MCID: STR067
MIFTS: 72

Stroke, Ischemic

Categories: Genetic diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Stroke, Ischemic

MalaCards integrated aliases for Stroke, Ischemic:

Name: Stroke, Ischemic 54 39 38
Cerebral Infarction 54 39 12 71 52 42 14 69
Stroke 54 51 29 52 41 3
Ischemic Stroke 54 71 29 41 69
Cerebrovascular Accident 39 71 69
Cerebral Infarction, Susceptibility to 13
Ischemic Cerebrovascular Accident 69
Cva - Cerebral Infarction 12
Cerebral Infarction Nos 12
Cerebral Infarct 12
Ischstr 71

Characteristics:

OMIM:

54
Inheritance:
multifactorial predisposition


Classifications:



Summaries for Stroke, Ischemic

MedlinePlus : 41 a stroke is a medical emergency. strokes happen when blood flow to your brain stops. within minutes, brain cells begin to die. there are two kinds of stroke. the more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. the other kind, called hemorrhagic stroke, is caused by a blood vessel that breaks and bleeds into the brain. "mini-strokes" or transient ischemic attacks (tias), occur when the blood supply to the brain is briefly interrupted. symptoms of stroke are sudden numbness or weakness of the face, arm or leg (especially on one side of the body) sudden confusion, trouble speaking or understanding speech sudden trouble seeing in one or both eyes sudden trouble walking, dizziness, loss of balance or coordination sudden severe headache with no known cause if you have any of these symptoms, you must get to a hospital quickly to begin treatment. acute stroke therapies try to stop a stroke while it is happening by quickly dissolving the blood clot or by stopping the bleeding. post-stroke rehabilitation helps individuals overcome disabilities that result from stroke damage. drug therapy with blood thinners is the most common treatment for stroke. nih: national institute of neurological disorders and stroke

MalaCards based summary : Stroke, Ischemic, also known as cerebral infarction, is related to myocardial infarction and ischemic heart disease, and has symptoms including stroke, angina pectoris and back pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Valsartan and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Umbilical Cord, and related phenotypes are homeostasis/metabolism and cardiovascular system

UniProtKB/Swiss-Prot : 71 Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

CDC : 3 Stroke is the fifth leading cause of death in the United States and is a major cause of serious disability for adults.1,2 About 795,000 people in the United States have a stroke each year.2Get more quick facts about stroke.

NINDS : 51 A stroke occurs when the blood supply to part of the brain is suddenly interrupted or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells. Brain cells die when they no longer receive oxygen and nutrients from the blood or there is sudden bleeding into or around the brain. The symptoms of a stroke include sudden numbness or weakness, especially on one side of the body; sudden confusion or trouble speaking or understanding speech; sudden trouble seeing in one or both eyes; sudden trouble with walking, dizziness, or loss of balance or coordination; or sudden severe headache with no known cause. There are two forms of stroke: ischemic - blockage of a blood vessel supplying the brain, and hemorrhagic - bleeding into or around the brain.

OMIM : 54
A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. It is said to be the third leading cause of death in the United States. Gunel and Lifton (1996) noted that about 20% of strokes are hemorrhagic, resulting in bleeding into the brain. Ischemic strokes, resulting from vascular occlusion, account for the majority of strokes. Bersano et al. (2008) reviewed genetic polymorphisms that have been implicated in the development of stroke. Candidate genes include those involved in hemostasis (see, e.g., F5; 612309), the renin-angiotensin-aldosterone system (see, e.g., ACE; 106180), homocysteine (see, e.g., MTHFR; 607093), and lipoprotein metabolism (see, e.g., APOE; 107741). See also hemorrhagic stroke, or intracerebral hemorrhage (ICH; 614519). (601367)

Related Diseases for Stroke, Ischemic

Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 30.9 ACE ALOX5AP F2 F3 F5 MTHFR
2 ischemic heart disease 30.5 ACE APOH F2 SELP SERPINC1 SERPINE1
3 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 12.3
4 pediatric arterial ischemic stroke 12.2
5 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 12.0
6 sneddon syndrome 11.9
7 cerebrovascular disease 11.4
8 neonatal stroke 11.3
9 intracranial embolism 11.2
10 mcgillivray syndrome 11.2 APOH F5
11 multicentric osteolysis nephropathy 11.2 F5 MTHFR
12 variably protease-sensitive prionopathy 11.2 F2 F5
13 primary pigmented nodular adrenocortical disease 11.2 F2 F5 MTHFR
14 coronary sinus stenosis 11.2 F5 MTHFR SERPINE1
15 amelogenesis imperfecta hypomaturation type 11.2 F5 MTHFR SERPINE1
16 aortopulmonary window 11.2 ACE FBN1 NOS3
17 pregnancy loss, recurrent 1 11.2 APOH F5 MTHFR
18 argyria 11.1 ACE F2
19 egg allergy 11.1 F2 PLAT SERPINC1
20 accessory deep peroneal nerve 11.1 APOH F5
21 stoll alembik finck syndrome 11.1 F5 SERPINC1 SERPINE1
22 pyridoxine deficiency anemia 11.1 F2 F3 SERPINC1
23 fragile x syndrome type 2 11.1 F2 F3 SERPINC1
24 factor v deficiency 11.1 F2 F3 F5
25 conjunctival disease 11.1 ACE PLAT SERPINC1
26 brain ischemia 11.1
27 islet cell tumor 11.1 ACE MTHFR NOS3
28 unna-thost palmoplantar keratoderma 11.1 THBD VWF
29 myiasis 11.1 F2 F3 SERPINC1
30 inferolateral myocardial infarct 11.1 F2 SERPINC1 SERPINE1
31 rectum neuroendocrine neoplasm 11.1 F2 F3 SERPINC1
32 venezuelan hemorrhagic fever 11.1 PLAT SERPINC1 SERPINE1
33 superior limbic keratoconjunctivitis 11.1 F2 F5 MTHFR SERPINC1
34 homologous wasting disease 11.1 F2 F5 FBN1 MTHFR
35 moderately severe hemophilia b 11.1 F2 F3 F5
36 follicular adenoma 11.1 F2 F5 MTHFR SERPINC1
37 von willibrand disease, type 3 11.1 F2 F3 VWF
38 glutathioninuria 11.1 APOH F2 F5 SERPINC1
39 46,xy ovotesticular disorder of sex development 11.1 APOH F2 F3 F5
40 lethal congenital contracture syndrome 11.1 F2 F3 SERPINC1
41 primary hyperoxaluria 11.1 ACE SERPINC1
42 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 11.1 F5 SELP SERPINE1
43 hyperthyroidism 11.1 F2 F3
44 hereditary amyloidosis 11.1 F3 SELP SERPINC1
45 pyelonephritis 11.1 ACE F2 NOS3 SERPINC1
46 testicular gonadoblastoma 11.1 F2 F3 F5 SERPINC1
47 mechanical entropion 11.1 NOS3 PLAT
48 hepadnavirus infection 11.1 F2 F3 SERPINC1
49 cataract, autosomal dominant congenital 4 11.1 ACE SERPINE1 VWF
50 thoracic spinal canal and spinal cord meningioma 11.1 ACE FBN1 NOS3

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to Stroke, Ischemic

Symptoms & Phenotypes for Stroke, Ischemic

Symptoms via clinical synopsis from OMIM:

54

Neuro:
stroke
motor, sensory and/or cognitive function loss


Clinical features from OMIM:

601367

Human phenotypes related to Stroke, Ischemic:

32
id Description HPO Frequency HPO Source Accession
1 stroke 32 HP:0001297

UMLS symptoms related to Stroke, Ischemic:


angina pectoris, back pain, chest pain, edema, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, equilibration disorder, sleeplessness

MGI Mouse Phenotypes related to Stroke, Ischemic:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.43 SELP SERPINC1 SERPINE1 THBD VWF ACE
2 cardiovascular system MP:0005385 10.37 ACE F2 F3 F5 FBN1 NOS3
3 hematopoietic system MP:0005397 10.34 SELP SERPINC1 SERPINE1 THBD VWF ACE
4 growth/size/body region MP:0005378 10.32 ACE F2 F3 F5 FBN1 MTHFR
5 immune system MP:0005387 10.3 PLAT PRKCH SELP SERPINC1 SERPINE1 THBD
6 mortality/aging MP:0010768 10.27 ACE APOH F2 F3 F5 FBN1
7 integument MP:0010771 10.13 FBN1 MTHFR NOTCH3 PRKCH SELP SERPINE1
8 nervous system MP:0003631 10.1 SERPINC1 THBD VWF F2 F3 F5
9 liver/biliary system MP:0005370 9.95 ACE F5 NOS3 SELP SERPINC1 SERPINE1
10 renal/urinary system MP:0005367 9.91 ACE FBN1 NOS3 NOTCH3 PTGIS SELP
11 reproductive system MP:0005389 9.81 ACE F2 FBN1 MTHFR NOS3 NOTCH3
12 respiratory system MP:0005388 9.61 F2 F3 FBN1 NOS3 NOTCH3 PLAT
13 vision/eye MP:0005391 9.23 F3 MTHFR NOS3 NOTCH3 PLAT PRKCH

Drugs & Therapeutics for Stroke, Ischemic

Drugs for Stroke, Ischemic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 598)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
2
Benzocaine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
3
Zinc Approved Phase 4,Phase 2,Phase 3,Phase 1 7440-66-6 32051 23994
4
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
5 Nadroparin Approved Phase 4 9041-08-1
6
Atenolol Approved Phase 4 29122-68-7 2249
7
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-78-2 2244
8
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
9
Nimodipine Approved Phase 4 66085-59-4 4497
10
Colchicine Approved Phase 4,Phase 3 64-86-8 6167 2833
11
Nicardipine Approved Phase 4,Phase 3 55985-32-5 4474
12
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
13
Rivaroxaban Approved Phase 4,Phase 2,Phase 3 366789-02-8
14
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1 274693-27-5 9871419
15
Warfarin Approved Phase 4,Phase 3,Phase 2,Phase 1 81-81-2 6691 54678486
16
Phenprocoumon Approved Phase 4,Phase 3 435-97-2 9908 54680692
17
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55142-85-3 5472
18
Candesartan Approved Phase 4 139481-59-7 2541
19
Abciximab Approved Phase 4,Phase 3,Phase 2 143653-53-6
20
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
21
Cilostazol Approved Phase 4,Phase 3 73963-72-1 2754
22
Dalteparin Approved Phase 4,Phase 3,Phase 2 9005-49-6
23
Antipyrine Approved Phase 4,Phase 3,Phase 2,Phase 1 60-80-0 2206
24
Everolimus Approved Phase 4,Phase 2,Phase 3 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3 53123-88-9 5284616 6436030 46835353
27
Apixaban Approved Phase 4,Phase 2,Phase 3 503612-47-3 10182969
28 Edoxaban Approved Phase 4,Phase 2,Phase 3 480449-70-5
29
Dopamine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 51-61-6, 62-31-7 681
30
Acenocoumarol Approved Phase 4,Phase 3 152-72-7 9052 54676537
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
32
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
33
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192
34
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
35
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
36
Glyburide Approved Phase 4,Phase 2,Phase 1 10238-21-8 3488
37 Piracetam Approved Phase 4 7491-74-9
38
Losartan Approved Phase 4,Phase 3 114798-26-4 3961
39
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 75614-87-8, 51-45-6 774
40
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 74863-84-6 152951
41
Thrombin Approved Phase 4,Phase 3,Phase 1,Phase 2
42
Dipyridamole Approved Phase 4,Phase 3,Phase 2 58-32-2 3108
43
Saxagliptin Approved Phase 4 361442-04-8 11243969
44
Triflusal Approved Phase 4 322-79-2
45
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
46
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
47 Racepinephrine Approved Phase 4,Phase 2
48
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
49
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
50
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3 33069-62-4 36314

Interventional clinical trials:

(show top 50) (show all 1502)

id Name Status NCT ID Phase Drugs
1 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
2 Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke Unknown status NCT00874601 Phase 4 Diovan® (valsartan)
3 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
4 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4 Intensive insulin therapy
5 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
6 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
7 Multi-"Omics" Research of Danhong Injection to Treat Acute Ischemic Stroke Unknown status NCT02176395 Phase 4 Danhong injection;placebo
8 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
9 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
10 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
11 Safety Study of Melatonin in Stroke Patients Unknown status NCT01863277 Phase 4 Melatonin;placebo
12 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4 Nimodipine;Placebo
13 Colchicine for Acute Coronary Syndromes Unknown status NCT01906749 Phase 4 Colchicine;Placebo
14 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
15 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4 Nicardipine
16 Aliskiren or Amlodipine in Hypertensive Hemodialysed Patients Unknown status NCT01394770 Phase 4 Aliskiren
17 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
18 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
19 Resuvastatin Treatment for Symptomatic Middle Cerebral Artery Stenosis Based on High-resolution Magnetic Resonance Imaging Unknown status NCT02041117 Phase 4 Rosuvastatin
20 Nimodipine for Treating Acute Massive Cerebral Infarction Unknown status NCT02248233 Phase 4 Nimodipine;Saline + citicoline
21 Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation Unknown status NCT00776633 Phase 4 aspirin;clopidogrel;oral anticoagulation
22 Acute Candesartan Cilexetil Outcomes Stroke Trial (ACCOST) Unknown status NCT00108706 Phase 4 Candesartan
23 Bivalirudin/Prasugrel Versus Abciximab/Clopidogrel in Patients Presenting With STEMI Unknown status NCT01158846 Phase 4 prasugrel/bivalirudin;clopidogrel/abciximab
24 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
25 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO) Completed NCT01088672 Phase 4
26 Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke Completed NCT00478478 Phase 4
27 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
28 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
29 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Completed NCT01958957 Phase 4 Ginkgolides Meglumine Injection
30 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
31 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
32 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
33 The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED) Completed NCT00754429 Phase 4 losartan;amlodipine
34 The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke Completed NCT00868283 Phase 4 Cerebrolysin;0.9% Saline Solution
35 PREVAIL: PREvention of VTE After Acute Ischemic Stroke With LMWH Enoxaparin ( - VTE: Venous Thromboembolism - LMWH: Low Molecular Weight Heparin) Completed NCT00077805 Phase 4 Enoxaparin sodium
36 Quality Improvement in Stroke Prevention (QUISP) Completed NCT00328640 Phase 4 Optimal treatment
37 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
38 Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke Completed NCT01109836 Phase 4
39 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
40 AISTCM-Outcome Measurement of Acute Ischemic Stroke With Traditional Chinese Medicine Completed NCT00351806 Phase 4 Erigeron breviscapus injection;hua tuo zai zao wan (a herbal medicine pill);Compound stroke herbal medicine (8 herbal)
41 Edaravone-Sodium Ozagrel Comparative Post-Marketing Study on Acute Ischemic Stroke Completed NCT00200356 Phase 4 Edaravone;Sodium Ozagrel
42 The Secondary Prevention Trial for Ischemic Stroke With DengzhanShengmai Capsule Completed NCT00548223 Phase 4 Dengzhan Shengmai capsule;placebo
43 Edaravone and Argatroban Stroke Therapy Study for Acute Ischemic Stroke Completed NCT00153946 Phase 4 Edaravone
44 EARLY 3-months Aggrenox Treatment Started Within 24 Hrs of Ischemic Stroke Onset vs. After One Week 100 mg ASA Completed NCT00562588 Phase 4 Aggrenox bid (ASA 25mg/Dipyridamole ER 200mg);ASA 100 mg qd
45 Does Saxagliptin Reduce the Risk of Cardiovascular Events When Used Alone or Added to Other Diabetes Medications Completed NCT01107886 Phase 4 Saxagliptin;Placebo
46 Patent Foramen Ovale in Cryptogenic Stroke Study Completed NCT00697151 Phase 4 Warfarin;Aspirin
47 Aspirin Versus Aspirin + ClopidogRel Following Transcatheter Aortic Valve Implantation: the ARTE Trial Completed NCT01559298 Phase 4 Aspirin (80 mg/d) + clopidogrel (75 mg/d);Aspirin
48 Preliminary Study of Pharmacokinetics of Ginkgolides Meglumine Injection. Completed NCT02046031 Phase 4 Ginkgolides Meglumine Injection
49 Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke Completed NCT00924638 Phase 4
50 Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping Completed NCT01174693 Phase 4 Triflusal;Clopidogrel

Search NIH Clinical Center for Stroke, Ischemic

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Cerecellgram-Stroke, bone marrow-derived mesenchymal stem cells for treatment of ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905
Bone marrow-derived mononuclear cells (family) PMIDs: 22960888
Bone marrow-derived mononuclear cells PMIDs: 17635049
Bone marrow-derived mononuclear cells PMIDs: 20629187 20395386
Bone marrow-derived mesenchymal stem cells (Cerecellgram-Stroke)
Neural stem cells PMIDs: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285
Fetal spinal cord stem cells (NSI-566) PMIDs: 22415942 19326469
Olfactory ensheathing cells
Placenta-derived cells
Neural stem cell line (CTX0E03) PMIDs: 19633272 23185625 17981710
Notch-transfected mesenchymal stromal cells (SB623) PMIDs: 19530164 23430693 20350349 21982515
Trophic factor-induced mesenchymal stem cells PMIDs: 19530164 23430693 20350349 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne PMIDs: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Cochrane evidence based reviews: cerebral infarction

Genetic Tests for Stroke, Ischemic

Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke 29
2 Stroke 29

Anatomical Context for Stroke, Ischemic

MalaCards organs/tissues related to Stroke, Ischemic:

39
Brain, Heart, Bone, Endothelial, Eye, Bone Marrow, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells

Publications for Stroke, Ischemic

Articles related to Stroke, Ischemic:

id Title Authors Year
1
Associations between hematopoietic growth factors and risks of venous thromboembolism, stroke, ischemic heart disease and myelodysplastic syndrome: findings from a large population-based cohort of women with breast cancer. ( 27059219 )
2016
2
Glycated hemoglobin and risk of stroke, ischemic and hemorrhagic, in Japanese men and women. ( 18667812 )
2008

Variations for Stroke, Ischemic

ClinVar genetic disease variations for Stroke, Ischemic:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 F5 NM_000130.4(F5): c.1601G> A (p.Arg534Gln) single nucleotide variant risk factor rs6025 GRCh37 Chromosome 1, 169519049: 169519049
2 F2 NM_000506.4(F2): c.*97G> A single nucleotide variant Pathogenic,risk factor rs1799963 GRCh37 Chromosome 11, 46761055: 46761055
3 NOS3 NM_000603.4(NOS3): c.894T> G (p.Asp298Glu) single nucleotide variant risk factor rs1799983 GRCh37 Chromosome 7, 150696111: 150696111
4 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893
5 FBN1 NM_000138.4(FBN1): c.5788+5G> A single nucleotide variant Pathogenic rs193922219 GRCh37 Chromosome 15, 48738898: 48738898

Copy number variations for Stroke, Ischemic from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 135006 2 110200000 114400000 Amplification IL1RN Ischaemic stroke

Expression for Stroke, Ischemic

LifeMap Discovery
Genes differentially expressed in tissues of Stroke, Ischemic patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ARG1 arginase 1 Blood + 11.63 0.000
Search GEO for disease gene expression data for Stroke, Ischemic.

Pathways for Stroke, Ischemic

GO Terms for Stroke, Ischemic

Cellular components related to Stroke, Ischemic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ACE APOH F2 F3 F5 FBN1
2 platelet alpha granule lumen GO:0