Stomatitis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Stomatitis

Sources:
⁶⁴Wikipedia, ³²MalaCards
See all sources

Wikipedia:⁶⁴ Stomatitis is inflammation of the mouth and lips. It refers to any inflammatory process affecting the... more...

MalaCards based summary: Stomatitis is related to behcet's disease and familial mediterranean fever. An important gene associated with Stomatitis is TP63 (tumor protein p63), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Malaria. The drugs sucralfate and carbamide peroxide and the compounds imiquimod and mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and colon, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Stomatitis

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁴⁴Novoseek, ⁶¹UMLS, ⁵⁶SNOMED-CT, ³⁴MeSH, ³⁹NCIt
See all sources

Stomatitis, Aliases & Descriptions:

Name: Stomatitis ⁹ ¹¹ ⁴⁴ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases

External Ids:

Disease Ontology⁹ DOID:9637

MeSH³⁴ D013280

SNOMED-CT⁵⁶ 95361005, 196527002, 155660009 61170000, more

NCIt³⁹ C26887

UMLS⁶¹ C0038362

Related Diseases for Stomatitis

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Stomatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 159)

id	Related Disease	Score	Top Affiliating Genes
1	behcet's disease	30.6	TNF, MEFV
2	familial mediterranean fever	30.1	MEFV, TNF
3	hepatitis c	29.8	MX1, IRF7, TNF
4	multiple sclerosis	29.6	TNF, CCR1, MX1
5	melanoma	29.6	TNF, TP63, MEFV, CCR1, MX1
6	arthritis	29.4	MX1, CCR1, MEFV, TNF
7	aphthous stomatitis	11.2
8	denture stomatitis	11.0
9	ulcerative stomatitis	10.8
10	pharyngitis	10.7
11	cervicitis	10.6
12	cervical adenitis	10.6
13	periodic fever, aphthous stomatitis, pharyngitis and adenitis	10.5
14	blindness	10.5
15	palindromic rheumatism	10.4	MEFV
16	erysipelas	10.4	MEFV
17	glossitis	10.3
18	influenza	10.3
19	noma	10.3
20	encephalitis	10.3
21	gingivitis	10.3
22	hiv-1	10.3
23	lichen planus	10.3
24	adenocarcinoma	10.3
25	cheilitis	10.3
26	herpes simplex	10.3
27	periodic fever, familial, autosomal dominant	10.2	TNF, MEFV
28	celiac disease	10.2
29	hepatitis	10.2
30	blau syndrome	10.2	MEFV, TNF
31	geographic tongue	10.2
32	pemphigus	10.2
33	neuronitis	10.2
34	measles	10.2
35	vaccinia	10.2
36	central nervous system disease	10.2
37	nervous system disease	10.2
38	pancreatitis	10.2
39	periodontitis	10.2
40	oral lichen planus	10.2
41	immunoglobulin a vasculitis	10.1	MEFV, MX1
42	diabetes mellitus	10.1
43	hepatitis b	10.1
44	newcastle disease	10.1
45	oral candidiasis	10.1
46	necrotizing ulcerative gingivitis	10.1
47	avian influenza	10.1
48	lymphocytic choriomeningitis	10.1
49	ariboflavinosis	10.1
50	dermatitis	10.1

Graphical network of the top 20 diseases related to Stomatitis:

Symptoms for Stomatitis

Drugs & Therapeutics for Stomatitis

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Stomatitis

Search NIH Clinical Center for Stomatitis

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

carbamide peroxide

sucralfate

Genetic Tests for Stomatitis

Anatomical Context for Stomatitis

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Stomatitis:

³²

T cells, Testes, Colon, Neutrophil, Brain, Tongue, Skin, Bone, Prostate, Endothelial, Heart, Breast, Monocytes, Bone marrow, Lung, Tonsil, B cells

Animal Models for Stomatitis or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Stomatitis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	8.2	TNF, TP63, IRF7, MEFV, CCR1, IL12A
2	immune system phenotype	MP:0005387	7.6	TNF, ISG15, TP63, IRF7, MEFV, CCR1

Publications for Stomatitis

Sources:
⁵¹PubMed
See all sources

Articles related to Stomatitis:

(show top 50) (show all 1192)

id	Title	Authors	Year
1	Transmitted/Founder simian immunodeficiency virus envelope sequences in vesicular stomatitis and semliki forest virus vector immunized rhesus macaques. (25360552)	Gambhira R.... Marx P.A.	2014
2	Antifungal medications or disinfectants for denture stomatitis. (24971864)	Lalla R.V.... Dongari-Bagtzoglou A.	2014
3	Experimental simulation of radio- and chemoradio stomatitis in rats. (23658931)	Antushevich A.A.... Polevay L.P.	2013
4	Assessment of immediate pain relief with laser treatment in recurrent aphthous stomatitis. (23622766)	Prasad R S.... Pai A.	2013
5	Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study. (24268387)	El Khouli A.M.... El-Gendy E.A.	2013
6	Bovine papular stomatitis affecting dairy cows and milkers in midwestern Brazil. (22362531)	de Sant'Ana F.J.... Flores E.F.	2012
7	Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription. (23028327)	Rajani K.R.... Lyles D.S.	2012
8	A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)	Cantarini L.... Frediani B.	2012
9	Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). (22972085)	Brocklehurst P.... Yates J.M.	2012
10	Elucidating role of salivary proteins in denture stomatitis using a proteomic approach. (23041753)	Bencharit S.... Offenbacher S.	2012
11	A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion. (21680501)	Stanifer M.L.... Whelan S.P.	2011
12	Domestic cattle as a non-conventional amplifying host of vesicular stomatitis New Jersey virus. (21133963)	Smith P.F.... Mead D.G.	2011
13	Lesion development and replication kinetics during early infection in cattle inoculated with Vesicular stomatitis New Jersey virus via scarification and black fly (Simulium vittatum) bite. (20858740)	Reis J.L.... Brown C.C.	2011
14	Distinct patterns of stomatitis with concurrent cetuximab and radiotherapy for head and neck squamous cell carcinoma. (21852185)	Pryor D.I.... Porceddu S.V.	2011
15	Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)	Burton M.J.... Ramsden J.D.	2010
16	Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. (20173724)	Momen-Beitollahi J.... Sahebjamee M.	2010
17	Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. (19957332)	Zhang K.X.... Rennie P.S.	2010
18	Ageing exacerbates damage of systemic and salivary neutrophils from patients presenting Candida-related denture stomatitis. (19327169)	Gasparoto T.H.... Lara V.S.	2009
19	Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. (19390604)	Cureton D.K.... Whelan S.P.	2009
20	Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro. (16507098)	Simmons A.... Davey R.A.	2006
21	Effect of low-level laser therapy on Candida albicans growth in patients with denture stomatitis. (15954824)	Maver-Biscanin M.... Jerolimov V.	2005
22	Characterization of the chicken PKR: polymorphism of the gene and antiviral activity against vesicular stomatitis virus. (15070037)	Ko J.H.... Agui T.	2004
23	Results of double-blind placebo-controlled challenge with nickel salts in patients affected by recurrent aphthous stomatitis. (12915773)	Pacor M.L.... Corrocher R.	2003
24	IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS). (12140751)	Bazrafshani M.R.... Thornhill M.H.	2002
25	Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. (11106761)	von Kobbe C.... Izaurralde E.	2000
26	Oral and maxillofacial pathology case of the month. Recurrent aphthous stomatitis--herpetiform type. (11857822)	Binnie W.H.	2000
27	Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)	Padeh S.... Passwell J.H.	1999
28	Chronic ulcerative stomatitis. (9292078)	WAPrle B.... Meurer M.	1997
29	Existence of Candida albicans and microorganisms in denture stomatitis patients. (9372471)	Kulak Y.... Kazazoglu E.	1997
30	Decreased levels of salivary prostaglandin E2 and epidermal growth factor in recurrent aphthous stomatitis. (8850647)	Wu-Wang C.Y.... Wang S.L.	1995
31	Denture stomatitis and ABO blood types. (1800738)	Nikawa H.... Hamada T.	1991
32	Aphthous stomatitis and its management. (1807480)	Santis H.R.	1991
33	Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (2161946)	Pavlovic J.... Staeheli P.	1990
34	Characterization of a macrophage-tropic HIV strain that does not alter macrophage cytokine production yet protects macrophages from superinfection by vesicular stomatitis virus. (2171598)	Kornbluth R.S.... Richman D.D.	1990
35	Immunological and histological studies on denture stomatitis in children: a pilot study. (2478985)	Shimizu F.... Kamiyama K.	1988
36	Candidal antibodies in patients undergoing treatment for denture stomatitis. (3298628)	FouchAc M.H.... Coogan M.M.	1987
37	Prevalence and persistence of different strains of Candida albicans in treatment of denture stomatitis. (2985776)	Watkinson A.C.... Warnock D.W.	1985
38	Recurrent aphthous stomatitis. (4025106)	Burns R.A.... Davis W.J.	1985
39	Recurrent aphthous stomatitis: review of the literature. (6214531)	Stokes R.W.... Koprince D.	1982
40	Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)	Kuno G.	1981
41	Effect of nystatin in the treatment of denture stomatitis. (6936771)	Bergendal T.... Isacsson G.	1980
42	Yeast colonization in the oral cavity and feces in patients with denture stomatitis. (371327)	Bergendal T.... Nord C.E.	1979
43	Double-blind study of levamisole in aphthous stomatitis. (105099)	Kaplan B.... Pinnell S.R.	1978
44	Evaluation of the therapeutic effect of levamisole in treatment of recurrent aphthous stomatitis. (105100)	Gier R.E.... Hardman P.K.	1978
45	Aphthous stomatitis as a featuring syndrome of emotional stress in dental treatment. (1076577)	Kaufman A.Y.	1976
46	Incidence of immediate and delayed hypersensitivity to Candida albicans in denture stomatitis. (4933599)	Davenport J.C.... Wilton J.M.	1971
47	Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic, and hypersensitivity aspects. (5952294)	Graykowski E.A.... Stanley H.R.	1966
48	Antihistaminic agents in the treatment of recurrent aphthous stomatitis. (13037294)	ZEGARELL E.V.... KUTSCHER A.H.	1953
49	Glossitis and stomatitis due to penicillin lozenges and troches. (21016496)	PHILLIPS E.	1946
50	Ulcerative Stomatitis in Children. (19975517)	Rose S.F.	1911

Genes related to Stomatitis

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Stomatitis:

(show all 12)

- Elite gene

id	Symbol	Description	Score	Implication
1	TP63	tumor protein p63	21.02	GeneCards inferred via : Publications, Disorders, Gene name (show sections)
2	TNF	tumor necrosis factor	19.14	GeneCards inferred via : Publications (show sections)
3	FGF20	fibroblast growth factor 20	17.45	GeneCards inferred via : Disorders (show sections)
4	ISG15	ISG15 ubiquitin-like modifier	15.78	GeneCards inferred via : Disorders (show sections)
5	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	14.11	GeneCards inferred via : Publications (show sections)
6	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	12.45	GeneCards inferred via : Publications, Disorders (show sections)
7	CCR1	chemokine (C-C motif) receptor 1	10.78	GeneCards inferred via : Publications (show sections)
8	IRF7	interferon regulatory factor 7	9.11	GeneCards inferred via : Publications, Disorders (show sections)
9	MEFV	Mediterranean fever	7.45	GeneCards inferred via : Publications (show sections)
10	VDI	vesicular stomatitis virus defective interfering particle suppression	5.91	GeneCards inferred via : Publications, Gene name, Functions (show sections)
11	CST1	cystatin SN	4.11	GeneCards inferred via : Disorders (show sections)
12	ELOF1	elongation factor 1 homolog (S. cerevisiae)	2.45	GeneCards inferred via : Disorders (show sections)

Products for genes related to Stomatitis disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	11	-	11	11
2	Novus Biologicals	9	10	11	-

Variations for Stomatitis

Expression for genes affiliated with Stomatitis

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Stomatitis

Search GEO for disease gene expression data for Stomatitis.

Pathways for genes affiliated with Stomatitis

Sources:
⁴⁹PathCards, ⁵³R&D Systems, ³⁰KEGG, ⁵²QIAGEN, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ⁵⁹Thomson Reuters
See all sources

Pathways related to Stomatitis according to GeneCards/GeneDecks:

(show all 17)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³	9.8	IL12A, TNF
2	Malaria³⁰	9.8	TNF, IL12A
3	MSP-RON Signaling⁵²	9.8	TNF, IL12A
4	Cytokine Network⁵²	9.8	TNF, IL12A
5	African trypanosomiasis³⁰	9.8	TNF, IL12A
6	Legionellosis³⁰	9.8	TNF, IL12A
7	Th1 Differentiation⁵³ Show member pathways IL27-mediated signaling events³⁷	9.8	TNF, IL12A
8	Apoptosis⁵⁴ Show member pathways Apoptosis Modulation and Signaling³⁷ Apoptosis³⁷	9.5	TNF, TP63, IRF7
9	TRAF Pathway⁵² Show member pathways TNF Superfamily Pathway⁵² Toll-Like Receptors Pathway⁵²	9.4	IL12A, TNF, IRF7
10	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	9.4	TNF, IL12A, IRF7
11	Interferon Signaling⁵⁴ Show member pathways ISG15 antiviral mechanism⁵⁴ Cytokine Signaling in Immune system⁵⁴ Regulation of IFNG signaling⁵⁴ Interferon gamma signaling⁵⁴ Antiviral mechanism by IFN-stimulated genes⁵⁴	9.3	ISG15, IRF7, MX1
12	Immune response IFN alpha beta signaling pathway⁵⁹ Show member pathways Regulation of IFNA signaling⁵⁴ Interferon alpha/beta signaling⁵⁴	9.3	MX1, ISG15, IRF7
13	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	9.1	IL12A, TNF, CCR1, FGF20
14	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	9.1	TNF, CCR1, IL12A, FGF20
15	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	9.1	TNF, CCR1, IL12A, FGF20
16	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways⁵⁴ Show member pathways RIG-I-like receptor signaling pathway³⁰ TRAF6 mediated IRF7 activation⁵⁴ TRAF3-dependent IRF activation pathway⁵⁴ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10⁵⁴ Negative regulators of RIG-I/MDA5 signaling⁵⁴	9.1	IL12A, ISG15, TNF, IRF7
17	Influenza A³⁰ Show member pathways Measles³⁰ Herpes simplex infection³⁰	9.0	IL12A, TNF, MX1, IRF7

Compounds for genes affiliated with Stomatitis

Sources:
⁴⁴Novoseek, ⁶⁰Tocris Bioscience, ²⁹IUPHAR, ¹²DrugBank, ⁵⁰PharmGKB, ²⁵HMDB
See all sources

Compounds related to Stomatitis according to GeneCards/GeneDecks:

(show all 12)

id	Compound	Score	Top Affiliating Genes
1	imiquimod⁴⁴ ⁶⁰ ²⁹ ¹²	13.0	TNF, MX1
2	mycophenolate mofetil⁴⁴ ⁵⁰ ¹²	11.9	IL12A, TNF
3	polyinosinic-polycytidylic acid⁴⁴	9.9	TNF, IRF7
4	neopterin⁴⁴	9.8	MX1, TNF
5	ccl3⁴⁴ ²⁹	10.7	TNF, CCR1
6	poly(i-c)⁴⁴	9.6	IRF7, MX1, TNF
7	ifn-alpha⁴⁴	9.3	MX1, IRF7
8	2,5-oligoadenylate⁴⁴	9.3	MX1, TNF, ISG15, IRF7
9	cycloheximide⁴⁴	9.3	TNF, ISG15, CCR1, MX1
10	retinoic acid⁴⁴ ²⁵	10.2	CCR1, TP63, TNF, ISG15
11	rantes⁴⁴	9.2	TNF, CCR1, MX1, IRF7
12	leucine⁴⁴	8.6	CCR1, MEFV, ELOF1, ISG15, MX1

GO Terms for genes affiliated with Stomatitis

Sources:
¹⁷Gene Ontology
See all sources

Biological processes related to Stomatitis according to GeneCards/GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to type I interferon	GO:034340	10.0	MX1, ISG15
2	defense response to Gram-positive bacterium	GO:050830	9.9	IL12A, TNF
3	positive regulation of osteoclast differentiation	GO:045672	9.9	CCR1, TNF
4	extrinsic apoptotic signaling pathway	GO:097191	9.8	IL12A, TNF
5	negative regulation of gene expression	GO:010629	9.8	TNF, CCR1
6	negative regulation of viral genome replication	GO:045071	9.8	ISG15, TNF, MX1
7	positive regulation of interferon-gamma production	GO:032729	9.7	TNF, IL12A
8	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.6	FGF20, CCR1, TNF
9	type I interferon signaling pathway	GO:060337	9.5	MX1, IRF7, ISG15
10	response to virus	GO:009615	9.3	MX1, IL12A, IRF7, TNF
11	cytokine-mediated signaling pathway	GO:019221	9.2	MX1, ISG15, IRF7, CCR1
12	inflammatory response	GO:006954	9.0	TNF, MEFV, CCR1
13	innate immune response	GO:045087	8.7	IRF7, MX1, FGF20, ISG15, MEFV

Products for genes affiliated with Stomatitis

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Stomatitis

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: STM007 MIFTS: 50	Stomatitis malady Oral diseases category
2 drugs, 12 genes, 17 tissues, 159 related diseases, clinical trials Download this MalaCard Expand all tables

Stomatitis malady