SJS
MCID: STV001
MIFTS: 48

Stevens-Johnson Syndrome (SJS) malady

Summaries for Stevens-Johnson Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Stevens-johnson syndrome (sjs), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. this disorder affects the skin, mucous membranes and eyes. stevens-johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age. it is an emergency medical condition that usually requires hospitalization. treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications. last updated: 11/22/2010

MalaCards: Stevens-Johnson Syndrome, also known as erythema multiforme major, is related to toxic epidermal necrolysis and erythema multiforme. An important gene associated with Stevens-Johnson Syndrome is HLA-B (major histocompatibility complex, class I, B), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds (glc)4 and chromium have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lung.

Wikipedia:64 Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two forms of a... more...

Description from OMIM:47 608579

Aliases & Classifications for Stevens-Johnson Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 35MeSH
See all sources

Aliases & Descriptions:

stevens-johnson syndrome 8 43 47 10 45 31 61
erythema multiforme major 43 61
schwartz-jampel syndrome 61
sjs 43


External Ids:

Disease Ontology8 DOID:0050426
MeSH35 D013262

Related Diseases for Stevens-Johnson Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Stevens-Johnson Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1toxic epidermal necrolysis32.0HSPG2, GZMB, FAS, FASLG
2erythema multiforme31.5HSPG2
3systemic lupus erythematosus30.7KLRD1, KLRC2, HSPG2, FAS, FASLG
4arthritis30.3HLA-B, GZMB
5hepatitis c30.3FAS, HSPG2
6hepatitis b30.3HLA-B, GZMB
7squamous cell carcinoma30.3HSPG2, GZMB, FAS, FASLG, HLA-B, TGM1
8sjogren's syndrome29.9HSPG2, GZMB, FAS, FASLG
9n syndrome11.4
10myotonia10.8
11cicatricial pemphigoid10.6
12adult syndrome10.6
13ocular cicatricial pemphigoid10.6
14stuve-wiedemann syndrome10.6
15chondrodysplasia10.5
16bronchiolitis obliterans10.5
17bronchiolitis10.5
18blepharospasm10.5
19kyphomelic dysplasia10.5
20burns10.4
21conjunctival pigmentation10.4
22micro syndrome10.4
23char syndrome10.4
24bod syndrome10.4
25image syndrome10.4
26cytomegalovirus infection10.4
27hypersensitivity syndrome, carbamazepine-induced10.4
28acute generalized exanthematous pustulosis10.4
29cleft palate10.3
30endplate acetylcholinesterase deficiency10.3
31crohn's disease10.2
32epstein-barr virus hepatitis10.2
33folliculitis10.2
34hepatitis e10.2
35visceral leishmaniasis10.2
36adult t-cell leukemia10.2
37dacryocystocele10.2
38parotitis10.2
39herpes zoster10.2
40adult lymphoma10.2
41neuroleptic malignant syndrome10.2
42orbital cyst10.2
43diffuse large b-cell lymphoma10.2
44bronchopneumonia10.2
45hepatitis a10.2
46acute myocarditis10.2
47smallpox10.2
48stomatitis10.2
49t-cell leukemia10.2
50tetanus10.2

Graphical network of the top 20 diseases related to Stevens-Johnson Syndrome:



Diseases related to stevens-johnson syndrome

Clinical Features for Stevens-Johnson Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608579

Drugs & Therapeutics for Stevens-Johnson Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Stevens-Johnson Syndrome

Drug clinical trials:

Search ClinicalTrials for Stevens-Johnson Syndrome

Search NIH Clinical Center for Stevens-Johnson Syndrome

Search CenterWatch for Stevens-Johnson Syndrome

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stevens-Johnson Syndrome cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stevens-Johnson Syndrome:
Cultivated corneal epithelial stem cells for treatment of ocular surface damage
Embryonic/Adult Cultured Cells Related to Stevens-Johnson Syndrome:
Limbal corneal epithelial stem cells, PMID: 23055668

Genetic Tests for Stevens-Johnson Syndrome

Anatomical Context for Stevens-Johnson Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Stevens-Johnson Syndrome:

33
Skin, Liver, Lung, Whole blood, Colon, Salivary gland, Monocytes, T cells, B cells, Bronchial epithelium

Animal Models for Stevens-Johnson Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Stevens-Johnson Syndrome

Sources:
51PubMed
See all sources

Articles related to Stevens-Johnson Syndrome:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Stevens-Johnson syndrome and toxic epidermal necrolysis in children. (24028417)
2013
2
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (23360455)
2013
3
HLA-B*58:01 is a risk factor for allopurinol-induced DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis in a Portuguese population. (23600531)
2013
4
Mucosal complications of modified osteo-odonto keratoprosthesis in chronic Stevens-Johnson syndrome. (23958700)
2013
5
Reactivation of cytomegalovirus in a patient with stevens-johnson syndrome-toxic epidermal necrolysis. (24031112)
2013
6
Placement of ProKera in the management of ocular manifestations of acute Stevens-Johnson syndrome in an outpatient. (22683916)
2013
7
Stevens-Johnson syndrome and toxic epidermal necrolysis in sub-Saharan Africa: a multicentric study in four countries. (23330601)
2013
8
Intravenous immune globulin therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis complicated by hemolysis leading to pigment nephropathy and hemodialysis. (23673282)
2013
9
HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications. (22912896)
2012
10
Sequential Stevens-Johnson syndrome and photo-recall phenomenon. (22091553)
2012
11
Pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. (22212057)
2012
12
Spontaneous adverse event reports of Stevens-Johnson syndrome/toxic epidermal necrolysis: detecting associations with medications. (22139991)
2012
13
Rituxan is not associated with Stevens Johnson Syndrome. (21525404)
2011
14
Fuchs syndrome associated with Mycoplasma pneumoniae (Stevens-Johnson syndrome without skin lesions). (20678095)
2011
15
Phenytoin-induced Stevens-Johnson syndrome with negative HLA-B*1502 allele in mainland China: two cases. (21334226)
2011
16
Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of treatment options. (21410610)
2011
17
Carbamazepine-Induced Stevens-Johnson Syndrome Sparing the Skin Previously Affected by Herpes Zoster Infection in a Patient with Systemic Lupus Erythematosus: A Reverse Isotopic Phenomenon. (21076686)
2010
18
Successfully changing an ICD-9 diagnosis code: the ABA experience for Stevens-Johnson syndrome and toxic epidermal necrolysis. (20061850)
2010
19
Labial salivary gland transplantation for severe dry eye due to chemical burns and Stevens-Johnson syndrome. (20489543)
2010
20
Stevens-Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentations. (19874350)
2010
21
HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. (21204807)
2010
22
Stevens-Johnson syndrome and toxic epidermal necrolysis: consequence of treatment of an emerging pathogen. (19687711)
2009
23
Stevens-Johnson Syndrome and toxic epidermal necrolysis overlap due to oral temozolomide and cranial radiotherapy. (19489660)
2009
24
Docetaxel-induced Stevens-Johnson syndrome with regenerating epidermis composed of atypical keratinocytes. (19453796)
2009
25
Stevens-Johnson syndrome due to prophylactic fluconazole in two patients with liver failure. (19548943)
2009
26
Stevens-Johnson syndrome induced by combination of imatinib and allopurinol. (19439939)
2009
27
HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese. (18385790)
2008
28
Human immunodeficiency virus-infected boy with Stevens-Johnson syndrome caused by nevirapine. (18458648)
2008
29
Mycoplasma pneumoniae infection with incomplete Stevens-Johnson syndrome. (18922478)
2008
30
Stevens-Johnson syndrome and toxic epidermal necrolysis induced by amifostine during head and neck radiotherapy. (18328585)
2008
31
Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. (17314152)
2007
32
Imatinib-induced Stevens-Johnson syndrome: recurrence after re-challenge with a lower dose. (17287945)
2007
33
Dexamethasone pulse therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis. (17340021)
2007
34
Stevens-Johnson syndrome in children receiving phenobarbital therapy and cranial radiotherapy. (17589805)
2007
35
Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006. (17713361)
2007
36
Immunohistochemical expression of apoptotic markers in drug-induced erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. (17880768)
2007
37
Stevens-Johnson syndrome from metronidazole. (16918620)
2006
38
Vesicular eczema after intravenous immunoglobulin therapy for treatment of Stevens-Johnson syndrome. (16490861)
2006
39
Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors. (16180941)
2005
40
Mycoplasma pneumoniae-induced Stevens-Johnson syndrome without skin lesions: fact or fiction? (15692479)
2005
41
Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome. (15878074)
2005
42
Dacryocystoceles in the aftermath of Stevens-Johnson syndrome. (15778676)
2005
43
Stevens-Johnson syndrome associated with azithromycin followed by transient reactivation of herpes simplex virus infection. (14674950)
2004
44
Medical genetics: a marker for Stevens-Johnson syndrome. (15057820)
2004
45
A prediction model to identify risk of developing Stevens-Johnson syndrome or toxic epidermal necrolysis in patients with erythema multiforme. (14968733)
2003
46
Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in northeastern Malaysia. (9679693)
1998
47
Spontaneous reports of drug-induced erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in Denmark 1968-1991. (15073835)
1996
48
Mycoplasma pneumoniae infection is associated with Stevens-Johnson syndrome, not erythema multiforme (von Hebra). (8912572)
1996
49
Erythema multiforme with mucous membrane involvement and Stevens-Johnson syndrome are clinically different disorders with distinct causes. (7741539)
1995
50
Orbital cyst in a patient with Stevens-Johnson syndrome. (1468225)
1992

Genetic Variations for Stevens-Johnson Syndrome

Expression for genes affiliated with Stevens-Johnson Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Stevens-Johnson Syndrome

Search GEO for disease gene expression data for Stevens-Johnson Syndrome.

Pathways for genes affiliated with Stevens-Johnson Syndrome

Sources:
54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Stevens-Johnson Syndrome

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1(glc)44510.6FAS, FASLG
2chromium4510.6FASLG, GNLY, GZMB
3concanamycin a45 6011.5GZMB, GNLY, FAS, FASLG
4ivig4510.5GZMB, FAS, FASLG
5atpo45 2911.5FASLG, FAS
6phosphatidylserine45 29 1112.5FASLG, FAS, GZMB, HSPG2
7c2ceramide4510.5HSPG2, FAS, FASLG
8tacrolimus45 50 1112.4CCL22, CCL17, GZMB, FASLG, HLA-B
9rottlerin4510.4HSPG2, FAS, FASLG
10pge24510.4HSPG2, CCL22, FASLG, HLA-B, F2RL2
11cyclosporin a45 29 6012.4CCL22, CCL17, GZMB, FAS, FASLG, HLA-B
12lactate4510.3F2RL2, HLA-B, FASLG, FAS, GZMB
13oligonucleotide4510.3CCL22, GZMB, GNLY, FAS, FASLG, HLA-B
14allopurinol45 50 1112.3TCF19, CCHCR1, PSORS1C1, PSORS1C3, PPIAP9, HLA-B
15nitric oxide45 11 2412.3CCL17, GZMB, FAS, FASLG, HLA-B, TGM1
16dexamethasone45 50 29 1113.3HSPG2, CCL22, CCL17, GZMB, FAS, FASLG
17cytarabine45 50 1112.3FASLG, FAS, GZMB
18fibrinogen4510.2CCL22, CCL17, HLA-B, F2RL2
19rantes4510.2CCL22, CCL17, GZMB, GNLY, FAS, FASLG
20retinoic acid45 2411.2HSPG2, GZMB, FAS, FASLG, HLA-B, TGM1
21ly2940024510.1HSPG2, GZMB, FAS, FASLG
22calcium45 50 11 2412.9CCL22, CCL17, GZMB, FASLG, HLA-B, F2RL2
23steroid459.8CCHCR1, GZMB, GNLY, HLA-B, TGM1

GO Terms for genes affiliated with Stevens-Johnson Syndrome

Sources:
16Gene Ontology
See all sources

Biological processes related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
2immune responseGO:00695510.2HLA-B, FASLG, CCL17, CCL22
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS

Molecular functions related to Stevens-Johnson Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.2FAS, KLRC2, KLRD1

Products for genes affiliated with Stevens-Johnson Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Stevens-Johnson Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet