MCID: STR001
MIFTS: 28

Striatonigral Degeneration malady

Categories: Neuronal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Striatonigral Degeneration

Aliases & Descriptions for Striatonigral Degeneration:

Name: Striatonigral Degeneration 12 51 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4751
ICD10 33 G23.2
MeSH 42 D020955
SNOMED-CT 64 29618004
UMLS 69 C0270733

Summaries for Striatonigral Degeneration

NINDS : 51 Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.

MalaCards based summary : Striatonigral Degeneration is related to striatonigral degeneration, infantile and striatonigral degeneration, childhood-onset. An important gene associated with Striatonigral Degeneration is SNCA (Synuclein Alpha). Affiliated tissues include brain, cerebellum and medulla oblongata.

Wikipedia : 71 Multiple system atrophy (MSA), also known as Shy-Drager syndrome, is a rare neurodegenerative disorder... more...

Related Diseases for Striatonigral Degeneration

Graphical network of the top 20 diseases related to Striatonigral Degeneration:



Diseases related to Striatonigral Degeneration

Symptoms & Phenotypes for Striatonigral Degeneration

Drugs & Therapeutics for Striatonigral Degeneration

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fipamezole in Neurogenic Orthostatic Hypotension Unknown status NCT00758849 Phase 2

Search NIH Clinical Center for Striatonigral Degeneration

Cochrane evidence based reviews: striatonigral degeneration

Genetic Tests for Striatonigral Degeneration

Anatomical Context for Striatonigral Degeneration

MalaCards organs/tissues related to Striatonigral Degeneration:

39
Brain, Cerebellum, Medulla Oblongata

Publications for Striatonigral Degeneration

Articles related to Striatonigral Degeneration:

(show top 50) (show all 78)
id Title Authors Year
1
A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic Acid into the striatum. ( 25408589 )
2014
2
Intrastriatal injection of colchicine induces striatonigral degeneration in mice. ( 18564367 )
2008
3
Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy). ( 15549330 )
2005
4
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( 15583958 )
2005
5
Effects of riluzole on combined MPTP + 3-nitropropionic acid-induced mild to moderate striatonigral degeneration in mice. ( 15503195 )
2005
6
MPTP potentiates 3-nitropropionic acid-induced striatal damage in mice: reference to striatonigral degeneration. ( 14697318 )
2004
7
Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration. ( 15372496 )
2004
8
Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy). ( 15056471 )
2004
9
Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy). ( 12764627 )
2003
10
A novel grading scale for striatonigral degeneration (multiple system atrophy). ( 11956953 )
2002
11
A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis. ( 12421620 )
2002
12
Thin section MR study of the basal ganglia in the differential diagnosis between striatonigral degeneration and Parkinson disease. ( 11884785 )
2002
13
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration. ( 11935266 )
2002
14
Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys. ( 12457736 )
2002
15
Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic Parkinson's disease from those with striatonigral degeneration. ( 12242540 )
2002
16
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy). ( 11226695 )
2001
17
FLAIR MRI of striatonigral degeneration. ( 11342686 )
2001
18
Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: a model of early-stage striatonigral degeneration. ( 11161601 )
2001
19
Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy). ( 10924951 )
2000
20
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesencephalic, striatal or co-grafts. ( 10658617 )
2000
21
Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration. ( 10830420 )
2000
22
Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy). ( 10877927 )
2000
23
Striatonigral degeneration with motor neuron disease. ( 10896276 )
2000
24
Neuropsychological follow up in patients with Parkinson's disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy. ( 10945805 )
2000
25
Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration. ( 10661519 )
2000
26
An early description of striatonigral degeneration. ( 10836627 )
2000
27
In vivo magnetic resonance imaging of embryonic neural grafts in a rat model of striatonigral degeneration (multiple system atrophy). ( 10913326 )
2000
28
Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson's disease. ( 10896267 )
2000
29
An early description of striatonigral degeneration. ( 10431772 )
1999
30
Cortical and brain stem hyperexcitability in striatonigral degeneration. ( 9613764 )
1998
31
Differentiation of idiopathic Parkinson's disease from striatonigral degeneration and progressive supranuclear palsy using iodine-123 meta-iodobenzylguanidine myocardial scintigraphy. ( 9562324 )
1998
32
Increased basal ganglia iron in striatonigral degeneration: in vivo estimation with magnetic resonance. ( 9532280 )
1998
33
Correlative studies of MR findings with neuropathology in Shy-Drager syndrome and striatonigral degeneration. ( 9594269 )
1997
34
Medial pallidotomy in late-stage Parkinson's disease and striatonigral degeneration. ( 9348415 )
1997
35
Urinary disturbances in striatonigral degeneration and Parkinson's disease: clinical and urodynamic aspects. ( 9251068 )
1997
36
MRI in sporadic olivopontocerebellar atrophy and striatonigral degeneration. ( 9065575 )
1997
37
Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration. ( 8857740 )
1996
38
Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration. ( 8866493 )
1996
39
"Pure" striatonigral degeneration and Parkinson's disease: a comparative clinical study. ( 7651445 )
1995
40
Neuroleptic malignant syndrome in striatonigral degeneration. ( 8554665 )
1995
41
Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state. ( 7550604 )
1995
42
Neuropsychological pattern of striatonigral degeneration: comparison with Parkinson's disease and progressive supranuclear palsy. ( 7876847 )
1995
43
Striatal opioid receptor binding in Parkinson's disease, striatonigral degeneration and Steele-Richardson-Olszewski syndrome, A [11C]diprenorphine PET study. ( 7655890 )
1995
44
Striatonigral degeneration: iron deposition in putamen correlates with the slit-like void signal of magnetic resonance imaging. ( 7533048 )
1994
45
Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease. ( 8498828 )
1993
46
Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study. ( 8505636 )
1993
47
Striatonigral degeneration with neurofibrillary tangles. ( 8256593 )
1993
48
Striatal D2 receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with 11C-raclopride and positron emission tomography. ( 1575457 )
1992
49
Increased iron content in the putamen of patients with striatonigral degeneration. ( 1414283 )
1992
50
Neuropsychological deficits accompanying striatonigral degeneration. ( 1955531 )
1991

Variations for Striatonigral Degeneration

Expression for Striatonigral Degeneration

Search GEO for disease gene expression data for Striatonigral Degeneration.

Pathways for Striatonigral Degeneration

GO Terms for Striatonigral Degeneration

Cellular components related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon terminus GO:0043679 8.96 DRD2 SNCA
2 intracellular membrane-bounded organelle GO:0043231 8.92 ATP2B3 NUP62 SNCA VAC14

Biological processes related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 9.4 DRD2 MAP2
2 response to cocaine GO:0042220 9.37 DRD2 SNCA
3 regulation of dopamine secretion GO:0014059 9.32 DRD2 SNCA
4 behavioral response to cocaine GO:0048148 9.26 DRD2 SNCA
5 synaptic transmission, dopaminergic GO:0001963 9.16 DRD2 SNCA
6 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 DRD2 SNCA
7 dopamine metabolic process GO:0042417 8.62 DRD2 SNCA

Molecular functions related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.16 NUP62 SNCA
2 kinesin binding GO:0019894 8.96 NUP62 SNCA
3 Hsp70 protein binding GO:0030544 8.62 NUP62 SNCA

Sources for Striatonigral Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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