Striatonigral Degeneration malady

NINDS: Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.³¹

MalaCards: Striatonigral Degeneration is related to multiple system atrophy and dementia. An important gene associated with Striatonigral Degeneration is NUP62 (nucleoporin 62kDa), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Amine ligand-binding receptors. The compounds 1-benzyl-1,2,3,4-tetrahydroisoquinoline and thioflavine s have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotype taste/olfaction.

Genetics Home Reference: Multiple system atrophy is a progressive brain disorder that affects movement and balance and disrupts the function of the autonomic nervous system. The autonomic nervous system controls body functions that are mostly involuntary, such as regulation of blood pressure.¹⁷

Wikipedia: Multiple-system atrophy (MSA) is a degenerativeneurological disorder. MSA is associated with the...⁴⁴ more...

Aliases & Descriptions:

striatonigral degeneration 6 7 31 8 32 43

Diseases related to striatonigral degeneration by text searches and GeneDecks gene sharing:

(show top 50)    (show all 88)

id	Related Disease	Score	Top Affiliating Genes
1	multiple system atrophy	28.2	SLC6A3, RPS27A, SNCA, DRD2, MAP2, STRN
2	dementia	27.5	MAP2, DRD2, RPS27A, SLC6A3, SNCA
3	parkinson's disease	26.3	MAP2, DRD1, SNCA, RPS27A, SLC6A3, DRD2
4	dysphagia	13.0	RPS27A, NUP62
5	central neurocytoma	13.0	SNCA, MAP2
6	leptin receptor deficiency	13.0	DRD2, SLC6A3
7	striatal degeneration	12.9	SLC6A3, NUP62
8	neuronal intranuclear inclusion disease	12.9	SNCA, RPS27A
9	neuroaxonal dystrophy	12.9	RPS27A, SNCA
10	antisocial personality disorder	12.9	DRD2, SLC6A3
11	sepiapterin reductase deficiency	12.9	SLC6A3, DRD2
12	corticobasal degeneration	12.9	RPS27A, SNCA
13	inclusion body myopathy	12.9	RPS27A, SNCA
14	vascular dementia	12.9	RPS27A, SNCA
15	manic-depressive illness	12.9	DRD2, SLC6A3
16	tauopathy	12.8	SNCA, RPS27A
17	creutzfeldt-jakob syndrome	12.8	RPS27A, SNCA
18	olivopontocerebellar atrophy	12.8	SNCA, RPS27A
19	opiate dependence	12.8	SLC6A3, DRD2
20	personality disorder	12.8	DRD2, SLC6A3
21	heroin dependence	12.8	DRD2, SLC6A3
22	migraine with aura	12.7	DRD2, SLC6A3
23	ppm-x syndrome	12.7	DRD2, SLC6A3
24	anxiety disorder	12.7	SLC6A3, DRD2
25	gilles de la tourette syndrome	12.7	SLC6A3, DRD2
26	aphasia	12.7	RPS27A, SNCA
27	ganglioglioma	12.7	MAP2, SNCA
28	autonomic dysfunction	12.6	RPS27A, SNCA
29	gliosis	12.5	MAP2, SNCA, RPS27A
30	paralysis	12.5	DRD2, RPS27A, SNCA
31	alcohol abuse	12.5	RPS27A, SLC6A3, DRD2
32	dyskinesia of esophagus	12.5	SLC6A3, DRD2
33	growth mental deficiency syndrome of myhre	12.5	SLC6A3, DRD2
34	cocaine abuse	12.4	DRD2, SLC6A3, SNCA
35	rem sleep behavior disorder	12.4	SNCA, RPS27A, SLC6A3
36	tremor	12.4	DRD2, SNCA, SLC6A3
37	substance dependence	12.4	SLC6A3, DRD2
38	lewy body dementia	12.4	RPS27A, SNCA, SLC6A3
39	spinocerebellar ataxia type 3	12.4	SLC6A3, SNCA, RPS27A
40	chorea	12.3	MAP2, RPS27A
41	transient cerebral ischemia	12.3	MAP2, DRD1, RPS27A
42	drug addiction	12.2	SLC6A3, DRD1, DRD2
43	pathological gambling	12.2	SLC6A3, DRD1, DRD2
44	cocaine dependence	12.1	DRD1, SLC6A3, DRD2
45	substance abuse	12.1	DRD2, DRD1, SLC6A3
46	tardive dyskinesia	12.1	DRD1, DRD2, SLC6A3
47	obsessive-compulsive disorder	12.1	DRD1, DRD2, SLC6A3
48	nicotine dependence	12.1	DRD2, SLC6A3, DRD1
49	tourette syndrome	12.1	DRD1, SLC6A3, DRD2
50	bipolar affective disorder	12.1	DRD1, DRD2, SLC6A3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to striatonigral degeneration:

²²

MGI Mouse Phenotypes related to striatonigral degeneration:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.1	DRD2, SNCA, SLC6A3

Articles related to striatonigral degeneration:

id	Title	Authors	Year	Affiliating Genes
1	Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration. (11935266)	GA^mez-Tortosa E.... Hyman B.T.	2002	SNCA
2	Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration. (10661519)	GonzA!lez A.M.... Pascual J.	2000	DRD2
3	Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study. (8505636)	Shinotoh H.... Tateno Y.	1993	DRD1

Genes related to striatonigral degeneration according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	NUP62	nucleoporin 62kDa	11.0
2	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
3	DRD2	dopamine receptor D2	11.0	Publications
4	MAP2	microtubule-associated protein 2	11.0
5	RPS27A	ribosomal protein S27a	11.0
6	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0
7	DRD1	dopamine receptor D1	11.0	Publications
8	STRN	striatin, calmodulin binding protein	11.0

Pathways related to striatonigral degeneration according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	9.2	DRD1, DRD2
2	Amine ligand-binding receptors38	8.9	DRD1, DRD2

Compounds related to striatonigral degeneration according to GeneDecks:

(show top 50)    (show all 90)

id	Compound	Score	Top Affiliating Genes
1	1-benzyl-1,2,3,4-tetrahydroisoquinoline32	9.9	SLC6A3, SNCA
2	thioflavine s32	9.8	RPS27A, SNCA
3	ibzm32	9.8	DRD2, SLC6A3
4	alpha-methyl-p-tyrosine32	9.7	DRD2, SLC6A3
5	eticlopride32	9.6	DRD1, DRD2
6	skf 3839332	9.6	DRD1, DRD2
7	(+)-butaclamol32	9.6	DRD1, DRD2
8	Acetophenazine9 9	10.6	DRD2, DRD1
9	Thiethylperazine9 9	10.6	DRD1, DRD2
10	Carphenazine9 9	10.6	DRD1, DRD2
11	eedq32	9.5	DRD2, DRD1
12	Triflupromazine9 9	10.5	DRD1, DRD2
13	spiperone32	9.4	DRD2, DRD1
14	loxapine32 9 9	11.4	DRD1, DRD2
15	Thiothixene9 9	10.4	DRD1, DRD2
16	sch 2339032	9.4	DRD2, DRD1
17	zuclopenthixol32 34 9 9	12.3	DRD2, DRD1
18	rotenone32	9.3	SNCA, RPS27A, SLC6A3
19	Acepromazine9 9	10.2	DRD1, DRD2
20	silver32	9.1	RPS27A, SNCA, MAP2
21	d amphetamine32	9.1	SLC6A3, DRD2, DRD1
22	raclopride32 42	10.0	DRD2, SLC6A3, DRD1
23	methylphenidate32 9 9	11.0	DRD1, DRD2, SLC6A3
24	trimipramine32 34 9 9	12.0	DRD1, DRD2, SLC6A3
25	sulpiride32 9 9	11.0	DRD1, DRD2, SLC6A3
26	quinpirole32	9.0	DRD2, DRD1, SLC6A3
27	pramipexole32 9 9	11.0	DRD1, DRD2, SLC6A3
28	ketamine32 9 9	11.0	DRD1, DRD2, SLC6A3
29	risperidone32 34 9 18 9	13.0	DRD1, SLC6A3, DRD2
30	spec-t32	9.0	DRD2, SLC6A3, DRD1
31	quetiapine32 9 18 9	12.0	DRD1, SLC6A3, DRD2
32	bromocriptine32 9 9	10.9	SLC6A3, DRD1, DRD2
33	olanzapine32 34 9 18 9	12.9	SLC6A3, DRD2, DRD1
34	opiate32	8.9	DRD1, DRD2, SLC6A3
35	apomorphine32 9 9	10.7	DRD1, DRD2, SLC6A3, SNCA
36	amphetamine32 9 9	10.7	DRD1, SLC6A3, SNCA, DRD2
37	clozapine32 34 9 9	11.5	DRD1, DRD2, SLC6A3
38	haloperidol32 34 9 9	11.3	SLC6A3, DRD1, DRD2
39	adenylate32	8.3	DRD2, SNCA, MAP2, DRD1, RPS27A
40	cocaine32 9 9	10.2	SNCA, DRD2, MAP2, DRD1, SLC6A3
41	norepinephrine32 9 18 9	11.2	MAP2, DRD1, DRD2, SLC6A3, SNCA
42	6-hydroxydopamine32	8.2	SLC6A3, DRD2, DRD1, RPS27A, SNCA
43	mptp32	8.2	SLC6A3, RPS27A, SNCA, DRD1, DRD2
44	levodopa32 9 9	10.2	SLC6A3, RPS27A, SNCA, DRD2, DRD1
45	acetylcholine32 9 18 9	11.1	DRD2, SNCA, RPS27A, SLC6A3, DRD1
46	gaba32 42	9.1	DRD1, DRD2, RPS27A, SLC6A3, MAP2
47	nmda32 42	9.1	DRD1, DRD2, RPS27A, SLC6A3, MAP2
48	methamphetamine32 9 9	9.7	MAP2, RPS27A, SNCA, DRD2, DRD1, SLC6A3
49	dopamine32 9 18 9	10.7	RPS27A, SNCA, MAP2, DRD1, SLC6A3, DRD2
50	glutamate32	7.7	MAP2, SNCA, DRD1, DRD2, RPS27A, SLC6A3

Cellular components related to striatonigral degeneration according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	8.1	MAP2, DRD1, STRN, SLC6A3
2	axon	GO:030424	7.9	DRD1, DRD2, SNCA, SLC6A3

Biological processes related to striatonigral degeneration according to GeneDecks:

(show all 30)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of dopamine secretion	GO:014059	10.0	SNCA, DRD2
2	dopamine biosynthetic process	GO:042416	9.8	SLC6A3, SNCA
3	adenohypophysis development	GO:021984	9.8	SLC6A3, DRD2
4	response to iron ion	GO:010039	9.7	DRD2, SLC6A3
5	negative regulation of circadian sleep/wake cycle, sleep	GO:042321	9.6	DRD1, DRD2
6	response to cocaine	GO:042220	9.6	DRD2, SLC6A3
7	regulation of dopamine uptake involved in synaptic transmission	GO:051584	9.6	DRD1, DRD2
8	phospholipase C-activating dopamine receptor signaling pathway	GO:060158	9.6	DRD1, DRD2
9	cerebral cortex GABAergic interneuron migration	GO:021853	9.6	DRD1, DRD2
10	response to nicotine	GO:035094	9.6	DRD2, SLC6A3
11	behavioral response to cocaine	GO:048148	9.6	DRD1, DRD2
12	peristalsis	GO:030432	9.6	DRD1, DRD2
13	positive regulation of multicellular organism growth	GO:040018	9.6	DRD2, SLC6A3
14	dopamine metabolic process	GO:042417	9.5	DRD1, DRD2
15	synaptic transmission, dopaminergic	GO:001963	9.5	DRD1, DRD2
16	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	GO:051482	9.5	DRD2, DRD1
17	long-term synaptic potentiation	GO:060291	9.5	DRD1, SNCA
18	grooming behavior	GO:007625	9.5	DRD2, DRD1
19	positive regulation of release of sequestered calcium ion into cytosol	GO:051281	9.5	DRD1, SNCA
20	temperature homeostasis	GO:001659	9.4	DRD2, DRD1
21	regulation of dopamine metabolic process	GO:042053	9.4	SLC6A3, DRD1
22	adult walking behavior	GO:007628	9.3	DRD2, DRD1
23	negative regulation of epidermal growth factor receptor signaling pathway	GO:042059	9.3	RPS27A, NUP62
24	locomotory behavior	GO:007626	9.3	SLC6A3, STRN, DRD2
25	regulation of long-term neuronal synaptic plasticity	GO:048169	9.3	DRD1, DRD2, SNCA
26	response to amphetamine	GO:001975	9.2	DRD1, DRD2
27	synapse assembly	GO:007416	9.2	DRD1, DRD2
28	visual learning	GO:008542	9.1	DRD1, DRD2
29	prepulse inhibition	GO:060134	9.0	DRD1, DRD2, SLC6A3
30	response to drug	GO:042493	8.6	SLC6A3, SNCA, DRD2, DRD1

Molecular functions related to striatonigral degeneration according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	dopamine binding	GO:035240	8.5	DRD1, DRD2, SLC6A3
2	drug binding	GO:008144	8.3	DRD1, DRD2, SLC6A3
3	protein binding	GO:005515	6.9	NUP62, STRN, SNCA, DRD2, DRD1, MAP2