MCID: STM007
MIFTS: 51

Stomatitis malady

Summaries for Stomatitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Stomatitis is inflammation in the mouth. The term refers to any inflammatory process affecting the... more...

MalaCards: Stomatitis is related to denture stomatitis and ulcerative stomatitis. An important gene associated with Stomatitis is TP63 (tumor protein p63), and among its related pathways are Influenza A and TRAF Pathway. The drugs sucralfate and carbamide peroxide and the compounds serine and rantes have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotype immune system.

Aliases & Classifications for Stomatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

stomatitis 8 10 45 61


External Ids:

Disease Ontology8 DOID:9637
MeSH35 D013280
NCIt40 C26887

Related Diseases for Stomatitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Stomatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1denture stomatitis31.5PPP6R1, STATH, CST1, ALLC
2ulcerative stomatitis31.1TP63
3lichen planus30.3CXCR3, MX1
4oral lichen planus30.3CXCR3, TP63
5measles30.2MX1
6hepatitis c30.1CXCR3, MX1, IRF7, TNF, CD69
7hepatitis b30.1MX1
8newcastle disease30.1IRF3
9rabies30.0MX1
10arthritis29.7MX1, CD69, TNF, MVK, CXCR3
11familial mediterranean fever29.7MVK, TNF
12aphthous stomatitis11.2
13pharyngitis10.7
14behcet's disease10.3
15n syndrome10.3
16periodic fever, aphthous stomatitis, pharyngitis and adenitis10.3
17noma10.2
18adenocarcinoma10.2
19celiac disease10.2
20vaccinia10.1
21pemphigus10.1
22adult syndrome10.1
23avian influenza10.1
24lymphocytic choriomeningitis10.1
25ariboflavinosis10.1
26oral candidiasis10.1
27hepatitis c virus10.1
28paraneoplastic pemphigus10.1
29st. louis encephalitis10.0
30herpes zoster10.0
31pernicious anemia10.0
32mumps10.0
33squamous cell carcinoma10.0
34dent's disease10.0
35char syndrome10.0
36sutton disease 210.0
37young syndrome10.0
38glucagonoma10.0
39leukoplakia10.0
40oral leukoplakia10.0
41atopy10.0
42periodic fever, familial10.0
43discoid lupus erythematosus10.0
44viral infectious disease10.0IRF7, IRF3, CXCR3, TNF, TBK1, MX1
45influenza10.0MX1, CXCR3, ERVW-1, IRF3, MX2, CD69
46ipex syndrome10.0CD69, TNF, IRF3, TBK1, CXCR3, ERVW-1
47rheumatoid arthritis10.0ERVW-1, TNF, IRF3, CXCR3, CD69, CFI
48burkitt's lymphoma10.0IRF7, CD69, ERVW-1, CXCR3, IRF3, MX1
49melanoma10.0CXCR3, TNF, RNPEP, CFI, MX1, TP63
50systemic lupus erythematosus10.0CFI, MX1, TNF, CD69, CXCR3

Graphical network of the top 20 diseases related to Stomatitis:



Diseases related to stomatitis

Clinical Features for Stomatitis

Drugs & Therapeutics for Stomatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Stomatitis

Drug clinical trials:

Search ClinicalTrials for Stomatitis

Search NIH Clinical Center for Stomatitis

Search CenterWatch for Stomatitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Stomatitis

Anatomical Context for Stomatitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Stomatitis:

33
Bone marrow, Brain, Heart, Small intestine, Colon, Lung, Salivary gland, Breast, Skin, Prostate, Tonsil, Monocytes, Nk cells, T cells, B cells, Endothelial, Tongue

Animal Models for Stomatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Stomatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8TP63, MX2, IL12A, CXCR3, CD69, TBK1

Publications for Stomatitis

Sources:
51PubMed
See all sources

Articles related to Stomatitis:

(show top 50)    (show all 1145)
idTitleAuthorsYear
1
N-terminal phosphorylation of phosphoprotein of vesicular stomatitis virus is required for preventing nucleoprotein from binding to cellular RNAs and for functional template formation. (23283948)
2013
2
There is limited evidence that topical lavender oil is effective for palliative treatment of recurrent aphthous stomatitis. (23773464)
2013
3
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus. (23589850)
2013
4
Elevated serum IgE in recurrent aphthous stomatitis and associations with disease characteristics. (23730959)
2013
5
Stability and inactivation of vesicular stomatitis virus, a prototype rhabdovirus. (22995872)
2013
6
Bovine papular stomatitis affecting dairy cows and milkers in midwestern Brazil. (22362531)
2012
7
Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. (22238308)
2012
8
Down-regulation of viral replication by lentiviral-mediated expression of short-hairpin RNAs against vesicular stomatitis virus ribonuclear complex genes. (22640779)
2012
9
Necrotic ulcerative spirochaetal stomatitis in outdoor pigs. (21742700)
2011
10
Assessment of Candida species colonization and denture-related stomatitis in complete denture wearers. (20795762)
2011
11
Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats. (21802033)
2011
12
The prevalence of denture stomatitis and its predisposing conditions in an older Greek population. (20082642)
2011
13
Vesicular stomatitis virus oncolytic treatment interferes with tumor-associated dendritic cell functions and abrogates tumor antigen presentation. (21917977)
2011
14
On the road to discovery in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. (21810991)
2011
15
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
16
Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. (20173724)
2010
17
Denture stomatitis and its risk indicators in south Brazilian older adults. (19545319)
2010
18
The efficacy of a paste containing Myrtus communis (Myrtle) in the management of recurrent aphthous stomatitis: a randomized controlled trial. (19306024)
2010
19
Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-beta for use in malignant pleural mesothelioma: heterogeneity in interferon responsiveness defines potential efficacy. (19715403)
2010
20
Safety studies on intrahepatic or intratumoral injection of oncolytic vesicular stomatitis virus expressing interferon-beta in rodents and nonhuman primates. (19911974)
2010
21
Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells. (19906910)
2010
22
Transduction of Schistosoma japonicum schistosomules with vesicular stomatitis virus glycoprotein pseudotyped murine leukemia retrovirus and expression of reporter human telomerase reverse transcriptase in the transgenic schistosomes. (20692298)
2010
23
A study of the relationship between Helicobacter pylori and recurrent aphthous stomatitis using a urea breath test. (19142251)
2009
24
Structure of the vesicular stomatitis virus nucleocapsid in complex with the nucleocapsid-binding domain of the small polymerase cofactor, P. (19571006)
2009
25
Management of stomatitis. (19752255)
2009
26
Mixed Candida albicans and Candida glabrata populations associated with the pathogenesis of denture stomatitis. (18793360)
2008
27
Is nickel in amalgam capable of aphthous stomatitis in a patient reacting to nickel? (19049947)
2008
28
Parapharyngeal abscess in a previously tonsillectomised child with periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome: first reported case. (18036284)
2008
29
Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis. (16792733)
2006
30
Etiology and Management of Recurrent Aphthous Stomatitis. (12760815)
2003
31
Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF-alpha, TNF-beta and the vitamin D receptor: no association detected. (12477062)
2002
32
Lack of association between Streptococcus oralis and recurrent aphthous stomatitis. (10678713)
2000
33
Syndrome of Periodic Fever, Aphthous stomatitis, Pharyngitis, and Adenitis (PFAPA)--what it isn't. What is it? (10393593)
1999
34
Recurrent aphthous stomatitis in BehAset's disease: clinical features and correlation with systemic disease expression and severity. (10226940)
1999
35
The association of yeasts and denture stomatitis with behavioral and biologic factors. (9431530)
1997
36
Search for human herpesvirus 6, human cytomegalovirus and varicella zoster virus DNA in recurrent aphthous stomatitis tissue. (9176795)
1997
37
Minor recurrent aphthous stomatitis: Clinic characteristics hematologic deficiencies in 60 patients. (11505226)
1996
38
Prevention of recurrent aphthous stomatitis with colchicine: an open trial. (8077473)
1994
39
Smokeless tobacco use prevents aphthous stomatitis. (1408021)
1992
40
Oral candidal infection and denture stomatitis: a comprehensive review. (1740572)
1992
41
Recurrent aphthous stomatitis. A study of the clinical characteristics of lesions in 93 cases. (1941657)
1991
42
Clinical evaluation of benzydamine, chlorhexidine, and placebo mouthwashes in the management of recurrent aphthous stomatitis. (3469601)
1987
43
Ulcerative stomatitis and subcutaneous granulomas caused by Mycobacterium chelonei in a boa constrictor. (3505951)
1986
44
In situ characterization of the inflammatory cell infiltrates of hyperplastic denture stomatitis. (3526801)
1986
45
Glycyrrhizin as a vehicle for the application of triamcynolone in the treatment of recurrent aphthous stomatitis. (6522412)
1984
46
Quantitative distribution of inflammatory cells in recurrent aphthous stomatitis. (6937488)
1980
47
Letter: Treatment of recurrent aphthous stomatitis and herpes with levamisole. (4611586)
1974
48
MORE OBSERVATIONS ON RELIEF OF APHTHOUS STOMATITIS ON RESUMPTION OF CIGARETTE SMOKING. A REPORT OF THREE CASES. (14229748)
1964
49
Vesicular stomatitis and exanthem. A syndrome associated with Coxsackie virus, type A16. (13765313)
1961
50
Treatment of aphthous stomatitis with aureomycin mouthwash. (14359576)
1955

Genetic Variations for Stomatitis

Expression for genes affiliated with Stomatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stomatitis

Search GEO for disease gene expression data for Stomatitis.

Pathways for genes affiliated with Stomatitis

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems, 4Cell Signaling Technology, 54Reactome
See all sources

Pathways related to Stomatitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TNF, IRF3, IRF7, MX1, IL12A, TBK1
2
Hide members
10.7TNF, IL12A, TBK1, IRF7, IRF3
3
Hide members
10.7TNF, IRF3, IRF7, TBK1, IL12A
4
Hide members
10.6TBK1, IRF7, TNF, IRF3
510.6IRF3, TBK1, IRF7, TNF
610.6IRF3, TNF, TBK1, IRF7
7
Immune response IFN alpha/beta signaling pathway
Hide members
10.6IRF7, MX1, MX2, IRF3
8
Hide members
10.6IRF3, IRF7, MX1, MX2
9
Hide members
10.6IRF7, TNF, IRF3
10
Hide members
10.6IRF7, TNF, IRF3
1110.6IL12A, IRF3, TNF
12
Hide members
10.6TNF, IRF3, TBK1
13
Hide members
10.6IRF7, IRF3, TBK1
14
Hide members
10.6TBK1, IRF7, IRF3
15
Hide members
10.6IRF3, IRF7, TBK1
16
Hide members
10.6IRF3, IRF7, TBK1
17
Hide members
10.5TBK1, IRF3
1810.5IRF3, TBK1

Compounds for genes affiliated with Stomatitis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR
See all sources

Compounds related to Stomatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4511.0ERVW-1, TNF, IRF7, MX1, MVK, CXCR3
2rantes4510.9ERVW-1, MX1, CXCR3, TBK1, IRF7, IRF3
3poly(i-c)4510.9MX1, CD69, TBK1, IRF7, IRF3, TNF
4ifn-alpha4510.8IRF3, IRF7, CXCR3, MX1
5lipid4510.7ERVW-1, CFI, MX1, CD69, TNF, MVK
6polyinosinic-polycytidylic acid4510.7IRF3, TNF, IRF7
72,5-oligoadenylate4510.7IRF7, TNF, MX1
8ly2940024510.6CD69, IRF3, CXCR3, TNF
9anakinra45 1111.5TNF, MVK
10isopentenyl diphosphate45 2911.3CD69, MVK

GO Terms for genes affiliated with Stomatitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Stomatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00961511.0IRF7, TNF, TBK1, IL12A, MX1
2type I interferon-mediated signaling pathwayGO:06033710.9MX2, IRF3, IRF7, MX1
3positive regulation of interferon-alpha productionGO:03272710.9TBK1, IRF3, IRF7
4positive regulation of interferon-beta productionGO:03272810.9TBK1, IRF7, IRF3
5defense response to Gram-positive bacteriumGO:05083010.9TBK1, TNF, IL12A
6cytokine-mediated signaling pathwayGO:01922110.8MX2, IRF3, IRF7, MX1
7MDA-5 signaling pathwayGO:03953010.8IRF3, IRF7
8positive regulation of type I interferon productionGO:03248110.8IRF7, TBK1, IRF3
9type I interferon biosynthetic processGO:04535110.8IRF3, IRF7
10TRIF-dependent toll-like receptor signaling pathwayGO:03566610.7IRF3, TBK1, IRF7
11positive regulation of type I interferon-mediated signaling pathwayGO:06034010.7IRF7, IRF3
12MyD88-independent toll-like receptor signaling pathwayGO:00275610.7IRF3, IRF7, TBK1
13toll-like receptor 3 signaling pathwayGO:03413810.7TBK1, IRF7, IRF3
14toll-like receptor 4 signaling pathwayGO:03414210.6IRF3, IRF7, TBK1
15toll-like receptor signaling pathwayGO:00222410.6TBK1, IRF3, IRF7
16innate immune responseGO:04508710.6IRF3, IRF7, CFI, TBK1, MX1
17apoptotic processGO:00691510.4CXCR3, MX1, TP63, IRF3, TNF

Molecular functions related to Stomatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.7TP63, TBK1, IRF3, TNF, MVK

Products for genes affiliated with Stomatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Stomatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet