MCID: STM007
MIFTS: 51

Stomatitis malady

Summaries for Stomatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Stomatitis is inflammation of the mouth. The term refers to any inflammatory process affecting the... more...

MalaCards: Stomatitis is related to denture stomatitis and ulcerative stomatitis. An important gene associated with Stomatitis is TP63 (tumor protein p63), and among its related pathways are Influenza A and Toll-like receptor signaling pathway. The drugs sucralfate and carbamide peroxide and the compounds serine and rantes have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and colon, and related mouse phenotype immune system.

Aliases & Classifications for Stomatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

stomatitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:9637
MeSH34 D013280
NCIt39 C26887

Related Diseases for Stomatitis

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17GeneCards, 18GeneDecks
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Diseases related to Stomatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1denture stomatitis31.5CST1, PPP6R1, STATH, ALLC
2ulcerative stomatitis31.1TP63
3influenza30.4IRF3, CD69, CXCR3, MX1, MX2, ERVW-1
4encephalitis30.3MX1, ERVW-1
5herpes simplex30.3IRF3, IRF7, MX1, ERVW-1
6lichen planus30.3CXCR3, MX1
7hepatitis30.2MX1
8measles30.1MX1
9melanoma30.1TNF, IRF3, RNPEP, CXCR3, MX1, CFI
10hepatitis b30.0MX1
11newcastle disease30.0IRF3
12dermatitis30.0CXCR3
13hepatitis c29.9TNF, IRF7, CD69, CXCR3, MX1
14sarcoma29.9TP63, ERVW-1
15lupus erythematosus29.9MX1
16rabies29.9MX1
17rheumatoid arthritis29.7TNF, IRF3, CD69, CXCR3, CFI, ERVW-1
18arthritis29.7MVK, TNF, CD69, CXCR3, MX1
19psoriasis29.7TNF, CD69, CXCR3, MX1
20multiple sclerosis29.7TNF, CD69, CXCR3, MX1, ERVW-1
21ovarian cancer29.7CFI, CD69
22periodontal disease29.7TNF
23pneumonia29.7TNF
24diarrhea29.7ALLC
25familial mediterranean fever29.7TNF, MVK
26aphthous stomatitis11.2
27pharyngitis10.6
28cervicitis10.5
29cervical adenitis10.5
30glossitis10.3
31noma10.2
32gingivitis10.2
33periodic fever, aphthous stomatitis, pharyngitis and adenitis10.2
34adenocarcinoma10.2
35cheilitis10.2
36celiac disease10.2
37behcet's disease10.2
38vaccinia10.1
39pemphigus10.1
40neuronitis10.1
41adult syndrome10.1
42central nervous system disease10.1
43nervous system disease10.1
44pancreatitis10.1
45periodontitis10.1
46avian influenza10.0
47lymphocytic choriomeningitis10.0
48ariboflavinosis10.0
49oral candidiasis10.0
50hepatitis a10.0

Graphical network of the top 20 diseases related to Stomatitis:



Diseases related to stomatitis

Clinical Features for Stomatitis

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Drugs & Therapeutics for Stomatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stomatitis

Drug clinical trials:

Search ClinicalTrials for Stomatitis

Search NIH Clinical Center for Stomatitis

Search CenterWatch for Stomatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Stomatitis

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Anatomical Context for Stomatitis

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32MalaCards
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MalaCards organs/tissues related to Stomatitis:

32
T cells, Testes, Colon, Brain, Skin, Tongue, Bone, Prostate, Endothelial, Breast, Heart, Monocytes, B cells, Bone marrow, Lung, Tonsil

Animal Models for Stomatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Stomatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8TP63, MX2, IL12A, CXCR3, CD69, TBK1

Publications for Stomatitis

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Sources:
50PubMed
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Articles related to Stomatitis:

(show top 50)    (show all 1160)
idTitleAuthorsYear
1
Oxidative stress and recurrent aphthous stomatitis. (24407552)
2014
2
Newly identified phosphorylation site in the vesicular stomatitis virus p protein is required for viral RNA synthesis. (24257610)
2014
3
The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer. (23232984)
2013
4
Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (23983059)
2013
5
Periodic fever with aphthous stomatitis, pharyngitis, and adenitis responsive to oral corticosteroids and dapsone. (23785712)
2013
6
Does the presence of anterior mandibular teeth increase the incidence of denture stomatitis? (22984815)
2013
7
Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors. (23364315)
2013
8
Elucidating role of salivary proteins in denture stomatitis using a proteomic approach. (23041753)
2012
9
Treatment with targeted vesicular stomatitis virus generates therapeutic multifunctional anti-tumor memory CD4 T cells. (22240921)
2012
10
Full-length genome analysis of vesicular stomatitis New Jersey virus strains representing the phylogenetic and geographic diversity of the virus. (22825698)
2012
11
Microwave denture disinfection versus nystatin in treating patients with well-controlled type 2 diabetes and denture stomatitis: a randomized clinical trial. (22545252)
2012
12
Characterization of the temporal and spatial distribution and reproductive ratio of vesicular stomatitis outbreaks in Mexico in 2008. (21281198)
2011
13
Association between recurrent aphthous stomatitis and inheritance of a single-nucleotide polymorphism of the NOS2 gene encoding inducible nitric oxide synthase. (21481004)
2011
14
The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient I+-helices. (21207454)
2011
15
HIV-protease inhibitors block the replication of both vesicular stomatitis and influenza viruses at an early post-entry replication step. (21620431)
2011
16
The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus. (21795329)
2011
17
Acute necrotic stomatitis (noma) associated with methicillin-resistant Staphylococcus aureus infection in a newly acquired rhesus macaque (Macaca mulatta). (21332756)
2011
18
In vivo efficacy of alkaline peroxide tablets and mouthwashes on Candida albicans in patients with denture stomatitis. (20857010)
2010
19
Susceptibility of breast cancer cells to an oncolytic matrix (M) protein mutant of vesicular stomatitis virus. (20725101)
2010
20
Relationship between periodontal parameters and BehAset's disease and evaluation of different treatments for oral recurrent aphthous stomatitis. (19076988)
2009
21
Enhanced oncolytic potency of vesicular stomatitis virus through vector-mediated inhibition of NK and NKT cells. (18846115)
2009
22
Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitis. (19534771)
2009
23
Allergic contact stomatitis presenting as geographical tongue with pruritus. (19207382)
2009
24
Recurrent aphthous stomatitis may be initiated by traumatic epithelial implantation and sustained by localized pathergic status. (17768013)
2008
25
Dysfunction of CD4+CD25high T regulatory cells in patients with recurrent aphthous stomatitis. (18318707)
2008
26
Little clinical benefit of early systemic aciclovir for treatment of primary herpetic stomatitis. (19151686)
2008
27
Denture stomatitis. (17366680)
2007
28
Autoimmunity to deltaNp63alpha in chronic ulcerative stomatitis. (17720849)
2007
29
Characterization of the chicken PKR: polymorphism of the gene and antiviral activity against vesicular stomatitis virus. (15070037)
2004
30
An exploration of point, annual, and lifetime prevalence in characterizing recurrent aphthous stomatitis in USA children and youths. (15357677)
2004
31
Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model. (15200120)
2004
32
Chronic ulcerative stomatitis: a case report. (10695945)
2000
33
Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)
1999
34
Miconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in Chinese patients. (9552817)
1997
35
Immunopathogenesis of oral lichen planus and recurrent aphthous stomatitis. (9421220)
1997
36
Recurrent aphthous stomatitis. An update. (8665304)
1996
37
Ten cases of chronic ulcerative stomatitis with stratified epithelium-specific antinuclear antibody. (1869653)
1991
38
Clinical evaluation of benzydamine, chlorhexidine, and placebo mouthwashes in the management of recurrent aphthous stomatitis. (3469601)
1987
39
A case report of the successful treatment of recurrent aphthous stomatitis with some preparations of orally administered transfer factor. (6423292)
1984
40
Effects of suspected foodstuff challenging agents in the etiology of recurrent aphthous stomatitis. (6956825)
1982
41
Serum beta 2 microglobulin in recurrent aphthous stomatitis and BehAset's syndrome. (6178540)
1982
42
Immunofluorescence microscopic studies of recurrent aphthous stomatitis. (7032425)
1981
43
Randomized, double-blind study of levamisole in recurrent aphthous stomatitis. (105101)
1978
44
Levamisole in the treatment of recurrent aphthous stomatitis. (342850)
1978
45
Denture stomatitis. Effects of chlorhexidine and amphotericin B on the mycotic flora. (773085)
1975
46
Treatment of aphthous stomatitis by suppression of intralesional streptococci. (4814943)
1974
47
Contact stomatitis, glossitis, and cheilitis. (4417554)
1974
48
The management of recurrent aphthous stomatitis. (14447178)
1959
49
Aphthous stomatitis; the failure of local hydrocortisone therapy to affect healing time. (14364302)
1955
50
Severe unilateral aphthous stomatitis during early stages of multiple sclerosis; case report. (14811377)
1951

Genetic Variations for Stomatitis

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Expression for genes affiliated with Stomatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stomatitis

Search GEO for disease gene expression data for Stomatitis.

Pathways for genes affiliated with Stomatitis

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 4Cell Signaling Technology, 53Reactome
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Pathways related to Stomatitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7TNF, IRF3, IRF7, TBK1, IL12A, MX1
2
Hide members
10.7TNF, IRF3, IRF7, TBK1, IL12A
3
Hide members
10.7IL12A, TBK1, IRF7, IRF3, TNF
410.6TBK1, IRF7, IRF3, TNF
5
Hide members
10.6TBK1, IRF7, IRF3, TNF
610.6TBK1, IRF7, IRF3, TNF
7
Hide members
10.6MX2, MX1, IRF7, IRF3
8
Immune response IFN alpha/beta signaling pathway
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10.6MX2, MX1, IRF7, IRF3
9
Hide members
10.6IRF7, IRF3, TNF
10
Hide members
10.6TNF, IRF3, IRF7
1110.6TNF, IRF3, IL12A
12
Hide members
10.6TBK1, IRF3, TNF
13
Hide members
10.6IRF3, IRF7, TBK1
14
Hide members
10.6TBK1, IRF7, IRF3
15
Hide members
10.6TBK1, IRF7, IRF3
16
Hide members
10.6IRF3, IRF7, TBK1
17
Hide members
10.5TBK1, IRF3
1810.5IRF3, TBK1

Compounds for genes affiliated with Stomatitis

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44Novoseek, 11DrugBank, 28IUPHAR
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Compounds related to Stomatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4411.0MVK, TNF, IRF7, TBK1, CD69, CXCR3
2rantes4410.9TNF, IRF3, IRF7, TBK1, CXCR3, MX1
3poly(i-c)4410.9MX1, CD69, TBK1, IRF7, IRF3, TNF
4ifn-alpha4410.8IRF3, IRF7, CXCR3, MX1
5lipid4410.7MVK, TNF, IRF3, CD69, MX1, CFI
6polyinosinic-polycytidylic acid4410.7TNF, IRF3, IRF7
72,5-oligoadenylate4410.7TNF, IRF7, MX1
8ly2940024410.6CXCR3, CD69, IRF3, TNF
9anakinra44 1111.5TNF, MVK
10isopentenyl diphosphate44 2811.3MVK, CD69

GO Terms for genes affiliated with Stomatitis

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16Gene Ontology
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Biological processes related to Stomatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00961511.0MX1, IL12A, TBK1, IRF7, TNF
2type I interferon-mediated signaling pathwayGO:06033710.9MX2, MX1, IRF7, IRF3
3positive regulation of interferon-alpha productionGO:03272710.9IRF3, IRF7, TBK1
4positive regulation of interferon-beta productionGO:03272810.9IRF3, IRF7, TBK1
5defense response to Gram-positive bacteriumGO:05083010.9IL12A, TBK1, TNF
6cytokine-mediated signaling pathwayGO:01922110.8IRF3, IRF7, MX1, MX2
7MDA-5 signaling pathwayGO:03953010.8IRF7, IRF3
8positive regulation of type I interferon productionGO:03248110.8TBK1, IRF7, IRF3
9type I interferon biosynthetic processGO:04535110.8IRF3, IRF7
10TRIF-dependent toll-like receptor signaling pathwayGO:03566610.7TBK1, IRF7, IRF3
11positive regulation of type I interferon-mediated signaling pathwayGO:06034010.7IRF7, IRF3
12MyD88-independent toll-like receptor signaling pathwayGO:00275610.7IRF3, IRF7, TBK1
13toll-like receptor 3 signaling pathwayGO:03413810.7TBK1, IRF7, IRF3
14toll-like receptor 4 signaling pathwayGO:03414210.6IRF3, IRF7, TBK1
15toll-like receptor signaling pathwayGO:00222410.6TBK1, IRF7, IRF3
16innate immune responseGO:04508710.6CFI, MX1, TBK1, IRF7, IRF3
17apoptotic processGO:00691510.4TNF, IRF3, CXCR3, MX1, TP63

Molecular functions related to Stomatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.7TP63, TBK1, IRF3, TNF, MVK

Products for genes affiliated with Stomatitis

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  • Antibodies
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Sources for Stomatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet