MCID: STR077
MIFTS: 42

Streptococcal Toxic-Shock Syndrome malady

Infectious category

Summaries for Streptococcal Toxic-Shock Syndrome

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33MalaCards
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MalaCards: Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to toxic shock syndrome and arthritis. An important gene associated with Streptococcal Toxic-Shock Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are Rho Family GTPases and PAK Pathway. The compounds pentoxifylline and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and breast.

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

streptococcal toxic-shock syndrome 49
streptococcal toxic shock syndrome 61
streptococcal tss 49


External Ids:

ICD10 via Orphanet26 A48.3
SNOMED-CT via Orphanet58 240451000
UMLS via Orphanet62 C0343532

Related Diseases for Streptococcal Toxic-Shock Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to streptococcal toxic-shock syndrome

Clinical Features for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Streptococcal Toxic-Shock Syndrome

Drug clinical trials:

Search ClinicalTrials for Streptococcal Toxic-Shock Syndrome

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Search CenterWatch for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

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33MalaCards
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MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

33
Skin, Colon, Breast, Monocytes, T cells, B cells

Animal Models for Streptococcal Toxic-Shock Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Streptococcal Toxic-Shock Syndrome

Sources:
51PubMed
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Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50)    (show all 180)
idTitleAuthorsYear
1
Streptococcal toxic shock syndrome following total thyroidectomy. (24112488)
2013
2
Fatal streptococcal toxic shock syndrome from an intrauterine device. (23394954)
2013
3
Streptococcal Toxic Shock Syndrome. (24297338)
2013
4
Palpable purpura complicated by streptococcal toxic shock syndrome resulting in limb necrosis and amputation: a case of levamisole and cocaine coingestion. (22392427)
2012
5
A case of streptococcal toxic shock syndrome due to Group G streptococci identified as Streptococcus dysgalactiae subsp. equisimilis. (22327489)
2012
6
Clinical characteristics of children with group A streptococcal toxic shock syndrome admitted to pediatric intensive care units. (20981441)
2011
7
Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome. (21673039)
2011
8
Group A streptococcal toxic shock syndrome from a traumatic myositis. (20657633)
2010
9
Intrauterine fetal demise due to streptococcal toxic shock syndrome: a case report. (21077531)
2010
10
Necrotizing fascitis and streptococcal toxic shock syndrome complicating herpes zoster: a vaccine talking point? (21246167)
2009
11
Puerperal streptococcal toxic shock syndrome treated with recombinant human activated protein C and intravenous immunoglobulin. (19195874)
2009
12
Bacterial phenotype variants in group B streptococcal toxic shock syndrome. (19193266)
2009
13
Inactivation of dipeptidyl peptidase IV attenuates the virulence of Streptococcus suis serotype 2 that causes streptococcal toxic shock syndrome. (19484301)
2009
14
Prolonged varicella viraemia and streptococcal toxic shock syndrome following varicella vaccination of a health care worker. (19374621)
2009
15
Streptococcal toxic shock syndrome presenting as septic knee arthritis in a 5-year-old child. (18157057)
2008
16
Onset of streptococcal toxic shock syndrome is accelerated by bruising in a mouse model. (18061395)
2008
17
Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome. (16912949)
2006
18
Group A streptococcal toxic shock syndrome after an office endometrial biopsy: a case report. (16967640)
2006
19
Fatal streptococcal toxic shock syndrome in a patient with rheumatoid arthritis treated with etanercept. (15870144)
2005
20
Streptococcal toxic shock syndrome in children without skin and soft tissue infection: report of four cases. (16188783)
2005
21
The molecular basis of streptococcal toxic shock syndrome. (15141050)
2004
22
Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. (12884156)
2003
23
A new therapeutic strategy for streptococcal toxic shock syndrome: a key target for cytokines. (12636246)
2003
24
Nonsteroidal anti-inflammatory drugs and streptococcal toxic shock syndrome. (12400522)
2002
25
A family cluster of streptococcal toxic shock syndrome in children: clinical implication and epidemiological investigation. (11331706)
2001
26
Kallikrein-kinin system activation in streptococcal toxic shock syndrome. (10880316)
2000
27
Molecular epidemiology of nga and NAD glycohydrolase/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome. (10979908)
2000
28
Streptococcal toxic shock syndrome: a physician tells the story of her survival. (10880301)
2000
29
Invasive group A streptococcus infection of the scrotum and streptococcal toxic shock syndrome. (11018632)
2000
30
Toxoids of streptococcal pyrogenic exotoxin A are protective in rabbit models of streptococcal toxic shock syndrome. (10948118)
2000
31
Therapeutic Approaches to Streptococcal Toxic Shock Syndrome. (11095793)
1999
32
Relatedness of Streptococcus canis from canine streptococcal toxic shock syndrome and necrotizing fasciitis. (10369564)
1999
33
Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome. (9868656)
1998
34
Rationale for the use of intravenous gamma globulin in the treatment of streptococcal toxic shock syndrome. (9524836)
1998
35
Toxic shock syndrome in association with group-A streptococcal infection of a knee joint after a total knee arthroplasty: a case report. (9469314)
1998
36
Streptococcal pyrogenic exotoxin A, streptolysin O, exoenzymes, serotype and biotype profiles of Streptococcus pyogenes isolates from patients with toxic shock syndrome and other severe infections. (9361388)
1997
37
Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates. (9393817)
1997
38
Superantigenic activity produced by group A streptococcal isolates is neutralized by plasma from IVIG-treated streptococcal toxic shock syndrome patients. (9331714)
1997
39
Microbial factors in disease emergence illustrated by streptococcal toxic shock syndrome. (9348157)
1997
40
Adjunctive treatment of streptococcal toxic shock syndrome using intravenous immunoglobulin: case report and review. (9209207)
1997
41
Successful treatment of severe streptococcal toxic shock syndrome with a combination of intravenous immunoglobulin, dexamethasone and antibiotics. (9039540)
1997
42
Streptococcal toxic shock syndrome from a puncture wound to the foot. (8986898)
1996
43
Necrotizing group A streptococcal infections associated with streptococcal toxic shock syndrome. (8942557)
1996
44
Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. (8903167)
1995
45
Streptococcal toxic shock syndrome: report of two cases. (7496075)
1995
46
CDC defines group A streptococcal toxic shock syndrome. (8389092)
1993
47
Streptococcal toxic shock syndrome in children. (1644967)
1992
48
Pediatric streptococcal toxic shock syndrome. (1513730)
1992
49
Resurgence of virulent group A streptococcal infections - the streptococcal toxic shock syndrome. (22416194)
1992
50
Streptococcal toxic shock syndrome. (2184817)
1990

Genetic Variations for Streptococcal Toxic-Shock Syndrome

Expression for genes affiliated with Streptococcal Toxic-Shock Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for genes affiliated with Streptococcal Toxic-Shock Syndrome

Sources:
52QIAGEN, 54Reactome, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore
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Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1LTA
2
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10.1LTA
3
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10.1LTA
4
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10.0IL8
510.0IL8
69.5IL8, KNG1
79.5IL8, IL1B
89.4TNF, IL1B
99.4TNF, IL1B
109.3IL8, TNF
119.2IL6, IL1B
129.1IL6, IL8
139.1IL6, IL8
14
Hide members
9.0TNF, LTA, IL1B
15
Hide members
9.0TNF, LTA, IL1B
16
Hide members
8.8IL6, IL1B, LTA
178.7IL1B, IL6, IL8
188.7IL6, IL1B, IL8
19
Hide members
8.7IL6, LTA, TNF
20
Hide members
8.7TNF, LTA, IL6
218.6KNG1, IL6, TNF
228.6IL1B, IL6, TNF
238.6IL6, IL1B, TNF
24
Development PDGF signaling via STATs and NF-kB
Hide members
8.6IL1B, IL6, TNF
258.6IL6, IL1B, TNF
268.6IL1B, IL6, TNF
278.6IL1B, TNF, IL6
288.6IL1B, TNF, IL6
298.5TNF, IL6, IL8
308.5IL8, TNF, IL1B, LTA
318.2IL1B, LTA, TNF, IL6
32
Hide members
8.2IL6, IL1B, LTA, TNF
33
Hide members
8.2IL6, IL1B, LTA, TNF
34
Hide members
8.2IL6, LTA, IL1B, TNF
35
Hide members
8.1TNF, IL8, IL1B, IL6
368.1TNF, IL8, IL6, IL1B
37
Immune response Bacterial infections in normal airways
Hide members
8.1TNF, IL8, IL1B, IL6
38
Hide members
8.1IL1B, IL8, TNF, IL6
39
Hide members
8.1IL1B, IL6, IL8, TNF
408.1TNF, IL6, IL1B, IL8
41
Hide members
8.1IL1B, TNF, IL6, IL8
427.7C1S, TNF, IL8, IL1B, IL6
437.7IL8, IL6, IL1B, LTA, TNF
44
Hide members
7.7IL6, IL1B, IL8, LTA, TNF
45
Hide members
7.7LTA, IL6, TNF, IL1B, IL8

Compounds for genes affiliated with Streptococcal Toxic-Shock Syndrome

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 50PharmGKB, 24HMDB
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Compounds related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.5LTA
2cycloheximide4510.5LTA
3indomethacin45 60 29 1113.4KNG1
4gm-csf45 2911.3TNF
5hydrocortisone45 2 60 1113.2IL8
6aprotinin45 1110.9C1S, IL8
7flurbiprofen45 29 50 1112.4KNG1, LTA, IL1B
8gold sodium thiomalate459.2IL1B, TNF, IL8
95 aminosalicylic acid459.1IL8, IL1B, TNF
10staurosporin459.0TNF, IL8, IL1B
11hbd2459.0IL6, IL1B, IL8
12toxin-1458.9IL1B, IL8, LTA, TNF
13anakinra45 119.9IL1B, IL6, TNF
14adalimumab45 50 1110.9IL6, TNF, C1S
15vesnarinone458.9IL6, IL1B, TNF
16okt3458.7TNF, IL6, LTA
17infliximab45 50 1110.6TNF, IL6, IL1B, LTA
18imiquimod45 29 60 1111.6IL6, IL8, TNF
19rantes458.6TNF, LTA, IL6, IL1B
20prostacyclin458.5IL1B, TNF, C1S, KNG1
21taurine chloramine458.5IL6, IL1B, IL8, TNF
22mip 1alpha458.5IL6, IL1B, TNF, IL8
23il-12458.5TNF, IL8, IL1B, IL6
24tpck458.5IL8, IL1B, IL6, TNF
25polymyxin b458.5IL6, IL8, TNF, IL1B
26groalpha458.5IL6, IL8, TNF, IL1B
27triptolide458.5IL6, TNF, IL8, IL1B
28ciglitazone45 299.5IL6, IL8, TNF, IL1B
29polyinosinic-polycytidylic acid458.4IL8, TNF, IL6, IL1B
30poly(i-c)458.4IL1B, TNF, IL8, IL6
31peptidoglycan45 299.4TNF, IL8, IL1B, IL6
32ccl345 299.4IL1B, IL6, TNF, IL8
3315-deoxy-delta-12,14-prostaglandin j2458.4TNF, IL8, IL1B, IL6
34pdtc458.4IL8, IL1B, TNF, IL6
35tgf beta1458.4TNF, LTA, IL6, IL1B
36sp 60012545 609.3IL8, TNF, IL1B, IL6
37troglitazone45 29 60 1111.3IL6, IL1B, TNF, IL8
38hyaluronic acid45 249.2LTA, IL8, MYOM2, IL6, IL1B
39lipoteichoic acid458.1TNF, LTA, IL8, IL1B, IL6
40il 10458.1TNF, IL8, IL6, IL1B, LTA
41neopterin458.1IL6, IL1B, IL8, TNF, LTA
42herbimycin a45 609.1IL8, IL1B, IL6, TNF, LTA
43leukotriene b445 60 2410.1TNF, KNG1, IL6, IL1B, IL8
44curcumin458.1TNF, IL8, IL1B, IL6
45histamine45 29 2410.0IL6, IL1B, IL8, KNG1, TNF
46genistein45 29 60 2 11 2412.9IL6, IL8, TNF, KNG1, IL1B
47prostaglandin457.9TNF, IL6, IL1B, KNG1
48etanercept45 50 119.8IL6, IL1B, LTA, C1S, IL8, TNF
49actinomycin d457.7LTA, IL8, KNG1, TNF, IL1B, IL6
50nitric oxide45 11 249.3IL6, TNF, KNG1, C1S, LTA, IL8

GO Terms for genes affiliated with Streptococcal Toxic-Shock Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3C1S, TNF, KNG1, IL8, IL1B, IL6
2extracellular spaceGO:0056157.0TNF, KNG1, LTA, IL8, IL1B, IL6

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.9LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.8TNF, LTA
3sequestering of triglycerideGO:0307309.8IL1B, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IL1B
5positive regulation of heterotypic cell-cell adhesionGO:0341169.8TNF, IL1B
6positive regulation of fever generationGO:0316229.8IL1B, TNF
7negative regulation of growth of symbiont in hostGO:0441309.7TNF, LTA
8positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IL1B
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7TNF, IL1B
10positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IL1B, TNF
11negative regulation of lipid catabolic processGO:0509959.7TNF, IL1B
12positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL1B
13negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
14embryonic digestive tract developmentGO:0485669.6TNF, IL8
15positive regulation of mitosisGO:0458409.6TNF, IL1B
16lipopolysaccharide-mediated signaling pathwayGO:0316639.5TNF, IL1B
17cellular response to organic cyclic compoundGO:0714079.5TNF, IL1B
18protein kinase B signaling cascadeGO:0434919.5TNF, IL1B
19positive regulation of interferon-gamma productionGO:0327299.4TNF, IL1B, LTA
20epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.4TNF, IL6
21negative regulation of lipid storageGO:0108889.4TNF, IL6
22positive regulation of chemokine productionGO:0327229.3IL6, TNF
23neutrophil chemotaxisGO:0305939.2IL8, IL1B
24defense response to Gram-positive bacteriumGO:0508309.1TNF, LTA, IL6
25humoral immune responseGO:0069599.0TNF, LTA, IL6
26negative regulation of fat cell differentiationGO:0455999.0IL6, TNF
27positive regulation of smooth muscle cell proliferationGO:0486619.0IL6, TNF
28positive regulation of nitric oxide biosynthetic processGO:0454299.0IL1B, TNF, IL6
29positive regulation of interleukin-6 productionGO:0327559.0IL6, IL1B, TNF
30positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL6, IL1B, TNF
31positive regulation of NF-kappaB transcription factor activityGO:0510928.9TNF, IL6, IL1B
32positive regulation of apoptotic processGO:0430658.6TNF, IL6, LTA, KNG1
33response to drugGO:0424938.6IL6, TNF, LTA
34negative regulation of cell proliferationGO:0082858.4IL1B, IL6, IL8, TNF
35inflammatory responseGO:0069548.1IL1B, TNF, KNG1, IL6, IL8

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5LTA, TNF
2cytokine activityGO:0051257.9IL6, IL1B, LTA, TNF

Products for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Sources for Streptococcal Toxic-Shock Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet