MCID: STR008
MIFTS: 66

Strongyloidiasis malady

Rare diseases, Infectious diseases categories
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Summaries for Strongyloidiasis

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NIH Rare Diseases:42 Strongyloidiasis is a parasitic disease caused by the roundworm strongyloides stercoralis (s. stercoralis). people catch the infection when they come in contact with soil contaminated with the worms. while there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. the infection is treated with anti-worm medications such as ivermectin. strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern united states. last updated: 9/20/2010

MalaCards based summary: Strongyloidiasis, also known as disseminated strongyloidiasis, is related to filariasis and folliculitis. An important gene associated with Strongyloidiasis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Inflammatory Response Pathway and Cytokine Network. The drugs albendazole and mebendazole and the compounds clarithromycin and pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode strongyloides stercoralis.

CDC:3 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Wikipedia:65 Strongyloidiasis is a human parasitic disease caused by the nematode (roundworm) Strongyloides... more...

Aliases & Classifications for Strongyloidiasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Strongyloidiasis, Aliases & Descriptions:

Name: Strongyloidiasis 8 42 10 44 48 62
Disseminated Strongyloidiasis 8 62
Infection by Strongyloides 8 62
Threadworm Infection 42 62
 
Anguilluliasis 48 62
Strongyloidiasis, Unspecified 8
Anguillulosis 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
strongyloidiasis:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:10955
ICD9CM27 127.2
MeSH34 D013322
UMLS via Orphanet63 C0038463
MESH via Orphanet35 D013322
ICD10 via Orphanet26 B78.0, B78.1, B78.7 B78.9, more
ICD1025 B78, B78.7, B78.9

Related Diseases for Strongyloidiasis

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Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1filariasis30.9IGHE, IL5
2folliculitis30.7CCL11
3giardiasis30.6CD79A
4amebiasis30.6CD79A
5schistosomiasis30.6CD79A, IL5, IFNG, IGHE
6cryptosporidiosis30.5CD79A
7helminthiasis30.5IL5, IGHE
8paragonimiasis30.5IL5, IGHE
9asthma30.5IGHE, IL5
10nephrotic syndrome30.5CCL11, CD79A, ALB
11eosinophilia30.4IL5, CD79A, IFNG, CCL11, IGHE
12protein-losing enteropathy30.3ALB
13bronchitis30.3IGHE, IL5, CCL11
14meningitis30.2CD79A, ALB
15candidiasis30.1IFNG, CD79A
16ulcerative colitis29.9CCL11, IFNG, CD79A
17glomerulonephritis29.8TGFB1, ALB, CD79A
18pneumonia29.8TGFB1, CCL11, CD79A, IL5
19dermatitis29.7CD79A, IL5, IFNG, IGHE, CCL11
20lung cancer29.7TGFB1, TP53, LGALS3BP
21leukemia29.6TP53, CD79A, CD7, IFNG, CCL11, TGFB1
22tuberculosis29.6IFNG, CD79A, ALB
23eosinophilic fasciitis10.6IL5
24eosinophilia-myalgia syndrome10.6IL5
25eczema herpeticum10.5IGHE
26gastroenteritis10.5CD79A
27exanthem10.5CD79A
28common cold10.5CCL11
29henoch-schoenlein purpura10.5CD79A
30poems syndrome10.5CD79A
31pyelonephritis10.4CD79A
32egg allergy10.4IL5, IGHE
33acute poststreptococcal glomerulonephritis10.4CD79A
34intrinsic asthma10.4IL5, IGHE
35epidermolysis bullosa acquisita10.4CD79A
36allergic bronchopulmonary aspergillosis10.4IGHE, IL5
37kimura disease10.4IGHE, IL5
38contact dermatitis10.4IL5, IGHE
39chronic eosinophilic pneumonia10.4IL5, CCL11
40giant papillary conjunctivitis10.4IL5, CCL11
41thyroiditis10.4CD79A
42omenn syndrome10.4IGHE, IL5
43eosinophilic esophagitis10.4CCL11, IL5
44keratoconjunctivitis10.4CCL11, IL5
45conjunctivitis10.4IGHE, CD79A
46mastocytosis10.4IGHE, IL5
47duodenitis10.4
48angioedema10.4IL5, IGHE
49immunoglobulin g deficiency10.4CD79A, IGHE
50immunoglobulin alpha deficiency10.3CD79A, IGHE

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to strongyloidiasis

Symptoms for Strongyloidiasis

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Drugs & Therapeutics for Strongyloidiasis

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Drug clinical trials:

Search ClinicalTrials for Strongyloidiasis

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Strongyloidiasis

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Anatomical Context for Strongyloidiasis

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MalaCards organs/tissues related to Strongyloidiasis:

32
Skin, Lung, T cells, Testes, Kidney, Colon, Liver, Heart, Breast

Animal Models for Strongyloidiasis or affiliated genes

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MGI Mouse Phenotypes related to Strongyloidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7TP53, TGFB1, IFNG, IL5, ALB
2MP:00053708.7ALB, IL5, IFNG, TGFB1, TP53
3MP:00028738.6CD79A, ALB, IFNG, CCL11, TP53
4MP:00053888.6TP53, TGFB1, CCL11, IFNG, IL5
5MP:00053678.6TP53, TGFB1, IFNG, ALB, CD79A
6MP:00053818.3TP53, TGFB1, IFNG, IL5, ALB
7MP:00053977.4IGHE, TP53, TGFB1, CCL11, IFNG, IL5
8MP:00053767.4IGHE, TP53, TGFB1, LGALS3BP, IFNG, IL5
9MP:00053876.9CD7, IGHE, TP53, TGFB1, LGALS3BP, CCL11

Publications for Strongyloidiasis

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Articles related to Strongyloidiasis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Update on immunologic and molecular diagnosis of human strongyloidiasis. (24686097)
2014
2
Strongyloidiasis hyperinfection in a patient with a history of systemic lupus erythematosus. (25092815)
2014
3
Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. (23592987)
2013
4
Strongyloidiasis presenting as larva currens 38 years after presumed exposure. (23149200)
2012
5
Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin. (22975175)
2012
6
A series on intestinal strongyloidiasis in immunocompetent and immunocompromised hosts. (23025061)
2012
7
IgG avidity in differential serodiagnosis of human strongyloidiasis active infection. (21699917)
2011
8
Uncomplicated strongyloidiasis in a liver transplant recipient on steroid-free immunosuppression. (20487417)
2010
9
Pulmonary strongyloidiasis. (20329418)
2009
10
Strongyloidiasis: endoscopic diagnosis. (18955162)
2009
11
Identification of a 26-kDa protein fraction as an important antigen for application in the immunodiagnosis of strongyloidiasis. (17569087)
2007
12
IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen. (17610082)
2007
13
Evaluation of an indirect immunofluorescence assay for strongyloidiasis as a tool for diagnosis and follow-up. (17135451)
2007
14
Disseminated strongyloidiasis and cytomegalovirus infection in a patient with anaplastic large cell lymphoma. (17641892)
2007
15
Strongyloidiasis stercoralis: is it a health problem in Saudi Arabia? (17366869)
2006
16
Intestinal strongyloidiasis and common variable immunodeficiency syndrome. (15876606)
2005
17
Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease? (16410894)
2005
18
Successful use of parenteral ivermectin in an immunosuppressed patient with disseminated strongyloidiasis and septic shock. (16041520)
2005
19
Severe gastrointestinal strongyloidiasis. (16082494)
2005
20
Successful ivermectin treatment of hepatic strongyloidiasis presenting with severe eosinophilia. (15455986)
2004
21
Pulmonary strongyloidiasis presenting as chronic bronchitis leading to interlobular septal fibrosis and cured by treatment. (14708557)
2003
22
Strongyloides venezuelensis alkaline extract for the diagnosis of human strongyloidiasis by enzyme-linked immunosorbent assay. (14595467)
2003
23
Strongyloidiasis and natural killer cell lymphocytosis. (10809888)
2000
24
Pulmonary strongyloidiasis--case report of 2 cases. (10969524)
2000
25
High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis. (11042682)
2000
26
Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies). (10096585)
1999
27
Strongyloidiasis, angio-oedema and natural killer cell lymphocytosis. (10354098)
1999
28
Parasite-specific serum IgG following successful treatment of endemic strongyloidiasis using ivermectin. (9015524)
1996
29
Fulminant, systemic strongyloidiasis in AIDS. (8758145)
1996
30
Expression of CD23, CD32, Mac-1 and other adhesion molecules in eosinophils in strongyloidiasis and HTLV-I-positive patients. (8906113)
1996
31
Interrelation of strongyloidiasis and tuberculosis. (8063205)
1994
32
Strongyloides stercoralis: the first rodent model for uncomplicated and hyperinfective strongyloidiasis, the Mongolian gerbil (Meriones unguiculatus). (8245532)
1993
33
Direct and indirect diagnosis of strongyloidiasis. (1578156)
1992
34
Fatal adult respiratory distress syndrome following successful treatment of pulmonary strongyloidiasis. (1995245)
1991
35
Aphthoid ulceration of the colon in strongyloidiasis. (2028960)
1991
36
Gelatin particle indirect agglutination test for mass examination for strongyloidiasis. (1755062)
1991
37
Strongyloidiasis associated with human T-cell lymphotropic virus type I infection in a nonendemic area. (2588581)
1989
38
Diagnosis of pulmonary strongyloidiasis by bronchoalveolar lavage. (3409752)
1988
39
Endemic institutional strongyloidiasis in British Columbia. (3607675)
1987
40
Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. (2886441)
1987
41
Seroepidemiology of strongyloidiasis in a Thai village. (3429125)
1987
42
Concentrations of thiabendazole and parasite-specific IgG antibodies in the cerebrospinal fluid of a patient with disseminated strongyloidiasis. (3611836)
1987
43
Indigenous strongyloidiasis in Nottingham. (3109595)
1987
44
Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis. (3711300)
1986
45
Risk factors for strongyloidiasis. A case-control study. (6696569)
1984
46
Cambendazole in the treatment of human strongyloidiasis. (6625071)
1983
47
Immunological features in different clinical forms of strongyloidiasis. (6623593)
1983
48
Pulmonary strongyloidiasis. (7063915)
1982
49
Strongyloidiasis and chronic urticaria. (7111108)
1982
50
Transmission of strongyloidiasis by kidney transplant? Disseminated strongyloidiasis in both recipients of kidney allografts from a single cadaver donor. (7026811)
1981

Variations for Strongyloidiasis

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Expression for genes affiliated with Strongyloidiasis

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Expression patterns in normal tissues for genes affiliated with Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for genes affiliated with Strongyloidiasis

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Pathways related to Strongyloidiasis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL5
29.9IL5, IFNG
39.9IL5, IFNG
49.8IL5, TGFB1
5
Show member pathways
9.8IFNG, TGFB1
69.8IFNG, TGFB1
79.5IL5, IFNG, TGFB1
8
Show member pathways
9.5IL5, IFNG, TGFB1
99.4IL5, IFNG, TP53
109.4IL5, CCL11, IGHE
11
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.4IGHE, IL5, CD79A
12
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.3IFNG, TGFB1, TP53
139.3IFNG, TGFB1, TP53
149.3IFNG, TGFB1, TP53
159.3TP53, TGFB1, IFNG
16
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.2IGHE, TP53, CCL11
17
Show member pathways
9.2IL5, IFNG, CCL11, TGFB1
18
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.2TGFB1, IFNG, IL5, CD79A
19
Show member pathways
9.1IL5, CCL11, TGFB1, TP53
20
Show member pathways
8.7TP53, TGFB1, CCL11, IFNG, IL5
21
Show member pathways
8.7TP53, TGFB1, CCL11, IFNG, IL5

Compounds for genes affiliated with Strongyloidiasis

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Compounds related to Strongyloidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1clarithromycin44 1110.9CCL11, CD79A, IL5
2pirfenidone44 6110.8TGFB1, IFNG, IL5
3gamma globulin449.8CD79A, ALB, IFNG
4con a449.8CD79A, IL5, IFNG
5cetirizine44 28 24 1112.8IGHE, CCL11, IL5
6l-tryptophan50 28 44 24 1113.8ALB, IFNG, IL5
7ketotifen44 1110.7IL5, CCL11, IGHE
8rolipram44 61 2811.7CCL11, IFNG, IL5
9praziquantel44 1110.7IGHE, CD79A, IL5
10ramipril44 1110.7TGFB1, CD79A, ALB
11gm-csf44 2810.7IL5, IFNG, TGFB1
12penicillin449.7IL5, CD79A, IGHE
13montelukast44 50 28 1112.7IGHE, IL5, CCL11
14hhpa449.7ALB, IGHE
15poly(i-c)449.6CCL11, IFNG, IL5
16sulfamethoxazole50 44 1111.6IL5, IGHE, ALB
17glutaraldehyde449.6TGFB1, CD79A, ALB
18pgd2449.5IGHE, CCL11, IL5
19unicap449.5IL5, CCL11, CD79A, IGHE
20sodium cromoglycate449.5CD79A, IL5, CCL11, IGHE
21methylcellulose449.5IL5, IFNG, TGFB1
22salbutamol44 50 28 24 1113.5CD79A, IGHE, CCL11, IL5
23budesonide44 50 1111.5IFNG, IGHE, CCL11, IL5
24fluticasone propionate44 50 61 1112.5IL5, IFNG, IGHE, CCL11
25tarc449.5IGHE, IL5, IFNG, CCL11
26mycophenolate mofetil44 50 1111.4ALB, CD79A, IFNG
27hyaluronic acid44 2410.4TGFB1, CCL11, ALB, CD79A
28il 10449.2IL5, TGFB1, IFNG
29pge2449.2CCL11, CD79A, IL5, TGFB1, IFNG
30allergens449.2IFNG, CCL11, IGHE, IL5, CD79A
31methacholine44 50 1111.1CD79A, IGHE, TGFB1, CCL11, IL5
32sb 20358044 6110.1IL5, IFNG, CCL11, TGFB1, TP53
33butyrate449.1IL5, IFNG, CCL11, TGFB1, TP53
34rantes449.1IFNG, IL5, CCL11, TGFB1
35ivig449.0IL5, CD79A, IFNG, IGHE, ALB
36thymidine44 2410.0CCL11, TGFB1, TP53, IL5, IFNG
37thyroxine44 2410.0IGHE, IL5, CD79A, ALB, TGFB1
38methotrexate50 44 1111.0CD79A, ALB, IL5, IGHE, TGFB1
39vitamin d449.0IL5, IGHE, ALB, TGFB1, CD79A
40heparin44 28 24 1111.9CD79A, ALB, IL5, CCL11, IGHE
41tacrolimus44 50 1110.9TGFB1, ALB, CCL11, CD79A, IFNG, IL5
42actinomycin d448.8TP53, IGHE, TGFB1, CCL11, IFNG
43cyclosporin a44 28 6110.8IL5, CD79A, IFNG, IGHE, CCL11, TGFB1
44prednisolone44 28 1110.8ALB, CD79A, IL5, IFNG, CCL11, IGHE
45dexamethasone44 50 28 1111.7IL5, CD79A, IFNG, TGFB1, CCL11, IGHE
46cycloheximide448.7IFNG, IL5, TGFB1, TP53, IGHE
47indomethacin44 28 61 1111.4CD79A, ALB, IL5, IFNG, CCL11, TGFB1
48histamine44 28 2410.4IGHE, IFNG, CD79A, TGFB1, ALB, IL5
49vegf448.3CCL11, IL5, CD79A, IFNG, TGFB1, TP53
50retinoic acid44 249.3TP53, TGFB1, CCL11, IFNG, IL5, CD79A

GO Terms for genes affiliated with Strongyloidiasis

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Cellular components related to Strongyloidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.2ALB, LGALS3BP, TGFB1
2extracellular spaceGO:0056158.2ALB, IL5, IFNG, CCL11, LGALS3BP, TGFB1
3extracellular regionGO:0055768.0IGHE, TGFB1, CCL11, IFNG, IL5, ALB

Biological processes related to Strongyloidiasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuroblast proliferationGO:0074069.8TGFB1, TP53
2positive regulation of histone deacetylationGO:0310659.8TGFB1, TP53
3positive regulation of cell cycle arrestGO:0711589.7TGFB1, TP53
4response to radiationGO:0093149.7TGFB1, CCL11
5negative regulation of DNA replicationGO:0081569.6TGFB1, TP53
6inflammatory responseGO:0069549.5IL5, CCL11, TGFB1
7protein import into nucleus, translocationGO:0000609.5IFNG, TGFB1, TP53
8extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TGFB1
9cell cycle arrestGO:0070509.4TP53, TGFB1, IFNG
10immune responseGO:0069559.0IGHE, CCL11, IL5, CD7

Molecular functions related to Strongyloidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.2ALB, TGFB1, TP53

Products for genes affiliated with Strongyloidiasis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Strongyloidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet