MCID: STR072
MIFTS: 45

Stromal Keratitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Stromal Keratitis

About this section
Sources:
30ICD10 via Orphanet, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Stromal Keratitis:

Name: Stromal Keratitis 53 67

Characteristics:

Orphanet epidemiological data:

53
stromal keratitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 53 
Rare eye diseases


External Ids:

Orphanet53 ORPHA137599
UMLS via Orphanet68 C1318020
ICD10 via Orphanet30 H16.3

Summaries for Stromal Keratitis

About this section
MalaCards based summary: Stromal Keratitis is related to keratitis and panner disease, and has symptoms including Array, Array and Array. An important gene associated with Stromal Keratitis is PAX6 (Paired Box 6), and among its related pathways are IL27-mediated signaling events and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Stromal Keratitis

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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.5
2panner disease10.5IL6, TNF
3chronic conjunctivitis10.5IL17A, IL17RA, TNF
4aortic arch interruption10.5IL6, TNF
5tricho odonto onycho dermal syndrome10.5IL17A, IL6, TNF
6gastroduodenal crohn's disease10.5IL17A, IL6, TNF
7keloids10.5IL17A, IL6, TNF
8cutaneous leishmaniasis10.5IL6, TNF
9orbital periostitis10.5IL17A, IL6, TNF
10corneal intraepithelial neoplasm10.5IL17A, IL6, TNF
11reproductive system disease10.5IL17A, IL6, TNF
12maligant granulosa cell tumor of ovary10.5IL6, TNF
13herpes simplex10.4
14burn scar10.4IL17A, IL6, TNF
15crohn's colitis10.4IL2RA, TNF
16parametrium malignant neoplasm10.4IL17A, IL6, TNF
17atypical depressive disorder10.4CXCL10, IL6, TNF
18lung sarcoma10.4IL17A, IL6, TNF
19stone in bladder diverticulum10.4PAX6, TNF
20blood group incompatibility10.4IL17A, IL6, TNF
21hemometra10.4IL6, TNF
22polyradiculoneuropathy10.4IL17A, IL2RA, IL6
23toxic maculopathy10.4CXCL10, IL2RA, TNF
24rectum leiomyosarcoma10.4IL17A, IL6, TNF
25retroperitoneal fibrosis10.4IL2RA, IL6, TNF
26baetz-greenwalt syndrome10.4CIITA, TNF
27esophagus melanoma10.4IL2RA, IL6, TNF
28opportunistic bacterial infectious disease10.4CXCL10, IL6, TNF
29perianal skin paget's disease10.4IL17A, IL6, TNF
30graft-versus-host disease, protection against10.4IL2RA, TNF
31taylor's syndrome10.4CXCL10, IL6, TNF
32antigen-peptide-transporter 2 deficiency10.3CCL2, IL6, TNF
33secondary lacrimal atrophy10.3CCL2, CXCL10, TNF
34progressive relapsing multiple sclerosis10.3CCL2, CXCL10, IL17A
35osmotic diarrhea10.3CCL2, IL6, TNF
36inner ear disease10.3CCL2, CXCL10, TNF
37alopecia10.3CCL2, IL6, TNF
38neonatal period electroclinical syndrome10.3CCL2, IL6, TNF
39spondylolysis10.3CCL2, IL6, TNF
40renal tubular acidosis10.3CCL2, IL2RA, TNF
41diphtheria10.3CCL2, IL6, TNF
42esophagus squamous cell papilloma10.3CXCL10, IL6, TNF
43asbestosis10.3CCL2, IL6, TNF
44scrotum paget's disease10.3IL6, TNF
45night blindness10.3IL17A, TNF
46lung hilum cancer10.2CCL2, IL6, TNF
47short bowel syndrome10.2CCL2, IL6, TNF
48mixed lacrimal gland cancer10.2CCL2, IL6, TNF
49histoplasmosis pericarditis10.2CCL2, IL6, TNF
50atypical follicular adenoma10.2CCL2, IL6, TNF

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms for Stromal Keratitis

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Human phenotypes related to Stromal Keratitis:

 53 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 reduced visual acuity53 Very frequent (99-80%)
2 deep anterior chamber53 Very frequent (99-80%)
3 corneal stromal edema53 Very frequent (99-80%)
4 primary open angle glaucoma53 Very frequent (99-80%)
5 increased lacrimation53 Frequent (79-30%)
6 descemet membrane folds53 Frequent (79-30%)
7 decreased corneal sensation53 Frequent (79-30%)
8 corneal perforation53 Frequent (79-30%)
9 keratitis53 Occasional (29-5%)
10 blindness53 Occasional (29-5%)

Drugs & Therapeutics for Stromal Keratitis

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Drugs for Stromal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Methylprednisoloneapproved, vet_approvedPhase 3115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
2
Prednisoloneapproved, vet_approvedPhase 3115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3Peripheral Nervous System AgentsPhase 322776
4Neuroprotective AgentsPhase 31672
5AcyclovirPhase 3178
6Protective AgentsPhase 37190
7Prednisolone phosphatePhase 31153
8Prednisolone hemisuccinatePhase 31153
9Methylprednisolone HemisuccinatePhase 31153
10Prednisolone acetatePhase 31153
11AntiemeticsPhase 33888
12Methylprednisolone acetatePhase 31153
13Antiviral AgentsPhase 39732
14Anti-Infective AgentsPhase 321402
15HormonesPhase 313979
16Autonomic AgentsPhase 39774
17Gastrointestinal AgentsPhase 38109
18
Folic Acidapproved, nutraceutical, vet_approved427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
19
Riboflavinapproved, nutraceutical, vet_approved16583-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
20Trace Elements5802
21Vitamins5095
22Vitamin B Complex4229
23Dermatologic Agents5674
24Photosensitizing Agents476
25Micronutrients5802
26Vitamin B9Nutraceutical4279
27FolateNutraceutical4279
28Vitamin B2Nutraceutical165

Interventional clinical trials:

idNameStatusNCT IDPhase
1Herpetic Eye Disease Study (HEDS) IUnknown statusNCT00000138Phase 3
2Herpetic Eye Disease Study (HEDS) IICompletedNCT00000139Phase 3
3Cross Linking for Treatment of Corneal InfectionTerminatedNCT00912509

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

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MalaCards organs/tissues related to Stromal Keratitis:

35
Eye, T cells, Endothelial, Neutrophil, B cells, Lymph node, Skin

Animal Models for Stromal Keratitis or affiliated genes

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MGI Mouse Phenotypes related to Stromal Keratitis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CCR6, CD69, CIITA, CXCL10, IL17A, IL17RA
2MP:00053876.2AIMP1, CCL2, CCR6, CD69, CIITA, CXCL10

Publications for Stromal Keratitis

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Articles related to Stromal Keratitis:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. (27977029)
2016
2
Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. (27684823)
2016
3
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). (27257731)
2016
4
Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study. (26590045)
2015
5
Idiopathic stromal keratitis resembling central toxic keratopathy. (26210054)
2015
6
Microsporidial stromal keratitis masquerading as acute graft rejection. (25533000)
2015
7
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. (25859798)
2015
8
Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis. (26720197)
2015
9
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. (24651695)
2014
10
Correlation between matrix metalloproteinase expression and activation of the focal adhesion kinase signaling pathway in herpes stromal keratitis. (24348806)
2014
11
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
12
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
13
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
14
Elevated intraocular pressure-induced interlamellar stromal keratitis occurring 9 years after laser in situ keratomileusis. (21941173)
2012
15
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
16
Management of herpes simplex virus stromal keratitis: an evidence-based review. (19298901)
2009
17
Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis. (18689698)
2008
18
Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. (18580272)
2008
19
Interferon gamma is not required for recurrent herpetic stromal keratitis. (18755490)
2008
20
Granulocyte macrophage colony-stimulating factor expression in human herpetic stromal keratitis: implications for the role of neutrophils in HSK. (17197544)
2007
21
Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects. (16951377)
2006
22
Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines. (16178874)
2005
23
Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (16249483)
2005
24
Chronic microsporidial stromal keratitis in an immunocompetent, non-contact lens wearer. (15976469)
2005
25
Is microsporidial keratitis an emerging cause of stromal keratitis? A case series study. (16105181)
2005
26
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
27
Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis. (15585885)
2004
28
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. (12421973)
2002
29
Spontaneous reduction in myopic correction following varicella disciform stromal keratitis. (12140227)
2002
30
Topical administration of HSV gD-IL-2 DNA is highly protective against murine herpetic stromal keratitis. (11805518)
2002
31
Herpetic stromal keratitis in the absence of viral antigen recognition. (12576029)
2002
32
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
33
Stromal keratitis and anterior uveitis due to herpes simplex virus-2 in a young child. (11754904)
2001
34
Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (10922194)
2000
35
Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells. (10937573)
2000
36
Control of herpetic stromal keratitis using CTLA4Ig fusion protein. (9434800)
1998
37
Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis. (9557652)
1998
38
Topical cyclosporin as an adjunct to topical acyclovir treatment in herpetic stromal keratitis. (9380342)
1997
39
Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group. (8976723)
1996
40
Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. (7561104)
1995
41
Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. (8051423)
1994
42
Passive transfer of anti-herpes simplex virus type 2 monoclonal and polyclonal antibodies protect against herpes simplex virus type 1-induced but not herpes simplex virus type 2-induced stromal keratitis. (8392037)
1993
43
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
44
Obstinate cases of stromal keratitis treated by combined traditional Chinese and Western medicine. (1453751)
1992
45
Effects of 9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) eye drops and cyclosporine eye drops in the treatment of herpetic stromal keratitis in rabbits. (1650668)
1991
46
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
47
Quantitation of purified monoclonal antibody needed to prevent HSV-1 induced stromal keratitis in mice. (2736955)
1989
48
Corneal endothelial changes associated with herpetic stromal keratitis. (3411807)
1988
49
Clinical, pathologic, and immunopathologic characteristics of experimental murine herpes simplex virus stromal keratitis and uveitis is controlled by gene products from the Igh-1 locus on chromosome 12. (3128902)
1987
50
Corticosteroid therapy in central stromal keratitis. (4182154)
1969

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7IL17A, IL6, TNF
29.7IL17RA, IL6, TNF
39.7IL2RA, IL6, TNF
49.7IL2RA, IL6, TNFSF4
59.6IL6, TNF, TRB
69.6CCL2, IL6, TNF
79.6CCL2, IL6, TNF
89.5IL1RAP, TNF, TRB
9
Show member pathways
9.4CCL2, IL17A, IL6, TNF
10
Show member pathways
9.4CCL3, IL2RA, TNF
119.3CCR6, IL2RA, IL6, TNF
129.3CCL2, CXCL10, IL6, TNF
139.3CCL2, CCL3, TNF
14
Show member pathways
9.2IL17A, IL17RA, IL1RAP, IL6
159.2CD69, IL2RA, IL6, TNF
168.8CCL3, CCR6, IL17A, IL2RA, TNF
17
Show member pathways
8.7CCL2, CCL3, CXCL10, IL6, TNF
188.7CCL2, CIITA, CXCL10, IL2RA, TNF, TNFSF4
19
Show member pathways
8.6CCL2, CIITA, CXCL10, IL2RA, IL6, TNF
208.5CCL2, CCL20, CXCL10, IL6, TNF
21
Show member pathways
8.4CCL20, CXCL10, IL1RAP, IL6, TNF
22
Show member pathways
8.0CCL2, CCL20, CCL3, CCR6, CXCL10
237.9CCL2, CCL20, CCL3, IL17A, IL6, TNF
24
Show member pathways
7.9CCL2, CCL20, CCL3, IL17A, IL2RA, IL6
25
Show member pathways
7.6CCL2, CCL20, CCL3, IL17A, IL2RA, IL6
267.4CCL2, CCL20, CCL3, CXCL10, IL17A, IL6
27
Show member pathways
6.5CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
28
Show member pathways
6.5CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
29
Show member pathways
6.3CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
30
Show member pathways
6.1CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A

GO Terms for genes affiliated with Stromal Keratitis

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Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.8CD69, CXCL10, IL17A, IL2RA, IL6, TNF
2cell surfaceGO:00099868.5AIMP1, CCR6, CIITA, IL2RA, TNF, TNFSF4
3extracellular spaceGO:00056156.7AIMP1, CCL2, CCL20, CCL3, CXCL10, IL17A
4extracellular regionGO:00055766.3CCL2, CCL20, CCL3, CXCL10, IL17A, IL17RA

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:007253710.7IL17A, IL17RA
2positive regulation of cytokine production involved in inflammatory responseGO:190001710.7IL17A, IL17RA
3epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.7IL6, TNF
4positive regulation of immunoglobulin secretionGO:005102410.7IL6, TNFSF4
5positive regulation of T-helper 2 cell differentiationGO:004563010.6IL6, TNFSF4
6positive regulation of interleukin-23 productionGO:003274710.6IL17A, IL17RA
7negative regulation of cytokine secretionGO:005071010.6IL6, TNFSF4
8negative regulation of lipid storageGO:001088810.6IL6, TNF
9positive regulation of interleukin-13 productionGO:003273610.5IL1RAP, TNFSF4
10regulation of vascular endothelial growth factor productionGO:001057410.5CCL2, IL6
11response to auditory stimulusGO:001099610.5CXCL10, IL6
12positive regulation of monocyte chemotaxisGO:009002610.4CCL2, CXCL10
13leukocyte migration involved in inflammatory responseGO:000252310.4CCL2, CCR6
14negative regulation of collagen biosynthetic processGO:003296610.3CIITA, IL6
15granulocyte chemotaxisGO:007162110.3CCL3, IL17RA
16positive regulation of interleukin-6 productionGO:003275510.2IL6, TNF, TNFSF4
17response to glucocorticoidGO:005138410.2CCL2, IL6, TNF
18response to amino acidGO:004320010.2CCL2, IL17A, IL6
19astrocyte cell migrationGO:004361510.1CCL2, CCL3
20positive regulation of T cell proliferationGO:004210210.1IL2RA, IL6, TNFSF4
21T cell chemotaxisGO:001081810.1CCL3, CXCL10
22macrophage chemotaxisGO:004824610.1CCL2, CCL3
23T cell migrationGO:007267810.0CCL20, CCR6
24thymocyte migrationGO:007267910.0CCL20, CCR6
25positive regulation of T cell migrationGO:20004069.9CCL20, CXCL10
26protein kinase B signalingGO:00434919.9CCL2, CCL3, TNF
27lipopolysaccharide-mediated signaling pathwayGO:00316639.9CCL2, CCL3, TNF
28positive regulation of protein kinase B signalingGO:00518979.9CCL3, IL6, TNF
29humoral immune responseGO:00069599.9CCL2, CCR6, IL6, TNF
30response to antibioticGO:00466779.9CCL2, CIITA, IL6
31response to woundingGO:00096119.8AIMP1, CCL2, IL6, PAX6
32cellular response to organic cyclic compoundGO:00714079.7CCL2, CCL3, TNF
33positive regulation of inflammatory responseGO:00507299.6CCL2, CCL3, IL17RA, TNFSF4
34cytokine-mediated signaling pathwayGO:00192219.6CCL2, IL17RA, IL1RAP, IL6
35cell surface receptor signaling pathwayGO:00071669.4CCL2, CXCL10, IL17A, IL17RA, IL2RA
36MAPK cascadeGO:00001659.2CCL2, CCL3, IL2RA, TNF
37lymphocyte chemotaxisGO:00482479.2CCL2, CCL20, CCL3
38neutrophil chemotaxisGO:00305939.2CCL2, CCL20, CCL3
39monocyte chemotaxisGO:00025489.0CCL2, CCL20, CCL3, IL6
40cellular response to tumor necrosis factorGO:00713568.8CCL2, CCL20, CCL3, IL6
41cellular response to lipopolysaccharideGO:00712228.8CCL2, CCL20, CXCL10, IL6, TNF, TNFSF4
42cellular response to interferon-gammaGO:00713468.8CCL2, CCL20, CCL3, CIITA
43cell-cell signalingGO:00072678.7AIMP1, CCL20, CCL3, CXCL10, IL17A
44cellular response to interleukin-1GO:00713478.7CCL2, CCL20, CCL3, IL17A, IL6
45chemokine-mediated signaling pathwayGO:00700988.4CCL2, CCL20, CCL3, CCR6, CXCL10
46chemotaxisGO:00069358.1AIMP1, CCL2, CCL20, CCL3, CCR6, CXCL10
47positive regulation of ERK1 and ERK2 cascadeGO:00703747.8CCL2, CCL20, CCL3, IL6, TNF
48immune responseGO:00069557.7CCL20, CCR6, CIITA, CXCL10, IL17A, IL1RAP
49signal transductionGO:00071657.7AIMP1, CCL2, CCL20, CCR6, CD69, CXCL10
50inflammatory responseGO:00069546.4AIMP1, CCL2, CCL20, CCL3, CIITA, CXCL10

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.0CCL2, CXCL10, IL17RA, IL6, TNFSF4
2chemokine activityGO:00080098.6CCL2, CCL20, CCL3, CXCL10
3cytokine activityGO:00051258.3AIMP1, CCL2, CCL20, IL17A, IL6, TNF

Sources for Stromal Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet