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MCID: STR021

Struma Ovarii malady
7 genes, 2 tissues, 90 related diseases, 5 phenotypes, 18 articles, clinical trials.

Summaries for Struma Ovarii

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44Wikipedia, 22MalaCards
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Wikipedia: A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains...44 more...

MalaCards: Struma Ovarii, also known as struma ovarii nos (morphologic abnormality), is related to cystic teratoma and hyperthyroidism. An important gene associated with Struma Ovarii is TG (thyroglobulin), and among its related pathways are Autoimmune thyroid disease and Pathway_PA165959425. The compounds propylthiouracil and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid and ovary, and related mouse phenotypes are digestive/alimentary and behavior/neurological.

Aliases & Descriptions for Struma Ovarii

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

struma ovarii 6 8 32 43
struma ovarii nos (morphologic abnormality) 6
struma ovarii (morphologic abnormality) 6

External Ids:

NCIt27 C7468

Related Diseases for Struma Ovarii

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13GeneCards, 14GeneDecks
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Diseases related to struma ovarii by text searches and GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1cystic teratoma30.1NKX2-1, MUC16
2hyperthyroidism29.6NKX2-1, TG, TSHR
3graves' disease29.4TSHR, NKX2-1, TG
4thyroiditis29.2TSHR, HNF1A, MUC16, TG, NKX2-1, RET
5teratoma29.1NKX2-1, MUC16, RET, TG
6papillary thyroid carcinoma29.0NKX2-1, RET, BRAF, HNF1A, TG, TSHR
7thyroid carcinoma28.9BRAF, TSHR, RET, HNF1A, NKX2-1, TG
8carcinoma28.1HNF1A, TG, TSHR, RET, BRAF, NKX2-1
9thyroid cancer26.8NKX2-1, HNF1A, RET, BRAF, TG, TSHR
10adenoma26.1MUC16, HNF1A, TSHR, TG, NKX2-1, BRAF
11bronchogenic cyst13.1NKX2-1, MUC16
12papillary serous adenocarcinoma13.1MUC16, NKX2-1
13subacute thyroiditis13.1TSHR, TG
14toxic diffuse goiter13.1TSHR, TG
15mucinoses13.1TG, TSHR
16papillary adenocarcinoma13.1MUC16, NKX2-1
17ovarian cancer13.1MUC16, TG
18neonatal hypothyroidism13.1TG, TSHR
19nontoxic goiter13.1TG, TSHR
20endemic goiter13.0TG, TSHR
21ovarian mucinous neoplasm13.0NKX2-1, MUC16
22mucinous cystadenocarcinoma13.0NKX2-1, MUC16
23nodular goiter13.0TG, TSHR
24thyroid cancer, follicular13.0TG, TSHR
25thymic carcinoma13.0NKX2-1, TG
26familial medullary thyroid carcinoma12.9TG, RET
27malignant pleural mesothelioma12.9NKX2-1, MUC16
28sacrococcygeal teratoma12.9RET, MUC16
29neuroectodermal endocrine syndrome12.9RET, TG
30follicular adenoma12.9RET, TG
31adult-onset still's disease12.9NKX2-1, TG
32factor vii deficiency12.9TG, MUC16
33thyrotoxicosis12.9TSHR, TG
34peritoneal carcinoma12.9RET, MUC16
35pneumothorax12.8NKX2-1, MUC16
36cystadenocarcinoma12.8MUC16, NKX2-1
37parathyroid adenoma12.7RET, TG
38thyroid agenesis12.7TSHR, NKX2-1, TG
39multinodular goiter12.7NKX2-1, TG, TSHR
40congenital hypothyroidism12.7TSHR, NKX2-1, TG
41thyroid medullary carcinoma12.7TG, RET, NKX2-1
42paraganglioma12.6TG, NKX2-1, RET
43carcinoid syndrome12.6RET, TG, NKX2-1
44myxedema12.6TSHR, MUC16, TG
45mayer-rokitansky-kuster-hauser syndrome12.6TSHR, NKX2-1, TG
46endocervicitis12.6NKX2-1, MUC16
47plasma cell leukemia12.6BRAF, MUC16
48combined immunodeficiency12.5TG, MUC16, TSHR
49severe combined immunodeficiency12.5TG, TSHR, MUC16
50hypothyroidism12.5TSHR, TG, NKX2-1

Graphical network of the top 20 diseases related to struma ovarii:



Graphical network of diseases related to struma ovarii

Clinical Features for Struma Ovarii

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Drugs & Therapeutics for Struma Ovarii

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Struma Ovarii

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Anatomical Context for Struma Ovarii

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22MalaCards
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MalaCards organs/tissues related to struma ovarii:

22
Thyroid, Ovary

Phenotypes for genes affiliated with Struma Ovarii

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25MGI
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MGI Mouse Phenotypes related to struma ovarii:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1digestive/alimentary phenotypeMP:00053818.1RET, BRAF, HNF1A, NKX2-1
2behavior/neurological phenotypeMP:00053867.8NKX2-1, TSHR, HNF1A, BRAF
3endocrine/exocrine gland phenotypeMP:00053797.3RET, BRAF, HNF1A, TSHR, TG, NKX2-1
4growth/size phenotypeMP:00053787.2NKX2-1, TG, TSHR, HNF1A, BRAF, RET
5homeostasis/metabolism phenotypeMP:00053767.1NKX2-1, TG, TSHR, HNF1A, BRAF, RET

Publications for genes affiliated with Struma Ovarii

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35PubMed
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Articles related to struma ovarii:

(show all 18)
idTitleAuthorsYearAffiliating Genes
1RAS mutation-positive follicular variant of papillary thyroid carcinoma arising in a struma ovarii. (19898969)Coyne C.... Nikiforov Y.E.2010RET, BRAF
2Metastatic struma ovarii treated with total thyroidectomy and radioiodine ablation. (19289330)McGill J.F.... Angelos P.2009TG
3Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature. (18334015)Mitrou S.... Kehoe S.2008MUC16
4Cytologic differentiation of struma ovarii from other ovarian neoplasms. (18323278)Daneshbod Y.... Ganjei-Azar P.2008TG, NKX2-1
5Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels. (17365481)Obeidat B.R.... Amarin Z.O.2007MUC16
6A case of concomitant occurrence of struma ovarii and malignant transformation of cystic teratoma. (17652549)Saito N.... Nonaka H.2007NKX2-1
7BRAF in papillary thyroid carcinoma of ovary (struma ovarii). (17721188)Schmidt J.... Nose V.2007BRAF
8Graves' disease and coexisting struma ovarii: struma expression of thyrotropin receptors and the presence of thyrotropin receptor stimulating antibodies. (16910883)Teale E.... Peacey S.R.2006TSHR
9Expression of thyroid transcription factor 1 (TTF-1) in extra thyroidal sites: papillary thyroid carcinoma of branchial cleft cysts and thyroglossal duct cysts and struma ovarii. (17285841)Lanzafame S.... ImmA" A.2006HNF1A, NKX2-1
10Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii. (15790478)Loizzi V.... Selvaggi L.2005MUC16
11Struma ovarii showing clinical characteristics of ovarian malignancy. (16343201)Rim S.Y.... Choi H.S.2005MUC16
12Thyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies. (15080771)Ciccarelli A.... Beckers A.2004TSHR
13Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature. (15350384)Makani S.... Gaba A.R.2004TG
14Coexisting Brenner tumor and struma ovarii in the right ovary: case report and review of the literature. (15482570)Yoshida M.... Minami R.2004TG
15Expression of thyroid transcription factor-1 in strumal carcinoid and struma ovarii: an immunohistochemical study. (12167104)Hamazaki S.... Okada S.2002NKX2-1
16Malignant struma ovarii: recurrence and response to treatment monitored by thyroglobulin levels. (9790800)Rose P.G.... Abdul-Karim F.W.1998TG
17Radiotherapy with iodine-131 in recurrent malignant struma ovarii. (8586108)Brenner W.... Henze E.1996TG
18Struma ovarii simulating ovarian tumors of other types. A report of 30 cases. (7802134)Szyfelbein W.M.... Scully R.E.1995TG

Expression for genes affiliated with Struma Ovarii

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Struma Ovarii

Pathways for genes affiliated with Struma Ovarii

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20KEGG, 34PharmGKB
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Pathways related to struma ovarii according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1Autoimmune thyroid disease209.6TSHR, TG
2Pathway_PA165959425349.1RET, BRAF
3Sorafenib Pharmacodynamics349.0RET, BRAF
4Thyroid cancer208.8RET, BRAF

Compounds for genes affiliated with Struma Ovarii

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32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to struma ovarii according to GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1propylthiouracil32 9 9 11.9TSHR, TG
2125i32 9.8TG, TSHR
3b 72332 9.8MUC16, NKX2-1
4methimazole32 9 9 11.6TSHR, TG
5prednisolone32 9 9 11.5TG, TSHR, MUC16
6sialic acid32 9.4TG, TSHR, MUC16
7depsipeptide32 9.3BRAF, TG
8gold32 9.1BRAF, MUC16, TG
9iodine32 18 10.1BRAF, TSHR, TG
10aspartate32 9.1RET, BRAF, TG
11ribonucleic acid32 9.0RET, TSHR, TG, NKX2-1
12agar32 9.0RET, BRAF, TG
13adenine32 9 18 9 11.9RET, BRAF, TSHR
14valine32 8.9TSHR, BRAF, RET
15sorafenib32 9 9 10.8RET, BRAF
16iodide32 18 9.7NKX2-1, TG, TSHR, BRAF
1712-o-tetradecanoylphorbol 13-acetate32 8.7TSHR, BRAF, RET
18forskolin32 42 9 9 11.7BRAF, TSHR, NKX2-1
19progesterone32 42 9 18 9 12.5BRAF, MUC16, TSHR, NKX2-1
20cyclic amp32 18 9.5NKX2-1, TSHR, BRAF, RET
21arginine32 8.5RET, BRAF, TSHR, TG
22alanine32 8.4RET, BRAF, TSHR, TG
23phenylalanine32 8.4RET, BRAF, HNF1A, TSHR
24sodium32 18 9.3NKX2-1, TG, TSHR, MUC16, BRAF
25sodium iodide32 8.2RET, BRAF, TSHR, TG, NKX2-1
26vegf32 8.1TG, TSHR, MUC16, BRAF, RET
27threonine32 8.1RET, BRAF, MUC16, TSHR, NKX2-1
28glucose32 8.0TSHR, HNF1A, MUC16, BRAF
29oligonucleotide32 7.9NKX2-1, TSHR, HNF1A, BRAF, RET
30paraffin32 7.8NKX2-1, TG, TSHR, MUC16, BRAF, RET
31serine32 7.7NKX2-1, TG, TSHR, MUC16, BRAF, RET
32estrogen32 7.7NKX2-1, TG, TSHR, HNF1A, MUC16, BRAF
33retinoic acid32 42 18 9.6NKX2-1, TG, TSHR, HNF1A, BRAF, RET
34tyrosine32 7.1NKX2-1, TG, TSHR, HNF1A, MUC16, BRAF

GO Terms for genes affiliated with Struma Ovarii

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12Gene Ontology
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Biological processes related to struma ovarii according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:0308789.7TG, NKX2-1

Sources for Struma Ovarii

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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