MCID: STR072
MIFTS: 31

Stromal Keratitis malady

Eye diseases category

Summaries for Stromal Keratitis

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32MalaCards
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MalaCards: Stromal Keratitis is related to keratitis and uveitis. An important gene associated with Stromal Keratitis is TNFSF4 (tumor necrosis factor (ligand) superfamily, member 4), and among its related pathways are TSLP Signaling Pathway and Th17 Differentiation. The compounds mip-3alpha and larc have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Stromal Keratitis

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Sources:
48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
stromal keratitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

stromal keratitis 48 60


External Ids:

SNOMED-CT via Orphanet57 1763009
UMLS via Orphanet61 C1318020

Related Diseases for Stromal Keratitis

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17GeneCards, 18GeneDecks
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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis31.7IL17A
2uveitis30.2CD69, IL2RA, IL17A
3herpes simplex10.8
4eye disease10.4
5corneal neovascularization10.3
6iritis10.2
7lyme disease10.0
8herpes zoster10.0
9b cell deficiency10.0
10corneal edema10.0
11deep keratitis10.0
12dysgammaglobulinemia10.0
13interstitial keratitis10.0
14iridocyclitis10.0
15scleritis10.0
16superficial keratitis10.0
17systemic lupus erythematosus10.0TNFSF4
18peritonitis10.0CD69
19arthropathy10.0CD69
20dermatitis10.0IL17A
21allergic rhinitis10.0IL17A
22nephritis10.0IL17A
23vitiligo10.0CIITA
24gingivitis10.0IL17A
25stomach cancer10.0CIITA
26pneumonia10.0IL17A
27neuritis10.0CIITA
28wegener's granulomatosis10.0CIITA
29myocarditis10.0CIITA
30obesity10.0IL17A
31colorectal cancer10.0AIMP1, CCR6
32thyroiditis10.0CIITA
33sarcoma10.0AIMP1
34common variable immune deficiency10.0IL2RA
35hepatitis c10.0CIITA, CCL20
36dermatitis herpetiformis10.0TRB
37celiac disease10.0TRB, CIITA
38kawasaki disease10.0TRB, CIITA
39atherosclerosis10.0IL17A, CIITA
40proteinuria10.0TRB, LCN1
41vasculitis10.0TNFSF4, TRB, IL17A
42eosinophilia10.0CD69, IL2RA
43hepatocellular carcinoma10.0CIITA, CCL20, CCR6
44cystic fibrosis10.0CCL20, TRB, IL17A
45connective tissue disease10.0IL2RA, CD69
46lupus nephritis10.0IL2RA, CIITA
47adult t-cell leukemia10.0IL2RA, TRB
48lymphopenia10.0IL2RA, CIITA
49osteoarthritis10.0IL17A, IL1RAP, CCL20
50mycosis fungoides10.0TRB, IL2RA

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Clinical Features for Stromal Keratitis

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Drugs & Therapeutics for Stromal Keratitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Stromal Keratitis

Drug clinical trials:

Search ClinicalTrials for Stromal Keratitis

Search NIH Clinical Center for Stromal Keratitis

Search CenterWatch for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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32MalaCards
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MalaCards organs/tissues related to Stromal Keratitis:

32
Eye

Animal Models for Stromal Keratitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Stromal Keratitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.3TNFSF4, CIITA, TRB, CD69, IL2RA, IL17RA
2MP:00053977.0CCR6, TNFSF4, CIITA, TRB, CD69, IL2RA
3MP:00053876.1IL17A, CCR6, TNFSF4, CIITA, AIMP1, TRB

Publications for Stromal Keratitis

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Genetic Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Stromal Keratitis

Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Stromal Keratitis

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Stromal Keratitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1mip-3alpha4410.0CCR6, CCL20
2larc449.9CCL20, CCR6
3tuberculin449.7CD69, IL2RA
4ecori449.7TRB, CIITA
5enterotoxin449.6TRB, CIITA
6ccl444 2810.6IL17A, CCL20, CCR6
7endotoxin449.5IL17A, CIITA, CCL20
8mannose449.4CIITA, CD69, IL17A
9phorbol 12,13-dibutyrate449.3IL2RA, CD69
10ionomycin449.3IL17A, IL2RA, CD69
11allergens449.3CCL20, CIITA, CD69
12tacrolimus44 49 1111.3CD69, IL2RA, IL17A
13phorbol449.2IL2RA, CD69, TRB
14methotrexate44 49 1111.2CD69, IL2RA, IL17A
15con a449.1CD69, IL2RA
16dexamethasone44 49 28 1112.1CCL20, CIITA, IL1RAP
17thymidine44 2410.0IL17A, IL2RA, CD69, CIITA
18creatinine448.9LCN1, CD69, IL2RA, IL17A
19oligonucleotide448.7IL17A, TRB, CIITA, CCL20
20rantes448.6IL17A, IL17RA, IL2RA, CIITA, CCL20, CCR6
21cyclosporin a44 28 5910.5CIITA, TRB, CD69, IL2RA, IL17A
22lipid448.4LCN1, CCR6, CIITA, CD69, IL17A
23nitric oxide44 11 2410.1CCL20, CIITA, CD69, IL1RAP, IL17A
24tyrosine447.7CIITA, TRB, CD69, IL2RA, IL1RAP, IL17A

GO Terms for genes affiliated with Stromal Keratitis

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Sources:
16Gene Ontology
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Cellular components related to Stromal Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IL17A, IL2RA, CD69
2integral to plasma membraneGO:0058877.9IL17RA, IL1RAP, CD69, TNFSF4, CCR6

Biological processes related to Stromal Keratitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:07253710.0IL17RA, IL17A
2positive regulation of interleukin-23 productionGO:03274710.0IL17A, IL17RA
3positive regulation of cytokine production involved in inflammatory responseGO:19000179.9IL17A, IL17RA
4positive regulation of activated T cell proliferationGO:0421049.5TNFSF4, IL2RA
5cell-cell signalingGO:0072679.3IL17A, AIMP1, CCL20
6chemotaxisGO:0069359.2AIMP1, CCL20, CCR6
7inflammatory responseGO:0069548.5CCL20, AIMP1, IL1RAP, IL17A
8immune responseGO:0069557.9IL17A, IL1RAP, IL2RA, CIITA, CCL20, CCR6

Molecular functions related to Stromal Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.6IL17A, AIMP1, TNFSF4

Products for genes affiliated with Stromal Keratitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Stromal Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet