MCID: STR077
MIFTS: 33

Streptococcal Toxic-Shock Syndrome malady

Infectious diseases, Rare diseases categories

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 51
Streptococcal Toxic Shock Syndrome 65
 
Streptococcal Tss 51


Classifications:



External Ids:

Orphanet51 99918
ICD10 via Orphanet28 A48.3
UMLS via Orphanet66 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

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MalaCards based summary: Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to rheumatoid arthritis and keratitis. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways are IL-10 Pathway and amb2 Integrin signaling. Affiliated tissues include colon, t cells and breast.

Related Diseases for Streptococcal Toxic-Shock Syndrome

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Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis30.5CXCL8, IL2, IL6, TNF
2keratitis30.5CXCL8, IL6, TNF
3toxic shock syndrome11.4
4fasciitis10.8
5necrotizing fasciitis10.8
6arthritis10.6
7peritonitis10.6
8scarlet fever10.4
9gastritis10.4
10myositis10.4
11breast reconstruction10.3
12pharyngitis10.3
13acute pancreatitis10.3
14herpes zoster10.3
15hypoglycemia10.3
16reactive arthritis10.3
17pyomyositis10.3
18anterior scleritis10.3
19cellulitis10.3
20cervicitis10.3
21cholecystitis10.3
22impetigo10.3
23pancreatitis10.3
24pericarditis10.3
25purpura10.3
26salpingitis10.3
27scleritis10.3
28thrombophlebitis10.3
29vaginitis10.3
30bullous impetigo10.3
31crohn's disease10.2IL6, TNF
32aorta atresia10.2IL6, TNF
33larynx sarcoma10.2IL6, TNF
34glycogen storage disease viii10.2IL6, TNF
35wissler's syndrome10.2IL6, TNF
36t cell immunodeficiency primary10.2IL6, TNF
37epithelioid malignant peripheral nerve sheath tumor10.2IL6, LTA
38anti-hla hyperimmunization10.2IL6, TNF
39posterior valve urethra10.2IL6, TNF
40treponema infection10.2IL6, TNF
41testicular leukemia10.2IL6, TNF
42fallopian tube cystadenofibroma10.2IL6, TNF
43stalker chitayat syndrome10.2IL6, TNF
44listeriosis10.2LTA, TNF
45ischemic optic neuropathy10.2IL6, TNF
46benign lymphoepithelial lesion of salivary gland10.2IL6, TNF
47neurotic excoriation10.2LTA, TNF
48lacrimal gland adenocarcinoma10.2IL6, TNF
49hemorrhagic proctocolitis10.2IL6, TNF
50intermediate dend syndrome10.2IL6, TNF

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to streptococcal toxic-shock syndrome

Symptoms for Streptococcal Toxic-Shock Syndrome

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Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

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Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins, IntravenousPhase 2203
2Rho(D) Immune GlobulinPhase 2198
3methicillin142

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot StudyRecruitingNCT02219165Phase 2
2Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital TractCompletedNCT00299663
3Surveillance of Streptococcal Infections in Children in IndiaCompletedNCT00342199
4Severe Soft Tissue Infections: Perspectives of Patients and Significant OthersRecruitingNCT02169128
5Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus AureusRecruitingNCT01141101

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

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Anatomical Context for Streptococcal Toxic-Shock Syndrome

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MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

33
Colon, T cells, Breast, Monocytes

Animal Models for Streptococcal Toxic-Shock Syndrome or affiliated genes

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Publications for Streptococcal Toxic-Shock Syndrome

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Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. (26025992)
2015
2
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012. (25703404)
2015
3
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome. (25313253)
2014
4
Treatment of postoperative purulent pericarditis and streptococcal toxic shock syndrome by intensive blood purification. (25228196)
2014
5
Streptococcal toxic shock syndrome following total thyroidectomy. (24112488)
2013
6
Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. (21460306)
2011
7
Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates. (20368967)
2010
8
Phlegmonous gastritis and group A streptococcal toxic shock syndrome in a patient following functional endoscopic sinus surgery. (20575666)
2010
9
Necrotizing fascitis and streptococcal toxic shock syndrome complicating herpes zoster: a vaccine talking point? (21246167)
2009
10
Intravenous immunoglobulin in children with streptococcal toxic shock syndrome. (19788359)
2009
11
Streptococcal toxic shock syndrome following insertion of an intrauterine device--a case report. (19916766)
2009
12
Puerperal streptococcal toxic shock syndrome treated with recombinant human activated protein C and intravenous immunoglobulin. (19195874)
2009
13
Bacterial phenotype variants in group B streptococcal toxic shock syndrome. (19193266)
2009
14
A fatal case of streptococcal toxic shock syndrome. (18453517)
2008
15
Fatal streptococcal toxic shock syndrome in a child with varicella and necrotizing fasciitis of the face. (19078822)
2008
16
Puerperal widespread pyomyositis after group A streptococcal toxic shock syndrome. (18669156)
2008
17
Spontaneous perforation of the cystic duct in streptococcal toxic shock syndrome: a case report. (18959771)
2008
18
Bullous impetigo: a rare presentation in fulminant streptococcal toxic shock syndrome. (17505275)
2007
19
A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. (17375201)
2007
20
Sudden unexpected death in a child with varicella caused by necrotizing fasciitis and streptococcal toxic shock syndrome. (16501360)
2006
21
Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome. (16912949)
2006
22
Streptococcal toxic shock syndrome with initial manifestation of abdominal pain and cholecystitis. (16302590)
2005
23
Fatal streptococcal toxic shock syndrome in a patient with rheumatoid arthritis treated with etanercept. (15870144)
2005
24
Diffuse venous thromboemboli associated with IVIg therapy in the treatment of streptococcal toxic shock syndrome: case report and review. (15815906)
2005
25
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
26
Streptococcal toxic shock syndrome presenting with spontaneous hypoglycemia in a chronic hemodialysis patient: pathophysiological mechanisms. (12793713)
2003
27
Streptococcal toxic shock syndrome manifesting as peritonitis in a child. (12353345)
2002
28
Group A streptococcal toxic shock syndrome developing in the third trimester of pregnancy. (12648315)
2002
29
Streptococcal toxic shock syndrome: a description of 14 cases from North Yorkshire, UK. (12010172)
2002
30
Streptococcal toxic shock syndrome. (12010167)
2002
31
A family cluster of streptococcal toxic shock syndrome in children: clinical implication and epidemiological investigation. (11331706)
2001
32
Kallikrein-kinin system activation in streptococcal toxic shock syndrome. (10880316)
2000
33
Human bite on penile shaft from oral sex as a portal of entry for streptococcal toxic shock syndrome. (11344784)
2000
34
Severe group A streptococcal infection and streptococcal toxic shock syndrome. (11097546)
2000
35
Intravenous immunoglobulin as adjunctive treatment for streptococcal toxic shock syndrome associated with necrotizing fasciitis: case report and review. (10610017)
1999
36
Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome--a comparative observational study. The Canadian Streptococcal Study Group. (10825042)
1999
37
Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome. (9868656)
1998
38
Rationale for the use of intravenous gamma globulin in the treatment of streptococcal toxic shock syndrome. (9524836)
1998
39
Update on canine streptococcal toxic shock syndrome and necrotizing fasciitis. (9105725)
1997
40
Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates. (9393817)
1997
41
Acute group G streptococcal myositis associated with streptococcal toxic shock syndrome: case report and review. (8922817)
1996
42
Streptococcal toxic shock syndrome in a postpartum woman. Case report and review of the literature. (8740114)
1996
43
Detection of circulating bacterial superantigen and lymphotoxin-alpha in patients with streptococcal toxic-shock syndrome. (8909404)
1996
44
Streptococcal toxic shock syndrome from a puncture wound to the foot. (8986898)
1996
45
Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. (8903167)
1995
46
Clinical and microbiological characteristics of severe group A streptococcus infections and streptococcal toxic shock syndrome. (8562741)
1995
47
Case report: streptococcal toxic shock syndrome presenting as septic thrombophlebitis in a child with varicella. (8108215)
1993
48
Streptococcal toxic shock syndrome in children. (1644967)
1992
49
Pediatric streptococcal toxic shock syndrome. (1513730)
1992
50
Streptococcal toxic shock syndrome due to noninvasive pharyngitis. (1600009)
1992

Variations for Streptococcal Toxic-Shock Syndrome

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Expression for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL6, TNF
29.6IL6, TNF
39.6IL6, TNF
49.6IL6, TNF
5
Show member pathways
9.6LTA, TNF
69.6CXCL8, IL6
79.6CXCL8, IL6
89.5IL2, LTA
99.5CXCL8, TNF
10
Show member pathways
9.5IL2, TNF
11
AhR pathway (WikiPathways)
Show member pathways
9.5IL2, TNF
129.2IL6, LTA, TNF
13
Show member pathways
9.1CXCL8, IL6, TNF
149.1CXCL8, IL6, TNF
159.1CXCL8, IL6, TNF
169.1CXCL8, IL6, TNF
179.1CXCL8, IL6, TNF
18
Show member pathways
9.1CXCL8, IL6, TNF
19
Show member pathways
9.1CXCL8, IL6, TNF
209.1CXCL8, IL6, TNF
21
Show member pathways
9.1IL2, IL6, TNF
229.1IL2, IL6, TNF
239.1CXCL8, LTA, TNF
249.1CXCL8, IL2, IL6
25
Show member pathways
9.0CXCL8, IL2, LTA
26
Show member pathways
9.0CXCL8, IL2, TNF
27
Show member pathways
8.7IL2, IL6, LTA, TNF
28
Show member pathways
8.7IL2, IL6, LTA, TNF
29
Show member pathways
8.7IL2, IL6, LTA, TNF
308.7IL2, IL6, LTA, TNF
31
Show member pathways
8.7IL2, IL6, LTA, TNF
328.6CXCL8, IL2, IL6, TNF
33
Show member pathways
8.6CXCL8, IL2, IL6, TNF
348.6CXCL8, IL2, IL6, TNF
358.3C1S, CXCL8, IL6, TNF
36
Show member pathways
8.2CXCL8, IL2, IL6, LTA, TNF
37
Show member pathways
8.2CXCL8, IL2, IL6, LTA, TNF
38
Show member pathways
8.2CXCL8, IL2, IL6, LTA, TNF
39
Show member pathways
8.2CXCL8, IL2, IL6, LTA, TNF
40
Show member pathways
8.2CXCL8, IL2, IL6, LTA, TNF

GO Terms for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.2CXCL8, IL2, IL6, LTA, TNF
2extracellular regionGO:00055767.5C1S, CXCL8, IL2, IL6, TNF

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.3LTA, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3IL6, TNF
3negative regulation of lipid storageGO:001088810.2IL6, TNF
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.2LTA, TNF
5positive regulation of chemokine productionGO:003272210.2IL6, TNF
6negative regulation of fat cell differentiationGO:004559910.2IL6, TNF
7positive regulation of immunoglobulin secretionGO:005102410.1IL2, IL6
8negative regulation of growth of symbiont in hostGO:004413010.0LTA, TNF
9positive regulation of interleukin-6 productionGO:00327559.8IL6, TNF
10positive regulation of smooth muscle cell proliferationGO:00486619.8IL6, TNF
11embryonic digestive tract developmentGO:00485669.8CXCL8, TNF
12humoral immune responseGO:00069599.7IL6, LTA, TNF
13positive regulation of nitric oxide biosynthetic processGO:00454299.6IL6, TNF
14positive regulation of interferon-gamma productionGO:00327299.6IL2, LTA, TNF
15cellular response to lipopolysaccharideGO:00712229.4CXCL8, IL6, TNF
16defense response to Gram-positive bacteriumGO:00508309.2IL6, LTA, TNF
17positive regulation of apoptotic processGO:00430659.1IL6, LTA, TNF
18immune responseGO:00069558.3CXCL8, IL2, IL6, LTA, TNF

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.8LTA, TNF
2cytokine activityGO:00051258.7IL2, IL6, LTA, TNF

Sources for Streptococcal Toxic-Shock Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet