MCID: STR020
MIFTS: 56

Strabismus malady

Eye diseases category

Summaries for Strabismus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Strabismus (/strəˈbɪzməs/, from Greek strabismós), also known as heterotropia, is a condition in... more...

MalaCards: Strabismus is related to crouzon syndrome and craniosynostosis. An important gene associated with Strabismus is VANGL2 (VANGL planar cell polarity protein 2), and among its related pathways is Neural Crest Differentiation. The drugs isoflurophate and botulinum toxin type a and the compounds su 5402 and fiin 1 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Aliases & Classifications for Strabismus

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8Disease Ontology, 20GeneTests, 22GTR, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Related Diseases for Strabismus

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17GeneCards, 18GeneDecks
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Diseases in the Strabismus family:

Strabismus 1 Essential Strabismus

Diseases related to Strabismus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome30.0FGFR3, FGFR2
2craniosynostosis30.0FGFR2, FGFR3
3exophthalmos29.8TSHR, FGFR2
4astigmatism29.5FGFR3
5intellectual disability29.5OPHN1, PDLIM1
6jackson-weiss syndrome29.5FGFR2, FGFR3
7acrocephalosyndactylia29.5FGFR3, FGFR2
8saethre-chotzen syndrome29.5FGFR3, FGFR2
9amblyopia10.5
10exotropia10.4
11refractive error10.4
12esotropia10.4
13anisometropia10.4
14mechanical strabismus10.3
15thyroiditis10.3
16retinitis10.3
17paralytic squint10.2
18scleritis10.2
19eye disease10.2
20myopia10.2
21hemifacial hyperplasia strabismus10.1
22orbital cellulitis10.1
23cellulitis10.1
24ophthalmoplegia10.1
25ptosis strabismus ectopic pupils10.1
26blepharospasm10.1
27retinal detachment10.1
28aniseikonia10.0
29accommodative esotropia10.0
30down syndrome10.0
31delayed speech - facial asymmetry - strabismus - ear lobe creases10.0
32beare-stevenson cutis gyrata syndrome10.0FGFR2
33acanthosis nigricans10.0FGFR3, FGFR2
34fgfr-related craniosynostosis syndromes10.0FGFR2, FGFR3
35muenke syndrome10.0FGFR3, FGFR2
36ladd syndrome10.0FGFR2, FGFR3
37mental retardation10.0PDLIM1, OPHN1, FGFR3, TSHR
38hypochondroplasia10.0FGFR2, FGFR3
39developmental disabilities10.0HNF4A, FGFR2, FGFR3
40hyperopia10.0FRMD7, VANGL1, VANGL2, FZD6
41thanatophoric dysplasia10.0FGFR3, FGFR2
42neural tube defects10.0VANGL2, VANGL1
43infectious mononucleosis10.0FGFR3, FGFR2
44oculocutaneous albinism10.0
45hypertropia10.0
46neuronitis10.0
47congenital nystagmus10.0
48cataract10.0
49chronic progressive external ophthalmoplegia10.0
50neuropathy10.0

Graphical network of the top 20 diseases related to Strabismus:



Diseases related to strabismus

Clinical Features for Strabismus

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Drugs & Therapeutics for Strabismus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Strabismus

Drug clinical trials:

Search ClinicalTrials for Strabismus

Search NIH Clinical Center for Strabismus

Search CenterWatch for Strabismus

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Strabismus

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20GeneTests, 22GTR
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Genetic tests related to Strabismus:

id Genetic test Affiliating Genes
1 Strabismus20
2 Susceptibility to Strabismus22

Anatomical Context for Strabismus

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32MalaCards
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MalaCards organs/tissues related to Strabismus:

32
Eye, Thyroid, Testes, Cortex, Brain, Bone, Skin

Animal Models for Strabismus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Strabismus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.0TSHR, SOBP, FZD6, VANGL2, VANGL1, HOXB1
2MP:000539110.0FZD6, VANGL2, MCOLN1, FGFR2, FGFR3, GPR143
3MP:00028739.9HNF4A, FZD6, PPAP2C, VANGL2, VANGL1, HOXB1
4MP:00053789.8PHOX2A, VANGL2, VANGL1, MCOLN1, HOXB1, FGFR2
5MP:00053889.7PHOX2A, VANGL2, VANGL1, HOXB1, FGFR2, FGFR3
6MP:00053869.6SOBP, OPHN1, PHOX2A, VANGL2, MCOLN1, HOXB1
7MP:00107689.6HNF4A, FZD6, OPHN1, PHOX2A, VANGL2, VANGL1
8MP:00036319.5HNF4A, FZD6, OPHN1, PHOX2A, VANGL2, VANGL1

Publications for Strabismus

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50PubMed
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Articles related to Strabismus:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
The long-term psychosocial impact of corrective surgery for adults with strabismus. (23410730)
2013
2
Accurate gaze direction measurements with free head movement for strabismus angle estimation. (23399951)
2013
3
Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus. (23128899)
2013
4
Visuomotor control following surgical correction of strabismus in adults. (23931469)
2013
5
Pattern Strabismus: Where Does the Brain's Role End and the Muscle's Begin? (23864934)
2013
6
Surgical results after one-muscle recession for correction of horizontal sensory strabismus in children. (23622449)
2013
7
The use of botulinum toxin to treat strabismus following retinal detachment surgery. (23477771)
2013
8
Successful extraocular muscle re-resection for a strabismus surgery complication: a "snapped" [severed, inadvertently] and retrieved inferior rectus muscle: a case report. (22404092)
2012
9
Ocular alignment and results of strabismus surgery in neurologically impaired children. (22553767)
2012
10
Horizontal strabismus worldwide--what are the risk factors? (22568423)
2012
11
Visual Loss due to non-arteritic anterior ischemic optic neuropathy (NAION) immediately following routine strabismus surgery under general anesthesia-a case report. (22906382)
2012
12
A preequatorial Gore-Tex sling to restore rectus muscle pathways in myopic strabismus fixus. (22370671)
2012
13
Prevalence of neurological involvement and malformative/systemic syndromes in A- and V-pattern strabismus. (22978531)
2012
14
Surgery with intraoperative botulinum toxin-A injection for the treatment of large-angle horizontal strabismus: a pilot study. (22473411)
2012
15
Strabismus among aged fee-for-service Medicare beneficiaries. (23158551)
2012
16
On insertion slanting strabismus surgery-reply. (23753980)
2012
17
Botulinum toxin injection into the superior rectus for treatment of strabismus. (22390328)
2012
18
Design and efficacy of surgery for horizontal idiopathic nystagmus with abnormal head posture and strabismus. (22038360)
2011
19
Brief daily periods of unrestricted vision preserve stereopsis in strabismus. (21398285)
2011
20
Philippe de la Hire's description of the mechanism leading to strabismus in 1694. (21635172)
2011
21
Auto-objective accommodative measurements as a valid and reliable new method of pediatric, strabismus and amblyopia, vision screening. (21992058)
2011
22
Effect of vertical transposition of the medial rectus muscle on primary position alignment in infantile esotropia with A- or V-pattern strabismus. (21397800)
2011
23
Diagnosis and surgical treatment of dissociated horizontal deviation strabismus. (21438856)
2011
24
Persistent pupillary membrane, strabismus, and optic nerve hypoplasia in Donnai-Barrow syndrome. (22153411)
2011
25
Fornix-based incision for strabismus surgery: the Parks technique revisited. (21942219)
2011
26
Dexmedetomidine use during strabismus surgery in agitated children. (21757931)
2011
27
Cut and paste: a novel method of reattaching rectus muscles with cyanoacrylate during recessions in strabismus. (21836361)
2011
28
Three Similar But Unique Cases Of Isolated Superior Rectus ExtraOcular Muscle (EOM) Palsy Strabismus, Presenting With Large Abnormal Head Tilts (Postures, AHP). (21992060)
2011
29
Strabismus precipitated by monovision. (21669405)
2011
30
Smoking and strabismus surgery in patients with thyroid eye disease. (21872937)
2011
31
Ketamine and botulinum: a safe combinationfor the management of childhood strabismus. (20230200)
2010
32
Effect of motion stimulation without changing binocular disparity on stereopsis in strabismus patients. (21061889)
2010
33
Another slant on correcting pattern strabismus. (20451850)
2010
34
The prevalence of anisometropia, amblyopia and strabismus in schoolchildren of Shiraz, Iran. (20843187)
2010
35
Investigation of parent-of-origin effect in comitant strabismus using MOD score analysis. (19597570)
2009
36
Sub-Tenon's space abscess after strabismus surgery. (19157934)
2009
37
Acquired restrictive strabismus and high axial myopia: diagnosis and management. (19606166)
2009
38
Effects of innervational strabismus surgery on a patient with hypotropic strabismus and pseudoblepharoptosis. (19807688)
2009
39
Photographic assessment of changes in torsional strabismus. (20006824)
2009
40
Mini-tenotomy procedure to correct diplopia associated with small-angle strabismus. (20126485)
2009
41
Botulinum toxin for the treatment of strabismus. (19370637)
2009
42
Atypical necrotizing scleritis after strabismus surgery. (18083594)
2008
43
Strabismus in unicoronal synostosis: ipsilateral or contralateral? (17538304)
2007
44
Identification of infants with significant refractive error and strabismus in a population screening program using noncycloplegic videorefraction and orthoptic examination. (12556374)
2003
45
Presbyopia complicating pre-existing strabismus. (12870859)
2003
46
Neuronal correlates of amblyopia in the visual cortex of macaque monkeys with experimental strabismus and anisometropia, by L. Kiorpes, D. Kiper, L. O'Keefe, J. Cavanaugh, and A. Movshon. J neuroscience 18:6411-24, 1998. (11033044)
2000
47
Strabismus surgery in children with MAPbius syndrome. (10675874)
2000
48
Successful strabismus surgery in a child with Moebius syndrome. (8239323)
1993
49
Necrotizing scleritis following strabismus surgery for thyroid ophthalmopathy. (2795412)
1989
50
Orbital cellulitis following strabismus surgery. (3574873)
1987

Genetic Variations for Strabismus

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Expression for genes affiliated with Strabismus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Strabismus

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Pathways for genes affiliated with Strabismus

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37NCBI BioSystems Database
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Pathways related to Strabismus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2FGFR3, FGFR2, HOXB1

Compounds for genes affiliated with Strabismus

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59Tocris Bioscience, 44Novoseek, 11DrugBank
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Compounds related to Strabismus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1su 54025910.5FGFR3, FGFR2
2fiin 1 hydrochloride5910.4FGFR3, FGFR2
3pd 1615705910.4FGFR3, FGFR2
4su54024410.3FGFR2, FGFR3
5Ponatinib 1110.3FGFR3, FGFR2
6pd 17307444 5911.2FGFR3, FGFR2
7palifermin44 1111.0FGFR3, FGFR2

GO Terms for genes affiliated with Strabismus

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16Gene Ontology
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Biological processes related to Strabismus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1membranous septum morphogenesisGO:00314910.5FGFR2, VANGL2
2positive regulation of phospholipase activityGO:01051810.5FGFR3, FGFR2
3negative regulation of mitosisGO:04583910.4FGFR3, FGFR2
4lens fiber cell developmentGO:07030710.4FGFR2, FGFR3
5inner ear morphogenesisGO:04247210.4SOBP, FZD6, FGFR2
6establishment of planar polarityGO:00173610.3VANGL2, FZD6
7phosphatidylinositol-mediated signalingGO:04801510.2GPR143, FGFR3, FGFR2
8digestive tract morphogenesisGO:04854610.2FGFR3, VANGL2
9bone morphogenesisGO:06034910.0FGFR2, FGFR3

Molecular functions related to Strabismus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:01713410.3FGFR3, FGFR2
2fibroblast growth factor-activated receptor activityGO:00500710.0FGFR3, FGFR2

Products for genes affiliated with Strabismus

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  • Antibodies
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Sources for Strabismus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet