MCID: STR072
MIFTS: 43

Stromal Keratitis malady

Eye diseases, Rare diseases categories
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Summaries for Stromal Keratitis

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MalaCards based summary: Stromal Keratitis is related to keratitis and uveitis. An important gene associated with Stromal Keratitis is AIMP1 (aminoacyl tRNA synthetase complex-interacting multifunctional protein 1), and among its related pathways are TSLP Signaling Pathway and Cytokine production by Th17 cells in CF. The compounds mip-3alpha and larc have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Stromal Keratitis

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Stromal Keratitis, Aliases & Descriptions:

Name: Stromal Keratitis 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 48 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

48
stromal keratitis:
Prevalence: 1-5/10000


External Ids:

ICD10 via Orphanet26 H16.3
UMLS via Orphanet63 C1318020

Related Diseases for Stromal Keratitis

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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis32.3IL17A
2uveitis30.2IL2RA, IL17A, CD69
3herpes simplex10.9
4eye disease10.4
5endotheliitis10.4
6thyroiditis10.3CIITA
7corneal neovascularization10.3
8adult t-cell leukemia10.3IL2RA, TRB
9relapsing-remitting multiple sclerosis10.3IL2RA, TRB
10sezary's disease10.3IL2RA, TRB
11pulmonary sarcoidosis10.2IL2RA, TRB
12iritis10.2
13herpes zoster10.2
14peripheral t-cell lymphoma10.2IL2RA, TRB
15juvenile rheumatoid arthritis10.2IL2RA, TRB
16kawasaki disease10.2TRB, CIITA
17hypereosinophilic syndrome10.2IL2RA, CD69
18mastocytosis10.2CD69, IL2RA
19mycosis fungoides10.2TRB, IL2RA
20pleurisy10.2LCN1, IL2RA, TRB
21toxic shock syndrome10.2CD69, CIITA
22cutaneous t cell lymphoma10.2IL2RA, TRB
23graft versus host disease10.1IL2RA, TRB
24thymoma10.1TRB, CD69
25demyelinating disease10.1TRB, IL17A
26non-hodgkin lymphoma10.1CCR6, IL2RA, TRB
27lyme disease10.1
28b cell deficiency10.1
29corneal edema10.1
30dysgammaglobulinemia10.1
31iridocyclitis10.1
32scleritis10.1
33anterior uveitis10.1
34herpes zoster ophthalmicus10.1
35blindness10.1
36celiac disease10.1CIITA, TRB
37sarcoidosis10.1IL2RA, TRB, CD69
38lymphopenia10.1CIITA, IL2RA
39lupus nephritis10.1CIITA, IL2RA
40autoimmune thyroiditis10.0IL2RA, CIITA
41connective tissue disease10.0CD69, IL2RA
42type 1 diabetes mellitus10.0CIITA, TRB, CD69
43vasculitis10.0TNFSF4, TRB, IL17A
44severe combined immunodeficiency10.0TRB, CIITA, IL2RA
45sjogren's syndrome10.0IL2RA, CIITA, TRB
46myeloma10.0CIITA, CCR6, TRB
47immunodeficiency with hyper igm type 210.0CCR6, CIITA, CD69
48colitis10.0IL17A, CCL20, IL17RA
49tetanus10.0CIITA, IL2RA, CD69
50cystic fibrosis9.9IL17A, TRB, CCL20

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms for Stromal Keratitis

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Drugs & Therapeutics for Stromal Keratitis

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Drug clinical trials:

Search ClinicalTrials for Stromal Keratitis

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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MalaCards organs/tissues related to Stromal Keratitis:

32
Eye, T cells, Endothelial, Neutrophil, Lymph node, Skin, B cells

Animal Models for Stromal Keratitis or affiliated genes

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MGI Mouse Phenotypes related to Stromal Keratitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.0CIITA, CCR6, IL2RA, IL17A, IL17RA, CD69
2MP:00053875.9TRB, AIMP1, TNFSF4, CIITA, CCR6, IL2RA

Publications for Stromal Keratitis

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Articles related to Stromal Keratitis:

(show top 50)    (show all 188)
idTitleAuthorsYear
1
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. (24651695)
2014
2
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
3
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
4
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
5
Elevated intraocular pressure-induced interlamellar stromal keratitis occurring 9 years after laser in situ keratomileusis. (21941173)
2012
6
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
7
Recurrent herpetic stromal keratitis in mice: a model for studying human HSK. (22593769)
2012
8
Intraocular invasion by microsporidial spores in a case of stromal keratitis. (21482880)
2011
9
A crucial role for B and T lymphocyte attenuator in preventing the development of CD4+ T cell-mediated herpetic stromal keratitis. (21042564)
2010
10
Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis. (19204233)
2009
11
Amniotic membrane transplantation induces apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis. (19255156)
2009
12
Management of herpes simplex virus stromal keratitis: an evidence-based review. (19298901)
2009
13
Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis. (18689698)
2008
14
Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. (18580272)
2008
15
Interferon gamma is not required for recurrent herpetic stromal keratitis. (18755490)
2008
16
Granulocyte macrophage colony-stimulating factor expression in human herpetic stromal keratitis: implications for the role of neutrophils in HSK. (17197544)
2007
17
Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. (16997857)
2006
18
Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects. (16951377)
2006
19
Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines. (16178874)
2005
20
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. (15972686)
2005
21
Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. (16051851)
2005
22
Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (16249483)
2005
23
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
24
Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis. (15585885)
2004
25
In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. (12766053)
2003
26
Microsporidial stromal keratitis. (12860813)
2003
27
Therapeutic vaccination with vhs(-) herpes simplex virus reduces the severity of recurrent herpetic stromal keratitis in mice. (12237416)
2002
28
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. (12421973)
2002
29
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
30
Cytokine expression in murine corneas during recurrent herpetic stromal keratitis. (11815888)
2001
31
Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (10922194)
2000
32
Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells. (10937573)
2000
33
Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice. (10208930)
1999
34
On the essential involvement of neutrophils in the immunopathologic disease: herpetic stromal keratitis. (9013983)
1997
35
Immunologic, histologic, and virologic features of herpesvirus-induced stromal keratitis in cats. (7695149)
1995
36
Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. (7561104)
1995
37
Stromal keratitis induced by a unique clinical isolate of herpes simplex virus type 1. (8065701)
1994
38
The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice. (7958034)
1994
39
Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. (8051423)
1994
40
Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. (7997323)
1994
41
Passive transfer of anti-herpes simplex virus type 2 monoclonal and polyclonal antibodies protect against herpes simplex virus type 1-induced but not herpes simplex virus type 2-induced stromal keratitis. (8392037)
1993
42
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
43
Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. (1357034)
1992
44
Obstinate cases of stromal keratitis treated by combined traditional Chinese and Western medicine. (1453751)
1992
45
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
46
Quantitation of purified monoclonal antibody needed to prevent HSV-1 induced stromal keratitis in mice. (2736955)
1989
47
Herpetic stromal keratitis in congenital dysgammaglobulinemia. Case report. (2714093)
1989
48
Clinical, pathologic, and immunopathologic characteristics of experimental murine herpes simplex virus stromal keratitis and uveitis is controlled by gene products from the Igh-1 locus on chromosome 12. (3128902)
1987
49
Stromal keratitis complicating anterior membrane dystrophy. (3874550)
1985
50
Herpetic stromal keratitis-evidence for cell-mediated immunopathogenesis. (187060)
1976

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Expression patterns in normal tissues for genes affiliated with Stromal Keratitis

Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Pathways related to Stromal Keratitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2RA, TNFSF4
2
Show member pathways
9.8IL17RA, IL17A
3
Show member pathways
9.8IL17RA, IL17A
4
Show member pathways
9.3IL17A, IL17RA, IL1RAP
5
Show member pathways
9.2CIITA, IL2RA, IL1RAP
6
Show member pathways
9.0TNFSF4, CCL20, CCR6, IL2RA
7
Show member pathways
9.0TNFSF4, CCL20, CCR6, IL2RA
8
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.8TRB, IL1RAP, CCL20
9
Show member pathways
7.7IL1RAP, IL17RA, IL17A, IL2RA, CCR6, CCL20

Compounds for genes affiliated with Stromal Keratitis

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Compounds related to Stromal Keratitis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1mip-3alpha4410.1CCR6, CCL20
2larc4410.0CCR6, CCL20
3ecori449.8TRB, CIITA
4enterotoxin449.8CIITA, TRB
5ccl444 2810.7IL17A, CCR6, CCL20
6peptidoglycan44 2810.6CCL20, CIITA
7tuberculin449.6CD69, IL2RA
8infliximab44 50 1111.6IL17A, IL2RA
9l-nmma449.6IL17A, IL1RAP
10endotoxin449.6CIITA, CCL20, IL17A
11phorbol 12,13-dibutyrate449.5CD69, IL2RA
12con a449.4CD69, IL2RA
13methimazole44 2 1111.4IL2RA, CD69
14tarc449.4CCR6, CCL20
15mannose449.3CD69, IL17A, CIITA
16poly(i-c)449.2CD69, CCL20
17ionomycin449.2CD69, IL17A, IL2RA
18tacrolimus44 50 1111.2IL2RA, IL17A, CD69
19allergens449.2CIITA, CCL20, CD69
20methotrexate50 44 1111.2IL2RA, IL17A, CD69
21vegf449.1IL17A, IL2RA, CCR6, CCL20
22actinomycin d449.0CD69, IL17A, CIITA
23phorbol449.0IL2RA, CD69, TRB
24thymidine44 249.9CD69, IL17A, IL2RA, CIITA
25oligonucleotide448.9TRB, IL17A, CCL20, CIITA
26creatinine448.8IL2RA, IL17A, LCN1, CD69
27phosphatidylinositol448.7CIITA, IL2RA, IL17A, CD69
28rantes448.6IL17RA, IL17A, IL2RA, CCR6, CCL20, CIITA
29lipid448.5CIITA, CCR6, IL17A, LCN1, CD69
30pge2448.4CIITA, IL2RA, IL17A, IL1RAP, CD69
31cyclosporin a44 28 6110.3CIITA, IL2RA, IL17A, CD69, TRB
32nitric oxide44 24 1110.3CD69, IL1RAP, IL17A, CCL20, CIITA
33dexamethasone44 50 28 1110.9CIITA, CCL20, IL2RA, IL17A, IL1RAP, CD69
34tyrosine447.8CIITA, IL2RA, IL17A, IL1RAP, CD69, TRB
35calcium44 50 24 1110.7CIITA, CCL20, CCR6, LCN1, CD69, TRB

GO Terms for genes affiliated with Stromal Keratitis

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Cellular components related to Stromal Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.6CIITA, TNFSF4, AIMP1
2extracellular spaceGO:0056158.6LCN1, IL17A, CCL20, TNFSF4, AIMP1
3external side of plasma membraneGO:0098978.6CD69, IL17A, IL2RA
4integral component of plasma membraneGO:0058878.1TNFSF4, CCR6, IL17RA, IL1RAP, CD69

Biological processes related to Stromal Keratitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:0725379.9IL17RA, IL17A
2positive regulation of interleukin-23 productionGO:0327479.9IL17A, IL17RA
3positive regulation of cytokine production involved in inflammatory responseGO:19000179.8IL17RA, IL17A
4positive regulation of activated T cell proliferationGO:0421049.5IL2RA, TNFSF4
5cell-cell signalingGO:0072679.3IL17A, CCL20, AIMP1
6chemotaxisGO:0069359.3AIMP1, CCL20, CCR6
7inflammatory responseGO:0069548.6AIMP1, CIITA, CCL20, IL17A, IL1RAP
8signal transductionGO:0071658.3CD69, CCR6, CCL20, TNFSF4, AIMP1
9immune responseGO:0069557.9IL1RAP, IL17A, IL2RA, CCR6, CCL20, CIITA

Molecular functions related to Stromal Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.6IL17A, TNFSF4, AIMP1

Products for genes affiliated with Stromal Keratitis

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Sources for Stromal Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet