MCID: STR077
MIFTS: 44

Streptococcal Toxic-Shock Syndrome malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 51
Streptococcal Toxic Shock Syndrome 65
 
Streptococcal Tss 51

Classifications:



External Ids:

Orphanet51 99918
ICD10 via Orphanet28 A48.3
UMLS via Orphanet66 C0343532
UMLS65 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

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MalaCards based summary: Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to toxic shock syndrome and fasciitis, and has symptoms including presyncope, syncope and dizziness. An important gene associated with Streptococcal Toxic-Shock Syndrome is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and ATF-2 transcription factor network. Affiliated tissues include t cells, liver and colon.

Related Diseases for Streptococcal Toxic-Shock Syndrome

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Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1toxic shock syndrome11.4
2fasciitis10.5
3necrotizing fasciitis10.4
4corneal abscess10.4CXCL8, IL6
5neonatal period electroclinical syndrome10.4CXCL8, IL6
6osteogenesis imperfecta, type x10.4CXCL8, IL6
7optic neuritis10.4CXCL8, IL6
8eyelid neoplasm10.4CXCL8, IL6
9narcissistic personality disorder10.4CXCL8, IL6
10scrotum squamous cell carcinoma10.4CXCL8, IL6
11blue toe syndrome10.4CXCL8, IL6
12endocarditis10.4CXCL8, IL6
13aggressive digital papillary adenocarcinoma10.4CXCL8, IL6
14alcoholic gastritis10.4CXCL8, IL6
15psychologic dyspareunia10.4CXCL8, IL6
16cutaneous paget's disease10.4CXCL8, IL6
17hidrocystoma10.4CXCL8, IL6
18adult t-cell leukemia10.3CXCL8, IL6
19retinitis pigmentosa10.3CXCL8, IL6
20xanthogranulomatous pyelonephritis10.3CXCL8, IL6
21adult spinal cord glioblastoma multiforme10.3CXCL8, IL6
22childhood kidney angiomyolipoma10.3CXCL8, IL6
23arthritis10.3
24fat necrosis of breast10.3CXCL8, IL6
25retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities10.3CXCL8, IL6
26peritonitis10.3
27toxic myocarditis10.2IL6, LTA
28rheumatoid arthritis10.2
29postmenopausal atrophic vaginitis10.2CXCL8, IL6
30viral gastritis10.2CXCL8, IL6
31hair defect with photosensitivity and mental retardation10.2CXCL8, TNF
32disease of mental health10.1CXCL8, IL6
33tuberculous uveitis10.1CXCL8, TNF
34testicular granulosa cell tumor10.1CXCL8, TNF
35occipital lobe neoplasm10.1CXCL8, TNF
36henoch-schoenlein purpura10.1CXCL8, TNF
37auricular cancer10.1CXCL8, TNF
38chronic tic disorder10.1CXCL8, TNF
39peripheral retinal degeneration10.1CXCL8, TNF
40gastritis10.1
41myositis10.1
42scarlet fever10.1
43pustulosis palmaris et plantaris10.1CXCL8, TNF
44intermediate dend syndrome10.1IL6, TNF
45crohn's disease10.1IL6, TNF
46postcholecystectomy syndrome10.0CXCL8, TNF
47mammary paget's disease10.0IL6, TNF
48lujo hemorrhagic fever10.0IL6, TNF
49critical illness polyneuropathy10.0C1S, CXCL8, IL6
50posterior valve urethra10.0IL6, TNF

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to streptococcal toxic-shock syndrome

Symptoms for Streptococcal Toxic-Shock Syndrome

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UMLS symptoms related to Streptococcal Toxic-Shock Syndrome:


presyncope, syncope, dizziness

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

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Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 24477
2Rho(D) Immune GlobulinPhase 2206
3Immunologic FactorsPhase 218483
4Pharmaceutical SolutionsPhase 27004
5Immunoglobulins, IntravenousPhase 2211
6ImmunoglobulinsPhase 24477
7methicillin148
8Anti-Infective Agents17220
9Vaccines6085
10Anti-Bacterial Agents9140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot StudyRecruitingNCT02219165Phase 2
2Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital TractCompletedNCT00299663
3Surveillance of Streptococcal Infections in Children in IndiaCompletedNCT00342199
4Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus AureusCompletedNCT01141101
5Severe Soft Tissue Infections: Perspectives of Patients and Significant OthersRecruitingNCT02169128

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

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Anatomical Context for Streptococcal Toxic-Shock Syndrome

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MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

33
T cells, Liver, Colon, Heart, Skin, Monocytes, Spinal cord

Animal Models for Streptococcal Toxic-Shock Syndrome or affiliated genes

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Publications for Streptococcal Toxic-Shock Syndrome

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Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50)    (show all 171)
idTitleAuthorsYear
1
Profuse watery diarrhoea: An unusual presenting feature of streptococcal toxic shock syndrome. (27124845)
2016
2
Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. (26025992)
2015
3
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012. (25703404)
2015
4
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. (25260866)
2014
5
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome. (25313253)
2014
6
Treatment of postoperative purulent pericarditis and streptococcal toxic shock syndrome by intensive blood purification. (25228196)
2014
7
Streptococcal toxic shock syndrome following total thyroidectomy. (24112488)
2013
8
Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. (21460306)
2011
9
Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates. (20368967)
2010
10
Phlegmonous gastritis and group A streptococcal toxic shock syndrome in a patient following functional endoscopic sinus surgery. (20575666)
2010
11
Necrotizing fascitis and streptococcal toxic shock syndrome complicating herpes zoster: a vaccine talking point? (21246167)
2009
12
Intravenous immunoglobulin in children with streptococcal toxic shock syndrome. (19788359)
2009
13
Streptococcal toxic shock syndrome following insertion of an intrauterine device--a case report. (19916766)
2009
14
Puerperal streptococcal toxic shock syndrome treated with recombinant human activated protein C and intravenous immunoglobulin. (19195874)
2009
15
Bacterial phenotype variants in group B streptococcal toxic shock syndrome. (19193266)
2009
16
A fatal case of streptococcal toxic shock syndrome. (18453517)
2008
17
Fatal streptococcal toxic shock syndrome in a child with varicella and necrotizing fasciitis of the face. (19078822)
2008
18
Puerperal widespread pyomyositis after group A streptococcal toxic shock syndrome. (18669156)
2008
19
Spontaneous perforation of the cystic duct in streptococcal toxic shock syndrome: a case report. (18959771)
2008
20
Bullous impetigo: a rare presentation in fulminant streptococcal toxic shock syndrome. (17505275)
2007
21
A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. (17375201)
2007
22
Sudden unexpected death in a child with varicella caused by necrotizing fasciitis and streptococcal toxic shock syndrome. (16501360)
2006
23
Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome. (16912949)
2006
24
Streptococcal toxic shock syndrome with initial manifestation of abdominal pain and cholecystitis. (16302590)
2005
25
Fatal streptococcal toxic shock syndrome in a patient with rheumatoid arthritis treated with etanercept. (15870144)
2005
26
Diffuse venous thromboemboli associated with IVIg therapy in the treatment of streptococcal toxic shock syndrome: case report and review. (15815906)
2005
27
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
28
Streptococcal toxic shock syndrome presenting with spontaneous hypoglycemia in a chronic hemodialysis patient: pathophysiological mechanisms. (12793713)
2003
29
Streptococcal toxic shock syndrome manifesting as peritonitis in a child. (12353345)
2002
30
Group A streptococcal toxic shock syndrome developing in the third trimester of pregnancy. (12648315)
2002
31
Streptococcal toxic shock syndrome: a description of 14 cases from North Yorkshire, UK. (12010172)
2002
32
Streptococcal toxic shock syndrome. (12010167)
2002
33
A family cluster of streptococcal toxic shock syndrome in children: clinical implication and epidemiological investigation. (11331706)
2001
34
Kallikrein-kinin system activation in streptococcal toxic shock syndrome. (10880316)
2000
35
Human bite on penile shaft from oral sex as a portal of entry for streptococcal toxic shock syndrome. (11344784)
2000
36
Intravenous immunoglobulin as adjunctive treatment for streptococcal toxic shock syndrome associated with necrotizing fasciitis: case report and review. (10610017)
1999
37
Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome--a comparative observational study. The Canadian Streptococcal Study Group. (10825042)
1999
38
Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome. (9868656)
1998
39
Rationale for the use of intravenous gamma globulin in the treatment of streptococcal toxic shock syndrome. (9524836)
1998
40
Update on canine streptococcal toxic shock syndrome and necrotizing fasciitis. (9105725)
1997
41
Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates. (9393817)
1997
42
Acute group G streptococcal myositis associated with streptococcal toxic shock syndrome: case report and review. (8922817)
1996
43
Streptococcal toxic shock syndrome in a postpartum woman. Case report and review of the literature. (8740114)
1996
44
Detection of circulating bacterial superantigen and lymphotoxin-alpha in patients with streptococcal toxic-shock syndrome. (8909404)
1996
45
Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. (8903167)
1995
46
Clinical and microbiological characteristics of severe group A streptococcus infections and streptococcal toxic shock syndrome. (8562741)
1995
47
Case report: streptococcal toxic shock syndrome presenting as septic thrombophlebitis in a child with varicella. (8108215)
1993
48
Streptococcal toxic shock syndrome in children. (1644967)
1992
49
Pediatric streptococcal toxic shock syndrome. (1513730)
1992
50
Streptococcal toxic shock syndrome due to noninvasive pharyngitis. (1600009)
1992

Variations for Streptococcal Toxic-Shock Syndrome

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Expression for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathwaysScoreTop Affiliating Genes
19.5CXCL8, IL6
29.5CXCL8, IL6
39.5CXCL8, IL6
49.5CXCL8, IL6
59.2CXCL8, TNF
69.1IL6, TNF
79.1IL6, TNF
89.1IL6, TNF
99.1IL6, TNF
109.1IL6, TNF
11
Show member pathways
9.0LTA, TNF
129.0LTA, TNF
13
Show member pathways
8.7CXCL8, IL6, TNF
14
Show member pathways
8.7CXCL8, IL6, TNF
15
Show member pathways
8.7CXCL8, IL6, TNF
16
Show member pathways
8.7CXCL8, IL6, TNF
178.7CXCL8, IL6, TNF
188.7CXCL8, IL6, TNF
198.7CXCL8, IL6, TNF
208.7CXCL8, IL6, TNF
218.7CXCL8, IL6, TNF
228.7CXCL8, IL6, TNF
238.7CXCL8, IL6, TNF
24
Show member pathways
8.7CXCL8, IL6, TNF
258.7CXCL8, IL6, TNF
268.6CXCL8, LTA, TNF
27
Show member pathways
8.5IL6, LTA, TNF
28
Show member pathways
8.5IL6, LTA, TNF
298.5IL6, LTA, TNF
308.5IL6, LTA, TNF
318.5IL6, LTA, TNF
328.3C1S, CXCL8, IL6, TNF
33
Show member pathways
8.1CXCL8, IL6, LTA, TNF
34
Show member pathways
8.1CXCL8, IL6, LTA, TNF
35
Show member pathways
8.1CXCL8, IL6, LTA, TNF

GO Terms for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.8IL6, TNF
2positive regulation of nitric oxide biosynthetic processGO:00454299.7IL6, TNF
3embryonic digestive tract developmentGO:00485669.7CXCL8, TNF
4positive regulation of chronic inflammatory response to antigenic stimulusGO:00028769.6LTA, TNF
5negative regulation of lipid storageGO:00108889.6IL6, TNF
6negative regulation of fat cell differentiationGO:00455999.5IL6, TNF
7response to glucocorticoidGO:00513849.5IL6, TNF
8positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL6, TNF
9positive regulation of peptidyl-serine phosphorylationGO:00331389.4IL6, TNF
10positive regulation of protein kinase B signalingGO:00518979.4IL6, TNF
11positive regulation of interferon-gamma productionGO:00327299.4LTA, TNF
12positive regulation of smooth muscle cell proliferationGO:00486619.4IL6, TNF
13positive regulation of interleukin-6 productionGO:00327559.2IL6, TNF
14defense response to Gram-positive bacteriumGO:00508309.0IL6, LTA, TNF
15cellular response to lipopolysaccharideGO:00712228.7CXCL8, IL6, TNF
16positive regulation of apoptotic processGO:00430658.5IL6, LTA, TNF
17immune responseGO:00069558.4CXCL8, IL6, TNF

Sources for Streptococcal Toxic-Shock Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet