MCID: STR067
MIFTS: 74

Stroke, Ischemic malady

Cardiovascular diseases category

Summaries for Stroke, Ischemic

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46OMIM, 32MalaCards
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MalaCards: Stroke, Ischemic, also known as cerebral infarction, is related to hypertension and atherosclerosis. An important gene associated with Stroke, Ischemic is F2 (coagulation factor II (thrombin)), and among its related pathways are PEDF Induced Signaling and Thromboxane A2 receptor signaling. The drugs dantrolene and dantrolene sodium and the compounds monoethylglycinexylidide and inogatran have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and heart, and related mouse phenotype mortality/aging.

Description from OMIM:46 601367

Aliases & Classifications for Stroke, Ischemic

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Sources:
32MalaCards, 8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Stroke, Ischemic

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17GeneCards, 18GeneDecks
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Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 384)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.7NOS3, F2, F5
2atherosclerosis30.6NOS3
3protein c deficiency30.5F5, F2
4diabetes mellitus30.5NOS3, HBA1
5sickle cell anemia30.4HBA1
6hemorrhagic disease30.4F2, F5
7vasculitis30.3F2
8essential hypertension30.3NOS3
9rheumatoid arthritis30.3PRKCH
10antiphospholipid syndrome30.3F2, F5
11sickle cell disease30.2NOS3
12intracranial aneurysm30.2NOS3
13patent foramen ovale30.1F5
14vascular disease30.1HBA1
15ovarian hyperstimulation syndrome30.1F5
16retinal vein occlusion30.1F5
17thrombocytosis30.1F2
18antithrombin iii deficiency30.1F5, F2
19hepatitis a30.1F2
20pulmonary embolism30.1F2, F5
21disseminated intravascular coagulation30.1F5, F2
22deficiency anemia30.1HBA1, F2
23hyperhomocysteinemia30.1NOS3, F2, F5
24prothrombin deficiency29.9F2, F5
25factor xi deficiency29.9F5, F2
26factor vii deficiency29.9F5, F2
27factor viii deficiency29.9F5, F2
28diabetic retinopathy29.9NOS3, HBA1
29hepatocellular carcinoma29.9F2
30obesity29.8NOS3
31thrombophilia29.8F5, F2
32factor v deficiency29.8F2, F5
33portal vein thrombosis29.8F5, F2
34cadasil29.8NOS3, F2, F5
35cerebritis11.4
36cerebrovascular disease10.7
37cerebral artery occlusion10.5
38meningitis10.5
39neuronitis10.5
40ischemia10.4
41moyamoya disease10.4
42middle cerebral artery infarction10.4
43cerebral atherosclerosis10.4
44angioedema10.4
45carotid artery dissection10.4
46carotid artery occlusion10.4
47myocardial infarction10.4
48cerebral lymphoma10.3
49migraine10.3
50peripheral vascular disease10.3

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Clinical Features for Stroke, Ischemic

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46OMIM
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Clinical features from OMIM:

601367

Clinical synopsis from OMIM:

601367

Drugs & Therapeutics for Stroke, Ischemic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stroke, Ischemic

Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Search CenterWatch for Stroke, Ischemic

Inferred drug relations via UMLS60/NDF-RT40:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

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Sources:
22GTR
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Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke22

Anatomical Context for Stroke, Ischemic

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Stroke, Ischemic:

32
Brain, Bone, Heart, Endothelial, Spinal cord, Bone marrow, Lung, Testes, T cells, Monocytes, Cortex, Thyroid, B cells, Temporal lobe, Prefrontal cortex, Myeloid, Prostate, Placenta, Liver, Adipocyte, Whole blood, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Stroke, Ischemic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5NOS3, F2, HBA1, PRKCH, F5

Publications for Stroke, Ischemic

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Sources:
50PubMed
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Articles related to Stroke, Ischemic:

(show top 50)    (show all 1876)
idTitleAuthorsYear
1
Delayed ischemic stroke associated with bromocriptine-induced reversible cerebral vasoconstriction syndrome. (22419017)
2013
2
Topical distribution of initial paresis of the limbs to predict clinically relevant spasticity after ischemic stroke: a retrospective cohort study. (24346154)
2013
3
Association between TNF-I' 238G/A polymorphisms and the risk of ischemic stroke. (22937788)
2013
4
Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke. (24114454)
2013
5
Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients. (24101821)
2013
6
Association of nNOS gene polymorphism with ischemic stroke in Han Chinese of North China. (24082858)
2013
7
Long-term outcome of vertebral artery origin stenosis in patients with acute ischemic stroke. (24215371)
2013
8
Extracellular signal-regulated kinase1/2-dependent changes in tight junctions after ischemic preconditioning contributes to tolerance induction after ischemic stroke. (24005261)
2013
9
Cerebrospinal fluid biomarkers in Alzheimer's disease, vascular dementia and ischemic stroke patients: a critical analysis. (23877436)
2013
10
Ischemic stroke and patent foramen ovale: risk factors and genetic profile. (22784820)
2013
11
Time to hospital admission and start of treatment in patients with ischemic stroke in northern Italy and predictors of delay. (24296825)
2013
12
Influence of acute complications on outcome 3 months after ischemic stroke. (24086621)
2013
13
Acute-phase reactants and cytokines in ischemic stroke: do they have any relationship with short-term mortality? (24174359)
2013
14
Worldwide reported use of IV tissue plasminogen activator for acute ischemic stroke. (24207029)
2013
15
Periodontal disease and recurrent vascular events in stroke/transient ischemic attack patients. (23910516)
2013
16
Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in african americans: the jackson heart study. (24350185)
2013
17
An unusual cause of ischemic stroke with successful thrombolysis. (24008132)
2013
18
Prior Cancer in Patients with Ischemic Stroke: The Bergen NORSTROKE Study. (24075585)
2013
19
Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry. (24320947)
2013
20
Posterior circulation and high prevalence of ischemic stroke among young pediatric patients with Moyamoya disease: evidence of angiography-based differences by age at diagnosis. (20801761)
2011
21
Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke. (21354862)
2011
22
The plasminogen activator inhibitor-1 gene polymorphism in determining the risk of pediatric ischemic stroke--case control and family-based study. (21647848)
2011
23
Primary and secondary prevention of ischemic stroke. (20357456)
2010
24
Demographic and cardiovascular risk factors modify association of fasting insulin with incident coronary heart disease and ischemic stroke (from the Atherosclerosis Risk In Communities Study). (20451688)
2010
25
Matrix metalloproteinase-9 contributes to the increase of tau protein in serum during acute ischemic stroke. (20627731)
2010
26
Prothrombin G20210A mutation, hypogonadotropic hypogonadism, and generalized vitiligo-related ischemic stroke in a young adult. (20504218)
2010
27
Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and atherosclerosis, ischemic stroke and hyperhomocysteinemia. (19669932)
2010
28
Interleukin-18 promoter polymorphisms and risk of ischemic stroke. (20097272)
2010
29
Dyslipidemia as a risk factor for ischemic stroke. (19849661)
2009
30
Relationship between estradiol and antioxidant enzymes activity of ischemic stroke. (19746169)
2009
31
Complex analysis of genetic predisposition to ischemic stroke in Russians]. (19899640)
2009
32
Elevated visfatin/pre-B-cell colony-enhancing factor plasma concentration in ischemic stroke. (19717018)
2009
33
Gene and stem cell therapy in ischemic stroke. (19523331)
2009
34
Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study. (20031580)
2009
35
High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA. (18436890)
2008
36
Serial measurements of plasma homocysteine levels in early and late phases of ischemic stroke. (17222107)
2007
37
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. (17371805)
2007
38
Statin therapy after stroke or transient ischemic attack. (17139774)
2006
39
Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population. (15968394)
2005
40
Link between platelet activity and outcomes after an ischemic stroke. (16006760)
2005
41
C-reactive protein in the acute phase of ischemic stroke]. (16373025)
2005
42
Neuroprotection for ischemic stroke: two decades of success and failure. (15717006)
2004
43
The role of lipid profile in determining the risk of ischemic stroke in the elderly: a case-control study. (12849073)
2003
44
C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. (14500938)
2003
45
Ischemic injury in experimental stroke depends on angiotensin II. (11818364)
2002
46
Early carotid endarterectomy for critical carotid artery stenosis after thrombolysis therapy in acute ischemic stroke in the middle cerebral artery. (11546899)
2001
47
C-reactive protein and outcome after ischemic stroke. (10229731)
1999
48
Antiphosphatidyl serine antibodies are independently associated with ischemic stroke. (10534262)
1999
49
tPA in acute ischemic stroke: United States experience and issues for the future. (9744836)
1998
50
Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients? (8418541)
1993

Genetic Variations for Stroke, Ischemic

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Expression for genes affiliated with Stroke, Ischemic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stroke, Ischemic

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Pathways for genes affiliated with Stroke, Ischemic

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Stroke, Ischemic

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44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide4410.4F5
2inogatran449.9F2, F5
3ecarin449.9F5, F2
4hirugen449.9F5, F2
5spectrozyme449.9F2, F5
6batroxobin449.9F5, F2
7danaparoid449.9F5, F2
8kaolin449.9F5, F2
9ancrod449.9F5, F2
10ximelagatran44 1110.9F5, F2
11heparinoids449.9F5, F2
12fondaparinux449.9F2, F5
13Drotrecogin alfa119.9F5, F2
14acenocoumarol44 49 1111.9F5, F2
15bivalirudin44 1110.9F5, F2
16argatroban44 1110.9F5, F2
17desogestrel44 1110.9F5, F2
18protamine sulfate449.9F2, F5
19gestodene44 1110.9F5, F2
20ofloxacin44 2 1111.8F2, F5
21penicillin449.8F5, F2
22antipyrine44 1110.8F2, F5
23ristocetin449.8F2, F5
24gamma-carboxyglutamic acid449.8F5, F2
25cyproteroneacetate449.8F5, F2
26levonorgestrel44 59 28 1112.8F2, F5
27coumarin44 2 49 2412.8F5, F2
28desmopressin44 59 28 1112.7F5, F2
29cardiolipin44 1110.7F2, F5
30hirudin449.7F5, F2
31phosphatidylethanolamine44 1110.7F2, F5
32aprotinin44 1110.7F5
33clopidogrel49 44 11 2412.7F2, NOS3
34protamine449.6F2, F5
35dermatan sulfate449.6F5, F2
36kininogen449.5F2, F5
37polyethylene glycol449.5F2, F5
38pge1449.4F2, F5
39raloxifene44 28 49 1112.4F5, NOS3
40homocysteine44 2410.3NOS3, F2, F5
41citrate449.3NOS3, F2, F5
42simvastatin44 49 59 28 11 2414.3F5, F2, NOS3
43aspirin44 49 28 2412.2NOS3, F2, F5
44tamoxifen44 49 28 1112.2NOS3, F2, F5

GO Terms for genes affiliated with Stroke, Ischemic

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16Gene Ontology
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Biological processes related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.1NOS3, F2
2platelet activationGO:0301688.7F2, PRKCH, F5
3blood coagulationGO:0075968.0NOS3, F2, PRKCH, F5

Products for genes affiliated with Stroke, Ischemic

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  • Antibodies
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  • Antibodies

Sources for Stroke, Ischemic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet