MCID: STM004
MIFTS: 62

Stomach Cancer malady

Cancer, Gastrointestinal categories

Summaries for Stomach Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 The stomach is an organ between the esophagus and the small intestine. it mixes food with stomach acid and helps digest protein. stomach cancer mostly affects older people - two-thirds of people who have it are over age 65. your risk of getting it is also higher if you have had a helicobacter pylori infection have had stomach inflammation are a man eat lots of salted, smoked, or pickled foods smoke cigarettes have a family history of stomach cancer it is hard to diagnose stomach cancer in its early stages. indigestion and stomach discomfort can be symptoms of early cancer, but other problems can cause the same symptoms. in advanced cases, there may be blood in your stool, vomiting, unexplained weight loss, jaundice, or trouble swallowing. doctors diagnose stomach cancer with a physical exam, blood and imaging tests, an endoscopy, and a biopsy. because it is often found late, it can be hard to treat stomach cancer. treatment options include surgery, chemotherapy, radiation or a combination. nih: national cancer institute

MalaCards: Stomach Cancer, also known as stomach carcinoma, is related to adenocarcinoma and peritoneal carcinoma. An important gene associated with Stomach Cancer is MUTYH (mutY homolog). The drugs cisplatin and floxuridine have been mentioned in the context of this disorder. Affiliated tissues include the stomach, liver and brain.

Disease Ontology:8 A gastrointestinal system cancer that is located in the stomach.

Wikipedia:64 Stomach cancer, or gastric cancer, refers to cancer arising from any part of the stomach. Stomach cancer... more...

Description from OMIM:47 613659,137215

Aliases & Classifications for Stomach Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 34MedlinePlus, 61UMLS, 22GTR, 45Novoseek, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Aliases & Descriptions:

stomach cancer 8 43 10 34
stomach carcinoma 8 43 61
malignant tumor of greater curve of stomach 8 61
malignant tumor of lesser curve of stomach 8 61
malignant neoplasm of body of stomach 8 61
neoplasm of stomach 8 22
gastric carcinoma 8 45
malignant neoplasm of greater curvature of stomach, unspecified 8
malignant neoplasm of lesser curvature of stomach, unspecified 8
malignant neoplasm of greater curve of stomach unspecified 8
malignant neoplasm of lesser curve of stomach unspecified 8
malignant neoplasm of greater curvature of stomach, nos 8
malignant neoplasm of lesser curvature of stomach, nos 8
malignant tumor of body of stomach 8
ca greater curvature of stomach 8
ca greater curvature - stomach 8
ca lesser curvature of stomach 8
ca lesser curvature - stomach 8
malignant neoplasm of stomach 61
adult stomach carcinoma 43
cancer of the stomach 8
adult stomach cancer 43
carcinoma of stomach 8
stomach neoplasms 61
ca body - stomach 8
gastric neoplasm 8
stomach neoplasm 8
gastric cancer 45


Related Diseases for Stomach Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Stomach Cancer family:

stomach cancer, familial

Diseases related to Stomach Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.3CEACAM7, PSCA, CCKBR
2peritoneal carcinoma10.6
3stomach disease10.5
4h. pylori infection10.5
5atrophic gastritis10.4
6colorectal cancer10.4
7gastric linitis plastica10.3
8cronkhite-canada syndrome10.3
9microinvasive gastric cancer10.3
10situs inversus10.3
11neuroendocrine carcinoma10.3
12hypoxia10.3
13ataxia telangiectasia10.3
14signet ring cell adenocarcinoma10.3
15gastric signet ring cell adenocarcinoma10.3
16spleen cancer10.3
17ataxia10.3
18cancer progression/metastasis10.3
19stomach cancer, childhood10.3
20xeroderma pigmentosum10.2
21thyroid cancer10.2
22plummer vinson syndrome10.2
23xeroderma pigmentosum, group c10.2
24xeroderma pigmentosum, group g10.2
25bone carcinoma10.2
26gastric ulcer10.2
27pernicious anemia10.2
28stomach cancer, familial10.2
29bone marrow cancer10.2
30gastric outlet obstruction10.2
31stomach carcinoma in situ10.2
32gastric tubular adenocarcinoma10.2
33dumping syndrome10.2
34tubular adenocarcinoma10.2
35squamous cell carcinoma10.2
36retroperitoneal fibrosis10.2
37esophageal squamous cell carcinoma10.2
38breast cancer, lobular10.2
39small cell carcinoma10.2
40cicatricial pemphigoid10.2
41diffuse gastric cancer10.2
42epstein-barr virus-associated gastric carcinoma10.2
43bloom syndrome10.1
44duodenal ulcer10.1
45asbestosis10.1
46adenoma10.1
47vascular cancer10.1
48oral cancer10.1
49gastric lymphoma10.1
50pellagra10.1

Graphical network of the top 20 diseases related to Stomach Cancer:



Diseases related to stomach cancer

Clinical Features for Stomach Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

613659,137215

Drugs & Therapeutics for Stomach Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Stomach Cancer

Drug clinical trials:

Search ClinicalTrials for Stomach Cancer

Search NIH Clinical Center for Stomach Cancer

Search CenterWatch for Stomach Cancer

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Stomach Cancer

Sources:
22GTR
See all sources

Genetic tests related to Stomach Cancer:

id Genetic test Affiliating Genes
1 Neoplasm Of Stomach22

Anatomical Context for Stomach Cancer

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Stomach Cancer:

33
Liver, Brain, Kidney, Lymph node, Lung, Bone marrow, Heart, Small intestine, Colon, Pancreas, Thyroid, Breast, Prostate, Cervix, T cells, B cells, Endothelial

FMA organs/tissues related to Stomach Cancer:

14
The stomach

Animal Models for Stomach Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Stomach Cancer

Sources:
51PubMed
See all sources

Articles related to Stomach Cancer:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Occupational exposures and risk of stomach cancer by histological type. (22068174)
2012
2
Trends in stomach cancer mortality rates in Japan, USA, UK, France and Korea based on the WHO mortality database. (22291209)
2012
3
Strategic aspects of stomach cancer surgery. (21525533)
2011
4
Glycomic and glycoproteomic analysis of serum from patients with stomach cancer reveals potential markers arising from host defense response mechanisms. (21142185)
2011
5
Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells. (19857042)
2010
6
A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. (19924550)
2010
7
Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer. (19561529)
2010
8
Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells. (19514731)
2009
9
Comparison of time trends in stomach cancer incidence (1973-2002) in Asia, from Cancer Incidence in Five Continents, Vols IV-IX. (19103673)
2009
10
Stomach cancer presenting with rectal stenosis: Schnitzler's metastasis. (19482277)
2009
11
Analysis of the relationship between socioeconomic factors and stomach cancer incidence in Slovenia. (16575465)
2006
12
International comparisons of cumulative risk of stomach cancer, from Cancer Incidence in Five Continents Vol. VIII. (16517837)
2006
13
Helicobacter pylori and histopathological changes of gastric mucosa in Uganda population with varying prevalence of stomach cancer. (16245994)
2005
14
Comparison of Cancer Mortality (Stomach Cancer) in Five Countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). (15709097)
2005
15
A nested case-control study of stomach cancer in relation to green tea consumption in Japan. (14710220)
2004
16
Glut1 expression and its relation with the absorption of 18F-FDG in stomach cancer]. (15312513)
2004
17
Synthetic CDCA derivatives-induced apoptosis of stomach cancer cell line SNU-1 cells. (20396553)
2004
18
The expression of GAGE gene can predict aggressive biologic behavior of intestinal type of stomach cancer. (15362791)
2004
19
Breast cancer, birth cohorts, and Epstein-Barr virus: methodological issues in exploring the "hygiene hypothesis" in relation to breast cancer, Hodgkin's disease, and stomach cancer. (12750234)
2003
20
Aggregation of stomach cancer history in parents and offspring in comparison with other sites. (12913033)
2003
21
Polyozellus multiplex, a Korean wild mushroom, as a potent chemopreventive agent against stomach cancer. (14561527)
2003
22
A novel telomere elongation in an adriamycin-resistant stomach cancer cell line with decreased telomerase activity. (12018844)
2002
23
Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China. (12406553)
2002
24
CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications. (12239615)
2002
25
Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis. (11710638)
2001
26
Oolong tea polyphenol extract induces apoptosis in human stomach cancer cells. (11205279)
2000
27
Molecular aspects of invasion and metastasis of stomach cancer. (11217448)
2000
28
Exercise therapy effect on natural killer cell cytotoxic activity in stomach cancer patients after curative surgery. (10857523)
2000
29
Sequential numerical changes of chromosomes 7 and 18 in diffuse-type stomach cancer cell lines: combined comparative genomic hybridization, fluorescence in situ hybridization, and ploidy analyses. (10748289)
2000
30
Endobronchial metastasis from stomach cancer. (10339736)
1999
31
Economic status and occupational correlates of stomach cancer in the rubber industry. (10703182)
1999
32
Associations between stomach cancer incidence and drinking water contamination with atrazine and nitrate in Ontario (Canada) agroecosystems, 1987-1991. (10597979)
1999
33
An influence of preop chemotherapy on the hormonal status of the patient with stomach cancer]. (9787563)
1998
34
Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers. (9873831)
1998
35
Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer. (9681807)
1998
36
Diet and stomach cancer in Korea. (9209012)
1997
37
Stomach cancer incidence in Brazil: an ecologic study with selected risk factors. (10886927)
1997
38
Racial factors cannot explain superior Japanese outcomes in stomach cancer. (9006560)
1997
39
Treatments for second malignancies after gastrectomy for stomach cancer. (8682461)
1996
40
Development of a nursing diagnosis system using a back-propagation neural network model: an application for stomach cancer patients. (8591459)
1995
41
Accuracy of self-report for stomach cancer screening. (7730914)
1994
42
Proteolytic enzyme activity in stomach cancer patients with various prognoses]. (8079438)
1994
43
Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. (7688222)
1993
44
Frequent amplification of the c-met gene in scirrhous type stomach cancer. (1333188)
1992
45
A comparative case-control analysis of stomach cancer and atrophic gastritis. (2208116)
1990
46
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. (2377625)
1990
47
Excess mortality from stomach cancer, lung cancer, and asbestosis and/or mesothelioma in crocidolite mining districts in South Africa. (3940441)
1986
48
Trends in lung, stomach, breast and colorectal cancer in the Republic of Ireland. (6526636)
1984
49
An unusual case of complete duodenal obstruction with massive stomach dilatation caused by recurrent cervical cancer. (7203160)
1981
50
The relationship between pernicious anemia and cancer of the stomach. (5443799)
1970

Genetic Variations for Stomach Cancer

Expression for genes affiliated with Stomach Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Stomach Cancer

Search GEO for disease gene expression data for Stomach Cancer.

Pathways for genes affiliated with Stomach Cancer

Compounds for genes affiliated with Stomach Cancer

GO Terms for genes affiliated with Stomach Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Stomach Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.7PGA5, PGC, CCKBR

Molecular functions related to Stomach Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aspartic-type endopeptidase activityGO:00419010.6PGA5, PGC

Products for genes affiliated with Stomach Cancer

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Sources for Stomach Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet