MCID: STM007
MIFTS: 51

Stomatitis malady

Summaries for Stomatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Stomatitis is inflammation of the mouth. The term refers to any inflammatory process affecting the... more...

MalaCards: Stomatitis is related to denture stomatitis and ulcerative stomatitis. An important gene associated with Stomatitis is TP63 (tumor protein p63), and among its related pathways are Influenza A and Toll-like receptor signaling pathway. The drugs sucralfate and carbamide peroxide and the compounds serine and rantes have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and colon, and related mouse phenotype immune system.

Aliases & Classifications for Stomatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

stomatitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:9637
MeSH34 D013280
NCIt39 C26887

Related Diseases for Stomatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Stomatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1denture stomatitis31.5CST1, PPP6R1, STATH, ALLC
2ulcerative stomatitis31.1TP63
3influenza30.4IRF3, CD69, CXCR3, MX1, MX2, ERVW-1
4encephalitis30.3MX1, ERVW-1
5herpes simplex30.3IRF3, IRF7, MX1, ERVW-1
6lichen planus30.3CXCR3, MX1
7hepatitis30.2MX1
8measles30.1MX1
9melanoma30.1TNF, IRF3, RNPEP, CXCR3, MX1, CFI
10hepatitis b30.0MX1
11newcastle disease30.0IRF3
12dermatitis30.0CXCR3
13hepatitis c29.9TNF, IRF7, CD69, CXCR3, MX1
14sarcoma29.9TP63, ERVW-1
15lupus erythematosus29.9MX1
16rabies29.9MX1
17rheumatoid arthritis29.7TNF, IRF3, CD69, CXCR3, CFI, ERVW-1
18arthritis29.7MVK, TNF, CD69, CXCR3, MX1
19psoriasis29.7TNF, CD69, CXCR3, MX1
20multiple sclerosis29.7TNF, CD69, CXCR3, MX1, ERVW-1
21ovarian cancer29.7CFI, CD69
22periodontal disease29.7TNF
23pneumonia29.7TNF
24diarrhea29.7ALLC
25familial mediterranean fever29.7TNF, MVK
26aphthous stomatitis11.2
27pharyngitis10.6
28cervicitis10.5
29cervical adenitis10.5
30glossitis10.3
31noma10.2
32gingivitis10.2
33periodic fever, aphthous stomatitis, pharyngitis and adenitis10.2
34adenocarcinoma10.2
35cheilitis10.2
36celiac disease10.2
37behcet's disease10.2
38vaccinia10.1
39pemphigus10.1
40neuronitis10.1
41adult syndrome10.1
42central nervous system disease10.1
43nervous system disease10.1
44pancreatitis10.1
45periodontitis10.1
46avian influenza10.0
47lymphocytic choriomeningitis10.0
48ariboflavinosis10.0
49oral candidiasis10.0
50hepatitis a10.0

Graphical network of the top 20 diseases related to Stomatitis:



Diseases related to stomatitis

Clinical Features for Stomatitis

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Drugs & Therapeutics for Stomatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stomatitis

Drug clinical trials:

Search ClinicalTrials for Stomatitis

Search NIH Clinical Center for Stomatitis

Search CenterWatch for Stomatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Stomatitis

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Anatomical Context for Stomatitis

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32MalaCards
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MalaCards organs/tissues related to Stomatitis:

32
T cells, Testes, Colon, Brain, Tongue, Skin, Endothelial, Prostate, Bone, Breast, Heart, Lung, Tonsil, Monocytes, B cells, Bone marrow

Animal Models for Stomatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Stomatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8TP63, MX2, IL12A, CXCR3, CD69, TBK1

Publications for Stomatitis

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50PubMed
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Articles related to Stomatitis:

(show top 50)    (show all 1160)
idTitleAuthorsYear
1
Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study. (24268387)
2013
2
A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus. (24232602)
2013
3
Profile of inflammatory mediators in tonsils of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. (23877488)
2013
4
Stability and inactivation of vesicular stomatitis virus, a prototype rhabdovirus. (22995872)
2013
5
Cytopathogenesis of vesicular stomatitis virus is regulated by the PSAP motif of M protein in a species-dependent manner. (23170175)
2012
6
The immune response to a vesicular stomatitis virus vaccine vector is independent of particulate antigen secretion and protein turnover rate. (22345454)
2012
7
Recurrent aphthous stomatitis: topical treatment with minocycline and other evidence-based agents. (23259361)
2012
8
Microbial colonization and their relation with potential cofactors in patients with denture stomatitis. (23151692)
2012
9
Second-site mutations selected in transcriptional regulatory sequences compensate for engineered mutations in the vesicular stomatitis virus nucleocapsid protein. (22875970)
2012
10
Myths and evidence on the link between recurrent aphthous stomatitis and systemic diseases. (22233487)
2012
11
A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing. (21655110)
2011
12
Familial cases of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (21074183)
2011
13
Interferon-induced tetherin restricts vesicular stomatitis virus release in neurons. (21919738)
2011
14
Genital ulcers as an unusual sign of periodic fever, aphthous stomatitis, pharyngotonsillitis, cervical adenopathy syndrome: a novel symptom? (21133994)
2011
15
Severe oesophagitis in an adult bull caused by bovine papular stomatitis virus. (21926143)
2011
16
Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth. (21437961)
2011
17
Influence of hormone supplementation therapy on the incidence of denture stomatitis and on chemiluminescent activity of polymorphonuclear granulocytes in blood of menopausal-aged women. (21147619)
2010
18
The denture hygiene, denture stomatitis and role of dental hygienist. (20624193)
2010
19
A confocal and electron microscopic comparison of interferon beta-induced changes in vesicular stomatitis virus infection of neuroblastoma and nonneuronal cells. (20113203)
2010
20
Safety studies on intrahepatic or intratumoral injection of oncolytic vesicular stomatitis virus expressing interferon-beta in rodents and nonhuman primates. (19911974)
2010
21
Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells. (19906910)
2010
22
Experimental infection of Didelphis marsupialis with vesicular stomatitis New Jersey virus. (20090034)
2010
23
Peripheral immunization blocks lethal actions of vesicular stomatitis virus within the brain. (19726512)
2009
24
Efficacy of fortification of school meals with ferrous glycine phosphate and riboflavin against anemia and angular stomatitis in schoolchildren. (19927606)
2009
25
Management of stomatitis. (19752255)
2009
26
A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. (19419555)
2009
27
The therapeutic and prophylactic role of oral zinc sulfate in management of recurrent aphthous stomatitis (ras) in comparison with dapsone. (18454224)
2008
28
Topical minocycline for managing symptoms of recurrent aphthous stomatitis. (18271771)
2008
29
Prevention of recurrent aphthous stomatitis by efalizumab (Raptiva). (17894741)
2007
30
C-reactive protein in the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. (17937691)
2007
31
Chronic ulcerative stomatitis: clinical, histopathologic, and immunopathologic findings. (14676763)
2003
32
Immunohistochemical localization of type IV collagen and laminin (alpha1) in denture stomatitis. (11168854)
2001
33
Selecting topical and systemic agents for recurrent aphthous stomatitis. (11579786)
2001
34
Vesicular stomatitis virus (VSV) therapy of tumors. (11185959)
2000
35
Interleukin 6, tumor necrosis factor alpha and their soluble receptors in the blood serum of patients with denture stomatitis and fungal infection. (10807050)
2000
36
Recurrent aphthous stomatitis. (9715368)
1998
37
Denture stomatitis secondary to a homemade denture adhesive. (9584739)
1994
38
Cloning and expression of the vesicular stomatitis virus phosphoprotein gene in Escherichia coli: analysis of phosphorylation status versus transcriptional activity. (1848304)
1991
39
Phenotypic identification of T lymphocytes subset in recurrent aphthous stomatitis. (2152028)
1990
40
Chronic ulcerative stomatitis associated with a specific immunologic marker. (2179295)
1990
41
Lack of effect of oral acyclovir on prevention of aphthous stomatitis. (3124046)
1988
42
Treatment of denture stomatitis by a sustained drug-delivery device: a preliminary study. (3216061)
1988
43
Recurrent aphthous stomatitis: otolaryngological interest. (3775127)
1986
44
Glycyrrhizin as a vehicle for the application of triamcynolone in the treatment of recurrent aphthous stomatitis. (6522412)
1984
45
Yeast colonization in the oral cavity and feces in patients with denture stomatitis. (371327)
1979
46
Denture stomatitis and methods influencing its cure. (264550)
1977
47
Aphthous stomatitis as a featuring syndrome of emotional stress in dental treatment. (1076577)
1976
48
DISEASES OF THE MOUTH; DIFFERENTIAL DIAGNOSIS. II. GINGIVITIS, STOMATITIS, GINGIVOSTOMATITIS AND CHEILITIS. (14133077)
1964
49
Ulcerative stomatitis associated with symptoms of peptic ulcer. (13160476)
1954
50
Fever of undetermined etiology associated with bronchopneumonia, conjuctivitis, stomatitis, and adenopathy; Stevens-Johnson syndrome. (18864525)
1948

Genetic Variations for Stomatitis

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Expression for genes affiliated with Stomatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stomatitis

Search GEO for disease gene expression data for Stomatitis.

Pathways for genes affiliated with Stomatitis

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 53Reactome
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Pathways related to Stomatitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TNF, IRF3, IRF7, TBK1, IL12A, MX1
2
Hide members
10.7TNF, IRF3, IRF7, TBK1, IL12A
3
Hide members
10.7IL12A, TBK1, IRF7, IRF3, TNF
410.6TBK1, IRF7, IRF3, TNF
5
Hide members
10.6TBK1, IRF7, IRF3, TNF
610.6TBK1, IRF7, IRF3, TNF
7
Hide members
10.6MX2, MX1, IRF7, IRF3
8
Immune response IFN alpha/beta signaling pathway
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10.6MX2, MX1, IRF7, IRF3
9
Hide members
10.6IRF7, IRF3, TNF
10
Hide members
10.6TNF, IRF3, IRF7
1110.6TNF, IRF3, IL12A
12
Hide members
10.6TBK1, IRF3, TNF
13
Hide members
10.6IRF3, IRF7, TBK1
14
Hide members
10.6TBK1, IRF7, IRF3
15
Hide members
10.6TBK1, IRF7, IRF3
16
Hide members
10.6IRF3, IRF7, TBK1
17
Hide members
10.5TBK1, IRF3
1810.5IRF3, TBK1

Compounds for genes affiliated with Stomatitis

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44Novoseek, 11DrugBank, 28IUPHAR
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Compounds related to Stomatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4411.0MVK, TNF, IRF7, TBK1, CD69, CXCR3
2rantes4410.9TNF, IRF3, IRF7, TBK1, CXCR3, MX1
3poly(i-c)4410.9MX1, CD69, TBK1, IRF7, IRF3, TNF
4ifn-alpha4410.8IRF3, IRF7, CXCR3, MX1
5lipid4410.7MVK, TNF, IRF3, CD69, MX1, CFI
6polyinosinic-polycytidylic acid4410.7TNF, IRF3, IRF7
72,5-oligoadenylate4410.7TNF, IRF7, MX1
8ly2940024410.6CXCR3, CD69, IRF3, TNF
9anakinra44 1111.5TNF, MVK
10isopentenyl diphosphate44 2811.3MVK, CD69

GO Terms for genes affiliated with Stomatitis

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16Gene Ontology
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Biological processes related to Stomatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00961511.0MX1, IL12A, TBK1, IRF7, TNF
2type I interferon-mediated signaling pathwayGO:06033710.9MX2, MX1, IRF7, IRF3
3positive regulation of interferon-alpha productionGO:03272710.9IRF3, IRF7, TBK1
4positive regulation of interferon-beta productionGO:03272810.9IRF3, IRF7, TBK1
5defense response to Gram-positive bacteriumGO:05083010.9IL12A, TBK1, TNF
6cytokine-mediated signaling pathwayGO:01922110.8IRF3, IRF7, MX1, MX2
7MDA-5 signaling pathwayGO:03953010.8IRF7, IRF3
8positive regulation of type I interferon productionGO:03248110.8TBK1, IRF7, IRF3
9type I interferon biosynthetic processGO:04535110.8IRF3, IRF7
10TRIF-dependent toll-like receptor signaling pathwayGO:03566610.7TBK1, IRF7, IRF3
11positive regulation of type I interferon-mediated signaling pathwayGO:06034010.7IRF7, IRF3
12MyD88-independent toll-like receptor signaling pathwayGO:00275610.7IRF3, IRF7, TBK1
13toll-like receptor 3 signaling pathwayGO:03413810.7TBK1, IRF7, IRF3
14toll-like receptor 4 signaling pathwayGO:03414210.6IRF3, IRF7, TBK1
15toll-like receptor signaling pathwayGO:00222410.6TBK1, IRF7, IRF3
16innate immune responseGO:04508710.6CFI, MX1, TBK1, IRF7, IRF3
17apoptotic processGO:00691510.4TNF, IRF3, CXCR3, MX1, TP63

Molecular functions related to Stomatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.7TP63, TBK1, IRF3, TNF, MVK

Products for genes affiliated with Stomatitis

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Sources for Stomatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet