MCID: STR072
MIFTS: 45

Stromal Keratitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Stromal Keratitis

About this section
Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Stromal Keratitis:

Name: Stromal Keratitis 54 68

Characteristics:

Orphanet epidemiological data:

54
stromal keratitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Orphanet54 ORPHA137599
UMLS via Orphanet69 C1318020
ICD10 via Orphanet31 H16.3

Summaries for Stromal Keratitis

About this section
MalaCards based summary: Stromal Keratitis is related to keratitis and panner disease, and has symptoms including Array, Array and Array. An important gene associated with Stromal Keratitis is PAX6 (Paired Box 6), and among its related pathways are IL27-mediated signaling events and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Stromal Keratitis

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Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis11.5
2panner disease10.5IL6, TNF
3chronic conjunctivitis10.5IL17A, IL17RA, TNF
4aortic arch interruption10.5IL6, TNF
5tricho odonto onycho dermal syndrome10.5IL17A, IL6, TNF
6gastroduodenal crohn's disease10.5IL17A, IL6, TNF
7keloids10.5IL17A, IL6, TNF
8cutaneous leishmaniasis10.5IL6, TNF
9orbital periostitis10.5IL17A, IL6, TNF
10corneal intraepithelial neoplasm10.5IL17A, IL6, TNF
11reproductive system disease10.5IL17A, IL6, TNF
12maligant granulosa cell tumor of ovary10.5IL6, TNF
13herpes simplex10.4
14burn scar10.4IL17A, IL6, TNF
15crohn's colitis10.4IL2RA, TNF
16parametrium malignant neoplasm10.4IL17A, IL6, TNF
17atypical depressive disorder10.4CXCL10, IL6, TNF
18lung sarcoma10.4IL17A, IL6, TNF
19stone in bladder diverticulum10.4PAX6, TNF
20blood group incompatibility10.4IL17A, IL6, TNF
21hemometra10.4IL6, TNF
22polyradiculoneuropathy10.4IL17A, IL2RA, IL6
23toxic maculopathy10.4CXCL10, IL2RA, TNF
24rectum leiomyosarcoma10.4IL17A, IL6, TNF
25retroperitoneal fibrosis10.4IL2RA, IL6, TNF
26baetz-greenwalt syndrome10.4CIITA, TNF
27esophagus melanoma10.4IL2RA, IL6, TNF
28opportunistic bacterial infectious disease10.4CXCL10, IL6, TNF
29perianal skin paget's disease10.4IL17A, IL6, TNF
30graft-versus-host disease, protection against10.4IL2RA, TNF
31taylor's syndrome10.4CXCL10, IL6, TNF
32antigen-peptide-transporter 2 deficiency10.3CCL2, IL6, TNF
33secondary lacrimal atrophy10.3CCL2, CXCL10, TNF
34progressive relapsing multiple sclerosis10.3CCL2, CXCL10, IL17A
35osmotic diarrhea10.3CCL2, IL6, TNF
36inner ear disease10.3CCL2, CXCL10, TNF
37alopecia10.3CCL2, IL6, TNF
38neonatal period electroclinical syndrome10.3CCL2, IL6, TNF
39spondylolysis10.3CCL2, IL6, TNF
40renal tubular acidosis10.3CCL2, IL2RA, TNF
41diphtheria10.3CCL2, IL6, TNF
42esophagus squamous cell papilloma10.3CXCL10, IL6, TNF
43asbestosis10.3CCL2, IL6, TNF
44scrotum paget's disease10.3IL6, TNF
45night blindness10.3IL17A, TNF
46lung hilum cancer10.2CCL2, IL6, TNF
47short bowel syndrome10.2CCL2, IL6, TNF
48mixed lacrimal gland cancer10.2CCL2, IL6, TNF
49histoplasmosis pericarditis10.2CCL2, IL6, TNF
50atypical follicular adenoma10.2CCL2, IL6, TNF

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to stromal keratitis

Symptoms & Phenotypes for Stromal Keratitis

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Human phenotypes related to Stromal Keratitis:

 54 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 reduced visual acuity54 Very frequent (99-80%)
2 deep anterior chamber54 Very frequent (99-80%)
3 corneal stromal edema54 Very frequent (99-80%)
4 primary open angle glaucoma54 Very frequent (99-80%)
5 increased lacrimation54 Frequent (79-30%)
6 descemet membrane folds54 Frequent (79-30%)
7 decreased corneal sensation54 Frequent (79-30%)
8 corneal perforation54 Frequent (79-30%)
9 keratitis54 Occasional (29-5%)
10 blindness54 Occasional (29-5%)

MGI Mouse Phenotypes related to Stromal Keratitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CCR6, CD69, CIITA, CXCL10, IL17A, IL17RA
2MP:00053876.2AIMP1, CCL2, CCR6, CD69, CIITA, CXCL10

Drugs & Therapeutics for Stromal Keratitis

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Drugs for Stromal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Methylprednisoloneapproved, vet_approvedPhase 3115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
2
Prednisoloneapproved, vet_approvedPhase 3115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3Peripheral Nervous System AgentsPhase 322776
4Neuroprotective AgentsPhase 31672
5AcyclovirPhase 3178
6Protective AgentsPhase 37190
7Prednisolone phosphatePhase 31153
8Prednisolone hemisuccinatePhase 31153
9Methylprednisolone HemisuccinatePhase 31153
10Prednisolone acetatePhase 31153
11AntiemeticsPhase 33888
12Methylprednisolone acetatePhase 31153
13Antiviral AgentsPhase 39732
14Anti-Infective AgentsPhase 321402
15HormonesPhase 313979
16Autonomic AgentsPhase 39774
17Gastrointestinal AgentsPhase 38109
18
Folic Acidapproved, nutraceutical, vet_approved427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
19
Riboflavinapproved, nutraceutical, vet_approved16583-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
20Trace Elements5802
21Vitamins5095
22Vitamin B Complex4229
23Dermatologic Agents5674
24Photosensitizing Agents476
25Micronutrients5802
26Vitamin B9Nutraceutical4279
27FolateNutraceutical4279
28Vitamin B2Nutraceutical165

Interventional clinical trials:

idNameStatusNCT IDPhase
1Herpetic Eye Disease Study (HEDS) IUnknown statusNCT00000138Phase 3
2Herpetic Eye Disease Study (HEDS) IICompletedNCT00000139Phase 3
3Cross Linking for Treatment of Corneal InfectionTerminatedNCT00912509

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

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Anatomical Context for Stromal Keratitis

About this section

MalaCards organs/tissues related to Stromal Keratitis:

36
Eye, T cells, Endothelial, Neutrophil, B cells, Lymph node, Skin

Publications for Stromal Keratitis

About this section

Articles related to Stromal Keratitis:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. (27977029)
2016
2
Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. (27684823)
2016
3
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). (27257731)
2016
4
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. (27849421)
2016
5
Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis. (27275421)
2016
6
A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. (27070108)
2016
7
Microsporidial Stromal Keratitis: Clinical Features, Unique Diagnostic Criteria, and Treatment Outcomes in a Large Case Series. (27467044)
2016
8
Amniotic membrane transplantation in bacterial and herpetic stromal keratitis. (27511511)
2016
9
Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis. (26758184)
2016
10
Microsporidial stromal keratitis and endophthalmitis in an immunocompetent patient. (27528053)
2016
11
Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty. (26989540)
2016
12
Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis. (27798158)
2016
13
Stromal keratitis in a neonate: Herpes virus a diagnosis to consider. (26710660)
2016
14
Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study. (26590045)
2015
15
Idiopathic stromal keratitis resembling central toxic keratopathy. (26210054)
2015
16
Microsporidial stromal keratitis masquerading as acute graft rejection. (25533000)
2015
17
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. (25859798)
2015
18
Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis. (26720197)
2015
19
IL-2/anti-IL-2 antibody complex treatment inhibits the development but not the progression of herpetic stromal keratitis. (25411200)
2015
20
Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. (25996419)
2015
21
Do Unilateral Herpetic Stromal Keratitis and Neurotrophic Ulcers Cause Bilateral Dry Eye? (25933398)
2015
22
Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology. (26507231)
2015
23
Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice. (26504854)
2015
24
Role of miR-155 in the Pathogenesis of Herpetic Stromal Keratitis. (25700796)
2015
25
Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. (26444718)
2015
26
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia. (25826328)
2015
27
Intrastromal bevacizumab injection for corneal neovascularization in herpetic stromal keratitis. (26342658)
2015
28
Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis. (25785282)
2015
29
Corneal lymphangiogenesis in herpetic stromal keratitis. (25444520)
2015
30
Prevention of herpes simplex virus induced stromal keratitis by a glycoprotein B-specific monoclonal antibody. (25587898)
2015
31
Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis. (26555580)
2015
32
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. (24651695)
2014
33
Correlation between matrix metalloproteinase expression and activation of the focal adhesion kinase signaling pathway in herpes stromal keratitis. (24348806)
2014
34
Reversible nerve damage and corneal pathology in murine herpes simplex stromal keratitis. (24789786)
2014
35
A young immunocompetent patient with bilateral immune stromal keratitis due to varicella zoster and herpes simplex. (24985896)
2014
36
Varicella-zoster virus detection in varicella-associated stromal keratitis. (24723158)
2014
37
Herpes zoster stromal keratitis after varicella vaccine booster in a pediatric patient. (25062334)
2014
38
CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. (24442436)
2014
39
Potential function of miRNAs in herpetic stromal keratitis. (23329734)
2013
40
Pressure-induced interlamellar stromal keratitis after vitreoretinal surgery. (25390813)
2013
41
Unilateral posterior stromal keratitis possibly secondary to Lyme disease. (23132459)
2013
42
Controlling herpetic stromal keratitis by modulating lymphotoxin-alpha-mediated inflammatory pathways. (23850656)
2013
43
Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization. (22892644)
2013
44
Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice. (23720717)
2013
45
Pressure-induced stromal keratitis. (23479805)
2013
46
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
47
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
48
Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy. (22361312)
2012
49
Elevated intraocular pressure-induced interlamellar stromal keratitis occurring 9 years after laser in situ keratomileusis. (21941173)
2012
50
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012

Variations for Stromal Keratitis

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Expression for genes affiliated with Stromal Keratitis

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Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for genes affiliated with Stromal Keratitis

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Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7IL17A, IL6, TNF
29.7IL17RA, IL6, TNF
39.7IL2RA, IL6, TNF
49.7IL2RA, IL6, TNFSF4
59.6IL6, TNF, TRB
69.6CCL2, IL6, TNF
79.6CCL2, IL6, TNF
89.5IL1RAP, TNF, TRB
9
Show member pathways
9.4CCL2, IL17A, IL6, TNF
10
Show member pathways
9.4CCL3, IL2RA, TNF
119.3CCR6, IL2RA, IL6, TNF
129.3CCL2, CXCL10, IL6, TNF
139.3CCL2, CCL3, TNF
14
Show member pathways
9.2IL17A, IL17RA, IL1RAP, IL6
159.2CD69, IL2RA, IL6, TNF
168.8CCL3, CCR6, IL17A, IL2RA, TNF
17
Show member pathways
8.7CCL2, CCL3, CXCL10, IL6, TNF
188.7CCL2, CIITA, CXCL10, IL2RA, TNF, TNFSF4
19
Show member pathways
8.6CCL2, CIITA, CXCL10, IL2RA, IL6, TNF
208.5CCL2, CCL20, CXCL10, IL6, TNF
21
Show member pathways
8.4CCL20, CXCL10, IL1RAP, IL6, TNF
22
Show member pathways
8.0CCL2, CCL20, CCL3, CCR6, CXCL10
237.9CCL2, CCL20, CCL3, IL17A, IL6, TNF
24
Show member pathways
7.9CCL2, CCL20, CCL3, IL17A, IL2RA, IL6
25
Show member pathways
7.6CCL2, CCL20, CCL3, IL17A, IL2RA, IL6
267.4CCL2, CCL20, CCL3, CXCL10, IL17A, IL6
27
Show member pathways
6.5CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
28
Show member pathways
6.5CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
29
Show member pathways
6.3CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A
30
Show member pathways
6.1CCL2, CCL20, CCL3, CCR6, CXCL10, IL17A

GO Terms for genes affiliated with Stromal Keratitis

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Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.5AIMP1, CCR6, CIITA, IL2RA, TNF, TNFSF4
2external side of plasma membraneGO:00098979.4CD69, CXCL10, IL17A, IL2RA, IL6, TNF
3extracellular regionGO:00055767.1CCL2, CCL20, CCL3, CXCL10, IL17A, IL17RA
4extracellular spaceGO:00056156.7AIMP1, CCL2, CCL20, CCL3, CXCL10, IL17A

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:007253710.8IL17A, IL17RA
2positive regulation of cytokine production involved in inflammatory responseGO:190001710.8IL17A, IL17RA
3positive regulation of interleukin-23 productionGO:003274710.8IL17A, IL17RA
4epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.8IL6, TNF
5acute inflammatory responseGO:000252610.7IL6, TNFSF4
6negative regulation of lipid storageGO:001088810.7IL6, TNF
7negative regulation of cytokine secretionGO:005071010.7IL6, TNFSF4
8positive regulation of immunoglobulin secretionGO:005102410.7IL6, TNFSF4
9positive regulation of T-helper 2 cell differentiationGO:004563010.7IL6, TNFSF4
10response to auditory stimulusGO:001099610.7CXCL10, IL6
11positive regulation of monocyte chemotaxisGO:009002610.6CCL2, CXCL10
12positive regulation of interleukin-13 productionGO:003273610.6IL1RAP, TNFSF4
13regulation of vascular endothelial growth factor productionGO:001057410.5CCL2, IL6
14negative regulation of collagen biosynthetic processGO:003296610.5CIITA, IL6
15leukocyte migration involved in inflammatory responseGO:000252310.5CCL2, CCR6
16positive regulation of interleukin-6 productionGO:003275510.5IL6, TNF, TNFSF4
17positive regulation of T cell proliferationGO:004210210.4IL2RA, IL6, TNFSF4
18granulocyte chemotaxisGO:007162110.4CCL3, IL17RA
19response to glucocorticoidGO:005138410.3CCL2, IL6, TNF
20response to amino acidGO:004320010.3CCL2, IL17A, IL6
21astrocyte cell migrationGO:004361510.3CCL2, CCL3
22macrophage chemotaxisGO:004824610.3CCL2, CCL3
23positive regulation of calcium ion importGO:009028010.3CCL2, CCL3
24positive regulation of T cell migrationGO:200040610.2CCL20, CXCL10
25response to antibioticGO:004667710.1CCL2, CIITA, IL6
26positive regulation of protein kinase B signalingGO:005189710.1CCL3, IL6, TNF
27response to woundingGO:000961110.1AIMP1, CCL2, IL6, PAX6
28cellular response to organic cyclic compoundGO:007140710.1CCL2, CCL3, TNF
29lipopolysaccharide-mediated signaling pathwayGO:003166310.1CCL2, CCL3, TNF
30positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.1CCL2, CCL20
31humoral immune responseGO:000695910.0CCL2, CCR6, IL6, TNF
32protein kinase B signalingGO:004349110.0CCL2, CCL3, TNF
33cytokine-mediated signaling pathwayGO:00192219.9CCL2, IL17RA, IL1RAP, IL6
34cell surface receptor signaling pathwayGO:00071669.9CCL2, CXCL10, IL17A, IL17RA, IL2RA
35T cell chemotaxisGO:00108189.8CCL3, CXCL10
36positive regulation of inflammatory responseGO:00507299.8CCL2, CCL3, IL17RA, TNFSF4
37MAPK cascadeGO:00001659.8CCL2, CCL3, IL2RA, TNF
38positive regulation of transcription from RNA polymerase II promoterGO:00459449.6CIITA, CXCL10, IL17A, IL6, PAX6, TNF
39lymphocyte chemotaxisGO:00482479.4CCL2, CCL20, CCL3
40neutrophil chemotaxisGO:00305939.4CCL2, CCL20, CCL3
41thymocyte migrationGO:00726799.3CCL20, CCR6
42T cell migrationGO:00726789.2CCL20, CCR6
43cellular response to tumor necrosis factorGO:00713569.2CCL2, CCL20, CCL3, IL6
44monocyte chemotaxisGO:00025489.1CCL2, CCL20, CCL3, IL6
45cell-cell signalingGO:00072679.1AIMP1, CCL20, CCL3, CXCL10, IL17A
46cellular response to lipopolysaccharideGO:00712229.1CCL2, CCL20, CXCL10, IL6, TNF, TNFSF4
47cellular response to interferon-gammaGO:00713469.0CCL2, CCL20, CCL3, CIITA
48cellular response to interleukin-1GO:00713478.9CCL2, CCL20, CCL3, IL17A, IL6
49positive regulation of ERK1 and ERK2 cascadeGO:00703748.9CCL2, CCL20, CCL3, IL6, TNF
50chemokine-mediated signaling pathwayGO:00700988.8CCL2, CCL20, CCL3, CCR6, CXCL10

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.1CCL2, CCL20, CCL3, CXCL10
2receptor bindingGO:00051029.0CCL2, CXCL10, IL17RA, IL6, TNFSF4
3cytokine activityGO:00051258.7AIMP1, CCL2, CCL20, IL17A, IL6, TNF

Sources for Stromal Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet