MCID: STR067
MIFTS: 65

Stroke, Ischemic malady

Cardiovascular diseases category
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Summaries for Stroke, Ischemic

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MalaCards based summary: Stroke, Ischemic, also known as cerebral infarction, is related to hypertension and protein c deficiency, and has symptoms including An important gene associated with Stroke, Ischemic is NOS3 (nitric oxide synthase 3 (endothelial cell)), and among its related pathways are VEGF Pathway and Apoptosis Pathway. The drugs heparin and heparin sodium and the compounds raloxifene and inogatran have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord, and related mouse phenotypes are growth/size/body and mortality/aging.

Description from OMIM:46 601367

Aliases & Classifications for Stroke, Ischemic

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Sources:
32MalaCards, 30LifeMap Discovery®, 22GTR, 46OMIM, 8Disease Ontology, 44Novoseek, 62UMLS, 10DISEASES, 9diseasecard, 57SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Stroke, Ischemic

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Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 453)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.7NOS3, F5, F2
2protein c deficiency30.7F2, F5
3cerebrovascular disease30.6F2, F5, NOS3
4vascular disease30.6NOS3, F5
5homocysteinemia30.5F5
6antiphospholipid syndrome30.5F5, F2
7antithrombin iii deficiency30.4F2, F5
8protein s deficiency30.4F2, F5
9pulmonary embolism30.3F5, F2
10disseminated intravascular coagulation30.3F2, F5
11venous thrombosis30.3F5, F2
12factor xi deficiency30.3F2, F5
13lupus erythematosus30.3F5, F2
14diabetic retinopathy30.3HBA1, NOS3
15factor vii deficiency30.2F5, F2
16deficiency anemia30.2HBA1, F2
17portal vein thrombosis30.2F2, F5
18thrombophilia30.1F5, F2
19thromboembolism30.1NOS3, F5, F2
20hyperhomocysteinemia30.1F2, F5, NOS3
21hyperglycemia30.0NOS3, HBA1
22thrombocytopenia30.0F5, F2
23sepsis29.8F2, F5, NOS3
24cerebritis11.4
25meningitis10.6
26aneurysm10.6
27neuronitis10.5
28ischemia10.5
29moyamoya disease10.5
30autonomic dysfunction10.5
31endotheliitis10.4
32spasticity10.4
33angioedema10.4
34atherosclerosis10.4
35sickle cell anemia10.4
36pituitary apoplexy10.4
37carotid artery dissection10.4
38diabetes mellitus10.4
39cerebral artery occlusion10.4
40migraine10.4
41tuberculous meningitis10.4
42hemophilia b10.4F2
43peripheral vascular disease10.4
44factor xii deficiency10.4F5
45dysphagia10.4
46central retinal vein occlusion10.4F5
47aortic atherosclerosis10.3
48cerebral sinovenous thrombosis10.3
49endocarditis10.3
50arthritis10.3

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Symptoms for Stroke, Ischemic

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Symptoms by clinical synopsis from OMIM:

601367

Clinical features from OMIM:

601367

HPO human phenotypes related to Stroke, Ischemic:

id Description Frequency HPO Source Accession
1 stroke HP:0001297

Drugs & Therapeutics for Stroke, Ischemic

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Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Inferred drug relations via UMLS62/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

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Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke22

Anatomical Context for Stroke, Ischemic

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MalaCards organs/tissues related to Stroke, Ischemic:

32
Bone, Brain, Spinal cord, Bone marrow, Lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

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MGI Mouse Phenotypes related to Stroke, Ischemic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1NOS3, F5, PRKCH, F2
2MP:00107687.2NOS3, F5, PRKCH, HBA1, F2

Publications for Stroke, Ischemic

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Articles related to Stroke, Ischemic:

idTitleAuthorsYear
1
Glycated hemoglobin and risk of stroke, ischemic and hemorrhagic, in Japanese men and women. (18667812)
2008

Variations for Stroke, Ischemic

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Expression for genes affiliated with Stroke, Ischemic

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Expression patterns in normal tissues for genes affiliated with Stroke, Ischemic

Search GEO for disease gene expression data for Stroke, Ischemic.

Pathways for genes affiliated with Stroke, Ischemic

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Pathways related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4NOS3, PRKCH
2
Show member pathways
9.4NOS3, PRKCH
3
Show member pathways
9.4NOS3, PRKCH
4
Show member pathways
9.4PRKCH, NOS3
5
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.4NOS3, PRKCH
69.4NOS3, PRKCH
7
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.2NOS3, F2
8
Show member pathways
9.1F2, F5
9
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.1F5, F2
10
Show member pathways
9.1F2, F5
11
Show member pathways
thioredoxin pathway37
9.1HBA1, F2
12
Show member pathways
9.0PRKCH, F2
13
Show member pathways
8.6NOS3, PRKCH, F2
14
Show member pathways
8.1NOS3, F5, PRKCH, F2

Compounds for genes affiliated with Stroke, Ischemic

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Compounds related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1raloxifene44 50 28 1112.7F5, NOS3
2inogatran449.6F5, F2
3hirugen449.6F5, F2
4ecarin449.6F5, F2
5spectrozyme449.6F5, F2
6batroxobin449.6F2, F5
7danaparoid449.6F5, F2
8monoethylglycinexylidide449.6F5, F2
9ancrod449.6F2, F5
10kaolin449.6F2, F5
11ximelagatran44 1110.6F5, F2
12heparinoids449.6F5, F2
13fondaparinux449.5F5, F2
14acenocoumarol44 50 1111.5F5, F2
15bivalirudin44 1110.5F2, F5
16desogestrel44 1110.5F5, F2
17coumarins449.5F2, F5
18argatroban44 1110.5F5, F2
19protamine sulfate449.5F5, F2
20gestodene44 1110.5F5, F2
21ofloxacin44 2 1111.5F5, F2
22clopidogrel44 50 24 1112.5NOS3, F2
23penicillin449.5F5, F2
24atorvastatin44 50 28 24 1113.5F5, NOS3
25antipyrine44 1110.5F2, F5
26ristocetin449.5F5, F2
27gamma-carboxyglutamic acid449.5F2, F5
28cyproteroneacetate449.5F5, F2
29levonorgestrel44 61 28 1112.5F5, F2
30desmopressin44 61 28 1112.5F5, F2
31coumarin44 2 50 2412.5F2, F5
32cardiolipin44 1110.4F2, F5
33hirudin449.4F5, F2
34phosphatidylethanolamine44 1110.4F5, F2
35protamine449.4F5, F2
36sodium dodecylsulfate449.4F5, NOS3
37dermatan sulfate449.4F2, F5
38warfarin44 50 24 1112.4F5, F2
39kininogen449.3F2, F5
40acetaminophen44 2 50 24 1113.3F5, F2
41pge1449.3F5, F2
42aprotinin44 1110.2F2, F5
43polyethylene glycol449.2F5, F2
44homocysteine44 2410.1F2, F5, NOS3
45citrate449.1NOS3, F5, F2
46gf 109203x44 6110.1NOS3, PRKCH
47simvastatin44 50 61 28 24 1114.1NOS3, F2, F5
48aspirin44 50 28 2412.1NOS3, F5, F2
49tamoxifen44 50 28 1112.0F2, F5, NOS3
50nitric oxide44 24 1110.9PRKCH, NOS3, F5

GO Terms for genes affiliated with Stroke, Ischemic

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Biological processes related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105448.9NOS3, F2
2platelet activationGO:0301688.5F5, PRKCH, F2
3blood coagulationGO:0075968.0NOS3, F5, PRKCH, F2

Molecular functions related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.1F5, F2

Products for genes affiliated with Stroke, Ischemic

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  • Proteins
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Sources for Stroke, Ischemic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet