MCID: STR072
MIFTS: 37

Stromal Keratitis malady

Eye diseases, Rare diseases categories

Summaries for Stromal Keratitis

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MalaCards based summary: Stromal Keratitis is related to keratitis and uveitis. An important gene associated with Stromal Keratitis is AIMP1 (aminoacyl tRNA synthetase complex-interacting multifunctional protein 1), and among its related pathways are TSLP Signaling Pathway and Cytokine production by Th17 cells in CF. The compounds mip-3alpha and larc have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Stromal Keratitis

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Stromal Keratitis, Aliases & Descriptions:

Name: Stromal Keratitis 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 47 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

47
stromal keratitis:
Prevalence: 1-5/10000 (Europe)


External Ids:

Orphanet47 137599
ICD10 via Orphanet26 H16.3
UMLS via Orphanet61 C1318020

Related Diseases for Stromal Keratitis

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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis32.3IL17A
2uveitis30.1IL2RA, IL17A, CD69
3herpes simplex10.9
4eye disease10.4
5endotheliitis10.4
6thyroiditis10.3CIITA
7corneal neovascularization10.3
8adult t-cell leukemia10.3IL2RA, TRB
9relapsing-remitting multiple sclerosis10.3IL2RA, TRB
10sezary's disease10.2IL2RA, TRB
11iritis10.2
12blindness10.2
13pulmonary sarcoidosis10.2IL2RA, TRB
14peripheral t-cell lymphoma10.2IL2RA, TRB
15juvenile rheumatoid arthritis10.2IL2RA, TRB
16kawasaki disease10.2TRB, CIITA
17hypereosinophilic syndrome10.2IL2RA, CD69
18mastocytosis10.2CD69, IL2RA
19mycosis fungoides10.2TRB, IL2RA
20pleurisy10.2LCN1, IL2RA, TRB
21cutaneous t cell lymphoma10.1IL2RA, TRB
22toxic shock syndrome10.1CD69, CIITA
23graft-versus-host disease, protection against10.1IL2RA, TRB
24thymoma10.1TRB, CD69
25demyelinating disease10.1TRB, IL17A
26lyme disease10.1
27herpes zoster10.1
28b cell deficiency10.1
29corneal edema10.1
30dysgammaglobulinemia10.1
31scleritis10.1
32anterior uveitis10.1
33herpes zoster ophthalmicus10.1
34lymphoma, non-hodgkin10.1CCR6, IL2RA, TRB
35celiac disease10.1CIITA, TRB
36lymphopenia10.1CIITA, IL2RA
37sarcoidosis 110.1IL2RA, TRB, CD69
38lupus nephritis10.1CIITA, IL2RA
39hashimoto thyroiditis10.0IL2RA, CIITA
40connective tissue disease10.0CD69, IL2RA
41diabetes mellitus, insulin-dependent10.0CIITA, TRB, CD69
42vasculitis10.0TNFSF4, TRB, IL17A
43severe combined immunodeficiency10.0TRB, CIITA, IL2RA
44myeloma10.0CIITA, CCR6, TRB
45sjogren's syndrome10.0IL2RA, CIITA, TRB
46hiv-110.0CCR6, CIITA, CD69
47colitis10.0IL17A, CCL20, IL17RA
48tetanus9.9CIITA, IL2RA, CD69
49cystic fibrosis9.9IL17A, TRB, CCL20
50galactosemia9.9CCR6, CCL20, IL17A

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms for Stromal Keratitis

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Drugs & Therapeutics for Stromal Keratitis

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Drug clinical trials:

Search ClinicalTrials for Stromal Keratitis

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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MalaCards organs/tissues related to Stromal Keratitis:

31
Eye, T cells, Endothelial, Neutrophil, Lymph node, Skin, B cells

Animal Models for Stromal Keratitis or affiliated genes

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MGI Mouse Phenotypes related to Stromal Keratitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.0CIITA, CCR6, IL2RA, IL17A, IL17RA, CD69
2MP:00053875.9TRB, AIMP1, TNFSF4, CIITA, CCR6, IL2RA

Publications for Stromal Keratitis

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Articles related to Stromal Keratitis:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia. (25826328)
2015
2
Microsporidial stromal keratitis masquerading as acute graft rejection. (25533000)
2015
3
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. (25859798)
2015
4
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. (24651695)
2014
5
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
6
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
7
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
8
Elevated intraocular pressure-induced interlamellar stromal keratitis occurring 9 years after laser in situ keratomileusis. (21941173)
2012
9
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
10
Recurrent herpetic stromal keratitis in mice: a model for studying human HSK. (22593769)
2012
11
Intraocular invasion by microsporidial spores in a case of stromal keratitis. (21482880)
2011
12
A crucial role for B and T lymphocyte attenuator in preventing the development of CD4+ T cell-mediated herpetic stromal keratitis. (21042564)
2010
13
Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis. (19204233)
2009
14
Amniotic membrane transplantation induces apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis. (19255156)
2009
15
Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis. (18689698)
2008
16
Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. (18580272)
2008
17
Interferon gamma is not required for recurrent herpetic stromal keratitis. (18755490)
2008
18
Granulocyte macrophage colony-stimulating factor expression in human herpetic stromal keratitis: implications for the role of neutrophils in HSK. (17197544)
2007
19
Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. (16997857)
2006
20
Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines. (16178874)
2005
21
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. (15972686)
2005
22
Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. (16051851)
2005
23
Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (16249483)
2005
24
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
25
Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis. (15585885)
2004
26
In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. (12766053)
2003
27
Microsporidial stromal keratitis. (12860813)
2003
28
Therapeutic vaccination with vhs(-) herpes simplex virus reduces the severity of recurrent herpetic stromal keratitis in mice. (12237416)
2002
29
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. (12421973)
2002
30
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
31
Cytokine expression in murine corneas during recurrent herpetic stromal keratitis. (11815888)
2001
32
Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (10922194)
2000
33
Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells. (10937573)
2000
34
Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice. (10208930)
1999
35
Control of herpetic stromal keratitis using CTLA4Ig fusion protein. (9434800)
1998
36
Immunologic, histologic, and virologic features of herpesvirus-induced stromal keratitis in cats. (7695149)
1995
37
Stromal keratitis induced by a unique clinical isolate of herpes simplex virus type 1. (8065701)
1994
38
The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice. (7958034)
1994
39
Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. (8051423)
1994
40
Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. (7997323)
1994
41
Passive transfer of anti-herpes simplex virus type 2 monoclonal and polyclonal antibodies protect against herpes simplex virus type 1-induced but not herpes simplex virus type 2-induced stromal keratitis. (8392037)
1993
42
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
43
Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. (1357034)
1992
44
Obstinate cases of stromal keratitis treated by combined traditional Chinese and Western medicine. (1453751)
1992
45
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
46
Quantitation of purified monoclonal antibody needed to prevent HSV-1 induced stromal keratitis in mice. (2736955)
1989
47
Herpetic stromal keratitis in congenital dysgammaglobulinemia. Case report. (2714093)
1989
48
Clinical, pathologic, and immunopathologic characteristics of experimental murine herpes simplex virus stromal keratitis and uveitis is controlled by gene products from the Igh-1 locus on chromosome 12. (3128902)
1987
49
Stromal keratitis complicating anterior membrane dystrophy. (3874550)
1985
50
Herpetic stromal keratitis-evidence for cell-mediated immunopathogenesis. (187060)
1976

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2RA, TNFSF4
2
Show member pathways
9.8IL17RA, IL17A
3
Show member pathways
9.8IL17RA, IL17A
4
Show member pathways
9.3IL17A, IL17RA, IL1RAP
5
Show member pathways
9.2CIITA, IL2RA, IL1RAP
6
Show member pathways
9.0TNFSF4, CCL20, CCR6, IL2RA
7
Show member pathways
9.0TNFSF4, CCL20, CCR6, IL2RA
8
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.8TRB, IL1RAP, CCL20
9
Show member pathways
7.7IL1RAP, IL17RA, IL17A, IL2RA, CCR6, CCL20

Compounds for genes affiliated with Stromal Keratitis

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Compounds related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1mip-3alpha4310.1CCR6, CCL20
2larc4310.0CCR6, CCL20
3ecori439.8TRB, CIITA
4enterotoxin439.8CIITA, TRB
5ccl443 2810.7IL17A, CCR6, CCL20
6peptidoglycan43 2810.6CCL20, CIITA
7tuberculin439.6CD69, IL2RA
8infliximab43 49 1211.6IL17A, IL2RA
9l-nmma439.6IL17A, IL1RAP
10endotoxin439.6CIITA, CCL20, IL17A
11phorbol 12,13-dibutyrate439.5CD69, IL2RA
12con a439.4CD69, IL2RA
13methimazole43 2 1211.4IL2RA, CD69
14tarc439.4CCR6, CCL20
15mannose439.3CD69, IL17A, CIITA
16poly(i-c)439.2CD69, CCL20
17ionomycin439.2CD69, IL17A, IL2RA
18tacrolimus43 49 1211.2IL2RA, IL17A, CD69
19allergens439.2CIITA, CCL20, CD69
20methotrexate49 43 1211.2IL2RA, IL17A, CD69
21vegf439.1IL17A, IL2RA, CCR6, CCL20
22actinomycin d439.0CD69, IL17A, CIITA
23phorbol439.0IL2RA, CD69, TRB
24thymidine43 249.9CD69, IL17A, IL2RA, CIITA
25oligonucleotide438.9TRB, IL17A, CCL20, CIITA
26creatinine438.8IL2RA, IL17A, LCN1, CD69
27phosphatidylinositol438.7CIITA, IL2RA, IL17A, CD69
28rantes438.6IL17RA, IL17A, IL2RA, CCR6, CCL20, CIITA
29lipid438.5CIITA, CCR6, IL17A, LCN1, CD69
30pge2438.4CIITA, IL2RA, IL17A, IL1RAP, CD69
31cyclosporin a43 28 5910.3CIITA, IL2RA, IL17A, CD69, TRB
32nitric oxide43 24 1210.3CD69, IL1RAP, IL17A, CCL20, CIITA
33dexamethasone43 49 28 1210.9CIITA, CCL20, IL2RA, IL17A, IL1RAP, CD69
34tyrosine437.8CIITA, IL2RA, IL17A, IL1RAP, CD69, TRB
35calcium43 49 24 1210.7CIITA, CCL20, CCR6, LCN1, CD69, TRB

GO Terms for genes affiliated with Stromal Keratitis

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Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.6CIITA, TNFSF4, AIMP1
2extracellular spaceGO:00056158.6LCN1, IL17A, CCL20, TNFSF4, AIMP1
3external side of plasma membraneGO:00098978.6CD69, IL17A, IL2RA
4integral component of plasma membraneGO:00058878.1TNFSF4, CCR6, IL17RA, IL1RAP, CD69

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:00725379.9IL17RA, IL17A
2positive regulation of interleukin-23 productionGO:00327479.9IL17A, IL17RA
3positive regulation of cytokine production involved in inflammatory responseGO:019000179.8IL17RA, IL17A
4positive regulation of activated T cell proliferationGO:00421049.5IL2RA, TNFSF4
5cell-cell signalingGO:00072679.3IL17A, CCL20, AIMP1
6chemotaxisGO:00069359.3AIMP1, CCL20, CCR6
7inflammatory responseGO:00069548.6AIMP1, CIITA, CCL20, IL17A, IL1RAP
8signal transductionGO:00071658.3CD69, CCR6, CCL20, TNFSF4, AIMP1
9immune responseGO:00069557.9IL1RAP, IL17A, IL2RA, CCR6, CCL20, CIITA

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.6IL17A, TNFSF4, AIMP1

Products for genes affiliated with Stromal Keratitis

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Sources for Stromal Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet