MCID: STR077
MIFTS: 39

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 56
Streptococcal Toxic Shock Syndrome 69
Streptococcal Tss 56

Characteristics:

Orphanet epidemiological data:

56
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Orphanet 56 ORPHA99918
UMLS via Orphanet 70 C0343532
ICD10 via Orphanet 34 A48.3

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to rheumatoid arthritis and staphylococcal toxic shock syndrome. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Rifampin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and skin.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.4 CXCL8 IL2 IL6 TNF
2 staphylococcal toxic shock syndrome 11.3
3 toxic shock syndrome 11.0
4 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
5 aortic arch interruption 10.6 IL6 TNF
6 cutaneous leishmaniasis 10.6 IL6 TNF
7 dyslexia 5 10.6 IL6 TNF
8 epstein-barr virus hepatitis 10.6 IL6 TNF
9 scrotal carcinoma 10.6 IL6 TNF
10 anencephaly and spina bifida x-linked 10.6 IL6 TNF
11 antigen-peptide-transporter 2 deficiency 10.6 IL6 TNF
12 papilledema 10.6 IL6 TNF
13 ethmoid sinus adenocarcinoma 10.6 IL6 TNF
14 upper gum cancer 10.5 IL6 TNF
15 potato nose 10.5 IL6 TNF
16 central nervous system leiomyosarcoma 10.5 IL6 TNF
17 spondylocostal dysostosis 4 10.5 LTA TNF
18 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.5 IL6 TNF
19 type 1 papillary adenoma of the kidney 10.5 LTA TNF
20 vogt-koyanagi-harada disease 10.5 IL6 TNF
21 phlyctenulosis 10.5 IL6 TNF
22 islet cell tumor 10.5 IL6 TNF
23 idiopathic dilatation of the pulmonary artery 10.5 LTA TNF
24 early-onset zonular cataract 10.5 IL6 TNF
25 liver leiomyoma 10.5 LTA TNF
26 placental abruption 10.5 IL6 TNF
27 oculomotor nerve paralysis 10.5 CXCL8 IL6
28 hepadnavirus infection 10.5 IL6 TNF
29 cauda equina syndrome 10.5 LTA TNF
30 common peroneal nerve lesion 10.5 CXCL8 IL6
31 kernicterus due to isoimmunization 10.5 LTA TNF
32 tracheal stenosis 10.5 IL6 TNF
33 drug rash with eosinophilia and systemic symptoms 10.5 CXCL8 IL6
34 solitary plasmacytoma of chest wall 10.5 IL2 IL6
35 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.5 IL6 TNF
36 ulcerative colitis 10.5 IL6 TNF
37 schwannoma of ureter 10.5 CXCL8 IL6
38 psychotic disorder 10.5 CXCL8 IL6
39 kallmann syndrome 3 10.5 IL2 LTA
40 ampulla of vater neoplasm 10.5 IL6 TNF
41 infancy electroclinical syndrome 10.5 CXCL8 IL6
42 x-linked dominant intellectual disability-epilepsy syndrome 10.5 IL2 IL6
43 benign neonatal seizures 10.5 IL6 TNF
44 pityriasis rosea 10.5 IL6 TNF
45 acute myeloblastic leukemia without maturation 10.5 CXCL8 IL6
46 keloids 10.5 IL6 TNF
47 rheumatic myocarditis 10.5 IL6 TNF
48 conduct disorder 10.5 IL6 TNF
49 osteogenesis imperfecta, type x 10.5 CXCL8 IL6
50 intracranial arteriosclerosis 10.5 IL6 TNF

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4 13292-46-1 5458213 5381226
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Rho(D) Immune Globulin Phase 4,Phase 2
8 gamma-Globulins Phase 4,Phase 2
9 Pharmaceutical Solutions Phase 4,Phase 2
10 Immunoglobulins Phase 4,Phase 2
11 Immunoglobulins, Intravenous Phase 4,Phase 2
12 Antibodies Phase 4,Phase 2
13 Clavulanic Acid Phase 4
14 Clindamycin palmitate Phase 4
15 Clindamycin phosphate Phase 4
16 Amoxicillin-Potassium Clavulanate Combination Phase 4
17 Antibiotics, Antitubercular Phase 4
18 beta-Lactamase Inhibitors Phase 4
19 proline Nutraceutical Phase 4
20 methicillin
21 Vaccines

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin
2 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Recruiting NCT02219165 Phase 2 Intravenous human immunoglobulin;Albumin
3 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
4 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
5 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
6 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

39
Colon, T Cells, Skin, Monocytes, Eye

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 187)
id Title Authors Year
1
Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited. ( 27983484 )
2017
2
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus, United Kingdom. ( 27983491 )
2017
3
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
4
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2017
5
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
6
Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report. ( 28762570 )
2017
7
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
8
Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. ( 28698738 )
2017
9
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
10
Right in Front of Our Eyes: Evolution of Streptococcal Toxic Shock Syndrome with Ischemic Optic Neuropathy. ( 27903001 )
2016
11
A fatal case of streptococcal toxic shock syndrome caused by Streptococcus suis carrying tet (40) and tet (O/W/32/O), Italy. ( 27553071 )
2016
12
Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK. ( 26861052 )
2016
13
Intrauterine device infection causing concomitant streptococcal toxic shock syndrome and pelvic abscess with Actinomyces odontolyticus bacteraemia. ( 26965406 )
2016
14
Recurrent SDSE bacteraemia resulting in streptococcal toxic shock syndrome in a patient with Noonan syndrome. ( 27485878 )
2016
15
Streptococcal Toxic Shock Syndrome: Life Saving Role of Peritoneal Lavage and Drainage. ( 27579001 )
2016
16
Profuse watery diarrhoea: An unusual presenting feature of streptococcal toxic shock syndrome. ( 27124845 )
2016
17
Group A streptococcal toxic shock syndrome secondary to necrotizing pelvic inflammatory disease in a postmenopausal woman. ( 27419069 )
2016
18
Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence. ( 27349341 )
2016
19
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012. ( 25703404 )
2015
20
Management of primary iliopsoas abscess in an immunocompetent patient followed by streptococcal toxic shock syndrome: A case report. ( 27489682 )
2015
21
Streptococcal toxic shock syndrome secondary to group AA Streptococcus vaginitis. ( 26386777 )
2015
22
Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. ( 26025992 )
2015
23
Treatment of postoperative purulent pericarditis and streptococcal toxic shock syndrome by intensive blood purification. ( 25228196 )
2014
24
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome. ( 25313253 )
2014
25
Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study. ( 24928291 )
2014
26
Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient. ( 24464696 )
2014
27
Case of streptococcal toxic shock syndrome caused by rapidly progressive group A hemolytic streptococcal infection during postoperative chemotherapy for cervical cancer. ( 23937219 )
2014
28
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24780814 )
2014
29
Cases of death due to serious group A streptococcal toxic shock syndrome in pregnant females in Japan. ( 25194311 )
2014
30
Streptococcal toxic shock syndrome complicating a peritonsillar abscess. ( 25342572 )
2014
31
Necrotizing fasciitis and streptococcal toxic shock syndrome secondary to varicella in a healthy child. ( 25653688 )
2014
32
Phlegmonous gastritis associated with group a streptococcal toxic shock syndrome. ( 25400190 )
2014
33
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2014
34
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24112488 )
2013
35
A fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis possibly caused by an intramuscular injection. ( 23370754 )
2013
36
Streptococcal toxic shock syndrome secondary to a deep neck space infection presenting with no throat or neck symptoms. ( 23709536 )
2013
37
Trivial trauma, lethal outcome: streptococcal toxic shock syndrome presenting to the ED. ( 23702056 )
2013
38
Streptococcal Toxic Shock Syndrome. ( 24297338 )
2013
39
Fatal streptococcal toxic shock syndrome from an intrauterine device. ( 23394954 )
2013
40
Palpable purpura complicated by streptococcal toxic shock syndrome resulting in limb necrosis and amputation: a case of levamisole and cocaine coingestion. ( 22392427 )
2012
41
A case of streptococcal toxic shock syndrome due to Group G streptococci identified as Streptococcus dysgalactiae subsp. equisimilis. ( 22327489 )
2012
42
Complete genome sequence of Streptococcus pyogenes M1 476, isolated from a patient with streptococcal toxic shock syndrome. ( 22965090 )
2012
43
Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS). ( 21223537 )
2011
44
Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome. ( 21673039 )
2011
45
Clinical characteristics of children with group A streptococcal toxic shock syndrome admitted to pediatric intensive care units. ( 20981441 )
2011
46
Saline breast implant fluid collection and reactive arthritis in a patient with streptococcal toxic shock syndrome. ( 21325958 )
2011
47
Systemic cytokine response in moribund mice of streptococcal toxic shock syndrome model. ( 21146602 )
2011
48
Travel-related Streptococcal toxic shock syndrome caused by emm type 78 Streptococcus pyogenes. ( 21632896 )
2011
49
Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. ( 21460306 )
2011
50
Intrauterine fetal demise due to streptococcal toxic shock syndrome: a case report. ( 21077531 )
2010

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CXCL8 IL2 IL6 LTA TNF
2
Show member pathways
13.34 CXCL8 IL2 IL6 LTA TNF
3
Show member pathways
13.22 CXCL8 IL2 IL6 LTA TNF
4
Show member pathways
13.17 CXCL8 IL2 IL6 LTA TNF
5
Show member pathways
13.12 CXCL8 IL2 IL6 LTA TNF
6
Show member pathways
12.73 CXCL8 IL2 IL6 TNF
7
Show member pathways
12.64 IL2 IL6 LTA TNF
8
Show member pathways
12.62 CXCL8 IL2 IL6 LTA TNF
9
Show member pathways
12.55 IL2 IL6 LTA TNF
10
Show member pathways
12.55 CXCL8 IL2 IL6 LTA TNF
11
Show member pathways
12.29 IL2 IL6 TNF
12 12.26 IL2 IL6 LTA TNF
13
Show member pathways
12.2 CXCL8 IL6 TNF
14
Show member pathways
12.14 CXCL8 IL6 TNF
15
Show member pathways
12.06 CXCL8 IL6 TNF
16 12.05 CXCL8 IL6 TNF
17 11.89 IL2 IL6 TNF
18 11.88 CXCL8 IL6 TNF
19 11.85 IL6 LTA TNF
20 11.8 CXCL8 IL6 TNF
21 11.78 CXCL8 IL6 TNF
22 11.78 CXCL8 IL2 IL6 TNF
23 11.77 CXCL8 LTA TNF
24 11.74 CXCL8 IL6 TNF
25
Show member pathways
11.7 CXCL8 IL2 LTA
26 11.69 CXCL8 IL2 IL6
27 11.67 IL2 LTA TNF
28
Show member pathways
11.65 IL2 IL6 LTA TNF
29
Show member pathways
11.64 CXCL8 IL2 TNF
30 11.63 IL2 IL6 TNF
31 11.59 IL6 LTA TNF
32 11.53 CXCL8 IL6 TNF
33 11.45 CXCL8 IL6 TNF
34 11.44 C1S CXCL8 IL6 TNF
35
Show member pathways
11.42 LTA TNF
36 11.41 IL2 IL6 TNF
37 11.4 IL6 TNF
38 11.39 IL2 TNF
39 11.38 CXCL8 IL6 TNF
40 11.36 IL6 TNF
41 11.36 CXCL8 IL6 TNF
42
Show member pathways
11.31 IL2 TNF
43
Show member pathways
11.26 CXCL8 IL2 IL6 TNF
44 11.25 IL6 TNF
45 11.24 IL6 TNF
46 11.23 CXCL8 IL6
47
Show member pathways
11.23 CXCL8 IL2 IL6 LTA TNF
48 11.2 IL6 TNF
49 11.18 IL6 TNF
50 11.1 IL2 LTA

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CXCL8 IL2 IL6 LTA TNF
2 extracellular region GO:0005576 9.1 C1S CXCL8 IL2 IL6 LTA TNF

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.65 CXCL8 IL6 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.58 IL6 LTA TNF
3 negative regulation of fat cell differentiation GO:0045599 9.56 IL6 TNF
4 positive regulation of interleukin-6 production GO:0032755 9.55 IL6 TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IL6 TNF
6 embryonic digestive tract development GO:0048566 9.52 CXCL8 TNF
7 positive regulation of chemokine production GO:0032722 9.51 IL6 TNF
8 negative regulation of growth of symbiont in host GO:0044130 9.49 LTA TNF
9 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL2 IL6
10 negative regulation of lipid storage GO:0010888 9.43 IL6 TNF
11 humoral immune response GO:0006959 9.43 IL6 LTA TNF
12 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.37 IL6 TNF
13 positive regulation of interferon-gamma production GO:0032729 9.33 IL2 LTA TNF
14 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 LTA TNF
15 immune response GO:0006955 9.02 CXCL8 IL2 IL6 LTA TNF
16 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL2 IL6 LTA TNF
2 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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