MCID: STR077
MIFTS: 36

Streptococcal Toxic-Shock Syndrome malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 51
Streptococcal Toxic Shock Syndrome 65
 
Streptococcal Tss 51

Classifications:



External Ids:

Orphanet51 99918
ICD10 via Orphanet28 A48.3
UMLS via Orphanet66 C0343532
UMLS65 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

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MalaCards based summary: Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to hemolytic anemia and toxic shock syndrome. An important gene associated with Streptococcal Toxic-Shock Syndrome is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and ATF-2 transcription factor network. Affiliated tissues include colon, thyroid and myeloid.

Related Diseases for Streptococcal Toxic-Shock Syndrome

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Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia30.3IL6, TNF
2toxic shock syndrome10.7
3neuronitis10.5
4hepatitis10.5
5leukemia10.5
6arthritis10.4
7cervicitis10.4
8cerebritis10.4
9endotheliitis10.4
10rheumatoid arthritis10.3
11colorectal cancer10.3
12myocardial infarction10.3
13lung cancer10.3
14breast cancer10.3
15obesity10.3
16cerebral hemorrhage10.3
17cutaneous leishmaniasis10.3
18lymphoma10.3
19folliculitis10.3
20influenza10.3
21leishmaniasis10.3
22meningitis10.3
23corneal abscess10.3CXCL8, IL6
24neonatal period electroclinical syndrome10.3CXCL8, IL6
25osteogenesis imperfecta, type x10.3CXCL8, IL6
26optic neuritis10.3CXCL8, IL6
27eyelid neoplasm10.3CXCL8, IL6
28narcissistic personality disorder10.3CXCL8, IL6
29scrotum squamous cell carcinoma10.3CXCL8, IL6
30blue toe syndrome10.3CXCL8, IL6
31endocarditis10.3CXCL8, IL6
32aggressive digital papillary adenocarcinoma10.3CXCL8, IL6
33alcoholic gastritis10.3CXCL8, IL6
34psychologic dyspareunia10.2CXCL8, IL6
35cutaneous paget's disease10.2CXCL8, IL6
36hidrocystoma10.2CXCL8, IL6
37adult t-cell leukemia10.2CXCL8, IL6
38retinitis pigmentosa10.2CXCL8, IL6
39xanthogranulomatous pyelonephritis10.2CXCL8, IL6
40adult spinal cord glioblastoma multiforme10.2CXCL8, IL6
41childhood kidney angiomyolipoma10.2CXCL8, IL6
42fat necrosis of breast10.2CXCL8, IL6
43retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities10.2CXCL8, IL6
44gastrointestinal stromal tumor10.2
45neuroblastoma10.2
46hiv-110.2
47prostate cancer10.2
48hepatocellular carcinoma10.2
49hodgkin lymphoma10.2
50attention deficit-hyperactivity disorder10.2

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to streptococcal toxic-shock syndrome

Symptoms for Streptococcal Toxic-Shock Syndrome

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Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

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Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 24477
2Rho(D) Immune GlobulinPhase 2206
3Immunologic FactorsPhase 218483
4Pharmaceutical SolutionsPhase 27004
5Immunoglobulins, IntravenousPhase 2211
6ImmunoglobulinsPhase 24477
7methicillin148
8Anti-Infective Agents17220
9Vaccines6085
10Anti-Bacterial Agents9140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot StudyRecruitingNCT02219165Phase 2
2Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital TractCompletedNCT00299663
3Surveillance of Streptococcal Infections in Children in IndiaCompletedNCT00342199
4Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus AureusCompletedNCT01141101
5Severe Soft Tissue Infections: Perspectives of Patients and Significant OthersRecruitingNCT02169128

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

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Anatomical Context for Streptococcal Toxic-Shock Syndrome

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MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

33
Colon, Thyroid, Myeloid, Monocytes, Liver, Breast, Heart

Animal Models for Streptococcal Toxic-Shock Syndrome or affiliated genes

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Publications for Streptococcal Toxic-Shock Syndrome

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Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila. (25447237)
2015
2
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. (25348003)
2014
3
The T309G MDM2 Gene Polymorphism Is a Novel Risk Factor for Proliferative Vitreoretinopathy. (24349246)
2013
4
Successful radiofrequency ablation of an anterior abdominal wall desmoid in familial adenomatous polyposis. (23067141)
2013
5
Prevalence of goiter and urinary iodine status in six-twelve-year-old rural primary school children of bharuch district, gujarat, India. (22355478)
2012
6
Role of CEUS in the diagnosis of gallbladder disease. (23243646)
2012
7
Lactulose in the treatment of hepatic encephalopathy: new evidence for an old modality. (22823914)
2012
8
Management of adult onset orbital hemangioma by oral propranalol: a case report. (22877318)
2012
9
Angiotensinogen gene polymorphism in acute myocardial infarction patients. (20663844)
2011
10
Genetic association of recovery from eating disorders: the role of GABA receptor SNPs. (21750581)
2011
11
Dissociation of epidermal growth factor receptor and ErbB2 heterodimers in the presence of somatostatin receptor 5 modulate signaling pathways. (21190959)
2011
12
Visual electrophysiological findings in CHARGE syndrome with bilateral colobomas: a case report. (20213536)
2010
13
IL1/IL1 Ra, CTLA-4 and Apo1/Fas genes polymorphisms and susceptibility to IgA nephropathy in Tunisian patients]. (21049406)
2010
14
Paraoxonase 1 protects against protein N-homocysteinylation in humans. (19880629)
2010
15
Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer. (20816508)
2010
16
A phase I clinical study of intratumorally administered VB4-845, an anti-epithelial cell adhesion molecule recombinant fusion protein, in patients with squamous cell carcinoma of the head and neck. (19016010)
2009
17
Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B. (19053775)
2008
18
Beneficial effects of carvedilol as a concomitant therapy to angiotensin-converting enzyme inhibitor in patients with ischemic left ventricular systolic dysfunction. (17487260)
2007
19
Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis. (17482523)
2007
20
Relationship between dopamine system genes and extraversion and novelty seeking. (17657431)
2007
21
Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease. (17229472)
2007
22
AIDS dementia complex in China. (17070055)
2007
23
Oligodendrocyte lineage transcription factor 2 inhibits the motility of a human glial tumor cell line by activating RhoA. (17951409)
2007
24
Hepatic and neuromuscular forms of glycogenosis type III: nine mutations in AGL. (16705713)
2006
25
Interactions between the RNA interference effector protein Ago1 and 14-3-3 proteins: consequences for cell cycle progression. (17043360)
2006
26
Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons. (15837568)
2005
27
Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens. (15664664)
2005
28
Characteristic patterns of N Oct-3 binding to a set of neuronal promoters. (15178247)
2004
29
A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb. (14990566)
2004
30
IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. (14530367)
2003
31
An outbreak of travel-associated Legionnaires disease and Pontiac fever: the need for enhanced surveillance of travel-associated legionellosis in the United States. (11807698)
2002
32
Changes in hip spasticity and strength following selective dorsal rhizotomy and physical therapy for spastic cerebral palsy. (11995889)
2002
33
Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. (12232053)
2002
34
Effect of highly active antiretroviral therapy on the incidence of HIV-related cytomegalovirus retinitis and retinal detachment. (10935050)
2000
35
Systemic mastocytosis: MRI of bone marrow involvement. (10415240)
1999
36
Assessment of the gonadotrophin-gonadal axis in androgen insensitivity syndrome. (10086936)
1999
37
Fetal neurenteric cyst causing hydrops: case report and review of the literature. (10215067)
1999
38
Effect of niacin supplementation on fibrinogen levels in patients with peripheral vascular disease. (9732910)
1998
39
Hypercalcemia in children with rhabdomyosarcoma. (9703006)
1998
40
Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. (9762928)
1998
41
Relationship between glucocorticoid receptor and response to glucocorticoid therapy in ulcerative colitis. (9378013)
1997
42
Comparison of plasma erythropoietin concentrations and iron status in hemodialyzed patients not requiring and requiring rHuEpo therapy. (8832602)
1996
43
AxCAMs and DenCAMs: a novel classification of neuronal cell recognition/adhesion molecules--with special reference to a telencephalon-specific glycoprotein, telencephalin]. (7886240)
1995
44
Length polymorphism of the human complement component C4 gene is due to an ancient retroviral integration. (7576718)
1995
45
Nesidiodysplasia: an unusual cause of hyperinsulinemic hypoglycemia in adults. (7911361)
1993
46
Expression of recombinant dystrophin and its localization to the cell membrane. (1824797)
1991
47
Translocation t(5;11)(q13.1;p13) associated with familial isolated aniridia. (2817003)
1989
48
Lymphopenia after snakebite. (2574373)
1989
49
Monoclonal antibody MCS-2 as the marker of phorbol diester-induced myeloid differentiation in acute undifferentiated leukemia. (6372996)
1984
50
SPONTANEOUS CORONARY ARTERIOSCLEROSIS IN REPEATEDLY BRED MALE AND FEMALE RATS. (14104162)
1964

Variations for Streptococcal Toxic-Shock Syndrome

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Expression for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathwaysScoreTop Affiliating Genes
19.5CXCL8, IL6
29.5CXCL8, IL6
39.5CXCL8, IL6
49.5CXCL8, IL6
59.2CXCL8, TNF
69.1IL6, TNF
79.1IL6, TNF
89.1IL6, TNF
99.1IL6, TNF
109.1IL6, TNF
11
Show member pathways
9.0LTA, TNF
129.0LTA, TNF
13
Show member pathways
8.7CXCL8, IL6, TNF
14
Show member pathways
8.7CXCL8, IL6, TNF
15
Show member pathways
8.7CXCL8, IL6, TNF
16
Show member pathways
8.7CXCL8, IL6, TNF
178.7CXCL8, IL6, TNF
188.7CXCL8, IL6, TNF
198.7CXCL8, IL6, TNF
208.7CXCL8, IL6, TNF
218.7CXCL8, IL6, TNF
228.7CXCL8, IL6, TNF
238.7CXCL8, IL6, TNF
24
Show member pathways
8.7CXCL8, IL6, TNF
258.7CXCL8, IL6, TNF
268.6CXCL8, LTA, TNF
27
Show member pathways
8.5IL6, LTA, TNF
28
Show member pathways
8.5IL6, LTA, TNF
298.5IL6, LTA, TNF
308.5IL6, LTA, TNF
318.5IL6, LTA, TNF
328.3C1S, CXCL8, IL6, TNF
33
Show member pathways
8.1CXCL8, IL6, LTA, TNF
34
Show member pathways
8.1CXCL8, IL6, LTA, TNF
35
Show member pathways
8.1CXCL8, IL6, LTA, TNF

GO Terms for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.8IL6, TNF
2positive regulation of nitric oxide biosynthetic processGO:00454299.7IL6, TNF
3embryonic digestive tract developmentGO:00485669.7CXCL8, TNF
4positive regulation of chronic inflammatory response to antigenic stimulusGO:00028769.6LTA, TNF
5negative regulation of lipid storageGO:00108889.6IL6, TNF
6negative regulation of fat cell differentiationGO:00455999.5IL6, TNF
7response to glucocorticoidGO:00513849.5IL6, TNF
8positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL6, TNF
9positive regulation of peptidyl-serine phosphorylationGO:00331389.4IL6, TNF
10positive regulation of protein kinase B signalingGO:00518979.4IL6, TNF
11positive regulation of interferon-gamma productionGO:00327299.4LTA, TNF
12positive regulation of smooth muscle cell proliferationGO:00486619.4IL6, TNF
13positive regulation of interleukin-6 productionGO:00327559.2IL6, TNF
14defense response to Gram-positive bacteriumGO:00508309.0IL6, LTA, TNF
15cellular response to lipopolysaccharideGO:00712228.7CXCL8, IL6, TNF
16positive regulation of apoptotic processGO:00430658.5IL6, LTA, TNF
17immune responseGO:00069558.4CXCL8, IL6, TNF

Sources for Streptococcal Toxic-Shock Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet