MCID: STR072
MIFTS: 36

Stromal Keratitis malady

Eye diseases, Rare diseases categories

Aliases & Classifications for Stromal Keratitis

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Stromal Keratitis:

Name: Stromal Keratitis 51 65


Classifications:

Orphanet: 51 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

51
stromal keratitis:
Prevalence: 1-5/10000 (Europe)


External Ids:

Orphanet51 137599
ICD10 via Orphanet28 H16.3
UMLS via Orphanet66 C1318020

Summaries for Stromal Keratitis

About this section
MalaCards based summary: Stromal Keratitis is related to keratitis and endotheliitis. An important gene associated with Stromal Keratitis is PAX6 (Paired Box 6), and among its related pathways are Th1 Differentiation and Hematopoietic cell lineage. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Related Diseases for Stromal Keratitis

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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis31.5CCL2, IL17A, IL6, PAX6, TNF
2endotheliitis27.4AIMP1, CCL2, CCL20, CCL3, CCR6, CD69
3herpes simplex10.9
4eye disease10.4
5corneal neovascularization10.4
6stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.3CIITA, TNF
7intracranial primitive neuroectodermal tumor10.2IL2RA, TNF
8iritis10.2
9herpes zoster10.2
10uveitis10.2
11neonatal thyrotoxicosis10.2IL2RA, TNF, TRB
12autoimmune gastrointestinal dysmotility10.2IL17A, IL2RA
13pyknoachondrogenesis10.2CCL20, CCR6, TNF
14fibrogenesis imperfecta ossium10.1CCL2, IL2RA, TNF
15renal oncocytoma10.1CCL2, IL2RA, TNF
16brachial plexus neuritis10.1CCL2, IL17A, TNF
17keratopathy10.1
18lyme disease10.1
19b cell deficiency10.1
20corneal edema10.1
21dysgammaglobulinemia10.1
22iridocyclitis10.1
23scleritis10.1
24anterior uveitis10.1
25herpes zoster ophthalmicus10.1
26siderosis10.1CCL2, TNF
27vagina botryoid rhabdomyosarcoma10.0CCL2, IL17A, IL2RA, TNF
28crohn's disease10.0IL6, TNF
29scleroderma10.0CCL2, TNF
30aorta atresia10.0IL6, TNF
31plantar nerve lesion10.0IL6, TNF
32neuroendocrine tumor10.0CCL2, CXCL10, TNF
33treponema infection10.0IL17A, IL6, TNF
34tuberculous uveitis10.0CCL2, CCL3, TNF
35malignant sertoli-leydig cell tumor of ovary10.0IL6, TNF
36kartagener syndrome10.0IL17A, IL6, TNF
37diversion colitis10.0IL17A, IL6, TNF
38eye accommodation disease10.0IL17A, IL6, TNF
39ectropion10.0IL17A, IL6, TNF
40spotted fever10.0IL17A, IL6, TNF
41idiopathic spinal cord herniation10.0IL2RA, IL6, TNF
42larynx sarcoma10.0IL6, TNF
43bronchopulmonary dysplasia10.0IL17A, IL6, TNF
44emery-dreifuss muscular dystrophy10.0IL17A, IL6, TNF
45glycogen storage disease viii10.0IL6, TNF
46chronic inflammatory demyelinating polyradiculoneuropathy10.0IL2RA, IL6, TNF
47de quervain disease10.0CIITA, IL6, TNF
48lacrimal gland adenocarcinoma9.9IL6, LCN1, TNF
49periodontitis9.9IL17A, IL6, TNF
50sarcoidosis 19.9CCL2, CCL3, IL2RA, TNF

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms for Stromal Keratitis

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Drugs & Therapeutics for Stromal Keratitis

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Drugs for Stromal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PrednisoloneapprovedPhase 3103350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
2
MethylprednisoloneapprovedPhase 3103383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
3AcyclovirPhase 3149
4Prednisolone phosphatePhase 31033
5Prednisolone acetatePhase 31033
6Prednisolone hemisuccinatePhase 31033
7Methylprednisolone HemisuccinatePhase 31033
8Methylprednisolone acetatePhase 31033
9
Riboflavinapproved, nutraceutical13883-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
Hyre
Lactobene
 
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavin
Riboflavin phosphate sodium dihydrate
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
e101
10
Folic Acidapproved, nutraceutical285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
11Vitamin B Complex2775
12Vitamin B9Nutraceutical2851
13Vitamin B2Nutraceutical138
14FolateNutraceutical2851

Interventional clinical trials:

idNameStatusNCT IDPhase
1Herpetic Eye Disease Study (HEDS) IICompletedNCT00000139Phase 3
2Herpetic Eye Disease Study (HEDS) IActive, not recruitingNCT00000138Phase 3
3Cross Linking for Treatment of Corneal InfectionTerminatedNCT00912509

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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MalaCards organs/tissues related to Stromal Keratitis:

33
Eye, T cells, Endothelial, Neutrophil, B cells, Lymph node, Skin

Animal Models for Stromal Keratitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Stromal Keratitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8CCL2, IL17RA, IL6, PAX6, TNF, TRB
2MP:00053818.3CCL2, CCL3, IL17A, IL2RA, IL6, PAX6
3MP:00053766.7AIMP1, CCL2, CCL3, CCR6, CIITA, CXCL10
4MP:00053976.1CCL2, CCL3, CCR6, CD69, CIITA, CXCL10
5MP:00053874.9AIMP1, CCL2, CCL3, CCR6, CD69, CIITA

Publications for Stromal Keratitis

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Articles related to Stromal Keratitis:

(show top 50)    (show all 206)
idTitleAuthorsYear
1
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia. (25826328)
2015
2
Idiopathic stromal keratitis resembling central toxic keratopathy. (26210054)
2015
3
Intrastromal bevacizumab injection for corneal neovascularization in herpetic stromal keratitis. (26342658)
2015
4
Microsporidial stromal keratitis masquerading as acute graft rejection. (25533000)
2015
5
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. (25859798)
2015
6
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. (24651695)
2014
7
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
8
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
9
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
10
Elevated intraocular pressure-induced interlamellar stromal keratitis occurring 9 years after laser in situ keratomileusis. (21941173)
2012
11
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
12
Recurrent herpetic stromal keratitis in mice: a model for studying human HSK. (22593769)
2012
13
Intraocular invasion by microsporidial spores in a case of stromal keratitis. (21482880)
2011
14
A crucial role for B and T lymphocyte attenuator in preventing the development of CD4+ T cell-mediated herpetic stromal keratitis. (21042564)
2010
15
Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis. (19204233)
2009
16
Amniotic membrane transplantation induces apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis. (19255156)
2009
17
Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis. (18689698)
2008
18
Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. (18580272)
2008
19
Interferon gamma is not required for recurrent herpetic stromal keratitis. (18755490)
2008
20
Granulocyte macrophage colony-stimulating factor expression in human herpetic stromal keratitis: implications for the role of neutrophils in HSK. (17197544)
2007
21
Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. (16997857)
2006
22
Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines. (16178874)
2005
23
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. (15972686)
2005
24
Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. (16051851)
2005
25
Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (16249483)
2005
26
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
27
Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis. (15585885)
2004
28
In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. (12766053)
2003
29
Microsporidial stromal keratitis. (12860813)
2003
30
Therapeutic vaccination with vhs(-) herpes simplex virus reduces the severity of recurrent herpetic stromal keratitis in mice. (12237416)
2002
31
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. (12421973)
2002
32
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
33
Cytokine expression in murine corneas during recurrent herpetic stromal keratitis. (11815888)
2001
34
Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (10922194)
2000
35
Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells. (10937573)
2000
36
Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice. (10208930)
1999
37
Control of herpetic stromal keratitis using CTLA4Ig fusion protein. (9434800)
1998
38
Stromal keratitis induced by a unique clinical isolate of herpes simplex virus type 1. (8065701)
1994
39
The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice. (7958034)
1994
40
Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. (8051423)
1994
41
Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. (7997323)
1994
42
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
43
Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. (1357034)
1992
44
Obstinate cases of stromal keratitis treated by combined traditional Chinese and Western medicine. (1453751)
1992
45
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
46
Quantitation of purified monoclonal antibody needed to prevent HSV-1 induced stromal keratitis in mice. (2736955)
1989
47
Herpetic stromal keratitis in congenital dysgammaglobulinemia. Case report. (2714093)
1989
48
Clinical, pathologic, and immunopathologic characteristics of experimental murine herpes simplex virus stromal keratitis and uveitis is controlled by gene products from the Igh-1 locus on chromosome 12. (3128902)
1987
49
Stromal keratitis complicating anterior membrane dystrophy. (3874550)
1985
50
Herpetic stromal keratitis-evidence for cell-mediated immunopathogenesis. (187060)
1976

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IL17A, IL6, TNF
29.6IL2RA, IL6, TNF
3
Show member pathways
9.6IL17A, IL17RA, IL6
49.6IL6, TNF, TRB
59.5IL1RAP, TNF, TRB
6
Show member pathways
9.5CCL3, IL2RA, TNF
7
Show member pathways
9.5CCL2, IL6, TNF
89.5CCL2, IL6, TNF
99.5IL2RA, IL6, TNFSF4
109.4CCL2, CCL3, TNF
11
Show member pathways
9.3CCL2, IL17A, IL6, TNF
129.2CCL2, CXCL10, IL6, TNF
13
Show member pathways
9.1IL17A, IL17RA, IL1RAP, IL6
14
Show member pathways
9.1CIITA, IL17A, IL2RA, IL6, TNF
15
Show member pathways
8.7CCL2, CIITA, CXCL10, IL2RA, IL6, TNF
168.6CCL2, CCL20, CXCL10, IL6, TNF
17
Show member pathways
8.6CCL2, CCL3, CXCL10, IL6, TNF
18
Show member pathways
8.5CCL20, CXCL10, IL1RAP, IL6, TNF
19
Show member pathways
8.5CCL2, CCL20, CCL3, CCR6, CXCL10
20
Show member pathways
8.5CCL2, CCL20, CCL3, CCR6, CXCL10
218.2CCL2, CCL20, CCL3, IL17A, IL6, TNF
228.2CCL2, CIITA, CXCL10, IL17A, IL17RA, IL2RA
23
Show member pathways
6.8CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
24
Show member pathways
6.8CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
25
Show member pathways
6.5CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
26
Show member pathways
6.3CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A

GO Terms for genes affiliated with Stromal Keratitis

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Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CD69, CXCL10, IL17A, IL2RA, IL6, TNF
2cell surfaceGO:00099868.7AIMP1, CCR6, CIITA, IL2RA, TNF, TNFSF4
3extracellular spaceGO:00056156.5AIMP1, CCL2, CCL20, CCL3, CXCL10, IL17A
4extracellular regionGO:00055766.1CCL2, CCL20, CCL3, CXCL10, IL17A, IL17RA

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:003274710.7IL17A, IL17RA
2fibroblast activationGO:007253710.7IL17A, IL17RA
3positive regulation of cytokine production involved in inflammatory responseGO:190001710.7IL17A, IL17RA
4epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
5negative regulation of lipid storageGO:001088810.6IL6, TNF
6negative regulation of collagen biosynthetic processGO:003296610.5CIITA, IL6
7regulation of vascular endothelial growth factor productionGO:001057410.5CCL2, IL6
8response to auditory stimulusGO:001099610.4CXCL10, IL6
9cellular response to interleukin-6GO:007135410.4CCL2, IL6
10negative regulation of cytokine secretionGO:005071010.4IL6, TNFSF4
11positive regulation of immunoglobulin secretionGO:005102410.4IL6, TNFSF4
12positive regulation of monocyte chemotaxisGO:009002610.3CCL2, CXCL10
13positive regulation of T-helper 2 cell differentiationGO:004563010.3IL6, TNFSF4
14positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.3CCL2, CCL20
15astrocyte cell migrationGO:004361510.2CCL2, CCL3
16macrophage chemotaxisGO:004824610.2CCL2, CCL3
17positive regulation of T cell migrationGO:200040610.2CCL20, CXCL10
18T cell chemotaxisGO:001081810.1CCL3, CXCL10
19positive regulation of calcium ion importGO:009028010.1CCL2, CCL3
20response to amino acidGO:004320010.0CCL2, IL17A, IL6
21response to glucocorticoidGO:005138410.0CCL2, IL6, TNF
22lipopolysaccharide-mediated signaling pathwayGO:003166310.0CCL2, CCL3, TNF
23protein kinase B signalingGO:004349110.0CCL2, CCL3, TNF
24positive regulation of interleukin-6 productionGO:00327559.9IL6, TNF, TNFSF4
25response to antibioticGO:00466779.9CCL2, CIITA, IL6
26response to woundingGO:00096119.9AIMP1, CCL2, IL6, PAX6
27positive regulation of protein kinase B signalingGO:00518979.9CCL3, IL6, TNF
28cellular response to organic cyclic compoundGO:00714079.8CCL2, CCL3, TNF
29humoral immune responseGO:00069599.8CCL2, CCR6, IL6, TNF
30positive regulation of T cell proliferationGO:00421029.8IL2RA, IL6, TNFSF4
31response to virusGO:00096159.8CXCL10, TNF, TNFSF4
32lymphocyte chemotaxisGO:00482479.6CCL2, CCL20, CCL3
33neutrophil chemotaxisGO:00305939.5CCL2, CCL20, CCL3
34MAPK cascadeGO:00001659.3CCL2, CCL3, IL2RA, TNF
35cell surface receptor signaling pathwayGO:00071669.3CCL2, CXCL10, IL17A, IL17RA, IL2RA, TNF
36monocyte chemotaxisGO:00025489.3CCL2, CCL20, CCL3, IL6
37cellular response to interferon-gammaGO:00713469.2CCL2, CCL20, CCL3, CIITA
38positive regulation of gene expressionGO:00106289.2CCL3, IL6, PAX6, TNF
39cell-cell signalingGO:00072679.2AIMP1, CCL20, CCL3, CXCL10, IL17A
40cellular response to tumor necrosis factorGO:00713569.1CCL2, CCL20, CCL3, IL6
41cellular response to interleukin-1GO:00713478.9CCL2, CCL20, CCL3, IL17A, IL6
42cytokine-mediated signaling pathwayGO:00192218.9CCL2, CIITA, IL17RA, IL1RAP, IL6
43chemokine-mediated signaling pathwayGO:00700988.9CCL2, CCL20, CCL3, CCR6, CXCL10
44positive regulation of transcription from RNA polymerase II promoterGO:00459448.8CIITA, CXCL10, IL17A, IL6, PAX6, TNF
45cellular response to lipopolysaccharideGO:00712228.7CCL2, CCL20, CXCL10, IL6, TNF, TNFSF4
46positive regulation of ERK1 and ERK2 cascadeGO:00703748.7CCL2, CCL20, CCL3, IL6, TNF
47chemotaxisGO:00069358.6AIMP1, CCL2, CCL20, CCL3, CCR6, CXCL10
48signal transductionGO:00071657.0AIMP1, CCL2, CCL20, CCR6, CD69, CXCL10
49inflammatory responseGO:00069546.8AIMP1, CCL2, CCL20, CCL3, CIITA, CXCL10
50immune responseGO:00069556.7CCL2, CCL20, CCL3, CCR6, CIITA, CXCL10

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080098.8CCL2, CCL20, CCL3, CXCL10
2cytokine activityGO:00051258.7AIMP1, CCL20, IL17A, IL6, TNF, TNFSF4

Sources for Stromal Keratitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet