MCID: STR001
MIFTS: 34

Striatonigral Degeneration malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Striatonigral Degeneration

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Aliases & Descriptions for Striatonigral Degeneration:

Name: Striatonigral Degeneration 10 46 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:4751
ICD1027 G23.2
SNOMED-CT59 29618004
MeSH36 D020955
UMLS65 C0270733

Summaries for Striatonigral Degeneration

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NINDS:46 Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.

MalaCards based summary: Striatonigral Degeneration is related to striatonigral degeneration, infantile and familial infantile bilateral striatal necrosis. An important gene associated with Striatonigral Degeneration is NUP62 (Nucleoporin 62kDa), and among its related pathways are Hypothetical Network for Drug Addiction and Parkinsons Disease Pathway. Affiliated tissues include brain, breast and colon, and related mouse phenotypes are taste/olfaction and nervous system.

Wikipedia:68 Multiple system atrophy (MSA) is a degenerativeneurological disorder. MSA is associated with the... more...

Related Diseases for Striatonigral Degeneration

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Diseases in the Striatonigral Degeneration family:

Striatonigral Degeneration, Infantile

Diseases related to Striatonigral Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1striatonigral degeneration, infantile12.9
2familial infantile bilateral striatal necrosis11.8
3sporadic infantile bilateral striatal necrosis11.8
4multiple system atrophy11.6
5mitochondrial infantile bilateral striatal necrosis11.6
6machado-joseph disease11.5
7multiple system atrophy, parkinsonian type10.6
8hepatitis10.3
9cerebritis10.3
10esophagus carcinoma in situ10.2SLC6A3, SNCA
11supranuclear palsy, progressive atypical10.1SLC6A3, SNCA
12kluver-bucy syndrome10.1DRD2, SLC6A3
13prostate adenocarcinoma10.1DRD2, SLC6A3
14prostate cancer10.1
15bacteremia10.1
16obsessive-compulsive disorder10.1
17insulin-like growth factor i10.1
18pulmonary hypertension10.1
19atherosclerosis10.1
20b-cell lymphomas10.1
21cataract10.1
22diffuse large b-cell lymphoma10.1
23hematopoietic stem cell transplantation10.1
24hydrocephalus10.1
25leukemia10.1
26pemphigus foliaceus10.1
27pemphigus vulgaris10.1
28lymphoma10.1
29cerebral artery occlusion10.1
30common cold10.1
31petrositis10.1
32sarcoma10.1
33pericardial effusion10.1
34cortical blindness10.1
35cushing's syndrome10.1
36urethritis10.1
37tuberous sclerosis10.1
38neuroschistosomiasis10.1
39opisthorchiasis10.1
40prostatitis10.1
41duodenal ulcer10.1
42hepatitis c10.1
43melanoma10.1
44leiomyosarcoma10.1
45ischemia10.1
46craniopharyngioma10.1
47tuberculosis10.1
48multidrug-resistant tuberculosis10.1
49syphilis10.1
50pancreatitis10.1

Graphical network of the top 20 diseases related to Striatonigral Degeneration:



Diseases related to striatonigral degeneration

Symptoms for Striatonigral Degeneration

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Drugs & Therapeutics for Striatonigral Degeneration

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Fipamezole in Neurogenic Orthostatic HypotensionNot yet recruitingNCT00758849Phase 2

Search NIH Clinical Center for Striatonigral Degeneration


Cochrane evidence based reviews: striatonigral degeneration

Genetic Tests for Striatonigral Degeneration

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Anatomical Context for Striatonigral Degeneration

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MalaCards organs/tissues related to Striatonigral Degeneration:

33
Brain, Breast, Colon, Heart, Liver, Cervix, Lung

Animal Models for Striatonigral Degeneration or affiliated genes

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MGI Mouse Phenotypes related to Striatonigral Degeneration:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.7DRD2, SLC6A3, SNCA
2MP:00036317.5DRD1, DRD2, MAP2, SLC6A3, SNCA
3MP:00053867.2DRD1, DRD2, MAP2, SLC6A3, SNCA

Publications for Striatonigral Degeneration

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Articles related to Striatonigral Degeneration:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Recent advances in the understanding and care of familial hypercholesterolaemia: significance of the biology and therapeutic regulation of proprotein convertase subtilisin/kexin typeA 9. (25881720)
2015
2
Temporary conduction block in acute motor axonal neuropathy. (26442689)
2015
3
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. (25264606)
2014
4
Anaplastic Solitary plasmacytoma of mandible, masquerading as sarcoma. (24353648)
2013
5
What are Patient Beliefs and Perceptions about Exercise for Non-specific Chronic Low Back Pain? A Systematic Review of Qualitative Studies. (24300225)
2013
6
CYP2D6 and adjuvant tamoxifen: possible differences of outcome in pre- and post-menopausal patients. (23570465)
2013
7
Novel Dynein DYNC1H1 Neck and Motor Domain Mutations Link Distal Spinal Muscular Atrophy and Abnormal Cortical Development. (24307404)
2013
8
Polyarteritis nodosa presenting as haematuria following strenuous exercise. (23188866)
2012
9
Sodium Supplementation in Neonates With Pierre Robin Sequence Significantly Improves Weight Gain if Urinary Sodium Is Low. (21265661)
2012
10
Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B. (22565846)
2012
11
Late primary arterial switch for transposition of the great arteries with intact ventricular septum in an african population. (23804978)
2011
12
Excess of serotonin affects neocortical pyramidal neuron migration. (22833193)
2011
13
Acute pancreatitis associated with hypertriglyceridemia: a life-threatening complication. (19657666)
2010
14
The orbicularis oculi muscle flap: its use for treatment of lagophthalmos and a review of its use for other applications. (19147419)
2010
15
PPIase domain of trigger factor acts as auxiliary chaperone site to assist the folding of protein substrates bound to the crevice of trigger factor. (20096367)
2010
16
Power-laws in interferon-B mRNA distribution in virus-infected dendritic cells. (19804729)
2009
17
Novel mutations of CYP3A4 in fine needle aspiration cytology samples of breast cancer patients and its clinical correlations. (19242060)
2009
18
Intragenic deletion of TRIM32 in compound heterozygotes with sarcotubular myopathy/LGMD2H. (19492423)
2009
19
Conformational changes in p47(phox) upon activation highlighted by mass spectrometry coupled to hydrogen/deuterium exchange and limited proteolysis. (19192478)
2009
20
Fatal haemoptysis in a young man with tuberculous mediastinal lymphadenitis. A case report and review of the literature. (18219195)
2009
21
Vaccine against infectious bovine keratoconjunctivitis: a new approach to optimize the production of highly piliated Moraxella bovis cells. (18852003)
2008
22
Autosomal dominant familial neurohypophyseal diabetes insipidus caused by a novel mutation in arginine-vasopressin gene in a Brazilian family. (19169480)
2008
23
Effect of 14-3-3sigma on transcriptional activity of p73 gene]. (17672938)
2007
24
Germline mutation of INI1/SMARCB1 in familial schwannomatosis. (17357086)
2007
25
Perfidious gallbladders - a diagnostic dilemma with xanthogranulomatous cholecystitis. (17346415)
2007
26
Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. (23132986)
2007
27
Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men. (17229646)
2007
28
Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene. (17451432)
2007
29
DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. (17983803)
2007
30
Acquired capillary hemangioma in the lacrimal sac region. (17056377)
2006
31
Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin. (15069014)
2004
32
Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells. (12836164)
2003
33
Energy status and its control on embryogenesis of legumes. Embryo photosynthesis contributes to oxygen supply and is coupled to biosynthetic fluxes. (12857802)
2003
34
Diastolic ventricular dysfunction as a marker for hypertrophic cardiomyopathy in a family with a novel alpha-tropomyosin mutation. (12778034)
2003
35
Relationship between the Nco I, Ava II polymorphism of low density lipoprotein receptor gene and atherosclerotic cerebral infarction]. (12048680)
2002
36
Structural insights into the molecular mechanism of calcium-dependent vesicle-membrane fusion. (11297924)
2001
37
Association of lower genital tract inflammation with objective evidence of endometritis. (10805362)
2000
38
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (10888872)
2000
39
Urokinase type plasminogen activator receptor expression in colorectal neoplasms. (9824607)
1998
40
Basaloid follicular hamartoma, total body hair loss and SLE. (9607646)
1998
41
Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations. (8799813)
1996
42
German health economic cost evaluation on oral ganciclovir in treating cytomegalovirus retinitis. (10172869)
1996
43
Protein C, protein S and antithrombin III levels in the course of bone marrow and subsequent liver transplantation due to veno-occlusive disease. (9438165)
1996
44
Immunopositive GABAergic neural sites display nitric oxide synthase-related NADPH diaphorase activity in the human colon. (7536225)
1995
45
Morning glory disc anomaly or optic disc coloboma? (8311757)
1994
46
Plasma protein C and antithrombin III in patients with acute leukemia. (7866337)
1994
47
Therapeutic safety of perindopril in the treatment of mild hypertension with concomitant nephropathy. (8216441)
1993
48
Cloned receptors and cardiovascular responses to adenosine. (8458033)
1993
49
Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. (6581542)
1983
50
Cerebral metastasis of alveolar soft-part sarcoma. Report of a case of long postoperative survival. (4474855)
1974

Variations for Striatonigral Degeneration

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Expression for genes affiliated with Striatonigral Degeneration

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Search GEO for disease gene expression data for Striatonigral Degeneration.

Pathways for genes affiliated with Striatonigral Degeneration

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GO Terms for genes affiliated with Striatonigral Degeneration

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Cellular components related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.6DRD1, DRD2, SLC6A3

Biological processes related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1protein import into nucleusGO:00066069.8DRD1, NUP62
2peristalsisGO:00304329.8DRD1, DRD2
3negative regulation of cell migrationGO:00303369.8DRD1, DRD2
4response to nicotineGO:00350949.8DRD1, DRD2
5response to amphetamineGO:00019759.8DRD1, DRD2
6prepulse inhibitionGO:00601349.8DRD1, DRD2
7phospholipase C-activating dopamine receptor signaling pathwayGO:00601589.8DRD1, DRD2
8visual learningGO:00085429.8DRD1, DRD2
9long-term synaptic potentiationGO:00602919.8DRD1, SNCA
10dopamine receptor signaling pathwayGO:00072129.7DRD1, DRD2
11positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:00514829.7DRD1, DRD2
12feeding behaviorGO:00076319.6DRD1, DRD2
13grooming behaviorGO:00076259.6DRD1, DRD2
14temperature homeostasisGO:00016599.6DRD1, DRD2
15response to morphineGO:00432789.5DRD1, DRD2
16response to ethanolGO:00454719.5DRD2, SLC6A3
17associative learningGO:00083069.5DRD1, DRD2
18regulation of dopamine metabolic processGO:00420539.4DRD1, SLC6A3
19negative regulation of circadian sleep/wake cycle, sleepGO:00423219.4DRD1, DRD2
20behavioral response to cocaineGO:00481489.4DRD1, DRD2
21dopamine transportGO:00158729.4DRD1, SLC6A3
22regulation of dopamine uptake involved in synaptic transmissionGO:00515849.3DRD1, DRD2
23regulation of long-term neuronal synaptic plasticityGO:00481699.3DRD1, DRD2, SNCA
24synaptic transmission, dopaminergicGO:00019639.2DRD1, DRD2, SNCA
25orbitofrontal cortex developmentGO:00217699.1DRD1, DRD2
26locomotory behaviorGO:00076268.9DRD1, DRD2, SLC6A3
27response to drugGO:00424938.5DRD1, DRD2, SLC6A3, SNCA

Sources for Striatonigral Degeneration

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet