MCID: STR020
MIFTS: 56

Strabismus malady

Eye diseases category

Summaries for Strabismus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Strabismus (/strəˈbɪzməs/, from Greek strabismós), also known as heterotropia, is a condition in... more...

MalaCards: Strabismus is related to crouzon syndrome and craniosynostosis. An important gene associated with Strabismus is VANGL2 (VANGL planar cell polarity protein 2), and among its related pathways is Neural Crest Differentiation. The drugs isoflurophate and botulinum toxin type a and the compounds su 5402 and fiin 1 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Aliases & Classifications for Strabismus

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8Disease Ontology, 20GeneTests, 22GTR, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Related Diseases for Strabismus

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17GeneCards, 18GeneDecks
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Diseases in the Strabismus family:

Strabismus 1 Essential Strabismus

Diseases related to Strabismus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome30.0FGFR3, FGFR2
2craniosynostosis30.0FGFR2, FGFR3
3exophthalmos29.8TSHR, FGFR2
4astigmatism29.5FGFR3
5intellectual disability29.5OPHN1, PDLIM1
6jackson-weiss syndrome29.5FGFR2, FGFR3
7acrocephalosyndactylia29.5FGFR3, FGFR2
8saethre-chotzen syndrome29.5FGFR3, FGFR2
9amblyopia10.5
10exotropia10.4
11refractive error10.4
12esotropia10.4
13anisometropia10.4
14mechanical strabismus10.3
15thyroiditis10.3
16retinitis10.3
17paralytic squint10.2
18scleritis10.2
19eye disease10.2
20myopia10.2
21hemifacial hyperplasia strabismus10.1
22orbital cellulitis10.1
23cellulitis10.1
24ophthalmoplegia10.1
25ptosis strabismus ectopic pupils10.1
26blepharospasm10.1
27retinal detachment10.1
28aniseikonia10.0
29accommodative esotropia10.0
30down syndrome10.0
31delayed speech - facial asymmetry - strabismus - ear lobe creases10.0
32beare-stevenson cutis gyrata syndrome10.0FGFR2
33acanthosis nigricans10.0FGFR3, FGFR2
34fgfr-related craniosynostosis syndromes10.0FGFR2, FGFR3
35muenke syndrome10.0FGFR3, FGFR2
36ladd syndrome10.0FGFR2, FGFR3
37mental retardation10.0PDLIM1, OPHN1, FGFR3, TSHR
38hypochondroplasia10.0FGFR2, FGFR3
39developmental disabilities10.0HNF4A, FGFR2, FGFR3
40hyperopia10.0FRMD7, VANGL1, VANGL2, FZD6
41thanatophoric dysplasia10.0FGFR3, FGFR2
42neural tube defects10.0VANGL2, VANGL1
43infectious mononucleosis10.0FGFR3, FGFR2
44oculocutaneous albinism10.0
45hypertropia10.0
46neuronitis10.0
47congenital nystagmus10.0
48cataract10.0
49chronic progressive external ophthalmoplegia10.0
50neuropathy10.0

Graphical network of the top 20 diseases related to Strabismus:



Diseases related to strabismus

Clinical Features for Strabismus

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Drugs & Therapeutics for Strabismus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Strabismus

Drug clinical trials:

Search ClinicalTrials for Strabismus

Search NIH Clinical Center for Strabismus

Search CenterWatch for Strabismus

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Strabismus

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20GeneTests, 22GTR
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Genetic tests related to Strabismus:

id Genetic test Affiliating Genes
1 Strabismus20
2 Susceptibility to Strabismus22

Anatomical Context for Strabismus

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32MalaCards
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MalaCards organs/tissues related to Strabismus:

32
Eye, Thyroid, Testes, Cortex, Brain, Skin, Bone

Animal Models for Strabismus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Strabismus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.0TSHR, SOBP, FZD6, VANGL2, VANGL1, HOXB1
2MP:000539110.0FZD6, VANGL2, MCOLN1, FGFR2, FGFR3, GPR143
3MP:00028739.9HNF4A, FZD6, PPAP2C, VANGL2, VANGL1, HOXB1
4MP:00053789.8PHOX2A, VANGL2, VANGL1, MCOLN1, HOXB1, FGFR2
5MP:00053889.7PHOX2A, VANGL2, VANGL1, HOXB1, FGFR2, FGFR3
6MP:00053869.6SOBP, OPHN1, PHOX2A, VANGL2, MCOLN1, HOXB1
7MP:00107689.6HNF4A, FZD6, OPHN1, PHOX2A, VANGL2, VANGL1
8MP:00036319.5HNF4A, FZD6, OPHN1, PHOX2A, VANGL2, VANGL1

Publications for Strabismus

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50PubMed
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Articles related to Strabismus:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
Horizontal and vertical optokinetic eye movements in macaque monkeys with infantile strabismus: directional bias and crosstalk. (24204052)
2014
2
Factors associated with quality of life and mood in adults with strabismus. (24390164)
2014
3
Fibrin glue for closure of conjunctival incision in strabismus surgery: a report by the american academy of ophthalmology. (23820078)
2013
4
Short-term response of mitomycin C on the human rectus muscle following strabismus surgery: histological, ultrastructural, and biomechanical evaluation. (23380007)
2013
5
Management of strabismus with hemianopic visual field defects. (22588288)
2013
6
Loop suture technique for optional adjustment in strabismus surgery. (24014986)
2013
7
Effect of ketamine and midazolam on oculocardiac reflex in pediatric strabismus surgery. (23814649)
2013
8
Restrictive strabismus: an unusual presentation of an intraorbital foreign body. (23419304)
2013
9
Long-term follow-up of strabismus surgery for patients with ocular myasthenia gravis. (23403387)
2013
10
Efficacy of modified cover testing for detection of incipient true strabismus with pseudostrabismus diagnosis. (24141755)
2013
11
Strabismus surgery outcomes after scleral buckling procedures for retinal reattachment. (24299332)
2013
12
Concurrence of inv(7)(q11.2q32) and del(8)(p23.1) in a girl with congenital microcephaly, hypotonia, developmental delay, strabismus, hypernatremia, hypermagnesemia and deafness. (23072189)
2012
13
Outcomes of strabismus surgery for esotropia in children with Down syndrome compared with matched controls. (22329551)
2012
14
Restrictive strabismus. (22214960)
2012
15
General health-related quality of life in preschool children with strabismus or amblyopia. (20884059)
2011
16
Strabismus: aligning the doctor's vision with the patient's need. (21030414)
2011
17
Nonaneurysmal cranial nerve compression as cause of neuropathic strabismus: evidence from high-resolution magnetic resonance imaging. (21861970)
2011
18
Comment on: cut and paste: a novel method of re-attaching rectus muscles with cyanoacrylate during recessions in strabismus. (22011509)
2011
19
Health-related quality of life measures (HRQoL) in patients with amblyopia and strabismus: a systematic review. (20693563)
2011
20
Functional magnetic resonance imaging of binocular interactions in visual cortex in strabismus. (21117523)
2011
21
Measurement of the limbus-insertion distance in adult strabismus patients with anterior segment optical coherence tomography. (21948556)
2011
22
A 4 year retrospective survey of strabismus surgery in Tongren Eye Centre Beijing. (20444139)
2010
23
Is 6 months of stable angle of strabismus enough to perform surgery in patients with strabismus related to thyroid ophthalmopathy? (20511632)
2010
24
Management of intermittent exotropia strabismus of the divergence excess type. (21138415)
2010
25
The management of strabismus in patients with chronic progressive external ophthalmoplegia. (20521878)
2010
26
A rabbit model of conjunctival injection induction after strabismus surgery enhanced by topical application of irritant chemicals. (20307047)
2010
27
Postoperative nausea and vomiting in paediatric strabismus surgery. (20837729)
2010
28
Severe fibrosis of extraocular muscles after the use of lyophilized amniotic membrane in strabismus surgery. (21168080)
2010
29
Topical anesthesia in strabismus surgery: a review of 101 cases. (19645400)
2009
30
Five cases of paralytic strabismus as a rare feature of lyme disease. (19193112)
2009
31
Mutations in KIF21A and PHOX2A are absent in 16 patients with congenital vertical incomitant strabismus. (19852579)
2009
32
An unusual complication after strabismus surgery. (19652240)
2009
33
Comparison of quality-of-life instruments in adults with strabismus. (19570519)
2009
34
Refractive errors and strabismus in children with tuberous sclerosis: a controlled study. (19928739)
2009
35
Genes on bovine chromosome 18 associated with bilateral convergent strabismus with exophthalmos in German Brown cattle. (18836565)
2008
36
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? (19132949)
2008
37
Does assessing eye alignment along with refractive error or visual acuity increase sensitivity for detection of strabismus in preschool vision screening? (17591881)
2007
38
Anterior necrotizing scleritis after strabismus surgery in a child. (17416330)
2007
39
Identification and developmental expression pattern of van gogh-like 1, a second zebrafish strabismus homologue. (15053985)
2004
40
Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23. (12011999)
2002
41
Consecutive exotropia following strabismus surgery. (12207126)
2002
42
Surgical management of V-pattern strabismus and oblique dysfunction in craniofacial dysostosis. (11124667)
2000
43
The prevalence of strabismus in congenital nystagmus: the influence of anterior visual pathway disease. (10530980)
1997
44
Retinal perforation in strabismus surgery. (9083958)
1997
45
Strabismus and Williams-Beuren syndrome. Presentation of 3 operated cases]. (8766044)
1996
46
Asymmetry of motion VEP in infantile strabismus and in central vestibular nystagmus. (7493538)
1995
47
Overgrowth, congenital hypotonia, nystagmus, strabismus, and mental retardation: variant of dominantly inherited Sotos sequence? (3400723)
1988
48
Amniotic band syndrome and strabismus. (7202045)
1982
49
A simple method for screening of children with strabismus, anisometropia or ametropia by simultaneous photography of the corneal and the fundus reflexes. (452880)
1979
50
AN APPROACH TO MEASURING ANISEIKONIA IN NON-FUSING STRABISMUS--A PRELIMINARY REPORT. (14077196)
1963

Genetic Variations for Strabismus

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Expression for genes affiliated with Strabismus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Strabismus

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Pathways for genes affiliated with Strabismus

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37NCBI BioSystems Database
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Pathways related to Strabismus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2FGFR3, FGFR2, HOXB1

Compounds for genes affiliated with Strabismus

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59Tocris Bioscience, 44Novoseek, 11DrugBank
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Compounds related to Strabismus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1su 54025910.5FGFR3, FGFR2
2fiin 1 hydrochloride5910.4FGFR3, FGFR2
3pd 1615705910.4FGFR3, FGFR2
4su54024410.3FGFR2, FGFR3
5Ponatinib 1110.3FGFR3, FGFR2
6pd 17307444 5911.2FGFR3, FGFR2
7palifermin44 1111.0FGFR3, FGFR2

GO Terms for genes affiliated with Strabismus

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16Gene Ontology
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Biological processes related to Strabismus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1membranous septum morphogenesisGO:00314910.5FGFR2, VANGL2
2positive regulation of phospholipase activityGO:01051810.5FGFR3, FGFR2
3negative regulation of mitosisGO:04583910.4FGFR3, FGFR2
4lens fiber cell developmentGO:07030710.4FGFR2, FGFR3
5inner ear morphogenesisGO:04247210.4SOBP, FZD6, FGFR2
6establishment of planar polarityGO:00173610.3VANGL2, FZD6
7phosphatidylinositol-mediated signalingGO:04801510.2GPR143, FGFR3, FGFR2
8digestive tract morphogenesisGO:04854610.2FGFR3, VANGL2
9bone morphogenesisGO:06034910.0FGFR2, FGFR3

Molecular functions related to Strabismus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:01713410.3FGFR3, FGFR2
2fibroblast growth factor-activated receptor activityGO:00500710.0FGFR3, FGFR2

Products for genes affiliated with Strabismus

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  • Antibodies
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Sources for Strabismus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet