MCID: STR080
MIFTS: 23

Stroke, Hemorrhagic malady

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Summaries for Stroke, Hemorrhagic

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MalaCards based summary: Stroke, Hemorrhagic, also known as haemorrhagic stroke, is related to hemorrhage, intracerebral and cerebritis. An important gene associated with Stroke, Hemorrhagic is ACE (angiotensin I converting enzyme), and among its related pathways are Pathways in cancer and Focal adhesion. The compound arresten have been mentioned in the context of this disorder. Related mouse phenotypes are other and cardiovascular system.

Description from OMIM:46 614519

Aliases & Classifications for Stroke, Hemorrhagic

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Stroke, Hemorrhagic, Aliases & Descriptions:

Name: Stroke, Hemorrhagic 46
Haemorrhagic Stroke 62
 
Hemorrhagic Stroke 44


Related Diseases for Stroke, Hemorrhagic

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Graphical network of the top 20 diseases related to Stroke, Hemorrhagic:



Diseases related to stroke, hemorrhagic

Symptoms for Stroke, Hemorrhagic

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Clinical features from OMIM:

614519

Drugs & Therapeutics for Stroke, Hemorrhagic

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Drug clinical trials:

Search ClinicalTrials for Stroke, Hemorrhagic

Search NIH Clinical Center for Stroke, Hemorrhagic

Genetic Tests for Stroke, Hemorrhagic

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Anatomical Context for Stroke, Hemorrhagic

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Animal Models for Stroke, Hemorrhagic or affiliated genes

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MGI Mouse Phenotypes related to Stroke, Hemorrhagic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.2COL4A1, COL4A2
2MP:00053858.6COL4A1, COL4A2, ACE
3MP:00053978.5COL4A1, COL4A2, ACE
4MP:00053768.5COL4A1, COL4A2, ACE
5MP:00053848.4ACE, COL4A2, COL4A1
6MP:00053788.2COL4A1, COL4A2, ACE

Publications for Stroke, Hemorrhagic

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Variations for Stroke, Hemorrhagic

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Clinvar genetic disease variations for Stroke, Hemorrhagic:

6
id Gene Name Type Significance SNP ID Assembly Location
1COL4A2NM_001846.2(COL4A2): c.3368A> G (p.Glu1123Gly)single nucleotide variantrisk factorrs117412802GRCh37Chr 13, 111143601: 111143601
2COL4A2NM_001846.2(COL4A2): c.3448C> A (p.Gln1150Lys)single nucleotide variantrisk factorrs62621875GRCh37Chr 13, 111143681: 111143681
3COL4A2NM_001846.2(COL4A2): c.5068G> A (p.Ala1690Thr)single nucleotide variantrisk factorrs201105747GRCh37Chr 13, 111164467: 111164467
4COL4A1NM_001845.4(COL4A1): c.1055C> T (p.Pro352Leu)single nucleotide variantrisk factorrs200786329GRCh37Chr 13, 110853814: 110853814
5COL4A1NM_001845.4(COL4A1): c.1612C> G (p.Arg538Gly)single nucleotide variantrisk factorrs397514624GRCh37Chr 13, 110839601: 110839601

Expression for genes affiliated with Stroke, Hemorrhagic

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Expression patterns in normal tissues for genes affiliated with Stroke, Hemorrhagic

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Pathways for genes affiliated with Stroke, Hemorrhagic

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Pathways related to Stroke, Hemorrhagic according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1COL4A1, COL4A2
2
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.1COL4A2, COL4A1
3
Show member pathways
9.1COL4A1, COL4A2
4
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.1COL4A1, COL4A2
59.1COL4A2, COL4A1
6
Show member pathways
9.1COL4A1, COL4A2
7
Show member pathways
9.1COL4A1, COL4A2
8
Show member pathways
9.1COL4A1, COL4A2
9
Show member pathways
9.1COL4A1, COL4A2
10
Show member pathways
9.1COL4A2, COL4A1
119.1COL4A1, COL4A2
12
Show member pathways
9.1COL4A1, COL4A2
139.1COL4A2, COL4A1
149.1COL4A2, COL4A1
15
Show member pathways
9.1COL4A1, COL4A2
169.1COL4A2, COL4A1
17
Show member pathways
9.1COL4A2, COL4A1
189.1COL4A1, COL4A2
199.1COL4A1, COL4A2
209.1COL4A1, COL4A2

Compounds for genes affiliated with Stroke, Hemorrhagic

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Sources:
44Novoseek
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Compounds related to Stroke, Hemorrhagic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arresten449.1COL4A1, COL4A2

GO Terms for genes affiliated with Stroke, Hemorrhagic

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Cellular components related to Stroke, Hemorrhagic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IVGO:0055879.1COL4A1, COL4A2
2endoplasmic reticulum lumenGO:0057889.1COL4A1, COL4A2
3extracellular matrixGO:0310128.8COL4A1, COL4A2
4extracellular regionGO:0055768.4COL4A1, COL4A2, ACE

Biological processes related to Stroke, Hemorrhagic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:0305749.1COL4A1, COL4A2
2axon guidanceGO:0074119.1COL4A1, COL4A2
3extracellular matrix disassemblyGO:0226179.0COL4A1, COL4A2
4extracellular matrix organizationGO:0301988.8COL4A1, COL4A2

Molecular functions related to Stroke, Hemorrhagic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.1COL4A1, COL4A2

Products for genes affiliated with Stroke, Hemorrhagic

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Sources for Stroke, Hemorrhagic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet