MCID: STR008
MIFTS: 51

Strongyloidiasis malady

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Strongyloidiasis

Aliases & Descriptions for Strongyloidiasis:

Name: Strongyloidiasis 12 50 56 52 3 42 14 69
Disseminated Strongyloidiasis 12 69
Anguilluliasis 56 69
Infection by Strongyloides 12
Threadworm Infection 50
Anguillulosis 56
Enterobiasis 69

Characteristics:

Orphanet epidemiological data:

56
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD10 33 B78 B78.9 B78.7
ICD9CM 35 127.2
MeSH 42 D013322
Orphanet 56 ORPHA76
MESH via Orphanet 43 D013322
ICD10 via Orphanet 34 B78.0 B78.9 B78.1 more
UMLS via Orphanet 70 C0038463
UMLS 69 C0038463

Summaries for Strongyloidiasis

NIH Rare Diseases : 50 strongyloidiasis is a parasitic disease caused by the roundworm strongyloides stercoralis (s. stercoralis). people catch the infection when they come in contact with soil contaminated with the worms. while there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. the infection is treated with anti-worm medications such as ivermectin. strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern united states. last updated: 9/20/2010

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to peptidic growth factors deficiency and natural killer cell leukemia, and has symptoms including fever and pruritus. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

CDC : 3 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Wikipedia : 71 Strongyloidiasis is a human parasitic disease caused by the nematode (roundworm) called Strongyloides... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
id Related Disease Score Top Affiliating Genes
1 peptidic growth factors deficiency 10.3 CCL11 IL5
2 natural killer cell leukemia 10.2 CCL11 IL5
3 latent syphilis 10.2 CCL11 IL5
4 dahlberg borer newcomer syndrome 10.2 IL13 IL5
5 necrotizing gastritis 10.2 CCL11 IL5
6 aortic atherosclerosis 10.2 IL13 IL5
7 renal hypertension 10.2 IL13 IL5
8 hypercementosis 10.2 IL13 IL5
9 spastic paraplegia 3a, autosomal dominant 10.2 IL13 IL5
10 exudative vitreoretinopathy 2, x-linked 10.2 IL13 IL5
11 cerebral primitive neuroectodermal tumor 10.2 CCL11 IL5
12 bone peripheral neuroepithelioma 10.2 IL13 IL5
13 indian plum allergy 10.2 IL13 IL5
14 luminal breast carcinoma 10.2 IL13 IL5
15 lactose intolerance 10.2 IL13 IL5
16 askin's tumor 10.2 IL13 IL5
17 small intestine lymphoma 10.2 CD79A IL5
18 drug psychosis 10.2 CCL11 CD79A
19 smooth muscle tumor 10.2 IL13 IL5
20 prostate small cell carcinoma 10.2 IL13 IL5
21 anterior dislocation of lens 10.2 CCL11 SHE
22 coenurosis 10.2 CD79A IL5
23 subacute glomerulonephritis 10.2 CD79A TGFB1
24 gastroschisis abdominal wall defects, included 10.2 IFNG IL5
25 duodenal somatostatinoma 10.2 IL13 IL5
26 papillary adenocarcinoma 10.2 IL13 TGFB1
27 cerebral lipidosis 10.2 CD79A TGFB1
28 acute pulmonary heart disease 10.2 CD79A IL5
29 malignant renovascular hypertension 10.2 CD79A IFNG
30 albinism 10.2 IFNG IL5
31 cataract, total congenital 10.2 IFNG IL5
32 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.2 IFNG IL5
33 urethral intrinsic sphincter deficiency 10.2 IFNG IL5
34 hemiplegia 10.1 CD79A IL13
35 hemangioma of spleen 10.1 IFNG IL5
36 inclusion conjunctivitis 10.1 CD79A IL5
37 ciliary discoordination, due to random ciliary orientation 10.1 CD79A IFNG
38 clostridium difficile colitis 10.1 CD79A IFNG
39 apricot allergy 10.1 CCL11 CD79A IL5
40 israeli tick typhus 10.1 IFNG IL13
41 osteodysplasty precocious of danks mayne and kozlowski 10.1 CD79A IFNG
42 crustacean allergy 10.1 IFNG IL13
43 multiple mitochondrial dysfunctions syndrome 10.1 IFNG IL5
44 isolated klippel-feil syndrome 10.1 IFNG IL5
45 familial renal papillary carcinoma 10.1 CCL11 CD79A IL5
46 monocytic leukemia 10.1 CCL11 CD79A IL5
47 parkinson disease 11 10.1 CCL11 IFNG
48 metal allergy 10.1 CD79A IL13 IL5
49 venezuelan hemorrhagic fever 10.1 CD79A IFNG
50 actinic keratosis 10.1 CD79A IL13 IL5

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


fever, pruritus

MGI Mouse Phenotypes related to Strongyloidiasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CCL11 CD79A IFNG IL13 IL5 TGFB1
2 immune system MP:0005387 9.43 CCL11 CD79A IFNG IL13 IL5 TGFB1
3 respiratory system MP:0005388 9.02 CCL11 IFNG IL13 IL5 TGFB1

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Vet_approved Phase 3 70288-86-7 6474909 46936176
2
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
3 Anthelmintics Phase 3
4 Anti-Infective Agents Phase 3
5 Antimitotic Agents Phase 3
6 Antiparasitic Agents Phase 3
7 Antiprotozoal Agents Phase 3
8
Formaldehyde Approved, Vet_approved 50-00-0 712
9
Piperazine Approved, Vet_approved 110-85-0 4837
10
Mebendazole Approved, Vet_approved 31431-39-7 4030
11
Diethylcarbamazine Approved, Vet_approved 90-89-1 3052
12 Ether
13 Disinfectants
14 Piperazine citrate

Interventional clinical trials:


id Name Status NCT ID Phase
1 Ivermectin Versus Albendazole for Chronic Strongyloidiasis Unknown status NCT00765024 Phase 3
2 Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Active, not recruiting NCT01570504 Phase 3
3 Management of Soil-transmitted Helminthiasis and Strongyloidiasis Unknown status NCT01308268
4 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
5 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753
6 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
7 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
8 Host Response to Infection and Treatment in Lymphatic Filarial Disease in India Recruiting NCT00342576
9 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

39
Skin, Testes, Lung, T Cells, Kidney, Colon, Liver

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 586)
id Title Authors Year
1
Strongyloidiasis-Related IRIS. ( 27733639 )
2017
2
Strongyloidiasis: Risk and Healthcare Access for Latin American Immigrants Living in the United States. ( 26925367 )
2016
3
Comparative Diagnosis of Strongyloidiasis in Immunocompromised Patients. ( 27296387 )
2016
4
Short epitope-based synthetic peptides for serodiagnosis of human strongyloidiasis. ( 26956434 )
2016
5
Incidence rate and risk factors for giardiasis and strongyloidiasis in returning UK travellers. ( 27432907 )
2016
6
Strongyloidiasis: A Disease of Socioeconomic Disadvantage. ( 27213420 )
2016
7
Poorly controlled asthma and strongyloidiasis in a nonendemic area of the United States. ( 27298264 )
2016
8
Strong-LAMP: A LAMP Assay for Strongyloides spp. Detection in Stool and Urine Samples. Towards the Diagnosis of Human Strongyloidiasis Starting from a Rodent Model. ( 27415764 )
2016
9
Effect of ivermectin on allergy-type manifestations in occult strongyloidiasis. ( 27566864 )
2016
10
StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control. ( 27607192 )
2016
11
Chronic strongyloidiasis - Don't look and you won't find. ( 27051986 )
2016
12
Linear and urticarial rash-like manifestation of acute strongyloidiasis. ( 27613704 )
2016
13
Application of real-time PCR for the diagnosis of strongyloidiasis in North Queensland. ( 27773069 )
2016
14
Pulmonary strongyloidiasis and hyperinfection in a renal transplant patient. ( 27891008 )
2016
15
Gastric Strongyloidiasis: Report of 2 Cases and Brief Review of the Literature. ( 27965275 )
2016
16
Severe strongyloidiasis in AIDS: relative risk obscured by absolute rarity. ( 26825034 )
2016
17
Strongyloidiasis in the immunocompetent: an overlooked infection. ( 27609726 )
2016
18
Strongyloides stercoralis diagnostic polypeptides for human strongyloidiasis and their proteomic analysis. ( 27312043 )
2016
19
Strongyloidiasis Presenting as Epigastric Pain. ( 27924100 )
2016
20
Pulmonary Strongyloidiasis Masquerading as Exacerbation of Chronic Obstructive Pulmonary Disease. ( 27790284 )
2016
21
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. ( 27595647 )
2016
22
Strongyloidiasis in a young French woman raises concern about possible ongoing autochthonous transmission in Spain. ( 26617257 )
2016
23
Protein Loosing Enteropathy Secondary to Strongyloidiasis: Case Report and Review of the Literature. ( 26881152 )
2016
24
A case of disseminated strongyloidiasis in adelaide diagnosed on peritoneal biopsy. ( 27773170 )
2016
25
Donor-Derived Strongyloidiasis Infection in Solid Organ Transplant Recipients: A Review and Pooled Analysis. ( 27742318 )
2016
26
Acute strongyloidiasis in a traveller returning from South East Asia. ( 27192701 )
2016
27
Notes from the Field: Strongyloidiasis at a Long-Term-Care Facility for the Developmentally Disabled - Arizona, 2015. ( 27310213 )
2016
28
Epidemiological Characteristics of Strongyloidiasis in Inhabitants of Indigenous Communities in Borneo Island, Malaysia. ( 27853126 )
2016
29
Advocating for both Environmental and Clinical Approaches to Control Human Strongyloidiasis. ( 27706031 )
2016
30
Strongyloidiasis in Latin American immigrants: a pilot study. ( 27121364 )
2016
31
Potential immunological markers for diagnosis of human strongyloidiasis using heterologous antigens. ( 27894367 )
2016
32
Strongyloidiasis in Ontario: Performance of diagnostic tests over a 14-month period. ( 27794473 )
2016
33
Molecular diagnosis of strongyloidiasis in tropical areas: a comparison of conventional and real-time polymerase chain reaction with parasitological methods. ( 25760451 )
2015
34
IBD or strongyloidiasis? ( 26634698 )
2015
35
Severe strongyloidiasis with negative serology after corticosteroid treatment. ( 25690926 )
2015
36
Strongyloidiasis: an unusual cause of septic shock with pneumonia and enteropathy in western countries. ( 25819827 )
2015
37
Strongyloidiasis: a case for notification in Australia? ( 26021359 )
2015
38
Persistent Strongyloidiasis Complicated by Recurrent Meningitis in an HTLV Seropositive Peruvian Migrant Resettled in Italy. ( 25846292 )
2015
39
Is strongyloidiasis endemic in Spain? ( 25654324 )
2015
40
Membrane fractions from Strongyloides venezuelensis in the immunodiagnosis of human strongyloidiasis. ( 25651330 )
2015
41
IMMUNODIAGNOSIS OF HUMAN STRONGYLOIDIASIS: USE OF SIX DIFFERENT ANTIGENIC FRACTIONS FROM Strongyloides venezuelensis PARASITIC FEMALES. ( 26603231 )
2015
42
Bacteroides-associated pylephlebitis in a patient with strongyloidiasis. ( 25510718 )
2015
43
Immunofluorescence assay for diagnosis of strongyloidiasis in immunocompromised patients. ( 25832456 )
2015
44
Cervical strongyloidiasis in an immunocompetent patient: A clinical surprise. ( 26275275 )
2015
45
Strongyloidiasis in immigrants and refugees in Canada. ( 26149698 )
2015
46
A COMPLICATED CASE OF STRONGYLOIDIASIS PRESENTING WITH INTESTINAL LYMPHADENOPATHY OBSTRUCTION: MOLECULAR IDENTIFICATION. ( 26513898 )
2015
47
Pulmonary Hemorrhage Secondary to Disseminated Strongyloidiasis in a Patient with Systemic Lupus Erythematosus. ( 26101672 )
2015
48
Clinical conditions associated with intestinal strongyloidiasis in Rio de Janeiro, Brazil. ( 26108011 )
2015
49
Development of Ss-NIE-1 Recombinant Antigen Based Assays for Immunodiagnosis of Strongyloidiasis. ( 25860665 )
2015
50
Disseminated gastrointestinal strongyloidiasis. ( 26481977 )
2015

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CCL11 IFNG IL13 IL5 TGFB1
2
Show member pathways
13.08 CCL11 IFNG IL13 IL5 TGFB1
3
Show member pathways
12.57 CCL11 IFNG IL13 IL5 TGFB1
4
Show member pathways
12.35 IFNG IL13 IL5 TGFB1
5
Show member pathways
12.18 IFNG IL5 TGFB1
6
Show member pathways
12.09 CCL11 IFNG IL13 IL5
7
Show member pathways
11.97 IFNG IL13 IL5
8
Show member pathways
11.93 IFNG IL13 IL5
9 11.78 CD79A IFNG IL5
10 11.76 CCL11 IL13 TGFB1
11 11.58 IFNG IL13 IL5
12 11.56 IFNG IL13 IL5
13 11.3 IFNG TGFB1
14 11.29 IFNG TGFB1
15 11.26 CCL11 IL13 IL5 TGFB1
16
Show member pathways
11.2 IFNG TGFB1
17 11.1 IFNG IL5
18 11.09 IFNG IL13 IL5
19 10.99 IFNG IL13 TGFB1
20 10.98 CCL11 IL13 IL5
21 10.93 CCL11 IFNG IL13 IL5
22 10.91 IFNG IL13 IL5
23 10.61 IL13 IL5 TGFB1
24 10.4 IFNG IL13 IL5 TGFB1

GO Terms for Strongyloidiasis

Cellular components related to Strongyloidiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD79A IFNG IL13
2 extracellular space GO:0005615 9.02 CCL11 IFNG IL13 IL5 TGFB1

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extrinsic apoptotic signaling pathway GO:0097191 9.46 IFNG TGFB1
2 immune response GO:0006955 9.46 CCL11 IFNG IL13 IL5
3 positive regulation of protein secretion GO:0050714 9.43 IL13 TGFB1
4 positive regulation of B cell proliferation GO:0030890 9.4 IL13 IL5
5 response to radiation GO:0009314 9.37 CCL11 TGFB1
6 protein import into nucleus, translocation GO:0000060 9.32 IFNG TGFB1
7 positive regulation of protein complex assembly GO:0031334 9.26 IFNG TGFB1
8 negative regulation of interleukin-17 production GO:0032700 8.96 IFNG TGFB1
9 inflammatory response GO:0006954 8.92 CCL11 IL13 IL5 TGFB1

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 IFNG IL13 IL5 TGFB1

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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