SJS
MCID: STV001
MIFTS: 49

Stevens-Johnson Syndrome (SJS) malady

Summaries for Stevens-Johnson Syndrome

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Stevens-johnson syndrome (sjs), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. this disorder affects the skin, mucous membranes and eyes. stevens-johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age. it is an emergency medical condition that usually requires hospitalization. treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications. last updated: 11/22/2010

MalaCards: Stevens-Johnson Syndrome, also known as erythema multiforme major, is related to erythema multiforme and systemic lupus erythematosus. An important gene associated with Stevens-Johnson Syndrome is HLA-B (major histocompatibility complex, class I, B), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds (glc)4 and chromium have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and t cells.

Wikipedia:63 Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two forms of a... more...

Description from OMIM:46 608579

Aliases & Classifications for Stevens-Johnson Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH
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Aliases & Descriptions:

stevens-johnson syndrome 8 42 46 10 44 30 60
erythema multiforme major 42 60
schwartz-jampel syndrome 60
sjs 42


External Ids:

Disease Ontology8 DOID:0050426
MeSH34 D013262

Related Diseases for Stevens-Johnson Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Stevens-Johnson Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1erythema multiforme31.5HSPG2
2systemic lupus erythematosus30.7KLRD1, KLRC2, HSPG2, FAS, FASLG
3myeloma30.7FAS, FASLG, HLA-B
4hepatitis30.6HSPG2, GZMB, FASLG, HLA-B
5dermatitis30.5CCL22, CCL17, GZMB
6purpura30.3HSPG2
7arthritis30.3HLA-B, GZMB
8influenza30.3HLA-B, GZMB
9rheumatoid arthritis30.3KLRD1, KLRC2, HSPG2, GZMB, FAS, FASLG
10squamous cell carcinoma30.3HSPG2, GZMB, FAS, FASLG, HLA-B, TGM1
11liver cirrhosis30.3GZMB
12sjogren's syndrome29.9HSPG2, GZMB, FAS, FASLG
13pneumonia10.9
14cicatricial pemphigoid10.6
15adult syndrome10.6
16stuve-wiedemann syndrome10.6
17burns10.6
18lupus erythematosus10.6
19dry eye syndrome10.5
20multiple myeloma10.5
21blepharospasm10.4
22bronchiolitis obliterans10.4
23bronchiolitis10.4
24conjunctival pigmentation10.3
25cataract10.3
26conjunctivitis10.3
27eosinophilia10.3
28herpes simplex10.3
29image syndrome10.3
30cleft palate10.3
31myopathy10.3
32kyphomelic dysplasia10.3
33crohn's disease10.2
34exfoliation syndrome10.2
35epstein-barr virus hepatitis10.2
36folliculitis10.2
37visceral leishmaniasis10.2
38adult t-cell leukemia10.2
39vulvovaginitis10.2
40dacryocystocele10.2
41parotitis10.2
42herpes zoster10.2
43adult lymphoma10.2
44neuroleptic malignant syndrome10.2
45orbital cyst10.2
46diffuse large b-cell lymphoma10.2
47bronchopneumonia10.2
48acute myocarditis10.2
49cavernous hemangioma10.2
50dermatitis herpetiformis10.2

Graphical network of the top 20 diseases related to Stevens-Johnson Syndrome:



Diseases related to stevens-johnson syndrome

Clinical Features for Stevens-Johnson Syndrome

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46OMIM
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Clinical features from OMIM:

608579

Drugs & Therapeutics for Stevens-Johnson Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stevens-Johnson Syndrome

Drug clinical trials:

Search ClinicalTrials for Stevens-Johnson Syndrome

Search NIH Clinical Center for Stevens-Johnson Syndrome

Search CenterWatch for Stevens-Johnson Syndrome

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stevens-Johnson Syndrome cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stevens-Johnson Syndrome:
Cultivated corneal epithelial stem cells for treatment of ocular surface damage
Embryonic/Adult Cultured Cells Related to Stevens-Johnson Syndrome:
Limbal corneal epithelial stem cells, PMID: 23055668

Genetic Tests for Stevens-Johnson Syndrome

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Anatomical Context for Stevens-Johnson Syndrome

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32MalaCards
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MalaCards organs/tissues related to Stevens-Johnson Syndrome:

32
Skin, Eye, T cells, Liver, Testes, Colon, Salivary gland, Lung, Monocytes, B cells, Bronchial epithelium

Animal Models for Stevens-Johnson Syndrome or affiliated genes

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Publications for Stevens-Johnson Syndrome

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50PubMed
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Articles related to Stevens-Johnson Syndrome:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Late onset imatinib-induced Stevens-Johnson syndrome. (24399835)
2014
2
Stevens-johnson syndrome, mucositis, or something else? (24435604)
2014
3
Bronchiolitis Obliterans Associated with Stevens-Johnson Syndrome and Response to Azathioprine. (24014187)
2013
4
Current ophthalmologic treatment strategies for acute and chronic Stevens-Johnson syndrome and toxic epidermal necrolysis. (23680755)
2013
5
Intravenous immune globulin therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis complicated by hemolysis leading to pigment nephropathy and hemodialysis. (23673282)
2013
6
Stevens-Johnson/toxic epidermal necrolysis overlap syndrome following lenalidomide treatment for multiple myeloma relapse after allogeneic transplantation. (21494796)
2012
7
Stevens-Johnson syndrome and toxic epidermal necrolysis in patients with lupus erythematosus: a descriptive study of 17 cases from a national registry and review of the literature. (22014091)
2012
8
Toxic epidermal necrolysis and Stevens-Johnson syndrome at the Prague Burn Centre 1998-2008. (21668825)
2012
9
Stevens-Johnson syndrome after Mycoplasma pneumonia infection in pediatric post-liver transplant recipient: case report and review of the literature. (21176015)
2012
10
Pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. (22212057)
2012
11
Internet accounts of serious adverse drug reactions: a study of experiences of Stevens-Johnson syndrome and toxic epidermal necrolysis. (23058037)
2012
12
A systematic review of treatment of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children. (21467603)
2011
13
Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases. (21731276)
2011
14
Liver cirrhosis as a delayed complication of Stevens-Johnson syndrome. (21841341)
2011
15
Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of treatment options. (21410610)
2011
16
Stevens-Johnson syndrome secondary to oseltamivir (Tamiflu). (20132714)
2010
17
Ophthalmic Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis and Relation to SCORTEN. (20619392)
2010
18
Stevens-Johnson syndrome and toxic epidermal necrolysis: what do we know? (20844465)
2010
19
Lenalidomide: Stevens-Johnson syndrome. (20740722)
2010
20
Severe cutaneous adverse reactions: acute generalized exanthematous pustulosis, toxic epidermal necrolysis and Stevens-Johnson syndrome. (20609860)
2010
21
Stevens-Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentations. (19874350)
2010
22
HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. (21204807)
2010
23
The role of systemic corticosteroid therapy in erythema multiforme major and stevens-johnson syndrome: a review of past and current opinions. (20729944)
2009
24
Stevens-Johnson Syndrome triggered by chemical hair relaxer: a case report. (19918477)
2009
25
Relevance and consequences of erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in gynecology. (19277691)
2009
26
Granulysin as a marker for early diagnosis of the Stevens-Johnson syndrome. (19805776)
2009
27
Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. (18855540)
2008
28
Stevens-Johnson syndrome and toxic epidermal necrolysis induced by amifostine during head and neck radiotherapy. (18328585)
2008
29
The ophthalmologic management of acute Stevens-Johnson syndrome. (18418506)
2008
30
Nevirapine-induced Stevens-Johnson syndrome in a pediatric patient. (18304177)
2008
31
Lamotrigine-induced Stevens-Johnson syndrome. (17244876)
2007
32
Intravenous immunoglobulins for the management of Stevens-Johnson syndrome with minimal skin manifestations. (17008995)
2007
33
Soluble Fas ligand: is it a critical mediator of toxic epidermal necrolysis and Stevens-Johnson syndrome? (17363955)
2007
34
Technique of amniotic membrane transplant dressing in the management of acute Stevens-Johnson syndrome. (17947270)
2007
35
Available and affordable pre-definitive surgical management of symblepharon in end stage stevens johnson syndrome: a case report. (17356599)
2007
36
Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006. (17713361)
2007
37
Immunohistochemical expression of apoptotic markers in drug-induced erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. (17880768)
2007
38
Picture of the month. Stevens-Johnson Syndrome. (16894078)
2006
39
Functional visual acuity in Stevens-Johnson syndrome. (17157576)
2006
40
The use of autologous serum in the development of corneal and oral epithelial equivalents in patients with Stevens-Johnson syndrome. (16505023)
2006
41
Controversy in the use of high-dose systemic steroids in the acute care of patients with Stevens-Johnson syndrome. (16199965)
2005
42
Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome. (15878074)
2005
43
Dacryocystoceles in the aftermath of Stevens-Johnson syndrome. (15778676)
2005
44
Carbamazepine--the commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: a study of 7 years. (16394456)
2005
45
A case of rofecoxib-associated stevens-johnson syndrome with corneal and conjunctival changes. (15448505)
2004
46
Medical genetics: a marker for Stevens-Johnson syndrome. (15057820)
2004
47
Stevens-Johnson syndrome associated with ciprofloxacin: a review of adverse cutaneous events reported in Sweden as associated with this drug. (14576649)
2003
48
Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in northeastern Malaysia. (9679693)
1998
49
Mycoplasma pneumoniae infection is associated with Stevens-Johnson syndrome, not erythema multiforme (von Hebra). (8912572)
1996
50
Orbital cyst in a patient with Stevens-Johnson syndrome. (1468225)
1992

Genetic Variations for Stevens-Johnson Syndrome

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Expression for genes affiliated with Stevens-Johnson Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stevens-Johnson Syndrome

Search GEO for disease gene expression data for Stevens-Johnson Syndrome.

Pathways for genes affiliated with Stevens-Johnson Syndrome

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53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Stevens-Johnson Syndrome

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1(glc)44410.6FAS, FASLG
2chromium4410.6FASLG, GNLY, GZMB
3concanamycin a44 5911.5GZMB, GNLY, FAS, FASLG
4ivig4410.5GZMB, FAS, FASLG
5atpo44 2811.5FASLG, FAS
6phosphatidylserine44 28 1112.5FASLG, FAS, GZMB, HSPG2
7c2ceramide4410.5HSPG2, FAS, FASLG
8tacrolimus44 49 1112.4CCL22, CCL17, GZMB, FASLG, HLA-B
9rottlerin4410.4HSPG2, FAS, FASLG
10pge24410.4HSPG2, CCL22, FASLG, HLA-B, F2RL2
11cyclosporin a44 28 5912.4CCL22, CCL17, GZMB, FAS, FASLG, HLA-B
12lactate4410.3F2RL2, HLA-B, FASLG, FAS, GZMB
13oligonucleotide4410.3CCL22, GZMB, GNLY, FAS, FASLG, HLA-B
14allopurinol44 49 1112.3TCF19, CCHCR1, PSORS1C1, PSORS1C3, PPIAP9, HLA-B
15nitric oxide44 11 2412.3CCL17, GZMB, FAS, FASLG, HLA-B, TGM1
16dexamethasone44 49 28 1113.3HSPG2, CCL22, CCL17, GZMB, FAS, FASLG
17cytarabine44 49 1112.3FASLG, FAS, GZMB
18fibrinogen4410.2CCL22, CCL17, HLA-B, F2RL2
19rantes4410.2CCL22, CCL17, GZMB, GNLY, FAS, FASLG
20retinoic acid44 2411.2HSPG2, GZMB, FAS, FASLG, HLA-B, TGM1
21ly2940024410.1HSPG2, GZMB, FAS, FASLG
22calcium44 49 11 2412.9CCL22, CCL17, GZMB, FASLG, HLA-B, F2RL2
23steroid449.8CCHCR1, GZMB, GNLY, HLA-B, TGM1

GO Terms for genes affiliated with Stevens-Johnson Syndrome

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16Gene Ontology
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Biological processes related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
2immune responseGO:00695510.2HLA-B, FASLG, CCL17, CCL22
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS

Molecular functions related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.2FAS, KLRC2, KLRD1

Products for genes affiliated with Stevens-Johnson Syndrome

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Sources for Stevens-Johnson Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet