MCID: STR020
MIFTS: 56

Strabismus malady

Eye diseases category

Summaries for Strabismus

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Strabismus (/strəˈbɪzməs/, from Greek strabismós), also known as heterotropia, is a condition in... more...

MalaCards: Strabismus is related to crouzon syndrome and craniosynostosis. An important gene associated with Strabismus is VANGL2 (VANGL planar cell polarity protein 2), and among its related pathways is Neural Crest Differentiation. The drugs isoflurophate and botulinum toxin type a and the compounds su 5402 and fiin 1 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Aliases & Classifications for Strabismus

About this section
Sources:
8Disease Ontology, 20GeneTests, 22GTR, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
See all sources

Related Diseases for Strabismus

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Strabismus family:

Strabismus 1 Essential Strabismus

Diseases related to Strabismus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome30.0FGFR3, FGFR2
2craniosynostosis30.0FGFR2, FGFR3
3exophthalmos29.8TSHR, FGFR2
4astigmatism29.5FGFR3
5intellectual disability29.5OPHN1, PDLIM1
6jackson-weiss syndrome29.5FGFR2, FGFR3
7acrocephalosyndactylia29.5FGFR3, FGFR2
8saethre-chotzen syndrome29.5FGFR3, FGFR2
9amblyopia10.5
10exotropia10.4
11refractive error10.4
12esotropia10.4
13anisometropia10.4
14mechanical strabismus10.3
15thyroiditis10.3
16retinitis10.3
17paralytic squint10.2
18scleritis10.2
19eye disease10.2
20myopia10.2
21hemifacial hyperplasia strabismus10.1
22orbital cellulitis10.1
23cellulitis10.1
24ophthalmoplegia10.1
25ptosis strabismus ectopic pupils10.1
26blepharospasm10.1
27retinal detachment10.1
28aniseikonia10.0
29accommodative esotropia10.0
30down syndrome10.0
31delayed speech - facial asymmetry - strabismus - ear lobe creases10.0
32beare-stevenson cutis gyrata syndrome10.0FGFR2
33acanthosis nigricans10.0FGFR3, FGFR2
34fgfr-related craniosynostosis syndromes10.0FGFR2, FGFR3
35muenke syndrome10.0FGFR3, FGFR2
36ladd syndrome10.0FGFR2, FGFR3
37mental retardation10.0PDLIM1, OPHN1, FGFR3, TSHR
38hypochondroplasia10.0FGFR2, FGFR3
39developmental disabilities10.0HNF4A, FGFR2, FGFR3
40hyperopia10.0FRMD7, VANGL1, VANGL2, FZD6
41thanatophoric dysplasia10.0FGFR3, FGFR2
42neural tube defects10.0VANGL2, VANGL1
43infectious mononucleosis10.0FGFR3, FGFR2
44oculocutaneous albinism10.0
45hypertropia10.0
46neuronitis10.0
47congenital nystagmus10.0
48cataract10.0
49chronic progressive external ophthalmoplegia10.0
50neuropathy10.0

Graphical network of the top 20 diseases related to Strabismus:



Diseases related to strabismus

Clinical Features for Strabismus

About this section

Drugs & Therapeutics for Strabismus

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Strabismus

Drug clinical trials:

Search ClinicalTrials for Strabismus

Search NIH Clinical Center for Strabismus

Search CenterWatch for Strabismus

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Strabismus

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Strabismus:

id Genetic test Affiliating Genes
1 Strabismus20
2 Susceptibility to Strabismus22

Anatomical Context for Strabismus

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Strabismus:

32
Eye, Thyroid, Testes, Cortex, Brain, Bone, Skin

Animal Models for Strabismus or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Strabismus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.0TSHR, SOBP, FZD6, VANGL2, VANGL1, HOXB1
2MP:000539110.0FZD6, VANGL2, MCOLN1, FGFR2, FGFR3, GPR143
3MP:00028739.9HNF4A, FZD6, PPAP2C, VANGL2, VANGL1, HOXB1
4MP:00053789.8PHOX2A, VANGL2, VANGL1, MCOLN1, HOXB1, FGFR2
5MP:00053889.7PHOX2A, VANGL2, VANGL1, HOXB1, FGFR2, FGFR3
6MP:00053869.6SOBP, OPHN1, PHOX2A, VANGL2, MCOLN1, HOXB1
7MP:00107689.6HNF4A, FZD6, OPHN1, PHOX2A, VANGL2, VANGL1
8MP:00036319.5HNF4A, FZD6, OPHN1, PHOX2A, VANGL2, VANGL1

Publications for Strabismus

About this section
Sources:
50PubMed
See all sources

Articles related to Strabismus:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
Prevalence and anatomic mechanism of highly myopic strabismus among Japanese with severe myopia. (24390603)
2014
2
The long-term psychosocial impact of correction surgery for adults with strabismus. (23740958)
2013
3
Development and application of the Chinese version of the adult strabismus quality of life questionnaire (AS-20): a cross-sectional study. (24164742)
2013
4
Simultaneous surgical correction of dissociated vertical deviation, superior oblique overaction and A-pattern with associated horizontal strabismus: A case series. (23772135)
2013
5
The use of amniotic membrane for the management of fibrosis in complex strabismus surgery. (23477772)
2013
6
Postural control in nonamblyopic children with early-onset strabismus. (23150621)
2013
7
Characterization of bangerter filter effect in mild and moderate amblyopia associated with strabismus. (22989340)
2012
8
The ophthalmology surgical competency assessment rubric for strabismus surgery. (22929445)
2012
9
Comparing outcome criteria performance in adult strabismus surgery. (22541935)
2012
10
Incidence of strabismus and amblyopia in preverbal children previously diagnosed with pseudoesotropia. (22525164)
2012
11
Improved ocular alignment with adjustable sutures in adults undergoing strabismus surgery. (22036633)
2012
12
Diplopia after strabismus surgery. (23002467)
2012
13
Comparison of proseal laryngeal mask and endotracheal tube for airway safety in pediatric strabismus surgery. (22485233)
2012
14
Is presoaking suture material prior to strabismus surgery appropriate? (22801531)
2012
15
Evaluation techniques for paretic vertical strabismus. (22069843)
2011
16
Amniotic membrane transplantation for restrictive strabismus. (21292325)
2011
17
Severe fibrosis of extraocular muscles after the use of lyophilized amniotic membrane in strabismus surgery. (21907131)
2011
18
Effects of solid hyaluronic acid film on postoperative fibrous scar formation after strabismus surgery in animals. (20873696)
2011
19
Repair of strabismus and binocular fusion in children with cerebral palsy: gross motor function classification scale. (21873677)
2011
20
Potential linkage of different phenotypic forms of childhood strabismus to a recessive susceptibility locus (16p13.12-p12.3). (21541264)
2011
21
Optical coherence tomographic features in a case of bilateral macular coloboma with strabismus. (22187311)
2011
22
Strabismus-mediated primary archenteron invagination is uncoupled from Wnt/I^-catenin-dependent endoderm cell fate specification in Nematostella vectensis (Anthozoa, Cnidaria): Implications for the evolution of gastrulation. (21255391)
2011
23
Supraventricular tachycardia in a child undergoing strabismus surgery. (21766744)
2011
24
Quality of life and cost-utility assessment after strabismus surgery in adults. (21523376)
2011
25
Effect of superior oblique weakening on vertical alignment and horizontal and vertical incomitance in patients with A-pattern strabismus. (21397799)
2011
26
Paralytic strabismus: third, fourth, and sixth nerve palsy. (20638001)
2010
27
Epidemiology of surgical strabismus in Saudi Arabia. (20868257)
2010
28
A new transconjunctival muscle reinsertion technique for minimally invasive strabismus surgery. (19873948)
2010
29
A surgical option for antipodean strabismus: four horizontal muscle resection. (21158366)
2010
30
Surgical procedure for correcting globe dislocation in highly myopic strabismus. (19939345)
2010
31
Prevalence of refractive error in Singaporean Chinese children: the strabismus, amblyopia, and refractive error in young Singaporean Children (STARS) study. (19933197)
2010
32
Strabismus surgery on the elderly and the effects on disability. (20451866)
2010
33
Cut and paste: a novel method of re-attaching rectus muscles with cyanoacrylate during recessions in strabismus. (20689194)
2010
34
About the mutually alternating condition of the convergence of the visual axes and of clear vision at different distances, and about the various forms of strabismus. 1826. (20230205)
2010
35
Gains beyond cosmesis: recovery of fusion and stereopsis in adults with longstanding strabismus following successful surgical realignment. (20195053)
2010
36
Ocular alignment following strabismus surgery. (19321471)
2009
37
Prevalence and pattern of strabismus in Ilorin. (20425742)
2009
38
Effects of amniotic membrane on wound healing and adhesions in experimental strabismus surgery. (19882591)
2009
39
Visual outcome in 879 children treated for strabismus: insufficient accommodation and vision deprivation, deficient emmetropisation and anisometropia. (20001509)
2009
40
Cul-de-sac incision for strabismus surgery in older patients. (20001952)
2009
41
Prevalence of amblyopia and strabismus in white and African American children aged 6 through 71 months the Baltimore Pediatric Eye Disease Study. (19762084)
2009
42
Surgical correction of severe strabismus and enophthalmos secondary to zygomatic arch fracture in a dog. (19261168)
2009
43
Pattern recognition of vertical strabismus using an artificial neural network (StrabNet). (20001506)
2009
44
Effect of preoperative stability of alignment on outcome of strabismus surgery for infantile esotropia. (18929309)
2008
45
Inadvertent scleral perforation after strabismus surgery: incidence and association with refractive error. (19020632)
2008
46
The aniseikonia answer is "The Aniseikonia Inspector" CD; strabismus surgery problems; ocular "PT"; monovision followup. (12765539)
2003
47
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. (10928671)
2000
48
Giant orbital cyst after strabismus surgery. (10428593)
1999
49
The outcome of strabismus surgery in childhood exotropia. (7867818)
1994
50
Necrotizing scleritis and transient myopia following strabismus surgery. (8115100)
1993

Genetic Variations for Strabismus

About this section

Expression for genes affiliated with Strabismus

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Strabismus

Search GEO for disease gene expression data for Strabismus.

Pathways for genes affiliated with Strabismus

About this section
Sources:
37NCBI BioSystems Database
See all sources

Pathways related to Strabismus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2FGFR3, FGFR2, HOXB1

Compounds for genes affiliated with Strabismus

About this section
Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank
See all sources

Compounds related to Strabismus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1su 54025910.5FGFR3, FGFR2
2fiin 1 hydrochloride5910.4FGFR3, FGFR2
3pd 1615705910.4FGFR3, FGFR2
4su54024410.3FGFR2, FGFR3
5Ponatinib 1110.3FGFR3, FGFR2
6pd 17307444 5911.2FGFR3, FGFR2
7palifermin44 1111.0FGFR3, FGFR2

GO Terms for genes affiliated with Strabismus

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Strabismus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1membranous septum morphogenesisGO:00314910.5FGFR2, VANGL2
2positive regulation of phospholipase activityGO:01051810.5FGFR3, FGFR2
3negative regulation of mitosisGO:04583910.4FGFR3, FGFR2
4lens fiber cell developmentGO:07030710.4FGFR2, FGFR3
5inner ear morphogenesisGO:04247210.4SOBP, FZD6, FGFR2
6establishment of planar polarityGO:00173610.3VANGL2, FZD6
7phosphatidylinositol-mediated signalingGO:04801510.2GPR143, FGFR3, FGFR2
8digestive tract morphogenesisGO:04854610.2FGFR3, VANGL2
9bone morphogenesisGO:06034910.0FGFR2, FGFR3

Molecular functions related to Strabismus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:01713410.3FGFR3, FGFR2
2fibroblast growth factor-activated receptor activityGO:00500710.0FGFR3, FGFR2

Products for genes affiliated with Strabismus

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Strabismus

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet