MCID: STM007
MIFTS: 50

Stomatitis malady

Oral diseases category

Summaries for Stomatitis

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Stomatitis is inflammation of the mouth and lips. It refers to any inflammatory process affecting the... more...

MalaCards: Stomatitis is related to behcet's disease and melanoma. An important gene associated with Stomatitis is TP63 (tumor protein p63), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Malaria. The drugs sucralfate and carbamide peroxide and the compounds imiquimod and mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and colon, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Stomatitis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

stomatitis 9 11 46 63


External Ids:

Disease Ontology9 DOID:9637
MeSH36 D013280
NCIt41 C26887

Related Diseases for Stomatitis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Stomatitis:



Diseases related to stomatitis

Symptoms for Stomatitis

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Drugs & Therapeutics for Stomatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Stomatitis

Drug clinical trials:

Search ClinicalTrials for Stomatitis

Search NIH Clinical Center for Stomatitis

Search CenterWatch for Stomatitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Stomatitis

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Anatomical Context for Stomatitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Stomatitis:

34
T cells, Testes, Colon, Brain, Tongue, Skin, Endothelial, Prostate, Bone, Breast, Heart, Lung, Tonsil, Monocytes, B cells, Bone marrow

Animal Models for Stomatitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Stomatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2IL12A, CCR1, MEFV, IRF7, TP63, TNF
2MP:00053877.6IL12A, TNF, ISG15, TP63, IRF7, MEFV

Publications for Stomatitis

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Sources:
53PubMed
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Articles related to Stomatitis:

(show top 50)    (show all 1142)
idTitleAuthorsYear
1
Experimental simulation of radio- and chemoradio stomatitis in rats. (23658931)
2013
2
Assessment of immediate pain relief with laser treatment in recurrent aphthous stomatitis. (23622766)
2013
3
Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study. (24268387)
2013
4
N-terminal phosphorylation of phosphoprotein of vesicular stomatitis virus is required for preventing nucleoprotein from binding to cellular RNAs and for functional template formation. (23283948)
2013
5
Bovine papular stomatitis affecting dairy cows and milkers in midwestern Brazil. (22362531)
2012
6
Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription. (23028327)
2012
7
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
8
Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). (22972085)
2012
9
Elucidating role of salivary proteins in denture stomatitis using a proteomic approach. (23041753)
2012
10
A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion. (21680501)
2011
11
Domestic cattle as a non-conventional amplifying host of vesicular stomatitis New Jersey virus. (21133963)
2011
12
Lesion development and replication kinetics during early infection in cattle inoculated with Vesicular stomatitis New Jersey virus via scarification and black fly (Simulium vittatum) bite. (20858740)
2011
13
Distinct patterns of stomatitis with concurrent cetuximab and radiotherapy for head and neck squamous cell carcinoma. (21852185)
2011
14
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
15
Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. (20173724)
2010
16
Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. (19957332)
2010
17
Ageing exacerbates damage of systemic and salivary neutrophils from patients presenting Candida-related denture stomatitis. (19327169)
2009
18
In vivo biodistribution of a highly attenuated recombinant vesicular stomatitis virus expressing HIV-1 Gag following intramuscular, intranasal, or intravenous inoculation. (19428903)
2009
19
Endothelial nitric oxide synthase gene polymorphisms are not associated with recurrent aphthous stomatitis. (19410237)
2009
20
Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro. (16507098)
2006
21
Effect of low-level laser therapy on Candida albicans growth in patients with denture stomatitis. (15954824)
2005
22
Characterization of the chicken PKR: polymorphism of the gene and antiviral activity against vesicular stomatitis virus. (15070037)
2004
23
Results of double-blind placebo-controlled challenge with nickel salts in patients affected by recurrent aphthous stomatitis. (12915773)
2003
24
IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS). (12140751)
2002
25
Close association of HLA-B52 and HLA-B44 antigens in Israeli Arab adolescents with recurrent aphthous stomatitis. (11177036)
2001
26
Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. (11106761)
2000
27
Oral and maxillofacial pathology case of the month. Recurrent aphthous stomatitis--herpetiform type. (11857822)
2000
28
Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)
1999
29
Chronic ulcerative stomatitis. (9292078)
1997
30
Existence of Candida albicans and microorganisms in denture stomatitis patients. (9372471)
1997
31
Decreased levels of salivary prostaglandin E2 and epidermal growth factor in recurrent aphthous stomatitis. (8850647)
1995
32
Denture stomatitis and ABO blood types. (1800738)
1991
33
Aphthous stomatitis and its management. (1807480)
1991
34
Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (2161946)
1990
35
Characterization of a macrophage-tropic HIV strain that does not alter macrophage cytokine production yet protects macrophages from superinfection by vesicular stomatitis virus. (2171598)
1990
36
Immunological and histological studies on denture stomatitis in children: a pilot study. (2478985)
1988
37
Prevalence and persistence of different strains of Candida albicans in treatment of denture stomatitis. (2985776)
1985
38
Recurrent aphthous stomatitis. (4025106)
1985
39
Recurrent aphthous stomatitis: review of the literature. (6214531)
1982
40
Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)
1981
41
Effect of nystatin in the treatment of denture stomatitis. (6936771)
1980
42
Yeast colonization in the oral cavity and feces in patients with denture stomatitis. (371327)
1979
43
Double-blind study of levamisole in aphthous stomatitis. (105099)
1978
44
Evaluation of the therapeutic effect of levamisole in treatment of recurrent aphthous stomatitis. (105100)
1978
45
Aphthous stomatitis as a featuring syndrome of emotional stress in dental treatment. (1076577)
1976
46
Incidence of immediate and delayed hypersensitivity to Candida albicans in denture stomatitis. (4933599)
1971
47
Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic, and hypersensitivity aspects. (5952294)
1966
48
Antihistaminic agents in the treatment of recurrent aphthous stomatitis. (13037294)
1953
49
Glossitis and stomatitis due to penicillin lozenges and troches. (21016496)
1946
50
Ulcerative Stomatitis in Children. (19975517)
1911

Variations for Stomatitis

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Expression for genes affiliated with Stomatitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stomatitis

Search GEO for disease gene expression data for Stomatitis.

Pathways for genes affiliated with Stomatitis

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Sources:
51PathCards, 55R&D Systems, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters
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Pathways related to Stomatitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8IL12A, TNF
29.8TNF, IL12A
39.8TNF, IL12A
49.8TNF, IL12A
59.8TNF, IL12A
69.8TNF, IL12A
7
Show member pathways
IL27-mediated signaling events39
9.8TNF, IL12A
8
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.5TNF, TP63, IRF7
9
Show member pathways
9.4IL12A, TNF, IRF7
10
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.4TNF, IL12A, IRF7
11
Show member pathways
9.3ISG15, IRF7, MX1
12
Show member pathways
9.3MX1, ISG15, IRF7
13
Show member pathways
9.1IL12A, TNF, CCR1, FGF20
14
Show member pathways
9.1TNF, CCR1, IL12A, FGF20
15
Show member pathways
9.1TNF, CCR1, IL12A, FGF20
16
Show member pathways
9.1IL12A, ISG15, TNF, IRF7
17
Show member pathways
9.0IL12A, TNF, MX1, IRF7

Compounds for genes affiliated with Stomatitis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Stomatitis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1imiquimod46 62 30 1213.0MX1, TNF
2mycophenolate mofetil46 52 1211.9IL12A, TNF
3polyinosinic-polycytidylic acid469.9TNF, IRF7
4neopterin469.8MX1, TNF
5ccl346 3010.7CCR1, TNF
6poly(i-c)469.6TNF, IRF7, MX1
7ifn-alpha469.3MX1, IRF7
82,5-oligoadenylate469.3MX1, IRF7, ISG15, TNF
9cycloheximide469.3TNF, ISG15, CCR1, MX1
10retinoic acid46 2510.2TNF, ISG15, TP63, CCR1
11rantes469.2MX1, CCR1, IRF7, TNF
12leucine468.6ISG15, ELOF1, MEFV, CCR1, MX1

GO Terms for genes affiliated with Stomatitis

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17Gene Ontology
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Biological processes related to Stomatitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to type I interferonGO:03434010.0MX1, ISG15
2defense response to Gram-positive bacteriumGO:0508309.9IL12A, TNF
3positive regulation of osteoclast differentiationGO:0456729.9CCR1, TNF
4extrinsic apoptotic signaling pathwayGO:0971919.8IL12A, TNF
5negative regulation of gene expressionGO:0106299.8TNF, CCR1
6negative regulation of viral genome replicationGO:0450719.8ISG15, TNF, MX1
7positive regulation of interferon-gamma productionGO:0327299.7TNF, IL12A
8positive regulation of ERK1 and ERK2 cascadeGO:0703749.6FGF20, CCR1, TNF
9type I interferon signaling pathwayGO:0603379.5MX1, IRF7, ISG15
10response to virusGO:0096159.3MX1, IL12A, IRF7, TNF
11cytokine-mediated signaling pathwayGO:0192219.2MX1, ISG15, IRF7, CCR1
12inflammatory responseGO:0069549.0TNF, MEFV, CCR1
13innate immune responseGO:0450878.7IRF7, MX1, FGF20, ISG15, MEFV

Products for genes affiliated with Stomatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Stomatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet