SJS
MCID: STV001
MIFTS: 49

Stevens-Johnson Syndrome (SJS) malady

Summaries for Stevens-Johnson Syndrome

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Stevens-johnson syndrome (sjs), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. this disorder affects the skin, mucous membranes and eyes. stevens-johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age. it is an emergency medical condition that usually requires hospitalization. treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications. last updated: 11/22/2010

MalaCards: Stevens-Johnson Syndrome, also known as erythema multiforme major, is related to erythema multiforme and systemic lupus erythematosus. An important gene associated with Stevens-Johnson Syndrome is HLA-B (major histocompatibility complex, class I, B), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds (glc)4 and chromium have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and t cells.

Wikipedia:63 Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two forms of a... more...

Description from OMIM:46 608579

Aliases & Classifications for Stevens-Johnson Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH
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Aliases & Descriptions:

stevens-johnson syndrome 8 42 46 10 44 30 60
erythema multiforme major 42 60
schwartz-jampel syndrome 60
sjs 42


External Ids:

Disease Ontology8 DOID:0050426
MeSH34 D013262

Related Diseases for Stevens-Johnson Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Stevens-Johnson Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1erythema multiforme31.5HSPG2
2systemic lupus erythematosus30.7KLRD1, KLRC2, HSPG2, FAS, FASLG
3myeloma30.7FAS, FASLG, HLA-B
4hepatitis30.6HSPG2, GZMB, FASLG, HLA-B
5dermatitis30.5CCL22, CCL17, GZMB
6purpura30.3HSPG2
7arthritis30.3HLA-B, GZMB
8influenza30.3HLA-B, GZMB
9rheumatoid arthritis30.3KLRD1, KLRC2, HSPG2, GZMB, FAS, FASLG
10squamous cell carcinoma30.3HSPG2, GZMB, FAS, FASLG, HLA-B, TGM1
11liver cirrhosis30.3GZMB
12sjogren's syndrome29.9HSPG2, GZMB, FAS, FASLG
13pneumonia10.9
14cicatricial pemphigoid10.6
15adult syndrome10.6
16stuve-wiedemann syndrome10.6
17burns10.6
18lupus erythematosus10.6
19dry eye syndrome10.5
20multiple myeloma10.5
21blepharospasm10.4
22bronchiolitis obliterans10.4
23bronchiolitis10.4
24conjunctival pigmentation10.3
25cataract10.3
26conjunctivitis10.3
27eosinophilia10.3
28herpes simplex10.3
29image syndrome10.3
30cleft palate10.3
31myopathy10.3
32kyphomelic dysplasia10.3
33crohn's disease10.2
34exfoliation syndrome10.2
35epstein-barr virus hepatitis10.2
36folliculitis10.2
37visceral leishmaniasis10.2
38adult t-cell leukemia10.2
39vulvovaginitis10.2
40dacryocystocele10.2
41parotitis10.2
42herpes zoster10.2
43adult lymphoma10.2
44neuroleptic malignant syndrome10.2
45orbital cyst10.2
46diffuse large b-cell lymphoma10.2
47bronchopneumonia10.2
48acute myocarditis10.2
49cavernous hemangioma10.2
50dermatitis herpetiformis10.2

Graphical network of the top 20 diseases related to Stevens-Johnson Syndrome:



Diseases related to stevens-johnson syndrome

Clinical Features for Stevens-Johnson Syndrome

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46OMIM
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Clinical features from OMIM:

608579

Drugs & Therapeutics for Stevens-Johnson Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stevens-Johnson Syndrome

Drug clinical trials:

Search ClinicalTrials for Stevens-Johnson Syndrome

Search NIH Clinical Center for Stevens-Johnson Syndrome

Search CenterWatch for Stevens-Johnson Syndrome

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stevens-Johnson Syndrome cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stevens-Johnson Syndrome:
Cultivated corneal epithelial stem cells for treatment of ocular surface damage
Embryonic/Adult Cultured Cells Related to Stevens-Johnson Syndrome:
Limbal corneal epithelial stem cells, PMID: 23055668

Genetic Tests for Stevens-Johnson Syndrome

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Anatomical Context for Stevens-Johnson Syndrome

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32MalaCards
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MalaCards organs/tissues related to Stevens-Johnson Syndrome:

32
Skin, Eye, T cells, Liver, Salivary gland, Colon, Lung, Testes, Monocytes, Bronchial epithelium, B cells

Animal Models for Stevens-Johnson Syndrome or affiliated genes

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Publications for Stevens-Johnson Syndrome

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50PubMed
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Articles related to Stevens-Johnson Syndrome:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Folliculitis in clinically "quiet" chronic stevens-johnson syndrome. (24398503)
2014
2
Genetic association of IFN-I^ +874T/A polymorphism in Mexican patients with drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. (23224615)
2013
3
Stevens-Johnson Syndrome and toxic epidermal necrolysis: improving the support to victims. (23329542)
2013
4
Severe gynecologic sequelae of Stevens-Johnson syndrome and toxic epidermal necrolysis caused by ibuprofen: a case report. (23947089)
2013
5
Mycoplasma pneumoniae with atypical stevens-johnson syndrome: a diagnostic challenge. (23365770)
2013
6
A review of causes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children. (23873883)
2013
7
HLA-B*5801 should be used to screen for risk of Stevens-Johnson syndrome in family members of Han Chinese patients commencing allopurinol therapy. (23280169)
2013
8
Prompt versus delayed amniotic membrane application in a patient with acute Stevens-Johnson syndrome. (23754867)
2013
9
Risk of nevirapine-associated Stevens-Johnson syndrome among HIV-infected pregnant women: the Medunsa National Pharmacovigilance Centre, 2007 - 2012. (23971123)
2013
10
Efficacy of cyclosporine 0.05% eye drops in Stevens Johnson syndrome with chronic dry eye. (23289903)
2013
11
Quetiapine- and valproate-associated neutropenia and thrombocytopenia after lamotrigine-induced Steven-Johnson syndrome. (22217948)
2012
12
Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese. (22277675)
2012
13
Stevens-Johnson syndrome without skin lesions (Fuchs syndrome): a literature review of adult cases with Mycoplasma cause. (22911206)
2012
14
Successful treatment of acute ocular involvement in Stevens-Johnson syndrome with amniotic membrane transplantation: a case report. (23217513)
2012
15
The role of prior corticosteroid use on the clinical course of Stevens-Johnson syndrome and toxic epidermal necrolysis: a case-control analysis of patients selected from the multinational EuroSCAR and RegiSCAR studies. (22639874)
2012
16
Distinguishing between erythema multiforme major and Stevens-Johnson syndrome/toxic epidermal necrolysis immunopathologically. (22458564)
2012
17
Acquired labial sinechiae and hydrocolpos secondary to Stevens-Johnson syndrome. (22921694)
2012
18
Toll-like receptor 9 polymorphism in patients with erythema multiforme, Stevens Johnson syndrome and Stevens Johnson syndrome/toxic epidermal necrolysis overlap syndrome. (21682079)
2011
19
Role of common genetic variants on the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis. (21692608)
2011
20
Stevens-Johnson syndrome triggered by seasonal influenza vaccination and flucloxacillin: a pathogenetic hypothesis. (21680282)
2011
21
Management of acute Stevens-Johnson syndrome and toxic epidermal necrolysis utilizing amniotic membrane and topical corticosteroids. (20005508)
2010
22
ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis. (20375998)
2010
23
CD94/NKG2C is a killer effector molecule in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. (20132973)
2010
24
Oxcarbazepine-induced Stevens-Johnson syndrome: a case report. (19321411)
2009
25
Stevens-Johnson syndrome: a case report. (19912981)
2009
26
Mucous Membrane Grafting For Lid Margin Keratinization in Stevens Johnson Syndrome (SJS): Results. (20023587)
2009
27
Review of intravenous immunoglobulin in the treatment of stevens-johnson syndrome and toxic epidermal necrolysis. (20967183)
2009
28
Association of Fas Ligand gene polymorphism with Stevens-Johnson syndrome. (18577653)
2008
29
Topical bevacizumab and ocular surface neovascularization in patients with stevens-johnson syndrome. (18245970)
2008
30
Stevens-Johnson syndrome associated with oral minoxidil: a case report. (17347980)
2007
31
Stevens-Johnson syndrome associated with brucella infection. (17845180)
2007
32
Conjunctival pigmentation in Stevens-Johnson syndrome. (17984506)
2007
33
Stevens-Johnson syndrome without skin lesions. (18033843)
2007
34
Practical guidelines for the management of toxic epidermal necrolysis and Stevens-Johnson syndrome. (17910723)
2007
35
Cutaneous reactions simulating erythema multiforme and Stevens Johnson syndrome due to occupational exposure to a plant-growth regulator. (17921614)
2007
36
Ocular manifestations and complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: an Asian series. (17313402)
2007
37
Bronchiolitis obliterans: a rare chronic pulmonary complication associated with Stevens-Johnson syndrome. (17845150)
2007
38
Toxic epidermal necrolysis and Stevens Johnson syndrome: our current understanding. (17075281)
2006
39
Intravenous immunoglobulin use in patients with toxic epidermal necrolysis and Stevens-Johnson syndrome. (17173470)
2006
40
Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome. (17138682)
2006
41
Stevens - Johnson syndrome due to nevirapine. (16615847)
2005
42
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. (15824335)
2005
43
Benign oesophageal stricture--a sequel of Stevens Johnson syndrome. (16131782)
2005
44
Stevens-Johnson syndrome induced by paclitaxel in a patient with squamous cell carcinoma of the lung: a case report. (15154637)
2004
45
Stevens - johnson syndrome induced by sodium valproate. (21224910)
2004
46
Esophageal stricture as a late sequel of Stevens-Johnson syndrome in adults: incidental detection because of foreign body impaction. (14997151)
2004
47
Stevens-Johnson syndrome after amifostine during radiotherapy. (15090014)
2004
48
Successful intravenous human immunoglobulin treatment of drug-induced Stevens-Johnson syndrome in a dog. (15266858)
2004
49
Corticosteroid treatment of erythema multiforme major (Stevens-Johnson syndrome) in children. (9039508)
1997
50
Correction of entropion from Stevens-Johnson syndrome: use of nasal septum and mucosa for severely cicatrized eyelid entropion. (779733)
1976

Genetic Variations for Stevens-Johnson Syndrome

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Expression for genes affiliated with Stevens-Johnson Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stevens-Johnson Syndrome

Search GEO for disease gene expression data for Stevens-Johnson Syndrome.

Pathways for genes affiliated with Stevens-Johnson Syndrome

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53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Stevens-Johnson Syndrome

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1(glc)44410.6FAS, FASLG
2chromium4410.6FASLG, GNLY, GZMB
3concanamycin a44 5911.5GZMB, GNLY, FAS, FASLG
4ivig4410.5GZMB, FAS, FASLG
5atpo44 2811.5FASLG, FAS
6phosphatidylserine44 28 1112.5FASLG, FAS, GZMB, HSPG2
7c2ceramide4410.5HSPG2, FAS, FASLG
8tacrolimus44 49 1112.4CCL22, CCL17, GZMB, FASLG, HLA-B
9rottlerin4410.4HSPG2, FAS, FASLG
10pge24410.4HSPG2, CCL22, FASLG, HLA-B, F2RL2
11cyclosporin a44 28 5912.4CCL22, CCL17, GZMB, FAS, FASLG, HLA-B
12lactate4410.3F2RL2, HLA-B, FASLG, FAS, GZMB
13oligonucleotide4410.3CCL22, GZMB, GNLY, FAS, FASLG, HLA-B
14allopurinol44 49 1112.3TCF19, CCHCR1, PSORS1C1, PSORS1C3, PPIAP9, HLA-B
15nitric oxide44 11 2412.3CCL17, GZMB, FAS, FASLG, HLA-B, TGM1
16dexamethasone44 49 28 1113.3HSPG2, CCL22, CCL17, GZMB, FAS, FASLG
17cytarabine44 49 1112.3FASLG, FAS, GZMB
18fibrinogen4410.2CCL22, CCL17, HLA-B, F2RL2
19rantes4410.2CCL22, CCL17, GZMB, GNLY, FAS, FASLG
20retinoic acid44 2411.2HSPG2, GZMB, FAS, FASLG, HLA-B, TGM1
21ly2940024410.1HSPG2, GZMB, FAS, FASLG
22calcium44 49 11 2412.9CCL22, CCL17, GZMB, FASLG, HLA-B, F2RL2
23steroid449.8CCHCR1, GZMB, GNLY, HLA-B, TGM1

GO Terms for genes affiliated with Stevens-Johnson Syndrome

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16Gene Ontology
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Biological processes related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
2immune responseGO:00695510.2HLA-B, FASLG, CCL17, CCL22
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS

Molecular functions related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.2FAS, KLRC2, KLRD1

Products for genes affiliated with Stevens-Johnson Syndrome

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Sources for Stevens-Johnson Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet