MCID: STR020
MIFTS: 53

Strabismus malady

Eye category

Summaries for Strabismus

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Strabismus (/strəˈbɪzməs/, from Greek strabismós), also known as heterotropia (and including the... more...

MalaCards: Strabismus is related to crouzon syndrome and hyperopia. An important gene associated with Strabismus is VANGL2 (VANGL planar cell polarity protein 2), and among its related pathways is Neural Crest Differentiation. The drugs botulinum toxin type a and botulinum toxin type b and the compounds fiin 1 hydrochloride and pd 161570 have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and smooth muscle, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Aliases & Classifications for Strabismus

Sources:
8Disease Ontology, 20GeneTests, 22GTR, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

strabismus 8 20 22 45 61


External Ids:

Disease Ontology8 DOID:540
ICD9CM27 378.7
ICD1025 H50.8, H50.9

Related Diseases for Strabismus

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Strabismus family:

strabismus 1 essential strabismus

Diseases related to Strabismus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 434)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome30.0FGFR3, FGFR2
2hyperopia29.9FZD6, FRMD7, VANGL1, VANGL2
3exophthalmos29.8FGFR2, TSHR
4astigmatism29.6FGFR3
5jackson-weiss syndrome29.6FGFR3, FGFR2
6mental retardation29.6TSHR, FGFR3, PDLIM1, OPHN1
7acrocephalosyndactylia29.6FGFR2, FGFR3
8saethre-chotzen syndrome29.6FGFR3, FGFR2
9amblyopia10.6
10anisometropia10.4
11strabismus 110.3
12n syndrome10.2
13hemifacial hyperplasia strabismus10.2
14orbital cellulitis10.1
15cellulitis10.1
16ptosis strabismus ectopic pupils10.1
17blepharospasm10.1
18plagiocephaly10.1
19aniseikonia10.0
20accommodative esotropia10.0
21delayed speech - facial asymmetry - strabismus - ear lobe creases10.0
22essential strabismus10.0
23beare-stevenson cutis gyrata syndrome10.0FGFR2
24acanthosis nigricans10.0FGFR3, FGFR2
25intellectual disability10.0OPHN1, PDLIM1
26fgfr-related craniosynostosis syndromes10.0FGFR2, FGFR3
27muenke syndrome10.0FGFR2, FGFR3
28ladd syndrome10.0FGFR3, FGFR2
29hypochondroplasia10.0FGFR3, FGFR2
30developmental disabilities10.0HNF4A, FGFR2, FGFR3
31craniosynostosis10.0FGFR2, FGFR3
32thanatophoric dysplasia10.0FGFR3, FGFR2
33neural tube defects10.0VANGL1, VANGL2
34infectious mononucleosis10.0FGFR2, FGFR3
35oculocutaneous albinism10.0
36hypertropia10.0
37congenital nystagmus10.0
38x-linked congenital stationary night blindness10.0
39schindler disease, type 110.0
40krauss herman holmes syndrome10.0
41ptosis strabismus diastasis10.0
42periventricular leukomalacia9.9
43williams-beuren syndrome9.9
44incontinentia pigmenti achromians9.9
45filamentary keratitis9.9
46social phobia9.9
47ischemic neuropathy9.9
48monofixation syndrome9.9
49hypotropia9.9
50cyclotropia9.9

Graphical network of the top 20 diseases related to Strabismus:



Diseases related to strabismus

Clinical Features for Strabismus

Drugs & Therapeutics for Strabismus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Strabismus

Drug clinical trials:

Search ClinicalTrials for Strabismus

Search NIH Clinical Center for Strabismus

Search CenterWatch for Strabismus

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Strabismus

Sources:
20GeneTests, 22GTR
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Genetic tests related to Strabismus:

id Genetic test Affiliating Genes
1 Strabismus20
2 Susceptibility To Strabismus22

Anatomical Context for Strabismus

Sources:
33MalaCards
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MalaCards organs/tissues related to Strabismus:

33
Brain, Cortex, Smooth muscle, Thyroid, Skin, T cells

Animal Models for Strabismus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Strabismus

Sources:
51PubMed
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Articles related to Strabismus:

(show top 50)    (show all 624)
idTitleAuthorsYear
1
Analysis of visual outcomes and complications following levator resection for unilateral congenital blepharoptosis without strabismus. (23989313)
2013
2
Acquired paralytic strabismus in Southern Taiwan. (23608076)
2013
3
Surgical Procedure Joining the Lateral Rectus and Superior Rectus Muscles With or Without Medial Rectus Recession for the Treatment of Strabismus Associated With High Myopia. (24281120)
2013
4
Clinical characteristics of patients that experience different rates of exodrift after strabismus surgery for intermittent exotropia and the effect of the rate ofA exodrift on final ocular alignment. (23415036)
2013
5
Intelligence Quotient (IQ) in Congenital Strabismus. (23943689)
2013
6
Sagging eye syndrome: connective tissue involution as a cause of horizontal and vertical strabismus in older patients. (23471194)
2013
7
The impact of strabismus on quality of life in adults with and without diplopia: a systematic review. (24359806)
2013
8
The long-term psychosocial impact of corrective surgery for adults with strabismus. (23853168)
2013
9
Globe perforation during strabismus surgery in an animal model. (22525190)
2012
10
Strabismus surgery hemostasis. (22385487)
2012
11
Strabismus surgery learning for Ophthalmology residents of university service. (22872202)
2012
12
Factors associated with the direction of ocular deviation in sensory horizontal strabismus and unilateral organic ocular problems. (22670077)
2012
13
Mini-plication to treat small-angle strabismus: A minimally invasive procedure. (22929447)
2012
14
Responses of cells in the midbrain near-response area in monkeys with strabismus. (22562519)
2012
15
Comparison of preoperative and postoperative anterior segment measurements with PentacamAr in strabismus surgery. (22588729)
2012
16
Botulinum toxin for the treatment of strabismus. (22336817)
2012
17
Comitant horizontal strabismus in South African black and mixed race children--a clinic-based study. (22364622)
2012
18
Globe fixation with homologous temporalis fascia transplant for treatment of restrictive esotropia strabismus: an interventional case report and review of the literature. (22204550)
2011
19
Negative social reaction to strabismus in school children ages 8-12 years. (21683635)
2011
20
Excitatory binocular interactions in two cases of alternating strabismus. (21907116)
2011
21
The association of refractive error, strabismus, and amblyopia with congenital ptosis. (22153397)
2011
22
Refractive surgery: a treatment for and a cause of strabismus. (21537187)
2011
23
Strabismus and discrimination in children: are children with strabismus invited to fewer birthday parties? (20720253)
2011
24
A survey of the management of globe perforation during strabismus surgery in the United Kingdom. (21635169)
2011
25
Prevalence of and early-life influences on childhood strabismus: findings from the Millennium Cohort Study. (20194258)
2010
26
The use of titanium T-plate as platform for globe alignment in severe paralytic and restrictive strabismus. (20542486)
2010
27
Should we require evidence about the etiology of A-pattern strabismus? (20227613)
2010
28
Responsiveness of health-related quality-of-life questionnaires in adults undergoing Strabismus surgery. (20832120)
2010
29
Utility analysis of disability caused by amblyopia and/or strabismus in a population-based, historic cohort. (20697731)
2010
30
About the mutually alternating condition of the convergence of the visual axes and of clear vision at different distances, and about the various forms of strabismus. 1826. (20843190)
2010
31
Understanding, detecting, and managing strabismus. (20523857)
2010
32
Detachment of the choroid after strabismus surgery in high myopia. (21469527)
2010
33
Strabismus surgical skills assessment tool: development of a surgical assessment tool for strabismus surgery training. (20541739)
2010
34
Vision-related quality of life and emotional impact in children with strabismus: a prospective study. (19761693)
2009
35
Adult strabismus and social phobia: a case-controlled study. (19541264)
2009
36
Is one eye better than two in strabismus? Or does the misaligned amblyopic eye interfere with binocular vision? A preliminary functional MRI study. (20001950)
2009
37
Strabismus surgery: what's next? (19541262)
2009
38
Gains beyond cosmesis: Recovery of fusion and stereopsis in adults with longstanding strabismus following successful surgical realignment. (19237789)
2009
39
Testability of vision and refraction in preschoolers: the strabismus, amblyopia, and refractive error study in singaporean children. (19426960)
2009
40
Magnetic resonance imaging of the extraocular muscle path before and after strabismus surgery for a large degree of cyclotorsion induced by macular translocation surgery. (19333697)
2009
41
Innervated myotendinous cylinders alterations in human extraocular muscles in patients with strabismus. (19568357)
2009
42
Effect of preoperative stability of alignment on outcome of strabismus surgery for infantile esotropia. (18160320)
2008
43
High AC/A accommodative esotropia strabismus treated with contact lenses: a single case design (N=1) study. (17688417)
2007
44
Blinding orbital cellulitis: a complication of strabismus surgery. (17117105)
2006
45
Suprachoroidal septic effusion leading to panophthalmitis following strabismus surgery. (16121559)
2005
46
Photorefractive keratectomy followed by strabismus surgery for the treatment of partly accommodative esotropia. (15616503)
2004
47
Major review: the clinical spectrum of pediatric myasthenia gravis: blepharoptosis, ophthalmoplegia and strabismus. A report of 14 cases. (12171588)
2002
48
Visual and perceptual characteristics, ocular motility and strabismus in children with periventricular leukomalacia. (12221499)
2002
49
Botulinum toxin for the treatment of blepharospasm and strabismus. (2219878)
1990
50
Etiology and pathogenesis of fixation anomalies in strabismus. IV. Roles of suppression scotoma and of motor factors. (5414004)
1970

Genetic Variations for Strabismus

Expression for genes affiliated with Strabismus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Strabismus

Search GEO for disease gene expression data for Strabismus.

Pathways for genes affiliated with Strabismus

Sources:
38NCBI BioSystems Database
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Pathways related to Strabismus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2FGFR3, FGFR2, HOXB1

Compounds for genes affiliated with Strabismus

Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank
See all sources

Compounds related to Strabismus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fiin 1 hydrochloride6010.5FGFR2, FGFR3
2pd 1615706010.4FGFR2, FGFR3
3su 54026010.4FGFR3, FGFR2
4su54024510.3FGFR3, FGFR2
5Ponatinib 1110.3FGFR3, FGFR2
6pd 17307445 6011.2FGFR3, FGFR2
7palifermin45 1111.0FGFR3, FGFR2

GO Terms for genes affiliated with Strabismus

Sources:
16Gene Ontology
See all sources

Biological processes related to Strabismus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:01051810.5FGFR2, FGFR3
2membranous septum morphogenesisGO:00314910.5FGFR2, VANGL2
3negative regulation of mitosisGO:04583910.4FGFR2, FGFR3
4lens fiber cell developmentGO:07030710.4FGFR3, FGFR2
5inner ear morphogenesisGO:04247210.4SOBP, FZD6, FGFR2
6establishment of planar polarityGO:00173610.3FZD6, VANGL2
7phosphatidylinositol-mediated signalingGO:04801510.2GPR143, FGFR3, FGFR2
8digestive tract morphogenesisGO:04854610.2FGFR3, VANGL2
9bone morphogenesisGO:06034910.0FGFR3, FGFR2

Molecular functions related to Strabismus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:01713410.3FGFR3, FGFR2
2fibroblast growth factor-activated receptor activityGO:00500710.0FGFR3, FGFR2

Products for genes affiliated with Strabismus

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  • Antibodies

Sources for Strabismus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet