Cyclosporin A is superior to cyclophosphamide in children with steroid-resistant nephrotic syndrome-a randomized controlled multicentre trial by the Arbeitsgemeinschaft fA1r PAodiatrische Nephrologie. (18481113)
2008
26
Steroid-resistant nephrotic syndrome. (18596732)
2008
27
Treatment of steroid-resistant nephrotic syndrome with cyclosporine: study of 17 cases and a literature review. (16358229)
2005
28
Mutations in NPHS2 in sporadic steroid-resistant nephrotic syndrome in Chinese children. (15769810)
2005
29
Steroid-resistant nephrotic syndrome and NPHS2 gene]. (15833180)
2005
30
Superior sagittal sinus thrombosis in steroid-resistant nephrotic syndrome. (15797188)
2005
31
Varicella-induced remission of steroid-resistant nephrotic syndrome in a child. (17642785)
2004
32
Enalapril dosage in steroid-resistant nephrotic syndrome. (14648339)
2004
33
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
34
NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence. (15253708)
2004
35
Three siblings with steroid-resistant nephrotic syndrome: new NPHS2 mutations in a Turkish family. (15264208)
2004
36
Cyclosporine in patients with steroid-resistant nephrotic syndrome: an open-label, nonrandomized, retrospective study. (15531003)
2004
37
Short term efficacy of intravenous dexamethasone and methylprednisolone therapy in steroid resistant nephrotic syndrome. (15523124)
2004
38
Efficacy of methylprednisolone pulse therapy in steroid-resistant nephrotic syndrome. (15322892)
2004
39
A gene locus for steroid-resistant nephrotic syndrome with deafness maps to chromosome 14q24.2. (12761252)
2003
40
NPHS2 mutations in sporadic steroid-resistant nephrotic syndrome in Japanese children. (12687458)
2003
41
Steroid resistant nephrotic syndrome. (12557961)
2002
42
Not all in the family: mutations of podocin in sporadic steroid-resistant nephrotic syndrome. (11805190)
2002
43
Steroid-resistant nephrotic syndrome at 4 months: no complications over 10 years. (10872200)
2000
44
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. (10742096)
2000
45
Successful management of steroid-resistant nephrotic syndrome using ibuprofen. (9021245)
1997
46
Presymptomatic diagnosis of familial steroid-resistant nephrotic syndrome. (8606597)
1996
47
Neurotoxicity of Cyclosporine A in therapy of steroid resistant nephrotic syndrome in a 10-year old boy. (8711194)
1996
48
Steroid resistant nephrotic syndrome associated with spondyloepiphyseal dysplasia, transient ischemic attacks and lymphopenia. (7736684)
1995
49
Inefficacy and toxicity of pefloxacin in focal and segmental glomerulosclerosis with steroid-resistant nephrotic syndrome. (8099164)
1993
50
Mercaptopurine in the treatment of steroid-resistant nephrotic syndrome. (5831732)
1965

Variations for Steroid-Resistant Nephrotic Syndrome

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Expression for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Expression patterns in normal tissues for genes affiliated with Steroid-Resistant Nephrotic Syndrome

Search GEO for disease gene expression data for Steroid-Resistant Nephrotic Syndrome.

Pathways for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Compounds for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Sources:
44Novoseek, 24HMDB
See all sources

Compounds related to Steroid-Resistant Nephrotic Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1puromycin aminonucleoside449.0CD2AP, NPHS2, NPHS1
2lipid448.9CD2AP, NPHS2, NPHS1
3cytosine44 249.9WT1, NEIL1
4creatinine448.9NPHS1, NPHS2, WT1
5steroid448.5WT1, CD2AP, NPHS2, NPHS1

GO Terms for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Cellular components related to Steroid-Resistant Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:0360579.4NPHS2, NPHS1
2protein complexGO:0432349.4NPHS2, NPHS1
3cell projectionGO:0429959.2NPHS1, COQ6
4membrane raftGO:0451219.1NPHS2, NPHS1

Biological processes related to Steroid-Resistant Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:0075889.4NPHS2, NPHS1
2glomerular basement membrane developmentGO:0328369.1WT1, NPHS1

Molecular functions related to Steroid-Resistant Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080229.1CD2AP, NEIL1

Products for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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  • Antibodies
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Sources for Steroid-Resistant Nephrotic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet