MCID: STR001
MIFTS: 27

Striatonigral Degeneration malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Striatonigral Degeneration

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Aliases & Descriptions for Striatonigral Degeneration:

Name: Striatonigral Degeneration 11 49 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:4751
ICD1030 G23.2
SNOMED-CT62 29618004
MeSH39 D020955

Summaries for Striatonigral Degeneration

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NINDS:49 Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.

MalaCards based summary: Striatonigral Degeneration is related to striatonigral degeneration, infantile and striatonigral degeneration, childhood-onset. An important gene associated with Striatonigral Degeneration is NUP62 (Nucleoporin 62). Affiliated tissues include brain, cerebellum and medulla oblongata.

Wikipedia:71 Multiple system atrophy (MSA) is a degenerativeneurological disorder that depicts a group of disorders... more...

Related Diseases for Striatonigral Degeneration

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Graphical network of the top 20 diseases related to Striatonigral Degeneration:



Diseases related to striatonigral degeneration

Symptoms & Phenotypes for Striatonigral Degeneration

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Drugs & Therapeutics for Striatonigral Degeneration

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Fipamezole in Neurogenic Orthostatic HypotensionUnknown statusNCT00758849Phase 2

Search NIH Clinical Center for Striatonigral Degeneration


Cochrane evidence based reviews: striatonigral degeneration

Genetic Tests for Striatonigral Degeneration

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Anatomical Context for Striatonigral Degeneration

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MalaCards organs/tissues related to Striatonigral Degeneration:

36
Brain, Cerebellum, Medulla oblongata

Publications for Striatonigral Degeneration

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Articles related to Striatonigral Degeneration:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic Acid into the striatum. (25408589)
2014
2
Intrastriatal injection of colchicine induces striatonigral degeneration in mice. (18564367)
2008
3
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). (15583958)
2005
4
Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy). (15549330)
2005
5
Effects of riluzole on combined MPTP + 3-nitropropionic acid-induced mild to moderate striatonigral degeneration in mice. (15503195)
2005
6
MPTP potentiates 3-nitropropionic acid-induced striatal damage in mice: reference to striatonigral degeneration. (14697318)
2004
7
Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy). (15056471)
2004
8
Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration. (15372496)
2004
9
Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy). (12764627)
2003
10
Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic Parkinson's disease from those with striatonigral degeneration. (12242540)
2002
11
Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys. (12457736)
2002
12
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration. (11935266)
2002
13
A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis. (12421620)
2002
14
A novel grading scale for striatonigral degeneration (multiple system atrophy). (11956953)
2002
15
Thin section MR study of the basal ganglia in the differential diagnosis between striatonigral degeneration and Parkinson disease. (11884785)
2002
16
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy). (11226695)
2001
17
Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: a model of early-stage striatonigral degeneration. (11161601)
2001
18
FLAIR MRI of striatonigral degeneration. (11342686)
2001
19
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesencephalic, striatal or co-grafts. (10658617)
2000
20
Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy). (10924951)
2000
21
An early description of striatonigral degeneration. (10836627)
2000
22
Neuropsychological follow up in patients with Parkinson's disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy. (10945805)
2000
23
In vivo magnetic resonance imaging of embryonic neural grafts in a rat model of striatonigral degeneration (multiple system atrophy). (10913326)
2000
24
Striatonigral degeneration with motor neuron disease. (10896276)
2000
25
Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy). (10877927)
2000
26
Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration. (10661519)
2000
27
Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration. (10830420)
2000
28
Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson's disease. (10896267)
2000
29
An early description of striatonigral degeneration. (10431772)
1999
30
Increased basal ganglia iron in striatonigral degeneration: in vivo estimation with magnetic resonance. (9532280)
1998
31
Cortical and brain stem hyperexcitability in striatonigral degeneration. (9613764)
1998
32
Differentiation of idiopathic Parkinson's disease from striatonigral degeneration and progressive supranuclear palsy using iodine-123 meta-iodobenzylguanidine myocardial scintigraphy. (9562324)
1998
33
Correlative studies of MR findings with neuropathology in Shy-Drager syndrome and striatonigral degeneration. (9594269)
1997
34
MRI in sporadic olivopontocerebellar atrophy and striatonigral degeneration. (9065575)
1997
35
Medial pallidotomy in late-stage Parkinson's disease and striatonigral degeneration. (9348415)
1997
36
Urinary disturbances in striatonigral degeneration and Parkinson's disease: clinical and urodynamic aspects. (9251068)
1997
37
Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration. (8857740)
1996
38
Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration. (8866493)
1996
39
Pure" striatonigral degeneration and Parkinson's disease: a comparative clinical study. (7651445)
1995
40
Neuropsychological pattern of striatonigral degeneration: comparison with Parkinson's disease and progressive supranuclear palsy. (7876847)
1995
41
Striatal opioid receptor binding in Parkinson's disease, striatonigral degeneration and Steele-Richardson-Olszewski syndrome, A [11C]diprenorphine PET study. (7655890)
1995
42
Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state. (7550604)
1995
43
Neuroleptic malignant syndrome in striatonigral degeneration. (8554665)
1995
44
Striatonigral degeneration: iron deposition in putamen correlates with the slit-like void signal of magnetic resonance imaging. (7533048)
1994
45
Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson's disease. (8498828)
1993
46
Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study. (8505636)
1993
47
Striatonigral degeneration with neurofibrillary tangles. (8256593)
1993
48
Increased iron content in the putamen of patients with striatonigral degeneration. (1414283)
1992
49
Striatal D2 receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with 11C-raclopride and positron emission tomography. (1575457)
1992
50
Neuropsychological deficits accompanying striatonigral degeneration. (1955531)
1991

Variations for Striatonigral Degeneration

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Expression for genes affiliated with Striatonigral Degeneration

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Search GEO for disease gene expression data for Striatonigral Degeneration.

Pathways for genes affiliated with Striatonigral Degeneration

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GO Terms for genes affiliated with Striatonigral Degeneration

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Cellular components related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axon terminusGO:004367910.2DRD2, SNCA
2intracellular membrane-bounded organelleGO:00432319.0ATP2B3, NUP62, SNCA

Biological processes related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1behavioral response to cocaineGO:004814810.0DRD2, SNCA
2dopamine metabolic processGO:004241710.0DRD2, SNCA
3regulation of dopamine secretionGO:001405910.0DRD2, SNCA
4regulation of long-term neuronal synaptic plasticityGO:004816910.0DRD2, SNCA
5response to cocaineGO:00422209.8DRD2, SNCA
6synaptic transmission, dopaminergicGO:00019639.5DRD2, SNCA

Molecular functions related to Striatonigral Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinesin bindingGO:001989410.1NUP62, SNCA
2phospholipid bindingGO:00055439.6NUP62, SNCA

Sources for Striatonigral Degeneration

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet