Aliases & Classifications for Struma Ovarii

MalaCards integrated aliases for Struma Ovarii:

Name: Struma Ovarii 12 51 41 14 69
Struma Ovarii Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2640
MeSH 41 D013330
NCIt 46 C7468
SNOMED-CT 64 189851000 24327009
UMLS 69 C0038478

Summaries for Struma Ovarii

MalaCards based summary : Struma Ovarii, also known as struma ovarii nos, is related to malignant struma ovarii and benign struma ovarii. An important gene associated with Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are MAPK Signaling: Oxidative Stress Pathway and Bladder cancer. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

Related Diseases for Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 malignant struma ovarii 33.4 NKX2-1 RET TG
2 benign struma ovarii 33.3 RET TG TSHR
3 thyroiditis 31.0 RET TG TSHR
4 graves disease 1 30.6 TG TSHR
5 hyperthyroidism 30.3 TG TSHR
6 ovarian germ cell teratoma 30.2 NKX2-1 RET TG
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 TG TSHR
8 hypothyroidism 30.1 NKX2-1 TG TSHR
9 hashimoto thyroiditis 30.0 RET TG TSHR
10 goiter 29.7 NKX2-1 TG TSHR
11 adenoma 29.7 BRAF KRAS RET
12 thyroid cancer, nonmedullary, 1 29.5 BRAF NKX2-1 RET TG TSHR
13 adenocarcinoma 29.4 BRAF KRAS RET
14 papillary thyroid microcarcinoma 29.3 BRAF NKX2-1 TG TSHR
15 papillary carcinoma 29.1 BRAF NKX2-1 RET TG TSHR
16 thyroid cancer, nonmedullary, 2 28.6 BRAF NKX2-1 RET TG TSHR
17 thyroid cancer 28.5 BRAF KRAS NKX2-1 RET TG TSHR
18 differentiated thyroid carcinoma 27.6 BRAF KRAS NKX2-1 RET TG TSHR
19 lymphedema, hereditary, ii 10.6
20 pseudo-meigs syndrome 10.6
21 graves' disease 10.5
22 teratoma 10.5
23 peritonitis 10.4
24 cystadenoma 10.3
25 cervicitis 10.2
26 neonatal hypothyroidism 10.2 TG TSHR
27 malignant teratoma 10.2 NKX2-1 TG
28 endemic goiter 10.2 TG TSHR
29 myxedema 10.2 TG TSHR
30 nontoxic goiter 10.2 TG TSHR
31 subacute thyroiditis 10.2 TG TSHR
32 toxic diffuse goiter 10.2 TG TSHR
33 ovarian cystic teratoma 10.1 NKX2-1 TG
34 ovarian cancer 10.1
35 dermoid cyst 10.1
36 cystic teratoma 10.1
37 endometriosis 10.1
38 exophthalmos 10.1 TG TSHR
39 autoimmune disease of endocrine system 10.1 TG TSHR
40 thyroid gland disease 10.1 TG TSHR
41 hypersensitivity reaction disease 10.0 TG TSHR
42 thyroglossal duct cyst, familial 10.0
43 gonadoblastoma 10.0
44 ovarian cancer 1 10.0
45 episodic pain syndrome, familial, 1 10.0
46 mucinous ovarian cystadenoma 10.0
47 ovarian cystadenoma 10.0
48 cerebritis 10.0
49 sertoli cell tumor 10.0
50 pituitary adenoma 10.0

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to Struma Ovarii

Symptoms & Phenotypes for Struma Ovarii

GenomeRNAi Phenotypes related to Struma Ovarii according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.5 KRAS BRAF
2 Decreased viability GR00106-A-0 9.5 KRAS
3 Decreased viability GR00221-A-1 9.5 RET KRAS
4 Decreased viability GR00221-A-2 9.5 KRAS RET
5 Decreased viability GR00221-A-4 9.5 RET BRAF
6 Decreased viability GR00231-A 9.5 RET
7 Decreased viability GR00301-A 9.5 KRAS RET BRAF
8 Decreased viability GR00381-A-1 9.5 BRAF KRAS

MGI Mouse Phenotypes related to Struma Ovarii:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.88 TSHR KRAS NKX2-1 RET BRAF TG
2 growth/size/body region MP:0005378 9.85 TSHR KRAS NKX2-1 RET BRAF TG
3 homeostasis/metabolism MP:0005376 9.8 TG TSHR KRAS NKX2-1 RET BRAF
4 digestive/alimentary MP:0005381 9.73 BRAF KRAS NKX2-1 RET
5 neoplasm MP:0002006 9.65 TSHR KRAS NKX2-1 RET BRAF
6 nervous system MP:0003631 9.63 TSHR KRAS NKX2-1 RET BRAF TG
7 reproductive system MP:0005389 9.35 TSHR KRAS NKX2-1 RET BRAF
8 respiratory system MP:0005388 8.92 BRAF KRAS NKX2-1 RET

Drugs & Therapeutics for Struma Ovarii

Drugs for Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Struma Ovarii

Cochrane evidence based reviews: struma ovarii

Genetic Tests for Struma Ovarii

Anatomical Context for Struma Ovarii

MalaCards organs/tissues related to Struma Ovarii:

38
Thyroid, Ovary, Liver, Bone, Testes, Pituitary, Thymus

Publications for Struma Ovarii

Articles related to Struma Ovarii:

(show top 50) (show all 326)
# Title Authors Year
1
Precise preoperative diagnosis of struma ovarii with pseudo-Meigs' syndrome mimicking ovarian cancer with the combination of<sup>131</sup>I scintigraphy and<sup>18</sup>F-FDG PET: case report and review of the literature. ( 29391043 )
2018
2
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. ( 29318892 )
2018
3
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
4
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
5
A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma. ( 29223697 )
2017
6
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
7
A Rare Case: Struma Ovarii in a 14-Year-Old Girl. ( 28759301 )
2017
8
Struma Ovarii With Hyperthyroidism. ( 28394842 )
2017
9
Papillary carcinoma in struma ovarii. ( 28251552 )
2017
10
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
11
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
12
Concurrent Intrathyroidal Thyroid Cancer and Thyroid Cancer in Struma Ovarii: A Case Report and Literature Review. ( 29264493 )
2017
13
Struma Ovarii with Pseudo-Meigs' Syndrome and Raised Cancer Antigen-125 Levels Masquerading as an Ovarian Carcinoma Case report and literature review. ( 28690899 )
2017
14
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
15
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
16
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
17
Struma Ovarii With Malignant Transformation and Germline KIT Mutation: A Case Report With Review of the Literature. ( 27258816 )
2016
18
Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Nonlactating Breasts Simultaneously on Postablation (131)I SPECT/CT for Papillary Thyroid Cancer. ( 27994692 )
2016
19
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. ( 27381498 )
2016
20
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
21
Follicular Variant of Papillary Carcinoma Arising in Struma Ovarii. ( 27190936 )
2016
22
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
23
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
24
Incidental diagnosis of struma ovarii through radioiodine whole-body scanning: incremental role of SPECT/CT. ( 27141138 )
2016
25
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
26
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
27
Sonographic and Pathologic Features of Struma Ovarii. ( 26149143 )
2015
28
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. ( 26524822 )
2015
29
Spinal metastasis from struma ovarii: case report and review of the literature. ( 25901242 )
2015
30
Follicular proliferative lesion arising in struma ovarii. ( 26018519 )
2015
31
Struma ovarii: management and follow-up of a rare ovarian tumour. ( 25640097 )
2015
32
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
33
Struma ovarii complicating pregnancy: a case report. ( 26411234 )
2015
34
Struma ovarii accompanied by mature cystic teratoma of the other ovary: A case report and literature review. ( 26137011 )
2015
35
Struma Ovarii in Pregnancy: An Uncommon Cause of Hyperthyroidism. ( 26018691 )
2015
36
Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii. ( 26185700 )
2015
37
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
38
Usefulness of (131)I-SPECT/CT and (18)F-FDG PET/CT in Evaluating Successful (131)I and Retinoic Acid Combined Therapy in a Patient with Metastatic Struma Ovarii. ( 25774238 )
2015
39
Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior. ( 26072948 )
2015
40
Pathology of Struma Ovarii: A Report of 96 Cases. ( 26374222 )
2015
41
METASTATIC RADIOIODINE AVID STRUMA OVARII ASSOCIATED WITH PSEUDO-MEIGS' SYNDROME. ( 26721055 )
2015
42
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. ( 25789033 )
2015
43
Coexistence of Graves' disease and unilateral functioning Struma ovarii: a case report. ( 26530865 )
2015
44
Novel BRAF and KRAS Mutations in Papillary Thyroid Carcinoma Arising in Struma Ovarii. ( 26362194 )
2015
45
Diagnosis of struma ovarii in a patient with papillary thyroid carcinoma--verification via 124I-PET/US fusion. ( 24458572 )
2014
46
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. ( 25474425 )
2014
47
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. ( 25375817 )
2014
48
Coexistence of radioactive iodine-resistant benign struma ovarii with cervical primary papillary cancer of the thyroid: an unusual cause of thyroglobulin-positive radioactive iodine-negative whole-body scans. ( 24934079 )
2014
49
Late Manifestation of Peritoneal strumosis and widespread functioning lesions in the setting of Struma Ovarii simulating "Highly Differentiated Follicular Carcinoma" (HDFCO). ( 25537757 )
2014
50
Struma ovarii with elevated ca-125 levels and ascites mimicking advanced ca ovary. ( 24783110 )
2014

Variations for Struma Ovarii

Expression for Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for Struma Ovarii

GO Terms for Struma Ovarii

Biological processes related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.72 BRAF KRAS RET TG TSHR
2 MAPK cascade GO:0000165 9.54 BRAF KRAS RET
3 axon guidance GO:0007411 9.43 KRAS NKX2-1 RET
4 visual learning GO:0008542 9.4 BRAF KRAS
5 positive regulation of gene expression GO:0010628 9.26 BRAF KRAS NKX2-1 RET
6 epithelial tube branching involved in lung morphogenesis GO:0060441 9.16 KRAS NKX2-1
7 thyroid gland development GO:0030878 8.8 BRAF NKX2-1 TG

Molecular functions related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 8.8 BRAF KRAS RET

Sources for Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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