MCID: STR072
MIFTS: 47

Stromal Keratitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Stromal Keratitis

MalaCards integrated aliases for Stromal Keratitis:

Name: Stromal Keratitis 56 69

Characteristics:

Orphanet epidemiological data:

56
stromal keratitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA137599
UMLS via Orphanet 70 C1318020
ICD10 via Orphanet 34 H16.3

Summaries for Stromal Keratitis

MalaCards based summary : Stromal Keratitis is related to keratitis and smarca4-deficient sarcoma of thorax, and has symptoms including reduced visual acuity, deep anterior chamber and corneal stromal edema. An important gene associated with Stromal Keratitis is PAX6 (Paired Box 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are hematopoietic system and immune system

Related Diseases for Stromal Keratitis

Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
id Related Disease Score Top Affiliating Genes
1 keratitis 11.5
2 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
3 aortic arch interruption 10.7 IL6 TNF
4 lung disease 10.7 IL17A TNF
5 cutaneous leishmaniasis 10.6 IL6 TNF
6 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.6 IL17A IL2RA
7 motor peripheral neuropathy 10.6 IL17A IL17RA TNF
8 central nervous system leiomyosarcoma 10.6 IL17A IL6 TNF
9 tricho onychic dysplasia 10.6 IL17A IL6 TNF
10 tracheal stenosis 10.6 IL17A IL6 TNF
11 keloids 10.6 IL17A IL6 TNF
12 gastroduodenal crohn's disease 10.6 IL17A IL6 TNF
13 c1 inhibitor deficiency 10.6 IL17A IL6 TNF
14 orbital osteomyelitis 10.6 IL17A IL6 TNF
15 disease of mental health 10.6 IL17A IL6 TNF
16 cornea cancer 10.6 IL17A IL6 TNF
17 spirillary rat-bite fever 10.6 IL6 TNF
18 burn scar 10.6 IL17A IL6 TNF
19 sternal cleft 10.6 CIITA TNF
20 uterine adnexa cancer 10.6 IL17A IL6 TNF
21 vogt-koyanagi-harada disease 10.6 CXCL10 IL6 TNF
22 primary systemic mycosis 10.5 IL17A TNF
23 crohn's colitis 10.5 IL2RA TNF
24 cyclosporiasis 10.5 IL2RA IL6 TNF
25 cerebellar disease 10.5 IL17A IL6 TNF
26 dysphagia 10.5 IL2RA IL6 TNF
27 endometrial clear cell adenocarcinoma 10.5 IL17A IL6 TNF
28 abnormal retinal correspondence 10.5 CXCL10 IL6 TNF
29 lymphoma 10.5 IL17A IL6 TNF
30 muscle tissue disease 10.5 IL17A IL6 TNF
31 intestinal disaccharidase deficiency 10.5 CXCL10 IL2RA TNF
32 iida kannari syndrome 10.5 IL2RA IL6 TNF
33 esophagus melanoma 10.5 IL2RA IL6 TNF
34 lacrimal system cancer 10.5 IL17A IL6 TNF
35 toxoplasmosis 10.5 IL6 TNF
36 herpes simplex 10.5
37 antigen-peptide-transporter 2 deficiency 10.4 CCL2 IL6 TNF
38 islet cell tumor 10.4 CCL2 IL6 TNF
39 autoimmune retinopathy 10.4 IL2RA TNF
40 tuberculum sellae meningioma 10.4 IL17A IL6 TNF
41 status epilepticus 10.4 CCL2 CXCL10 TNF
42 pulmonary tuberculosis 10.4 CCL2 CXCL10 TNF
43 myofascial pain syndrome 10.4 CCL2 IL17A IL6
44 high pressure neurological syndrome 10.4 CCL2 IL6 TNF
45 osmotic diarrhea 10.4 CCL2 IL6 TNF
46 atrophy of prostate 10.4 CCL2 IL6 TNF
47 choroiditis 10.4 CCL2 IL6 TNF
48 renal tubular acidosis 10.4 CCL2 IL2RA TNF
49 neonatal period electroclinical syndrome 10.4 CCL2 IL6 TNF
50 kaposi sarcoma 10.3 IL2RA IL6 TNF

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to Stromal Keratitis

Symptoms & Phenotypes for Stromal Keratitis

Human phenotypes related to Stromal Keratitis:

56 32 (show all 12)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 reduced visual acuity 56 32 hallmark (90%) Very frequent (99-80%) HP:0007663
2 deep anterior chamber 56 32 hallmark (90%) Very frequent (99-80%) HP:0007765
3 corneal stromal edema 56 32 hallmark (90%) Very frequent (99-80%) HP:0012040
4 herpetiform corneal ulceration 56 32 frequent (33%) Frequent (79-30%) HP:0007812
5 increased lacrimation 56 32 frequent (33%) Frequent (79-30%) HP:0009926
6 descemet membrane folds 56 32 frequent (33%) Frequent (79-30%) HP:0012039
7 decreased corneal sensation 56 32 frequent (33%) Frequent (79-30%) HP:0012155
8 corneal perforation 56 32 frequent (33%) Frequent (79-30%) HP:0100583
9 keratitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0000491
10 blindness 56 32 occasional (7.5%) Occasional (29-5%) HP:0000618
11 primary open angle glaucoma 56 Very frequent (99-80%)
12 open angle glaucoma 32 hallmark (90%) HP:0012108

MGI Mouse Phenotypes related to Stromal Keratitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 CIITA CXCL10 IL17A IL17RA IL2RA IL6
2 immune system MP:0005387 9.47 CIITA CXCL10 IL17A IL17RA IL1RAP IL2RA

Drugs & Therapeutics for Stromal Keratitis

Drugs for Stromal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acyclovir Phase 4,Phase 3
2 Anti-Infective Agents Phase 4,Phase 3
3 Antiviral Agents Phase 4,Phase 3
4 valacyclovir Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7 Antiemetics Phase 3
8 Autonomic Agents Phase 3
9 Gastrointestinal Agents Phase 3
10 Hormones Phase 3
11 Methylprednisolone acetate Phase 3
12 Methylprednisolone Hemisuccinate Phase 3
13 Neuroprotective Agents Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Prednisolone acetate Phase 3
16 Prednisolone hemisuccinate Phase 3
17 Prednisolone phosphate Phase 3
18 Protective Agents Phase 3
19
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
20
Riboflavin Approved, Nutraceutical, Vet_approved 83-88-5 493570
21 Dermatologic Agents
22 Micronutrients
23 Photosensitizing Agents
24 Trace Elements
25 Vitamin B Complex
26 Vitamins
27 Folate Nutraceutical
28 Vitamin B2 Nutraceutical
29 Vitamin B9 Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Zoster Eye Disease Study Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
2 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
3 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir
4 Cross Linking for Treatment of Corneal Infection Terminated NCT00912509 riboflavin

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

Anatomical Context for Stromal Keratitis

MalaCards organs/tissues related to Stromal Keratitis:

39
Eye, T Cells, Endothelial, Neutrophil, B Cells, Lymph Node, Skin

Publications for Stromal Keratitis

Articles related to Stromal Keratitis:

(show top 50) (show all 226)
id Title Authors Year
1
Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation. ( 28513490 )
2017
2
Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function. ( 28100624 )
2017
3
Potential Clue to the Pathogenesis of Varicella-Zoster Virus Stromal Keratitis. ( 28799957 )
2017
4
CXCL9 compensates for the absence of CXCL10 during recurrent Herpetic stromal keratitis. ( 28282568 )
2017
5
Stromal keratitis in a neonate: Herpes virus a diagnosis to consider. ( 26710660 )
2016
6
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
7
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. ( 27849421 )
2016
8
Microsporidial Stromal Keratitis: Successful Treatment with Topical Voriconazole and Oral Itraconazole. ( 28123915 )
2016
9
Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. ( 27684823 )
2016
10
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). ( 27257731 )
2016
11
Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis. ( 26758184 )
2016
12
Microsporidial stromal keratitis and endophthalmitis in an immunocompetent patient. ( 27528053 )
2016
13
A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. ( 27070108 )
2016
14
Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis. ( 27275421 )
2016
15
Amniotic membrane transplantation in bacterial and herpetic stromal keratitis. ( 27511511 )
2016
16
Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis. ( 27798158 )
2016
17
Microsporidial Stromal Keratitis: Clinical Features, Unique Diagnostic Criteria, and Treatment Outcomes in a Large Case Series. ( 27467044 )
2016
18
Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty. ( 26989540 )
2016
19
Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology. ( 26507231 )
2015
20
Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis. ( 25785282 )
2015
21
Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. ( 26444718 )
2015
22
Do Unilateral Herpetic Stromal Keratitis and Neurotrophic Ulcers Cause Bilateral Dry Eye? ( 25933398 )
2015
23
Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. ( 25996419 )
2015
24
Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis. ( 26720197 )
2015
25
Role of miR-155 in the Pathogenesis of Herpetic Stromal Keratitis. ( 25700796 )
2015
26
Intrastromal bevacizumab injection for corneal neovascularization in herpetic stromal keratitis. ( 26342658 )
2015
27
Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study. ( 26590045 )
2015
28
Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis. ( 26555580 )
2015
29
IL-2/anti-IL-2 antibody complex treatment inhibits the development but not the progression of herpetic stromal keratitis. ( 25411200 )
2015
30
Prevention of herpes simplex virus induced stromal keratitis by a glycoprotein B-specific monoclonal antibody. ( 25587898 )
2015
31
Microsporidial stromal keratitis masquerading as acute graft rejection. ( 25533000 )
2015
32
Idiopathic stromal keratitis resembling central toxic keratopathy. ( 26210054 )
2015
33
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. ( 25859798 )
2015
34
Corneal lymphangiogenesis in herpetic stromal keratitis. ( 25444520 )
2015
35
Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice. ( 26504854 )
2015
36
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia. ( 25826328 )
2015
37
CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. ( 24442436 )
2014
38
Varicella-zoster virus detection in varicella-associated stromal keratitis. ( 24723158 )
2014
39
Reversible nerve damage and corneal pathology in murine herpes simplex stromal keratitis. ( 24789786 )
2014
40
Correlation between matrix metalloproteinase expression and activation of the focal adhesion kinase signaling pathway in herpes stromal keratitis. ( 24348806 )
2014
41
A young immunocompetent patient with bilateral immune stromal keratitis due to varicella zoster and herpes simplex. ( 24985896 )
2014
42
Herpes zoster stromal keratitis after varicella vaccine booster in a pediatric patient. ( 25062334 )
2014
43
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. ( 24651695 )
2014
44
Pressure-induced stromal keratitis. ( 23479805 )
2013
45
Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization. ( 22892644 )
2013
46
Pressure-induced interlamellar stromal keratitis after vitreoretinal surgery. ( 25390813 )
2013
47
Unilateral posterior stromal keratitis possibly secondary to Lyme disease. ( 23132459 )
2013
48
Potential function of miRNAs in herpetic stromal keratitis. ( 23329734 )
2013
49
Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice. ( 23720717 )
2013
50
Controlling herpetic stromal keratitis by modulating lymphotoxin-alpha-mediated inflammatory pathways. ( 23850656 )
2013

Variations for Stromal Keratitis

Expression for Stromal Keratitis

Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for Stromal Keratitis

Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CCL2 CCL20 CCL3 CCR6 CIITA CXCL10
2
Show member pathways
13.78 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
3
Show member pathways
13.55 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
4
Show member pathways
13.29 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
5
Show member pathways
13.13 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
6
Show member pathways
13.04 CCL2 CCL20 CCL3 CIITA CXCL10 IL17A
7
Show member pathways
12.82 CCL2 CCL20 CCL3 CCR6 CXCL10
8
Show member pathways
12.82 CCL2 CCL3 CXCL10 IL6 TNF
9
Show member pathways
12.79 CIITA IL17A IL2RA IL6 TNF
10
Show member pathways
12.77 CCL2 CIITA CXCL10 IL2RA IL6 TNF
11
Show member pathways
12.57 IL17A IL1RAP IL2RA IL6 TNF TRB
12 12.5 CCL2 CIITA CXCL10 IL17A IL2RA TNF
13
Show member pathways
12.37 IL17A IL6 TNF TRB
14
Show member pathways
12.24 CCL2 CCL20 CXCL10 IL17A IL17RA IL6
15
Show member pathways
12.14 CCL20 CXCL10 IL1RAP IL6 TNF
16 12 CCL2 CXCL10 IL6 TNF
17
Show member pathways
12 CCL2 CCL20 CCL3 CCR6 CXCL10
18 11.99 CD69 IL2RA IL6 TNF
19 11.96 CCL2 IL17A IL6 TNF
20 11.93 CCL2 CCL20 CXCL10 IL6 TNF
21
Show member pathways
11.9 IL17A IL17RA IL1RAP IL6
22
Show member pathways
11.88 IL17A IL6 TNF
23 11.84 CCL2 IL6 TNF
24 11.83 IL2RA IL6 TNF
25
Show member pathways
11.81 IL17A IL17RA IL6
26 11.78 CCL3 CCR6 IL17A IL2RA TNF
27 11.71 IL17RA IL6 TNF
28 11.71 CCR6 IL2RA IL6 TNF
29 11.69 CCL2 CCL20 CCL3 IL17A IL6 TNF
30 11.65 CCL2 CCL3 IL6 TNF
31 11.55 IL1RAP TNF TRB
32 11.5 CCL2 IL6 TNF
33
Show member pathways
11.41 CCL3 IL2RA TNF
34 11.31 IL17A IL6 TNF
35 11.26 IL6 TNF TRB
36 11.12 CCL2 CCL20 CCL3 CXCL10 IL6 TNF
37 10.96 CCL2 CCL3 TNF
38 10.46 CCL2 CCL20 CCL3 CXCL10 IL17A IL6

GO Terms for Stromal Keratitis

Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 AIMP1 CCL2 CCL20 CCL3 CXCL10 IL17A
2 cell surface GO:0009986 9.73 AIMP1 CCR6 CIITA IL2RA TNF TNFSF4
3 external side of plasma membrane GO:0009897 9.43 CD69 CXCL10 IL17A IL2RA IL6 TNF
4 extracellular space GO:0005615 9.36 AIMP1 CCL2 CCL20 CCL3 CXCL10 IL17A

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.99 CCL2 CCL3 IL2RA TNF
2 cell surface receptor signaling pathway GO:0007166 9.99 CCL2 CXCL10 IL17RA IL2RA
3 cell-cell signaling GO:0007267 9.99 AIMP1 CCL20 CCL3 CXCL10 IL17A
4 cytokine-mediated signaling pathway GO:0019221 9.91 CCL2 IL17RA IL1RAP IL6
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 CCL20 CCL3 IL6 TNF
6 positive regulation of protein kinase B signaling GO:0051897 9.87 CCL3 IL6 TNF
7 cellular response to tumor necrosis factor GO:0071356 9.86 CCL2 CCL20 CCL3 IL6
8 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 CCL3 TNF
9 response to glucocorticoid GO:0051384 9.84 CCL2 IL6 TNF
10 neutrophil chemotaxis GO:0030593 9.83 CCL2 CCL20 CCL3
11 positive regulation of inflammatory response GO:0050729 9.83 CCL3 IL17RA TNFSF4
12 positive regulation of T cell proliferation GO:0042102 9.81 IL2RA IL6 TNFSF4
13 response to wounding GO:0009611 9.8 AIMP1 CCL2 IL6 PAX6
14 cellular response to interleukin-1 GO:0071347 9.8 CCL2 CCL20 CCL3 IL17A IL6
15 positive regulation of interleukin-6 production GO:0032755 9.79 IL6 TNF TNFSF4
16 cellular response to interferon-gamma GO:0071346 9.78 CCL2 CCL20 CCL3 CIITA
17 chemokine-mediated signaling pathway GO:0070098 9.77 CCL2 CCL20 CCL3 CCR6 CXCL10
18 humoral immune response GO:0006959 9.76 CCL2 CCR6 IL6 TNF
19 response to antibiotic GO:0046677 9.75 CCL2 CIITA IL6
20 protein kinase B signaling GO:0043491 9.74 CCL2 CCL3 TNF
21 monocyte chemotaxis GO:0002548 9.73 CCL2 CCL20 CCL3 IL6
22 chemotaxis GO:0006935 9.73 AIMP1 CCL2 CCL20 CCL3 CCR6 CXCL10
23 immune response GO:0006955 9.73 CCL2 CCL20 CCL3 CCR6 CIITA CXCL10
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 CCL2 CCL3 TNF
25 cell chemotaxis GO:0060326 9.72 CCL2 CCL20 CCL3 CCR6 CXCL10
26 positive regulation of chemokine production GO:0032722 9.71 IL6 TNF
27 positive regulation of calcium ion import GO:0090280 9.71 CCL2 CCL3
28 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 IL17A IL17RA
29 positive regulation of T cell migration GO:2000406 9.71 CCL20 CXCL10
30 lymphocyte chemotaxis GO:0048247 9.71 CCL2 CCL20 CCL3
31 negative regulation of collagen biosynthetic process GO:0032966 9.7 CIITA IL6
32 acute inflammatory response GO:0002526 9.7 IL6 TNFSF4
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 CCL2 CCL20
34 macrophage chemotaxis GO:0048246 9.69 CCL2 CCL3
35 negative regulation of cytokine secretion GO:0050710 9.68 IL6 TNFSF4
36 response to auditory stimulus GO:0010996 9.68 CXCL10 IL6
37 positive regulation of immunoglobulin secretion GO:0051024 9.68 IL6 TNFSF4
38 T cell chemotaxis GO:0010818 9.68 CCL3 CXCL10
39 leukocyte migration involved in inflammatory response GO:0002523 9.67 CCL2 CCR6
40 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
41 T cell migration GO:0072678 9.65 CCL20 CCR6
42 positive regulation of interleukin-13 production GO:0032736 9.65 IL1RAP TNFSF4
43 positive regulation of T-helper 2 cell differentiation GO:0045630 9.64 IL6 TNFSF4
44 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.63 IL6 TNF
45 astrocyte cell migration GO:0043615 9.63 CCL2 CCL3
46 cellular response to lipopolysaccharide GO:0071222 9.63 CCL2 CCL20 CXCL10 IL6 TNF TNFSF4
47 positive regulation of interleukin-23 production GO:0032747 9.62 IL17A IL17RA
48 granulocyte chemotaxis GO:0071621 9.62 CCL3 IL17RA
49 regulation of vascular endothelial growth factor production GO:0010574 9.6 CCL2 IL6
50 fibroblast activation GO:0072537 9.58 IL17A IL17RA

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.55 CCL2 CXCL10 IL17RA IL6 TNFSF4
2 cytokine activity GO:0005125 9.28 AIMP1 CCL2 CCL20 CCL3 CXCL10 IL17A
3 chemokine activity GO:0008009 9.26 CCL2 CCL20 CCL3 CXCL10

Sources for Stromal Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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