Stomach Cancer malady

Disease Ontology: A gastrointestinal system cancer that is located in the stomach.⁶

MalaCards: Stomach Cancer, also known as malignant neoplasm of body of stomach, is related to stomach carcinoma and salivary gland cancer. An important gene associated with Stomach Cancer is PTPRH (protein tyrosine phosphatase, receptor type, H), and among its related pathways are Pancreatic cancer and Cell adhesion PLAU signaling. The drugs prednisone and prednisolone tebutate and the compounds cytosine and nadph have been mentioned in the context of this disorder. Affiliated tissues include the stomach, bone marrow and small intestine, and related mouse phenotypes are craniofacial and respiratory system.

Aliases & Descriptions:

stomach cancer 6 malignant neoplasm of body of stomach 6 43 malignant neoplasm of greater curve of stomach unspecified (disorder) 6 malignant neoplasm of lesser curve of stomach unspecified (disorder) 6 malignant neoplasm of greater curvature of stomach, unspecified 6 malignant neoplasm of lesser curvature of stomach, unspecified 6 malignant neoplasm of greater curvature of stomach, nos 6 malignant tumor of greater curve of stomach (disorder) 6 malignant neoplasm of lesser curvature of stomach, nos 6 malignant tumor of lesser curve of stomach (disorder) 6 malignant tumor of body of stomach (disorder) 6 malignant tumor of greater curve of stomach 43 malignant tumor of lesser curve of stomach 43

ca greater curvature - stomach (disorder) 6 ca lesser curvature - stomach (disorder) 6 ca greater curvature of stomach 6 ca lesser curvature of stomach 6 neoplasm of stomach (disorder) 6 malignant neoplasm of stomach 43 ca body - stomach (disorder) 6 malignant neoplasms 43 stomach neoplasms 43 ca body - stomach 6 stomach neoplasm 6 gastric neoplasm 6 neoplasms 43

Diseases related to stomach cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1527)

id	Related Disease	Score	Top Affiliating Genes
1	stomach carcinoma	33.8	CHGA, CEACAM5, CD44, CDH1, MLH1, FAS
2	salivary gland cancer	32.9	CHUK, CFLAR, MMP9, MET, FAS, CASP3
3	alcoholism	32.1	CCKBR, GPT, HTR3A, ALDH2, GLUD1, CYP2E1
4	nasopharynx carcinoma	32.0	KLF6, PCNA, NAT2, BCL2, BAX, XRCC1
5	pancreatic ductal carcinoma	31.7	CHGA, MUC2, MUC5AC, MUC6, FASLG, KRT8
6	ovarian cancer	31.2	BRCA1, CEACAM3, ERBB2, KRAS, SLC2A1, NME1
7	oral cavity cancer	30.7	NAT2, VEGFA, BAX, GSTM1, GSTT1, IL18
8	rectum cancer	30.5	BAX, CEACAM5, CEACAM3, MMP7, HBEGF, TYMP
9	breast cancer	30.1	BRCA1, BRCA2, MYC, BMP6, CDH1, FGF4
10	tongue cancer	29.9	PCNA, VEGFA, MYC, BCL2, BAX, CDKN1A
11	cardia cancer	29.8	MTRR, MTHFR, XRCC1, CD44, GSTM1, GSTP1
12	intestinal neoplasm	29.8	BRAF, BMP6, MMP2, MMP9, APC, PTGS2
13	intraepithelial neoplasm	29.7	PCNA, BMP6, MUC1, MUC2, MUC5AC, MUC6
14	colonic neoplasm	29.7	BCL2, CDKN1A, CD44, CDH1, INS, TP53
15	bronchogenic carcinoma	29.7	CEACAM5, CEACAM7, CDKN1A, GSTM3, IL10, TP53
16	parathyroid carcinoma	29.6	RB1, BRCA2, MKI67, CCND1, TP53, TERT
17	myoma	29.5	PCNA, XRCC4, CCND1, TERT, PTGS2, KRAS
18	pancreatic cancer	29.5	BRCA2, VEGFA, CHGA, MUC1, MUC2, MUC5AC
19	kidney cancer	29.4	BRAF, VEGFA, CD44, GSTP1, MET, ANPEP
20	thoracic cancer	29.4	CDKN1A, CASP3, CASP8, CASP9, PTGS2, SLC2A1
21	male breast cancer	29.2	PCNA, BRCA1, BRCA2, MYC, ERBB2
22	hepatitis	29.1	SELP, FASLG, FAS, GPT, GLUD1, TXN
23	squamous cell carcinoma	29.1	CD44, CDH1, MMP7, MKI67, GSTP1, CCND1
24	neuroendocrine tumor	29.1	CHGA, CEACAM3, CDX2, MKI67, CCKBR, SRC
25	gastric cancer, somatic	29.1	KLF6, MUTYH, IRF1, FGFR2, APC, CASP10
26	malignant peripheral nerve sheath tumor	29.0	MUC1, S100A6, MET, TERT, NOS2, ABCB1
27	myelodysplastic syndrome	28.9	CFLAR, IRF1, GSTM1, GSTT1, IL1A, FASLG
28	fallopian tube carcinoma	28.8	BRCA1, BRCA2, MYC, MKI67, ERBB2, TP53
29	anaplastic carcinoma	28.7	BRAF, MUC1, S100A6, CEACAM3, CDH1, KRT8
30	skin benign neoplasm	28.7	BRAF, XPC, JUN, MLH1, MGMT, MAPK1
31	basal cell carcinoma	28.6	BCL2, BAX, XRCC1, XRCC3, CD44, MKI67
32	diffuse gastric cancer	28.6	MTR, XRCC3, CDH1, GSTM1, GSTP1, GSTT1
33	gastric adenocarcinoma	28.5	NAT1, NAT2, MYC, BCL2, CHGA, MUC2
34	cervix carcinoma	28.5	NBN, MYC, CDKN1A, CD44, MKI67, MET
35	brain cancer	28.3	KLF6, RB1, NAT2, VEGFA, RAD51, CDKN1A
36	gastrointestinal stromal tumor	28.2	NAT2, CDX2, APC, PTGS2, CTNNB1
37	lynch syndrome	28.2	BRCA1, BRCA2, BAX, MLH1, HRAS, TP53
38	mesenchymal cell neoplasm	28.1	PCNA, CD44, CCND1, IGF1, CASP3, HRAS
39	gastritis	27.9	S100A8, CDX2, MLH1, MGMT, GSTT1, IL8
40	familial pancreatic cancer	27.5	BRAF, BRCA1, BRCA2, ERBB2, TP53, KRAS
41	non-hodgkin lymphoma	27.5	NBN, NAT1, NAT2, MYC, BCL2, CHUK
42	pancreatic islet cell tumors	27.4	CHGA, CEACAM3, MMP2, MMP9, INS, CCKBR
43	ovarian mucinous neoplasm	27.3	PCNA, RB1, BRAF, MYC, CHGA, MUC1
44	adenoid cystic carcinoma	27.3	PCNA, MUC1, CEACAM3, CDH1, MKI67, CCND1
45	prostate carcinoma	27.2	KLF6, NBN, NAT2, BRCA2, VEGFA, BMP6
46	urinary bladder cancer	27.1	RB1, NAT1, NAT2, MUC2, CDKN1A, CDH2
47	familial colorectal cancer	27.1	BRAF, BCL2, MUTYH, CDH1, MLH1, MGMT
48	large cell carcinoma	27.0	BCL2, CHGA, BAX, CEACAM3, IGF2, IGF1
49	synovial sarcoma	26.9	BCL2, MUC1, CDH1, MKI67, MET, IGF2
50	t-cell leukemia	26.8	MYC, BCL2, CHUK, JUN, IL18R1, IL1A

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cisplatin, cisplatin pwdr [va product], dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], docetaxel, floxuridine, fluorouracil, ifosfamide, irinotecan, irinotecan hydrochloride, linolenic acid, methotrexate, methotrexate sodium, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to stomach cancer:

²²

FMA organs/tissues related to stomach cancer:

¹¹

MGI Mouse Phenotypes related to stomach cancer:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.6	REV3L, NBN, LIG4, LIG3, XRCC4, FGFR2
2	respiratory system phenotype	MP:0005388	10.6	SELP, BRCA1, DOK1
3	endocrine/exocrine gland phenotype	MP:0005379	10.2	KISS1, BUB1, NBN, BRCA1, BRCA2, XRCC4
4	embryogenesis phenotype	MP:0005380	9.6	KLF6, REV3L, NBN, NAT1, BRAF, BRCA1
5	liver/biliary system phenotype	MP:0005370	9.5	KLF6, BUB1, VEGFA, LIG4, LIG1, BCAR1
6	pigmentation phenotype	MP:0001186	9.0	RB1, BRAF, BRCA1, MYC, BCL2, FGFR2
7	hematopoietic system phenotype	MP:0005397	9.0	KLF6, REV1, REV3L, PCNA, BUB1, NBN
8	renal/urinary system phenotype	MP:0005367	9.0	KISS1, SELP, BRAF, BRCA1, BCL2, CHGA
9	immune system phenotype	MP:0005387	8.8	REV1, REV3L, SGCB, BUB1, NBN, SELP
10	limbs/digits/tail phenotype	MP:0005371	8.6	RB1, BRCA1, BRCA2, VEGFA, CHUK, BAX
11	normal phenotype	MP:0002873	8.3	KLF3, REV1, BUB1, NAT1, BRAF, BRCA1
12	integument phenotype	MP:0010771	8.0	KLF6, KISS1, RB1, SELP, BRAF, BRCA1
13	mortality/aging	MP:0010768	8.0	KLF3, KLF6, REV1, REV3L, KISS1, RB1
14	nervous system phenotype	MP:0003631	7.5	REV3L, KISS1, RB1, NBN, SELP, BRAF
15	behavior/neurological phenotype	MP:0005386	7.4	RB1, NBN, SELP, BRAF, BRCA2, LIG4
16	digestive/alimentary phenotype	MP:0005381	7.2	KISS1, RB1, BRAF, BRCA1, BRCA2, VEGFA
17	no phenotypic analysis	MP:0003012	7.2	PCNA, BUB1, RB1, VEGFA, MYC, MUC1
18	reproductive system phenotype	MP:0005389	6.7	KLF6, KISS1, BUB1, NBN, NAT1, BRCA1
19	growth/size phenotype	MP:0005378	6.5	KLF3, KLF6, REV1, REV3L, SGCB, KISS1
20	adipose tissue phenotype	MP:0005375	6.4	KLF3, RB1, SERPINE1, BRAF, BRCA1, MYC
21	skeleton phenotype	MP:0005390	6.0	RB1, BRAF, BRCA1, BRCA2, VEGFA, MYC
22	muscle phenotype	MP:0005369	5.0	SGCB, RB1, BRAF, BRCA1, VEGFA, MYC
23	tumorigenesis	MP:0002006	4.7	REV3L, BUB1, RB1, NBN, SERPINE1, BRAF
24	vision/eye phenotype	MP:0005391	4.7	RB1, SELP, NAT1, BRAF, VEGFA, BCL2
25	cellular phenotype	MP:0005384	3.3	KLF3, KLF6, REV1, REV3L, PCNA, BUB1
26	cardiovascular system phenotype	MP:0005385	2.6	KLF6, REV3L, SGCB, RB1, SELP, SERPINE1
27	homeostasis/metabolism phenotype	MP:0005376	2.0	REV3L, KISS1, BUB1, RB1, SELP, SERPINE1

Articles related to stomach cancer:

(show top 50)    (show all 131)

id	Title	Authors	Year	Affiliating Genes
1	Association between insulin-like growth factor-1 poly morphisms and stomach cancer risk in a Japanese population. (21854509)	Ennishi D.... Matsuo K.	2011	IGF1
2	Association of CASP3 and CASP9 polymorphisms with ge netic susceptibility to stomach cancer]. (21644232)	Ni Q.... Chen K.	2011	CASP3, CASP9
3	Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in hum an stomach cancer cells. (19857042)	Meng C.F.... Dai D.Q.	2010	MGMT
4	A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. (19924550)	Jia Y.... Ye W.	2010	MUC1, MUC6, MUC5AC
5	Beta-sitosterol inhibits cell growth and induces apop tosis in SGC-7901 human stomach cancer cells. (19456133)	Zhao Y.... Cui H.	2009	BAX
6	Lactococcus lactis ssp. lactis inhibits the prolifera tion of SNU-1 human stomach cancer cells through induction of G0/G1 cell cycle arrest and apoptosis via p53 and p21 expression. (19723065)	Kim S.Y.... Lee H.J.	2009	RB1, TP53, CCND1
7	Overexpression of phospholipase D suppresses taxotere-induced cell death in stomach cancer cells. (18190795)	Cho J.H.... Han J.S.	2008	PLD2
8	Analysis of NM23 protein and components of plasminoge n activation system in tumors of patients with stomach cancer with consideratio n for disease clinical picture and morphology. (19513384)	Kushlinskii N.E.... Stilidi I.S.	2008	PLAU, PLAT, SERPINE1
9	Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG 2. Safety of different selenium resources for prevention of stomach cancer (18421875)	Yang W.... Chen X.	2008	SLC17A5
10	Genetic polymorphisms in folate metabolism and the risk of stomach cancer. (17220339)	Zhang F.F.... Chow W.H.	2007	MTR, MTHFR, MTRR
11	How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population. (17854661)	Dundar M.... Ozkul Y.	2007	APC
12	Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer. (17438654)	Mu L.N.... Cai L.	2007	MTHFR
13	Pharmacogenetics and stomach cancer: an update. (17465714)	Toffoli G.... Cecchin E.	2007	TYMS
14	Mannose-binding lectin-2 genetic variation and stomach cancer risk. (16721783)	Baccarelli A.... Chow W.H.	2006	IL1B, MBL2
15	Hepatocyte growth factor/c-met signaling in regulating urokinase plasminogen activator in human stomach cancer: A potential therapeutic target for human stomach cancer. (16646560)	Lee K.H.... Kim J.R.	2006	MET, PLAU
16	Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines. (16520550)	Lee K.H.... Kim J.R.	2006	MET, MAP2K1, PLAU
17	Polymorphism in the 3'-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy. (16424979)	Lu J.W.... Feng J.F.	2006	TYMS
18	Genetic status of p53 in stomach cancer: somatic mutations and polymorphism of codon 72. (16984108)	Belyavskaya V.A.... Voevoda M.I.	2006	TP53
19	Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study. (16101328)	Yatsuya H.... Yoshimura T.	2005	TGFB1
20	Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population. (16158971)	Kim J.K.... Kim N.K.	2005	MTHFR
21	Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population. (15222046)	Shi W.X.... Chen S.Q.	2004	CYP2C19
22	The differential proteome profile of stomach cancer: identification of the biomarker candidates. (15559763)	Jang J.S.... Kim H.W.	2004	PDXK, PRDX4, NNMT
23	Glut1 expression and its relation with the absorption of 18F-FDG in stomach cancer (15312513)	Wei B.... Li R.	2004	SLC2A1
24	Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer. (14696128)	Chen S.Y.... Chen C.J.	2004	GSTT1, GSTM1, CYP2E1
25	Mutation of FADD gene is rare in human colon and stomach cancers. (15601308)	Soung Y.H.... Lee S.H.	2004	FADD
26	Increased expression of FLIP, an inhibitor of Fas-mediated apoptosis, in stomach cancer. (12716387)	Lee S.H.... Yoo N.J.	2003	FAS, CFLAR
27	Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma. (12879010)	Nagano H.... Hayashi Y.	2003	PTPRH, PTPMT1
28	CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer. (12209998)	Pharoah P.D.... Huntsman D.	2002	CDH1
29	Polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of stomach cancer (12411076)	Gao C.... Kazuo T.	2002	MTHFR
30	Stomach cancer highly expresses both initiator and effector caspases; an immunohistochemical study. (12588423)	Yoo N.J.... Lee S.H.	2002	CASP3, CASP10, CASP8
31	Immunoreactivity of CD99 in stomach cancer. (12172043)	Jung K.C.... Park S.H.	2002	CD99
32	Detection of cancer cells in peripheral blood of stomach cancer patients using RT-PCR amplification of tumour-specific mRNAs. (11966534)	Shin J.H.... Yang H.K.	2002	MET
33	5-Fluorouracil inhibits nitric oxide production through the inactivation of IkappaB kinase in stomach cancer cells. (12417257)	Jung I.D.... Lee H.Y.	2002	CHUK
34	Src/ERK but not phospholipase D is involved in keratinocyte growth factor-stimulated secretion of matrix metalloprotease-9 and urokinase-type plasminogen activator in SNU-16 human stomach cancer cell. (12458339)	Shin E.Y.... Kim E.G.	2002	SRC, PLAU, MAPK1
35	DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. (11146446)	Kanai Y.... Hirohashi S.	2001	DNMT3B, DNMT1
36	Molecular mechanism of carcinogenesis in human stomach cancer: Bub1 gene (11424422)	Inaba T.... Terashima M.	2001	BUB1
37	Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland. (11692073)	Lan Q.... Rothman N.	2001	GSTP1, GSTT1, GSTM3
38	Molecular aspects of invasion and metastasis of stomach cancer. (11217448)	Tahara E.	2000	CDH1, TERT, IL8
39	Expression of hyaluronan receptors CD44 and RHAMM in stomach cancers: relevance with tumor progression. (11029494)	Li H.... Liu J.	2000	CD44, HMMR
40	Frequent expression of soluble Fas and Fas ligand in Chinese stomach cancer and its preneoplastic lesions. (10762649)	Li H.... Liu J.	2000	FAS, FASLG
41	Inhibition of human stomach cancer metastasis in vivo by anti-P-selectin monoclonal antibody (10923507)	Chen J.... Chu Y.	1998	SELP
42	Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells. (9870185)	Sinha P.... Lage H.	1998	ANXA1, TXN
43	Enhanced expression of cytochrome P450 in stomach cancer. (9569036)	Murray G.I.... Melvin W.T.	1998	CYP2A6, CYP3A4, CYP2E1
44	Capsaicin can alter the expression of tumor forming-related genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1. (9461043)	Kim J.D.... Han I.S.	1997	MYC
45	Concentration and distribution of tumor associated antigens TAG-72 and CEA in stomach cancer. (7779533)	Chung J.K.... Koh C.S.	1995	CEACAM7
46	Molecular biology and immunohistochemical studies of Her2/neu oncogene in stomach cancer (7912666)	JAohne J.... Pichlmayr R.	1994	ERBB2
47	The mechanism of c-erbB-2 gene product increase in stomach cancer cell lines. (8104420)	Bae C.D.... Park J.B.	1993	ERBB2
48	The use of ceruloplasmin in combination with adjuvant polychemotherapy in stomach cancer (2042339)	Shchepotin I.B.... Iaremenko L.I.a.	1991	CP
49	The dynamics of the enzymatic activity of DNA metabolism during the treatment of stomach cancer patients (2275143)	Borzenko B.G.... Efimova I.A.	1990	TYMP
50	Do immunologic markers facilitate differentiation between histologic types of stomach cancer? (1693999)	JAohne J.... Pichlmayr R.	1990	ANPEP, KRT8, SI

Genes related to stomach cancer according to GeneCards:

(show top 50)    (show all 195)

id	Symbol	Description	Score	GeneCards Section Context
1	PTPRH	protein tyrosine phosphatase, receptor type, H	11.0	Aliases & Descriptions, Publications
2	FGF4	fibroblast growth factor 4	11.0	Aliases & Descriptions
3	MUTYH	mutY homolog (E. coli)	11.0	Summaries
4	TXNL1	thioredoxin-like 1	11.0
5	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
6	DPYD	dihydropyrimidine dehydrogenase	11.0
7	TS13	Temperature sensitivity complementation, ts13	11.0	Publications
8	PTPMT1	protein tyrosine phosphatase, mitochondrial 1	11.0	Publications
9	PAGE4	P antigen family, member 4 (prostate associated)	11.0	Publications
10	NEU2	sialidase 2 (cytosolic sialidase)	11.0	Publications
11	AMIGO2	adhesion molecule with Ig-like domain 2	11.0	Expressions
12	MAGEA10	melanoma antigen family A, 10	11.0	Publications
13	HSPA13	heat shock protein 70kDa family, member 13	11.0	Publications
14	ZNRD1	zinc ribbon domain containing 1	11.0	Publications
15	GAGE1	G antigen 1	11.0	Publications
16	PGA5	pepsinogen 5, group I (pepsinogen A)	11.0	Publications
17	DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	11.0	Publications
18	NNMT	nicotinamide N-methyltransferase	11.0	Publications
19	ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	11.0	Publications
20	RRH	retinal pigment epithelium-derived rhodopsin homolog	11.0
21	DUT	deoxyuridine triphosphatase	11.0	Publications
22	CD70	CD70 molecule	11.0	Publications
23	CD99	CD99 molecule	11.0	Publications
24	ETV4	ets variant 4	11.0	Publications
25	PSCA	prostate stem cell antigen	11.0	Publications
26	PGC	progastricsin (pepsinogen C)	11.0	Publications
27	ATP4A	ATPase, H+/K+ exchanging, alpha polypeptide	11.0
28	KLF3	Kruppel-like factor 3 (basic)	11.0	Publications
29	LIG3	ligase III, DNA, ATP-dependent	11.0	Publications
30	KLF6	Kruppel-like factor 6	11.0
31	PLD2	phospholipase D2	11.0	Publications
32	RAD52	RAD52 homolog (S. cerevisiae)	11.0	Publications
33	KISS1	KiSS-1 metastasis-suppressor	11.0	Publications
34	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	11.0	Publications
35	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.0	Publications
36	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0	Publications
37	POLH	polymerase (DNA directed), eta	11.0	Publications
38	PRDX4	peroxiredoxin 4	11.0	Publications
39	LIG4	ligase IV, DNA, ATP-dependent	11.0	Publications
40	PDXK	pyridoxal (pyridoxine, vitamin B6) kinase	11.0	Publications
41	CCKBR	cholecystokinin B receptor	11.0	Expressions, Publications
42	BCL2A1	BCL2-related protein A1	11.0	Publications
43	GSTM3	glutathione S-transferase mu 3 (brain)	11.0	Publications
44	S100A6	S100 calcium binding protein A6	11.0	Publications
45	HMMR	hyaluronan-mediated motility receptor (RHAMM)	11.0	Publications
46	MUC6	mucin 6, oligomeric mucus/gel-forming	11.0	Publications
47	IRF1	interferon regulatory factor 1	11.0
48	POLQ	polymerase (DNA directed), theta	11.0	Publications
49	NR4A1	nuclear receptor subfamily 4, group A, member 1	11.0	Publications
50	MBD2	methyl-CpG binding domain protein 2	11.0	Publications

Pathways related to stomach cancer according to GeneDecks:

(show top 50)    (show all 243)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.8	BRCA2
2	Cell adhesion PLAU signaling10	10.4	HRAS, SERPINE1, BCAR1, PTK2, MET, PLAT
3	Colorectal cancer20	10.3	BRAF, MAP2K1, CASP9, TGFB1
4	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.2	CASP9, BCL2
5	Glioma Invasiveness36	10.1	PTK2, HMMR, FGF7, FGF4, CD44, BMP6
6	Signal transduction_PTEN pathway41	10.1	PCNA, BCAR1, CASP9, PXN
7	Apoptosis and Autophagy3	10.1	FADD, FASLG, CFLAR, BAX, BCL2A1, BCL2
8	Cell adhesion_PLAU signaling41	10.0	HGF, ILK, SERPINE1, BCAR1, MET, PLAU
9	Development_HGF signaling pathway41	9.8	MAP2K1, HRAS, PLAU, HGF, JUN, CDH1
10	Glioblastoma Multiforme36	9.6	HRAS, APC, IGF2, SRC, TP53, CDKN1A
11	Akt Signaling36	9.5	CHUK, FGF4, FGF7, MET, IL10, IL18
12	Melanoma20	9.5	FGF7, MET, MAPK1, MAP2K1, CCND1, IGF1
13	Apoptosis and survival TNFR1 signaling pathway10	9.4	MAPK10, CASP8, TNF, CFLAR, CASP9, CASP3
14	Endometrial cancer20	9.3	ERBB2, MAPK1, CCND1, HRAS, TP53, CTNNB1
15	TNF-Induced Apoptosis Implicating Sphingolipids36	9.3	CASP10, CASP3, CASP8, CASP9, MAP2K1, MAPK1
16	DNA Repair Mechanisms36	9.3	POLH, POLQ, OGG1, LIG3, LIG4, RAD51
17	Germ Cell-Sertoli Cell Junction Dynamics36	9.2	PXN, ILK, CDH2, MAPK14, HRAS, TNF
18	EGF Pathway36	9.2	BRAF, MYC, CHUK, MUC1, PXN, CTNNB1
19	Apoptosis and survival_TNFR1 signaling pathway41	9.1	CHUK, TNF, CASP9, BCL2, BAX, CFLAR
20	Endothelin-1 Signaling Pathway36	9.0	IL18, IL1A, IL1B, MAPK10, MAPK1, CASP3
21	Signal transduction PTEN pathway10	8.9	MAP2K1, IGF1, CASP3, CASP9, HRAS, SRC
22	Apoptosis20	8.9	FAS, FADD, FASLG, IL1B, IL1A, CFLAR
23	Focal adhesion20	8.8	ERBB2, SRC, PXN, BCAR1, BCL2, JUN
24	ILK Signaling36	8.7	BCAR1, PTGS2, PTK2, CTNNB1, PXN, ERBB2
25	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.6	TP53, ERBB2, HRAS, CASP9, BCL2, BAX
26	Cell Cycle / Checkpoint Control3	8.5	RAD52, RAD51, BRCA2, BRCA1, NBN, RB1
27	Bladder cancer20	8.5	MMP2, CDH1, CDKN1A, MYC, VEGFA, BRAF
28	Cellular Apoptosis Pathway36	8.4	BCL2, TP53, MET, FGFR2, FGF7, FGF4
29	ERK Signaling36	8.3	BMP6, MYC, BRAF, CHUK, MAPK1, IL1B
30	14-3-3 Induced Apoptosis36	8.3	LTA, TNF, CASP9, CASP8, CASP3, MAPK14
31	Prostate cancer20	8.1	MAPK1, MAP2K1, CCND1, IGF1, CASP9, HRAS
32	PEDF Induced Signaling36	8.0	MAPK1, MAP2K1, CASP8, HRAS, LTA, HGF
33	Immune response_IL-1 signaling pathway41	7.7	CP, NOS2, PTGS2, TNF, F3, MAPK10
34	STAT3 Pathway36	7.7	BCL2, BAX, CDKN1A, MET, IL10, IL18
35	MAPK signaling pathway20	7.7	MYC, BRAF, TGFB1, FASLG, FAS, MAPK14
36	Immune response IL-1 signaling pathway10	7.6	CHUK, JUN, IRF1, CP, NOS2, PTGS2
37	Molecular Mechanisms of Cancer36	7.6	FGF4, FGFR2, MET, APC, FADD, MAPK1
38	Tuberculosis20	7.5	MAPK14, MAPK10, MAPK1, CASP10, FADD, BAX
39	Chagas disease (American trypanosomiasis)20	7.5	TGFB1, NOS2, SERPINE1, CHUK, CFLAR, JUN
40	Colorectal Cancer Metastasis36	7.4	CASP9, MAP2K1, MAPK1, APC, MLH1, MMP9
41	TGF-Beta Pathway36	7.4	BMP6, IL1A, IL18R1, IL18, IL10, MET
42	Pancreatic Adenocarcinoma36	7.4	HGF, MAPK1, TGFB1, SRC, PTGS2, TP53
43	PAK Pathway36	7.4	IGF1, CASP10, CASP3, CASP8, CASP9, HRAS
44	MIF Regulation of Innate Immune Cells36	7.2	LTA, HGF, PTGS2, TNF, MAPK1, IL1B
45	JAK-STAT Pathway36	7.2	FGFR2, IGF2, IGF1, HRAS, ERBB2, MAP2K1
46	Antioxidant Action of Vitamin-C36	7.0	HGF, SLC2A1, TGFB1, LTA, PLD2, TNF
47	Pathways in cancer20	6.8	FGFR2, MET, FADD, FAS, MAPK10, MAPK1
48	MAPK Family Pathway36	6.7	LTA, TNF, HRAS, IGF1, IGF2, MAP2K1
49	MAPK Signaling36	6.6	BRAF, MYC, BMP6, BCAR1, CHUK, JUN
50	p38 Signaling36	6.6	BMP6, IL8, MAPK14, IGF2, IGF1, CASP3

Compounds related to stomach cancer according to GeneDecks:

(show top 50)    (show all 562)

id	Compound	Score	Top Affiliating Genes
1	cytosine32 18	11.6	BRCA1, RAD51, CDH1, APC, MBD2, DUT
2	nadph32 18	11.5	SGCB, XRCC1, XPC, FPR1, MGMT, GLUD1
3	glucose32	10.5	KISS1, BRAF, CHUK, CFLAR, MKI67, MGMT
4	pge232	10.3	SGCB, MUC5AC, CDH1, FPR1, IRF1, FGF7
5	p00332	10.1	COG2, RB1, SERPINE1, BRCA1, BRCA2, CHGA
6	bleomycin32 9 9	11.9	BRCA1, BRCA2, LIG3, LIG1, XRCC1, XRCC5
7	fluvastatin32 34 9 9	12.7	COG2, SELP, SERPINE1, MMP9, IL1A, CYP1A1
8	mitomycin c32	9.5	PCNA, RB1, NBN, BRCA1, BRCA2, RAD51
9	rantes32	9.1	SELP, BMP6, CHUK, JUN, CD70, CD44
10	agarose32	9.0	BRCA1, MYC, BCL2, MUC1, MUC2, BAX
11	guanine32 9 18 9	11.9	BRCA1, RAD51, CHGA, UGT1A1, MUTYH, MTHFR
12	rottlerin32 42	9.9	JUN, IL8, MAPK14, MAPK1, MAP2K1, CCND1
13	daunorubicin32 9 9	10.9	MYC, BCL2, BAX, FASLG, FAS, CASP3
14	nitric oxide32 9 18 9	11.8	COG2, KLF6, SGCB, RB1, SELP, NAT1
15	acetaminophen32 34 9 18 9	12.8	PCNA, NAT2, MYC, UGT1A1, GPT, CYP1A1
16	c2ceramide32	8.8	CHUK, BAX, JUN, IL1B, MAPK14, CASP3
17	methylmethanesulfonate32	8.7	PCNA, NBN, BRCA1, BRCA2, RAD51, RAD52
18	pentoxifylline32 9 9	10.7	SELP, BMP6, MMP2, FPR1, IL10, IL18
19	flavopiridol32 9 9	10.6	RB1, VEGFA, BCL2, UGT1A1, BAX, CFLAR
20	lipid32	8.6	COG2, RB1, SERPINE1, BRAF, BRCA1, CHGA
21	thapsigargin32 42	9.4	SGCB, PCNA, SERPINE1, BCL2, S100A6, FPR1
22	azathioprine32 34 9 9	11.4	PCNA, MUC2, MTHFR, S100A6, CD44, CDH1
23	superoxide32 18	9.3	SGCB, RB1, CHUK, MTR, S100A6, S100A8
24	phenobarbital32 9 9	10.3	PCNA, MYC, UGT1A1, GSTM1, GPT, IGF2
25	losartan32 34 9 9	11.2	PCNA, SELP, SERPINE1, BMP6, UGT1A1, IGFBP3
26	geldanamycin32 9 9	10.2	BRAF, VEGFA, CFLAR, JUN, CDKN1A, CDH1
27	suberoylanilide hydroxamic acid32	8.2	MYC, BCL2, BAX, CFLAR, CDKN1A, CDH1
28	parthenolide32	8.1	CHUK, MMP9, IL8, FASLG, MAPK14, MAPK10
29	vitamin d32	7.9	SERPINE1, BMP6, CHGA, MTHFR, JUN, CDKN1A
30	docetaxel32 34 9 9	10.8	BRCA1, BRCA2, VEGFA, MYC, BCL2, UMPS
31	arachidonic acid32 9 18 9	10.8	SELP, UGT1A1, S100A8, CDH2, CDH1, FPR1
32	glutamine32	7.8	PCNA, BRCA1, BRCA2, BMP6, MTR, XRCC1
33	adpribose32	7.7	PCNA, RB1, BRCA1, BRCA2, LIG3, LIG1
34	thyroxine32 18	8.6	COG2, PCNA, UGT1A1, CEACAM5, CEACAM7, CEACAM3
35	creatinine32	7.6	PCNA, SELP, BMP6, CHGA, MUC1, MTHFR
36	estrogen32	7.6	COG2, KLF6, KISS1, PCNA, SERPINE1, NAT1
37	aspirin32 34 18	9.4	COG2, PCNA, SELP, SERPINE1, BMP6, CHUK
38	formaldehyde32 18	8.4	PCNA, RB1, SELP, CHGA, MUC1, CD44
39	rosiglitazone32 9 18 9	10.3	COG2, SERPINE1, JUN, CDKN1A, MMP2, MMP9
40	thymidylate32	7.2	PCNA, RB1, BRCA1, VEGFA, RAD51, BCL2
41	wortmannin32 42	8.1	SGCB, BRAF, RAD51, LIG4, BCAR1, BCL2
42	methotrexate32 34 42 9 9	10.5	PCNA, RB1, SERPINE1, NAT2, BRCA1, BRCA2
43	triptolide32	6.2	VEGFA, BCL2, BAX, JUN, IL1B, IL8
44	paraffin32	5.9	PCNA, RB1, BRAF, BRCA1, BRCA2, VEGFA
45	arsenite32 18	6.7	PCNA, VEGFA, MYC, LIG3, BCL2, CHUK
46	thymidine32 18	6.4	PCNA, RB1, BRCA1, BRCA2, MYC, BMP6
47	tamoxifen32 34 9 9	8.3	PCNA, BRCA1, BRCA2, VEGFA, MYC, BMP6
48	butyrate32	4.9	PCNA, RB1, MYC, BMP6, BCL2, MUC1
49	pd 98,05932	4.8	RB1, SERPINE1, BRAF, MYC, BMP6, BCAR1
50	genistein32 9 18 9	6.2	SGCB, PCNA, RB1, SELP, SERPINE1, BRCA1

Cellular components related to stomach cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	death-inducing signaling complex	GO:031264	10.3	CFLAR, FADD, FAS, CASP8
2	nucleoplasm	GO:005654	8.0	POLH, REV1, JUN, XPC, XRCC5, XRCC4
3	cytosol	GO:005829	7.2	CASP9, HRAS, TXN, TP53, DOK1, CASP8
4	extracellular region	GO:005576	6.6	TXN, IGF1, IGFBP3, IGF2, ANXA1, MBL2
5	extracellular space	GO:005615	6.4	AFP, FASLG, IL8, IL1B, IL1A, IL18
6	cytoplasm	GO:005737	6.0	HMMR, ERCC1, TXNL1, TP53, TERT, PTGS2
7	nucleus	GO:005634	5.6	CASP9, ETV4, HRAS, ERCC5, ERBB2, ERCC1

Biological processes related to stomach cancer according to GeneDecks:

(show top 50)    (show all 57)

id	Name	GO ID	Score	Top Affiliating Genes
1	double-strand break repair	GO:006302	10.7	TP53, ERCC1, XRCC5, XRCC4, LIG1, LIG4
2	heterocycle metabolic process	GO:046483	10.6	CYP2E1, CYP2C19, CYP3A4, CYP1A2, UGT1A1
3	response to X-ray	GO:010165	10.5	ERCC6, ERCC1, CCND1, ANXA1, XRCC4, LIG4
4	drug metabolic process	GO:017144	10.4	CYP2C19, CYP2E1, CYP2A6, CYP3A4, CYP1A2, UGT1A1
5	DNA repair	GO:006281	10.3	POLH, POLQ, OGG1, TYMS, ERCC6, ERCC1
6	fibroblast growth factor receptor signaling pathway	GO:008543	10.2	CASP9, HRAS, SRC, NR4A1, KRAS, MAP2K1
7	neuron apoptotic process	GO:051402	10.1	GAPDH, TP53, CASP3, FAS, BAX, BCL2
8	activation of pro-apoptotic gene products	GO:008633	10.1	CASP8, FAS, FADD, FASLG, BAX, BCL2
9	striated muscle cell differentiation	GO:051146	10.1	KRAS, HRAS, MAPK14, CDH2, RB1
10	base-excision repair	GO:006284	10.0	OGG1, TP53, ERCC6, XRCC1, MUTYH, LIG1
11	induction of apoptosis by intracellular signals	GO:008629	9.9	TP53, MYC, BCL2, BAX, CDKN1A, CASP3
12	epidermal growth factor receptor signaling pathway	GO:007173	9.8	NR4A1, KRAS, HBEGF, TGFB1, PXN, SRC
13	nucleotide-excision repair	GO:006289	9.8	OGG1, TP53, ERCC6, ERCC1, ERCC5, XPC
14	xenobiotic metabolic process	GO:006805	9.8	GGT1, NAT1, NAT2, UGT1A1, ADH1C, ADH1B
15	response to gamma radiation	GO:010332	9.8	TP53, ERCC6, IL1B, IL1A, XRCC4, BAX
16	positive regulation of neuron apoptotic process	GO:043525	9.7	NQO1, TNF, CASP9, CASP3, FASLG, IL18
17	organ regeneration	GO:031100	9.7	AFP, HGF, TGFB1, NNMT, CCND1, MKI67
18	positive regulation of epithelial cell proliferation	GO:050679	9.7	BMP6, FGF7, FGFR2, IGF1, HRAS, ERBB2
19	Ras protein signal transduction	GO:007265	9.6	KRAS, SRC, DOK1, TP53, HRAS, IGF1
20	insulin receptor signaling pathway	GO:008286	9.6	KRAS, DOK1, HRAS, IGF2, MAP2K1, MAPK1
21	negative regulation of neuron apoptotic process	GO:043524	9.6	KRAS, HRAS, ILK, JUN, XRCC4, BAX
22	cell cycle arrest	GO:007050	9.5	APC, MAP2K1, HRAS, TP53, TGFB1, ILK
23	positive regulation of fibroblast proliferation	GO:048146	9.5	IGF1, CDKN1A, JUN, S100A6, XRCC4, LIG4
24	response to radiation	GO:009314	9.5	BCL2, JUN, MMP9, IL18, TXN, TGFB1
25	positive regulation of cell division	GO:051781	9.5	TGFB1, IGF2, APC, IL1B, IL1A, FGFR2
26	cell proliferation	GO:008283	9.5	MAP2K1, CCKBR, HRAS, ERBB2, ERCC1, TXN
27	response to DNA damage stimulus	GO:006974	9.3	CCND1, CASP3, CASP9, TP53, APC, CDKN1A
28	response to organic cyclic compound	GO:014070	9.3	CTSB, PTGS2, CCND1, ANXA1, IL1A, MET
29	positive regulation of MAPK cascade	GO:043410	9.2	IGF1, IGFBP3, IGF2, ILK, FGFR2, INS
30	positive regulation of cell migration	GO:030335	9.2	TGFB1, HBEGF, PTK2, F3, MAP2K1, APC
31	small molecule metabolic process	GO:044281	9.1	ABCB1, PDXK, NNMT, PLD2, NQO1, CYP2E1
32	response to lipopolysaccharide	GO:032496	9.1	FAS, F3, CASP8, PTGS2, LTA, FASLG
33	signal transduction	GO:007165	9.1	TXN, ERBB2, HRAS, IGF1, MAP2K1, DOK1
34	induction of apoptosis	GO:006917	9.1	RUNX3, TGFB1, LTA, TNF, CASP3, CASP10
35	positive regulation of mitosis	GO:045840	8.9	INS, MET, IL1A, IL1B, IGF2, IGF1
36	response to glucocorticoid stimulus	GO:051384	8.9	SI, KRAS, PLAT, PTGS2, TNF, MAP2K1
37	response to estradiol stimulus	GO:032355	8.7	TGFB1, CTNNB1, PTGS2, CASP8, F3, ANXA1
38	positive regulation of cell proliferation	GO:008284	8.7	CCKBR, IGF2, IGF1, HRAS, PTK2, KRAS
39	positive regulation of protein kinase B signaling cascade	GO:051897	8.7	TGFB1, HBEGF, PTK2, TNF, F3, IGF1
40	positive regulation of apoptotic process	GO:043065	8.6	CTNNB1, PTGS2, TNF, TP53, IGFBP3, ANXA1
41	anti-apoptosis	GO:006916	8.6	ANXA1, IGF1, AMIGO2, F3, TNF, TERT
42	MAPK cascade	GO:000165	8.5	TGFB1, KRAS, TNF, HRAS, MAP2K1, MAPK1
43	positive regulation of protein phosphorylation	GO:001934	8.3	TGFB1, KRAS, PTK2, TNF, ERBB2, HRAS
44	negative regulation of apoptotic process	GO:043066	8.3	FGF4, APC, CASP3, ERCC5, ERCC1, TP53
45	response to hypoxia	GO:001666	8.2	TNF, PLAT, NOS2, LTA, TGFB1, FAS
46	blood coagulation	GO:007596	8.1	PTK2, SRC, PLAT, PLAU, NOS2, KRAS
47	apoptotic process	GO:006915	8.1	MAPK14, MAPK1, CCKBR, CASP10, CASP3, CASP8
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	IL1B, FADD, MAPK14, IGF1, HRAS, TP53
49	response to drug	GO:042493	7.3	NBN, FAS, APC, IL10, MET, MGMT
50	negative regulation of cell proliferation	GO:008285	7.2	IGF1, HRAS, TP53, TNF, PTGS2, CTNNB1

Molecular functions related to stomach cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	damaged DNA binding	GO:003684	10.6	POLH, POLQ, OGG1, ERCC1, XPC, XRCC1
2	protein C-terminus binding	GO:008022	9.9	ERCC6, ERCC1, ERBB2, HRAS, MAPK14, MKI67
3	protease binding	GO:002020	8.6	TNF, TP53, F3, INS, CD70, BCL2
4	growth factor activity	GO:008083	8.5	IGF1, HBEGF, TYMP, TGFB1, HGF, IGF2
5	protein binding	GO:005515	2.5	FAS, CASP3, CASP8, CASP9, GLUD1, HRAS