Aliases & Classifications for Stomach Disease

MalaCards integrated aliases for Stomach Disease:

Name: Stomach Disease 12 14
Stomach Diseases 42 69
Gastropathy 12 52
Stomach Disorders 41
Stomach Disorder 12
Gastric Disorder 52
Gastric Disease 12


External Ids:

Disease Ontology 12 DOID:76
MeSH 42 D013272
NCIt 47 C26886
UMLS 69 C0038354

Summaries for Stomach Disease

MedlinePlus : 41 your stomach is an organ between your esophagus and small intestine. it is where digestion of protein begins. the stomach has three tasks. it stores swallowed food. it mixes the food with stomach acids. then it sends the mixture on to the small intestine. most people have a problem with their stomach at one time or another. indigestion and heartburn are common problems. you can relieve some stomach problems with over-the-counter medicines and lifestyle changes, such as avoiding fatty foods or eating more slowly. other problems like peptic ulcers or gerd require medical attention. you should see a doctor if you have any of the following: blood when you have a bowel movement severe abdominal pain heartburn not relieved by antacids unintended weight loss ongoing vomiting or diarrhea nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Stomach Disease, also known as stomach diseases, is related to non-hypoproteinemic hypertrophic gastropathy and functional gastric disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Stomach Disease is DDX21 (DExD-Box Helicase 21), and among its related pathways/superpathways are Peptide ligand-binding receptors and Salivary secretion. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and lung, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system disease that is located in the stomach.

Wikipedia : 72 Stomach diseases (or gastropathy) include gastritis, gastroparesis, diarrhea, Crohn\'s disease and... more...

Related Diseases for Stomach Disease

Diseases related to Stomach Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 non-hypoproteinemic hypertrophic gastropathy 11.9
2 functional gastric disease 11.7
3 rhabdomyosarcoma 10.8 ATP4A HRH2
4 scrotum melanoma 10.8 ATP12A ATP4A
5 neonatal marfan syndrome 10.8 CXCL8 PTGS2
6 congenital aphakia 10.8 ATP12A ATP4A
7 urethral calculus 10.7 ATP12A ATP4A
8 breast ductal adenoma 10.7 ATP12A ATP4A
9 hypopituitarism 10.7 ATP12A ATP4A
10 abnormal pupillary function 10.7 ATP12A ATP4A
11 conjunctival concretion 10.7 CXCL8 HRH2 PTGS2
12 enamel erosion 10.7 ATP4A SST
13 lacrimal apparatus disease 10.7 ATP4A CXCL8 HRH2
14 cushing's syndrome 10.6 ATP4A CCK PTGS2
15 atheroembolism of kidney 10.6 ATP12A ATP4A
16 shwartzman phenomenon 10.6 ATP12A ATP4A PTGS2
17 ragweed sensitivity 10.6 CXCL8 PTGS1 PTGS2
18 adult xanthogranuloma 10.6 ATP12A ATP4A HRH2
19 neovascular glaucoma 10.6 CXCL8 PTGS2 TRPV1
20 villous adenocarcinoma 10.6 ATP12A ATP4A PTGS2
21 bladder neck cancer 10.6 ATP12A ATP4A HRH2
22 eyelid neoplasm 10.6 CXCL8 TLR9 TRPV1
23 microphthalmia, syndromic 12 10.6 ATP12A ATP4A
24 dehydration polycythemia 10.6 CXCL8 TLR9 TRPV1
25 pelvic varices 10.6 CXCL8 TLR9 TRPV1
26 methotrexate-associated lymphoproliferation 10.6 SST TLR9
27 synostosis 10.6 ATP12A ATP4A
28 brain ependymoma 10.6 ATP4A HRH2 PTGS1 PTGS2
29 amyotrophic lateral sclerosis type 5 10.6 ATP12A ATP4A GIF
30 pervasive developmental disorder 10.6 CCK GHRL TRPV1
31 pandas 10.6 GAST SST
32 ovarian remnant syndrome 10.6 PTGS1 PTGS2
33 primary progressive multiple sclerosis 10.5 GAST HRH2 SST
34 gastritis 10.5
35 chondroma 10.5 CCK SST TRPV1
36 hypertrichosis 10.5 SST TLR9 TRPV1
37 substance-induced psychosis 10.5 ATP4A GAST
38 color blindness 10.5 GAST GIF SST
39 villous adenoma 10.5 CXCL8 PTGS2 TLR9
40 cervicitis 10.5 CCK PTGS1 PTGS2 TRPV1
41 mesenchymal cell neoplasm 10.5 CXCL8 PTGS2 TLR9 TRPV1
42 polysyndactyly with cardiac malformation 10.5 ATP12A ATP4A
43 survival motor neuron spinal muscular atrophy 10.4 GHRL SST TLR9 TRPV1
44 lymphoma, malt, somatic 10.4 ATP12A ATP4A S100A8
45 cryoglobulinemia 10.4 CCK CXCL8 SST
46 medullary thyroid carcinoma, familial 10.3 CCK GAST SST
47 brucella canis brucellosis 10.3 AREG TLR9 TRPV1
48 male reproductive system disease 10.3 CCK GAST MLN
49 medullomyoblastoma 10.3 AREG TLR9 TRPV1
50 iris mixed cell melanoma 10.3 CCK GAST HRH2 SST

Graphical network of the top 20 diseases related to Stomach Disease:

Diseases related to Stomach Disease

Symptoms & Phenotypes for Stomach Disease

UMLS symptoms related to Stomach Disease:

abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, signs and symptoms, digestive, stomach ache, gastrointestinal gas

MGI Mouse Phenotypes related to Stomach Disease:

id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.65 AREG ATP12A ATP4A GAST GHRL HRH2
2 homeostasis/metabolism MP:0005376 9.47 AREG ATP12A ATP4A CCK GAST GHRL

Drugs & Therapeutics for Stomach Disease

Drugs for Stomach Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 918)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
2 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1
Pravastatin Approved Phase 4 81093-37-0 54687
Domperidone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 57808-66-9 3151
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
Dexlansoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 138530-94-6, 103577-45-3 9578005
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103577-45-3 3883
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
Mianserin Approved Phase 4 24219-97-4 4184
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1 102625-70-7 4679
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
15 lanreotide Approved Phase 4,Phase 2,Phase 1 108736-35-2
Somatostatin Approved Phase 4,Phase 3,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 26787-78-0 33613 2171
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1 443-48-1 4173
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 117976-89-3 5029
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
Citalopram Approved Phase 4,Phase 2,Phase 3 59729-33-8 2771
Reboxetine Approved, Investigational Phase 4 98769-81-4, 71620-89-8 123628 65856
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
Benzocaine Approved Phase 4,Phase 2,Phase 3 1994-09-7, 94-09-7 2337
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2 83150-76-9 383414 6400441
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
Famotidine Approved Phase 4,Phase 3,Phase 2,Phase 1 76824-35-6 3325
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 141758-74-9 15991534
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3 616-91-1 12035
Propranolol Approved, Investigational Phase 4,Phase 3 525-66-6 4946
Sucralfate Approved Phase 4,Phase 2 54182-58-0
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
Levodopa Approved Phase 4,Phase 3,Phase 2 59-92-7 6047
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
Trastuzumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 180288-69-1 9903
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
Insulin Aspart Approved Phase 4 116094-23-6 16132418
Insulin Detemir Approved Phase 4 169148-63-4 5311023
Insulin Glargine Approved Phase 4,Phase 2 160337-95-1

Interventional clinical trials:

(show top 50) (show all 2984)

id Name Status NCT ID Phase Drugs
1 Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
2 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
3 Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer Unknown status NCT01038154 Phase 4 Pravastatin
4 Prucalopride Versus Placebo in Gastroparesis Unknown status NCT02510976 Phase 4 prucalopride;placebo
5 Effects and Mechanism of Mosapride Citrate on Diabetic Gastroparesis Unknown status NCT02264587 Phase 4 Mosapride;domperidone
6 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4 esomeprazole
7 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4 lansoprazole;esomeprazole
8 Mirtazapine Versus Placebo in Functional Dyspepsia Unknown status NCT01240096 Phase 4 Mirtazapine
9 Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD? Unknown status NCT01621451 Phase 4 aspirin and/or clopidogrel;aspirin and/or clopidogrel
10 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
11 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
12 Gastrectomy Plus Prophylactic Cholecystectomy in Gastric Cancer Surgery Unknown status NCT00757640 Phase 4
13 Perioperative Application of Omega-3 Polyunsaturated Fatty Acids in Gastric Cancer Patients Unknown status NCT01910948 Phase 4 omega-3 polyunsaturated fatty acids
14 Preoperative Chemotherapy With Bevacizumab For Potentially Resectable Gastric Cancer With Liver Metastasis Unknown status NCT01962376 Phase 4 Oxaliplatin;Capecitabine;Oxaliplatin;Capecitabine;Bevacizumab
15 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
16 Early Jejunostomy Nutrition Minimizes Time to Chemotherapy Unknown status NCT01766765 Phase 4
17 Parenteral Fish Oil in Major Laparoscopic Abdominal Surgery Unknown status NCT01819961 Phase 4 MCT/LCT and fish oil;MCT/LCT
18 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4 oral esomeprazole 20 mg twice daily;oral esomeprazole 20 mg once daily
19 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
20 Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance Unknown status NCT01503476 Phase 4
21 The Orange-III Trial: Optimised Recovery With Movicol® Preoperatively Within an Enhanced Recovery Programme Unknown status NCT01429779 Phase 4 Movicol
22 Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
23 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
24 Gastric Functions & Proton Pump Inhibitor( PPI) Study Unknown status NCT00951431 Phase 4 Esomeprazole;Placebo
25 Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2 Unknown status NCT00473733 Phase 4
26 Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions Unknown status NCT02118844 Phase 4 rocuronium
27 Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding Unknown status NCT00966355 Phase 4 Terlipressin;Somatostatin;Octreotide
28 Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia Unknown status NCT00978159 Phase 4 esomeprazole;Famotidine
29 Study of Comparison the Treatment Effect Between Gastric Bypass and Exenatide in Type 2 Diabetes Unknown status NCT01435980 Phase 4 Exenatide
30 Efficacy of Acetylcysteine-containing Triple Therapy in the First Line of Helicobacter Pylori Infection Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
31 Clinical Study of Laparoscopic Non Banded Vertical Gastroplasty in Bariatric Surgery Unknown status NCT02050477 Phase 4
32 Prospective Random Comparing Study on EUS-guided Pseudocyst Drainage by Naso-pancreatic Tube and Stents Unknown status NCT01585662 Phase 4
33 Prospective Randomized Trials of Gastric Bypass Surgery in Patients With Type II Diabetes Mellitus Unknown status NCT00540462 Phase 4
34 Randomized Double-Blind Clinical Trial of Rebamipide vs Esomeprazole in the Treatment of NSAID-induced Gastropathy Completed NCT00641004 Phase 4 Rebamipide and Esomeprazole
35 Effect of Early Oral Triple Viable Bifidobacterium Intestinal Flora in Preterm Completed NCT02060084 Phase 4 a control group;a probiotic-supplemented group
36 High Dose PPI Triple Therapy Versus Sequential Therapy for Helicobacter Pylori Eradication Completed NCT01888237 Phase 4 Double dose of PPI;sequence of drug use
37 Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
38 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
39 Clinical Effect of Rebamipide on Chronic Gastritis Completed NCT02393430 Phase 4 Rebamipide
40 Efficacy and Safety of Eupasidin-s Tab.(EUPASIDIN-S) in Gastritis Patients Completed NCT02356679 Phase 4 Eupasidin-s Tab;Stillen Tab.
41 A Study to Evaluate the Efficacy and of Stillen Tab. and to Demonstrate the Non-inferiority of Stillen Tab. Completed NCT01817556 Phase 4 Stillen Tab.;Mucosta Tab.
42 To Evaluate the Efficacy and Safety of Vitamin B12 Contains Extract of Lamb's Stomach in Treatment of Chronic Atrophic Gastritis (CAG) Completed NCT01474044 Phase 4 Gastropylor Complex Capsules
43 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients Completed NCT02648659 Phase 4 Ilaprazole;Amoxicillin;Clarithromycin;Metronidazole
44 Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy Completed NCT00272467 Phase 4 Rebamipide;Omeprazole
45 Limited Access Protocol for the Use of Oral Cisapride Completed NCT02524496 Phase 4
46 Effect of Digene Total (Buffered Pantoprazole) on 24 Hour Gastric Potential Hydrogen (pH) in Patients From Acid Peptic Disorder After Single and Repeated Dosing. Completed NCT01214408 Phase 4 Buffered pantoprazole;Buffered pantoprazole
47 Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis Completed NCT00492622 Phase 4 Immediate-release omeprazole;Delayed-release omeprazole
48 Ulcer Prevention Study in Post Gastric Bypass Patients Completed NCT00557349 Phase 4 Omeprazole;Famotidine
49 The Effect of Perioperative Intravenous Magnesium on Pain After Endoscopic Submucosal Dissection for Gastric Neoplasm: Prospective Randomized Double-blind Placebo Controlled Study Completed NCT02235246 Phase 4 Magnesium Sulfate;Normal saline
50 Improving Complete Endoscopic Mucosal Resection (EMR) of Colorectal Neoplasia Completed NCT01471756 Phase 4

Search NIH Clinical Center for Stomach Disease

Cochrane evidence based reviews: stomach diseases

Genetic Tests for Stomach Disease

Anatomical Context for Stomach Disease

MalaCards organs/tissues related to Stomach Disease:

Liver, Testes, Lung, Colon, Lymph Node, Kidney, T Cells

Publications for Stomach Disease

Articles related to Stomach Disease:

id Title Authors Year
[Stomach disease and ghrelin]. ( 15506414 )
A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. ( 8614622 )
Some aspects of gastric secretory tests in dogs for diagnostic purposes in two selected cases of stomach disease. ( 6860926 )
The gastrocamera in the diagnosis of stomach disease. ( 5694513 )

Variations for Stomach Disease

Expression for Stomach Disease

Search GEO for disease gene expression data for Stomach Disease.

Pathways for Stomach Disease

GO Terms for Stomach Disease

Cellular components related to Stomach Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCK CXCL8 GAST GHRL GIF MLN
2 extracellular space GO:0005615 9.32 AREG ATP4A CCK CXCL8 GAST GHRL

Biological processes related to Stomach Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 prostaglandin biosynthetic process GO:0001516 9.43 PTGS1 PTGS2
2 inflammatory response GO:0006954 9.43 CXCL8 PTGS1 PTGS2 S100A8 TLR9 TRPV1
3 cellular response to ATP GO:0071318 9.4 PTGS2 TRPV1
4 response to molecule of bacterial origin GO:0002237 9.37 CXCL8 TLR9
5 response to organonitrogen compound GO:0010243 9.33 PTGS2 SST TRPV1
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
7 G-protein coupled receptor signaling pathway GO:0007186 9.28 AREG CXCL8 GAST GHRL HRH2 HTR4
8 cyclooxygenase pathway GO:0019371 9.26 PTGS1 PTGS2

Molecular functions related to Stomach Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 9.16 ATP12A ATP4A
3 hormone activity GO:0005179 9.02 CCK GAST GHRL MLN SST
4 prostaglandin-endoperoxide synthase activity GO:0004666 8.96 PTGS1 PTGS2

Sources for Stomach Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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