MCID: STR067
MIFTS: 69

Stroke, Ischemic malady

Genetic diseases (common), Cardiovascular diseases categories

Summaries for Stroke, Ischemic

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MedlinePlus:34 A stroke is a medical emergency. strokes happen when blood flow to your brain stops. within minutes, brain cells begin to die. there are two kinds of stroke. the more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. the other kind, called hemorrhagic stroke, is caused by a blood vessel that breaks and bleeds into the brain. "mini-strokes" or transient ischemic attacks (tias), occur when the blood supply to the brain is briefly interrupted. symptoms of stroke are sudden numbness or weakness of the face, arm or leg (especially on one side of the body) sudden confusion, trouble speaking or understanding speech sudden trouble seeing in one or both eyes sudden trouble walking, dizziness, loss of balance or coordination sudden severe headache with no known cause if you have any of these symptoms, you must get to a hospital quickly to begin treatment. acute stroke therapies try to stop a stroke while it is happening by quickly dissolving the blood clot or by stopping the bleeding. post-stroke rehabilitation helps individuals overcome disabilities that result from stroke damage. drug therapy with blood thinners is the most common treatment for stroke. nih: national institute of neurological disorders and stroke

MalaCards based summary: Stroke, Ischemic, also known as cerebral infarction, is related to myocardial infarction and thrombophilia, and has symptoms including stroke An important gene associated with Stroke, Ischemic is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Sorafenib Pharmacodynamics and VEGF Signaling Pathway. The drugs dantrolene and dantrolene sodium and the compounds raloxifene and inogatran have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

OMIM:47 A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor,... (601367) more...

CDC:4 A stroke occurs when the blood supply to the brain is blocked or when a blood vessel in the brain ruptures, causing brain tissue to die.

NINDS:44 A stroke occurs when the blood supply to part of the brain is suddenly interrupted or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells. Brain cells die when they no longer receive oxygen and nutrients from the blood or there is sudden bleeding into or around the brain. The symptoms of a stroke include sudden numbness or weakness, especially on one side of the body; sudden confusion or trouble speaking or understanding speech; sudden trouble seeing in one or both eyes; sudden trouble with walking, dizziness, or loss of balance or coordination; or sudden severe headache with no known cause. There are two forms of stroke: - blockage of a blood vessel supplying the brain, and - bleeding into or around the brain.

Aliases & Classifications for Stroke, Ischemic

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Sources:
47OMIM, 33MalaCards, 32LifeMap Discovery®, 24GTR, 62UMLS, 44NINDS, 45Novoseek, 34MedlinePlus, 4CDC, 10Disease Ontology, 12DISEASES, 11diseasecard, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD10
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Related Diseases for Stroke, Ischemic

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Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 865)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.2ALOX5AP, F5, NOS3
2thrombophilia30.9F2, F5
3antiphospholipid syndrome30.8F2, F5
4hyperhomocysteinemia30.7F5, NOS3, F2
5pulmonary embolism30.7F2, F5
6protein s deficiency30.5F2, F5
7protein c deficiency30.4F2, F5
8thrombocytopenia30.4F5, F2
9proteinuria30.3ALOX5AP, NOS3
10factor vii deficiency30.1F2, F5
11hemophilia a30.1F5, F2
12disseminated intravascular coagulation30.1F2, F5
13lupus erythematosus30.1F5, F2
14liver disease30.0F5, F2
15homocysteinemia29.9F5
16hypertension, essential29.8F5, NOS3, F2
17factor v deficiency29.6F2, F5
18portal vein thrombosis29.6F2, F5
19von willebrand's disease29.6F5, F2
20liver cirrhosis29.6NOS3, F2
21cerebritis11.0
22atrial fibrillation10.8
23atherosclerosis10.8
24endotheliitis10.7
25artery disease10.7
26patent foramen ovale10.7
27central post-stroke pain10.6
28neuronitis10.6
29carotid artery occlusion10.6
30cerebral artery occlusion10.6
31encephalomyopathy10.6
32mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.6
33mitochondrial encephalomyopathy10.6
34acute myocardial infarction10.5
35aneurysm10.5
36autonomic dysfunction10.5
37atrial fibrillation and stroke10.5
38migraine10.5
39coronary artery disease10.5
40ischemic heart disease10.5
41carotid stenosis10.5
42angioedema10.5
43carotid artery disease10.5
44dementia10.5
45fibromuscular dysplasia10.5
46sickle cell anemia10.4
47carotid artery dissection10.4
48cerebrovascular disease10.4
49endocarditis10.4
50vascular disease10.4

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Symptoms for Stroke, Ischemic

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Symptoms by clinical synopsis from OMIM:

601367

Clinical features from OMIM:

601367

HPO human phenotypes related to Stroke, Ischemic:

id Description Frequency HPO Source Accession
1 stroke HP:0001297

Drugs & Therapeutics for Stroke, Ischemic

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Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Inferred drug relations via UMLS62/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

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Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke24

Anatomical Context for Stroke, Ischemic

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MalaCards organs/tissues related to Stroke, Ischemic:

33
Brain, Bone, Eye, Bone marrow, Spinal cord, Lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

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MGI Mouse Phenotypes related to Stroke, Ischemic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.1NOS3, ALOX5AP, PRKCH, F2
2MP:00053767.5NOS3, F5, ALOX5AP, PRKCH, F2
3MP:00107687.3F2, HBA1, PRKCH, F5, NOS3

Publications for Stroke, Ischemic

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Articles related to Stroke, Ischemic:

idTitleAuthorsYear
1
Glycated hemoglobin and risk of stroke, ischemic and hemorrhagic, in Japanese men and women. (18667812)
2008

Variations for Stroke, Ischemic

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Expression for genes affiliated with Stroke, Ischemic

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LifeMap Discovery
Genes differentially expressed in tissues of Stroke, Ischemic patients vs. healthy controls: 32 (show all 8)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CASP8caspase 8, apoptosis-related cysteine peptidaseBlood+1.750.000
2NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zetaBlood+1.740.000
3LINC00668long intergenic non-protein coding RNA 668Blood+1.720.000
4HERC6HECT and RLD domain containing E3 ubiquitin protein ligase family member 6Blood+1.720.000
5FAM225Afamily with sequence similarity 225, member A (non-protein coding)Blood+1.710.000
6FOXO3forkhead box O3Blood+1.710.000
7PLSCR1phospholipid scramblase 1Blood+1.710.000
8CD274CD274 moleculeBlood+1.700.000


Search GEO for disease gene expression data for Stroke, Ischemic.

Pathways for genes affiliated with Stroke, Ischemic

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Pathways related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4NOS3, PRKCH
2
Show member pathways
9.4NOS3, PRKCH
3
Show member pathways
9.4NOS3, PRKCH
4
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.4NOS3, PRKCH
59.4PRKCH, NOS3
6
Show member pathways
9.4PRKCH, NOS3
7
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.2NOS3, F2
8
Show member pathways
9.2F5, F2
9
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.2F2, F5
10
Show member pathways
9.2F5, F2
11
Show member pathways
8.6NOS3, PRKCH, F2
12
Show member pathways
thioredoxin pathway38
8.6ALOX5AP, HBA1, F2
13
Show member pathways
8.2NOS3, F5, PRKCH, F2

Compounds for genes affiliated with Stroke, Ischemic

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Compounds related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1raloxifene45 51 30 1312.9F5, NOS3
2inogatran459.6F5, F2
3ecarin459.6F2, F5
4hirugen459.6F2, F5
5spectrozyme459.6F5, F2
6danaparoid459.6F2, F5
7monoethylglycinexylidide459.6F2, F5
8batroxobin459.6F2, F5
9kaolin459.6F2, F5
10ximelagatran45 1310.6F2, F5
11ancrod459.6F2, F5
12heparinoids459.6F2, F5
13fondaparinux459.6F5, F2
14atorvastatin45 51 30 26 1313.6NOS3, F5
15bivalirudin45 1310.6F5, F2
16acenocoumarol45 51 1311.6F5, F2
17coumarins459.6F2, F5
18desogestrel45 1310.6F2, F5
19argatroban45 1310.6F2, F5
20protamine sulfate459.6F5, F2
21gestodene45 1310.6F2, F5
22ofloxacin45 3 1311.6F5, F2
23penicillin459.6F5, F2
24antipyrine45 1310.6F2, F5
25ristocetin459.6F5, F2
26gamma-carboxyglutamic acid459.5F5, F2
27clopidogrel45 51 26 1312.5NOS3, F2
28cyproteroneacetate459.5F5, F2
29levonorgestrel45 61 30 1312.5F5, F2
30desmopressin45 61 30 1312.5F2, F5
31sodium dodecylsulfate459.5NOS3, F5
32coumarin45 3 51 2612.5F2, F5
33cardiolipin45 1310.5F5, F2
34hirudin459.5F2, F5
35phosphatidylethanolamine45 1310.5F5, F2
36protamine459.5F5, F2
37dermatan sulfate459.4F2, F5
38warfarin45 51 26 1312.4F5, F2
39kininogen459.4F5, F2
40acetaminophen45 3 51 26 1313.3F2, F5
41pge1459.3F5, F2
42aprotinin45 1310.3F5, F2
43homocysteine45 2610.2F2, F5, NOS3
44citrate459.2NOS3, F5, F2
45polyethylene glycol459.2F2, F5
46simvastatin45 51 61 30 26 1314.2F2, F5, NOS3
47gf 109203x45 6110.1NOS3, PRKCH
48tamoxifen45 51 30 1312.1F2, F5, NOS3
49nitric oxide45 26 1310.9PRKCH, ALOX5AP, F5, NOS3
50aspirin45 51 30 2611.7NOS3, F5, ALOX5AP, F2

GO Terms for genes affiliated with Stroke, Ischemic

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Biological processes related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:00105448.9NOS3, F2
2platelet activationGO:00301688.6F5, PRKCH, F2
3blood coagulationGO:00075968.1NOS3, F5, PRKCH, F2

Molecular functions related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.2F5, F2

Products for genes affiliated with Stroke, Ischemic

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Sources for Stroke, Ischemic

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet