MCID: STR067
MIFTS: 69

Stroke, Ischemic malady

Cardiovascular category

Summaries for Stroke, Ischemic

Sources:
47OMIM, 33MalaCards
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MalaCards: Stroke, Ischemic, also known as cerebral infarction, is related to atherosclerosis and protein c deficiency. An important gene associated with Stroke, Ischemic is F2 (coagulation factor II (thrombin)), and among its related pathways are PEDF Induced Signaling and Thromboxane A2 receptor signaling. The drugs dantrolene and dantrolene sodium and the compounds monoethylglycinexylidide and inogatran have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotype mortality/aging.

Description from OMIM:47 601367

Aliases & Classifications for Stroke, Ischemic

Sources:
33MalaCards, 8Disease Ontology, 9diseasecard, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Related Diseases for Stroke, Ischemic

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 370)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.6NOS3
2protein c deficiency30.6F5, F2
3sickle cell anemia30.4HBA1
4vasculitis30.3F2
5antiphospholipid syndrome30.3F2, F5
6sickle cell disease30.2NOS3
7venous thrombosis30.2F2, F5
8intracranial aneurysm30.2NOS3
9thromboembolism30.2NOS3, F2, F5
10thrombocytosis30.1F2
11hepatitis a30.1F2
12coronary heart disease30.1NOS3
13deficiency anemia30.1HBA1, F2
14patent foramen ovale30.1F5
15vascular disease30.1HBA1
16thalassemia30.1HBA1
17hyperhomocysteinemia30.1NOS3, F2, F5
18ovarian hyperstimulation syndrome30.1F5
19varicose veins30.0F2
20prothrombin deficiency30.0F2, F5
21factor v deficiency30.0F2, F5
22factor vii deficiency30.0F5, F2
23factor viii deficiency30.0F5, F2
24homocysteinemia29.9F5
25thrombophilia29.9F5, F2
26portal vein thrombosis29.9F5, F2
27sepsis29.9NOS3, F2, F5
28cadasil29.9NOS3, F2, F5
29cerebral artery occlusion10.5
30moyamoya disease10.4
31cerebral atherosclerosis10.4
32middle cerebral artery infarction10.4
33angioedema10.4
34carotid artery dissection10.4
35cerebral lymphoma10.4
36n syndrome10.4
37peripheral vascular disease10.4
38dysphagia10.3
39pituitary apoplexy10.3
40carotid artery occlusion10.3
41tuberculous meningitis10.3
42takayasu's arteritis10.3
43aortic atherosclerosis10.3
44cerebral sinovenous thrombosis10.3
45arthritis10.3
46testicular cancer10.3
47spasticity10.3
48vascular dementia10.2
49alzheimer's disease10.2
50aortic disease10.2

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Clinical Features for Stroke, Ischemic

Sources:
47OMIM
See all sources

Clinical features from OMIM:

601367

Clinical synopsis from OMIM:

601367

Drugs & Therapeutics for Stroke, Ischemic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Stroke, Ischemic

Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Search CenterWatch for Stroke, Ischemic

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

Sources:
22GTR
See all sources

Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke22

Anatomical Context for Stroke, Ischemic

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Stroke, Ischemic:

33
Bone marrow, Whole blood, Brain, Cortex, Spinal cord, Heart, Small intestine, Adipocyte, Liver, Lung, Thyroid, Placenta, Prostate, Myeloid, Monocytes, T cells, B cells, Endothelial, Prefrontal cortex, Temporal lobe, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Stroke, Ischemic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5NOS3, F2, HBA1, PRKCH, F5

Publications for Stroke, Ischemic

Sources:
51PubMed
See all sources

Articles related to Stroke, Ischemic:

(show top 50)    (show all 1880)
idTitleAuthorsYear
1
Gait analysis in a pre- and post-ischemic stroke biomedical pig model. (24286894)
2014
2
Intra-arterial treatment of acute ischemic stroke: the continued evolution. (24398801)
2014
3
Repeated Episodes of Ischemic Stroke over a Short Period in a Patient with Essential Thrombocythemia on Anticoagulant Therapy. (22898586)
2014
4
Rupture of nonstenotic carotid plaque as a cause of ischemic stroke evidenced by multimodality imaging. (24396017)
2014
5
Somatic awareness and symptom attribution in ischemic stroke patients. (24399167)
2014
6
Translational perspectives on perfusion-diffusion mismatch in ischemic stroke. (24215361)
2013
7
Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke. (23356535)
2013
8
Paradoxical effect of obesity on hemorrhagic transformation after acute ischemic stroke. (24053109)
2013
9
Cerebroprotective Effect of Moringa oleifera against Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion. (24367723)
2013
10
Gene Variations of ROCKs and Risk of Ischemic Stroke: The Women's Genome Health Study. (24351102)
2013
11
Reduction in early stroke risk in carotid stenosis with transient ischemic attack associated with statin treatment. (23908061)
2013
12
Is there a correlation between hs-CRP levels and functional outcome of Ischemic Stroke? (24353532)
2013
13
Arterial Ischemic Stroke As a Complication to Disseminated Infection with Fusobacterium necrophorum. (24227208)
2013
14
Convalescent plasma levels of TAFI activation peptide predict death and recurrent vascular events in ischemic stroke survivors. (22260642)
2012
15
Coronary artery disease, cerebral non-fatal ischemic stroke in retinal vein occlusion: an 8-yr follow-up. (20674314)
2012
16
Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case-control study in a Northern Indian population. (21406306)
2011
17
A case of ischemic stroke in acute promyelocytic leukemia at initial presentation. Relevance of all-trans retinoic acid treatment. (20041837)
2010
18
Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study. (20622166)
2010
19
Acute myocardial infarction following intravenous tissue plasminogen activator for acute ischemic stroke: An unknown danger. (20436751)
2010
20
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. (20385928)
2010
21
Hyperthyroidism and risk of ischemic stroke in young adults: a 5-year follow-up study. (20360542)
2010
22
Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis. (18715563)
2009
23
An acute ischemic stroke secondary to sphenoid sinusitis. (19924653)
2009
24
Low protein Z levels but not the protein Z gene G79A polymorphism are a risk factor for ischemic stroke. (18378283)
2008
25
Cilostazol reduces PAC-1 expression on platelets in ischemic stroke. (19513289)
2008
26
Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial. (18070096)
2008
27
Angiotensin-converting enzyme insertion/deletion polymorphism and the risk of ischemic stroke in a South Indian population. (18586276)
2008
28
Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke. (18793781)
2008
29
Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21. (18340101)
2008
30
Effect of aspirin on lipoprotein(a) in patients with ischemic stroke. (17845920)
2007
31
Hypercoagulation testing in ischemic stroke. (17550316)
2007
32
Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study. (16990411)
2006
33
Transient prosopagnosia after ischemic stroke. (16567712)
2006
34
Role of endoglin and transforming growth factor-beta in progressive white matter damage after an ischemic stroke. (16961065)
2006
35
Assessment of relations between clinical outcome of ischemic stroke and activity of inflammatory processes in the acute phase based on examination of selected parameters. (15956787)
2005
36
Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study. (16314544)
2005
37
Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population. (16162858)
2005
38
Statins after ischemic stroke and transient ischemic attack: an advisory statement from the Stroke Council, American Heart Association and American Stroke Association. (15044812)
2004
39
Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. (12511748)
2003
40
Factor V Leiden mutation and patent foramen ovale in ischemic stroke. (12522679)
2002
41
Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. (11692019)
2001
42
Presumed pre- or perinatal arterial ischemic stroke: risk factors and outcomes. (11506398)
2001
43
Lipoprotein (a) and apolipoprotein E epsilon 4 as independent risk factors for ischemic stroke. (10197285)
1999
44
A hypercoagulable state in activated protein C resistant patients with ischemic stroke. (9594367)
1998
45
Acute phase proteins: alpha-1-acid glycoprotein (AGP) and alpha-1 antichymotrypsin (ACT) in serum of patients with cerebral ischemic stroke]. (9770687)
1998
46
Intravenous t-PA for acute ischemic stroke: therapeutic yield of a stroke code system. (9484380)
1998
47
Hemostatic markers in acute ischemic stroke. Association with stroke type, severity, and outcome. (8711789)
1996
48
Ischemic stroke and activated protein C resistance. (7563524)
1995
49
Ischemic stroke in young patients with activated protein C resistance. A report of three cases belonging to three different kindreds. (7740584)
1995
50
Ischemic stroke due to protein C deficiency. (2195715)
1990

Genetic Variations for Stroke, Ischemic

Expression for genes affiliated with Stroke, Ischemic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stroke, Ischemic

Search GEO for disease gene expression data for Stroke, Ischemic.

Pathways for genes affiliated with Stroke, Ischemic

Sources:
52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 30KEGG, 53R&D Systems
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Compounds for genes affiliated with Stroke, Ischemic

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 2BitterDB, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide4510.4F5
2inogatran459.9F2, F5
3ecarin459.9F5, F2
4hirugen459.9F5, F2
5spectrozyme459.9F2, F5
6batroxobin459.9F5, F2
7danaparoid459.9F5, F2
8kaolin459.9F5, F2
9ancrod459.9F5, F2
10ximelagatran45 1110.9F5, F2
11heparinoids459.9F5, F2
12fondaparinux459.9F2, F5
13Drotrecogin alfa119.9F5, F2
14acenocoumarol45 50 1111.9F5, F2
15bivalirudin45 1110.9F5, F2
16argatroban45 1110.9F5, F2
17desogestrel45 1110.9F5, F2
18protamine sulfate459.9F2, F5
19gestodene45 1110.9F5, F2
20ofloxacin45 2 1111.8F2, F5
21penicillin459.8F5, F2
22antipyrine45 1110.8F2, F5
23ristocetin459.8F2, F5
24gamma-carboxyglutamic acid459.8F5, F2
25cyproteroneacetate459.8F5, F2
26levonorgestrel45 60 29 1112.8F2, F5
27coumarin45 2 50 2412.8F5, F2
28desmopressin45 60 29 1112.7F5, F2
29cardiolipin45 1110.7F2, F5
30hirudin459.7F5, F2
31phosphatidylethanolamine45 1110.7F2, F5
32aprotinin45 1110.7F5
33clopidogrel50 45 11 2412.7F2, NOS3
34protamine459.6F2, F5
35dermatan sulfate459.6F5, F2
36kininogen459.5F2, F5
37polyethylene glycol459.5F2, F5
38pge1459.4F2, F5
39raloxifene45 29 50 1112.4F5, NOS3
40homocysteine45 2410.3NOS3, F2, F5
41citrate459.3NOS3, F2, F5
42simvastatin45 50 60 29 11 2414.3F5, F2, NOS3
43aspirin45 50 29 2412.2NOS3, F2, F5
44tamoxifen45 50 29 1112.2NOS3, F2, F5

GO Terms for genes affiliated with Stroke, Ischemic

Sources:
16Gene Ontology
See all sources

Biological processes related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.1NOS3, F2
2platelet activationGO:0301688.7F2, PRKCH, F5
3blood coagulationGO:0075968.0NOS3, F2, PRKCH, F5

Products for genes affiliated with Stroke, Ischemic

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Stroke, Ischemic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet