MCID: STR067
MIFTS: 74

Stroke, Ischemic malady

Cardiovascular diseases category

Summaries for Stroke, Ischemic

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46OMIM, 32MalaCards
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MalaCards: Stroke, Ischemic, also known as cerebral infarction, is related to hypertension and atherosclerosis. An important gene associated with Stroke, Ischemic is F2 (coagulation factor II (thrombin)), and among its related pathways are PEDF Induced Signaling and Thromboxane A2 receptor signaling. The drugs dantrolene and dantrolene sodium and the compounds monoethylglycinexylidide and inogatran have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and heart, and related mouse phenotype mortality/aging.

Description from OMIM:46 601367

Aliases & Classifications for Stroke, Ischemic

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Sources:
32MalaCards, 8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Stroke, Ischemic

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17GeneCards, 18GeneDecks
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Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 384)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.7NOS3, F2, F5
2atherosclerosis30.6NOS3
3protein c deficiency30.5F5, F2
4diabetes mellitus30.5NOS3, HBA1
5sickle cell anemia30.4HBA1
6hemorrhagic disease30.4F2, F5
7vasculitis30.3F2
8essential hypertension30.3NOS3
9rheumatoid arthritis30.3PRKCH
10antiphospholipid syndrome30.3F2, F5
11sickle cell disease30.2NOS3
12intracranial aneurysm30.2NOS3
13patent foramen ovale30.1F5
14vascular disease30.1HBA1
15ovarian hyperstimulation syndrome30.1F5
16retinal vein occlusion30.1F5
17thrombocytosis30.1F2
18antithrombin iii deficiency30.1F5, F2
19hepatitis a30.1F2
20pulmonary embolism30.1F2, F5
21disseminated intravascular coagulation30.1F5, F2
22deficiency anemia30.1HBA1, F2
23hyperhomocysteinemia30.1NOS3, F2, F5
24prothrombin deficiency29.9F2, F5
25factor xi deficiency29.9F5, F2
26factor vii deficiency29.9F5, F2
27factor viii deficiency29.9F5, F2
28diabetic retinopathy29.9NOS3, HBA1
29hepatocellular carcinoma29.9F2
30obesity29.8NOS3
31thrombophilia29.8F5, F2
32factor v deficiency29.8F2, F5
33portal vein thrombosis29.8F5, F2
34cadasil29.8NOS3, F2, F5
35cerebritis11.4
36cerebrovascular disease10.7
37cerebral artery occlusion10.5
38meningitis10.5
39neuronitis10.5
40ischemia10.4
41moyamoya disease10.4
42middle cerebral artery infarction10.4
43cerebral atherosclerosis10.4
44angioedema10.4
45carotid artery dissection10.4
46carotid artery occlusion10.4
47myocardial infarction10.4
48cerebral lymphoma10.3
49migraine10.3
50peripheral vascular disease10.3

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to stroke, ischemic

Clinical Features for Stroke, Ischemic

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Sources:
46OMIM
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Clinical features from OMIM:

601367

Clinical synopsis from OMIM:

601367

Drugs & Therapeutics for Stroke, Ischemic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Stroke, Ischemic

Drug clinical trials:

Search ClinicalTrials for Stroke, Ischemic

Search NIH Clinical Center for Stroke, Ischemic

Search CenterWatch for Stroke, Ischemic

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905
Bone marrow-derived mononuclear cells (family), PMID: 22960888
Bone marrow-derived mononuclear cells, PMIDs: 20629187, 20395386
Bone marrow-derived mononuclear cells, PMID: 17635049
Neural stem cells, PMID: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736
Fetal spinal cord stem cells (NSI-566), PMIDs: 22415942, 19326469
Olfactory ensheathing cells
Placenta-derived stem cells, PMID: 22469567
Neural stem cell line (CTX0E03), PMIDs: 19633272, 23185625, 17981710
Mesenchymal stem cells-derived neuronal cells, PMIDs: 19530164, 23430693, 20350349, 21982515
Notch-transfected mesenchymal stromal cells (SB623) , PMIDs: 19530164, 23430693, 20350349, 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne, PMID: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Genetic Tests for Stroke, Ischemic

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Sources:
22GTR
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Genetic tests related to Stroke, Ischemic:

id Genetic test Affiliating Genes
1 Ischemic Stroke22

Anatomical Context for Stroke, Ischemic

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Stroke, Ischemic:

32
Brain, Bone, Heart, Endothelial, Spinal cord, Bone marrow, Lung, Testes, T cells, Monocytes, Cortex, Thyroid, B cells, Temporal lobe, Prefrontal cortex, Myeloid, Prostate, Placenta, Liver, Adipocyte, Whole blood, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells  

Animal Models for Stroke, Ischemic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Stroke, Ischemic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5NOS3, F2, HBA1, PRKCH, F5

Publications for Stroke, Ischemic

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Sources:
50PubMed
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Articles related to Stroke, Ischemic:

(show top 50)    (show all 1876)
idTitleAuthorsYear
1
Acute Ischemic Stroke: Time, Penumbra, and Reperfusion. (24399376)
2014
2
Regulation of CARD8 Expression by ANRIL and Association of CARD8 Single Nucleotide Polymorphism rs2043211 (p.C10X) With Ischemic Stroke. (24385277)
2014
3
Letter by Taguchi et al Regarding Article, "Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial". (24326449)
2014
4
Intravenous thrombolysis for acute ischemic stroke occurring during hospitalization for transient ischemic attack. (23981541)
2013
5
Peripheral vascular disease as remote ischemic preconditioning, for acute stroke. (23958050)
2013
6
Do-not-resuscitate orders, quality of care, and outcomes in veterans with acute ischemic stroke. (24000401)
2013
7
Transient ischemic attack and stroke in systemic lupus erythematosus. (24097997)
2013
8
Intraprocedural parenchymal blood volume as a marker of reperfusion status in acute ischemic stroke intervention. (23997122)
2013
9
Brain-derived neurotrophic factor G196A polymorphism predicts 90-day outcome of ischemic stroke in Chinese: a novel finding. (24035862)
2013
10
ACP Journal Club. Adding clopidogrel to aspirin after TIA or minor ischemic stroke reduced stroke without increasing bleeding. (24126666)
2013
11
Interaction Between vWF Levels and Aspirin Resistance in Ischemic Stroke Patients. (24323374)
2013
12
Chronic HCV infection is a risk factor of ischemic stroke. (24125405)
2013
13
Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke. (24386515)
2013
14
Thrombolysis for children with acute ischemic stroke: a perspective from the kids' inpatient database. (24139532)
2013
15
Hydrocephalus following decompressive craniectomy for ischemic stroke. (23564151)
2013
16
Comparison of Aspirin Response Measured by Urinary 11-Dehydrothromboxane B2 and VerifyNow Aspirin Assay in Patients with Ischemic Stroke. (24126290)
2013
17
Microglial responses after ischemic stroke and intracerebral hemorrhage. (24223607)
2013
18
Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. (23272150)
2012
19
Impact of Protocol Deviations in Acute Ischemic Stroke Treated With Intravenous rt-PA Within 4.5 Hours After Symptom Onset. (23983868)
2012
20
Multiple causes for an ischemic stroke: myxoma, papillary fibroelastomas and patent foramen ovale. (23439976)
2012
21
Angiotensin-converting enzyme insertion/deletion polymorphism contributes to ischemic stroke risk: a meta-analysis of 50 case-control studies. (23049705)
2012
22
Genetic variants of connexin37 are associated with carotid intima-medial thickness and future onset of ischemic stroke. (21044781)
2011
23
The role of ACE gene polymorphism on pathogenesis of ischemic stroke. (21979279)
2011
24
Does serum Tau protein predict the outcome of patients with ischemic stroke? (20549384)
2011
25
Hyperhomocysteinemia, folateo and B12 vitamin in Iranian patients with acute ischemic stroke. (22577454)
2011
26
Acute ischemic stroke complicating carotid sinus massage in the absence of carotid artery disease and failure of thrombolytic therapy. (20562806)
2010
27
Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke. (19863297)
2009
28
Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. (19403135)
2009
29
Prior statin use, intracranial hemorrhage, and outcome after intra-arterial thrombolysis for acute ischemic stroke. (19265056)
2009
30
Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke. (19903149)
2009
31
Antiplatelet therapy for secondary prevention of noncardioembolic ischemic stroke: a critical review. (18369175)
2008
32
Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. (19029462)
2008
33
Factors associated with incident ischemic stroke in hospitalized heart failure patients: a pilot study. (18360049)
2008
34
New era has begun since the approval of thrombolytic therapy for acute ischemic stroke in Japan]. (19198107)
2008
35
Study of genetic polymorphism of heat shock protein 70-1 associated with susceptibility to ischemic stroke]. (17555092)
2007
36
Non-selective cation channels, transient receptor potential channels and ischemic stroke. (17446049)
2007
37
Ischemic stroke in the setting of tuberculous meningitis. (17032389)
2006
38
Predicting abnormal coagulation in ischemic stroke: reducing delay in rt-PA use. (17101901)
2006
39
Anticoagulation strategies for treatment of ischemic stroke and antiphospholipid syndrome: case report and review of the literature. (16999662)
2006
40
Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study. (16286603)
2005
41
Hemostatic risk factors in ischemic stroke. (14652642)
2003
42
Combined genetic defects in a child with ischemic stroke: case report. (12269733)
2002
43
Thrombolytic therapy for acute ischemic stroke. (14728027)
2001
44
Thrombolytic therapy for ischemic stroke--a review. Part I--Intravenous thrombolysis. (11546993)
2001
45
Prospective study of apolipoprotein E genotype and functional outcome following ischemic stroke. (11030801)
2000
46
Can emergency department physicians safely and effectively initiate thrombolysis for acute ischemic stroke? (11134376)
2000
47
Plasminogen activator inhibitor-1 in patients with ischemic stroke. (11450024)
2000
48
Anticardiolipin antibodies in young Saudis with ischemic stroke. (17341924)
1998
49
Deletion polymorphism in the angiotensin-converting enzyme gene in patients with a history of ischemic stroke. (8620347)
1996
50
Serum lipoprotein pattern variations in dementia and ischemic stroke. (2330821)
1990

Genetic Variations for Stroke, Ischemic

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Expression for genes affiliated with Stroke, Ischemic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stroke, Ischemic

Search GEO for disease gene expression data for Stroke, Ischemic.

Pathways for genes affiliated with Stroke, Ischemic

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Stroke, Ischemic

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Stroke, Ischemic according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide4410.4F5
2inogatran449.9F2, F5
3ecarin449.9F5, F2
4hirugen449.9F5, F2
5spectrozyme449.9F2, F5
6batroxobin449.9F5, F2
7danaparoid449.9F5, F2
8kaolin449.9F5, F2
9ancrod449.9F5, F2
10ximelagatran44 1110.9F5, F2
11heparinoids449.9F5, F2
12fondaparinux449.9F2, F5
13Drotrecogin alfa119.9F5, F2
14acenocoumarol44 49 1111.9F5, F2
15bivalirudin44 1110.9F5, F2
16argatroban44 1110.9F5, F2
17desogestrel44 1110.9F5, F2
18protamine sulfate449.9F2, F5
19gestodene44 1110.9F5, F2
20ofloxacin44 2 1111.8F2, F5
21penicillin449.8F5, F2
22antipyrine44 1110.8F2, F5
23ristocetin449.8F2, F5
24gamma-carboxyglutamic acid449.8F5, F2
25cyproteroneacetate449.8F5, F2
26levonorgestrel44 59 28 1112.8F2, F5
27coumarin44 2 49 2412.8F5, F2
28desmopressin44 59 28 1112.7F5, F2
29cardiolipin44 1110.7F2, F5
30hirudin449.7F5, F2
31phosphatidylethanolamine44 1110.7F2, F5
32aprotinin44 1110.7F5
33clopidogrel49 44 11 2412.7F2, NOS3
34protamine449.6F2, F5
35dermatan sulfate449.6F5, F2
36kininogen449.5F2, F5
37polyethylene glycol449.5F2, F5
38pge1449.4F2, F5
39raloxifene44 28 49 1112.4F5, NOS3
40homocysteine44 2410.3NOS3, F2, F5
41citrate449.3NOS3, F2, F5
42simvastatin44 49 59 28 11 2414.3F5, F2, NOS3
43aspirin44 49 28 2412.2NOS3, F2, F5
44tamoxifen44 49 28 1112.2NOS3, F2, F5

GO Terms for genes affiliated with Stroke, Ischemic

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16Gene Ontology
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Biological processes related to Stroke, Ischemic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of platelet activationGO:0105449.1NOS3, F2
2platelet activationGO:0301688.7F2, PRKCH, F5
3blood coagulationGO:0075968.0NOS3, F2, PRKCH, F5

Products for genes affiliated with Stroke, Ischemic

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  • Antibodies
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  • Antibodies

Sources for Stroke, Ischemic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet