MCID: STR021
MIFTS: 42

Struma Ovarii malady

Summaries for Struma Ovarii

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63Wikipedia, 32MalaCards
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Wikipedia:63 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

MalaCards: Struma Ovarii, also known as struma ovarii nos, is related to thyroiditis and papillary carcinoma. An important gene associated with Struma Ovarii is TG (thyroglobulin), and among its related pathways are Allograft rejection and FOXA2 and FOXA3 transcription factor networks. The compounds propylthiouracil and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Aliases & Classifications for Struma Ovarii

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

struma ovarii 8 10 44 60
struma ovarii nos 8


External Ids:

Disease Ontology8 DOID:2640
NCIt39 C7468
SNOMED-CT56 24327009, 189851000
MeSH34 D013330

Related Diseases for Struma Ovarii

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17GeneCards, 18GeneDecks
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Diseases in the Struma Ovarii family:

Benign Struma Ovarii Malignant Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.5TG, TSHR
2papillary carcinoma31.2BRAF, NKX2-1, MUC16, RET, TSHR, TG
3papillary thyroid carcinoma31.2BRAF, RET, TSHR, TG
4hyperthyroidism31.0TSHR, TG
5graves' disease31.0NKX2-1, TSHR, TG
6thyroid cancer30.9BRAF, NKX2-1, RET, TSHR, TG
7follicular thyroid carcinoma30.8TG, TSHR
8cystadenoma30.7BRAF
9adenoma30.6HNF1A, BRAF, NKX2-1, RET, TSHR, TG
10hypothyroidism30.6TG, TSHR, NKX2-1
11thyrotoxicosis30.5TG, TSHR
12adenocarcinoma30.4MUC16, NKX2-1, BRAF
13autoimmune thyroiditis30.2TG
14ovarian cancer30.2BRAF, NKX2-1, MUC16
15breast cancer30.2MUC16, BRAF, HNF1A
16goiter30.2BRAF, NKX2-1, RET, TSHR, TG
17malignant struma ovarii11.1
18benign struma ovarii10.8
19peritonitis10.5
20malignant teratoma10.4
21ovary papillary carcinoma10.3
22cervicitis10.3
23stroke, ischemic10.2
24ovarian brenner tumor10.2
25tall cell variant papillary carcinoma10.2
26neuroendocrine carcinoma10.2
27mucinous ovarian cystadenoma10.2
28gonadoblastoma10.2
29cerebritis10.2
30sertoli cell tumor10.2
31ovarian solid teratoma10.2
32cystadenofibroma10.2
33cystic teratoma10.2
34ovarian cystadenoma10.2
35pituitary adenoma10.2
36wilms tumor10.0NKX2-1
37bronchogenic cyst10.0MUC16
38thymus cancer10.0NKX2-1
39kidney cancer10.0HNF1A
40cystadenocarcinoma10.0MUC16
41parathyroid adenoma10.0RET
42teratoma10.0NKX2-1, TG
43diabetes mellitus10.0HNF1A
44hepatitis c10.0HNF1A
45myxedema10.0TG, TSHR
46multinodular goiter10.0TSHR, TG
47familial adenomatous polyposis10.0BRAF
48subacute thyroiditis10.0TG, TSHR
49toxic diffuse goiter10.0TG, TSHR
50obesity10.0HNF1A

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to struma ovarii

Clinical Features for Struma Ovarii

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Drugs & Therapeutics for Struma Ovarii

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Struma Ovarii

Drug clinical trials:

Search ClinicalTrials for Struma Ovarii

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Genetic Tests for Struma Ovarii

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Anatomical Context for Struma Ovarii

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32MalaCards
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MalaCards organs/tissues related to Struma Ovarii:

32
Thyroid, Ovary, Liver, Testes, Bone, Thymus, Breast, Pituitary, Colon

Animal Models for Struma Ovarii or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Struma Ovarii:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0TG, TSHR, RET
2MP:00053818.1HNF1A, BRAF, NKX2-1, RET
3MP:00053897.9HNF1A, BRAF, NKX2-1, RET, TSHR
4MP:00053867.9TSHR, RET, NKX2-1, BRAF, HNF1A
5MP:00053797.7TG, TSHR, RET, NKX2-1, BRAF, HNF1A
6MP:00053787.6HNF1A, BRAF, NKX2-1, RET, TSHR, TG

Publications for Struma Ovarii

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50PubMed
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Articles related to Struma Ovarii:

(show top 50)    (show all 270)
idTitleAuthorsYear
1
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
2
SPECT/CT of Metastatic Struma Ovarii. (23797234)
2014
3
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. (23412916)
2013
4
Imaging struma ovarii by means of 124I-Na PET/CT. (24068641)
2013
5
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. (24217901)
2013
6
Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report. (22682753)
2012
7
Struma ovarii, pseudo-Meigs' syndrome and raised CA125, a rare association. Answer to May e-quid. (22818078)
2012
8
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. (22883659)
2012
9
From struma ovarii to Hashimoto disease--an unusual diagnosis of primary hypothyroidism: case report. (21780949)
2012
10
Thyroid-type solid cell nests in struma ovarii. (20034983)
2011
11
Metastatic malignant struma ovarii. (21598816)
2011
12
Malignant struma ovarii: a case report. (20119594)
2010
13
Lethal, malignant, metastatic struma ovarii. (20825300)
2010
14
Pulmonary metastasis of struma ovarii: a case report. (20706043)
2010
15
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
16
Histologically bland "extremely well differentiated" thyroid carcinomas arising in struma ovarii can recur and metastasize. (19620939)
2009
17
Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. (18753973)
2008
18
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. (17882443)
2008
19
Bilateral struma ovarii: a case mimicking an ovarian neoplasm. (18714585)
2008
20
Imaging of gynecological disease (4): clinical and ultrasound characteristics of struma ovarii. (18636616)
2008
21
Cytologic findings in struma ovarii. (17703442)
2007
22
Coexistence of a round ligament dermoid cyst and struma ovarii in pregnancy. (16412553)
2006
23
Metastatic struma ovarii: the burden of truth. (16714888)
2006
24
Malignant struma ovarii mimic clear cell carcinoma. (14986024)
2005
25
Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii. (15790478)
2005
26
Coexistence of brenner tumor and struma ovarii: case report. (15755015)
2005
27
Struma ovarii: US and CT findings. (14527060)
2003
28
Clear cell struma ovarii. (14636277)
2003
29
Struma ovarii: a rare benign pathology which may erroneously suggest malignancy. (11703211)
2001
30
Struma ovarii: MRI findings. (10721328)
2000
31
Histologic spectrum of struma ovarii. (11876614)
2000
32
Struma ovarii with hyperthyroidism. (11043711)
2000
33
Struma ovarii: MR findings. (9071297)
1997
34
Struma ovarii simulating ovarian tumors of other types. A report of 30 cases. (7802134)
1995
35
Ovarian metastasis from thyroid carcinoma 12 years after partial thyroidectomy mimicking struma ovarii: report of a case. (8005740)
1994
36
Struma ovarii. (7901063)
1993
37
Hyperthyroidism during pregnancy due to coexistence of struma ovarii and Graves' disease. (2349185)
1990
38
Malignant struma ovarii: presentation and management. (2379061)
1990
39
Struma ovarii: hyperthyroidism in a postmenopausal woman. (2831319)
1988
40
Struma ovarii presenting with ascites: a difficult diagnostic problem. (4029203)
1985
41
Struma ovarii with Meigs' syndrome. (6958245)
1982
42
Struma ovarii: report of a case with malignant evolution and of another observed in the course of pregnancy. (7341272)
1980
43
Coexisting Brenner tumor and struma ovarii: case report. (7333303)
1980
44
Radionuclide study of struma ovarii. (4118955)
1973
45
STRUMA OVARII. REPORT OF A POSTPARTUM CASE WITH MASSIVE ASCITES. (14065517)
1963
46
Radioiodine tests in a case of struma ovarii. (13212501)
1954
47
Struma ovarii causing ascites and hydrothorax (Meigs's syndrome). (14808443)
1951
48
Inhibition of a cervical thyroid gland by a functioning struma ovarii. (14841250)
1951
49
Pathology and physiology of struma ovarii. (20279410)
1946
50
Struma ovarii. (21028278)
1946

Genetic Variations for Struma Ovarii

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Expression for genes affiliated with Struma Ovarii

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Struma Ovarii

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Pathways for genes affiliated with Struma Ovarii

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29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 59Tocris Bioscience
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Pathways related to Struma Ovarii according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6TG, TSHR
29.5NKX2-1, HNF1A
3
Hide members
9.3RET, BRAF
49.3RET, BRAF

Compounds for genes affiliated with Struma Ovarii

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44Novoseek, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Struma Ovarii according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.0TG, TSHR
2125i449.9TG, TSHR
3methimazole44 2 1111.9TSHR, TG
4depsipeptide449.7TG, BRAF
5Regorafenib119.7RET, BRAF
6ganciclovir44 1110.6TG, RET
7sorafenib44 49 1111.6RET, BRAF
8b 723449.5NKX2-1, MUC16
9iodide44 2410.5TG, NKX2-1, BRAF
10iodine44 2410.4BRAF, TSHR, TG
11succinate449.4TSHR, RET
12hematoxylin449.4MUC16, NKX2-1
13glutamine449.3TG, TSHR, HNF1A
14agar449.3BRAF, RET, TG
15adenine44 11 2411.2BRAF, RET, TSHR
16forskolin44 49 1111.2BRAF, NKX2-1, TSHR
17valine449.2BRAF, RET, TSHR
18prednisolone44 28 1111.2TG, TSHR, MUC16
19sialic acid449.2TG, TSHR, MUC16
2012-o-tetradecanoylphorbol 13-acetate449.2TSHR, RET, BRAF
21thymidine44 2410.1HNF1A, TSHR, TG
22ribonucleic acid449.1NKX2-1, RET, TSHR, TG
23gold449.0BRAF, MUC16, TG
24leucine449.0TSHR, RET, HNF1A
25aspartate448.9BRAF, RET, TSHR, TG
26arginine448.8TG, TSHR, RET, BRAF
27cyclic amp44 249.8TSHR, RET, NKX2-1, BRAF
28alanine448.8BRAF, RET, TSHR, TG
29cisplatin44 49 59 1111.8BRAF, MUC16, TG
30phenylalanine448.8TSHR, RET, BRAF, HNF1A
31lipid448.5HNF1A, BRAF, RET, TSHR
32sodium iodide448.5TG, TSHR, RET, NKX2-1, BRAF
33progesterone44 59 28 11 2412.5TSHR, MUC16, NKX2-1, BRAF
34creatinine448.5TG, MUC16, HNF1A
35oligonucleotide448.4HNF1A, BRAF, NKX2-1, RET, TSHR
36glucose448.3TSHR, MUC16, BRAF, HNF1A
37sodium44 249.2TG, TSHR, MUC16, NKX2-1, BRAF
38vegf448.1BRAF, MUC16, RET, TSHR, TG
39threonine448.0BRAF, NKX2-1, MUC16, RET, TSHR
40retinoic acid44 249.0HNF1A, BRAF, NKX2-1, RET, TSHR, TG
41paraffin447.7BRAF, NKX2-1, MUC16, RET, TSHR, TG
42estrogen447.7HNF1A, BRAF, NKX2-1, MUC16, TSHR, TG
43serine447.7BRAF, NKX2-1, MUC16, RET, TSHR, TG
44tyrosine447.2HNF1A, BRAF, NKX2-1, MUC16, RET, TSHR

GO Terms for genes affiliated with Struma Ovarii

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16Gene Ontology
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Biological processes related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:0308789.7TG, NKX2-1

Products for genes affiliated with Struma Ovarii

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Sources for Struma Ovarii

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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