MCID: STR020
MIFTS: 52

Strabismus malady

Genetic diseases, Eye diseases, Neuronal diseases, Rare diseases categories
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Summaries for Strabismus

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Wikipedia:65 Strabismus (/str??b?zm?s/, from Greek strabism more...

MalaCards based summary: Strabismus is related to spina bifida and hyperopia. An important gene associated with Strabismus is VANGL2 (VANGL planar cell polarity protein 2), and among its related pathways is Wnt Signaling Pathway. The drugs botulinum toxin type a and botulinum toxin type b have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Strabismus

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Sources:
8Disease Ontology, 20GeneTests, 22GTR, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
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Related Diseases for Strabismus

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Diseases in the Strabismus family:

Strabismus 1 Essential Strabismus

Diseases related to Strabismus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 454)
idRelated DiseaseScoreTop Affiliating Genes
1spina bifida30.3VANGL1
2hyperopia30.1VANGL2, VANGL1
3amblyopia10.6
4exotropia10.5
5refractive error10.5
6esotropia10.4
7anisometropia10.4
8thyroiditis10.3
9retinitis10.3
10paralytic squint10.3
11scleritis10.3
12eye disease10.2
13myopia10.2
14cellulitis10.2
15hemifacial hyperplasia strabismus10.2
16orbital cellulitis10.2
17mechanical strabismus10.2
18ophthalmoplegia10.2
19ptosis strabismus ectopic pupils10.2
20blepharospasm10.1
21retinal detachment10.1
22plagiocephaly10.1
23cataract10.1
24craniosynostosis10.1
25crouzon syndrome10.1
26down syndrome10.1
27accommodative esotropia10.1
28aniseikonia10.1
29cerebritis10.1
30synostosis10.1
31delayed speech - facial asymmetry - strabismus - ear lobe creases10.1
32cerebral palsy10.0
33myasthenia gravis10.0
34duane retraction syndrome10.0
35neuronitis10.0
36incontinentia pigmenti achromians10.0
37chronic progressive external ophthalmoplegia10.0
38neuropathy10.0
39retinoblastoma10.0
40congenital fibrosis of the extraocular muscles10.0
41congenital stromal corneal dystrophy10.0
42x-linked congenital stationary night blindness10.0
43duane syndrome type 210.0
44familial congenital fourth cranial nerve palsy10.0
45krauss herman holmes syndrome10.0
46ptosis strabismus diastasis10.0
47schindler disease, type 110.0
48strabismus 110.0
49fibrosis of extraocular muscles, congenital, 110.0
50neural tube defects10.0VANGL1, VANGL2

Graphical network of the top 20 diseases related to Strabismus:



Diseases related to strabismus

Symptoms for Strabismus

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Drugs & Therapeutics for Strabismus

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Drug clinical trials:

Search ClinicalTrials for Strabismus

Search NIH Clinical Center for Strabismus

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Strabismus

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Genetic tests related to Strabismus:

id Genetic test Affiliating Genes
1 Strabismus20
2 Susceptibility to Strabismus22

Anatomical Context for Strabismus

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MalaCards organs/tissues related to Strabismus:

32
Eye, Thyroid, Testes, Cortex, Brain, Bone, Skin

Animal Models for Strabismus or affiliated genes

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Publications for Strabismus

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Articles related to Strabismus:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Effects of Strabismic Amblyopia and Strabismus only on Visuomotor Behaviour: Part III. Temporal Eye-Hand Coordination during Reaching. (25389201)
2014
2
Horizontal and vertical optokinetic eye movements in macaque monkeys with infantile strabismus: directional bias and crosstalk. (24204052)
2014
3
Strabismus resulting from an anomalous extraocular muscle in Gorlin syndrome. (25266843)
2014
4
Origins of strabismus and loss of binocular vision. (25309358)
2014
5
Fibrin glue for closure of conjunctival incision in strabismus surgery: a report by the american academy of ophthalmology. (23820078)
2013
6
Strabismus disrupts binocular synaptic integration in primary visual cortex. (24155315)
2013
7
Infectious Pseudomonas scleritis after strabismus surgery. (23871294)
2013
8
The effect of previous orbital decompression on results of strabismus surgery in patients with Graves' ophthalmopathy. (23528374)
2013
9
The long-term psychosocial impact of corrective surgery for adults with strabismus. (23410730)
2013
10
Strabismus among aged Medicare beneficiaries: impact of health status and region. (23928005)
2013
11
Analysis of visual outcomes and complications following levator resection for unilateral congenital blepharoptosis without strabismus. (23989313)
2013
12
Short-term response of mitomycin C on the human rectus muscle following strabismus surgery: histological, ultrastructural, and biomechanical evaluation. (23380007)
2013
13
Accurate gaze direction measurements with free head movement for strabismus angle estimation. (23399951)
2013
14
Acquired paralytic strabismus in Southern Taiwan. (23608076)
2013
15
Management of strabismus with hemianopic visual field defects. (22588288)
2013
16
Loop suture technique for optional adjustment in strabismus surgery. (24014986)
2013
17
Successful extraocular muscle re-resection for a strabismus surgery complication: a "snapped" [severed, inadvertently] and retrieved inferior rectus muscle: a case report. (22404092)
2012
18
Intraorbital epidermoid cyst: a 5-year-old with exophthalmos and strabismus. (22446470)
2012
19
Prisms are effective in resolving diplopia from incomitant, large, and combined strabismus. (22467592)
2012
20
Ocular alignment and results of strabismus surgery in neurologically impaired children. (22553767)
2012
21
Design and efficacy of surgery for horizontal idiopathic nystagmus with abnormal head posture and strabismus. (22038360)
2011
22
Augmented vertical rectus [corrected] transposition for the treatment of strabismus in MAPbius syndrome. (22153406)
2011
23
Social phobia and other psychiatric problems in children with strabismus. (21784213)
2011
24
Periosteal Flap fixation of the Globe for Surgical Treatment of Severe Restrictive Strabismus: A Report of Eight Cases with Outcomes. (22204549)
2011
25
Insertion slanting strabismus surgical procedures. (22159685)
2011
26
Horizontal strabismus surgery in children and adults. (22035312)
2011
27
Prevalence of and early-life influences on childhood strabismus: findings from the Millennium Cohort Study. (20194258)
2010
28
Pure horizontal strabismus in inferior oblique inclusion syndrome. (21117524)
2010
29
Paralytic strabismus: third, fourth, and sixth nerve palsy. (20638001)
2010
30
The use of titanium T-plate as platform for globe alignment in severe paralytic and restrictive strabismus. (20542486)
2010
31
Epidemiology of surgical strabismus in Saudi Arabia. (20868257)
2010
32
Strabismus following bilateral cataract surgery in childhood. (20700792)
2010
33
Comparison of alternate cover test reliability at near in non-strabismus between experienced and novice examiners. (20444138)
2010
34
In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus. (20338975)
2010
35
Surgical correction of strabismus in Lambert-Eaton myasthenic syndrome: case reports. (19347132)
2009
36
Predictability of strabismus surgery in children with developmental disorders and/or psychomotor retardation. (20804359)
2009
37
Ocular alignment following strabismus surgery. (19321471)
2009
38
Duration of conjunctival redness following adult strabismus surgery. (20006822)
2009
39
Inferior oblique surgery for restrictive strabismus in patients with thyroid orbitopathy. (20126484)
2009
40
Prevalence and pattern of strabismus in Ilorin. (20425742)
2009
41
Effects of amniotic membrane on wound healing and adhesions in experimental strabismus surgery. (19882591)
2009
42
Beware angle kappa: an unusual problem following strabismus surgery. (20001511)
2009
43
Genes on bovine chromosome 18 associated with bilateral convergent strabismus with exophthalmos in German Brown cattle. (18836565)
2008
44
Photorefractive keratectomy followed by strabismus surgery for the treatment of partly accommodative esotropia. (15616503)
2004
45
The aniseikonia answer is "The Aniseikonia Inspector" CD; strabismus surgery problems; ocular "PT"; monovision followup. (12765539)
2003
46
Major review: the clinical spectrum of pediatric myasthenia gravis: blepharoptosis, ophthalmoplegia and strabismus. A report of 14 cases. (12171588)
2002
47
The outcome of strabismus surgery in childhood exotropia. (8925940)
1996
48
A prospective study of the relationship between strabismus and head posture in patients with frontal plagiocephaly. (8618990)
1996
49
Botulinum isn't just a poison anymore. Botulinum toxin in treatment of strabismus and essential blepharospasm. (3974563)
1985
50
Anisometropia and strabismus. (900611)
1977

Variations for Strabismus

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Expression for genes affiliated with Strabismus

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Expression patterns in normal tissues for genes affiliated with Strabismus

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Pathways for genes affiliated with Strabismus

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Pathways related to Strabismus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Wnt Signaling Pathway NetPath37
9.6VANGL1, VANGL2

Compounds for genes affiliated with Strabismus

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GO Terms for genes affiliated with Strabismus

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Cellular components related to Strabismus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.2VANGL2, GPR143
2lysosomal membraneGO:0057658.7MCOLN1, GPR143
3plasma membraneGO:0058867.5FGFR3, VANGL1, VANGL2, MCOLN1, GPR143

Biological processes related to Strabismus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestive tract morphogenesisGO:0485469.4FGFR3, VANGL2
2somatic stem cell maintenanceGO:0350199.2FGFR3, VANGL2
3phosphatidylinositol-mediated signalingGO:0480159.1FGFR3, GPR143

Products for genes affiliated with Strabismus

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  • Antibodies
  • Proteins
  • Lysates

Sources for Strabismus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet