MCID: STR008
MIFTS: 64

Strongyloidiasis malady

Rare diseases, Infectious diseases categories
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Summaries for Strongyloidiasis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 4CDC, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Strongyloidiasis is a parasitic disease caused by the roundworm strongyloides stercoralis (s. stercoralis). people catch the infection when they come in contact with soil contaminated with the worms. while there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. the infection is treated with anti-worm medications such as ivermectin. strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern united states. last updated: 9/20/2010

MalaCards: Strongyloidiasis, also known as disseminated strongyloidiasis, is related to eosinophilia and nephrotic syndrome. An important gene associated with Strongyloidiasis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Inflammatory Response Pathway and Cytokine Network. The drugs ivermectin and thiabendazole and the compounds clarithromycin and pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode strongyloides stercoralis.

CDC:4 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Wikipedia:65 Strongyloidiasis is a human parasitic disease caused by the nematode (roundworm) Strongyloides... more...

Aliases & Classifications for Strongyloidiasis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
strongyloidiasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

strongyloidiasis 8 43 10 45 49 62
disseminated strongyloidiasis 8 62
anguilluliasis 49 62
strongyloidiasis, unspecified 8
infection by strongyloides 8
threadworm infection 43
anguillulosis 49


External Ids:

Disease Ontology8 DOID:10955
MeSH35 D013322
ICD9CM27 127.2
MESH via Orphanet36 D013322
SNOMED-CT via Orphanet59 1214006
UMLS via Orphanet63 C0038463
ICD10 via Orphanet26 B78.0, B78.1, B78.7 B78.9, more
ICD1025 B78, B78.7, B78.9

Related Diseases for Strongyloidiasis

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17GeneCards, 18GeneDecks
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Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia30.6IL5, CD79A, IFNG, CCL11, IGHE
2nephrotic syndrome30.5CCL11, CD79A, ALB
3schistosomiasis30.5CD79A, IL5, IFNG, IGHE
4meningitis30.4CD79A, ALB
5filariasis30.4IGHE, IL5
6leukemia30.2TP53, CD79A, CD7, IFNG, CCL11, TGFB1
7folliculitis30.0CCL11
8glomerulonephritis30.0TGFB1, ALB, CD79A
9amebiasis30.0CD79A
10cryptosporidiosis30.0CD79A
11helminthiasis30.0IL5, IGHE
12asthma30.0IGHE, IL5
13bronchitis30.0IGHE, IL5, CCL11
14candidiasis29.9IFNG, CD79A
15ulcerative colitis29.9CCL11, IFNG, CD79A
16pneumonia29.8TGFB1, CCL11, CD79A, IL5
17dermatitis29.8CD79A, IL5, IFNG, IGHE, CCL11
18lung cancer29.8TGFB1, TP53, LGALS3BP
19tuberculosis29.8IFNG, CD79A, ALB
20duodenitis10.4
21acquired immunodeficiency syndrome10.3
22purpura10.3
23paralytic ileus10.2
24adult t-cell leukemia10.2
25t-cell leukemia10.2
26ileus10.2
27common variable immunodeficiency10.1
28isosporiasis10.1
29eosinophilic fasciitis10.1IL5
30eosinophilia-myalgia syndrome10.1IL5
31eczema herpeticum10.1IGHE
32gastroenteritis10.1CD79A
33exanthem10.1CD79A
34common cold10.1CCL11
35henoch-schoenlein purpura10.1CD79A
36giardiasis10.1CD79A
37poems syndrome10.1CD79A
38pyelonephritis10.1CD79A
39egg allergy10.1IL5, IGHE
40acute poststreptococcal glomerulonephritis10.1CD79A
41intrinsic asthma10.1IL5, IGHE
42paragonimiasis10.1IL5, IGHE
43epidermolysis bullosa acquisita10.1CD79A
44allergic bronchopulmonary aspergillosis10.1IGHE, IL5
45kimura disease10.1IGHE, IL5
46contact dermatitis10.1IL5, IGHE
47chronic eosinophilic pneumonia10.1IL5, CCL11
48giant papillary conjunctivitis10.1IL5, CCL11
49thyroiditis10.1CD79A
50omenn syndrome10.1IGHE, IL5

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to strongyloidiasis

Symptoms for Strongyloidiasis

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Drugs & Therapeutics for Strongyloidiasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Strongyloidiasis

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Strongyloidiasis

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Anatomical Context for Strongyloidiasis

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33MalaCards
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MalaCards organs/tissues related to Strongyloidiasis:

33
Skin, Lung, T cells, Testes, Kidney, Colon, Liver, Heart, Breast

Animal Models for Strongyloidiasis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Strongyloidiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7TP53, IFNG, IL5, ALB, TGFB1
2MP:00053708.7TGFB1, IFNG, IL5, ALB, TP53
3MP:00028738.6CCL11, ALB, IFNG, TP53, CD79A
4MP:00053888.6IFNG, IL5, CCL11, TGFB1, TP53
5MP:00053678.6TGFB1, TP53, CD79A, ALB, IFNG
6MP:00053818.3ALB, TGFB1, IL5, IFNG, TP53
7MP:00053977.4CD7, CD79A, IL5, IFNG, CCL11, TGFB1
8MP:00053767.4ALB, IL5, IFNG, LGALS3BP, TGFB1, TP53
9MP:00053876.9LGALS3BP, IGHE, CCL11, TP53, CD7, CD79A

Publications for Strongyloidiasis

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Sources:
52PubMed
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Articles related to Strongyloidiasis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. (23592987)
2013
2
Strongyloidiasis presenting as larva currens 38 years after presumed exposure. (23149200)
2012
3
Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin. (22975175)
2012
4
A series on intestinal strongyloidiasis in immunocompetent and immunocompromised hosts. (23025061)
2012
5
IgG avidity in differential serodiagnosis of human strongyloidiasis active infection. (21699917)
2011
6
Uncomplicated strongyloidiasis in a liver transplant recipient on steroid-free immunosuppression. (20487417)
2010
7
Eosinophilia and the seroprevalence of schistosomiasis and strongyloidiasis in newly arrived pediatric refugees: an examination of Centers for Disease Control and Prevention screening guidelines. (20400098)
2010
8
Pulmonary strongyloidiasis. (20329418)
2009
9
Strongyloidiasis: endoscopic diagnosis. (18955162)
2009
10
Identification of a 26-kDa protein fraction as an important antigen for application in the immunodiagnosis of strongyloidiasis. (17569087)
2007
11
IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen. (17610082)
2007
12
Evaluation of an indirect immunofluorescence assay for strongyloidiasis as a tool for diagnosis and follow-up. (17135451)
2007
13
Disseminated strongyloidiasis and cytomegalovirus infection in a patient with anaplastic large cell lymphoma. (17641892)
2007
14
Strongyloidiasis stercoralis: is it a health problem in Saudi Arabia? (17366869)
2006
15
Intestinal strongyloidiasis and common variable immunodeficiency syndrome. (15876606)
2005
16
Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease? (16410894)
2005
17
Successful use of parenteral ivermectin in an immunosuppressed patient with disseminated strongyloidiasis and septic shock. (16041520)
2005
18
Severe gastrointestinal strongyloidiasis. (16082494)
2005
19
Successful ivermectin treatment of hepatic strongyloidiasis presenting with severe eosinophilia. (15455986)
2004
20
Why does HIV infection not lead to disseminated strongyloidiasis? (15551217)
2004
21
Pulmonary strongyloidiasis presenting as chronic bronchitis leading to interlobular septal fibrosis and cured by treatment. (14708557)
2003
22
Strongyloides venezuelensis alkaline extract for the diagnosis of human strongyloidiasis by enzyme-linked immunosorbent assay. (14595467)
2003
23
Strongyloidiasis and natural killer cell lymphocytosis. (10809888)
2000
24
Pulmonary strongyloidiasis--case report of 2 cases. (10969524)
2000
25
High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis. (11042682)
2000
26
Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies). (10096585)
1999
27
Strongyloidiasis, angio-oedema and natural killer cell lymphocytosis. (10354098)
1999
28
Parasite-specific serum IgG following successful treatment of endemic strongyloidiasis using ivermectin. (9015524)
1996
29
Fulminant, systemic strongyloidiasis in AIDS. (8758145)
1996
30
Expression of CD23, CD32, Mac-1 and other adhesion molecules in eosinophils in strongyloidiasis and HTLV-I-positive patients. (8906113)
1996
31
Interrelation of strongyloidiasis and tuberculosis. (8063205)
1994
32
Strongyloides stercoralis: the first rodent model for uncomplicated and hyperinfective strongyloidiasis, the Mongolian gerbil (Meriones unguiculatus). (8245532)
1993
33
Direct and indirect diagnosis of strongyloidiasis. (1578156)
1992
34
Fatal adult respiratory distress syndrome following successful treatment of pulmonary strongyloidiasis. (1995245)
1991
35
Aphthoid ulceration of the colon in strongyloidiasis. (2028960)
1991
36
Gelatin particle indirect agglutination test for mass examination for strongyloidiasis. (1755062)
1991
37
Strongyloidiasis associated with human T-cell lymphotropic virus type I infection in a nonendemic area. (2588581)
1989
38
Diagnosis of pulmonary strongyloidiasis by bronchoalveolar lavage. (3409752)
1988
39
Endemic institutional strongyloidiasis in British Columbia. (3607675)
1987
40
Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. (2886441)
1987
41
Seroepidemiology of strongyloidiasis in a Thai village. (3429125)
1987
42
Concentrations of thiabendazole and parasite-specific IgG antibodies in the cerebrospinal fluid of a patient with disseminated strongyloidiasis. (3611836)
1987
43
Indigenous strongyloidiasis in Nottingham. (3109595)
1987
44
Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis. (3711300)
1986
45
Risk factors for strongyloidiasis. A case-control study. (6696569)
1984
46
Cambendazole in the treatment of human strongyloidiasis. (6625071)
1983
47
Immunological features in different clinical forms of strongyloidiasis. (6623593)
1983
48
Pulmonary strongyloidiasis. (7063915)
1982
49
Strongyloidiasis and chronic urticaria. (7111108)
1982
50
Transmission of strongyloidiasis by kidney transplant? Disseminated strongyloidiasis in both recipients of kidney allografts from a single cadaver donor. (7026811)
1981

Variations for Strongyloidiasis

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Expression for genes affiliated with Strongyloidiasis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for genes affiliated with Strongyloidiasis

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 54R&D Systems, 30KEGG, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Strongyloidiasis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL5
29.9IL5, IFNG
39.9IFNG, IL5
49.8TGFB1, IL5
5
Show member pathways
9.8IFNG, TGFB1
69.8IFNG, TGFB1
79.5IL5, IFNG, TGFB1
8
Show member pathways
9.5IL5, IFNG, TGFB1
99.4TP53, IFNG, IL5
109.4IGHE, IL5, CCL11
11
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.4IGHE, CD79A, IL5
12
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.3IFNG, TGFB1, TP53
139.3IFNG, TGFB1, TP53
149.3IFNG, TGFB1, TP53
159.3TP53, TGFB1, IFNG
16
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.2IGHE, CCL11, TP53
17
Show member pathways
9.2TGFB1, CCL11, IFNG, IL5
18
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.2IFNG, TGFB1, IL5, CD79A
19
Show member pathways
9.1IL5, TGFB1, CCL11, TP53
20
Show member pathways
8.7IFNG, TP53, TGFB1, IL5, CCL11
21
Show member pathways
8.7TGFB1, IL5, TP53, IFNG, CCL11

Compounds for genes affiliated with Strongyloidiasis

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 51PharmGKB
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Compounds related to Strongyloidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1clarithromycin45 1110.9CCL11, CD79A, IL5
2pirfenidone45 6110.8TGFB1, IFNG, IL5
3gamma globulin459.8CD79A, ALB, IFNG
4con a459.8CD79A, IL5, IFNG
5cetirizine45 29 24 1112.8IGHE, CCL11, IL5
6l-tryptophan51 29 45 24 1113.8ALB, IFNG, IL5
7ketotifen45 1110.7IL5, CCL11, IGHE
8rolipram45 61 2911.7CCL11, IFNG, IL5
9praziquantel45 1110.7IGHE, CD79A, IL5
10ramipril45 1110.7TGFB1, CD79A, ALB
11gm-csf45 2910.7IL5, IFNG, TGFB1
12penicillin459.7IL5, CD79A, IGHE
13montelukast45 51 29 1112.7IGHE, IL5, CCL11
14hhpa459.7ALB, IGHE
15poly(i-c)459.6CCL11, IFNG, IL5
16sulfamethoxazole51 45 1111.6IL5, IGHE, ALB
17glutaraldehyde459.6TGFB1, CD79A, ALB
18pgd2459.5IGHE, CCL11, IL5
19unicap459.5IL5, CCL11, CD79A, IGHE
20sodium cromoglycate459.5CD79A, IL5, CCL11, IGHE
21methylcellulose459.5IL5, IFNG, TGFB1
22salbutamol45 51 29 24 1113.5CD79A, IGHE, CCL11, IL5
23budesonide45 51 1111.5IFNG, IGHE, CCL11, IL5
24fluticasone propionate45 51 61 1112.5IL5, IFNG, IGHE, CCL11
25tarc459.5IGHE, IL5, IFNG, CCL11
26mycophenolate mofetil45 51 1111.4ALB, CD79A, IFNG
27hyaluronic acid45 2410.4TGFB1, CCL11, ALB, CD79A
28il 10459.2IL5, TGFB1, IFNG
29pge2459.2CCL11, CD79A, IL5, TGFB1, IFNG
30allergens459.2IFNG, CCL11, IGHE, IL5, CD79A
31methacholine45 51 1111.1CD79A, IGHE, TGFB1, CCL11, IL5
32sb 20358045 6110.1IL5, IFNG, CCL11, TGFB1, TP53
33butyrate459.1IL5, IFNG, CCL11, TGFB1, TP53
34rantes459.1IFNG, IL5, CCL11, TGFB1
35ivig459.0IL5, CD79A, IFNG, IGHE, ALB
36thymidine45 2410.0CCL11, TGFB1, TP53, IL5, IFNG
37thyroxine45 2410.0IGHE, IL5, CD79A, ALB, TGFB1
38methotrexate51 45 1111.0CD79A, ALB, IL5, IGHE, TGFB1
39vitamin d459.0IL5, IGHE, ALB, TGFB1, CD79A
40heparin45 29 24 1111.9CD79A, ALB, IL5, CCL11, IGHE
41tacrolimus45 51 1110.9TGFB1, ALB, CCL11, CD79A, IFNG, IL5
42actinomycin d458.8TP53, IGHE, TGFB1, CCL11, IFNG
43cyclosporin a45 29 6110.8IL5, CD79A, IFNG, IGHE, CCL11, TGFB1
44prednisolone45 29 1110.8ALB, CD79A, IL5, IFNG, CCL11, IGHE
45dexamethasone45 51 29 1111.7IL5, CD79A, IFNG, TGFB1, CCL11, IGHE
46cycloheximide458.7IFNG, IL5, TGFB1, TP53, IGHE
47indomethacin45 29 61 1111.4CD79A, ALB, IL5, IFNG, CCL11, TGFB1
48histamine45 29 2410.4IGHE, IFNG, CD79A, TGFB1, ALB, IL5
49vegf458.3CCL11, IL5, CD79A, IFNG, TGFB1, TP53
50retinoic acid45 249.3TP53, TGFB1, CCL11, IFNG, IL5, CD79A

GO Terms for genes affiliated with Strongyloidiasis

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Sources:
16Gene Ontology
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Cellular components related to Strongyloidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.2ALB, LGALS3BP, TGFB1
2extracellular spaceGO:0056158.2IL5, TGFB1, LGALS3BP, CCL11, IFNG, ALB
3extracellular regionGO:0055768.0ALB, IGHE, TGFB1, CCL11, IFNG, IL5

Biological processes related to Strongyloidiasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuroblast proliferationGO:0074069.8TGFB1, TP53
2positive regulation of histone deacetylationGO:0310659.8TGFB1, TP53
3positive regulation of cell cycle arrestGO:0711589.7TGFB1, TP53
4response to radiationGO:0093149.7TGFB1, CCL11
5negative regulation of DNA replicationGO:0081569.6TGFB1, TP53
6inflammatory responseGO:0069549.5IL5, CCL11, TGFB1
7protein import into nucleus, translocationGO:0000609.5IFNG, TGFB1, TP53
8extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TGFB1
9cell cycle arrestGO:0070509.4TP53, TGFB1, IFNG
10immune responseGO:0069559.0IGHE, CCL11, IL5, CD7

Molecular functions related to Strongyloidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.2ALB, TGFB1, TP53

Products for genes affiliated with Strongyloidiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Strongyloidiasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet