MCID: STR067
MIFTS: 65

Stroke, Ischemic malady

Genetic diseases (common), Cardiovascular diseases categories

Aliases & Classifications for Stroke, Ischemic

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Sources:
45OMIM, 31MalaCards, 30LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 42NINDS, 11DISEASES, 43Novoseek, 22GTR, 32MedlinePlus, 3CDC, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 25ICD10
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Summaries for Stroke, Ischemic

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MedlinePlus:32 A stroke is a medical emergency. strokes happen when blood flow to your brain stops. within minutes, brain cells begin to die. there are two kinds of stroke. the more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. the other kind, called hemorrhagic stroke, is caused by a blood vessel that breaks and bleeds into the brain. "mini-strokes" or transient ischemic attacks (tias), occur when the blood supply to the brain is briefly interrupted. symptoms of stroke are sudden numbness or weakness of the face, arm or leg (especially on one side of the body) sudden confusion, trouble speaking or understanding speech sudden trouble seeing in one or both eyes sudden trouble walking, dizziness, loss of balance or coordination sudden severe headache with no known cause if you have any of these symptoms, you must get to a hospital quickly to begin treatment. acute stroke therapies try to stop a stroke while it is happening by quickly dissolving the blood clot or by stopping the bleeding. post-stroke rehabilitation helps individuals overcome disabilities that result from stroke damage. drug therapy with blood thinners is the most common treatment for stroke. nih: national institute of neurological disorders and stroke

MalaCards based summary: Stroke, Ischemic, also known as cerebral infarction, is related to myocardial infarction and thrombophilia, and has symptoms including stroke An important gene associated with Stroke, Ischemic is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are Sorafenib Pharmacodynamics and VEGF Signaling Pathway. The drugs pentoxifylline and warfarin and the compounds raloxifene and inogatran have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

OMIM:45 A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor,... (601367) more...

CDC:3 A stroke occurs when the blood supply to the brain is blocked or when a blood vessel in the brain ruptures, causing brain tissue to die.

NINDS:42 A stroke occurs when the blood supply to part of the brain is suddenly interrupted or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells. Brain cells die when they no longer receive oxygen and nutrients from the blood or there is sudden bleeding into or around the brain. The symptoms of a stroke include sudden numbness or weakness, especially on one side of the body; sudden confusion or trouble speaking or understanding speech; sudden trouble seeing in one or both eyes; sudden trouble with walking, dizziness, or loss of balance or coordination; or sudden severe headache with no known cause. There are two forms of stroke: - blockage of a blood vessel supplying the brain, and - bleeding into or around the brain.

Related Diseases for Stroke, Ischemic

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Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 865)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.1ALOX5AP, F5, NOS3
2thrombophilia31.1F2, F5
3antiphospholipid syndrome31.0F2, F5
4pulmonary embolism30.8F2, F5
5protein s deficiency30.8F2, F5
6hyperhomocysteinemia30.7F5, NOS3, F2
7protein c deficiency30.6F2, F5
8homocysteinemia30.4F5
9thrombocytopenia30.4F5, F2
10factor vii deficiency30.3F2, F5
11hemophilia a30.3F5, F2
12proteinuria30.3ALOX5AP, NOS3
13disseminated intravascular coagulation30.2F2, F5
14lupus erythematosus30.1F5, F2
15liver disease30.1F5, F2
16factor v deficiency29.9F2, F5
17portal vein thrombosis29.9F2, F5
18von willebrand's disease29.8F5, F2
19factor v leiden thrombophilia29.8F2, F5
20hypertension, essential29.8F5, NOS3, F2
21liver cirrhosis29.4NOS3, F2
22cerebritis11.0
23atrial fibrillation10.8
24atherosclerosis10.8
25endotheliitis10.7
26artery disease10.7
27patent foramen ovale10.7
28central post-stroke pain10.6
29neuronitis10.6
30carotid artery occlusion10.6
31cerebral artery occlusion10.6
32mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.6
33encephalomyopathy10.6
34mitochondrial encephalomyopathy10.6
35atrial fibrillation and stroke10.5
36acute myocardial infarction10.5
37aneurysm10.5
38autonomic dysfunction10.5
39migraine10.5
40coronary artery disease10.5
41ischemic heart disease10.5
42carotid stenosis10.5
43angioedema10.5
44carotid artery disease10.5
45dementia10.5
46fibromuscular dysplasia10.5
47sickle cell anemia10.4
48carotid artery dissection10.4
49cerebrovascular disease10.4
50endocarditis10.4

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Symptoms for Stroke, Ischemic

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Symptoms by clinical synopsis from OMIM:

601367

Clinical features from OMIM:

601367

HPO human phenotypes related to Stroke, Ischemic:

id Description Frequency HPO Source Accession
1 stroke HP:0001297

Drugs & Therapeutics for Stroke, Ischemic

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Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Inferred drug relations via UMLS60/NDF-RT39:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

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Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke22

Anatomical Context for Stroke, Ischemic

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MalaCards organs/tissues related to Stroke, Ischemic:

31
Brain, Bone, Eye, Bone marrow, Spinal cord, Lung, B cells

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

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MGI Mouse Phenotypes related to Stroke, Ischemic:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.1NOS3, ALOX5AP, PRKCH, F2
2MP:00053767.5NOS3, F5, ALOX5AP, PRKCH, F2
3MP:00107687.3F2, HBA1, PRKCH, F5, NOS3

Publications for Stroke, Ischemic

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Articles related to Stroke, Ischemic:

idTitleAuthorsYear
1
Glycated hemoglobin and risk of stroke, ischemic and hemorrhagic, in Japanese men and women. (18667812)
2008

Variations for Stroke, Ischemic

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Expression for genes affiliated with Stroke, Ischemic

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Search GEO for disease gene expression data for Stroke, Ischemic.

Pathways for genes affiliated with Stroke, Ischemic

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Pathways related to Stroke, Ischemic according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4NOS3, PRKCH
2
Show member pathways
9.4NOS3, PRKCH
3
Show member pathways
9.4NOS3, PRKCH
4
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.4NOS3, PRKCH
59.4PRKCH, NOS3
6
Show member pathways
9.4PRKCH, NOS3
7
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.2NOS3, F2
8
Show member pathways
9.2F5, F2
9
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.2F2, F5
10
Show member pathways
9.2F5, F2
11
Show member pathways
8.6NOS3, PRKCH, F2
12
Show member pathways
thioredoxin pathway36
8.6ALOX5AP, HBA1, F2
13
Show member pathways
8.2NOS3, F5, PRKCH, F2

Compounds for genes affiliated with Stroke, Ischemic

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Compounds related to Stroke, Ischemic according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1raloxifene43 49 28 1212.9F5, NOS3
2inogatran439.6F5, F2
3ecarin439.6F2, F5
4hirugen439.6F2, F5
5spectrozyme439.6F5, F2
6danaparoid439.6F2, F5
7monoethylglycinexylidide439.6F2, F5
8batroxobin439.6F2, F5
9kaolin439.6F2, F5
10ximelagatran43 1210.6F2, F5
11ancrod439.6F2, F5
12heparinoids439.6F2, F5
13fondaparinux439.6F5, F2
14atorvastatin43 49 28 24 1213.6NOS3, F5
15bivalirudin43 1210.6F5, F2
16acenocoumarol43 49 1211.6F5, F2
17coumarins439.6F2, F5
18desogestrel43 1210.6F2, F5
19argatroban43 1210.6F2, F5
20protamine sulfate439.6F5, F2
21gestodene43 1210.6F2, F5
22ofloxacin43 2 1211.6F5, F2
23penicillin439.6F5, F2
24antipyrine43 1210.6F2, F5
25ristocetin439.6F5, F2
26gamma-carboxyglutamic acid439.5F5, F2
27clopidogrel43 49 24 1212.5NOS3, F2
28cyproteroneacetate439.5F5, F2
29levonorgestrel43 59 28 1212.5F5, F2
30desmopressin43 59 28 1212.5F2, F5
31sodium dodecylsulfate439.5NOS3, F5
32coumarin43 2 49 2412.5F2, F5
33cardiolipin43 1210.5F5, F2
34hirudin439.5F2, F5
35phosphatidylethanolamine43 1210.5F5, F2
36protamine439.5F5, F2
37dermatan sulfate439.4F2, F5
38warfarin43 49 24 1212.4F5, F2
39kininogen439.4F5, F2
40acetaminophen43 2 49 24 1213.3F2, F5
41pge1439.3F5, F2
42aprotinin43 1210.3F5, F2
43homocysteine43 2410.2F2, F5, NOS3
44citrate439.2NOS3, F5, F2
45polyethylene glycol439.2F2, F5
46simvastatin43 49 59 28 24 1214.2F2, F5, NOS3
47gf 109203x43 5910.1NOS3, PRKCH
48tamoxifen43 49 28 1212.1F2, F5, NOS3
49nitric oxide43 24 1210.9PRKCH, ALOX5AP, F5, NOS3
50aspirin43 49 28 2411.7NOS3, F5, ALOX5AP, F2

GO Terms for genes affiliated with Stroke, Ischemic

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Biological processes related to Stroke, Ischemic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:00105448.9NOS3, F2
2platelet activationGO:00301688.6F5, PRKCH, F2
3blood coagulationGO:00075968.1NOS3, F5, PRKCH, F2

Molecular functions related to Stroke, Ischemic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.2F5, F2

Products for genes affiliated with Stroke, Ischemic

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Sources for Stroke, Ischemic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet