MCID: STR077
MIFTS: 40

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 55
Streptococcal Toxic Shock Syndrome 69
Streptococcal Tss 55

Characteristics:

Orphanet epidemiological data:

55
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Orphanet 55 ORPHA99918
UMLS via Orphanet 70 C0343532
ICD10 via Orphanet 33 A48.3
UMLS 69 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to fasciitis and peritonitis. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and skin.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 fasciitis 30.7 CXCL8 IL6 TNF
2 peritonitis 30.4 CXCL8 IL6 TNF
3 vaginitis 30.3 CXCL8 IL6
4 pericarditis 30.1 IL6 TNF
5 reactive arthritis 30.1 IL6 TNF
6 impetigo 30.0 IL6 MYOM2
7 arthritis 29.9 CXCL8 IL6 LTA TNF
8 pharyngitis 29.7 CXCL8 MYOM2
9 rheumatoid arthritis 29.6 CXCL8 IL2 IL6 TNF
10 necrotizing fasciitis 29.2 CXCL8 IL2 IL6 LTA MYOM2
11 toxic shock syndrome 28.9 C1S CXCL8 IL2 IL6 LTA MYOM2
12 staphylococcal toxic shock syndrome 11.4
13 scorpion envenomation 10.4 IL6 TNF
14 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
15 critical limb ischemia 10.4 IL6 TNF
16 retinitis pigmentosa 55 10.4 IL6 TNF
17 glossitis 10.4 IL6 TNF
18 laryngitis 10.4 IL6 TNF
19 anterior uveitis 10.4 IL6 TNF
20 acute vascular insufficiency of intestine 10.4 IL6 TNF
21 posterior urethral valves 10.3 IL6 TNF
22 central nervous system vasculitis 10.3 IL6 TNF
23 stachybotrys chartarum 10.3 IL6 TNF
24 spondylarthropathy 10.3 LTA TNF
25 transient hypogammaglobulinemia 10.3 LTA TNF
26 listeriosis 10.3 IL6 TNF
27 crimean-congo hemorrhagic fever 10.3 IL6 TNF
28 ischemic heart disease 10.3 IL6 TNF
29 eales disease 10.3 IL6 TNF
30 hemorrhagic fever 10.3 IL6 TNF
31 mucocutaneous leishmaniasis 10.3 LTA TNF
32 idiopathic achalasia 10.3 LTA TNF
33 recurrent corneal erosion 10.3 CXCL8 IL6
34 myelitis 10.3 IL6 TNF
35 bagassosis 10.3 CXCL8 IL6
36 nonalcoholic steatohepatitis 10.3 IL6 TNF
37 listeria meningitis 10.3 LTA TNF
38 stromal keratitis 10.3 IL6 TNF
39 sympathetic ophthalmia 10.3 LTA TNF
40 acute transverse myelitis 10.3 CXCL8 IL6
41 extramedullary plasmacytoma 10.3 IL2 IL6
42 endometritis 10.3 IL6 TNF
43 immune suppression 10.3 IL2 IL6
44 juvenile spondyloarthropathy 10.3 IL2 LTA
45 denture stomatitis 10.3 CXCL8 IL6
46 papillary conjunctivitis 10.3 CXCL8 IL6
47 funisitis 10.3 CXCL8 IL6
48 uremic pruritus 10.3 IL2 IL6
49 rosacea 10.3 IL6 TNF
50 joint disorders 10.3 IL6 TNF

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
2 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
3 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

38
T Cells, Monocytes, Skin, Colon, Eye

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 190)
# Title Authors Year
1
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. ( 29107650 )
2018
2
Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited. ( 27983484 )
2017
3
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
4
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
5
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
6
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
7
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2017
8
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus, United Kingdom. ( 27983491 )
2017
9
Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report. ( 28762570 )
2017
10
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. ( 29254479 )
2017
11
Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. ( 28698738 )
2017
12
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. ( 28954758 )
2017
13
Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence. ( 27349341 )
2016
14
Right in Front of Our Eyes: Evolution of Streptococcal Toxic Shock Syndrome with Ischemic Optic Neuropathy. ( 27903001 )
2016
15
Intrauterine device infection causing concomitant streptococcal toxic shock syndrome and pelvic abscess with Actinomyces odontolyticus bacteraemia. ( 26965406 )
2016
16
Streptococcal Toxic Shock Syndrome: Life Saving Role of Peritoneal Lavage and Drainage. ( 27579001 )
2016
17
Profuse watery diarrhoea: An unusual presenting feature of streptococcal toxic shock syndrome. ( 27124845 )
2016
18
A fatal case of streptococcal toxic shock syndrome caused by Streptococcus suis carrying tet (40) and tet (O/W/32/O), Italy. ( 27553071 )
2016
19
Group A streptococcal toxic shock syndrome secondary to necrotizing pelvic inflammatory disease in a postmenopausal woman. ( 27419069 )
2016
20
Recurrent SDSE bacteraemia resulting in streptococcal toxic shock syndrome in a patient with Noonan syndrome. ( 27485878 )
2016
21
Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK. ( 26861052 )
2016
22
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012. ( 25703404 )
2015
23
Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. ( 26025992 )
2015
24
Streptococcal toxic shock syndrome secondary to group AA Streptococcus vaginitis. ( 26386777 )
2015
25
Management of primary iliopsoas abscess in an immunocompetent patient followed by streptococcal toxic shock syndrome: A case report. ( 27489682 )
2015
26
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24780814 )
2014
27
Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient. ( 24464696 )
2014
28
Phlegmonous gastritis associated with group a streptococcal toxic shock syndrome. ( 25400190 )
2014
29
Streptococcal toxic shock syndrome complicating a peritonsillar abscess. ( 25342572 )
2014
30
Necrotizing fasciitis and streptococcal toxic shock syndrome secondary to varicella in a healthy child. ( 25653688 )
2014
31
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome. ( 25313253 )
2014
32
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2014
33
Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study. ( 24928291 )
2014
34
Cases of death due to serious group A streptococcal toxic shock syndrome in pregnant females in Japan. ( 25194311 )
2014
35
Treatment of postoperative purulent pericarditis and streptococcal toxic shock syndrome by intensive blood purification. ( 25228196 )
2014
36
Case of streptococcal toxic shock syndrome caused by rapidly progressive group A hemolytic streptococcal infection during postoperative chemotherapy for cervical cancer. ( 23937219 )
2014
37
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24112488 )
2013
38
Fatal streptococcal toxic shock syndrome from an intrauterine device. ( 23394954 )
2013
39
Streptococcal Toxic Shock Syndrome. ( 24297338 )
2013
40
A fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis possibly caused by an intramuscular injection. ( 23370754 )
2013
41
Streptococcal toxic shock syndrome secondary to a deep neck space infection presenting with no throat or neck symptoms. ( 23709536 )
2013
42
Trivial trauma, lethal outcome: streptococcal toxic shock syndrome presenting to the ED. ( 23702056 )
2013
43
A case of streptococcal toxic shock syndrome due to Group G streptococci identified as Streptococcus dysgalactiae subsp. equisimilis. ( 22327489 )
2012
44
Complete genome sequence of Streptococcus pyogenes M1 476, isolated from a patient with streptococcal toxic shock syndrome. ( 22965090 )
2012
45
Palpable purpura complicated by streptococcal toxic shock syndrome resulting in limb necrosis and amputation: a case of levamisole and cocaine coingestion. ( 22392427 )
2012
46
Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome. ( 21673039 )
2011
47
Systemic cytokine response in moribund mice of streptococcal toxic shock syndrome model. ( 21146602 )
2011
48
Travel-related Streptococcal toxic shock syndrome caused by emm type 78 Streptococcus pyogenes. ( 21632896 )
2011
49
Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. ( 21460306 )
2011
50
Saline breast implant fluid collection and reactive arthritis in a patient with streptococcal toxic shock syndrome. ( 21325958 )
2011

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CXCL8 IL2 IL6 LTA TNF
2
Show member pathways
13.34 CXCL8 IL2 IL6 LTA TNF
3
Show member pathways
13.22 CXCL8 IL2 IL6 LTA TNF
4
Show member pathways
13.17 CXCL8 IL2 IL6 LTA TNF
5
Show member pathways
13.12 CXCL8 IL2 IL6 LTA TNF
6
Show member pathways
12.64 IL2 IL6 LTA TNF
7
Show member pathways
12.62 CXCL8 IL2 IL6 LTA TNF
8
Show member pathways
12.56 IL2 IL6 LTA TNF
9
Show member pathways
12.55 CXCL8 IL2 IL6 LTA TNF
10
Show member pathways
12.44 IL2 IL6 TNF
11
Show member pathways
12.42 CXCL8 IL6 TNF
12
Show member pathways
12.37 CXCL8 IL2 IL6 TNF
13
Show member pathways
12.29 IL2 IL6 TNF
14 12.27 IL2 IL6 LTA TNF
15
Show member pathways
12.21 IL2 IL6 TNF
16
Show member pathways
12.2 CXCL8 IL6 TNF
17
Show member pathways
12.15 CXCL8 IL6 TNF
18
Show member pathways
12.14 CXCL8 IL6 TNF
19
Show member pathways
12.07 CXCL8 IL6 TNF
20 12.06 CXCL8 IL6 TNF
21 11.9 IL2 IL6 TNF
22 11.88 CXCL8 IL6 TNF
23 11.86 IL6 LTA TNF
24 11.81 CXCL8 IL6 TNF
25 11.79 CXCL8 IL6 TNF
26 11.78 CXCL8 LTA TNF
27 11.78 CXCL8 IL2 IL6 TNF
28 11.75 CXCL8 IL6 TNF
29
Show member pathways
11.71 CXCL8 IL2 LTA
30 11.7 CXCL8 IL2 IL6
31 11.68 IL2 LTA TNF
32
Show member pathways
11.66 CXCL8 IL2 TNF
33 11.64 IL2 IL6 TNF
34
Show member pathways
11.64 IL2 IL6 LTA TNF
35 11.57 IL6 LTA TNF
36 11.54 CXCL8 IL6 TNF
37 11.46 CXCL8 IL6 TNF
38 11.44 C1S CXCL8 IL6 TNF
39 11.43 CXCL8 IL6
40
Show member pathways
11.42 LTA TNF
41 11.42 IL2 IL6 TNF
42 11.4 IL6 TNF
43 11.4 IL2 TNF
44 11.39 CXCL8 IL6 TNF
45 11.38 CXCL8 IL6 TNF
46 11.37 IL6 TNF
47
Show member pathways
11.27 IL2 TNF
48 11.26 IL6 TNF
49
Show member pathways
11.26 CXCL8 IL2 IL6 TNF
50 11.25 IL6 TNF

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CXCL8 IL2 IL6 LTA TNF
2 extracellular region GO:0005576 9.1 C1S CXCL8 IL2 IL6 LTA TNF

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.63 CXCL8 IL6 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.58 IL6 LTA TNF
3 negative regulation of fat cell differentiation GO:0045599 9.55 IL6 TNF
4 positive regulation of interleukin-6 production GO:0032755 9.54 IL6 TNF
5 positive regulation of chemokine production GO:0032722 9.52 IL6 TNF
6 embryonic digestive tract development GO:0048566 9.51 CXCL8 TNF
7 humoral immune response GO:0006959 9.5 IL6 LTA TNF
8 negative regulation of growth of symbiont in host GO:0044130 9.49 LTA TNF
9 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL2 IL6
10 negative regulation of lipid storage GO:0010888 9.43 IL6 TNF
11 positive regulation of interferon-gamma production GO:0032729 9.43 IL2 LTA TNF
12 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.37 LTA TNF
13 immune response GO:0006955 9.35 CXCL8 IL2 IL6 LTA TNF
14 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
15 regulation of receptor activity GO:0010469 9.02 CXCL8 IL2 IL6 LTA TNF

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL2 IL6 LTA TNF
2 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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