MCID: STR067
MIFTS: 74

Stroke, Ischemic malady

Cardiovascular diseases category

Summaries for Stroke, Ischemic

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46OMIM, 32MalaCards
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MalaCards: Stroke, Ischemic, also known as cerebral infarction, is related to hypertension and atherosclerosis. An important gene associated with Stroke, Ischemic is F2 (coagulation factor II (thrombin)), and among its related pathways are PEDF Induced Signaling and Thromboxane A2 receptor signaling. The drugs heparin and heparin sodium and the compounds monoethylglycinexylidide and inogatran have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and heart, and related mouse phenotype mortality/aging.

Description from OMIM:46 601367

Aliases & Classifications for Stroke, Ischemic

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Sources:
32MalaCards, 22GTR, 46OMIM, 30LifeMap Discovery™, 8Disease Ontology, 44Novoseek, 60UMLS, 10DISEASES, 9diseasecard, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Stroke, Ischemic

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17GeneCards, 18GeneDecks
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Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 384)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.7NOS3, F2, F5
2atherosclerosis30.6NOS3
3protein c deficiency30.5F5, F2
4diabetes mellitus30.5NOS3, HBA1
5sickle cell anemia30.4HBA1
6hemorrhagic disease30.4F2, F5
7vasculitis30.3F2
8essential hypertension30.3NOS3
9rheumatoid arthritis30.3PRKCH
10antiphospholipid syndrome30.3F2, F5
11sickle cell disease30.2NOS3
12intracranial aneurysm30.2NOS3
13patent foramen ovale30.1F5
14vascular disease30.1HBA1
15ovarian hyperstimulation syndrome30.1F5
16retinal vein occlusion30.1F5
17thrombocytosis30.1F2
18antithrombin iii deficiency30.1F5, F2
19hepatitis a30.1F2
20pulmonary embolism30.1F2, F5
21disseminated intravascular coagulation30.1F5, F2
22deficiency anemia30.1HBA1, F2
23hyperhomocysteinemia30.1NOS3, F2, F5
24prothrombin deficiency29.9F2, F5
25factor xi deficiency29.9F5, F2
26factor vii deficiency29.9F5, F2
27factor viii deficiency29.9F5, F2
28diabetic retinopathy29.9NOS3, HBA1
29hepatocellular carcinoma29.9F2
30obesity29.8NOS3
31thrombophilia29.8F5, F2
32factor v deficiency29.8F2, F5
33portal vein thrombosis29.8F5, F2
34cadasil29.8NOS3, F2, F5
35cerebritis11.4
36cerebrovascular disease10.7
37cerebral artery occlusion10.5
38meningitis10.5
39neuronitis10.5
40ischemia10.4
41moyamoya disease10.4
42middle cerebral artery infarction10.4
43cerebral atherosclerosis10.4
44angioedema10.4
45carotid artery dissection10.4
46carotid artery occlusion10.4
47myocardial infarction10.4
48cerebral lymphoma10.3
49migraine10.3
50peripheral vascular disease10.3

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Clinical Features for Stroke, Ischemic

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46OMIM
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Clinical features from OMIM:

601367

Clinical synopsis from OMIM:

601367

Drugs & Therapeutics for Stroke, Ischemic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stroke, Ischemic

Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Search CenterWatch for Stroke, Ischemic

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

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22GTR
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Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke22

Anatomical Context for Stroke, Ischemic

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Stroke, Ischemic:

32
Brain, Bone, Heart, Endothelial, Spinal cord, Bone marrow, Lung, Testes, T cells, Monocytes, Cortex, Thyroid, B cells, Temporal lobe, Prefrontal cortex, Myeloid, Prostate, Placenta, Liver, Adipocyte, Whole blood, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Stroke, Ischemic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5NOS3, F2, HBA1, PRKCH, F5

Publications for Stroke, Ischemic

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50PubMed
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Articles related to Stroke, Ischemic:

(show top 50)    (show all 1876)
idTitleAuthorsYear
1
Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case-Control and Prospective Cohort Studies. (24436234)
2014
2
Thrombopoietin and mean platelet volume in patients with ischemic stroke. (22327824)
2013
3
Carotid Intima Media Thickness as a Reflection of Generalized Atherosclerosis is Related to Body Mass Index in Ischemic Stroke Patients. (23626961)
2013
4
Impact of both ends of the hemoglobin range on clinical outcomes in acute ischemic stroke. (24003047)
2013
5
Supra-aortic arteries: Three-dimensional time-resolved k-t BLAST contrast-enhanced MRA using a nondedicated body coil at 3 tesla in acute ischemic stroke. (24222649)
2013
6
Corrigendum to "Medical image analysis methods in MR/CT-imaged acute-subacute ischemic stroke lesion: Segmentation, prediction and insights into dynamic evolution simulation models. A critical appraisal" [NeuroImage: Clinical 1 (2012) 164-178]. (24179810)
2013
7
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. (24008734)
2013
8
Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke. (23982710)
2013
9
Acute promyelocytic leukemia presenting as ischemic stroke in young. (24426346)
2013
10
Rate of deep-vein thrombosis and pulmonary embolism during the care continuum in patients with acute ischemic stroke in the United States. (23391151)
2013
11
Association of functional VKORC1 promoter polymorphism with occurrence and clinical aspects of ischemic stroke in a Greek population. (24288433)
2013
12
A Novel Risk Haplotype of ALOX5AP Gene is Associated with Ischemic Stroke in Chinese Han Population. (24198186)
2013
13
Stent Retrievers in Acute Ischemic Stroke: Complications and Failures during the Perioperative Period. (24157734)
2013
14
Thrombin generation in acute cardioembolic and non-cardioembolic ischemic stroke. (24063505)
2013
15
Treatment with statins and ischemic stroke severity: does the dose matter? (24297802)
2013
16
Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke. (24043255)
2013
17
Carotid ultrasound imaging in a patient with acute ischemic stroke and aortic dissection: a lesson for the management of ischemic stroke? (24267907)
2013
18
Lack of association between a functional genetic variant of connexin 37 and ischemic stroke in a Taiwanese population. (22305353)
2012
19
Impact of the -174G/C interleukin-6 (IL-6) gene polymorphism on the risk of paediatric ischemic stroke, its symptoms and outcome. (22773460)
2012
20
Lateral sinus thrombosis and haemorrhagic ischemic stroke with protein S deficiency in a young. (24047030)
2012
21
Central sleep apnea is associated with increased risk of ischemic stroke in the elderly. (22150745)
2012
22
Extracranial carotid artery disease in nasopharyngeal carcinoma patients with post-irradiation ischemic stroke. (20579803)
2010
23
Relationship between Q192R polymorphisms in paraoxonase 1 gene and young ischemic stroke]. (20646512)
2010
24
Relation between intracranial artery calcifications and aortic atherosclerosis in ischemic stroke patients. (20354715)
2010
25
C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects. (19193985)
2009
26
Lack of association between variations of PDE4D and ischemic stroke in the Japanese population. (19246712)
2009
27
Thrombolysis with alteplase for acute ischemic stroke: safe and effective outside the 3-hour time window? (19107108)
2009
28
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. (19597491)
2009
29
Meta-analysis of genetic studies from journals published in China of ischemic stroke in the Han Chinese population. (18511872)
2008
30
Empirical characteristics of litigation involving tissue plasminogen activator and ischemic stroke. (18313798)
2008
31
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations. (18323512)
2008
32
Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. (18510966)
2008
33
Carboxypeptidase U (TAFIa) activity is induced in vivo in ischemic stroke patients receiving thrombolytic therapy. (17944994)
2008
34
Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis. (17452160)
2007
35
Haplotypes of the plasminogen activator gene associated with ischemic stroke. (16953275)
2006
36
Hypothermia blocks ischemic changes in ubiquitin distribution and levels following stroke. (17047455)
2006
37
APOE genotype and serum cholesterol in predicting risk for early death from ischemic stroke in men and women. (16131797)
2005
38
Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. (15381054)
2004
39
C-reactive protein as an important prognostic marker for ischemic stroke]. (12839660)
2003
40
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. (14517540)
2003
41
Protein Z in ischemic stroke and its etiologic subtypes. (12970515)
2003
42
Von Willebrand factor, fibrinogen and other risk factors of thrombosis in patients with a history of cerebrovascular ischemic stroke and their children. (12325470)
2002
43
Predictors of fatal brain edema in massive hemispheric ischemic stroke. (11546905)
2001
44
Intravenous tPA in acute ischemic stroke related to internal carotid artery dissection. (10851384)
2000
45
Inherited thrombophilia as a risk factor for the development of ischemic stroke in young adults. (10739378)
2000
46
Low prevalence of the factor V Leiden among patients with ischemic stroke. (9097081)
1997
47
Alterations of platelet, coagulation, and fibrinolysis markers in patients with acute ischemic stroke. (9469626)
1997
48
Neuro-specific enolase in acute ischemic stroke and related dementia patients]. (9208570)
1995
49
Ischemic and hemorrhagic stroke in patients on oral anticoagulants after reconstruction for chronic lower limb ischemia. (8236338)
1993
50
Migraine without aura and ischemic stroke. (1517072)
1992

Genetic Variations for Stroke, Ischemic

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Expression for genes affiliated with Stroke, Ischemic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stroke, Ischemic

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Pathways for genes affiliated with Stroke, Ischemic

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Stroke, Ischemic

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44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide4410.4F5
2inogatran449.9F2, F5
3ecarin449.9F5, F2
4hirugen449.9F5, F2
5spectrozyme449.9F2, F5
6batroxobin449.9F5, F2
7danaparoid449.9F5, F2
8kaolin449.9F5, F2
9ancrod449.9F5, F2
10ximelagatran44 1110.9F5, F2
11heparinoids449.9F5, F2
12fondaparinux449.9F2, F5
13Drotrecogin alfa119.9F5, F2
14acenocoumarol44 49 1111.9F5, F2
15bivalirudin44 1110.9F5, F2
16argatroban44 1110.9F5, F2
17desogestrel44 1110.9F5, F2
18protamine sulfate449.9F2, F5
19gestodene44 1110.9F5, F2
20ofloxacin44 2 1111.8F2, F5
21penicillin449.8F5, F2
22antipyrine44 1110.8F2, F5
23ristocetin449.8F2, F5
24gamma-carboxyglutamic acid449.8F5, F2
25cyproteroneacetate449.8F5, F2
26levonorgestrel44 59 28 1112.8F2, F5
27coumarin44 2 49 2412.8F5, F2
28desmopressin44 59 28 1112.7F5, F2
29cardiolipin44 1110.7F2, F5
30hirudin449.7F5, F2
31phosphatidylethanolamine44 1110.7F2, F5
32aprotinin44 1110.7F5
33clopidogrel49 44 11 2412.7F2, NOS3
34protamine449.6F2, F5
35dermatan sulfate449.6F5, F2
36kininogen449.5F2, F5
37polyethylene glycol449.5F2, F5
38pge1449.4F2, F5
39raloxifene44 28 49 1112.4F5, NOS3
40homocysteine44 2410.3NOS3, F2, F5
41citrate449.3NOS3, F2, F5
42simvastatin44 49 59 28 11 2414.3F5, F2, NOS3
43aspirin44 49 28 2412.2NOS3, F2, F5
44tamoxifen44 49 28 1112.2NOS3, F2, F5

GO Terms for genes affiliated with Stroke, Ischemic

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16Gene Ontology
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Biological processes related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.1NOS3, F2
2platelet activationGO:0301688.7F2, PRKCH, F5
3blood coagulationGO:0075968.0NOS3, F2, PRKCH, F5

Products for genes affiliated with Stroke, Ischemic

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Sources for Stroke, Ischemic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet