MCID: STR008
MIFTS: 54

Strongyloidiasis

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Strongyloidiasis

MalaCards integrated aliases for Strongyloidiasis:

Name: Strongyloidiasis 12 72 49 55 51 3 41 14 69
Disseminated Strongyloidiasis 12 69
Anguilluliasis 55 69
Infection by Strongyloides 12
Threadworm Infection 49
Anguillulosis 55
Enterobiasis 69

Characteristics:

Orphanet epidemiological data:

55
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD10 32 B78 B78.9 B78.7
ICD9CM 34 127.2
MeSH 41 D013322
Orphanet 55 ORPHA76
MESH via Orphanet 42 D013322
UMLS via Orphanet 70 C0038463 C0085810
ICD10 via Orphanet 33 B78.0 B78.1 B78.7 more

Summaries for Strongyloidiasis

NIH Rare Diseases : 49 Strongyloidiasis is a parasitic disease caused by the roundworm Strongyloides stercoralis (S. stercoralis). People catch the infection when they come in contact with soil contaminated with the worms. While there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. The infection is treated with anti-worm medications such as ivermectin. Strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern United States. Last updated: 9/20/2010

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to giardiasis and enterobiasis, and has symptoms including pruritus and fever. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Albendazole and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related phenotypes are hematopoietic system and respiratory system

CDC : 3 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

Wikipedia : 72 Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis,... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 giardiasis 30.0 CD79A TGFB1
2 enterobiasis 29.9 IL13 IL5
3 cryptosporidiosis 29.8 CCL11 CD79A
4 paragonimiasis 29.8 IL13 IL5
5 intestinal schistosomiasis 29.8 IL13 IL5
6 pneumonia 29.6 CCL11 IL13 IL5
7 bronchitis 29.5 CCL11 CD79A IL5
8 schistosomiasis 29.4 CD79A IFNG IL13 IL5
9 parasitic helminthiasis infectious disease 29.4 CD79A IL13 IL5
10 filariasis 29.4 IFNG IL5
11 reactive arthritis 29.3 CD79A IFNG
12 folliculitis 29.3 CCL11 IFNG IL5
13 dermatitis 28.7 CCL11 IFNG IL13 IL5
14 asthma 28.6 CCL11 CD79A IFNG IL13 IL5
15 inflammatory bowel disease 27.8 CCL11 CD79A IFNG IL13 IL5 TGFB1
16 cow milk allergy 10.4 CD79A IL5
17 pemphigoid gestationis 10.4 CCL11 IL5
18 chronic meningitis 10.4 CCL11 IL5
19 eosinophilic gastroenteritis 10.4 CCL11 IL5
20 chronic eosinophilic pneumonia 10.4 CCL11 IL5
21 anterior scleritis 10.4 CD79A IL5
22 primary amebic meningoencephalitis 10.4 CD79A IL5
23 kimura disease 10.3 CCL11 IL5
24 cytokine deficiency 10.3 IL13 IL5
25 milk allergy 10.3 CD79A IL5
26 rapidly progressive glomerulonephritis 10.3 CD79A TGFB1
27 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
28 bullous skin disease 10.3 CD79A IL5
29 respiratory syncytial virus infectious disease 10.3 IL13 IL5
30 inflammatory bowel disease 4 10.3 IL13 IL5
31 apple allergy 10.3 IL13 IL5
32 nut allergy 10.3 IL13 IL5
33 latex allergy 10.3 IL13 IL5
34 night blindness, congenital stationary, type 1a 10.3 IL13 IL5
35 chronic tic disorder 10.3 IL13 IL5
36 radiation cystitis 10.3 IL13 IL5
37 blepharoconjunctivitis 10.3 CCL11 SHE
38 gingival disease 10.2 CD79A TGFB1
39 eosinophilic fasciitis 10.2 IFNG IL5
40 blepharitis 10.2 CCL11 SHE
41 atopic keratoconjunctivitis 10.2 IFNG IL5
42 neuroschistosomiasis 10.2 CD79A IFNG
43 ascaris lumbricoides infection 10.2 IFNG IL5
44 sporotrichosis 10.2 CD79A IFNG
45 esophageal disease 10.2 IL13 IL5
46 lipoid nephrosis 10.2 CD79A IL13
47 chronic graft versus host disease 10.2 CD79A IFNG
48 dermatitis herpetiformis 10.2 CCL11 CD79A
49 ocular cicatricial pemphigoid 10.2 CD79A TGFB1
50 multicentric castleman disease 10.2 IFNG IL5

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


pruritus, fever

MGI Mouse Phenotypes related to Strongyloidiasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CCL11 CD79A IFNG IL13 IL5 TGFB1
2 respiratory system MP:0005388 9.02 CCL11 IFNG IL13 IL5 TGFB1

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2
Ivermectin Approved, Investigational, Vet_approved Phase 3 70288-86-7 46936176 6474909
3 Anthelmintics Phase 3
4 Anti-Infective Agents Phase 3
5 Antimitotic Agents Phase 3
6 Antiparasitic Agents Phase 3
7 Antiprotozoal Agents Phase 3
8
Mebendazole Approved, Vet_approved 31431-39-7 4030
9
Formaldehyde Approved, Vet_approved 50-00-0 712
10
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
11 Disinfectants
12 Ether

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ivermectin Versus Albendazole for Chronic Strongyloidiasis Completed NCT00765024 Phase 3 Ivermectin;ivermectin;Albendazole
2 Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Active, not recruiting NCT01570504 Phase 3 Ivermectin
3 Management of Soil-transmitted Helminthiasis and Strongyloidiasis Unknown status NCT01308268 Ivermectin + Albendazole
4 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
5 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
6 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
7 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
8 Host Response to Infection and Treatment in Lymphatic Filarial Disease in India Recruiting NCT00342576
9 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

38
Skin, Testes, Lung, T Cells, Kidney, Colon, Liver

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 617)
# Title Authors Year
1
Chronic strongyloidiasis with recurrent asthma exacerbations and steroid-associated 'hives'. ( 29348277 )
2018
2
Schistosomiasis and Strongyloidiasis Recommendations for Solid-Organ Transplant Recipients and Donors. ( 29381575 )
2018
3
Image Gallery: Periumbilical purpura: aA dermatological clue for disseminated strongyloidiasis. ( 29441550 )
2018
4
Identification and Preliminary Evaluation of a Novel Recombinant Protein for Serodiagnosis of Strongyloidiasis. ( 29436335 )
2018
5
Severe Strongyloidiasis in Solid Organ Transplant Recipients: Should We Preventively Treat the Recipient, the Donor, or Both? ( 29363441 )
2018
6
Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up After Ivermectin Treatment. ( 29360939 )
2018
7
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells. ( 28676845 )
2017
8
A case of adenocarcinoma developed in the small intestine with chronic strongyloidiasis. ( 28988405 )
2017
9
Seroepidemiological trend of strongyloidiasis in the Bolivian Chaco (1987-2013) in the absence of disease-specific control measures. ( 28929562 )
2017
10
Strongyloidiasis ( 28613526 )
2017
11
Different but overlapping populations of Strongyloides stercoralis in dogs and humans-Dogs as a possible source for zoonotic strongyloidiasis. ( 28793306 )
2017
12
Surveillance of strongyloidiasis in Spanish in-patients (1998-2014). ( 29284005 )
2017
13
An eleven-year retrospective hospital-based study of epidemiological data regarding human strongyloidiasis in northeast Thailand. ( 28923008 )
2017
14
Parasitological versus molecular diagnosis of strongyloidiasis in serial stool samples: how many? ( 28112060 )
2017
15
Immune complex detection in saliva samples: an innovative proposal for the diagnosis of human strongyloidiasis. ( 29239289 )
2017
16
Avidity as a criterion for diagnosis of human strongyloidiasis increases specificity of IgG ELISA. ( 28969935 )
2017
17
Mass drug administration for the prevention human strongyloidiasis should consider concomitant treatment of dogs. ( 28837662 )
2017
18
Occurrence of strongyloidiasis in privately owned and sheltered dogs: clinical presentation and treatment outcome. ( 28728589 )
2017
19
Twenty-five Years of Chronic Strongyloidiasis in an Immigrant. ( 28469498 )
2017
20
Strongyloidiasis-Related IRIS. ( 27733639 )
2017
21
Screening of immunocompromised patients at risk of strongyloidiasis in western Turkey using ELISA and real-time PCR. ( 28618740 )
2017
22
The severely under-recognized public health risk of strongyloidiasis in North American cities-A One Health approach. ( 28670749 )
2017
23
Strongyloides Stercoralis (Strongyloidiasis) ( 28613795 )
2017
24
A Case of Strongyloidiasis: An Immigrant Healthcare Worker Presenting with Fatigue and Weight Loss. ( 28744381 )
2017
25
Purpuric lesion in an immunocompromised patient: a presentation of disseminated strongyloidiasis. ( 28261873 )
2017
26
Intestinal strongyloidiasis: radiological findings that support the diagnosis. ( 28428660 )
2017
27
Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases. ( 28464844 )
2017
28
Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research. ( 28210503 )
2017
29
Acute strongyloidiasis in a child recently returned from vacation in Cuba. ( 29158455 )
2017
30
Disseminated strongyloidiasis and concomitant Aspergillus infection with central nervous system involvement. ( 28139968 )
2017
31
Evidence-Based Guidelines for Screening and Management of Strongyloidiasis in Non-Endemic Countries. ( 28749768 )
2017
32
Application of real-time PCR for the diagnosis of strongyloidiasis in North Queensland. ( 27773069 )
2016
33
Strongyloidiasis: Risk and Healthcare Access for Latin American Immigrants Living in the United States. ( 26925367 )
2016
34
StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control. ( 27607192 )
2016
35
Advocating for both Environmental and Clinical Approaches to Control Human Strongyloidiasis. ( 27706031 )
2016
36
Strongyloidiasis Presenting as Epigastric Pain. ( 27924100 )
2016
37
Chronic strongyloidiasis - Don't look and you won't find. ( 27051986 )
2016
38
Acute strongyloidiasis in a traveller returning from South East Asia. ( 27192701 )
2016
39
A case of disseminated strongyloidiasis in adelaide diagnosed on peritoneal biopsy. ( 27773170 )
2016
40
Strongyloidiasis in a young French woman raises concern about possible ongoing autochthonous transmission in Spain. ( 26617257 )
2016
41
Donor-Derived Strongyloidiasis Infection in Solid Organ Transplant Recipients: A Review and Pooled Analysis. ( 27742318 )
2016
42
Notes from the Field: Strongyloidiasis at a Long-Term-Care Facility for the Developmentally Disabled - Arizona, 2015. ( 27310213 )
2016
43
Strongyloides stercoralis diagnostic polypeptides for human strongyloidiasis and their proteomic analysis. ( 27312043 )
2016
44
Linear and urticarial rash-like manifestation of acute strongyloidiasis. ( 27613704 )
2016
45
Protein Loosing Enteropathy Secondary to Strongyloidiasis: Case Report and Review of the Literature. ( 26881152 )
2016
46
Severe strongyloidiasis in AIDS: relative risk obscured by absolute rarity. ( 26825034 )
2016
47
Disseminated Strongyloidiasis in an Immunodeficient Patient (Pemphigus Vulgaris) Due to Corticosteroid Therapy: A Case Report. ( 28127349 )
2016
48
Strongyloidiasis in the immunocompetent: an overlooked infection. ( 27609726 )
2016
49
Strong-LAMP: A LAMP Assay for Strongyloides spp. Detection in Stool and Urine Samples. Towards the Diagnosis of Human Strongyloidiasis Starting from a Rodent Model. ( 27415764 )
2016
50
Strongyloidiasis in Latin American immigrants: a pilot study. ( 27121364 )
2016

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CCL11 IFNG IL13 IL5 TGFB1
2
Show member pathways
13.08 CCL11 IFNG IL13 IL5 TGFB1
3 12.58 IFNG IL13 IL5 TGFB1
4
Show member pathways
12.57 CCL11 IFNG IL13 IL5 TGFB1
5
Show member pathways
12.35 IFNG IL13 IL5 TGFB1
6
Show member pathways
12.34 CD79A IL13 IL5
7
Show member pathways
12.2 IFNG IL5 TGFB1
8
Show member pathways
12.14 IFNG IL13 IL5
9
Show member pathways
12.09 CCL11 IFNG IL13 IL5
10
Show member pathways
11.93 IFNG IL13 IL5
11 11.78 CD79A IFNG IL5
12 11.76 CCL11 IL13 TGFB1
13 11.58 IFNG IL13 IL5
14 11.56 IFNG IL13 IL5
15 11.32 IFNG TGFB1
16 11.3 IFNG TGFB1
17 11.26 CCL11 IL13 IL5 TGFB1
18
Show member pathways
11.16 IFNG TGFB1
19 11.12 IFNG IL5
20 11.09 IFNG IL13 IL5
21 11 CCL11 IL13 IL5
22 10.99 IFNG IL13 TGFB1
23 10.92 CCL11 IFNG IL13 IL5
24 10.91 IFNG IL13 IL5
25 10.77 CCL11 IL13 IL5 TGFB1
26 10.51 IL13 IL5 TGFB1
27 10.4 IFNG IL13 IL5 TGFB1

GO Terms for Strongyloidiasis

Cellular components related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCL11 IFNG IL13 IL5 TGFB1

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 CCL11 IFNG IL13 IL5
2 extrinsic apoptotic signaling pathway GO:0097191 9.49 IFNG TGFB1
3 positive regulation of protein secretion GO:0050714 9.48 IL13 TGFB1
4 positive regulation of B cell proliferation GO:0030890 9.46 IL13 IL5
5 response to radiation GO:0009314 9.43 CCL11 TGFB1
6 protein import into nucleus, translocation GO:0000060 9.4 IFNG TGFB1
7 positive regulation of protein complex assembly GO:0031334 9.37 IFNG TGFB1
8 regulation of regulatory T cell differentiation GO:0045589 9.26 IFNG TGFB1
9 inflammatory response GO:0006954 9.26 CCL11 IL13 IL5 TGFB1
10 negative regulation of interleukin-17 production GO:0032700 9.16 IFNG TGFB1
11 regulation of receptor activity GO:0010469 9.02 CCL11 IFNG IL13 IL5 TGFB1

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 IFNG IL13 IL5 TGFB1

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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