MCID: STR008
MIFTS: 58

Strongyloidiasis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories

Summaries for Strongyloidiasis

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NIH Rare Diseases:41 Strongyloidiasis is a parasitic disease caused by the roundworm strongyloides stercoralis (s. stercoralis). people catch the infection when they come in contact with soil contaminated with the worms. while there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. the infection is treated with anti-worm medications such as ivermectin. strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern united states. last updated: 9/20/2010

MalaCards based summary: Strongyloidiasis, also known as disseminated strongyloidiasis, is related to filariasis and folliculitis. An important gene associated with Strongyloidiasis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Inflammatory Response Pathway and Cytokine Network. The drugs ivermectin and mebendazole and the compounds clarithromycin and pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:9 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode strongyloides stercoralis.

CDC:3 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Wikipedia:63 Strongyloidiasis is a human parasitic disease caused by the nematode (roundworm) called Strongyloides... more...

Aliases & Classifications for Strongyloidiasis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 3CDC, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 61UMLS via Orphanet, 34MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Strongyloidiasis, Aliases & Descriptions:

Name: Strongyloidiasis 9 41 11 43 47 3 60
Disseminated Strongyloidiasis 9 60
Anguilluliasis 47 60
Infection by Strongyloides 9
 
Threadworm Infection 41
Anguillulosis 47
Enterobiasis 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

47
strongyloidiasis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:10955
MeSH33 D013322
ICD9CM27 127.2
Orphanet47 76
UMLS via Orphanet61 C0038463
MESH via Orphanet34 D013322
ICD10 via Orphanet26 B78.0, B78.1, B78.7 B78.9, more
ICD1025 B78, B78.7, B78.9

Related Diseases for Strongyloidiasis

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Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1filariasis30.9IGHE, IL5
2folliculitis30.7CCL11
3giardiasis30.6CD79A
4amebiasis30.6CD79A
5schistosomiasis30.5IGHE, IFNG, IL5, CD79A
6cryptosporidiosis30.5CD79A
7paragonimiasis30.5IGHE, IL5
8asthma30.5IGHE, IL5
9nephrotic syndrome30.5CD79A, ALB, CCL11
10eosinophilia30.4IGHE, CCL11, IFNG, IL5, CD79A
11meningitis30.4ALB, CD79A
12protein-losing enteropathy30.3ALB
13bronchitis30.3IL5, CCL11, IGHE
14candidiasis30.1CD79A, IFNG
15pneumonia30.0TGFB1, CCL11, IL5, CD79A
16glomerulonephritis30.0TGFB1, ALB, CD79A
17ulcerative colitis29.9CCL11, IFNG, CD79A
18dermatitis29.7IGHE, CCL11, IFNG, IL5, CD79A
19lung cancer29.7TP53, TGFB1, LGALS3BP
20leukemia29.6IFNG, CCL11, TGFB1, TP53, CD79A, CD7
21tuberculosis29.6CD79A, ALB, IFNG
22burkitt lymphoma29.3CD7, CD79A, ALB, CCL11, TP53
23eosinophilic fasciitis10.6IL5
24eosinophilia-myalgia syndrome10.5IL5
25eczema herpeticum10.5IGHE
26gastroenteritis10.5CD79A
27exanthem10.5CD79A
28common cold10.5CCL11
29henoch-schoenlein purpura10.5CD79A
30poems syndrome10.5CD79A
31pyelonephritis10.4CD79A
32egg allergy10.4IGHE, IL5
33acute poststreptococcal glomerulonephritis10.4CD79A
34parasitic helminthiasis infectious disease10.4IGHE, IL5
35intrinsic asthma10.4IGHE, IL5
36epidermolysis bullosa acquisita10.4CD79A
37allergic bronchopulmonary aspergillosis10.4IL5, IGHE
38kimura disease10.4IGHE, IL5
39contact dermatitis10.4IGHE, IL5
40allergic rhinitis10.4IGHE, IL5
41chronic eosinophilic pneumonia10.4CCL11, IL5
42thyroiditis10.4CD79A
43giant papillary conjunctivitis10.4CCL11, IL5
44omenn syndrome10.4IL5, IGHE
45keratoconjunctivitis10.4CCL11, IL5
46esophagitis, eosinophilic, 110.4CCL11, IL5
47mastocytosis10.4IGHE, IL5
48conjunctivitis10.4CD79A, IGHE
49duodenitis10.4
50angioedema10.4IL5, IGHE

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to strongyloidiasis

Symptoms for Strongyloidiasis

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Drugs & Therapeutics for Strongyloidiasis

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Drug clinical trials:

Search ClinicalTrials for Strongyloidiasis

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Strongyloidiasis

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Anatomical Context for Strongyloidiasis

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MalaCards organs/tissues related to Strongyloidiasis:

31
Skin, Lung, T cells, Testes, Kidney, Colon, Liver, Heart, Breast

Animal Models for Strongyloidiasis or affiliated genes

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MGI Mouse Phenotypes related to Strongyloidiasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7TP53, TGFB1, IFNG, IL5, ALB
2MP:00053708.7ALB, IL5, IFNG, TGFB1, TP53
3MP:00028738.6CD79A, ALB, IFNG, CCL11, TP53
4MP:00053888.6TP53, TGFB1, CCL11, IFNG, IL5
5MP:00053678.6TP53, TGFB1, IFNG, ALB, CD79A
6MP:00053818.3TP53, TGFB1, IFNG, IL5, ALB
7MP:00053977.4IGHE, TP53, TGFB1, CCL11, IFNG, IL5
8MP:00053767.4IGHE, TP53, TGFB1, LGALS3BP, IFNG, IL5
9MP:00053876.9CD7, IGHE, TP53, TGFB1, LGALS3BP, CCL11

Publications for Strongyloidiasis

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Articles related to Strongyloidiasis:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Update on immunologic and molecular diagnosis of human strongyloidiasis. (24686097)
2014
2
Strongyloidiasis hyperinfection in a patient with a history of systemic lupus erythematosus. (25092815)
2014
3
Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. (23592987)
2013
4
Strongyloidiasis presenting as larva currens 38 years after presumed exposure. (23149200)
2012
5
Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin. (22975175)
2012
6
A series on intestinal strongyloidiasis in immunocompetent and immunocompromised hosts. (23025061)
2012
7
IgG avidity in differential serodiagnosis of human strongyloidiasis active infection. (21699917)
2011
8
Uncomplicated strongyloidiasis in a liver transplant recipient on steroid-free immunosuppression. (20487417)
2010
9
Pulmonary strongyloidiasis. (20329418)
2009
10
Strongyloidiasis: endoscopic diagnosis. (18955162)
2009
11
Identification of a 26-kDa protein fraction as an important antigen for application in the immunodiagnosis of strongyloidiasis. (17569087)
2007
12
IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen. (17610082)
2007
13
Evaluation of an indirect immunofluorescence assay for strongyloidiasis as a tool for diagnosis and follow-up. (17135451)
2007
14
Disseminated strongyloidiasis and cytomegalovirus infection in a patient with anaplastic large cell lymphoma. (17641892)
2007
15
Strongyloidiasis stercoralis: is it a health problem in Saudi Arabia? (17366869)
2006
16
Intestinal strongyloidiasis and common variable immunodeficiency syndrome. (15876606)
2005
17
Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease? (16410894)
2005
18
Successful use of parenteral ivermectin in an immunosuppressed patient with disseminated strongyloidiasis and septic shock. (16041520)
2005
19
Severe gastrointestinal strongyloidiasis. (16082494)
2005
20
Successful ivermectin treatment of hepatic strongyloidiasis presenting with severe eosinophilia. (15455986)
2004
21
Pulmonary strongyloidiasis presenting as chronic bronchitis leading to interlobular septal fibrosis and cured by treatment. (14708557)
2003
22
Strongyloides venezuelensis alkaline extract for the diagnosis of human strongyloidiasis by enzyme-linked immunosorbent assay. (14595467)
2003
23
Strongyloidiasis and natural killer cell lymphocytosis. (10809888)
2000
24
Pulmonary strongyloidiasis--case report of 2 cases. (10969524)
2000
25
High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis. (11042682)
2000
26
Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies). (10096585)
1999
27
Strongyloidiasis, angio-oedema and natural killer cell lymphocytosis. (10354098)
1999
28
Parasite-specific serum IgG following successful treatment of endemic strongyloidiasis using ivermectin. (9015524)
1996
29
Fulminant, systemic strongyloidiasis in AIDS. (8758145)
1996
30
Expression of CD23, CD32, Mac-1 and other adhesion molecules in eosinophils in strongyloidiasis and HTLV-I-positive patients. (8906113)
1996
31
Interrelation of strongyloidiasis and tuberculosis. (8063205)
1994
32
Strongyloides stercoralis: the first rodent model for uncomplicated and hyperinfective strongyloidiasis, the Mongolian gerbil (Meriones unguiculatus). (8245532)
1993
33
Direct and indirect diagnosis of strongyloidiasis. (1578156)
1992
34
Fatal adult respiratory distress syndrome following successful treatment of pulmonary strongyloidiasis. (1995245)
1991
35
Aphthoid ulceration of the colon in strongyloidiasis. (2028960)
1991
36
Gelatin particle indirect agglutination test for mass examination for strongyloidiasis. (1755062)
1991
37
Strongyloidiasis associated with human T-cell lymphotropic virus type I infection in a nonendemic area. (2588581)
1989
38
Diagnosis of pulmonary strongyloidiasis by bronchoalveolar lavage. (3409752)
1988
39
Endemic institutional strongyloidiasis in British Columbia. (3607675)
1987
40
Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. (2886441)
1987
41
Seroepidemiology of strongyloidiasis in a Thai village. (3429125)
1987
42
Concentrations of thiabendazole and parasite-specific IgG antibodies in the cerebrospinal fluid of a patient with disseminated strongyloidiasis. (3611836)
1987
43
Indigenous strongyloidiasis in Nottingham. (3109595)
1987
44
Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis. (3711300)
1986
45
Risk factors for strongyloidiasis. A case-control study. (6696569)
1984
46
Cambendazole in the treatment of human strongyloidiasis. (6625071)
1983
47
Immunological features in different clinical forms of strongyloidiasis. (6623593)
1983
48
Pulmonary strongyloidiasis. (7063915)
1982
49
Strongyloidiasis and chronic urticaria. (7111108)
1982
50
Transmission of strongyloidiasis by kidney transplant? Disseminated strongyloidiasis in both recipients of kidney allografts from a single cadaver donor. (7026811)
1981

Variations for Strongyloidiasis

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Expression for genes affiliated with Strongyloidiasis

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Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for genes affiliated with Strongyloidiasis

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Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL5
29.9IL5, IFNG
39.9IL5, IFNG
49.8IL5, TGFB1
5
Show member pathways
9.8IFNG, TGFB1
69.8IFNG, TGFB1
79.5IL5, IFNG, TGFB1
8
Show member pathways
9.5IL5, IFNG, TGFB1
99.4IL5, IFNG, TP53
109.4IL5, CCL11, IGHE
11
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.4IGHE, IL5, CD79A
12
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.3IFNG, TGFB1, TP53
139.3IFNG, TGFB1, TP53
149.3IFNG, TGFB1, TP53
159.3TP53, TGFB1, IFNG
16
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.2IGHE, TP53, CCL11
17
Show member pathways
9.2IL5, IFNG, CCL11, TGFB1
18
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.2TGFB1, IFNG, IL5, CD79A
19
Show member pathways
9.1IL5, CCL11, TGFB1, TP53
20
Show member pathways
8.7TP53, TGFB1, CCL11, IFNG, IL5
21
Show member pathways
8.7TP53, TGFB1, CCL11, IFNG, IL5

Compounds for genes affiliated with Strongyloidiasis

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Compounds related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1clarithromycin43 1210.9CCL11, CD79A, IL5
2pirfenidone43 5910.8TGFB1, IFNG, IL5
3gamma globulin439.8CD79A, ALB, IFNG
4con a439.8CD79A, IL5, IFNG
5cetirizine43 28 24 1212.8IGHE, CCL11, IL5
6l-tryptophan49 28 43 24 1213.8ALB, IFNG, IL5
7ketotifen43 1210.7IL5, CCL11, IGHE
8rolipram43 59 2811.7CCL11, IFNG, IL5
9praziquantel43 1210.7IGHE, CD79A, IL5
10ramipril43 1210.7TGFB1, CD79A, ALB
11gm-csf43 2810.7IL5, IFNG, TGFB1
12penicillin439.7IL5, CD79A, IGHE
13montelukast43 49 28 1212.7IGHE, IL5, CCL11
14hhpa439.7ALB, IGHE
15poly(i-c)439.6CCL11, IFNG, IL5
16sulfamethoxazole49 43 1211.6IL5, IGHE, ALB
17glutaraldehyde439.6TGFB1, CD79A, ALB
18pgd2439.5IGHE, CCL11, IL5
19unicap439.5IL5, CCL11, CD79A, IGHE
20sodium cromoglycate439.5CD79A, IL5, CCL11, IGHE
21methylcellulose439.5IL5, IFNG, TGFB1
22salbutamol43 49 28 24 1213.5CD79A, IGHE, CCL11, IL5
23budesonide43 49 1211.5IFNG, IGHE, CCL11, IL5
24fluticasone propionate43 49 59 1212.5IL5, IFNG, IGHE, CCL11
25tarc439.5IGHE, IL5, IFNG, CCL11
26mycophenolate mofetil43 49 1211.4ALB, CD79A, IFNG
27hyaluronic acid43 2410.4TGFB1, CCL11, ALB, CD79A
28il 10439.2IL5, TGFB1, IFNG
29pge2439.2CCL11, CD79A, IL5, TGFB1, IFNG
30allergens439.2IFNG, CCL11, IGHE, IL5, CD79A
31methacholine43 49 1211.1CD79A, IGHE, TGFB1, CCL11, IL5
32sb 20358043 5910.1IL5, IFNG, CCL11, TGFB1, TP53
33butyrate439.1IL5, IFNG, CCL11, TGFB1, TP53
34rantes439.1IFNG, IL5, CCL11, TGFB1
35ivig439.0IL5, CD79A, IFNG, IGHE, ALB
36thymidine43 2410.0CCL11, TGFB1, TP53, IL5, IFNG
37thyroxine43 2410.0IGHE, IL5, CD79A, ALB, TGFB1
38methotrexate49 43 1211.0CD79A, ALB, IL5, IGHE, TGFB1
39vitamin d439.0IL5, IGHE, ALB, TGFB1, CD79A
40heparin43 28 24 1211.9CD79A, ALB, IL5, CCL11, IGHE
41tacrolimus43 49 1210.9TGFB1, ALB, CCL11, CD79A, IFNG, IL5
42actinomycin d438.8TP53, IGHE, TGFB1, CCL11, IFNG
43cyclosporin a43 28 5910.8IL5, CD79A, IFNG, IGHE, CCL11, TGFB1
44prednisolone43 28 1210.8ALB, CD79A, IL5, IFNG, CCL11, IGHE
45dexamethasone43 49 28 1211.7IL5, CD79A, IFNG, TGFB1, CCL11, IGHE
46cycloheximide438.7IFNG, IL5, TGFB1, TP53, IGHE
47indomethacin43 28 59 1211.4CD79A, ALB, IL5, IFNG, CCL11, TGFB1
48histamine43 28 2410.4IGHE, IFNG, CD79A, TGFB1, ALB, IL5
49vegf438.3CCL11, IL5, CD79A, IFNG, TGFB1, TP53
50retinoic acid43 249.3TP53, TGFB1, CCL11, IFNG, IL5, CD79A

GO Terms for genes affiliated with Strongyloidiasis

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Cellular components related to Strongyloidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.2ALB, LGALS3BP, TGFB1
2extracellular spaceGO:00056158.2ALB, IL5, IFNG, CCL11, LGALS3BP, TGFB1
3extracellular regionGO:00055768.0IGHE, TGFB1, CCL11, IFNG, IL5, ALB

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuroblast proliferationGO:00074069.8TGFB1, TP53
2positive regulation of histone deacetylationGO:00310659.8TGFB1, TP53
3positive regulation of cell cycle arrestGO:00711589.7TGFB1, TP53
4response to radiationGO:00093149.7TGFB1, CCL11
5negative regulation of DNA replicationGO:00081569.6TGFB1, TP53
6inflammatory responseGO:00069549.5IL5, CCL11, TGFB1
7protein import into nucleus, translocationGO:00000609.5IFNG, TGFB1, TP53
8extrinsic apoptotic signaling pathwayGO:00971919.5IFNG, TGFB1
9cell cycle arrestGO:00070509.4TP53, TGFB1, IFNG
10immune responseGO:00069559.0IGHE, CCL11, IL5, CD7

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.2ALB, TGFB1, TP53

Products for genes affiliated with Strongyloidiasis

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  • Antibodies
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Sources for Strongyloidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet