MCID: STR001
MIFTS: 32

Striatonigral Degeneration malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Striatonigral Degeneration

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Aliases & Descriptions for Striatonigral Degeneration:

Name: Striatonigral Degeneration 11 47 13 48 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:4751
ICD1028 G23.2
SNOMED-CT60 29618004
MeSH37 D020955

Summaries for Striatonigral Degeneration

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NINDS:47 Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.

MalaCards based summary: Striatonigral Degeneration is related to striatonigral degeneration, infantile and familial infantile bilateral striatal necrosis. An important gene associated with Striatonigral Degeneration is NUP62 (Nucleoporin 62), and among its related pathways are Amphetamine addiction and Monoamine GPCRs. Affiliated tissues include brain, cerebellum and medulla oblongata.

Wikipedia:69 Multiple system atrophy (MSA) is a degenerativeneurological disorder that depicts a group of disorders... more...

Related Diseases for Striatonigral Degeneration

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Graphical network of the top 20 diseases related to Striatonigral Degeneration:



Diseases related to striatonigral degeneration

Symptoms for Striatonigral Degeneration

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Drugs & Therapeutics for Striatonigral Degeneration

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Fipamezole in Neurogenic Orthostatic HypotensionNot yet recruitingNCT00758849Phase 2

Search NIH Clinical Center for Striatonigral Degeneration


Cochrane evidence based reviews: striatonigral degeneration

Genetic Tests for Striatonigral Degeneration

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Anatomical Context for Striatonigral Degeneration

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MalaCards organs/tissues related to Striatonigral Degeneration:

34
Brain, Cerebellum, Medulla oblongata

Animal Models for Striatonigral Degeneration or affiliated genes

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Publications for Striatonigral Degeneration

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Articles related to Striatonigral Degeneration:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic Acid into the striatum. (25408589)
2014
2
Intrastriatal injection of colchicine induces striatonigral degeneration in mice. (18564367)
2008
3
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). (15583958)
2005
4
Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy). (15549330)
2005
5
MPTP potentiates 3-nitropropionic acid-induced striatal damage in mice: reference to striatonigral degeneration. (14697318)
2004
6
Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy). (15056471)
2004
7
Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy). (12764627)
2003
8
Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic Parkinson's disease from those with striatonigral degeneration. (12242540)
2002
9
Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys. (12457736)
2002
10
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration. (11935266)
2002
11
A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis. (12421620)
2002
12
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy). (11226695)
2001
13
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesencephalic, striatal or co-grafts. (10658617)
2000
14
Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy). (10924951)
2000
15
An early description of striatonigral degeneration. (10836627)
2000
16
Neuropsychological follow up in patients with Parkinson's disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy. (10945805)
2000
17
In vivo magnetic resonance imaging of embryonic neural grafts in a rat model of striatonigral degeneration (multiple system atrophy). (10913326)
2000
18
Striatonigral degeneration with motor neuron disease. (10896276)
2000
19
Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy). (10877927)
2000
20
Increased basal ganglia iron in striatonigral degeneration: in vivo estimation with magnetic resonance. (9532280)
1998
21
Cortical and brain stem hyperexcitability in striatonigral degeneration. (9613764)
1998
22
Differentiation of idiopathic Parkinson's disease from striatonigral degeneration and progressive supranuclear palsy using iodine-123 meta-iodobenzylguanidine myocardial scintigraphy. (9562324)
1998
23
Correlative studies of MR findings with neuropathology in Shy-Drager syndrome and striatonigral degeneration. (9594269)
1997
24
MRI in sporadic olivopontocerebellar atrophy and striatonigral degeneration. (9065575)
1997
25
Medial pallidotomy in late-stage Parkinson's disease and striatonigral degeneration. (9348415)
1997
26
Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration. (8857740)
1996
27
Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration. (8866493)
1996
28
"Pure" striatonigral degeneration and Parkinson's disease: a comparative clinical study. (7651445)
1995
29
Neuropsychological pattern of striatonigral degeneration: comparison with Parkinson's disease and progressive supranuclear palsy. (7876847)
1995
30
Striatal opioid receptor binding in Parkinson's disease, striatonigral degeneration and Steele-Richardson-Olszewski syndrome, A [11C]diprenorphine PET study. (7655890)
1995
31
Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state. (7550604)
1995
32
Neuroleptic malignant syndrome in striatonigral degeneration. (8554665)
1995
33
Striatonigral degeneration: iron deposition in putamen correlates with the slit-like void signal of magnetic resonance imaging. (7533048)
1994
34
Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease. (8498828)
1993
35
Increased iron content in the putamen of patients with striatonigral degeneration. (1414283)
1992
36
Catecholaminergic systems in the medulla oblongata in parkinsonian syndromes: a quantitative immunohistochemical study in Parkinson's disease, progressive supranuclear palsy, and striatonigral degeneration. (1978260)
1990
37
Striatonigral degeneration. A clinicopathological study. (2276046)
1990
38
Striatonigral degeneration: clinical, MRI, and pathologic correlation. (2320250)
1990
39
Met-enkephalin immunoreactivity in the basal ganglia in Parkinson's disease and striatonigral degeneration. (2192300)
1990
40
Inhomogeneity of the putaminal lesion in striatonigral degeneration. (1975151)
1990
41
Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration. (2557795)
1989
42
Decreased glucose utilization in the striatum and frontal lobe in probable striatonigral degeneration. (2789014)
1989
43
Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). (2559165)
1989
44
Neuroleptic malignant syndrome in striatonigral degeneration. (3255444)
1988
45
Bromocriptine therapy in striatonigral degeneration. (3379440)
1988
46
Striatonigral degeneration combined with Alzheimer's disease. (6114611)
1981
47
Striatonigral degeneration disputed in familial disorder. (557771)
1977
48
Autosomal dominant striatonigral degeneration: a clinical, pathological, and biochemical study of a new genetic disorder. (1028273)
1976
49
Levodopa therapy in striatonigral degeneration. (4116273)
1972
50
Striatonigral degeneration. Clinical-pathological correlations and response to stereotaxic surgery. (4920208)
1970

Variations for Striatonigral Degeneration

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Expression for genes affiliated with Striatonigral Degeneration

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Search GEO for disease gene expression data for Striatonigral Degeneration.

Pathways for genes affiliated with Striatonigral Degeneration

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GO Terms for genes affiliated with Striatonigral Degeneration

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Cellular components related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:00431979.3DRD2, STRN
2intracellular membrane-bounded organelleGO:00432319.1ATP2B3, NUP62, SNCA
3nonmotile primary ciliumGO:00315138.9DRD1, DRD2
4axon terminusGO:00436798.8DRD1, DRD2, SNCA
5ciliary membraneGO:00601708.7DRD1, DRD2

Biological processes related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:00140599.8DRD2, SNCA
2protein import into nucleusGO:00066069.8DRD1, NUP62
3long-term synaptic potentiationGO:00602919.7DRD1, SNCA
4positive regulation of release of sequestered calcium ion into cytosolGO:00512819.7DRD1, SNCA
5response to nicotineGO:00350949.5DRD1, DRD2
6grooming behaviorGO:00076259.5DRD1, DRD2
7orbitofrontal cortex developmentGO:00217699.5DRD1, DRD2
8temperature homeostasisGO:00016599.5DRD1, DRD2
9cerebral cortex GABAergic interneuron migrationGO:00218539.5DRD1, DRD2
10peristalsisGO:00304329.5DRD1, DRD2
11feeding behaviorGO:00076319.4DRD1, DRD2
12synapse assemblyGO:00074169.4DRD1, DRD2
13negative regulation of cell migrationGO:00303369.4DRD1, DRD2
14negative regulation of circadian sleep/wake cycle, sleepGO:00423219.4DRD1, DRD2
15adult walking behaviorGO:00076289.4DRD1, DRD2
16positive regulation of long-term synaptic potentiationGO:19002739.4DRD1, DRD2
17striatum developmentGO:00217569.4DRD1, DRD2
18regulation of dopamine uptake involved in synaptic transmissionGO:00515849.4DRD1, DRD2
19negative regulation of cell proliferationGO:00082859.4DRD2, NUP62, STRN
20visual learningGO:00085429.3DRD1, DRD2
21response to morphineGO:00432789.3DRD1, DRD2
22prepulse inhibitionGO:00601349.3DRD1, DRD2
23dopamine receptor signaling pathwayGO:00072129.3DRD1, DRD2
24phospholipase C-activating dopamine receptor signaling pathwayGO:00601589.1DRD1, DRD2
25associative learningGO:00083069.0DRD1, DRD2
26regulation of long-term neuronal synaptic plasticityGO:00481699.0DRD1, DRD2, SNCA
27response to drugGO:00424938.9DRD1, DRD2, SNCA
28behavioral response to cocaineGO:00481488.8DRD1, DRD2, SNCA
29locomotory behaviorGO:00076268.7DRD1, DRD2, STRN
30response to amphetamineGO:00019758.7DRD1, DRD2
31dopamine metabolic processGO:00424178.7DRD1, DRD2, SNCA
32synaptic transmission, dopaminergicGO:00019638.6DRD1, DRD2, SNCA
33response to cocaineGO:00422208.5DRD1, DRD2, SNCA

Molecular functions related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:00055439.9NUP62, SNCA
2kinesin bindingGO:00198949.9NUP62, SNCA
3drug bindingGO:00081449.1DRD1, DRD2
4dopamine bindingGO:00352409.0DRD1, DRD2
5dopamine neurotransmitter receptor activityGO:00049528.7DRD1, DRD2

Sources for Striatonigral Degeneration

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet