MCID: STR021
MIFTS: 46

Struma Ovarii malady

Cancer diseases category

Summaries for Struma Ovarii

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66Wikipedia, 34MalaCards
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Wikipedia:66 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

MalaCards: Struma Ovarii, also known as struma ovarii nos, is related to thyroiditis and hyperthyroidism. An important gene associated with Struma Ovarii is TG (thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. The compounds propylthiouracil and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Struma Ovarii

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

struma ovarii 9 11 46 63
struma ovarii nos 9


External Ids:

Disease Ontology9 DOID:2640
MeSH36 D013330
SNOMED-CT59 189851000, 24327009
NCIt41 C7468

Related Diseases for Struma Ovarii

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Struma Ovarii family:

Benign Struma Ovarii Malignant Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7TG, TSHR
2hyperthyroidism31.2TSHR, TG
3teratoma31.1NKX2-1, TG
4graves' disease31.1NKX2-1, TSHR, TG
5papillary thyroid carcinoma31.1TG, BRAF, TSHR, RET
6thyroid cancer30.8NKX2-1, RET, TSHR, BRAF, TG
7hypothyroidism30.7NKX2-1, TSHR, TG
8thyrotoxicosis30.7TSHR, TG
9papillary carcinoma30.6RET, TSHR, MUC16, BRAF, TG, NKX2-1
10adenoma30.5TG, BRAF, TSHR, RET, HNF1A, NKX2-1
11ovarian cancer30.3BRAF, MUC16, NKX2-1
12breast cancer30.2NKX2-1, HNF1A, MUC16
13autoimmune thyroiditis30.2TG, BRAF, TSHR, RET
14goiter30.2TG, BRAF, TSHR, RET, NKX2-1
15malignant struma ovarii11.2
16meigs syndrome10.8
17pseudo-meigs syndrome10.8
18benign struma ovarii10.7
19cystadenoma10.5
20peritonitis10.5
21adenocarcinoma10.4
22cervicitis10.4
23mucinous ovarian cystadenoma10.2
24gonadoblastoma10.2
25cerebritis10.2
26sertoli cell tumor10.2
27cystadenofibroma10.2
28cystic teratoma10.2
29ovarian cystadenoma10.2
30pituitary adenoma10.2
31blindness10.2
32bronchogenic cyst10.1MUC16
33myxedema10.1TSHR, TG
34subacute thyroiditis10.1TSHR, TG
35toxic diffuse goiter10.1TG, TSHR
36papillary adenocarcinoma10.1MUC16, NKX2-1
37endemic goiter10.1TG, TSHR
38nontoxic goiter10.1TSHR, TG
39multinodular goiter10.1TG, TSHR
40abrikosov's tumor10.1NKX2-1, MUC16
41follicular thyroid carcinoma10.1TG, TSHR
42factor vii deficiency10.1TG, MUC16
43malignant pleural mesothelioma10.1MUC16, NKX2-1
44endometrial carcinoma10.0MUC16, BRAF
45malignant mesothelioma10.0NKX2-1, MUC16
46benign mesothelioma10.0NKX2-1, MUC16
47multiple endocrine neoplasia10.0TG, RET
48thyroid agenesis10.0NKX2-1, TSHR, TG
49congenital hypothyroidism10.0NKX2-1, TSHR, TG
50paraganglioma10.0TG, RET

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to struma ovarii

Symptoms for Struma Ovarii

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Drugs & Therapeutics for Struma Ovarii

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Struma Ovarii

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Anatomical Context for Struma Ovarii

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34MalaCards
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MalaCards organs/tissues related to Struma Ovarii:

34
Thyroid, Ovary, Liver, Bone, Thymus, Colon, Breast, Testes, Pituitary

Animal Models for Struma Ovarii or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Struma Ovarii:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0BRAF, RET, HNF1A, NKX2-1
2MP:00053897.7BRAF, TSHR, RET, HNF1A, NKX2-1
3MP:00053867.6NKX2-1, HNF1A, RET, TSHR, BRAF
4MP:00107687.6NKX2-1, HNF1A, RET, TSHR, BRAF
5MP:00036317.5TG, BRAF, TSHR, RET, NKX2-1
6MP:00053797.4NKX2-1, HNF1A, RET, TSHR, BRAF, TG
7MP:00053787.4TG, BRAF, TSHR, RET, HNF1A, NKX2-1
8MP:00053767.4TG, BRAF, TSHR, RET, HNF1A, NKX2-1

Publications for Struma Ovarii

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53PubMed
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Articles related to Struma Ovarii:

(show top 50)    (show all 267)
idTitleAuthorsYear
1
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
2
Tall Cell Variant Papillary Thyroid Carcinoma Arising from Struma Ovarii. (24246339)
2013
3
Incidental finding of struma ovarii. (22770863)
2013
4
Re: coexistence of struma ovarii and serous cystadenoma of the ovary. (23202789)
2013
5
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. (23412916)
2013
6
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: case report and review of the literature. (23806737)
2013
7
Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases. (22181336)
2012
8
Struma ovarii presenting with Hashimoto's thyroiditis: a case report. (22152685)
2011
9
Thyroid-type solid cell nests in struma ovarii. (20034983)
2011
10
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. (21531638)
2011
11
Role of the otolaryngologist in the treatment of struma ovarii. (20013844)
2010
12
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
13
Struma ovarii and peritoneal strumosis with thyrotoxicosis. (19265502)
2009
14
Histologically bland "extremely well differentiated" thyroid carcinomas arising in struma ovarii can recur and metastasize. (19620939)
2009
15
Struma ovarii: CT findings. (18214583)
2008
16
Struma Ovarii with a focus of follicular variant of papillary thyroid cancer: a case report. (18646677)
2008
17
A case of metastatic struma ovarii treated with 131I therapy: focus on preservation of fertility and selected review of the literature. (18584410)
2008
18
Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo-Meigs syndrome may mimic advanced ovarian cancer. (18618418)
2008
19
Papillary carcinoma in struma ovarii: an unusual presentation. (18689908)
2008
20
Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels. (17365481)
2007
21
Malignant struma ovarii: a case report and review of the literature. (15166470)
2004
22
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
23
Struma ovarii: US and CT findings. (14527060)
2003
24
Benign and malignant struma ovarii: report of three cases and review of the literature. (17577264)
2002
25
Struma ovarii: a rare benign pathology which may erroneously suggest malignancy. (11703211)
2001
26
Malignant struma ovarii with thyrotoxicosis. (11520159)
2001
27
Coexistence of Graves' disease and struma ovarii: case report and literature review. (11456276)
2001
28
Cystic struma ovarii: imaging findings. (10864077)
2000
29
Sonographic and clinical characteristics of struma ovarii. (11127011)
2000
30
Struma ovarii mimicking a benign multicystic ovarian tumor: MR imaging in one case. (11392106)
2000
31
Diagnosis and treatment of disseminated struma ovarii with malignant transformation. (9062167)
1997
32
Struma ovarii presenting as acute pseudo-Meigs syndrome with an elevated CA 125 level. (8883774)
1996
33
Struma ovarii simulating ovarian tumors of other types. A report of 30 cases. (7802134)
1995
34
Struma ovarii with pseudo-Meigs' syndrome: report of a case and review of the literature. (7958166)
1994
35
Limitations of CA125 in the preoperative evaluation of a pelvic mass: struma ovarii and ascites. (8216132)
1993
36
Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. (8253550)
1993
37
Metastasis of malignant struma ovarii to the cranial vault during pregnancy. (8413886)
1993
38
Malignant follicular variant of papillary struma ovarii. (2076892)
1990
39
Metastatic malignant struma ovarii presenting as paraparesis from a spinal metastasis. (2738669)
1989
40
Malignant struma ovarii. Light and electron microscopic study. (6821820)
1983
41
Thyroglobulin in struma ovarii. (682610)
1978
42
Ascites and hydrothorax in association with struma ovarii. (943201)
1976
43
Malignant struma ovarii. (1004942)
1976
44
Ovarian teratoma (struma ovarii) (ovarian goiter). (13783814)
1961
45
Struma ovarii: report of one case. (13573525)
1958
46
Struma ovarii; demonstration of both pathologic change and physiologic activity; report of four cases. (13431133)
1957
47
Struma ovarii causing ascites and hydrothorax (Meigs's syndrome). (14808443)
1951
48
Struma ovarii accompanied by thyrectoxicosis. (18857232)
1948
49
Struma Ovarii. (19989482)
1933
50
METASTASIS OF THYROID TISSUE TO ABDOMINAL ORGANS: WITH SPECIAL CASE REPORT OF A STRUMA OVARII METASTASIZING TO THE OMENTUM. (17866434)
1930

Variations for Struma Ovarii

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Expression for genes affiliated with Struma Ovarii

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for genes affiliated with Struma Ovarii

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51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 62Tocris Bioscience
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Pathways related to Struma Ovarii according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TG, TSHR
29.6TG, TSHR
39.5HNF1A, NKX2-1
49.0RET, BRAF
5
Show member pathways
9.0RET, BRAF

Compounds for genes affiliated with Struma Ovarii

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46Novoseek, 3BitterDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Struma Ovarii according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1propylthiouracil46 3 1212.0TSHR, TG
2125i4610.0TSHR, TG
3methimazole46 3 1212.0TSHR, TG
4b 723469.9MUC16, NKX2-1
5hematoxylin469.7NKX2-1, MUC16
6triiodothyronine469.7TSHR, TG
7ganciclovir46 1210.6TG, RET
8depsipeptide469.6BRAF, TG
9prednisolone46 30 1211.5MUC16, TSHR, TG
10sialic acid469.5MUC16, TSHR, TG
11succinate469.5TSHR, RET
12glutamine469.4HNF1A, TSHR, TG
13regorafenib52 1210.4RET, BRAF
14thymidine46 2510.4HNF1A, TSHR, TG
15sorafenib46 52 1211.3BRAF, RET
16creatinine469.3TG, MUC16, HNF1A
17iodine46 2510.3TG, BRAF, TSHR
18gold469.2MUC16, TG, BRAF
19forskolin46 52 1211.1TSHR, BRAF, NKX2-1
20leucine469.1HNF1A, RET, TSHR
21ribonucleic acid469.0NKX2-1, TG, TSHR, RET
22agar469.0RET, TG, BRAF
23cisplatin46 52 62 1212.0MUC16, BRAF, TG
24adenine46 25 1211.0TSHR, RET, BRAF
25testosterone46 62 25 1212.0RET, MUC16, TG
26valine469.0RET, BRAF, TSHR
2712-o-tetradecanoylphorbol 13-acetate468.9RET, BRAF, TSHR
28steroid468.9NKX2-1, MUC16, HNF1A
29iodide46 259.9TSHR, BRAF, TG, NKX2-1
30dexamethasone46 52 30 1211.7HNF1A, MUC16, NKX2-1
31progesterone46 30 62 25 1212.7BRAF, TSHR, MUC16, NKX2-1
32aspartate468.6TG, TSHR, RET, BRAF
33arginine468.6BRAF, TSHR, TG, RET
34phosphatidylinositol468.6TSHR, RET, BRAF
35cyclic amp46 259.6BRAF, TSHR, RET, NKX2-1
36alanine468.6TG, TSHR, BRAF, RET
37glucose468.5HNF1A, TSHR, MUC16, BRAF
38phenylalanine468.5HNF1A, RET, BRAF, TSHR
39lipid468.4BRAF, RET, TSHR, HNF1A
40sodium46 259.3TG, NKX2-1, TSHR, MUC16, BRAF
41sodium iodide468.2TG, BRAF, TSHR, RET, NKX2-1
42vegf468.1TG, RET, MUC16, TSHR, BRAF
43oligonucleotide468.1RET, HNF1A, TSHR, BRAF, NKX2-1
44threonine468.1MUC16, NKX2-1, BRAF, TSHR, RET
45estrogen467.8TG, BRAF, TSHR, HNF1A, NKX2-1, MUC16
46paraffin467.7NKX2-1, RET, TSHR, MUC16, BRAF, TG
47retinoic acid46 258.7TSHR, BRAF, TG, RET, HNF1A, NKX2-1
48serine467.7TSHR, RET, NKX2-1, MUC16, BRAF, TG
49tyrosine467.2BRAF, NKX2-1, HNF1A, RET, TSHR, MUC16

GO Terms for genes affiliated with Struma Ovarii

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17Gene Ontology
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Cellular components related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor complexGO:0432359.4RET, TSHR

Biological processes related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:0308789.4NKX2-1, TG
2positive regulation of transcription, DNA-templatedGO:0458938.9NKX2-1, HNF1A, RET

Molecular functions related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1NKX2-1, HNF1A, RET, TSHR, MUC16, BRAF

Products for genes affiliated with Struma Ovarii

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Sources for Struma Ovarii

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet