MCID: STM004
MIFTS: 63

Stomach Cancer malady

Genetic diseases, Rare diseases, Cancer diseases, Gastrointestinal diseases categories

Summaries for Stomach Cancer

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 The stomach is an organ between the esophagus and the small intestine. it mixes food with stomach acid and helps digest protein. stomach cancer mostly affects older people - two-thirds of people who have it are over age 65. your risk of getting it is also higher if you have had a helicobacter pylori infection have had stomach inflammation are a man eat lots of salted, smoked, or pickled foods smoke cigarettes have a family history of stomach cancer it is hard to diagnose stomach cancer in its early stages. indigestion and stomach discomfort can be symptoms of early cancer, but other problems can cause the same symptoms. in advanced cases, there may be blood in your stool, vomiting, unexplained weight loss, jaundice, or trouble swallowing. doctors diagnose stomach cancer with a physical exam, blood and imaging tests, an endoscopy, and a biopsy. because it is often found late, it can be hard to treat stomach cancer. treatment options include surgery, chemotherapy, radiation or a combination. nih: national cancer institute

MalaCards: Stomach Cancer, also known as stomach carcinoma, is related to esophagitis and gastritis. An important gene associated with Stomach Cancer is MUTYH (mutY homolog). The drugs cisplatin and cisplatin pwdr have been mentioned in the context of this disorder. Affiliated tissues include the stomach, lung and liver.

Disease Ontology:9 A gastrointestinal system cancer that is located in the stomach.

Wikipedia:66 Stomach cancer or gastric cancer, is when cancer develops from the lining of the stomach. Early symptoms... more...

Description from OMIM:48 613659,137215

Aliases & Classifications for Stomach Cancer

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 23GTR, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 48OMIM, 41NCIt, 36MeSH, 26ICD10
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Classifications:



Aliases & Descriptions:

stomach cancer 9 44 11 35
stomach carcinoma 9 44 63
malignant tumor of greater curve of stomach 9 63
malignant tumor of lesser curve of stomach 9 63
malignant neoplasm of body of stomach 9 63
cancer of the stomach 9 23
gastric carcinoma 9 46
malignant neoplasm of greater curvature of stomach, unspecified 9
malignant neoplasm of lesser curvature of stomach, unspecified 9
malignant neoplasm of greater curve of stomach unspecified 9
malignant neoplasm of lesser curve of stomach unspecified 9
malignant neoplasm of greater curvature of stomach, nos 9
malignant neoplasm of lesser curvature of stomach, nos 9
malignant tumor of body of stomach 9
ca greater curvature of stomach 9
ca greater curvature - stomach 9
ca lesser curvature of stomach 9
malignant neoplasm of stomach 63
ca lesser curvature - stomach 9
adult stomach carcinoma 44
carcinoma of stomach 9
adult stomach cancer 44
neoplasm of stomach 9
ca body - stomach 9
stomach neoplasms 63
stomach neoplasm 9
gastric neoplasm 9
gastric cancer 46


Related Diseases for Stomach Cancer

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Stomach Cancer:



Diseases related to stomach cancer

Symptoms for Stomach Cancer

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Sources:
48OMIM
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Clinical features from OMIM:

613659,137215

Drugs & Therapeutics for Stomach Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Stomach Cancer

Drug clinical trials:

Search ClinicalTrials for Stomach Cancer

Search NIH Clinical Center for Stomach Cancer

Search CenterWatch for Stomach Cancer

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Stomach Cancer

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Sources:
23GTR
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Genetic tests related to Stomach Cancer:

id Genetic test Affiliating Genes
1 Neoplasm of Stomach23

Anatomical Context for Stomach Cancer

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Stomach Cancer:

34
Lung, Liver, Bone, Lymph node, Testes, Small intestine, Skin, Breast, Colon, Bone marrow, Prostate, Endothelial, Kidney, Heart, Brain

FMA organs/tissues related to Stomach Cancer:

15
The stomach

Animal Models for Stomach Cancer or affiliated genes

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Publications for Stomach Cancer

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Sources:
53PubMed
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Articles related to Stomach Cancer:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Microanalysis of stomach cancer glycosaminoglycans. (23604988)
2013
2
Identification of transporters associated with Etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics. (23197647)
2013
3
Can salt hypothesis explain the trends of mortality from stroke and stomach cancer in Western europe? (22783462)
2012
4
Occupational exposures and risk of stomach cancer by histological type. (22068174)
2012
5
Association between insulin-like growth factor-1 polymorphisms and stomach cancer risk in a Japanese population. (21854509)
2011
6
Association of CASP3 and CASP9 polymorphisms with genetic susceptibility to stomach cancer]. (21644232)
2011
7
Stomach cancer. (21439098)
2011
8
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males. (21133627)
2010
9
Dietary fiber and stomach cancer risk: a case-control study from Italy. (19247788)
2009
10
Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells. (19514731)
2009
11
Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells. (19020714)
2008
12
Laparoscopic ultrasonography-assisted retroperitoneal lymph node sampling in patients evaluated for stomach cancer recurrence. (18645082)
2008
13
Detection of expressed IL-32 in human stomach cancer using ELISA and immunostaining. (18852519)
2008
14
Overexpression of phospholipase D suppresses taxotere-induced cell death in stomach cancer cells. (18190795)
2008
15
Pancreaticoduodenectomy for locally advanced stomach cancer: preliminary results. (18844905)
2008
16
Lifestyle-related risk factors for stomach cancer in northeast Thailand. (18439078)
2008
17
A randomized phase II selection trial in patients with advanced/recurrent gastric cancer: Trial for Advanced Stomach Cancer (TASC). (17584825)
2007
18
Dietary habits and stomach cancer in Mizoram, India. (16799882)
2006
19
Contrast-enhanced CT for differentiation of ovarian metastasis from gastrointestinal tract cancer: stomach cancer versus colon cancer. (16928939)
2006
20
Mortality and incidence rates of stomach cancer in the JACC Study. (16127239)
2005
21
Occupation and risk of stomach cancer in Poland. (15837853)
2005
22
Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. (15770773)
2005
23
A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer]. (15231125)
2004
24
Operate on my stomach cancer? Oh, no--not you, or not yet! (15118003)
2004
25
Comparative study between DNA copy number aberrations determined by quantitative microsatellite analysis and clinical outcome in patients with stomach cancer. (15131037)
2004
26
A nested case-control study of stomach cancer in relation to green tea consumption in Japan. (14710220)
2004
27
Undisturbed water gastric emptying in patients of stomach cancer. (15239283)
2004
28
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population. (15222046)
2004
29
Breast cancer, birth cohorts, and Epstein-Barr virus: methodological issues in exploring the "hygiene hypothesis" in relation to breast cancer, Hodgkin's disease, and stomach cancer. (12750234)
2003
30
BRAF and KRAS mutations in stomach cancer. (14534542)
2003
31
Expression of COX-2 in stomach cancers and its relation to their biological features. (12686777)
2003
32
Promising results in stomach cancer trial. (12217783)
2002
33
A novel telomere elongation in an adriamycin-resistant stomach cancer cell line with decreased telomerase activity. (12018844)
2002
34
Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China: comparison with those in a high-epidemic area. (11714439)
2001
35
Significance of a positive oesophageal margin in stomach cancer. (11021482)
2000
36
Immunogenetic characteristics of patients with stomach cancer and predominant activity of either sympathetic or parasympathetic autonomic nervous system. (11013848)
2000
37
Risk of stomach cancer in patients with peptic ulcer disease. (10658066)
2000
38
Plant sterols and risk of stomach cancer: a case-control study in Uruguay. (11142085)
2000
39
Helicobacter pylori and stomach cancer: a case-control study in Venezuela. (11008915)
2000
40
Endobronchial metastasis from stomach cancer. (10339736)
1999
41
Survival in stomach cancer is improving: results of a nationwide population-based Swedish study. (10450729)
1999
42
Family history and risk of stomach cancer in Warsaw, Poland. (10443951)
1999
43
A topographic analysis of atrophic gastritis and stomach cancer risk. A clinicoepidemiological study in Poland. (9386896)
1997
44
The risk of stomach cancer in patients with gastric or duodenal ulcer disease. (8657240)
1996
45
Identification of novel genes from stomach cancer cell lines by differential display. (7750094)
1995
46
Pathological prognostic factors in the second British Stomach Cancer Group trial of adjuvant therapy in resectable gastric cancer. (7734309)
1995
47
Factors influencing growth rate of recurrent stomach cancers as determined by analysis of serum carcinoembryonic antigen. (7889481)
1995
48
Stomach cancer risk among black and white men and women: the role of occupation and cigarette smoking. (8542342)
1995
49
A case-series study of p53 nuclear overexpression in early-stage stomach cancer. (8526364)
1995
50
Hormonal therapy for stomach cancer. (1461175)
1992

Variations for Stomach Cancer

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Stomach Cancer:

1
id Gene Name Type Significance SNP ID Assembly Location
1FGFR2NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro)single nucleotide variantPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
2PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
3PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091

Expression for genes affiliated with Stomach Cancer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stomach Cancer

Search GEO for disease gene expression data for Stomach Cancer.

Pathways for genes affiliated with Stomach Cancer

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Compounds for genes affiliated with Stomach Cancer

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GO Terms for genes affiliated with Stomach Cancer

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17Gene Ontology
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Biological processes related to Stomach Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.7PGC, PGA5

Molecular functions related to Stomach Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aspartic-type endopeptidase activityGO:0041909.7PGC, PGA5

Products for genes affiliated with Stomach Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Stomach Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet