MCID: STR008
MIFTS: 64

Strongyloidiasis malady

Rare diseases, Infectious diseases categories

Summaries for Strongyloidiasis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 4CDC, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Strongyloidiasis is a parasitic disease caused by the roundworm strongyloides stercoralis (s. stercoralis). people catch the infection when they come in contact with soil contaminated with the worms. while there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. the infection is treated with anti-worm medications such as ivermectin. strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern united states. last updated: 9/20/2010

MalaCards: Strongyloidiasis, also known as disseminated strongyloidiasis, is related to eosinophilia and nephrotic syndrome. An important gene associated with Strongyloidiasis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Inflammatory Response Pathway and Cytokine Network. The drugs ivermectin and thiabendazole and the compounds clarithromycin and pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:9 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode strongyloides stercoralis.

CDC:4 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Wikipedia:66 Strongyloidiasis is a human parasitic disease caused by the nematode (roundworm) Strongyloides... more...

Aliases & Classifications for Strongyloidiasis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 27ICD10 via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
strongyloidiasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

strongyloidiasis 9 44 11 46 50 63
disseminated strongyloidiasis 9 63
anguilluliasis 50 63
strongyloidiasis, unspecified 9
infection by strongyloides 9
threadworm infection 44
anguillulosis 50


External Ids:

Disease Ontology9 DOID:10955
MeSH36 D013322
ICD9CM28 127.2
MESH via Orphanet37 D013322
SNOMED-CT via Orphanet60 1214006
UMLS via Orphanet64 C0038463
ICD10 via Orphanet27 B78.0, B78.1, B78.7 B78.9, more
ICD1026 B78, B78.7, B78.9

Related Diseases for Strongyloidiasis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia30.6IL5, CD79A, IFNG, CCL11, IGHE
2nephrotic syndrome30.5CCL11, CD79A, ALB
3schistosomiasis30.5CD79A, IL5, IFNG, IGHE
4meningitis30.4CD79A, ALB
5filariasis30.4IGHE, IL5
6leukemia30.2TP53, CD79A, CD7, IFNG, CCL11, TGFB1
7folliculitis30.0CCL11
8glomerulonephritis30.0TGFB1, ALB, CD79A
9amebiasis30.0CD79A
10cryptosporidiosis30.0CD79A
11helminthiasis30.0IL5, IGHE
12asthma30.0IGHE, IL5
13bronchitis30.0IGHE, IL5, CCL11
14candidiasis29.9IFNG, CD79A
15ulcerative colitis29.9CCL11, IFNG, CD79A
16pneumonia29.8TGFB1, CCL11, CD79A, IL5
17dermatitis29.8CD79A, IL5, IFNG, IGHE, CCL11
18lung cancer29.8TGFB1, TP53, LGALS3BP
19tuberculosis29.8IFNG, CD79A, ALB
20duodenitis10.4
21acquired immunodeficiency syndrome10.3
22purpura10.3
23paralytic ileus10.2
24adult t-cell leukemia10.2
25t-cell leukemia10.2
26ileus10.2
27common variable immunodeficiency10.1
28isosporiasis10.1
29eosinophilic fasciitis10.1IL5
30eosinophilia-myalgia syndrome10.1IL5
31eczema herpeticum10.1IGHE
32gastroenteritis10.1CD79A
33exanthem10.1CD79A
34common cold10.1CCL11
35henoch-schoenlein purpura10.1CD79A
36giardiasis10.1CD79A
37poems syndrome10.1CD79A
38pyelonephritis10.1CD79A
39egg allergy10.1IL5, IGHE
40acute poststreptococcal glomerulonephritis10.1CD79A
41intrinsic asthma10.1IL5, IGHE
42paragonimiasis10.1IL5, IGHE
43epidermolysis bullosa acquisita10.1CD79A
44allergic bronchopulmonary aspergillosis10.1IGHE, IL5
45kimura disease10.1IGHE, IL5
46contact dermatitis10.1IL5, IGHE
47chronic eosinophilic pneumonia10.1IL5, CCL11
48giant papillary conjunctivitis10.1IL5, CCL11
49thyroiditis10.1CD79A
50omenn syndrome10.1IGHE, IL5

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to strongyloidiasis

Symptoms for Strongyloidiasis

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Drugs & Therapeutics for Strongyloidiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Strongyloidiasis

Drug clinical trials:

Search ClinicalTrials for Strongyloidiasis

Search NIH Clinical Center for Strongyloidiasis

Search CenterWatch for Strongyloidiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Strongyloidiasis

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Anatomical Context for Strongyloidiasis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Strongyloidiasis:

34
Skin, Lung, T cells, Testes, Kidney, Colon, Liver, Heart, Breast

Animal Models for Strongyloidiasis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Strongyloidiasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7TP53, IFNG, IL5, ALB, TGFB1
2MP:00053708.7TGFB1, IFNG, IL5, ALB, TP53
3MP:00028738.6CCL11, ALB, IFNG, TP53, CD79A
4MP:00053888.6IFNG, IL5, CCL11, TGFB1, TP53
5MP:00053678.6TGFB1, TP53, CD79A, ALB, IFNG
6MP:00053818.3ALB, TGFB1, IL5, IFNG, TP53
7MP:00053977.4CD7, CD79A, IL5, IFNG, CCL11, TGFB1
8MP:00053767.4ALB, IL5, IFNG, LGALS3BP, TGFB1, TP53
9MP:00053876.9LGALS3BP, IGHE, CCL11, TP53, CD7, CD79A

Publications for Strongyloidiasis

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Sources:
53PubMed
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Articles related to Strongyloidiasis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. (23592987)
2013
2
Strongyloidiasis presenting as larva currens 38 years after presumed exposure. (23149200)
2012
3
Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin. (22975175)
2012
4
A series on intestinal strongyloidiasis in immunocompetent and immunocompromised hosts. (23025061)
2012
5
IgG avidity in differential serodiagnosis of human strongyloidiasis active infection. (21699917)
2011
6
Uncomplicated strongyloidiasis in a liver transplant recipient on steroid-free immunosuppression. (20487417)
2010
7
Eosinophilia and the seroprevalence of schistosomiasis and strongyloidiasis in newly arrived pediatric refugees: an examination of Centers for Disease Control and Prevention screening guidelines. (20400098)
2010
8
Pulmonary strongyloidiasis. (20329418)
2009
9
Strongyloidiasis: endoscopic diagnosis. (18955162)
2009
10
Identification of a 26-kDa protein fraction as an important antigen for application in the immunodiagnosis of strongyloidiasis. (17569087)
2007
11
IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen. (17610082)
2007
12
Evaluation of an indirect immunofluorescence assay for strongyloidiasis as a tool for diagnosis and follow-up. (17135451)
2007
13
Disseminated strongyloidiasis and cytomegalovirus infection in a patient with anaplastic large cell lymphoma. (17641892)
2007
14
Strongyloidiasis stercoralis: is it a health problem in Saudi Arabia? (17366869)
2006
15
Intestinal strongyloidiasis and common variable immunodeficiency syndrome. (15876606)
2005
16
Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease? (16410894)
2005
17
Successful use of parenteral ivermectin in an immunosuppressed patient with disseminated strongyloidiasis and septic shock. (16041520)
2005
18
Severe gastrointestinal strongyloidiasis. (16082494)
2005
19
Successful ivermectin treatment of hepatic strongyloidiasis presenting with severe eosinophilia. (15455986)
2004
20
Why does HIV infection not lead to disseminated strongyloidiasis? (15551217)
2004
21
Pulmonary strongyloidiasis presenting as chronic bronchitis leading to interlobular septal fibrosis and cured by treatment. (14708557)
2003
22
Strongyloides venezuelensis alkaline extract for the diagnosis of human strongyloidiasis by enzyme-linked immunosorbent assay. (14595467)
2003
23
Strongyloidiasis and natural killer cell lymphocytosis. (10809888)
2000
24
Pulmonary strongyloidiasis--case report of 2 cases. (10969524)
2000
25
High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis. (11042682)
2000
26
Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies). (10096585)
1999
27
Strongyloidiasis, angio-oedema and natural killer cell lymphocytosis. (10354098)
1999
28
Parasite-specific serum IgG following successful treatment of endemic strongyloidiasis using ivermectin. (9015524)
1996
29
Fulminant, systemic strongyloidiasis in AIDS. (8758145)
1996
30
Expression of CD23, CD32, Mac-1 and other adhesion molecules in eosinophils in strongyloidiasis and HTLV-I-positive patients. (8906113)
1996
31
Interrelation of strongyloidiasis and tuberculosis. (8063205)
1994
32
Strongyloides stercoralis: the first rodent model for uncomplicated and hyperinfective strongyloidiasis, the Mongolian gerbil (Meriones unguiculatus). (8245532)
1993
33
Direct and indirect diagnosis of strongyloidiasis. (1578156)
1992
34
Fatal adult respiratory distress syndrome following successful treatment of pulmonary strongyloidiasis. (1995245)
1991
35
Aphthoid ulceration of the colon in strongyloidiasis. (2028960)
1991
36
Gelatin particle indirect agglutination test for mass examination for strongyloidiasis. (1755062)
1991
37
Strongyloidiasis associated with human T-cell lymphotropic virus type I infection in a nonendemic area. (2588581)
1989
38
Diagnosis of pulmonary strongyloidiasis by bronchoalveolar lavage. (3409752)
1988
39
Endemic institutional strongyloidiasis in British Columbia. (3607675)
1987
40
Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. (2886441)
1987
41
Seroepidemiology of strongyloidiasis in a Thai village. (3429125)
1987
42
Concentrations of thiabendazole and parasite-specific IgG antibodies in the cerebrospinal fluid of a patient with disseminated strongyloidiasis. (3611836)
1987
43
Indigenous strongyloidiasis in Nottingham. (3109595)
1987
44
Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis. (3711300)
1986
45
Risk factors for strongyloidiasis. A case-control study. (6696569)
1984
46
Cambendazole in the treatment of human strongyloidiasis. (6625071)
1983
47
Immunological features in different clinical forms of strongyloidiasis. (6623593)
1983
48
Pulmonary strongyloidiasis. (7063915)
1982
49
Strongyloidiasis and chronic urticaria. (7111108)
1982
50
Transmission of strongyloidiasis by kidney transplant? Disseminated strongyloidiasis in both recipients of kidney allografts from a single cadaver donor. (7026811)
1981

Variations for Strongyloidiasis

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Expression for genes affiliated with Strongyloidiasis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for genes affiliated with Strongyloidiasis

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 31KEGG, 61Thomson Reuters, 13EMD Millipore
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Pathways related to Strongyloidiasis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL5
29.9IL5, IFNG
39.9IFNG, IL5
49.8TGFB1, IL5
5
Show member pathways
9.8IFNG, TGFB1
69.8IFNG, TGFB1
79.5IL5, IFNG, TGFB1
8
Show member pathways
9.5IL5, IFNG, TGFB1
99.4TP53, IFNG, IL5
109.4IGHE, IL5, CCL11
11
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.4IGHE, CD79A, IL5
12
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.3IFNG, TGFB1, TP53
139.3IFNG, TGFB1, TP53
149.3IFNG, TGFB1, TP53
159.3TP53, TGFB1, IFNG
16
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.2IGHE, CCL11, TP53
17
Show member pathways
9.2TGFB1, CCL11, IFNG, IL5
18
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.2IFNG, TGFB1, IL5, CD79A
19
Show member pathways
9.1IL5, TGFB1, CCL11, TP53
20
Show member pathways
8.7IFNG, TP53, TGFB1, IL5, CCL11
21
Show member pathways
8.7TGFB1, IL5, TP53, IFNG, CCL11

Compounds for genes affiliated with Strongyloidiasis

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Strongyloidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1clarithromycin46 1210.9CCL11, CD79A, IL5
2pirfenidone46 6210.8TGFB1, IFNG, IL5
3gamma globulin469.8CD79A, ALB, IFNG
4con a469.8CD79A, IL5, IFNG
5cetirizine46 30 25 1212.8IGHE, CCL11, IL5
6l-tryptophan52 30 46 25 1213.8ALB, IFNG, IL5
7ketotifen46 1210.7IL5, CCL11, IGHE
8rolipram46 62 3011.7CCL11, IFNG, IL5
9praziquantel46 1210.7IGHE, CD79A, IL5
10ramipril46 1210.7TGFB1, CD79A, ALB
11gm-csf46 3010.7IL5, IFNG, TGFB1
12penicillin469.7IL5, CD79A, IGHE
13montelukast46 52 30 1212.7IGHE, IL5, CCL11
14hhpa469.7ALB, IGHE
15poly(i-c)469.6CCL11, IFNG, IL5
16sulfamethoxazole52 46 1211.6IL5, IGHE, ALB
17glutaraldehyde469.6TGFB1, CD79A, ALB
18pgd2469.5IGHE, CCL11, IL5
19unicap469.5IL5, CCL11, CD79A, IGHE
20sodium cromoglycate469.5CD79A, IL5, CCL11, IGHE
21methylcellulose469.5IL5, IFNG, TGFB1
22salbutamol46 52 30 25 1213.5CD79A, IGHE, CCL11, IL5
23budesonide46 52 1211.5IFNG, IGHE, CCL11, IL5
24fluticasone propionate46 52 62 1212.5IL5, IFNG, IGHE, CCL11
25tarc469.5IGHE, IL5, IFNG, CCL11
26mycophenolate mofetil46 52 1211.4ALB, CD79A, IFNG
27hyaluronic acid46 2510.4TGFB1, CCL11, ALB, CD79A
28il 10469.2IL5, TGFB1, IFNG
29pge2469.2CCL11, CD79A, IL5, TGFB1, IFNG
30allergens469.2IFNG, CCL11, IGHE, IL5, CD79A
31methacholine46 52 1211.1CD79A, IGHE, TGFB1, CCL11, IL5
32sb 20358046 6210.1IL5, IFNG, CCL11, TGFB1, TP53
33butyrate469.1IL5, IFNG, CCL11, TGFB1, TP53
34rantes469.1IFNG, IL5, CCL11, TGFB1
35ivig469.0IL5, CD79A, IFNG, IGHE, ALB
36thymidine46 2510.0CCL11, TGFB1, TP53, IL5, IFNG
37thyroxine46 2510.0IGHE, IL5, CD79A, ALB, TGFB1
38methotrexate52 46 1211.0CD79A, ALB, IL5, IGHE, TGFB1
39vitamin d469.0IL5, IGHE, ALB, TGFB1, CD79A
40heparin46 30 25 1211.9CD79A, ALB, IL5, CCL11, IGHE
41tacrolimus46 52 1210.9TGFB1, ALB, CCL11, CD79A, IFNG, IL5
42actinomycin d468.8TP53, IGHE, TGFB1, CCL11, IFNG
43cyclosporin a46 30 6210.8IL5, CD79A, IFNG, IGHE, CCL11, TGFB1
44prednisolone46 30 1210.8ALB, CD79A, IL5, IFNG, CCL11, IGHE
45dexamethasone46 52 30 1211.7IL5, CD79A, IFNG, TGFB1, CCL11, IGHE
46cycloheximide468.7IFNG, IL5, TGFB1, TP53, IGHE
47indomethacin46 30 62 1211.4CD79A, ALB, IL5, IFNG, CCL11, TGFB1
48histamine46 30 2510.4IGHE, IFNG, CD79A, TGFB1, ALB, IL5
49vegf468.3CCL11, IL5, CD79A, IFNG, TGFB1, TP53
50retinoic acid46 259.3TP53, TGFB1, CCL11, IFNG, IL5, CD79A

GO Terms for genes affiliated with Strongyloidiasis

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Sources:
17Gene Ontology
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Cellular components related to Strongyloidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.2ALB, LGALS3BP, TGFB1
2extracellular spaceGO:0056158.2IL5, TGFB1, LGALS3BP, CCL11, IFNG, ALB
3extracellular regionGO:0055768.0ALB, IGHE, TGFB1, CCL11, IFNG, IL5

Biological processes related to Strongyloidiasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuroblast proliferationGO:0074069.8TGFB1, TP53
2positive regulation of histone deacetylationGO:0310659.8TGFB1, TP53
3positive regulation of cell cycle arrestGO:0711589.7TGFB1, TP53
4response to radiationGO:0093149.7TGFB1, CCL11
5negative regulation of DNA replicationGO:0081569.6TGFB1, TP53
6inflammatory responseGO:0069549.5IL5, CCL11, TGFB1
7protein import into nucleus, translocationGO:0000609.5IFNG, TGFB1, TP53
8extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TGFB1
9cell cycle arrestGO:0070509.4TP53, TGFB1, IFNG
10immune responseGO:0069559.0IGHE, CCL11, IL5, CD7

Molecular functions related to Strongyloidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.2ALB, TGFB1, TP53

Products for genes affiliated with Strongyloidiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Strongyloidiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet