MCID: STM004
MIFTS: 69

Stomach Cancer malady

Genetic diseases, Rare diseases, Cancer diseases, Gastrointestinal diseases categories
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Summaries for Stomach Cancer

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MedlinePlus:33 The stomach is an organ between the esophagus and the small intestine. it mixes food with stomach acid and helps digest protein. stomach cancer mostly affects older people - two-thirds of people who have it are over age 65. your risk of getting it is also higher if you have had a helicobacter pylori infection have had stomach inflammation are a man eat lots of salted, smoked, or pickled foods smoke cigarettes have a family history of stomach cancer it is hard to diagnose stomach cancer in its early stages. indigestion and stomach discomfort can be symptoms of early cancer, but other problems can cause the same symptoms. in advanced cases, there may be blood in your stool, vomiting, unexplained weight loss, jaundice, or trouble swallowing. doctors diagnose stomach cancer with a physical exam, blood and imaging tests, an endoscopy, and a biopsy. because it is often found late, it can be hard to treat stomach cancer. treatment options include surgery, chemotherapy, radiation or a combination. nih: national cancer institute

MalaCards based summary: Stomach Cancer, also known as cancer of the stomach, is related to gastric cancer, somatic and prostate cancer. An important gene associated with Stomach Cancer is FGFR2 (fibroblast growth factor receptor 2), and among its related pathways are Angiogenesis and Downstream Signaling Events Of B Cell Receptor (BCR). The drugs cisplatin and floxuridine and the compounds agar and 1-Phosphatidyl-D-myo-inositol have been mentioned in the context of this disorder. Affiliated tissues include the stomach, lung and liver, and related mouse phenotype tumorigenesis.

Disease Ontology:8 A gastrointestinal system cancer that is located in the stomach.

Wikipedia:65 Stomach cancer or gastric cancer, is when cancer develops from the lining of the stomach. Early symptoms... more...

Descriptions from OMIM:46 613659,137215

Aliases & Classifications for Stomach Cancer

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Stomach Cancer, Aliases & Descriptions:

Name: Stomach Cancer 8 42 10 33
Cancer of the Stomach 8 22 62
Gastric Carcinoma 8 44 62
Stomach Carcinoma 8 42 62
Malignant Tumor of Greater Curve of Stomach 8 62
Malignant Tumor of Lesser Curve of Stomach 8 62
Malignant Neoplasm of Body of Stomach 8 62
Malignant Tumor of Body of Stomach 8 62
Carcinoma of Stomach 8 62
Gastric Cancer 44 62
 
Malignant Neoplasm of Lesser Curve of Stomach Unspecified 8
Ca Greater Curvature of Stomach 8
Ca Lesser Curvature - Stomach 8
Malignant Neoplasm of Stomach 62
Adult Stomach Carcinoma 42
Adult Stomach Cancer 42
Ca Body - Stomach 8
Stomach Neoplasms 62
Gastric Neoplasm 8


Classifications:



Related Diseases for Stomach Cancer

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Diseases in the Stomach Cancer family:

Stomach Carcinoma in Situ Stomach Cancer, Familial

Diseases related to Stomach Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1gastric cancer, somatic30.3PIK3CA, MUTYH, FGFR2
2prostate cancer29.3PIK3CA, PSCA, FGFR2, FGF4
3epstein-barr virus-associated gastric carcinoma10.9
4gastric cancer10.5
5esophagitis10.4
6gastritis10.4
7disseminated intravascular coagulation10.4
8atrophic gastritis10.4
9microinvasive gastric cancer10.4
10lymphoepithelioma-like carcinoma10.3
11retinoblastoma10.3
12hypoxia10.3
13situs inversus10.3
14li-fraumeni syndrome10.3
15ataxia telangiectasia10.3
16thyroiditis10.3
17ataxia10.3
18leukemia10.3
19lung cancer10.3
20stomach cancer, familial10.3
21lynch syndrome10.3
22gastric lymphoma10.3
23pyloric stenosis10.3
24gastric small cell carcinoma10.2
25gastric adenosquamous carcinoma10.2
26gastric squamous cell carcinoma10.2
27pancreatic cancer10.2
28xeroderma pigmentosum10.2
29plummer vinson syndrome10.2
30gastric fundus carcinoma10.2
31pernicious anemia10.2
32adenocarcinoma10.2
33peritonitis10.2
34stomach cancer, childhood10.2
35gastric outlet obstruction10.2
36endotheliitis10.2
37glomerulonephritis10.2
38cicatricial pemphigoid10.2
39dumping syndrome10.1
40tubular adenocarcinoma10.1
41intestinal obstruction10.1
42esophageal squamous cell carcinoma10.1
43colorectal cancer10.1
44bloom syndrome10.1
45neuroectodermal tumor10.1
46duodenal ulcer10.1
47asbestosis10.1
48duodenitis10.1
49breast cancer10.1
50cerebrovascular disease10.1

Graphical network of the top 20 diseases related to Stomach Cancer:



Diseases related to stomach cancer

Symptoms for Stomach Cancer

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Clinical features from OMIM:

613659,137215

Drugs & Therapeutics for Stomach Cancer

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Drug clinical trials:

Search ClinicalTrials for Stomach Cancer

Search NIH Clinical Center for Stomach Cancer

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Stomach Cancer

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Genetic tests related to Stomach Cancer:

id Genetic test Affiliating Genes
1 Neoplasm of Stomach22

Anatomical Context for Stomach Cancer

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MalaCards organs/tissues related to Stomach Cancer:

32
Lung, Liver, Bone, Lymph node, Testes, Small intestine, Skin, Breast, Colon, Bone marrow, Endothelial, Kidney, Prostate, Neutrophil, Brain, Heart

FMA organs/tissues related to Stomach Cancer:

14
The stomach

Animal Models for Stomach Cancer or affiliated genes

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MGI Mouse Phenotypes related to Stomach Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9FGFR2, PSCA, DOK1, MUTYH, PTPRH, PIK3CA

Publications for Stomach Cancer

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Articles related to Stomach Cancer:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Pulmonary Tumor Embolism Derived From Stomach Cancer Observation With Serial 18F-FDG PET/CT. (25247270)
2014
2
CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India. (25374213)
2014
3
Microanalysis of stomach cancer glycosaminoglycans. (23604988)
2013
4
Can salt hypothesis explain the trends of mortality from stroke and stomach cancer in Western europe? (22783462)
2012
5
Occupational exposures and risk of stomach cancer by histological type. (22068174)
2012
6
Association between insulin-like growth factor-1 polymorphisms and stomach cancer risk in a Japanese population. (21854509)
2011
7
Association of CASP3 and CASP9 polymorphisms with genetic susceptibility to stomach cancer]. (21644232)
2011
8
Stomach cancer. (21439098)
2011
9
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males. (21133627)
2010
10
Dietary fiber and stomach cancer risk: a case-control study from Italy. (19247788)
2009
11
Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells. (19514731)
2009
12
Preliminary experience using high intensity focused ultrasound for treating liver metastasis from colon and stomach cancer. (19212862)
2009
13
Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells. (19020714)
2008
14
Laparoscopic ultrasonography-assisted retroperitoneal lymph node sampling in patients evaluated for stomach cancer recurrence. (18645082)
2008
15
Detection of expressed IL-32 in human stomach cancer using ELISA and immunostaining. (18852519)
2008
16
Overexpression of phospholipase D suppresses taxotere-induced cell death in stomach cancer cells. (18190795)
2008
17
Pancreaticoduodenectomy for locally advanced stomach cancer: preliminary results. (18844905)
2008
18
Lifestyle-related risk factors for stomach cancer in northeast Thailand. (18439078)
2008
19
A randomized phase II selection trial in patients with advanced/recurrent gastric cancer: Trial for Advanced Stomach Cancer (TASC). (17584825)
2007
20
Dietary habits and stomach cancer in Mizoram, India. (16799882)
2006
21
Contrast-enhanced CT for differentiation of ovarian metastasis from gastrointestinal tract cancer: stomach cancer versus colon cancer. (16928939)
2006
22
Mortality and incidence rates of stomach cancer in the JACC Study. (16127239)
2005
23
Occupation and risk of stomach cancer in Poland. (15837853)
2005
24
Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. (15770773)
2005
25
A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer]. (15231125)
2004
26
Operate on my stomach cancer? Oh, no--not you, or not yet! (15118003)
2004
27
Comparative study between DNA copy number aberrations determined by quantitative microsatellite analysis and clinical outcome in patients with stomach cancer. (15131037)
2004
28
A nested case-control study of stomach cancer in relation to green tea consumption in Japan. (14710220)
2004
29
Undisturbed water gastric emptying in patients of stomach cancer. (15239283)
2004
30
Breast cancer, birth cohorts, and Epstein-Barr virus: methodological issues in exploring the "hygiene hypothesis" in relation to breast cancer, Hodgkin's disease, and stomach cancer. (12750234)
2003
31
BRAF and KRAS mutations in stomach cancer. (14534542)
2003
32
Expression of COX-2 in stomach cancers and its relation to their biological features. (12686777)
2003
33
Promising results in stomach cancer trial. (12217783)
2002
34
A novel telomere elongation in an adriamycin-resistant stomach cancer cell line with decreased telomerase activity. (12018844)
2002
35
Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China: comparison with those in a high-epidemic area. (11714439)
2001
36
Significance of a positive oesophageal margin in stomach cancer. (11021482)
2000
37
Immunogenetic characteristics of patients with stomach cancer and predominant activity of either sympathetic or parasympathetic autonomic nervous system. (11013848)
2000
38
Risk of stomach cancer in patients with peptic ulcer disease. (10658066)
2000
39
Plant sterols and risk of stomach cancer: a case-control study in Uruguay. (11142085)
2000
40
Helicobacter pylori and stomach cancer: a case-control study in Venezuela. (11008915)
2000
41
Endobronchial metastasis from stomach cancer. (10339736)
1999
42
Survival in stomach cancer is improving: results of a nationwide population-based Swedish study. (10450729)
1999
43
Family history and risk of stomach cancer in Warsaw, Poland. (10443951)
1999
44
The risk of stomach cancer in patients with gastric or duodenal ulcer disease. (8657240)
1996
45
Identification of novel genes from stomach cancer cell lines by differential display. (7750094)
1995
46
Pathological prognostic factors in the second British Stomach Cancer Group trial of adjuvant therapy in resectable gastric cancer. (7734309)
1995
47
Factors influencing growth rate of recurrent stomach cancers as determined by analysis of serum carcinoembryonic antigen. (7889481)
1995
48
Stomach cancer risk among black and white men and women: the role of occupation and cigarette smoking. (8542342)
1995
49
A case-series study of p53 nuclear overexpression in early-stage stomach cancer. (8526364)
1995
50
Hormonal therapy for stomach cancer. (1461175)
1992

Variations for Stomach Cancer

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Clinvar genetic disease variations for Stomach Cancer:

6
id Gene Name Type Significance SNP ID Assembly Location
1FGFR2NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro)single nucleotide variantPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
2PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
3PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091

Expression for genes affiliated with Stomach Cancer

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Expression patterns in normal tissues for genes affiliated with Stomach Cancer

Search GEO for disease gene expression data for Stomach Cancer.

Pathways for genes affiliated with Stomach Cancer

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Pathways related to Stomach Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Angiogenesis37
10.1FGFR2, PIK3CA
2
Show member pathways
9.8PIK3CA, FGFR2, FGF4
3
Show member pathways
9.8PIK3CA, FGFR2, FGF4
4
Show member pathways
9.8FGF4, FGFR2, PIK3CA
5
Show member pathways
Signaling Pathways in Glioblastoma37
9.8FGF4, FGFR2, PIK3CA
69.8DOK1, PIK3CA
79.8DOK1, PIK3CA
8
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.5PIK3CA, DOK1, BCL2A1
9
Show member pathways
9.3FGF4, FGFR2, DOK1, PIK3CA

Compounds for genes affiliated with Stomach Cancer

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Sources:
44Novoseek, 24HMDB
See all sources

Compounds related to Stomach Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agar449.8FGF4, FGFR2, PIK3CA
21-Phosphatidyl-D-myo-inositol249.8PIK3CA, PTPMT1
3estrogen449.3FGF4, FGFR2, BCL2A1, APOC1, PIK3CA
4tyrosine448.3PIK3CA, PTPRH, PTPMT1, DOK1, FGFR2, FGF4

GO Terms for genes affiliated with Stomach Cancer

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Biological processes related to Stomach Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of multicellular organism growthGO:04001410.0FGFR2, PIK3CA
2phosphatidylinositol-mediated signalingGO:0480159.9FGF4, FGFR2, PIK3CA
3fibroblast growth factor receptor signaling pathwayGO:0085439.8PIK3CA, FGFR2, FGF4
4epidermal growth factor receptor signaling pathwayGO:0071739.8FGF4, FGFR2, PIK3CA
5negative regulation of mitosisGO:0458399.8AURKAIP1, FGFR2
6Fc-epsilon receptor signaling pathwayGO:0380959.5FGF4, FGFR2, PIK3CA
7insulin receptor signaling pathwayGO:0082869.4FGF4, FGFR2, DOK1, PIK3CA

Molecular functions related to Stomach Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aspartic-type endopeptidase activityGO:0041909.8PGC, PGA5

Products for genes affiliated with Stomach Cancer

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  • Lysates

Sources for Stomach Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet