SMS
MCID: STF001
MIFTS: 56

Stiff-Person Syndrome (SMS) malady

Categories: Rare diseases, Neuronal diseases, Endocrine diseases

Aliases & Classifications for Stiff-Person Syndrome

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 45NCIt, 48NIH Rare Diseases, 49NINDS, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Stiff-Person Syndrome:

Name: Stiff-Person Syndrome 52 11 49 39 13 68
Stiff Man Syndrome 11 48 54
Stiff Person Syndrome and Related Disorders 48 54
Moersch-Woltman Syndrome 48 54
Stiff-Man Syndrome 11 50
Sps 48 54
Sms 48 54
Progressive Encephalomyelitis with Rigidity and Myoclonus 54
Progressive Encephalomyelitis with Rigidity 68
 
Classic Stiff Person Syndrome 54
Focal Stiff-Person Syndrome 54
Focal Stiff Limb Syndrome 54
Morsch Woltman Syndrome 48
Stiff Person Syndrome 48
Stiff Leg Syndrome 54
Classic Sps 54
Perm 54

Characteristics:

Orphanet epidemiological data:

54
stiff man syndrome:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (United Kingdom),<1/1000000 (Tanzania, United Republic of); Age of onset: Adult; Age of death: normal life expectancy
progressive encephalomyelitis with rigidity and myoclonus:
Inheritance: Not applicable; Age of onset: Adult
classic stiff person syndrome:
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult,elderly
focal stiff-person syndrome:
Inheritance: Not applicable

HPO:

64
stiff-person syndrome:
Onset and clinical course: adult onset
Inheritance: sporadic

Classifications:



External Ids:

OMIM52 184850
Disease Ontology11 DOID:13366
ICD1030 G25.82
ICD9CM32 333.91
MeSH39 D016750
SNOMED-CT62 5217008
NCIt45 C85170
ICD10 via Orphanet31 G25.8, G04.8
UMLS via Orphanet69 C0085292

Summaries for Stiff-Person Syndrome

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OMIM:52 The stiff-person syndrome (SPS) is most often an adult-onset sporadic acquired disorder characterized by progressive... (184850) more...

MalaCards based summary: Stiff-Person Syndrome, also known as stiff man syndrome, is related to breast cancer and progressive encephalomyelitis with rigidity and myoclonus, and has symptoms including fever, muscle rigidity and opisthotonus. An important gene associated with Stiff-Person Syndrome is GAD2 (Glutamate Decarboxylase 2), and among its related pathways are Beta-alanine metabolism (TR) and beta-Alanine metabolism (KEGG). Affiliated tissues include thyroid, spinal cord and brain, and related mouse phenotypes are no phenotypic analysis and respiratory system.

NIH Rare Diseases:48 Stiff person syndrome (sps) is a rare neurological disorder with features of an autoimmune disease. symptoms may include muscle stiffness in the trunk and limbs, and heightened sensitivity to noise, touch, and emotional distress, which can set off muscle spasms. affected people may also have abnormal postures, such as being hunched over. sps affects twice as many women as men. it is frequently associated with other autoimmune diseases such as diabetes, thyroiditis, vitiligo, and pernicious anemia. the exact causes of sps is not known. treatment may involve high-dose diazepam, anti-convulsants, or intravenous immunoglobulin (ivig). last updated: 10/8/2014

NINDS:49 Stiff-person syndrome (SPS) is a rare neurological disorder with features of an autoimmune disease.  SPS is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli such as noise, touch, and emotional distress, which can set off muscle spasms.  Abnormal postures, often hunched over and stiffened, are characteristic of the disorder.  People with SPS can be too disabled to walk or move, or they are afraid to leave the house because street noises, such as the sound of a horn, can trigger spasms and falls.  SPS affects twice as many women as men.   It is frequently associated with other autoimmune diseases such as diabetes, thyroiditis, vitiligo, and pernicious anemia.  Scientists don’t yet understand what causes SPS, but research indicates that it is the result of an autoimmune response gone awry in the brain and spinal cord.  The disorder is often misdiagnosed as Parkinson’s disease, multiple sclerosis, fibromyalgia, psychosomatic illness, or anxiety and phobia.  A definitive diagnosis can be made with a blood test that measures the level of glutamic acid decarboxylase (GAD) antibodies in the blood.  People with SPS have elevated levels of GAD, an antibody that works against an enzyme involved in the synthesis of an important neurotransmitter in the brain.

Disease Ontology:11 A movement disease that is of unknown etiology characterized by progressive rigidity.

Wikipedia:71 Stiff person syndrome (SPS), also known as stiff man syndrome (SMS), is a rare neurologic disorder of... more...

Related Diseases for Stiff-Person Syndrome

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Diseases related to Stiff-Person Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer29.9GAD2, INS
2progressive encephalomyelitis with rigidity and myoclonus12.5
3sm-ahnmd12.0
4mental retardation, x-linked, snyder-robinson type11.7
5smith-magenis syndrome11.7
6systemic mastocytosis11.4
7hyperekplexia11.4
8hyperekplexia, hereditary 1, autosomal dominant or recessive11.3
9hyperekplexia 111.1
10corneal dystrophy, congenital stromal11.0
11extratemporal epilepsy11.0
12hand dermatosis11.0
13potocki-lupski syndrome10.8
14steatocystoma multiplex10.8
15singleton merten syndrome10.8
16surfactant metabolism dysfunction, pulmonary, 110.8
17surfactant metabolism dysfunction, pulmonary, 210.8
18small patella syndrome10.8
19paraneoplastic neurologic disorders10.8
20paraneoplastic syndromes10.8
21aneruptive fever10.8
22ventilation pneumonitis10.8
23farmer's lung10.8
24tularemia10.8
25absence of septum pellucidum10.8
26myxozoa10.4
27thymoma10.2
28ataxia10.2
29inhalation anthrax10.2GLRA1, GLRB
30cerebellar ataxia10.1
31deafness, autosomal recessive 2910.1GAD1, GAD2
32mastocytosis10.1
33mixed cerebral palsy10.1GAD1, GAD2
34acromegaly10.1
35morse-rawnsley-sargent syndrome10.0GLRA1, GPHN
36lipedematous scalp10.0AMPH, GAD1, GAD2
37lymphoproliferative syndrome 110.0GLRA1, GLRB, GPHN
38lymphoma10.0
39thyroiditis10.0
40neuronitis10.0
41pneumonia9.9
42lymphoproliferative syndrome9.9GLRA1, GLRB, GPHN
43chudley-mccullough syndrome9.9GAD1, INS
44phaeohyphomycosis9.9GAD1, GAD2
45celiac disease9.9
46myasthenia gravis9.9
47sleep apnea9.9
48respiratory failure9.9
49graves' disease9.9
50dermatitis9.9

Graphical network of the top 20 diseases related to Stiff-Person Syndrome:



Diseases related to stiff-person syndrome

Symptoms & Phenotypes for Stiff-Person Syndrome

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Symptoms by clinical synopsis from OMIM:

184850

Clinical features from OMIM:

184850

Human phenotypes related to Stiff-Person Syndrome:

 54 64 (show all 30)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 anxiety64 54 Very frequent (99-80%) HP:0000739
2 hyperhidrosis64 54 Very frequent (99-80%) HP:0000975
3 falls64 54 Very frequent (99-80%) HP:0002527
4 emg abnormality64 54 Very frequent (99-80%) HP:0003457
5 intermittent painful muscle spasms64 54 Very frequent (99-80%) HP:0011964
6 emotional lability64 54 Frequent (79-30%) HP:0000712
7 agoraphobia64 54 Frequent (79-30%) HP:0000756
8 rigidity64 54 Frequent (79-30%) HP:0002063
9 exaggerated startle response64 54 Frequent (79-30%) HP:0002267
10 difficulty walking64 54 Frequent (79-30%) HP:0002355
11 paraspinal muscle hypertrophy64 54 Frequent (79-30%) HP:0012894
12 autoimmune antibody positivity64 54 Frequent (79-30%) HP:0030057
13 diabetes mellitus64 54 Occasional (29-5%) HP:0000819
14 hypothyroidism64 54 Occasional (29-5%) HP:0000821
15 lumbar hyperlordosis64 54 Occasional (29-5%) HP:0002938
16 abnormality of the nervous system54 Excluded (0%)
17 depression64 HP:0000716
18 hypertension64 HP:0000822
19 vitiligo64 HP:0001045
20 hyperreflexia64 HP:0001347
21 tachycardia64 HP:0001649
22 anemia64 HP:0001903
23 fever64 HP:0001945
24 opisthotonus64 HP:0002179
25 frequent falls64 HP:0002359
26 autoimmunity64 HP:0002960
27 myoclonic spasms64 HP:0003739
28 axial muscle stiffness64 HP:0006921
29 proximal limb muscle stiffness64 HP:0007066
30 asymmetric limb muscle stiffness64 HP:0007156

UMLS symptoms related to Stiff-Person Syndrome:


fever, muscle rigidity, opisthotonus, hyperexplexia, increased sweating

MGI Mouse Phenotypes related to Stiff-Person Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.9GAD1, GAD2, GLRA1, INS, TH
2MP:00053888.2GAD1, GAD2, GLRA1, GPHN, TH
3MP:00028738.2GABARAP, GAD1, GAD2, GPHN, INS, TH
4MP:00053797.9AMPH, GAD1, GAD2, GLRA1, GLRB, INS
5MP:00053867.5AMPH, GAD1, GAD2, GLRA1, GLRB, GPHN
6MP:00107687.5AMPH, GAD1, GAD2, GLRA1, GLRB, GPHN
7MP:00036317.5AMPH, GAD1, GAD2, GLRA1, GLRB, GPHN

Drugs & Therapeutics for Stiff-Person Syndrome

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Drugs for Stiff-Person Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 21692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2AntibodiesPhase 2, Phase 16394
3ImmunoglobulinsPhase 2, Phase 16394
4Antirheumatic AgentsPhase 210956
5Antibodies, MonoclonalPhase 24039
6Rho(D) Immune GlobulinPhase 1326
7gamma-GlobulinsPhase 1326
8Immunoglobulins, IntravenousPhase 1333
9
Glycineapproved, nutraceutical, vet_approved23256-40-6750
Synonyms:
(1-13c)glycinato
(15N)Glycine
15527_RIEDEL
15527_SIAL
15743-44-9 (mono-potassium salt)
17829-66-2 (cobalt salt)
18875-39-3
2,2-dialkylglycines
2-Aminoacetate
2-Aminoacetic acid
2311-65-1
25718-94-9
29728-27-6 (monoammonium salt)
32817-15-5 (copper salt)
33226_RIEDEL
33226_SIAL
33242-26-1 (calcium salt)
35947-07-0 (calcium salt (2:1))
410225_SIAL
50046_FLUKA
50046_SIGMA
513-29-1 (sulfate (3:1))
52955-63-2
56-40-6
57678-19-0
6000-43-7 (hydrochloride)
6000-44-8 (mono-hydrochloride salt)
63183-41-5 (hydrochloride hydrogen carbonate)
71295-98-2 (phosphate (1:1))
7490-95-1 (hydrochloride (2:1)
7490-95-1 (hydrochloride (2:1))
7575-55-5
848646-45-7
87867-94-5
AB-131/40217813
AB1002628
AC1L19XW
AC1Q28JW
AC1Q53O0
AI3-04085
AKOS000119626
AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER
AR-1A0345
AR-1A0532
Acide aminoacetique
Acide aminoacetique [INN-French]
Acido aminoacetico
Acido aminoacetico [INN-Spanish]
Acidum aminoaceticum
Acidum aminoaceticum [INN-Latin]
Aciport
Amino-Acetate
Amino-Acetic acid
Aminoacetate
Aminoacetic acid
Aminoazijnzuur
Aminoessigsaeure
Aminoethanoate
Aminoethanoic acid
Amitone
B72BA06C-60E9-4A83-A24A-A2D7F465BB65
BPBio1_001222
Biomol-NT_000195
C00037
CCRIS 5915
CHEBI:15428
CHEBI:15705
CHEBI:16228
CHEMBL773
CID750
CPD-8569
Corilin
D00011
DB00145
EINECS 200-272-2
 
FEMA No. 3287
FT-0083159
G
G0099
G0317
G5417_SIGMA
G5523_SIGMA
G7126_SIGMA
G7403_SIGMA
G8790_SIGMA
G8898_SIGMA
GLY (IUPAC abbrev)
GLYCINE 1.5% IN PLASTIC CONTAINER
GLYCINE, ACS
Glicina
Glicina [INN-Spanish]
Glicoamin
Gly
Glycin
Glycine
Glycine (JP15/USP)
Glycine [INN]
Glycine iron sulphate (1:1)
Glycine, homopolymer (VAN)
Glycine, labeled with carbon-14
Glycine, non-medical
Glycine-UL-14C hydrochloride
Glycinum
Glycinum [INN-Latin]
Glycocoll
Glycolixir
Glycosthene
Glykokoll
Glyzin
Gyn-Hydralin
Gyn-hydralin
H-Gly-OH
H2N-CH2-COOH
HSDB 495
Hampshire glycine
Hgly
InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5
KST-1A2919
KST-1A8102
L-Glycine
L-alpha-amino acids
L001246
LS-218
Leimzucker
MolPort-000-871-607
NCGC00024503-01
NCGC00024503-02
NChemBio.2007.13-comp1
NSC 25936
NSC25936
P8791_SIGMA
Padil
Polyglycine II
S04-0135
Sucre de gelatine
Tocris-0219
UNII-TE7660XO1C
W328707_ALDRICH
WLN: Z1VQ
aminoacetic acid
an alpha amino acid ester
bmse000089
gly
glycine
nchem.554-comp2
nchembio.121-comp9
nchembio.145-comp33
nchembio.198-comp12
nchembio.265-comp9
nchembio.266-comp30
polyglycine
10Autoantibodies130
11Neurotransmitter Agents18340
12Glutamic AcidNutraceutical228

Interventional clinical trials:

idNameStatusNCT IDPhase
1Rituximab to Treat Stiff Person SyndromeCompletedNCT00091897Phase 2
2Stem Cell Transplantation for Stiff Person Syndrome (SPS)RecruitingNCT02282514Phase 1, Phase 2
3Intravenous Immunoglobulin (IVIg) for the Treatment of Stiff-Man Syndrome (SMS)CompletedNCT00001550Phase 1
4Cause, Development, and Progression of Stiff-Person SyndromeCompletedNCT00030940
5Effects of Mutations of the Glycine Gene Associated With Hyperekplexia on Central Pain ProcessingTerminatedNCT01476514

Search NIH Clinical Center for Stiff-Person Syndrome


Cochrane evidence based reviews: stiff-person syndrome

Genetic Tests for Stiff-Person Syndrome

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Anatomical Context for Stiff-Person Syndrome

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MalaCards organs/tissues related to Stiff-Person Syndrome:

36
Thyroid, Spinal cord, Brain, Testes, Breast, Eye, T cells

Publications for Stiff-Person Syndrome

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Articles related to Stiff-Person Syndrome:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Stiff person syndrome masquerading as multiple sclerosis. (28017232)
2017
2
Central Sleep Apnea and Stiff Person Syndrome: A Case Report. (28358591)
2017
3
Erratum: Serotonin-norepinephrine reuptake inhibitors may exacerbate stiff-person syndrome. (27761484)
2016
4
Stiff person syndrome and other immune-mediated movement disorders - new insights. (27262149)
2016
5
Utility of ultrasonography in evaluating muscle contractions in stiff-person syndrome. (27423620)
2016
6
Long-term efficacy of pregabalin in stiff person syndrome. (27527522)
2016
7
Rhabdomyolysis and Autoimmune Variant Stiff-Person Syndrome. (28028432)
2016
8
Lockjaw in stiff-person syndrome with autoantibodies against glycine receptors. (26767190)
2016
9
Stiff person syndrome in South Asia. (27756410)
2016
10
Anesthetic management of a parturient with Stiff person syndrome for urgent cesarean delivery. (27378710)
2016
11
Poster 360 Acute Rehabilitation of a Patient with Stiff Person Syndrome (SPS) and GAD-Antibody Cerebellar Ataxia: A Case Report. (27673113)
2016
12
Pediatric stiff-person syndrome with renal failure. (26933366)
2016
13
Poster 258 A Novel Approach to the Treatment of Stiff-Person-Syndrome with Botulinum Toxin: A Case Report. (27673015)
2016
14
A case report of patient with cerebellar variant of stiff person syndrome. (26851693)
2016
15
Anesthesia in a patient with Stiff Person Syndrome. (27591471)
2016
16
Multiple anesthetics for a patient with stiff-person syndrome. (27185709)
2016
17
Acute Respiratory Failure in a Patient with Stiff-Person Syndrome. (27430873)
2016
18
Poster 237 Bilateral Hip Fracture During Hospitalization for Spasm Exacerbation in an Adult with Stiff Person Syndrome: A Case Report. (27672995)
2016
19
Amphiphysin-positive paraneoplastic myelitis and stiff-person syndrome. (27734022)
2016
20
Serotonin-norepinephrine reuptake inhibitors may exacerbate stiff-person syndrome. (27606356)
2016
21
Stiff Person Syndrome with Pyramidal Signs. (28360797)
2016
22
A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody. (27011652)
2016
23
Ophthalmoplegia heralding the onset of anti-amphiphysin related paraneoplastic stiff person syndrome. (26946498)
2016
24
Clinical Spectrum of Stiff Person Syndrome: A Review of Recent Reports. (26989571)
2016
25
Stiff Person Syndrome Masquerading as Acute Coronary Syndrome. (27692358)
2016
26
Stiff-Person Syndrome and Graves' Disease: A Pediatric Case Report. (28503622)
2016
27
Anesthetic Considerations of Stiff-Person Syndrome: A Case Report. (27501653)
2016
28
Presynaptic neuromuscular transmission defect in the stiff person syndrome. (27905901)
2016
29
Paraneoplastic stiff person syndrome: Inpatient rehabilitation outcomes of a rare disease from two cancer rehabilitation programmes. (27157044)
2016
30
Gastrointestinal and Urologic Sphincter Dysfunction in Stiff Person Syndrome. (27861223)
2016
31
Familial case reports of stiff-person syndrome. (25912339)
2015
32
A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy. (26061327)
2015
33
Stiff Person Syndrome. (27604442)
2015
34
What's stiff-person syndrome? (26287715)
2015
35
Stiff-person syndrome with central sleep apnea after thymoma excision: report of the first known case. (26238984)
2015
36
Pearls & Oy-sters: Tonic eye deviation in stiff-person syndrome. (25917489)
2015
37
A Report of Stiff Person Syndrome in Tanzania with First Epidemiological Figures for Sub-Saharan Africa. (26316197)
2015
38
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome. (26080009)
2015
39
Role of osteopathic manipulative treatment in the management of stiff person syndrome. (26024334)
2015
40
Botulinum toxin a injection to facial and cervical paraspinal muscles in a patient with stiff person syndrome: a case report. (25459656)
2015
41
Stiff person syndrome: a tough and rigid case. (26040059)
2015
42
A Rare Case of Childhood Stiff Person Syndrome Associated With Pleuropulmonary Blastoma. (26344328)
2015
43
Are patients with truncal type of Stiff Person Syndrome hidden in a heterogenous group of non-radiographic axial spondyloarthritis? (26005769)
2015
44
Recent Advances and Review on Treatment of Stiff Person Syndrome in Adults and Pediatric Patients. (26848416)
2015
45
Therapeutic plasma exchange in two patients with stiff-person syndrome. (26407506)
2015
46
Focal gradual-onset variant of stiff-person syndrome. (25636820)
2015
47
Stiff Person Syndrome: A Rare Neurological Disorder, Heterogeneous in Clinical Presentation and Not Easy to Treat. (26106494)
2015
48
Stiff person-syndrome IgG affects presynaptic GABAergic release mechanisms. (24990310)
2014
49
Reducing excess stiffness in Stiff Person Syndrome using CBT: A case study. (25238861)
2014
50
Efficacy of therapeutic plasma exchange for treatment of stiff-person syndrome. (24527774)
2014

Variations for Stiff-Person Syndrome

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Expression for genes affiliated with Stiff-Person Syndrome

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Search GEO for disease gene expression data for Stiff-Person Syndrome.

Pathways for genes affiliated with Stiff-Person Syndrome

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GO Terms for genes affiliated with Stiff-Person Syndrome

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Cellular components related to Stiff-Person Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:006120210.5GAD1, GAD2
2chloride channel complexGO:003470710.3GLRA1, GLRB
3inhibitory synapseGO:006007710.1GAD1, GAD2, GLRA1
4postsynaptic membraneGO:00452119.8GLRA1, GLRB, GPHN
5axonGO:00304249.7GAD1, GAD2, TH
6synaptic vesicle membraneGO:00306729.7AMPH, GAD2
7smooth endoplasmic reticulumGO:00057909.7GABARAP, TH
8cell junctionGO:00300549.1AMPH, GAD2, GLRA1, GLRB, GPHN
9dendriteGO:00304259.0GLRA1, GLRB, GPHN, TH
10cytoplasmic vesicleGO:00314109.0AMPH, GABARAP, GAD2, TH
11synapseGO:00452028.5AMPH, GAD1, GAD2, GLRA1, GLRB, GPHN

Biological processes related to Stiff-Person Syndrome according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1carboxylic acid metabolic processGO:001975210.5GAD1, GAD2
2glutamate decarboxylation to succinateGO:000654010.5GAD1, GAD2
3neurotransmitter secretionGO:000726910.5GAD1, GAD2
4acrosome reactionGO:000734010.3GLRA1, GLRB
5adult walking behaviorGO:000762810.3GLRA1, GLRB
6neuromuscular processGO:005090510.3GLRA1, GLRB
7gamma-aminobutyric acid receptor clusteringGO:009711210.2GLRB, GPHN
8righting reflexGO:006001310.2GLRA1, GLRB
9startle responseGO:000196410.2GLRA1, GLRB
10synaptic transmission, glycinergicGO:006001210.2GLRA1, GLRB
11social behaviorGO:00351769.9GAD1, TH
12response to metal ionGO:00100389.9GPHN, TH
13neurotransmitter biosynthetic processGO:00421369.7GAD1, GAD2, TH
14response to drugGO:00424939.6GAD1, GAD2, TH
15visual perceptionGO:00076018.8GLRA1, GLRB, TH
16chemical synaptic transmissionGO:00072688.5AMPH, GABARAP, GAD1, GAD2, GLRA1, GLRB

Molecular functions related to Stiff-Person Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1carboxy-lyase activityGO:001683110.6GAD1, GAD2
2glutamate bindingGO:001659510.6GAD1, GAD2
3glutamate decarboxylase activityGO:000435110.6GAD1, GAD2
4extracellular ligand-gated ion channel activityGO:000523010.4GLRA1, GLRB
5extracellular-glycine-gated chloride channel activityGO:001693410.4GLRA1, GLRB
6extracellular-glycine-gated ion channel activityGO:001693310.4GLRA1, GLRB
7glycine bindingGO:001659410.4GLRA1, GLRB
8pyridoxal phosphate bindingGO:00301709.8GAD1, GAD2
9protein bindingGO:00055156.5AMPH, GABARAP, GAD1, GAD2, GLRA1, GLRB

Sources for Stiff-Person Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet