MCID: STR072
MIFTS: 41

Stromal Keratitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Stromal Keratitis

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Sources:
52Orphanet, 66UMLS, 29ICD10 via Orphanet, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Stromal Keratitis:

Name: Stromal Keratitis 52 66

Characteristics:

Orphanet epidemiological data:

52
stromal keratitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 52 
Rare eye diseases


External Ids:

Orphanet52 ORPHA137599
ICD10 via Orphanet29 H16.3
UMLS via Orphanet67 C1318020

Summaries for Stromal Keratitis

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MalaCards based summary: Stromal Keratitis is related to keratitis and herpes simplex. An important gene associated with Stromal Keratitis is PAX6 (Paired Box 6), and among its related pathways are TSLP Signaling Pathway and IL27-mediated signaling events. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Stromal Keratitis

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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.3
2herpes simplex10.6
3crohn's colitis10.5IL2RA, TNF
4baetz-greenwalt syndrome10.5CIITA, TNF
5chronic conjunctivitis10.5IL17A, IL17RA, TNF
6graft-versus-host disease, protection against10.5IL2RA, TNF
7stone in bladder diverticulum10.4PAX6, TNF
8loin pain hematuria syndrome10.4CCL20, CCR6, TNF
9panner disease10.3IL6, TNF
10polyradiculoneuropathy10.3IL17A, IL2RA, IL6
11night blindness10.3IL17A, TNF
12toxic maculopathy10.3CXCL10, IL2RA, TNF
13aortic arch interruption10.3IL6, TNF
14uterine corpus dissecting leiomyoma10.3CCL3, IL17A, TNF
15tricho odonto onycho dermal syndrome10.2IL17A, IL6, TNF
16gastroduodenal crohn's disease10.2IL17A, IL6, TNF
17keloids10.2IL17A, IL6, TNF
18orbital periostitis10.2IL17A, IL6, TNF
19corneal intraepithelial neoplasm10.2IL17A, IL6, TNF
20cutaneous leishmaniasis10.2IL6, TNF
21reproductive system disease10.2IL17A, IL6, TNF
22maligant granulosa cell tumor of ovary10.2IL6, TNF
23retroperitoneal fibrosis10.2IL2RA, IL6, TNF
24burn scar10.2IL17A, IL6, TNF
25parametrium malignant neoplasm10.2IL17A, IL6, TNF
26esophagus melanoma10.2IL2RA, IL6, TNF
27lung sarcoma10.2IL17A, IL6, TNF
28blood group incompatibility10.2IL17A, IL6, TNF
29rectum leiomyosarcoma10.1IL17A, IL6, TNF
30hemometra10.1IL6, TNF
31autoimmune myocarditis10.1IL17A, IL2RA
32perianal skin paget's disease10.1IL17A, IL6, TNF
33eye disease10.1
34thoracic aortic aneurysm10.0IL6, LCN1, TNF
35corneal neovascularization10.0
36endotheliitis10.0
37thymus lymphoma10.0IL6, LCN1, TNF
38benign adult familial myoclonic epilepsy10.0IL2RA, IL6
39uveitis10.0
40scrotum paget's disease10.0IL6, TNF
41renal tubular acidosis10.0CCL2, IL2RA, TNF
42atypical depressive disorder9.9CXCL10, IL6, TNF
43chronic intestinal vascular insufficiency9.9IL6, PAX6, TNF
44heart leiomyosarcoma9.9CCL3, IL6, TNF
45keratopathy9.9
46iritis9.9
47herpes zoster9.9
48opportunistic bacterial infectious disease9.9CXCL10, IL6, TNF
49taylor's syndrome9.8CXCL10, IL6, TNF
50progressive relapsing multiple sclerosis9.8CCL2, CXCL10, IL17A

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms for Stromal Keratitis

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Drugs & Therapeutics for Stromal Keratitis

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Drugs for Stromal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AcyclovirPhase 3176
2
PrednisolonePhase 3111850-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3PREDNISOLONE ACETATEPhase 31118
4
MethylprednisolonePhase 3111883-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
5
RiboflavinNutraceutical15883-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
6FolateNutraceutical4143
7
Folic AcidNutraceutical414359-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10

Interventional clinical trials:

idNameStatusNCT IDPhase
1Herpetic Eye Disease Study (HEDS) IICompletedNCT00000139Phase 3
2Herpetic Eye Disease Study (HEDS) IActive, not recruitingNCT00000138Phase 3
3Cross Linking for Treatment of Corneal InfectionTerminatedNCT00912509

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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MalaCards organs/tissues related to Stromal Keratitis:

34
Eye, T cells, Endothelial, Neutrophil, B cells, Lymph node, Skin

Animal Models for Stromal Keratitis or affiliated genes

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MGI Mouse Phenotypes related to Stromal Keratitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.2CCR6, CD69, CIITA, CXCL10, IL17A, IL17RA
2MP:00053875.8AIMP1, CCL2, CCR6, CD69, CIITA, CXCL10

Publications for Stromal Keratitis

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Articles related to Stromal Keratitis:

(show top 50)    (show all 217)
idTitleAuthorsYear
1
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). (27257731)
2016
2
Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study. (26590045)
2015
3
Idiopathic stromal keratitis resembling central toxic keratopathy. (26210054)
2015
4
Microsporidial stromal keratitis masquerading as acute graft rejection. (25533000)
2015
5
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. (25859798)
2015
6
Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis. (26720197)
2015
7
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. (24651695)
2014
8
Correlation between matrix metalloproteinase expression and activation of the focal adhesion kinase signaling pathway in herpes stromal keratitis. (24348806)
2014
9
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
10
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
11
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
12
Elevated intraocular pressure-induced interlamellar stromal keratitis occurring 9 years after laser in situ keratomileusis. (21941173)
2012
13
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
14
Management of herpes simplex virus stromal keratitis: an evidence-based review. (19298901)
2009
15
Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis. (18689698)
2008
16
Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. (18580272)
2008
17
Interferon gamma is not required for recurrent herpetic stromal keratitis. (18755490)
2008
18
Topical antisense-oligonucleotides targeting IFN-gamma mRNA improve incidence and severity of herpetic stromal keratitis by cytokine specific and sequence unspecific effects. (18030487)
2008
19
Activated inflammatory infiltrate in HSV-1-infected corneas without herpes stromal keratitis. (18385067)
2008
20
Granulocyte macrophage colony-stimulating factor expression in human herpetic stromal keratitis: implications for the role of neutrophils in HSK. (17197544)
2007
21
Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects. (16951377)
2006
22
Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines. (16178874)
2005
23
Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (16249483)
2005
24
Chronic microsporidial stromal keratitis in an immunocompetent, non-contact lens wearer. (15976469)
2005
25
Is microsporidial keratitis an emerging cause of stromal keratitis? A case series study. (16105181)
2005
26
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
27
Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis. (15585885)
2004
28
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. (12421973)
2002
29
Spontaneous reduction in myopic correction following varicella disciform stromal keratitis. (12140227)
2002
30
Topical administration of HSV gD-IL-2 DNA is highly protective against murine herpetic stromal keratitis. (11805518)
2002
31
Herpetic stromal keratitis in the absence of viral antigen recognition. (12576029)
2002
32
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
33
Stromal keratitis and anterior uveitis due to herpes simplex virus-2 in a young child. (11754904)
2001
34
Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (10922194)
2000
35
Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells. (10937573)
2000
36
Control of herpetic stromal keratitis using CTLA4Ig fusion protein. (9434800)
1998
37
Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis. (9557652)
1998
38
Topical cyclosporin as an adjunct to topical acyclovir treatment in herpetic stromal keratitis. (9380342)
1997
39
Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group. (8976723)
1996
40
Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. (7561104)
1995
41
Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. (8051423)
1994
42
Passive transfer of anti-herpes simplex virus type 2 monoclonal and polyclonal antibodies protect against herpes simplex virus type 1-induced but not herpes simplex virus type 2-induced stromal keratitis. (8392037)
1993
43
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
44
Obstinate cases of stromal keratitis treated by combined traditional Chinese and Western medicine. (1453751)
1992
45
Effects of 9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) eye drops and cyclosporine eye drops in the treatment of herpetic stromal keratitis in rabbits. (1650668)
1991
46
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
47
Quantitation of purified monoclonal antibody needed to prevent HSV-1 induced stromal keratitis in mice. (2736955)
1989
48
Corneal endothelial changes associated with herpetic stromal keratitis. (3411807)
1988
49
Clinical, pathologic, and immunopathologic characteristics of experimental murine herpes simplex virus stromal keratitis and uveitis is controlled by gene products from the Igh-1 locus on chromosome 12. (3128902)
1987
50
Corticosteroid therapy in central stromal keratitis. (4182154)
1969

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL2RA, IL6, TNFSF4
2
Show member pathways
9.6IL17A, IL6, TNF
39.6IL2RA, IL6, TNF
4
Show member pathways
9.6IL17A, IL17RA, IL6
59.6IL17RA, IL6, TNF
69.5IL6, TNF, TRB
7
Show member pathways
9.5CCL3, IL2RA, TNF
89.4IL1RAP, TNF, TRB
99.4CCL2, IL6, TNF
10
Show member pathways
9.4CCL2, IL6, TNF
119.4CCL2, IL6, TNF
129.4CCR6, IL2RA, IL6, TNF
139.3CCL2, CCL3, TNF
14
Show member pathways
9.2CCL2, IL17A, IL6, TNF
15
Show member pathways
9.2IL17A, IL17RA, IL1RAP, IL6
169.1CCL2, CXCL10, IL6, TNF
179.0CCL3, CCR6, IL17A, IL2RA, TNF
188.8CD69, IL2RA, IL6, TNF
198.7CCL2, CIITA, CXCL10, IL2RA, TNF, TNFSF4
20
Show member pathways
8.6CCL2, CIITA, CXCL10, IL2RA, IL6, TNF
218.6CCL2, CCL20, CXCL10, IL6, TNF
22
Show member pathways
8.6CCL2, CCL3, CXCL10, IL6, TNF
23
Show member pathways
8.5CCL20, CXCL10, IL1RAP, IL6, TNF
24
Show member pathways
8.4CCL2, CCL20, CCL3, CCR6, CXCL10
25
Show member pathways
8.4CCL2, CCL20, CCL3, CCR6, CXCL10
26
Show member pathways
8.2CCL2, CCL20, CCL3, IL17A, IL2RA, IL6
278.2CCL2, CCL20, CCL3, IL17A, IL6, TNF
28
Show member pathways
8.0CCL2, CCL20, CCL3, IL17A, IL2RA, IL6
297.6CCL2, CCL20, CCL3, CXCL10, IL17A, IL6
30
Show member pathways
6.8CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
31
Show member pathways
6.8CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
32
Show member pathways
6.6CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
33
Show member pathways
6.4CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A

GO Terms for genes affiliated with Stromal Keratitis

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Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.9AIMP1, CCR6, CIITA, IL2RA, TNF, TNFSF4
2external side of plasma membraneGO:00098978.6CD69, CXCL10, IL17A, IL2RA, IL6, TNF
3extracellular spaceGO:00056156.7AIMP1, CCL2, CCL20, CCL3, CXCL10, IL17A
4extracellular regionGO:00055766.2CCL2, CCL20, CCL3, CXCL10, IL17A, IL17RA

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:007253710.7IL17A, IL17RA
2positive regulation of cytokine production involved in inflammatory responseGO:190001710.6IL17A, IL17RA
3positive regulation of immunoglobulin secretionGO:005102410.6IL6, TNFSF4
4epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
5positive regulation of interleukin-23 productionGO:003274710.5IL17A, IL17RA
6positive regulation of T-helper 2 cell differentiationGO:004563010.5IL6, TNFSF4
7positive regulation of interleukin-13 productionGO:003273610.5IL1RAP, TNFSF4
8negative regulation of cytokine secretionGO:005071010.5IL6, TNFSF4
9negative regulation of lipid storageGO:001088810.4IL6, TNF
10leukocyte migration involved in inflammatory responseGO:000252310.4CCL2, CCR6
11negative regulation of collagen biosynthetic processGO:003296610.4CIITA, IL6
12regulation of vascular endothelial growth factor productionGO:001057410.4CCL2, IL6
13granulocyte chemotaxisGO:007162110.4CCL3, IL17RA
14response to auditory stimulusGO:001099610.4CXCL10, IL6
15T cell migrationGO:007267810.3CCL20, CCR6
16thymocyte migrationGO:007267910.3CCL20, CCR6
17positive regulation of monocyte chemotaxisGO:009002610.3CCL2, CXCL10
18astrocyte cell migrationGO:004361510.2CCL2, CCL3
19positive regulation of T cell migrationGO:200040610.2CCL20, CXCL10
20macrophage chemotaxisGO:004824610.1CCL2, CCL3
21T cell chemotaxisGO:001081810.1CCL3, CXCL10
22response to glucocorticoidGO:005138410.0CCL2, IL6, TNF
23positive regulation of interleukin-6 productionGO:003275510.0IL6, TNF, TNFSF4
24lipopolysaccharide-mediated signaling pathwayGO:00316639.9CCL2, CCL3, TNF
25protein kinase B signalingGO:00434919.9CCL2, CCL3, TNF
26positive regulation of T cell proliferationGO:00421029.9IL2RA, IL6, TNFSF4
27response to antibioticGO:00466779.9CCL2, CIITA, IL6
28humoral immune responseGO:00069599.8CCL2, CCR6, IL6, TNF
29positive regulation of protein kinase B signalingGO:00518979.8CCL3, IL6, TNF
30response to woundingGO:00096119.8AIMP1, CCL2, IL6, PAX6
31cellular response to organic cyclic compoundGO:00714079.7CCL2, CCL3, TNF
32response to amino acidGO:00432009.7CCL2, IL17A, IL6
33positive regulation of inflammatory responseGO:00507299.6CCL2, CCL3, IL17RA, TNFSF4
34lymphocyte chemotaxisGO:00482479.6CCL2, CCL20, CCL3
35neutrophil chemotaxisGO:00305939.5CCL2, CCL20, CCL3
36MAPK cascadeGO:00001659.4CCL2, CCL3, IL2RA, TNF
37cytokine-mediated signaling pathwayGO:00192219.3CCL2, IL17RA, IL1RAP, IL6
38monocyte chemotaxisGO:00025489.2CCL2, CCL20, CCL3, IL6
39cellular response to interferon-gammaGO:00713469.2CCL2, CCL20, CCL3, CIITA
40cell surface receptor signaling pathwayGO:00071669.2CCL2, CXCL10, IL17A, IL17RA, IL2RA
41cellular response to tumor necrosis factorGO:00713569.1CCL2, CCL20, CCL3, IL6
42cell-cell signalingGO:00072679.0AIMP1, CCL20, CCL3, CXCL10, IL17A
43cellular response to interleukin-1GO:00713478.9CCL2, CCL20, CCL3, IL17A, IL6
44cellular response to lipopolysaccharideGO:00712228.8CCL2, CCL20, CXCL10, IL6, TNF, TNFSF4
45chemokine-mediated signaling pathwayGO:00700988.8CCL2, CCL20, CCL3, CCR6, CXCL10
46chemotaxisGO:00069358.5AIMP1, CCL2, CCL20, CCL3, CCR6, CXCL10
47positive regulation of ERK1 and ERK2 cascadeGO:00703748.1CCL2, CCL20, CCL3, IL6, TNF
48immune responseGO:00069558.0CCL20, CCR6, CIITA, CXCL10, IL17A, IL1RAP
49signal transductionGO:00071657.6AIMP1, CCL2, CCL20, CCR6, CD69, CXCL10
50inflammatory responseGO:00069546.8AIMP1, CCL2, CCL20, CCL3, CIITA, CXCL10

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.0CCL2, CCL20, CCL3, CXCL10
2receptor bindingGO:00051028.8CCL2, CXCL10, IL17RA, IL6, TNFSF4
3cytokine activityGO:00051258.5AIMP1, CCL2, CCL20, IL17A, IL6, TNF

Sources for Stromal Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet