MCID: STR067
MIFTS: 64

Stroke, Ischemic malady

Cardiovascular diseases category
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Summaries for Stroke, Ischemic

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47OMIM, 33MalaCards
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MalaCards: Stroke, Ischemic, also known as cerebral infarction, is related to hypertension and cerebrovascular disease. An important gene associated with Stroke, Ischemic is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are VEGF Pathway and Apoptosis Pathway. The drugs dantrolene and dantrolene sodium and the compounds raloxifene and inogatran have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord, and related mouse phenotypes are growth/size/body and mortality/aging.

Description from OMIM:47 601367

Aliases & Classifications for Stroke, Ischemic

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Sources:
33MalaCards, 22GTR, 47OMIM, 31LifeMap Discovery™, 8Disease Ontology, 45Novoseek, 62UMLS, 10DISEASES, 9diseasecard, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Related Diseases for Stroke, Ischemic

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17GeneCards, 18GeneDecks
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Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 434)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.8NOS3, F5, F2
2cerebrovascular disease30.7F2, F5, NOS3
3vascular disease30.6NOS3, F5
4protein c deficiency30.5F2, F5
5antiphospholipid syndrome30.3F5, F2
6lupus erythematosus30.3F5, F2
7antithrombin iii deficiency30.2F2, F5
8protein s deficiency30.2F2, F5
9pulmonary embolism30.2F5, F2
10disseminated intravascular coagulation30.2F2, F5
11venous thrombosis30.2F5, F2
12deficiency anemia30.2HBA1, F2
13thromboembolism30.1NOS3, F5, F2
14hyperhomocysteinemia30.1F2, F5, NOS3
15hyperglycemia30.1NOS3, HBA1
16factor xi deficiency30.1F2, F5
17diabetic retinopathy30.1HBA1, NOS3
18factor vii deficiency30.1F5, F2
19homocysteinemia30.1F5
20portal vein thrombosis30.0F2, F5
21thrombophilia30.0F5, F2
22thrombocytopenia29.9F5, F2
23sepsis29.9F2, F5, NOS3
24cerebritis11.4
25aneurysm10.6
26meningitis10.5
27neuronitis10.5
28moyamoya disease10.5
29autonomic dysfunction10.4
30atherosclerosis10.4
31ischemia10.4
32endotheliitis10.4
33angioedema10.4
34spasticity10.4
35carotid artery dissection10.4
36cerebral artery occlusion10.4
37diabetes mellitus10.4
38migraine10.4
39peripheral vascular disease10.4
40dysphagia10.3
41pituitary apoplexy10.3
42tuberculous meningitis10.3
43aortic atherosclerosis10.3
44cerebral sinovenous thrombosis10.3
45sickle cell anemia10.3
46endocarditis10.3
47vascular dementia10.3
48takayasu's arteritis10.3
49alzheimer's disease10.3
50essential hypertension10.3

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Symptoms for Stroke, Ischemic

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47OMIM
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Symptoms by clinical synopsis from OMIM:

601367

Clinical features from OMIM:

601367

Drugs & Therapeutics for Stroke, Ischemic

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Inferred drug relations via UMLS62/NDF-RT41:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

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22GTR
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Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke22

Anatomical Context for Stroke, Ischemic

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Stroke, Ischemic:

33
Bone, Brain, Spinal cord, Lung, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Stroke, Ischemic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1NOS3, F5, PRKCH, F2
2MP:00107687.2NOS3, F5, PRKCH, HBA1, F2

Publications for Stroke, Ischemic

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52PubMed
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Articles related to Stroke, Ischemic:

idTitleAuthorsYear
1
Glycated hemoglobin and risk of stroke, ischemic and hemorrhagic, in Japanese men and women. (18667812)
2008

Variations for Stroke, Ischemic

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Sources:
1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Stroke, Ischemic:

1
id Gene Name Type Significance SNP ID Assembly Location
1F2NM_000506.3(F2): c.*97G> Asingle nucleotide variantPathogenic, association, risk factorrs1799963GRCh37Chr 11, 46761055: 46761055
2ACENM_000789.3: c.2306-117_2306-116insAF118569.1: g.14094_14382insertionBenign, Pathogenic, risk factorrs4340GRCh37Chr 17, 61565892: 61565893

Expression for genes affiliated with Stroke, Ischemic

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stroke, Ischemic

Search GEO for disease gene expression data for Stroke, Ischemic.

Pathways for genes affiliated with Stroke, Ischemic

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Sources:
50PathCards, 61Tocris Bioscience, 53QIAGEN, 60Thomson Reuters, 51PharmGKB, 57SinoBiological, 38NCBI BioSystems Database, 55Reactome, 54R&D Systems, 30KEGG
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Pathways related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4PRKCH, NOS3
2
Show member pathways
9.4PRKCH, NOS3
3
Show member pathways
9.4NOS3, PRKCH
4
Show member pathways
9.4NOS3, PRKCH
5
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.4PRKCH, NOS3
69.4NOS3, PRKCH
7
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.2NOS3, F2
8
Show member pathways
9.1F2, F5
9
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.1F2, F5
10
Show member pathways
9.1F5, F2
11
Show member pathways
thioredoxin pathway38
9.1HBA1, F2
12
Show member pathways
9.0F2, PRKCH
13
Show member pathways
8.6F2, PRKCH, NOS3
14
Show member pathways
8.1NOS3, F2, PRKCH, F5

Compounds for genes affiliated with Stroke, Ischemic

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 3BitterDB, 24HMDB, 61Tocris Bioscience
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Compounds related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1raloxifene45 51 29 1112.7NOS3, F5
2inogatran459.6F5, F2
3hirugen459.6F5, F2
4ecarin459.6F5, F2
5spectrozyme459.6F5, F2
6danaparoid459.6F2, F5
7monoethylglycinexylidide459.6F2, F5
8batroxobin459.6F2, F5
9kaolin459.6F2, F5
10ximelagatran45 1110.6F2, F5
11ancrod459.6F2, F5
12heparinoids459.6F5, F2
13fondaparinux459.5F5, F2
14acenocoumarol45 51 1111.5F2, F5
15bivalirudin45 1110.5F2, F5
16coumarins459.5F2, F5
17desogestrel45 1110.5F2, F5
18argatroban45 1110.5F2, F5
19protamine sulfate459.5F2, F5
20gestodene45 1110.5F5, F2
21ofloxacin45 3 1111.5F5, F2
22clopidogrel45 51 24 1112.5NOS3, F2
23penicillin459.5F2, F5
24atorvastatin45 51 29 24 1113.5NOS3, F5
25antipyrine45 1110.5F5, F2
26ristocetin459.5F2, F5
27gamma-carboxyglutamic acid459.5F5, F2
28cyproteroneacetate459.5F5, F2
29levonorgestrel45 61 29 1112.5F2, F5
30coumarin45 3 51 2412.5F5, F2
31desmopressin45 61 29 1112.5F5, F2
32cardiolipin45 1110.4F2, F5
33hirudin459.4F5, F2
34phosphatidylethanolamine45 1110.4F5, F2
35protamine459.4F2, F5
36sodium dodecylsulfate459.4F5, NOS3
37dermatan sulfate459.4F5, F2
38warfarin45 51 24 1112.4F5, F2
39kininogen459.3F2, F5
40acetaminophen45 3 51 24 1113.3F5, F2
41pge1459.3F5, F2
42aprotinin45 1110.2F2, F5
43polyethylene glycol459.2F5, F2
44homocysteine45 2410.1F2, F5, NOS3
45citrate459.1NOS3, F5, F2
46gf 109203x45 6110.1NOS3, PRKCH
47simvastatin45 51 61 29 24 1114.1F2, F5, NOS3
48aspirin45 51 29 2412.1NOS3, F5, F2
49tamoxifen45 51 29 1112.0NOS3, F5, F2
50nitric oxide45 24 1110.9NOS3, F5, PRKCH

GO Terms for genes affiliated with Stroke, Ischemic

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16Gene Ontology
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Biological processes related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105448.9NOS3, F2
2platelet activationGO:0301688.5F5, PRKCH, F2
3blood coagulationGO:0075968.0NOS3, F5, PRKCH, F2

Molecular functions related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.1F5, F2

Products for genes affiliated with Stroke, Ischemic

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Stroke, Ischemic

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet