MCID: STR077
MIFTS: 40

Streptococcal Toxic-Shock Syndrome malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

Aliases & Descriptions for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 56
Streptococcal Toxic Shock Syndrome 69
Streptococcal Tss 56

Characteristics:

Orphanet epidemiological data:

56
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Orphanet 56 ORPHA99918
UMLS via Orphanet 70 C0343532
ICD10 via Orphanet 34 A48.3

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to neuropathy and rheumatoid arthritis. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Rifampin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include breast, t cells and monocytes.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
id Related Disease Score Top Affiliating Genes
1 neuropathy 29.8 CXCL8 IL6 TNF
2 rheumatoid arthritis 29.6 CXCL8 IL2 IL6 LTA TNF
3 toxic shock syndrome 11.7
4 fasciitis 10.4
5 necrotizing fasciitis 10.3
6 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
7 dyslexia 5 10.2 IL6 TNF
8 aortic atherosclerosis 10.2 IL6 TNF
9 degenerative disc disease 10.2 IL6 TNF
10 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
11 swine influenza 10.2 IL6 TNF
12 transient tic disorder 10.2 IL6 TNF
13 anal paget's disease 10.2 IL6 TNF
14 papilledema 10.2 IL6 TNF
15 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 IL6 TNF
16 spondylometaphyseal dysplasia east-african type 10.2 LTA TNF
17 aortic coarctation 10.2 IL6 TNF
18 preaxial polydactyly of fingers 10.2 IL6 TNF
19 human immunodeficiency virus infectious disease 10.2 IL6 TNF
20 idiopathic hypertrophic pachymeningitis 10.2 LTA TNF
21 vogt-koyanagi-harada disease 10.2 IL6 TNF
22 oculomotor nerve paralysis 10.2 CXCL8 IL6
23 common peroneal nerve lesion 10.2 CXCL8 IL6
24 measles 10.2 IL6 TNF
25 vestibule of mouth cancer 10.2 LTA TNF
26 kaposiform hemangioendothelioma 10.2 IL2 LTA
27 kernicterus due to isoimmunization 10.2 LTA TNF
28 neonatal hypoxic and ischemic brain injury 10.2 CXCL8 IL6
29 psychotic disorder 10.2 CXCL8 IL6
30 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL6 TNF
31 schwannoma of ureter 10.2 CXCL8 IL6
32 retinal vascular disease 10.2 CXCL8 IL6
33 childhood electroclinical syndrome 10.2 CXCL8 IL6
34 joint disorders 10.2 IL6 TNF
35 steroid dehydrogenase deficiency dental anomalies 10.2 IL6 TNF
36 laryngotracheoesophageal cleft type 2 10.2 IL2 IL6
37 phlyctenulosis 10.2 IL6 TNF
38 cauda equina syndrome 10.2 LTA TNF
39 acute panmyelosis with myelofibrosis 10.2 CXCL8 IL6
40 mikulicz disease 10.2 IL6 TNF
41 conduct disorder 10.2 IL6 TNF
42 steatitis 10.2 IL2 TNF
43 larynx carcinoma in situ 10.2 CXCL8 IL6
44 pancreatic signet ring cell adenocarcinoma 10.2 IL6 TNF
45 bullous retinoschisis 10.2 CXCL8 IL6
46 carbuncle 10.2 CXCL8 IL6
47 benign neonatal seizures 10.2 IL6 TNF
48 autosomal dominant deafness-onychodystrophy syndrome 10.2 IL2 TNF
49 conidiobolomycosis 10.2 CXCL8 TNF
50 vitreoretinopathy, neovascular inflammatory 10.2 CXCL8 IL6

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4 13292-46-1 5458213 5381226
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Pharmaceutical Solutions Phase 4,Phase 2
7 Immunoglobulins Phase 4,Phase 2
8 gamma-Globulins Phase 4,Phase 2
9 Immunoglobulins, Intravenous Phase 4,Phase 2
10 Rho(D) Immune Globulin Phase 4,Phase 2
11 Antibodies Phase 4,Phase 2
12
Imidacloprid Phase 4 105827-78-9 86418
13 Clavulanic Acid Phase 4
14 Clindamycin palmitate Phase 4
15 Clindamycin phosphate Phase 4
16 Amoxicillin-Potassium Clavulanate Combination Phase 4
17 beta-Lactamase Inhibitors Phase 4
18 Antibiotics, Antitubercular Phase 4
19 proline Nutraceutical Phase 4
20 methicillin
21 Vaccines

Interventional clinical trials:


id Name Status NCT ID Phase
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4
2 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Recruiting NCT02219165 Phase 2
3 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
4 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
5 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
6 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

39
Breast, T Cells, Monocytes, Skin, Eye, Colon

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 180)
id Title Authors Year
1
Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited. ( 27983484 )
2017
2
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus, United Kingdom. ( 27983491 )
2017
3
Intrauterine device infection causing concomitant streptococcal toxic shock syndrome and pelvic abscess with Actinomyces odontolyticus bacteraemia. ( 26965406 )
2016
4
Profuse watery diarrhoea: An unusual presenting feature of streptococcal toxic shock syndrome. ( 27124845 )
2016
5
Streptococcal Toxic Shock Syndrome: Life Saving Role of Peritoneal Lavage and Drainage. ( 27579001 )
2016
6
A fatal case of streptococcal toxic shock syndrome caused by Streptococcus suis carrying tet (40) and tet (O/W/32/O), Italy. ( 27553071 )
2016
7
Recurrent SDSE bacteraemia resulting in streptococcal toxic shock syndrome in a patient with Noonan syndrome. ( 27485878 )
2016
8
Group A streptococcal toxic shock syndrome secondary to necrotizing pelvic inflammatory disease in a postmenopausal woman. ( 27419069 )
2016
9
Right in Front of Our Eyes: Evolution of Streptococcal Toxic Shock Syndrome with Ischemic Optic Neuropathy. ( 27903001 )
2016
10
Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK. ( 26861052 )
2016
11
Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence. ( 27349341 )
2016
12
Management of primary iliopsoas abscess in an immunocompetent patient followed by streptococcal toxic shock syndrome: A case report. ( 27489682 )
2015
13
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012. ( 25703404 )
2015
14
Streptococcal toxic shock syndrome secondary to group AA Streptococcus vaginitis. ( 26386777 )
2015
15
Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. ( 26025992 )
2015
16
Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient. ( 24464696 )
2014
17
Treatment of postoperative purulent pericarditis and streptococcal toxic shock syndrome by intensive blood purification. ( 25228196 )
2014
18
Phlegmonous gastritis associated with group a streptococcal toxic shock syndrome. ( 25400190 )
2014
19
Necrotizing fasciitis and streptococcal toxic shock syndrome secondary to varicella in a healthy child. ( 25653688 )
2014
20
Cases of death due to serious group A streptococcal toxic shock syndrome in pregnant females in Japan. ( 25194311 )
2014
21
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24780814 )
2014
22
Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study. ( 24928291 )
2014
23
Case of streptococcal toxic shock syndrome caused by rapidly progressive group A hemolytic streptococcal infection during postoperative chemotherapy for cervical cancer. ( 23937219 )
2014
24
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2014
25
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome. ( 25313253 )
2014
26
Streptococcal toxic shock syndrome complicating a peritonsillar abscess. ( 25342572 )
2014
27
A fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis possibly caused by an intramuscular injection. ( 23370754 )
2013
28
Streptococcal Toxic Shock Syndrome. ( 24297338 )
2013
29
Fatal streptococcal toxic shock syndrome from an intrauterine device. ( 23394954 )
2013
30
Streptococcal toxic shock syndrome secondary to a deep neck space infection presenting with no throat or neck symptoms. ( 23709536 )
2013
31
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24112488 )
2013
32
Trivial trauma, lethal outcome: streptococcal toxic shock syndrome presenting to the ED. ( 23702056 )
2013
33
Palpable purpura complicated by streptococcal toxic shock syndrome resulting in limb necrosis and amputation: a case of levamisole and cocaine coingestion. ( 22392427 )
2012
34
A case of streptococcal toxic shock syndrome due to Group G streptococci identified as Streptococcus dysgalactiae subsp. equisimilis. ( 22327489 )
2012
35
Complete genome sequence of Streptococcus pyogenes M1 476, isolated from a patient with streptococcal toxic shock syndrome. ( 22965090 )
2012
36
Travel-related Streptococcal toxic shock syndrome caused by emm type 78 Streptococcus pyogenes. ( 21632896 )
2011
37
Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. ( 21460306 )
2011
38
Saline breast implant fluid collection and reactive arthritis in a patient with streptococcal toxic shock syndrome. ( 21325958 )
2011
39
Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome. ( 21673039 )
2011
40
Systemic cytokine response in moribund mice of streptococcal toxic shock syndrome model. ( 21146602 )
2011
41
Clinical characteristics of children with group A streptococcal toxic shock syndrome admitted to pediatric intensive care units. ( 20981441 )
2011
42
Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS). ( 21223537 )
2011
43
Group A streptococcal toxic shock syndrome with extremely aggressive course in the third trimester. ( 20666956 )
2010
44
Intrauterine fetal demise due to streptococcal toxic shock syndrome: a case report. ( 21077531 )
2010
45
Severe group A streptococcal toxic shock syndrome presenting as primary peritonitis: a case report and brief review of the literature. ( 19914115 )
2010
46
Multi-organ failure in a previously healthy 10-year-old boy: streptococcal toxic shock syndrome (STSS) - a rare differential diagnosis. ( 20556706 )
2010
47
Phlegmonous gastritis and group A streptococcal toxic shock syndrome in a patient following functional endoscopic sinus surgery. ( 20575666 )
2010
48
Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates. ( 20368967 )
2010
49
Neonatal streptococcal toxic shock syndrome caused by Streptococcus dysgalactiae subsp. equisimilis. ( 20879096 )
2010
50
Group A streptococcal toxic shock syndrome from a traumatic myositis. ( 20657633 )
2010

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CXCL8 IL2 IL6 LTA TNF
2
Show member pathways
13.34 CXCL8 IL2 IL6 LTA TNF
3
Show member pathways
13.22 CXCL8 IL2 IL6 LTA TNF
4
Show member pathways
13.17 CXCL8 IL2 IL6 LTA TNF
5
Show member pathways
13.11 CXCL8 IL2 IL6 LTA TNF
6
Show member pathways
12.75 CXCL8 IL2 IL6 TNF
7
Show member pathways
12.64 IL2 IL6 LTA TNF
8
Show member pathways
12.62 CXCL8 IL2 IL6 LTA TNF
9
Show member pathways
12.55 IL2 IL6 LTA TNF
10
Show member pathways
12.55 CXCL8 IL2 IL6 LTA TNF
11
Show member pathways
12.29 IL2 IL6 TNF
12 12.26 IL2 IL6 LTA TNF
13
Show member pathways
12.2 IL2 IL6 TNF
14
Show member pathways
12.2 CXCL8 IL6 TNF
15
Show member pathways
12.14 CXCL8 IL6 TNF
16
Show member pathways
12.13 CXCL8 IL6 TNF
17
Show member pathways
12.06 CXCL8 IL6 TNF
18 12.05 CXCL8 IL6 TNF
19 11.89 IL2 IL6 TNF
20 11.88 CXCL8 IL6 TNF
21 11.85 IL6 LTA TNF
22 11.8 CXCL8 IL6 TNF
23 11.78 CXCL8 IL6 TNF
24 11.78 CXCL8 IL2 IL6 TNF
25 11.77 CXCL8 LTA TNF
26 11.74 CXCL8 IL6 TNF
27
Show member pathways
11.7 CXCL8 IL2 LTA
28 11.69 CXCL8 IL2 IL6
29 11.67 IL2 LTA TNF
30
Show member pathways
11.65 IL2 IL6 LTA TNF
31
Show member pathways
11.64 CXCL8 IL2 TNF
32 11.63 IL2 IL6 TNF
33 11.59 IL6 LTA TNF
34 11.53 CXCL8 IL6 TNF
35 11.45 CXCL8 IL6 TNF
36 11.44 C1S CXCL8 IL6 TNF
37
Show member pathways
11.42 LTA TNF
38 11.41 IL2 IL6 TNF
39 11.4 IL6 TNF
40 11.4 IL2 TNF
41 11.38 CXCL8 IL6 TNF
42 11.37 IL6 TNF
43 11.36 CXCL8 IL6 TNF
44
Show member pathways
11.31 IL2 TNF
45
Show member pathways
11.26 CXCL8 IL2 IL6 TNF
46 11.25 IL6 TNF
47 11.25 IL6 TNF
48 11.23 CXCL8 IL6
49
Show member pathways
11.23 CXCL8 IL2 IL6 LTA TNF
50 11.2 IL6 TNF

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CXCL8 IL2 IL6 LTA TNF
2 extracellular region GO:0005576 9.1 C1S CXCL8 IL2 IL6 LTA TNF

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.75 IL6 LTA TNF
2 cellular response to lipopolysaccharide GO:0071222 9.63 CXCL8 IL6 TNF
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.57 IL2 IL6
4 negative regulation of fat cell differentiation GO:0045599 9.56 IL6 TNF
5 positive regulation of interleukin-6 production GO:0032755 9.55 IL6 TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.54 IL6 LTA TNF
8 embryonic digestive tract development GO:0048566 9.52 CXCL8 TNF
9 positive regulation of chemokine production GO:0032722 9.51 IL6 TNF
10 negative regulation of growth of symbiont in host GO:0044130 9.49 LTA TNF
11 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL2 IL6
12 negative regulation of lipid storage GO:0010888 9.43 IL6 TNF
13 humoral immune response GO:0006959 9.43 IL6 LTA TNF
14 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.4 IL6 TNF
15 positive regulation of interferon-gamma production GO:0032729 9.33 IL2 LTA TNF
16 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 LTA TNF
17 immune response GO:0006955 9.02 CXCL8 IL2 IL6 LTA TNF
18 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL2 IL6 LTA TNF
2 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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