MCID: STR072
MIFTS: 43

Stromal Keratitis malady

Eye diseases, Rare diseases categories

Summaries for Stromal Keratitis

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34MalaCards
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MalaCards: Stromal Keratitis is related to keratitis and uveitis. An important gene associated with Stromal Keratitis is AIMP1 (aminoacyl tRNA synthetase complex-interacting multifunctional protein 1), and among its related pathways are TSLP Signaling Pathway and Cytokine production by Th17 cells in CF. The compounds mip-3alpha and larc have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Stromal Keratitis

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50Orphanet, 63UMLS, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 50 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

50
stromal keratitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

stromal keratitis 50 63


External Ids:

SNOMED-CT via Orphanet60 1763009
UMLS via Orphanet64 C1318020
ICD10 via Orphanet27 H16.3

Related Diseases for Stromal Keratitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis31.9IL17A
2uveitis30.3IL2RA, IL17A, CD69
3herpes simplex10.9
4eye disease10.4
5endotheliitis10.4
6iritis10.2
7corneal neovascularization10.2
8blindness10.2
9thyroiditis10.1CIITA
10lyme disease10.1
11herpes zoster10.1
12b cell deficiency10.1
13corneal edema10.1
14dysgammaglobulinemia10.1
15iridocyclitis10.1
16scleritis10.1
17anterior uveitis10.1
18herpes zoster ophthalmicus10.1
19adult t-cell leukemia10.1TRB, IL2RA
20relapsing-remitting multiple sclerosis10.1IL2RA, TRB
21sezary's disease10.1IL2RA, TRB
22pulmonary sarcoidosis10.1IL2RA, TRB
23peripheral t-cell lymphoma10.1IL2RA, TRB
24juvenile rheumatoid arthritis10.0TRB, IL2RA
25kawasaki disease10.0CIITA, TRB
26hypereosinophilic syndrome10.0IL2RA, CD69
27mastocytosis10.0CD69, IL2RA
28mycosis fungoides10.0TRB, IL2RA
29pleurisy10.0TRB, LCN1, IL2RA
30cutaneous t cell lymphoma10.0IL2RA, TRB
31toxic shock syndrome10.0CD69, CIITA
32graft versus host disease10.0TRB, IL2RA
33thymoma10.0CD69, TRB
34non-hodgkin lymphoma10.0CCR6, IL2RA, TRB
35celiac disease10.0TRB, CIITA
36lymphopenia10.0CIITA, IL2RA
37sarcoidosis10.0IL2RA, CD69, TRB
38lupus nephritis10.0IL2RA, CIITA
39autoimmune thyroiditis10.0CIITA, IL2RA
40connective tissue disease10.0CD69, IL2RA
41type 1 diabetes mellitus10.0CIITA, CD69, TRB
42vasculitis10.0TNFSF4, IL17A, TRB
43severe combined immunodeficiency10.0TRB, IL2RA, CIITA
44myeloma10.0TRB, CCR6, CIITA
45sjogren's syndrome10.0TRB, IL2RA, CIITA
46immunodeficiency with hyper igm type 210.0CD69, CCR6, CIITA
47tetanus10.0CD69, IL2RA, CIITA
48cystic fibrosis10.0CCL20, IL17A, TRB
49galactosemia10.0IL17A, CCR6, CCL20
50hepatitis b10.0IL2RA, IL17A, TRB

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms for Stromal Keratitis

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Drugs & Therapeutics for Stromal Keratitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Stromal Keratitis

Drug clinical trials:

Search ClinicalTrials for Stromal Keratitis

Search NIH Clinical Center for Stromal Keratitis

Search CenterWatch for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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34MalaCards
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MalaCards organs/tissues related to Stromal Keratitis:

34
Eye, T cells, Endothelial, Lymph node, Skin, B cells

Animal Models for Stromal Keratitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Stromal Keratitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.0CIITA, CCR6, IL2RA, IL17A, IL17RA, CD69
2MP:00053875.9TRB, AIMP1, TNFSF4, CIITA, CCR6, IL2RA

Publications for Stromal Keratitis

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53PubMed
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Articles related to Stromal Keratitis:

(show top 50)    (show all 182)
idTitleAuthorsYear
1
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
2
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
3
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
4
Elevated intraocular pressure-induced interlamellar stromal keratitis occurring 9 years after laser in situ keratomileusis. (21941173)
2012
5
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
6
Recurrent herpetic stromal keratitis in mice: a model for studying human HSK. (22593769)
2012
7
Intraocular invasion by microsporidial spores in a case of stromal keratitis. (21482880)
2011
8
A crucial role for B and T lymphocyte attenuator in preventing the development of CD4+ T cell-mediated herpetic stromal keratitis. (21042564)
2010
9
Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis. (19204233)
2009
10
Amniotic membrane transplantation induces apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis. (19255156)
2009
11
Management of herpes simplex virus stromal keratitis: an evidence-based review. (19298901)
2009
12
Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis. (18689698)
2008
13
Interferon gamma is not required for recurrent herpetic stromal keratitis. (18755490)
2008
14
Granulocyte macrophage colony-stimulating factor expression in human herpetic stromal keratitis: implications for the role of neutrophils in HSK. (17197544)
2007
15
Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. (16997857)
2006
16
Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects. (16951377)
2006
17
Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines. (16178874)
2005
18
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. (15972686)
2005
19
Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. (16051851)
2005
20
Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (16249483)
2005
21
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
22
Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis. (15585885)
2004
23
In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. (12766053)
2003
24
Microsporidial stromal keratitis. (12860813)
2003
25
Therapeutic vaccination with vhs(-) herpes simplex virus reduces the severity of recurrent herpetic stromal keratitis in mice. (12237416)
2002
26
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. (12421973)
2002
27
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
28
Cytokine expression in murine corneas during recurrent herpetic stromal keratitis. (11815888)
2001
29
Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (10922194)
2000
30
Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells. (10937573)
2000
31
Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice. (10208930)
1999
32
Control of herpetic stromal keratitis using CTLA4Ig fusion protein. (9434800)
1998
33
On the essential involvement of neutrophils in the immunopathologic disease: herpetic stromal keratitis. (9013983)
1997
34
Immunologic, histologic, and virologic features of herpesvirus-induced stromal keratitis in cats. (7695149)
1995
35
Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. (7561104)
1995
36
Stromal keratitis induced by a unique clinical isolate of herpes simplex virus type 1. (8065701)
1994
37
The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice. (7958034)
1994
38
Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. (8051423)
1994
39
Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. (7997323)
1994
40
Passive transfer of anti-herpes simplex virus type 2 monoclonal and polyclonal antibodies protect against herpes simplex virus type 1-induced but not herpes simplex virus type 2-induced stromal keratitis. (8392037)
1993
41
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
42
Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. (1357034)
1992
43
Obstinate cases of stromal keratitis treated by combined traditional Chinese and Western medicine. (1453751)
1992
44
The effect of flurbiprofen on herpes simplex virus type 1 stromal keratitis in mice. (2167299)
1990
45
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
46
Quantitation of purified monoclonal antibody needed to prevent HSV-1 induced stromal keratitis in mice. (2736955)
1989
47
Herpetic stromal keratitis in congenital dysgammaglobulinemia. Case report. (2714093)
1989
48
Clinical, pathologic, and immunopathologic characteristics of experimental murine herpes simplex virus stromal keratitis and uveitis is controlled by gene products from the Igh-1 locus on chromosome 12. (3128902)
1987
49
Stromal keratitis complicating anterior membrane dystrophy. (3874550)
1985
50
Herpetic stromal keratitis-evidence for cell-mediated immunopathogenesis. (187060)
1976

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stromal Keratitis

Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 55R&D Systems, 54QIAGEN, 31KEGG
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Pathways related to Stromal Keratitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TNFSF4, IL2RA
2
Show member pathways
9.8IL17A, IL17RA
3
Show member pathways
9.8IL17A, IL17RA
4
Show member pathways
9.3IL1RAP, IL17RA, IL17A
5
Show member pathways
9.2IL2RA, IL1RAP, CIITA
6
Show member pathways
9.0IL2RA, CCR6, CCL20, TNFSF4
7
Show member pathways
9.0CCL20, TNFSF4, CCR6, IL2RA
8
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.8IL1RAP, TRB, CCL20
9
Show member pathways
7.7CCR6, TNFSF4, CCL20, IL2RA, IL17A, IL17RA

Compounds for genes affiliated with Stromal Keratitis

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 3BitterDB, 25HMDB, 62Tocris Bioscience
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Compounds related to Stromal Keratitis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1mip-3alpha4610.1CCR6, CCL20
2larc4610.0CCR6, CCL20
3ecori469.8TRB, CIITA
4enterotoxin469.8CIITA, TRB
5ccl446 3010.7IL17A, CCR6, CCL20
6peptidoglycan46 3010.6CCL20, CIITA
7tuberculin469.6CD69, IL2RA
8infliximab46 52 1211.6IL17A, IL2RA
9l-nmma469.6IL17A, IL1RAP
10endotoxin469.6CIITA, CCL20, IL17A
11phorbol 12,13-dibutyrate469.5CD69, IL2RA
12con a469.4CD69, IL2RA
13methimazole46 3 1211.4IL2RA, CD69
14tarc469.4CCR6, CCL20
15mannose469.3CD69, IL17A, CIITA
16poly(i-c)469.2CD69, CCL20
17ionomycin469.2CD69, IL17A, IL2RA
18tacrolimus46 52 1211.2IL2RA, IL17A, CD69
19allergens469.2CIITA, CCL20, CD69
20methotrexate52 46 1211.2IL2RA, IL17A, CD69
21vegf469.1IL17A, IL2RA, CCR6, CCL20
22actinomycin d469.0CD69, IL17A, CIITA
23phorbol469.0IL2RA, CD69, TRB
24thymidine46 259.9CD69, IL17A, IL2RA, CIITA
25oligonucleotide468.9TRB, IL17A, CCL20, CIITA
26creatinine468.8IL2RA, IL17A, LCN1, CD69
27phosphatidylinositol468.7CIITA, IL2RA, IL17A, CD69
28rantes468.6IL17RA, IL17A, IL2RA, CCR6, CCL20, CIITA
29lipid468.5CIITA, CCR6, IL17A, LCN1, CD69
30pge2468.4CIITA, IL2RA, IL17A, IL1RAP, CD69
31cyclosporin a46 30 6210.3CIITA, IL2RA, IL17A, CD69, TRB
32nitric oxide46 25 1210.3CD69, IL1RAP, IL17A, CCL20, CIITA
33dexamethasone46 52 30 1210.9CIITA, CCL20, IL2RA, IL17A, IL1RAP, CD69
34tyrosine467.8CIITA, IL2RA, IL17A, IL1RAP, CD69, TRB
35calcium46 52 25 1210.7CIITA, CCL20, CCR6, LCN1, CD69, TRB

GO Terms for genes affiliated with Stromal Keratitis

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17Gene Ontology
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Cellular components related to Stromal Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.6CIITA, TNFSF4, AIMP1
2extracellular spaceGO:0056158.6LCN1, IL17A, CCL20, TNFSF4, AIMP1
3external side of plasma membraneGO:0098978.6CD69, IL17A, IL2RA
4integral component of plasma membraneGO:0058878.1TNFSF4, CCR6, IL17RA, IL1RAP, CD69

Biological processes related to Stromal Keratitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:0725379.9IL17RA, IL17A
2positive regulation of interleukin-23 productionGO:0327479.9IL17A, IL17RA
3positive regulation of cytokine production involved in inflammatory responseGO:19000179.8IL17RA, IL17A
4positive regulation of activated T cell proliferationGO:0421049.5IL2RA, TNFSF4
5cell-cell signalingGO:0072679.3IL17A, CCL20, AIMP1
6chemotaxisGO:0069359.3AIMP1, CCL20, CCR6
7inflammatory responseGO:0069548.6AIMP1, CIITA, CCL20, IL17A, IL1RAP
8signal transductionGO:0071658.3CD69, CCR6, CCL20, TNFSF4, AIMP1
9immune responseGO:0069557.9IL1RAP, IL17A, IL2RA, CCR6, CCL20, CIITA

Molecular functions related to Stromal Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.6IL17A, TNFSF4, AIMP1

Products for genes affiliated with Stromal Keratitis

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Sources for Stromal Keratitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet