MCID: STR072
MIFTS: 46

Stromal Keratitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Stromal Keratitis

About this section
Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Stromal Keratitis:

Name: Stromal Keratitis 54 68

Characteristics:

Orphanet epidemiological data:

54
stromal keratitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Orphanet54 ORPHA137599
UMLS via Orphanet69 C1318020
ICD10 via Orphanet31 H16.3

Summaries for Stromal Keratitis

About this section
MalaCards based summary: Stromal Keratitis is related to keratitis and herpes simplex, and has symptoms including Array, Array and Array. An important gene associated with Stromal Keratitis is TNF (Tumor Necrosis Factor), and among its related pathways are IL27-mediated signaling events and Development and heterogeneity of the ILC family. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Stromal Keratitis

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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.5
2herpes simplex10.4
3vps11-related autosomal recessive hypomyelinating leukodystrophy10.3IL6, TNF
4trichomalacia10.3IL17A, IL6, TNF
5gastric dilatation10.3IL17A, IL6, TNF
6crohn's colitis10.3IL17A, IL6, TNF
7keratoconus10.3IL17A, IL6, TNF
8orbital osteomyelitis10.3IL17A, IL6, TNF
9disease of mental health10.3IL17A, IL6, TNF
10motor peripheral neuropathy10.3IL17A, IL17RA, TNF
11follicular adenoma10.3IL17A, IL6, TNF
12aortic coarctation10.2IL2RA, IL6, TNF
13cyclosporiasis10.2IL2RA, IL6, TNF
14erb-duchenne and dejerine-klumpke palsies10.2IL2RA, IL6, TNF
15vogt-koyanagi-harada disease10.2CXCL10, IL6, TNF
16burns10.2IL17A, IL6, TNF
17uterine adnexa cancer10.2IL17A, IL6, TNF
18immunoglobulin g deficiency10.2IL2RA, IL6, TNF
19myiasis10.2IL2RA, IL6, TNF
20parasitic protozoa infectious disease10.2IL17A, IL6, TNF
21glucose intolerance10.2CCL2, IL2RA, TNF
22motility-related diarrhea10.2CCL2, IL6, TNF
23central nervous system lymphoma10.2CCL2, IL6, TNF
24atrophy of prostate10.2CCL2, IL6, TNF
25periodontosis10.2CXCL10, IL2RA, TNF
26oppositional defiant disorder10.2CCL2, IL6, TNF
27choroiditis10.2CCL2, IL6, TNF
28infancy electroclinical syndrome10.2CCL2, IL6, TNF
29blue toe syndrome10.2CIITA, IL6, TNF
30hyperimmunoglobulin syndrome10.2CCL2, CXCL10, TNF
31mixed mineral dust pneumoconiosis10.2CCL2, CXCL10, IL6
32status epilepticus10.2CCL2, CXCL10, TNF
33foodborne botulism10.2CXCL10, IL17A, IL6, TNF
34retinal ischemia10.2CCL2, IL2RA, TNF
35baritosis10.2CCL2, IL6, TNF
36stocco dos santos syndrome10.2CIITA, TNF
37amelogenesis imperfecta10.2CCL2, IL6, TNF
38uterine ligament clear cell adenocarcinoma10.2IL17A, IL6, TNF
39breast apocrine carcinoma in situ10.1CCL2, IL2RA, IL6
40tuberculosis10.1CCL2, IL17A, IL6, TNF
41neonatal jaundice10.1CCL2, IL17A, IL6, TNF
42bone angioendothelial sarcoma10.1CCL2, IL17A, IL6, TNF
43acute chest syndrome10.1CCL2, IL17A, IL6, TNF
44neovascular glaucoma10.1CCL2, IL6, TNF
45intratubular embryonal carcinoma10.1CCL2, IL17A, IL6, TNF
46substance-induced psychosis10.1CCL2, IL17A, IL6, TNF
47ulcerative proctitis10.1CCL2, CCL3, TNF
48smooth muscle tumor10.1CCL2, IL17A, IL2RA, IL6
49bladder signet ring cell adenocarcinoma10.1CCL2, CXCL10, IL6, TNF
50vulvar nodular hidradenoma10.1IL17A, IL17RA, IL2RA, IL6, TNF

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms & Phenotypes for Stromal Keratitis

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Human phenotypes related to Stromal Keratitis:

 54 64 (show all 11)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 reduced visual acuity64 54 Very frequent (99-80%) HP:0007663
2 deep anterior chamber64 54 Very frequent (99-80%) HP:0007765
3 corneal stromal edema64 54 Very frequent (99-80%) HP:0012040
4 primary open angle glaucoma64 54 Very frequent (99-80%) HP:0012108
5 herpetiform corneal ulceration64 54 Frequent (79-30%) HP:0007812
6 increased lacrimation64 54 Frequent (79-30%) HP:0009926
7 descemet membrane folds64 54 Frequent (79-30%) HP:0012039
8 decreased corneal sensation64 54 Frequent (79-30%) HP:0012155
9 corneal perforation64 54 Frequent (79-30%) HP:0100583
10 keratitis64 54 Occasional (29-5%) HP:0000491
11 blindness64 54 Occasional (29-5%) HP:0000618

MGI Mouse Phenotypes related to Stromal Keratitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4CCR6, CD69, CIITA, CXCL10, IL17A, IL17RA
2MP:00053876.2AIMP1, CCL2, CCR6, CD69, CIITA, CXCL10

Drugs & Therapeutics for Stromal Keratitis

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Drugs for Stromal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Antiviral AgentsPhase 4, Phase 39967
2Anti-Infective AgentsPhase 4, Phase 322062
3AcyclovirPhase 4, Phase 3183
4valacyclovirPhase 4106
5
Methylprednisoloneapproved, vet_approvedPhase 3119383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
6
Prednisoloneapproved, vet_approvedPhase 3119350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
7Peripheral Nervous System AgentsPhase 323689
8Prednisolone phosphatePhase 31193
9Protective AgentsPhase 37443
10Neuroprotective AgentsPhase 31716
11Prednisolone hemisuccinatePhase 31193
12Prednisolone acetatePhase 31193
13Autonomic AgentsPhase 310150
14AntiemeticsPhase 34022
15Methylprednisolone HemisuccinatePhase 31193
16Gastrointestinal AgentsPhase 38402
17HormonesPhase 314415
18Methylprednisolone acetatePhase 31193
19
Riboflavinapproved, nutraceutical, vet_approved17483-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
20
Folic Acidapproved, nutraceutical, vet_approved439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
21Vitamin B Complex4337
22Vitamins5282
23Dermatologic Agents5806
24Trace Elements6001
25Micronutrients6001
26Photosensitizing Agents492
27Vitamin B9Nutraceutical4392
28Vitamin B2Nutraceutical174
29FolateNutraceutical4392

Interventional clinical trials:

idNameStatusNCT IDPhase
1Zoster Eye Disease StudyNot yet recruitingNCT03134196Phase 4
2Herpetic Eye Disease Study (HEDS) IUnknown statusNCT00000138Phase 3
3Herpetic Eye Disease Study (HEDS) IICompletedNCT00000139Phase 3
4Cross Linking for Treatment of Corneal InfectionTerminatedNCT00912509

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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MalaCards organs/tissues related to Stromal Keratitis:

36
Eye, T cells, Endothelial, Neutrophil, B cells, Lymph node, Skin

Publications for Stromal Keratitis

About this section

Articles related to Stromal Keratitis:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation. (28513490)
2017
2
Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis. (27798158)
2016
3
Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. (27684823)
2016
4
Microsporidial stromal keratitis and endophthalmitis in an immunocompetent patient. (27528053)
2016
5
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. (27849421)
2016
6
A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. (27070108)
2016
7
Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis. (27275421)
2016
8
Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis. (26758184)
2016
9
Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty. (26989540)
2016
10
Microsporidial Stromal Keratitis: Clinical Features, Unique Diagnostic Criteria, and Treatment Outcomes in a Large Case Series. (27467044)
2016
11
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. (27977029)
2016
12
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). (27257731)
2016
13
Amniotic membrane transplantation in bacterial and herpetic stromal keratitis. (27511511)
2016
14
Stromal keratitis in a neonate: Herpes virus a diagnosis to consider. (26710660)
2016
15
Intrastromal bevacizumab injection for corneal neovascularization in herpetic stromal keratitis. (26342658)
2015
16
Prevention of herpes simplex virus induced stromal keratitis by a glycoprotein B-specific monoclonal antibody. (25587898)
2015
17
Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice. (26504854)
2015
18
Role of miR-155 in the Pathogenesis of Herpetic Stromal Keratitis. (25700796)
2015
19
Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology. (26507231)
2015
20
Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study. (26590045)
2015
21
Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. (25996419)
2015
22
IL-2/anti-IL-2 antibody complex treatment inhibits the development but not the progression of herpetic stromal keratitis. (25411200)
2015
23
Microsporidial stromal keratitis masquerading as acute graft rejection. (25533000)
2015
24
Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis. (25785282)
2015
25
Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis. (26555580)
2015
26
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia. (25826328)
2015
27
Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. (26444718)
2015
28
Idiopathic stromal keratitis resembling central toxic keratopathy. (26210054)
2015
29
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. (25859798)
2015
30
Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis. (26720197)
2015
31
Do Unilateral Herpetic Stromal Keratitis and Neurotrophic Ulcers Cause Bilateral Dry Eye? (25933398)
2015
32
Corneal lymphangiogenesis in herpetic stromal keratitis. (25444520)
2015
33
Herpes zoster stromal keratitis after varicella vaccine booster in a pediatric patient. (25062334)
2014
34
Correlation between matrix metalloproteinase expression and activation of the focal adhesion kinase signaling pathway in herpes stromal keratitis. (24348806)
2014
35
Reversible nerve damage and corneal pathology in murine herpes simplex stromal keratitis. (24789786)
2014
36
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. (24651695)
2014
37
Varicella-zoster virus detection in varicella-associated stromal keratitis. (24723158)
2014
38
CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. (24442436)
2014
39
A young immunocompetent patient with bilateral immune stromal keratitis due to varicella zoster and herpes simplex. (24985896)
2014
40
Pressure-induced stromal keratitis. (23479805)
2013
41
Potential function of miRNAs in herpetic stromal keratitis. (23329734)
2013
42
Controlling herpetic stromal keratitis by modulating lymphotoxin-alpha-mediated inflammatory pathways. (23850656)
2013
43
Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice. (23720717)
2013
44
Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization. (22892644)
2013
45
Pressure-induced interlamellar stromal keratitis after vitreoretinal surgery. (25390813)
2013
46
Unilateral posterior stromal keratitis possibly secondary to Lyme disease. (23132459)
2013
47
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
48
Mice with mutations in Fas and Fas ligand demonstrate increased herpetic stromal keratitis following corneal infection with HSV-1. (22156346)
2012
49
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
50
Recurrent herpetic stromal keratitis in mice: a model for studying human HSK. (22593769)
2012

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8IL17A, IL6, TNF
29.8IL17A, IL6, TNF
39.8IL17RA, IL6, TNF
4
Show member pathways
9.8IL17A, IL17RA, IL6
59.8IL2RA, IL6, TNF
69.7CCL2, IL6, TNF
79.7CCL2, IL6, TNF
89.6IL6, TNF, TRB
99.5CCL2, IL17A, IL6, TNF
109.4IL1RAP, TNF, TRB
11
Show member pathways
9.4IL17A, IL6, TNF, TRB
129.4CCR6, IL2RA, IL6, TNF
139.4CCL2, CXCL10, IL6, TNF
14
Show member pathways
9.4CCL3, IL2RA, TNF
15
Show member pathways
9.3IL17A, IL17RA, IL1RAP, IL6
169.3CCL2, CCL3, TNF
17
Show member pathways
9.2CIITA, IL17A, IL2RA, IL6, TNF
189.2CD69, IL2RA, IL6, TNF
199.1CCL2, CCL3, IL6, TNF
208.9CCL3, CCR6, IL17A, IL2RA, TNF
21
Show member pathways
8.8CCL2, CIITA, CXCL10, IL2RA, IL6, TNF
22
Show member pathways
8.8CCL2, CCL3, CXCL10, IL6, TNF
23
Show member pathways
8.7IL17A, IL1RAP, IL2RA, IL6, TNF, TRB
248.6CCL2, CIITA, CXCL10, IL17A, IL2RA, TNF
258.6CCL2, CCL20, CXCL10, IL6, TNF
26
Show member pathways
8.5CCL20, CXCL10, IL1RAP, IL6, TNF
27
Show member pathways
8.1CCL2, CCL20, CXCL10, IL17A, IL17RA, IL6
28
Show member pathways
8.1CCL2, CCL20, CCL3, CCR6, CXCL10
29
Show member pathways
8.1CCL2, CCL20, CCL3, CCR6, CXCL10
308.0CCL2, CCL20, CCL3, IL17A, IL6, TNF
317.9CCL2, CCL20, CCL3, CXCL10, IL6, TNF
327.5CCL2, CCL20, CCL3, CXCL10, IL17A, IL6
33
Show member pathways
6.7CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
34
Show member pathways
6.7CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
35
Show member pathways
6.3CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
36
Show member pathways
6.3CCL2, CCL20, CCL3, CIITA, CXCL10, IL17A
37
Show member pathways
6.2CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
38
Show member pathways
5.9CCL2, CCL20, CCL3, CCR6, CIITA, CXCL10

GO Terms for genes affiliated with Stromal Keratitis

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Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.7AIMP1, CCR6, CIITA, IL2RA, TNF, TNFSF4
2external side of plasma membraneGO:00098979.5CD69, CXCL10, IL17A, IL2RA, IL6, TNF
3extracellular regionGO:00055767.0AIMP1, CCL2, CCL20, CCL3, CXCL10, IL17A
4extracellular spaceGO:00056156.3AIMP1, CCL2, CCL20, CCL3, CXCL10, IL17A

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:007253710.8IL17A, IL17RA
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.8IL6, TNF
3positive regulation of cytokine production involved in inflammatory responseGO:190001710.8IL17A, IL17RA
4acute inflammatory responseGO:000252610.8IL6, TNFSF4
5positive regulation of interleukin-23 productionGO:003274710.8IL17A, IL17RA
6negative regulation of lipid storageGO:001088810.8IL6, TNF
7positive regulation of chemokine productionGO:003272210.8IL6, TNF
8negative regulation of cytokine secretionGO:005071010.8IL6, TNFSF4
9positive regulation of immunoglobulin secretionGO:005102410.8IL6, TNFSF4
10positive regulation of T-helper 2 cell differentiationGO:004563010.8IL6, TNFSF4
11negative regulation of collagen biosynthetic processGO:003296610.7CIITA, IL6
12response to auditory stimulusGO:001099610.7CXCL10, IL6
13regulation of vascular endothelial growth factor productionGO:001057410.6CCL2, IL6
14leukocyte migration involved in inflammatory responseGO:000252310.6CCL2, CCR6
15positive regulation of interleukin-13 productionGO:003273610.6IL1RAP, TNFSF4
16positive regulation of interleukin-6 productionGO:003275510.6IL6, TNF, TNFSF4
17positive regulation of T cell proliferationGO:004210210.5IL2RA, IL6, TNFSF4
18response to glucocorticoidGO:005138410.4CCL2, IL6, TNF
19granulocyte chemotaxisGO:007162110.4CCL3, IL17RA
20response to antibioticGO:004667710.3CCL2, CIITA, IL6
21astrocyte cell migrationGO:004361510.3CCL2, CCL3
22macrophage chemotaxisGO:004824610.3CCL2, CCL3
23positive regulation of calcium ion importGO:009028010.3CCL2, CCL3
24positive regulation of inflammatory responseGO:005072910.2CCL3, IL17RA, TNFSF4
25positive regulation of protein kinase B signalingGO:005189710.2CCL3, IL6, TNF
26cell surface receptor signaling pathwayGO:000716610.2CCL2, CXCL10, IL17RA, IL2RA
27humoral immune responseGO:000695910.1CCL2, CCR6, IL6, TNF
28positive regulation of T cell migrationGO:200040610.1CCL20, CXCL10
29cellular response to organic cyclic compoundGO:007140710.1CCL2, CCL3, TNF
30lipopolysaccharide-mediated signaling pathwayGO:003166310.1CCL2, CCL3, TNF
31positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.1CCL2, CCL20
32protein kinase B signalingGO:004349110.1CCL2, CCL3, TNF
33cytokine-mediated signaling pathwayGO:001922110.0CCL2, IL17RA, IL1RAP, IL6
34response to woundingGO:000961110.0AIMP1, CCL2, IL6, PAX6
35MAPK cascadeGO:00001659.8CCL2, CCL3, IL2RA, TNF
36T cell chemotaxisGO:00108189.8CCL3, CXCL10
37positive regulation of transcription from RNA polymerase II promoterGO:00459449.6CIITA, CXCL10, IL17A, IL6, PAX6, TNF
38lymphocyte chemotaxisGO:00482479.5CCL2, CCL20, CCL3
39neutrophil chemotaxisGO:00305939.5CCL2, CCL20, CCL3
40thymocyte migrationGO:00726799.3CCL20, CCR6
41T cell migrationGO:00726789.2CCL20, CCR6
42cellular response to tumor necrosis factorGO:00713569.2CCL2, CCL20, CCL3, IL6
43monocyte chemotaxisGO:00025489.2CCL2, CCL20, CCL3, IL6
44cellular response to interferon-gammaGO:00713469.2CCL2, CCL20, CCL3, CIITA
45cellular response to lipopolysaccharideGO:00712229.1CCL2, CCL20, CXCL10, IL6, TNF, TNFSF4
46cell-cell signalingGO:00072679.1AIMP1, CCL20, CCL3, CXCL10, IL17A
47cellular response to interleukin-1GO:00713479.0CCL2, CCL20, CCL3, IL17A, IL6
48positive regulation of ERK1 and ERK2 cascadeGO:00703749.0CCL2, CCL20, CCL3, IL6, TNF
49cell chemotaxisGO:00603268.9CCL2, CCL20, CCL3, CCR6, CXCL10
50chemokine-mediated signaling pathwayGO:00700988.9CCL2, CCL20, CCL3, CCR6, CXCL10

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.1CCL2, CXCL10, IL17RA, IL6, TNFSF4
2chemokine activityGO:00080099.1CCL2, CCL20, CCL3, CXCL10
3cytokine activityGO:00051257.9AIMP1, CCL2, CCL20, CCL3, CXCL10, IL17A

Sources for Stromal Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet