MCID: STR021
MIFTS: 46

Struma Ovarii malady

Cancer diseases category
Download this MalaCard

Summaries for Struma Ovarii

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

MalaCards: Struma Ovarii, also known as struma ovarii nos, is related to thyroiditis and hyperthyroidism. An important gene associated with Struma Ovarii is TG (thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. The compounds propylthiouracil and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Struma Ovarii

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

struma ovarii 8 10 45 62
struma ovarii nos 8


External Ids:

Disease Ontology8 DOID:2640
MeSH35 D013330
SNOMED-CT58 189851000, 24327009
NCIt40 C7468

Related Diseases for Struma Ovarii

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Struma Ovarii family:

Benign Struma Ovarii Malignant Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7TG, TSHR
2hyperthyroidism31.2TSHR, TG
3teratoma31.1NKX2-1, TG
4graves' disease31.1NKX2-1, TSHR, TG
5papillary thyroid carcinoma31.1TG, BRAF, TSHR, RET
6thyroid cancer30.8NKX2-1, RET, TSHR, BRAF, TG
7hypothyroidism30.7NKX2-1, TSHR, TG
8thyrotoxicosis30.7TSHR, TG
9papillary carcinoma30.6RET, TSHR, MUC16, BRAF, TG, NKX2-1
10adenoma30.5TG, BRAF, TSHR, RET, HNF1A, NKX2-1
11ovarian cancer30.3BRAF, MUC16, NKX2-1
12breast cancer30.2NKX2-1, HNF1A, MUC16
13autoimmune thyroiditis30.2TG, BRAF, TSHR, RET
14goiter30.2TG, BRAF, TSHR, RET, NKX2-1
15malignant struma ovarii11.2
16meigs syndrome10.8
17pseudo-meigs syndrome10.8
18benign struma ovarii10.7
19cystadenoma10.5
20peritonitis10.5
21adenocarcinoma10.4
22cervicitis10.4
23mucinous ovarian cystadenoma10.2
24gonadoblastoma10.2
25cerebritis10.2
26sertoli cell tumor10.2
27cystadenofibroma10.2
28cystic teratoma10.2
29ovarian cystadenoma10.2
30pituitary adenoma10.2
31blindness10.2
32bronchogenic cyst10.1MUC16
33myxedema10.1TSHR, TG
34subacute thyroiditis10.1TSHR, TG
35toxic diffuse goiter10.1TG, TSHR
36papillary adenocarcinoma10.1MUC16, NKX2-1
37endemic goiter10.1TG, TSHR
38nontoxic goiter10.1TSHR, TG
39multinodular goiter10.1TG, TSHR
40abrikosov's tumor10.1NKX2-1, MUC16
41follicular thyroid carcinoma10.1TG, TSHR
42factor vii deficiency10.1TG, MUC16
43malignant pleural mesothelioma10.1MUC16, NKX2-1
44endometrial carcinoma10.0MUC16, BRAF
45malignant mesothelioma10.0NKX2-1, MUC16
46benign mesothelioma10.0NKX2-1, MUC16
47multiple endocrine neoplasia10.0TG, RET
48thyroid agenesis10.0NKX2-1, TSHR, TG
49congenital hypothyroidism10.0NKX2-1, TSHR, TG
50paraganglioma10.0TG, RET

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to struma ovarii

Symptoms for Struma Ovarii

About this section

Drugs & Therapeutics for Struma Ovarii

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Struma Ovarii

Search NIH Clinical Center for Struma Ovarii

Genetic Tests for Struma Ovarii

About this section

Anatomical Context for Struma Ovarii

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Struma Ovarii:

33
Thyroid, Ovary, Liver, Bone, Thymus, Colon, Breast, Testes, Pituitary

Animal Models for Struma Ovarii or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Struma Ovarii:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0BRAF, RET, HNF1A, NKX2-1
2MP:00053897.7BRAF, TSHR, RET, HNF1A, NKX2-1
3MP:00053867.6NKX2-1, HNF1A, RET, TSHR, BRAF
4MP:00107687.6NKX2-1, HNF1A, RET, TSHR, BRAF
5MP:00036317.5TG, BRAF, TSHR, RET, NKX2-1
6MP:00053797.4NKX2-1, HNF1A, RET, TSHR, BRAF, TG
7MP:00053787.4TG, BRAF, TSHR, RET, HNF1A, NKX2-1
8MP:00053767.4TG, BRAF, TSHR, RET, HNF1A, NKX2-1

Publications for Struma Ovarii

About this section
Sources:
52PubMed
See all sources

Articles related to Struma Ovarii:

(show top 50)    (show all 267)
idTitleAuthorsYear
1
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
2
Tall Cell Variant Papillary Thyroid Carcinoma Arising from Struma Ovarii. (24246339)
2013
3
Incidental finding of struma ovarii. (22770863)
2013
4
Re: coexistence of struma ovarii and serous cystadenoma of the ovary. (23202789)
2013
5
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. (23412916)
2013
6
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: case report and review of the literature. (23806737)
2013
7
Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases. (22181336)
2012
8
Struma ovarii presenting with Hashimoto's thyroiditis: a case report. (22152685)
2011
9
Thyroid-type solid cell nests in struma ovarii. (20034983)
2011
10
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. (21531638)
2011
11
Role of the otolaryngologist in the treatment of struma ovarii. (20013844)
2010
12
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
13
Struma ovarii and peritoneal strumosis with thyrotoxicosis. (19265502)
2009
14
Histologically bland "extremely well differentiated" thyroid carcinomas arising in struma ovarii can recur and metastasize. (19620939)
2009
15
Struma ovarii: CT findings. (18214583)
2008
16
Struma Ovarii with a focus of follicular variant of papillary thyroid cancer: a case report. (18646677)
2008
17
A case of metastatic struma ovarii treated with 131I therapy: focus on preservation of fertility and selected review of the literature. (18584410)
2008
18
Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo-Meigs syndrome may mimic advanced ovarian cancer. (18618418)
2008
19
Papillary carcinoma in struma ovarii: an unusual presentation. (18689908)
2008
20
Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels. (17365481)
2007
21
Malignant struma ovarii: a case report and review of the literature. (15166470)
2004
22
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
23
Struma ovarii: US and CT findings. (14527060)
2003
24
Benign and malignant struma ovarii: report of three cases and review of the literature. (17577264)
2002
25
Struma ovarii: a rare benign pathology which may erroneously suggest malignancy. (11703211)
2001
26
Malignant struma ovarii with thyrotoxicosis. (11520159)
2001
27
Coexistence of Graves' disease and struma ovarii: case report and literature review. (11456276)
2001
28
Cystic struma ovarii: imaging findings. (10864077)
2000
29
Sonographic and clinical characteristics of struma ovarii. (11127011)
2000
30
Struma ovarii mimicking a benign multicystic ovarian tumor: MR imaging in one case. (11392106)
2000
31
Diagnosis and treatment of disseminated struma ovarii with malignant transformation. (9062167)
1997
32
Struma ovarii presenting as acute pseudo-Meigs syndrome with an elevated CA 125 level. (8883774)
1996
33
Struma ovarii simulating ovarian tumors of other types. A report of 30 cases. (7802134)
1995
34
Struma ovarii with pseudo-Meigs' syndrome: report of a case and review of the literature. (7958166)
1994
35
Limitations of CA125 in the preoperative evaluation of a pelvic mass: struma ovarii and ascites. (8216132)
1993
36
Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. (8253550)
1993
37
Metastasis of malignant struma ovarii to the cranial vault during pregnancy. (8413886)
1993
38
Malignant follicular variant of papillary struma ovarii. (2076892)
1990
39
Metastatic malignant struma ovarii presenting as paraparesis from a spinal metastasis. (2738669)
1989
40
Malignant struma ovarii. Light and electron microscopic study. (6821820)
1983
41
Thyroglobulin in struma ovarii. (682610)
1978
42
Ascites and hydrothorax in association with struma ovarii. (943201)
1976
43
Malignant struma ovarii. (1004942)
1976
44
Ovarian teratoma (struma ovarii) (ovarian goiter). (13783814)
1961
45
Struma ovarii: report of one case. (13573525)
1958
46
Struma ovarii; demonstration of both pathologic change and physiologic activity; report of four cases. (13431133)
1957
47
Struma ovarii causing ascites and hydrothorax (Meigs's syndrome). (14808443)
1951
48
Struma ovarii accompanied by thyrectoxicosis. (18857232)
1948
49
Struma Ovarii. (19989482)
1933
50
METASTASIS OF THYROID TISSUE TO ABDOMINAL ORGANS: WITH SPECIAL CASE REPORT OF A STRUMA OVARII METASTASIZING TO THE OMENTUM. (17866434)
1930

Variations for Struma Ovarii

About this section

Expression for genes affiliated with Struma Ovarii

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for genes affiliated with Struma Ovarii

About this section
Sources:
50PathCards, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 61Tocris Bioscience
See all sources

Pathways related to Struma Ovarii according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TG, TSHR
29.6TG, TSHR
39.5HNF1A, NKX2-1
49.0RET, BRAF
5
Show member pathways
9.0RET, BRAF

Compounds for genes affiliated with Struma Ovarii

About this section
Sources:
45Novoseek, 3BitterDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB, 61Tocris Bioscience
See all sources

Compounds related to Struma Ovarii according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1propylthiouracil45 3 1112.0TSHR, TG
2125i4510.0TSHR, TG
3methimazole45 3 1112.0TSHR, TG
4b 723459.9MUC16, NKX2-1
5hematoxylin459.7NKX2-1, MUC16
6triiodothyronine459.7TSHR, TG
7ganciclovir45 1110.6TG, RET
8depsipeptide459.6BRAF, TG
9prednisolone45 29 1111.5MUC16, TSHR, TG
10sialic acid459.5MUC16, TSHR, TG
11succinate459.5TSHR, RET
12glutamine459.4HNF1A, TSHR, TG
13regorafenib51 1110.4RET, BRAF
14thymidine45 2410.4HNF1A, TSHR, TG
15sorafenib45 51 1111.3BRAF, RET
16creatinine459.3TG, MUC16, HNF1A
17iodine45 2410.3TG, BRAF, TSHR
18gold459.2MUC16, TG, BRAF
19forskolin45 51 1111.1TSHR, BRAF, NKX2-1
20leucine459.1HNF1A, RET, TSHR
21ribonucleic acid459.0NKX2-1, TG, TSHR, RET
22agar459.0RET, TG, BRAF
23cisplatin45 51 61 1112.0MUC16, BRAF, TG
24adenine45 24 1111.0TSHR, RET, BRAF
25testosterone45 61 24 1112.0RET, MUC16, TG
26valine459.0RET, BRAF, TSHR
2712-o-tetradecanoylphorbol 13-acetate458.9RET, BRAF, TSHR
28steroid458.9NKX2-1, MUC16, HNF1A
29iodide45 249.9TSHR, BRAF, TG, NKX2-1
30dexamethasone45 51 29 1111.7HNF1A, MUC16, NKX2-1
31progesterone45 29 61 24 1112.7BRAF, TSHR, MUC16, NKX2-1
32aspartate458.6TG, TSHR, RET, BRAF
33arginine458.6BRAF, TSHR, TG, RET
34phosphatidylinositol458.6TSHR, RET, BRAF
35cyclic amp45 249.6BRAF, TSHR, RET, NKX2-1
36alanine458.6TG, TSHR, BRAF, RET
37glucose458.5HNF1A, TSHR, MUC16, BRAF
38phenylalanine458.5HNF1A, RET, BRAF, TSHR
39lipid458.4BRAF, RET, TSHR, HNF1A
40sodium45 249.3TG, NKX2-1, TSHR, MUC16, BRAF
41sodium iodide458.2TG, BRAF, TSHR, RET, NKX2-1
42vegf458.1TG, RET, MUC16, TSHR, BRAF
43oligonucleotide458.1RET, HNF1A, TSHR, BRAF, NKX2-1
44threonine458.1MUC16, NKX2-1, BRAF, TSHR, RET
45estrogen457.8TG, BRAF, TSHR, HNF1A, NKX2-1, MUC16
46paraffin457.7NKX2-1, RET, TSHR, MUC16, BRAF, TG
47retinoic acid45 248.7TSHR, BRAF, TG, RET, HNF1A, NKX2-1
48serine457.7TSHR, RET, NKX2-1, MUC16, BRAF, TG
49tyrosine457.2BRAF, NKX2-1, HNF1A, RET, TSHR, MUC16

GO Terms for genes affiliated with Struma Ovarii

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor complexGO:0432359.4RET, TSHR

Biological processes related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:0308789.4NKX2-1, TG
2positive regulation of transcription, DNA-templatedGO:0458938.9NKX2-1, HNF1A, RET

Molecular functions related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1NKX2-1, HNF1A, RET, TSHR, MUC16, BRAF

Products for genes affiliated with Struma Ovarii

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Struma Ovarii

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet