MCID: STR077
MIFTS: 34

Streptococcal Toxic-Shock Syndrome malady

Infectious diseases category

Summaries for Streptococcal Toxic-Shock Syndrome

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MalaCards: Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to toxic shock syndrome and arthritis. An important gene associated with Streptococcal Toxic-Shock Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are Rho Family GTPases and PAK Pathway. The compounds pentoxifylline and cycloheximide have been mentioned in the context of this disorder.

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

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48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

streptococcal toxic-shock syndrome 48
streptococcal toxic shock syndrome 60
streptococcal tss 48


External Ids:

ICD10 via Orphanet26 A48.3
SNOMED-CT via Orphanet57 240451000
UMLS via Orphanet61 C0343532

Related Diseases for Streptococcal Toxic-Shock Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to streptococcal toxic-shock syndrome

Clinical Features for Streptococcal Toxic-Shock Syndrome

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Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Streptococcal Toxic-Shock Syndrome

Drug clinical trials:

Search ClinicalTrials for Streptococcal Toxic-Shock Syndrome

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Search CenterWatch for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

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Anatomical Context for Streptococcal Toxic-Shock Syndrome

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Animal Models for Streptococcal Toxic-Shock Syndrome or affiliated genes

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Publications for Streptococcal Toxic-Shock Syndrome

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Genetic Variations for Streptococcal Toxic-Shock Syndrome

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Expression for genes affiliated with Streptococcal Toxic-Shock Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for genes affiliated with Streptococcal Toxic-Shock Syndrome

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51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
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Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1LTA
2
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10.1LTA
3
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10.1LTA
4
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10.0IL8
510.0IL8
69.5IL8, KNG1
79.5IL8, IL1B
89.4TNF, IL1B
99.4TNF, IL1B
109.3IL8, TNF
119.2IL6, IL1B
129.1IL6, IL8
139.1IL6, IL8
14
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9.0TNF, LTA, IL1B
15
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9.0TNF, LTA, IL1B
16
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8.8IL6, IL1B, LTA
178.7IL1B, IL6, IL8
188.7IL6, IL1B, IL8
19
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8.7IL6, LTA, TNF
20
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8.7TNF, LTA, IL6
218.6KNG1, IL6, TNF
228.6IL1B, IL6, TNF
238.6IL6, IL1B, TNF
24
Development PDGF signaling via STATs and NF-kB
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8.6IL1B, IL6, TNF
258.6IL6, IL1B, TNF
268.6IL1B, IL6, TNF
278.6IL1B, TNF, IL6
288.6IL1B, TNF, IL6
298.5TNF, IL6, IL8
308.5IL8, TNF, IL1B, LTA
318.2IL1B, LTA, TNF, IL6
32
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8.2IL6, IL1B, LTA, TNF
33
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8.2IL6, IL1B, LTA, TNF
34
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8.2IL6, LTA, IL1B, TNF
35
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8.1TNF, IL8, IL1B, IL6
368.1TNF, IL8, IL6, IL1B
37
Immune response Bacterial infections in normal airways
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8.1TNF, IL8, IL1B, IL6
38
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8.1IL1B, IL8, TNF, IL6
39
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8.1IL1B, IL6, IL8, TNF
408.1TNF, IL6, IL1B, IL8
41
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8.1IL1B, TNF, IL6, IL8
427.7C1S, TNF, IL8, IL1B, IL6
437.7IL8, IL6, IL1B, LTA, TNF
44
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7.7IL6, IL1B, IL8, LTA, TNF
45
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7.7LTA, IL6, TNF, IL1B, IL8

Compounds for genes affiliated with Streptococcal Toxic-Shock Syndrome

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.5LTA
2cycloheximide4410.5LTA
3indomethacin44 59 28 1113.4KNG1
4gm-csf44 2811.3TNF
5hydrocortisone44 2 59 1113.2IL8
6aprotinin44 1110.9IL8, C1S
7flurbiprofen44 28 49 1112.4KNG1, LTA, IL1B
8gold sodium thiomalate449.2TNF, IL8, IL1B
95 aminosalicylic acid449.1TNF, IL8, IL1B
10staurosporin449.0IL1B, IL8, TNF
11hbd2449.0IL6, IL1B, IL8
12toxin-1448.9IL1B, IL8, LTA, TNF
13anakinra44 119.9TNF, IL1B, IL6
14adalimumab44 49 1110.9IL6, TNF, C1S
15vesnarinone448.9TNF, IL1B, IL6
16okt3448.7IL6, LTA, TNF
17infliximab44 49 1110.6TNF, LTA, IL1B, IL6
18imiquimod44 28 59 1111.6TNF, IL8, IL6
19rantes448.6IL6, IL1B, LTA, TNF
20prostacyclin448.5IL1B, KNG1, TNF, C1S
21taurine chloramine448.5IL6, IL1B, IL8, TNF
22mip 1alpha448.5TNF, IL8, IL1B, IL6
23il-12448.5IL6, IL1B, IL8, TNF
24tpck448.5TNF, IL8, IL1B, IL6
25polymyxin b448.5TNF, IL8, IL1B, IL6
26groalpha448.5IL6, IL1B, IL8, TNF
27triptolide448.5TNF, IL8, IL1B, IL6
28ciglitazone44 289.5IL6, IL1B, IL8, TNF
29polyinosinic-polycytidylic acid448.4IL6, IL1B, IL8, TNF
30poly(i-c)448.4TNF, IL8, IL1B, IL6
31peptidoglycan44 289.4IL6, IL1B, IL8, TNF
32ccl344 289.4TNF, IL8, IL1B, IL6
3315-deoxy-delta-12,14-prostaglandin j2448.4TNF, IL8, IL1B, IL6
34pdtc448.4IL6, IL1B, IL8, TNF
35tgf beta1448.4TNF, LTA, IL1B, IL6
36sp 60012544 599.3TNF, IL8, IL1B, IL6
37troglitazone44 28 59 1111.3TNF, IL8, IL1B, IL6
38hyaluronic acid44 249.2MYOM2, LTA, IL8, IL1B, IL6
39lipoteichoic acid448.1TNF, LTA, IL8, IL1B, IL6
40il 10448.1TNF, LTA, IL8, IL1B, IL6
41neopterin448.1TNF, LTA, IL8, IL1B, IL6
42herbimycin a44 599.1TNF, LTA, IL8, IL1B, IL6
43leukotriene b444 59 2410.1TNF, KNG1, IL8, IL1B, IL6
44curcumin448.1TNF, IL8, IL1B, IL6
45histamine44 28 2410.0TNF, KNG1, IL8, IL1B, IL6
46genistein44 28 59 2 11 2412.9TNF, KNG1, IL8, IL1B, IL6
47prostaglandin447.9TNF, KNG1, IL1B, IL6
48etanercept44 49 119.8IL6, IL1B, IL8, LTA, TNF, C1S
49actinomycin d447.7TNF, KNG1, LTA, IL8, IL1B, IL6
50nitric oxide44 11 249.3C1S, TNF, KNG1, LTA, IL8, IL1B

GO Terms for genes affiliated with Streptococcal Toxic-Shock Syndrome

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16Gene Ontology
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Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.3C1S, TNF, KNG1, IL8, IL1B, IL6
2extracellular spaceGO:0056157.0TNF, KNG1, LTA, IL8, IL1B, IL6

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.9LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.8TNF, LTA
3sequestering of triglycerideGO:0307309.8IL1B, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IL1B
5positive regulation of heterotypic cell-cell adhesionGO:0341169.8TNF, IL1B
6positive regulation of fever generationGO:0316229.8IL1B, TNF
7negative regulation of growth of symbiont in hostGO:0441309.7TNF, LTA
8positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IL1B
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7TNF, IL1B
10positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IL1B, TNF
11negative regulation of lipid catabolic processGO:0509959.7TNF, IL1B
12positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL1B
13negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1B, TNF
14embryonic digestive tract developmentGO:0485669.6TNF, IL8
15positive regulation of mitosisGO:0458409.6TNF, IL1B
16lipopolysaccharide-mediated signaling pathwayGO:0316639.5TNF, IL1B
17cellular response to organic cyclic compoundGO:0714079.5TNF, IL1B
18protein kinase B signaling cascadeGO:0434919.5TNF, IL1B
19positive regulation of interferon-gamma productionGO:0327299.4TNF, IL1B, LTA
20epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.4TNF, IL6
21negative regulation of lipid storageGO:0108889.4TNF, IL6
22positive regulation of chemokine productionGO:0327229.3IL6, TNF
23neutrophil chemotaxisGO:0305939.2IL8, IL1B
24defense response to Gram-positive bacteriumGO:0508309.1TNF, LTA, IL6
25humoral immune responseGO:0069599.0TNF, LTA, IL6
26negative regulation of fat cell differentiationGO:0455999.0IL6, TNF
27positive regulation of smooth muscle cell proliferationGO:0486619.0IL6, TNF
28positive regulation of nitric oxide biosynthetic processGO:0454299.0IL1B, TNF, IL6
29positive regulation of interleukin-6 productionGO:0327559.0IL6, IL1B, TNF
30positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL6, IL1B, TNF
31positive regulation of NF-kappaB transcription factor activityGO:0510928.9TNF, IL6, IL1B
32positive regulation of apoptotic processGO:0430658.6TNF, IL6, LTA, KNG1
33response to drugGO:0424938.6IL6, TNF, LTA
34negative regulation of cell proliferationGO:0082858.4IL1B, IL6, IL8, TNF
35inflammatory responseGO:0069548.1IL1B, TNF, KNG1, IL6, IL8

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5LTA, TNF
2cytokine activityGO:0051257.9IL6, IL1B, LTA, TNF

Products for genes affiliated with Streptococcal Toxic-Shock Syndrome

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Sources for Streptococcal Toxic-Shock Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet