MCID: STM004
MIFTS: 65

Stomach Cancer malady

Cancer diseases, Gastrointestinal diseases categories

Summaries for Stomach Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The stomach is an organ between the esophagus and the small intestine. it mixes food with stomach acid and helps digest protein. stomach cancer mostly affects older people - two-thirds of people who have it are over age 65. your risk of getting it is also higher if you have had a helicobacter pylori infection have had stomach inflammation are a man eat lots of salted, smoked, or pickled foods smoke cigarettes have a family history of stomach cancer it is hard to diagnose stomach cancer in its early stages. indigestion and stomach discomfort can be symptoms of early cancer, but other problems can cause the same symptoms. in advanced cases, there may be blood in your stool, vomiting, unexplained weight loss, jaundice, or trouble swallowing. doctors diagnose stomach cancer with a physical exam, blood and imaging tests, an endoscopy, and a biopsy. because it is often found late, it can be hard to treat stomach cancer. treatment options include surgery, chemotherapy, radiation or a combination. nih: national cancer institute

MalaCards: Stomach Cancer, also known as stomach carcinoma, is related to adenocarcinoma and pancreatic cancer. An important gene associated with Stomach Cancer is MUTYH (mutY homolog). The drugs cisplatin and cisplatin pwdr have been mentioned in the context of this disorder. Affiliated tissues include the stomach, testes and small intestine.

Disease Ontology:8 A gastrointestinal system cancer that is located in the stomach.

Wikipedia:63 Stomach cancer, or gastric cancer, refers to cancer arising from any part of the stomach. Stomach cancer... more...

Description from OMIM:46 613659,137215

Aliases & Classifications for Stomach Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

stomach cancer 8 42 10 33
stomach carcinoma 8 42 60
malignant tumor of greater curve of stomach 8 60
malignant tumor of lesser curve of stomach 8 60
malignant neoplasm of body of stomach 8 60
cancer of the stomach 8 22
gastric carcinoma 8 44
malignant neoplasm of greater curvature of stomach, unspecified 8
malignant neoplasm of lesser curvature of stomach, unspecified 8
malignant neoplasm of greater curve of stomach unspecified 8
malignant neoplasm of lesser curve of stomach unspecified 8
malignant neoplasm of greater curvature of stomach, nos 8
malignant neoplasm of lesser curvature of stomach, nos 8
malignant tumor of body of stomach 8
ca greater curvature of stomach 8
ca greater curvature - stomach 8
ca lesser curvature of stomach 8
ca lesser curvature - stomach 8
malignant neoplasm of stomach 60
adult stomach carcinoma 42
adult stomach cancer 42
carcinoma of stomach 8
neoplasm of stomach 8
ca body - stomach 8
stomach neoplasms 60
stomach neoplasm 8
gastric neoplasm 8
gastric cancer 44


Related Diseases for Stomach Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Stomach Cancer family:

Stomach Carcinoma in Situ Stomach Cancer, Familial

Diseases related to Stomach Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 313)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.2CCKBR, PSCA, CEACAM7
2pancreatic cancer29.9CEACAM7, PSCA, CCKBR
3melanoma29.8CEACAM7, CD70, MAGEA10
4stomach disease10.5
5in situ carcinoma10.5
6breast cancer10.4
7esophageal cancer10.4
8esophagitis10.4
9gastritis10.4
10lung cancer10.4
11disseminated intravascular coagulation10.4
12atrophic gastritis10.3
13colon cancer10.3
14colorectal cancer10.3
15neuroendocrine carcinoma10.3
16lymphoepithelioma-like carcinoma10.3
17retinoblastoma10.3
18cronkhite-canada syndrome10.3
19microinvasive gastric cancer10.3
20situs inversus10.3
21ataxia telangiectasia10.2
22signet ring cell adenocarcinoma10.2
23gastric signet ring cell adenocarcinoma10.2
24li-fraumeni syndrome10.2
25connective tissue cancer10.2
26spleen cancer10.2
27cell type cancer10.2
28gastric adenocarcinoma10.2
29leukemia10.2
30lymph node cancer10.2
31ovarian cancer10.2
32lynch syndrome10.2
33bone carcinoma10.2
34pyloric stenosis10.2
35xeroderma pigmentosum10.2
36intestinal obstruction10.2
37thyroid cancer10.2
38thyroiditis10.2
39gastric ulcer10.2
40pernicious anemia10.2
41peritonitis10.2
42stomach cancer, childhood10.2
43stomach cancer, familial10.2
44small cell carcinoma10.1
45cicatricial pemphigoid10.1
46glomerulonephritis10.1
47gastric tubular adenocarcinoma10.1
48dumping syndrome10.1
49tubular adenocarcinoma10.1
50embryonal cancer10.1

Graphical network of the top 20 diseases related to Stomach Cancer:



Diseases related to stomach cancer

Clinical Features for Stomach Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

613659,137215

Drugs & Therapeutics for Stomach Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stomach Cancer

Drug clinical trials:

Search ClinicalTrials for Stomach Cancer

Search NIH Clinical Center for Stomach Cancer

Search CenterWatch for Stomach Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Stomach Cancer

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Sources:
22GTR
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Genetic tests related to Stomach Cancer:

id Genetic test Affiliating Genes
1 Neoplasm of Stomach22

Anatomical Context for Stomach Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Stomach Cancer:

32
Testes, Small intestine, Breast, Colon, Lung, Liver, Lymph node, Bone, Pancreas, Prostate, Bone marrow, Kidney, Endothelial, Thyroid, Heart, Brain, Cervix

FMA organs/tissues related to Stomach Cancer:

14
The stomach

Animal Models for Stomach Cancer or affiliated genes

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Publications for Stomach Cancer

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Sources:
50PubMed
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Articles related to Stomach Cancer:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Identification of transporters associated with Etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics. (23197647)
2013
2
Cancer in MA8ori: lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand. (23279256)
2013
3
Time characteristics of the effect of alcohol cessation on the risk of stomach cancer--a meta-analysis. (23786883)
2013
4
Can salt hypothesis explain the trends of mortality from stroke and stomach cancer in Western europe? (22783462)
2012
5
Bioactive hyaluronan fragment (hexasaccharide) detects specific hexa-binding proteins in human breast and stomach cancer: possible role in tumorogenesis. (23077783)
2012
6
Stomach cancer and myositis ossificans-like lesions. (21444872)
2011
7
Prognostic factors and survival in stomach cancer - analysis of 15 years of data from a referral hospital in iran and evaluation of international variation. (21447975)
2011
8
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males. (21133627)
2010
9
Preliminary experience using high intensity focused ultrasound for treating liver metastasis from colon and stomach cancer. (19212862)
2009
10
Lactococcus lactis ssp. lactis inhibits the proliferation of SNU-1 human stomach cancer cells through induction of G0/G1 cell cycle arrest and apoptosis via p53 and p21 expression. (19723065)
2009
11
A rare case of breast cancer metastasis presenting as linitis plastica of the stomach and colon (with videos). (19699983)
2009
12
Analysis of NM23 protein and components of plasminogen activation system in tumors of patients with stomach cancer with consideration for disease clinical picture and morphology. (19513384)
2008
13
Personal background and cognitive factors as predictors of the intention to be screened for stomach cancer. (18768518)
2008
14
The effects of blood motilin and gastrin on electrical activity and emptying of the intrathoracic stomach after esophagectomy for cancer]. (18036299)
2007
15
CT and PET in stomach cancer: preoperative staging and monitoring of response to therapy. (16418249)
2006
16
A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer]. (15231125)
2004
17
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population. (15222046)
2004
18
JAMA patient page. Stomach cancer. (14722154)
2004
19
Mutation of FADD gene is rare in human colon and stomach cancers. (15601308)
2004
20
Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer. (14998859)
2004
21
New approaches to therapy of cancers of the stomach, colon and pancreas based on peptide analogs. (15112052)
2004
22
Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. (15280918)
2004
23
A population-based dietary intervention trial in a high-risk area for stomach cancer and stroke: changes in intakes and related biomarkers. (14572428)
2003
24
Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. (12066204)
2002
25
Prospective study of educational background and stomach cancer in Japan. (12200096)
2002
26
Stomach cancer and occupation in Sweden: 1971-89. (11983848)
2002
27
A prospective correlation of LaurAcn's histological classification of stomach cancer with clinicopathological findings including DNA flow cytometry. (11358006)
2001
28
Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas. (11278335)
2001
29
A nested case-control study of stomach cancer mortality among automobile machinists exposed to metalworking fluid. (11018429)
2000
30
Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines. (11032918)
2000
31
Expression of hyaluronan receptors CD44 and RHAMM in stomach cancers: relevance with tumor progression. (11029494)
2000
32
The epidemiology of stomach cancer: correlating the past with the present. Socioeconomic influences in early life can influence mortality in adult life. (10864523)
2000
33
Helicobacter pylori infection on the risk of stomach cancer and chronic atrophic gastritis. (10468887)
1999
34
Circumvention of 5-fluorouracil resistance in human stomach cancer cells by uracil phosphoribosyltransferase gene transduction. (10359051)
1999
35
Prospective, double-blind, placebo-controlled randomized trial of cimetidine in gastric cancer. British Stomach Cancer Group. (10604733)
1999
36
Unique sequence of pernicious anemia, stomach cancer, and myelodysplastic syndrome. (10589088)
1999
37
Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells. (9852288)
1998
38
Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells. (9870185)
1998
39
Diet/nutrition and stomach cancer in Japan. (9209018)
1997
40
Antioxidant vitamins and stomach cancer: the role of ecologic studies. (9103324)
1997
41
Immunohistochemical detection of K-sam protein in stomach cancer. (9816310)
1996
42
Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. (8671549)
1996
43
Identification of novel genes from stomach cancer cell lines by differential display. (7750094)
1995
44
Factors influencing growth rate of recurrent stomach cancers as determined by analysis of serum carcinoembryonic antigen. (7889481)
1995
45
Combination chemotherapy with epirubicin, cisplatin and 5-fluorouracil for the palliation of advanced gastric and oesophageal adenocarcinoma. The MRC Gastric Cancer Working Party and the British Stomach Cancer Group. (7542143)
1995
46
Alcohol and the risk of cancers of the stomach and colon-rectum. (7882548)
1994
47
Comparison of c-erbB-2 oncoprotein expression in tissue and serum of patients with stomach cancer. (7991990)
1994
48
Mortality from asthma, chronic obstructive pulmonary disease, respiratory system cancer, and stomach cancer among paper mill workers: a case-referent study. (1882851)
1991
49
The use of ceruloplasmin in combination with adjuvant polychemotherapy in stomach cancer]. (2042339)
1991
50
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. (3041593)
1988

Genetic Variations for Stomach Cancer

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Expression for genes affiliated with Stomach Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stomach Cancer

Search GEO for disease gene expression data for Stomach Cancer.

Pathways for genes affiliated with Stomach Cancer

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Compounds for genes affiliated with Stomach Cancer

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GO Terms for genes affiliated with Stomach Cancer

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16Gene Ontology
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Biological processes related to Stomach Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.7PGA5, PGC, CCKBR

Molecular functions related to Stomach Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aspartic-type endopeptidase activityGO:00419010.6PGA5, PGC

Products for genes affiliated with Stomach Cancer

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  • Antibodies
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Sources for Stomach Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet