MCID: STR044
MIFTS: 31

Steroid-Resistant Nephrotic Syndrome malady

Genetic diseases (common), Nephrological diseases categories

Aliases & Classifications for Steroid-Resistant Nephrotic Syndrome

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Steroid-Resistant Nephrotic Syndrome, Aliases & Descriptions:

Name: Steroid-Resistant Nephrotic Syndrome 20 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Nephrological diseases


Summaries for Steroid-Resistant Nephrotic Syndrome

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MalaCards based summary: Steroid-Resistant Nephrotic Syndrome is related to nephrotic syndrome and wilms tumor. An important gene associated with Steroid-Resistant Nephrotic Syndrome is NPHS2 (nephrosis 2, idiopathic, steroid-resistant (podocin)), and among its related pathways are Cell junction organization and Nephrin interactions. The compounds puromycin aminonucleoside and lipid have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and heart, and related mouse phenotypes are growth/size/body and renal/urinary system.

Related Diseases for Steroid-Resistant Nephrotic Syndrome

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Diseases related to Steroid-Resistant Nephrotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome31.8NPHS1, NPHS2, CD2AP, WT1
2wilms tumor30.8NPHS1, WT1
3glomerulosclerosis30.6CD2AP, NPHS2, WT1, NPHS1
4nephrosis30.5NPHS2, NPHS1
5focal segmental glomerulosclerosis30.4NPHS1, WT1, CD2AP, NPHS2
6proteinuria30.3NPHS2, WT1, NPHS1, CD2AP
7glomerulonephritis30.2CD2AP, NPHS2, NPHS1
8nephrotic syndrome, idiopathic, steroid-resistant10.5
9sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis10.5
10familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis10.5
11hypothyroidism10.5
12familial steroid-resistant nephrotic syndrome with sensorineural deafness10.5
13sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.5
14sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes10.5
15sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis10.5
16familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis10.5
17familial idiopathic steroid-resistant nephrotic syndrome with minimal changes10.5
18familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.5
19sporadic idiopathic steroid-resistant nephrotic syndrome10.5
20sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy10.5
21denys-drash syndrome10.3WT1
22frasier syndrome10.3WT1
23systemic lupus erythematosus10.2
24nephrotic syndrome, type 210.2
25nephrotic syndrome, type 410.2
26galloway-mowat syndrome10.2
27nephrotic syndrome, type 110.2
28multiple myeloma10.2
29anuria10.2
30microcephaly10.2
31cerebritis10.2
32sagittal sinus thrombosis10.2
33proliferative glomerulonephritis10.2
34mesangial proliferative glomerulonephritis10.2
35food allergy10.2
36lupus erythematosus10.2
37lymphopenia10.2
38myeloma10.2
39peritonitis10.2
40thymoma10.2
41dense deposit disease10.2
42nail-patella syndrome10.1NPHS2, CD2AP
43nephritis10.0NPHS1, NPHS2
44preeclampsia/eclampsia 110.0NPHS2, NPHS1
45primary hyperoxaluria10.0NPHS1, NPHS2
46diffuse mesangial sclerosis10.0NPHS1, WT1, NPHS2
47lipoid nephrosis9.9CD2AP, NPHS1, NPHS2
48membranous glomerulonephritis, antenatal9.9NPHS1, NPHS2, CD2AP
49iga glomerulonephritis9.9NPHS1, CD2AP, NPHS2
50microvascular complications of diabetes 39.9NPHS2, NPHS1

Graphical network of the top 20 diseases related to Steroid-Resistant Nephrotic Syndrome:



Diseases related to steroid-resistant nephrotic syndrome

Symptoms for Steroid-Resistant Nephrotic Syndrome

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Drugs & Therapeutics for Steroid-Resistant Nephrotic Syndrome

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Drug clinical trials:

Search ClinicalTrials for Steroid-Resistant Nephrotic Syndrome

Search NIH Clinical Center for Steroid-Resistant Nephrotic Syndrome

Genetic Tests for Steroid-Resistant Nephrotic Syndrome

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Genetic tests related to Steroid-Resistant Nephrotic Syndrome:

id Genetic test Affiliating Genes
1 Steroid-Resistant Nephrotic Syndrome20 NPHS2

Anatomical Context for Steroid-Resistant Nephrotic Syndrome

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MalaCards organs/tissues related to Steroid-Resistant Nephrotic Syndrome:

31
Testes, Kidney, Heart, T cells

Animal Models for Steroid-Resistant Nephrotic Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Steroid-Resistant Nephrotic Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.3WT1, CD2AP, NPHS2, NEIL1
2MP:00053677.5WT1, CD2AP, NPHS2, NPHS1, NEIL1
3MP:00053767.3NEIL1, NPHS1, NPHS2, CD2AP, WT1

Publications for Steroid-Resistant Nephrotic Syndrome

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Articles related to Steroid-Resistant Nephrotic Syndrome:

(show top 50)    (show all 238)
idTitleAuthorsYear
1
Defects of CRB2 cause steroid-resistant nephrotic syndrome. (25557779)
2015
2
From microscopy to molecules: unraveling the pathogenesis of steroid-resistant nephrotic syndrome. (25899183)
2015
3
NPHS2 R229Q polymorphism in steroid resistant nephrotic syndrome: is it responsive to immunosuppressive therapy? (24519673)
2014
4
Reply to RE: Steroid-resistant nephrotic syndrome: impact of genetic testing. (25266195)
2014
5
Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial. (24363128)
2013
6
R: Histological patterns of idiopathic steroid resistant nephrotic syndrome in Egyptian children: A single centre study. (24475443)
2013
7
A large intracardiac thrombus in a child with steroid-resistant nephrotic syndrome. (22813602)
2013
8
Wilms' tumor suppressor gene mutations in girls with sporadic isolated steroid-resistant nephrotic syndrome. (24338413)
2013
9
NPHS2 mutations in Indian children with sporadic early steroid resistant nephrotic syndrome. (22080622)
2012
10
Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency-x-linked recessive ichthyosis: a case report and review of literature. (22419362)
2012
11
Histopathological spectrum of childhood idiopathic steroid-resistant nephrotic syndrome in Tunisia. (21387228)
2011
12
Novel mutations in steroid-resistant nephrotic syndrome diagnosed in Tunisian children. (21125408)
2011
13
Successful treatment of steroid-resistant nephrotic syndrome associated with WT1 mutations. (20191369)
2010
14
Plasmapheresis-induced clinical improvement in a patient with steroid-resistant nephrotic syndrome due to podocin (NPHS2) gene mutation. (21171529)
2010
15
Childhood idiopathic steroid resistant nephrotic syndrome in Southwestern Nigeria. (20814150)
2010
16
Treatment with Cyclophosphamide for steroid-resistant nephrotic syndrome in children. (21977148)
2010
17
Long-term outcome of children with steroid-resistant nephrotic syndrome treated with tacrolimus. (20217433)
2010
18
Successful use of single-dose rituximab for the maintenance of remission in a patient with steroid-resistant nephrotic syndrome. (19881243)
2009
19
Interleukin-18 expression in peripheral blood mononuclear cells in children with steroid-resistant nephrotic syndrome]. (19470251)
2009
20
Experience with tacrolimus in children with steroid-resistant nephrotic syndrome. (19499248)
2009
21
Management and outcome of steroid-resistant nephrotic syndrome in children. (19841524)
2009
22
Clinical and epidemiological assessment of steroid-resistant nephrotic syndrome associated with the NPHS2 R229Q variant. (19145239)
2009
23
Cyclosporine and steroid therapy in children with steroid-resistant nephrotic syndrome. (19714370)
2009
24
Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome. (18543005)
2008
25
Cyclosporin A is superior to cyclophosphamide in children with steroid-resistant nephrotic syndrome-a randomized controlled multicentre trial by the Arbeitsgemeinschaft fA1r PAodiatrische Nephrologie. (18481113)
2008
26
Steroid-resistant nephrotic syndrome. (18596732)
2008
27
Treatment of steroid-resistant nephrotic syndrome with cyclosporine: study of 17 cases and a literature review. (16358229)
2005
28
Mutations in NPHS2 in sporadic steroid-resistant nephrotic syndrome in Chinese children. (15769810)
2005
29
Steroid-resistant nephrotic syndrome and NPHS2 gene]. (15833180)
2005
30
Superior sagittal sinus thrombosis in steroid-resistant nephrotic syndrome. (15797188)
2005
31
Varicella-induced remission of steroid-resistant nephrotic syndrome in a child. (17642785)
2004
32
Enalapril dosage in steroid-resistant nephrotic syndrome. (14648339)
2004
33
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
34
NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence. (15253708)
2004
35
Three siblings with steroid-resistant nephrotic syndrome: new NPHS2 mutations in a Turkish family. (15264208)
2004
36
Cyclosporine in patients with steroid-resistant nephrotic syndrome: an open-label, nonrandomized, retrospective study. (15531003)
2004
37
Short term efficacy of intravenous dexamethasone and methylprednisolone therapy in steroid resistant nephrotic syndrome. (15523124)
2004
38
A gene locus for steroid-resistant nephrotic syndrome with deafness maps to chromosome 14q24.2. (12761252)
2003
39
NPHS2 mutations in sporadic steroid-resistant nephrotic syndrome in Japanese children. (12687458)
2003
40
Steroid resistant nephrotic syndrome. (12557961)
2002
41
Not all in the family: mutations of podocin in sporadic steroid-resistant nephrotic syndrome. (11805190)
2002
42
Steroid-resistant nephrotic syndrome at 4 months: no complications over 10 years. (10872200)
2000
43
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. (10742096)
2000
44
Successful management of steroid-resistant nephrotic syndrome using ibuprofen. (9021245)
1997
45
Steroid-resistant nephrotic syndrome associated with malignant thymoma. (8953125)
1996
46
Presymptomatic diagnosis of familial steroid-resistant nephrotic syndrome. (8606597)
1996
47
Neurotoxicity of Cyclosporine A in therapy of steroid resistant nephrotic syndrome in a 10-year old boy. (8711194)
1996
48
Steroid resistant nephrotic syndrome associated with spondyloepiphyseal dysplasia, transient ischemic attacks and lymphopenia. (7736684)
1995
49
Inefficacy and toxicity of pefloxacin in focal and segmental glomerulosclerosis with steroid-resistant nephrotic syndrome. (8099164)
1993
50
Mercaptopurine in the treatment of steroid-resistant nephrotic syndrome. (5831732)
1965

Variations for Steroid-Resistant Nephrotic Syndrome

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Expression for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Search GEO for disease gene expression data for Steroid-Resistant Nephrotic Syndrome.

Pathways for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Compounds for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Sources:
43Novoseek, 24HMDB
See all sources

Compounds related to Steroid-Resistant Nephrotic Syndrome according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1puromycin aminonucleoside439.0CD2AP, NPHS2, NPHS1
2lipid438.9CD2AP, NPHS2, NPHS1
3cytosine43 249.9WT1, NEIL1
4creatinine438.9NPHS1, NPHS2, WT1
5steroid438.5WT1, CD2AP, NPHS2, NPHS1

GO Terms for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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Cellular components related to Steroid-Resistant Nephrotic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:00360579.4NPHS2, NPHS1
2protein complexGO:00432349.4NPHS2, NPHS1
3cell projectionGO:00429959.2NPHS1, COQ6
4membrane raftGO:00451219.1NPHS2, NPHS1

Biological processes related to Steroid-Resistant Nephrotic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:00075889.4NPHS2, NPHS1
2glomerular basement membrane developmentGO:00328369.1WT1, NPHS1

Molecular functions related to Steroid-Resistant Nephrotic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:00080229.1CD2AP, NEIL1

Products for genes affiliated with Steroid-Resistant Nephrotic Syndrome

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Steroid-Resistant Nephrotic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet