MCID: STR021
MIFTS: 42

Struma Ovarii malady

Summaries for Struma Ovarii

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63Wikipedia, 32MalaCards
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Wikipedia:63 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

MalaCards: Struma Ovarii, also known as struma ovarii nos, is related to thyroiditis and papillary carcinoma. An important gene associated with Struma Ovarii is TG (thyroglobulin), and among its related pathways are Allograft rejection and FOXA2 and FOXA3 transcription factor networks. The compounds propylthiouracil and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Aliases & Classifications for Struma Ovarii

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

struma ovarii 8 10 44 60
struma ovarii nos 8


External Ids:

Disease Ontology8 DOID:2640
NCIt39 C7468
SNOMED-CT56 24327009, 189851000
MeSH34 D013330

Related Diseases for Struma Ovarii

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17GeneCards, 18GeneDecks
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Diseases in the Struma Ovarii family:

Benign Struma Ovarii Malignant Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.5TG, TSHR
2papillary carcinoma31.2BRAF, NKX2-1, MUC16, RET, TSHR, TG
3papillary thyroid carcinoma31.2BRAF, RET, TSHR, TG
4hyperthyroidism31.0TSHR, TG
5graves' disease31.0NKX2-1, TSHR, TG
6thyroid cancer30.9BRAF, NKX2-1, RET, TSHR, TG
7follicular thyroid carcinoma30.8TG, TSHR
8cystadenoma30.7BRAF
9adenoma30.6HNF1A, BRAF, NKX2-1, RET, TSHR, TG
10hypothyroidism30.6TG, TSHR, NKX2-1
11thyrotoxicosis30.5TG, TSHR
12adenocarcinoma30.4MUC16, NKX2-1, BRAF
13autoimmune thyroiditis30.2TG
14ovarian cancer30.2BRAF, NKX2-1, MUC16
15breast cancer30.2MUC16, BRAF, HNF1A
16goiter30.2BRAF, NKX2-1, RET, TSHR, TG
17malignant struma ovarii11.1
18benign struma ovarii10.8
19peritonitis10.5
20malignant teratoma10.4
21ovary papillary carcinoma10.3
22cervicitis10.3
23stroke, ischemic10.2
24ovarian brenner tumor10.2
25tall cell variant papillary carcinoma10.2
26neuroendocrine carcinoma10.2
27mucinous ovarian cystadenoma10.2
28gonadoblastoma10.2
29cerebritis10.2
30sertoli cell tumor10.2
31ovarian solid teratoma10.2
32cystadenofibroma10.2
33cystic teratoma10.2
34ovarian cystadenoma10.2
35pituitary adenoma10.2
36wilms tumor10.0NKX2-1
37bronchogenic cyst10.0MUC16
38thymus cancer10.0NKX2-1
39kidney cancer10.0HNF1A
40cystadenocarcinoma10.0MUC16
41parathyroid adenoma10.0RET
42teratoma10.0NKX2-1, TG
43diabetes mellitus10.0HNF1A
44hepatitis c10.0HNF1A
45myxedema10.0TG, TSHR
46multinodular goiter10.0TSHR, TG
47familial adenomatous polyposis10.0BRAF
48subacute thyroiditis10.0TG, TSHR
49toxic diffuse goiter10.0TG, TSHR
50obesity10.0HNF1A

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to struma ovarii

Clinical Features for Struma Ovarii

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Drugs & Therapeutics for Struma Ovarii

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Struma Ovarii

Drug clinical trials:

Search ClinicalTrials for Struma Ovarii

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Genetic Tests for Struma Ovarii

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Anatomical Context for Struma Ovarii

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32MalaCards
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MalaCards organs/tissues related to Struma Ovarii:

32
Thyroid, Ovary, Liver, Bone, Thymus, Colon, Breast, Testes, Pituitary

Animal Models for Struma Ovarii or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Struma Ovarii:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0TG, TSHR, RET
2MP:00053818.1HNF1A, BRAF, NKX2-1, RET
3MP:00053897.9HNF1A, BRAF, NKX2-1, RET, TSHR
4MP:00053867.9TSHR, RET, NKX2-1, BRAF, HNF1A
5MP:00053797.7TG, TSHR, RET, NKX2-1, BRAF, HNF1A
6MP:00053787.6HNF1A, BRAF, NKX2-1, RET, TSHR, TG

Publications for Struma Ovarii

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50PubMed
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Articles related to Struma Ovarii:

(show top 50)    (show all 270)
idTitleAuthorsYear
1
Re: coexistence of struma ovarii and serous cystadenoma of the ovary. (23202789)
2013
2
Delayed treatment of papillary thyroid carcinoma arising from struma ovarii in a patient with history of bilateral salpingo-oophorectomy: a case report. (22068256)
2012
3
Struma ovarii and the thyroid surgeon. (22624934)
2012
4
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. (21531638)
2011
5
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. (21269611)
2011
6
Struma ovarii with papillary thyroid carcinoma. (22315711)
2011
7
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. (21934226)
2011
8
Malignant struma ovarii. (20375218)
2010
9
Struma ovarii and peritoneal strumosis with thyrotoxicosis. (19265502)
2009
10
An unusual cause of pelvic pain: struma ovarii. (19999326)
2009
11
Struma ovarii: CT findings. (18214583)
2008
12
A case of metastatic struma ovarii treated with 131I therapy: focus on preservation of fertility and selected review of the literature. (18584410)
2008
13
Malignant struma ovarii. (18560398)
2008
14
An unusual variant of malignant struma ovarii. (18678124)
2008
15
Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. (18317221)
2008
16
Struma ovarii associated with Meigs syndrome. (17272322)
2007
17
BRAF T1799A mutation occurring in a case of malignant struma ovarii. (17478764)
2007
18
Struma ovarii coincident with Hashimoto's thyroiditis: an unusual cause of hyperthyroidism. (17276434)
2007
19
Abnormal iodine-131 uptake in a benign mucinous ovarian cystadenoma mimicking struma ovarii. (17179812)
2007
20
Struma ovarii in a patient with a history of papillary thyroid carcinoma. (17008292)
2006
21
Graves' disease and coexisting struma ovarii: struma expression of thyrotropin receptors and the presence of thyrotropin receptor stimulating antibodies. (16910883)
2006
22
Expression of thyroid transcription factor 1 (TTF-1) in extra thyroidal sites: papillary thyroid carcinoma of branchial cleft cysts and thyroglossal duct cysts and struma ovarii. (17285841)
2006
23
Asymptomatic struma ovarii: a case report. (16433164)
2005
24
RET/PTC3 rearrangement and thyroid differentiation gene analysis in a struma ovarii fortuitously revealed by elevated serum thyroglobulin concentration. (16405408)
2005
25
Malignant struma ovarii: a case report and review of the literature. (15166470)
2004
26
Papillary thyroid carcinoma of struma ovarii. (14675996)
2004
27
Struma ovarii coexisting with mucinous cystadenoma detected by radioactive iodine. (12972992)
2003
28
Expression of thyroid transcription factor-1 in strumal carcinoid and struma ovarii: an immunohistochemical study. (12167104)
2002
29
Hypothyroidism following struma ovarii tumor resection: a case report. (12118269)
2002
30
Malignant Struma Ovarii: an autopsy report of a clinically unsuspected tumor. (12477455)
2002
31
Coexistence of malignant struma ovarii and Graves' disease. (15251841)
2002
32
Malignant struma ovarii: an unusual presentation. (11575860)
2001
33
Struma ovarii: report of two cases and clinical review. (11471676)
2001
34
Sonographic and clinical characteristics of struma ovarii. (11127011)
2000
35
Struma ovarii mimicking a benign multicystic ovarian tumor: MR imaging in one case. (11392106)
2000
36
Struma ovarii presenting as hyperemesis gravidarum in pregnancy. (15512562)
2000
37
Struma ovarii and hyperthyroidism. (10365682)
1999
38
Histological autoimmune thyroiditis in a struma ovarii. (9813935)
1998
39
Struma ovarii: appearance on MR images. (9922205)
1998
40
Diagnosis and treatment of disseminated struma ovarii with malignant transformation. (9062167)
1997
41
Intraluminal crystalloids in struma ovarii. Immunohistochemical, DNA flow cytometric, and ultrastructural study. (1992980)
1991
42
Malignant struma ovarii. (2910784)
1989
43
Thyroglobulin in struma ovarii. (682610)
1978
44
STUDIES OF THE DISTRIBUTION OF IODINE AND PROTEIN IN A STRUMA OVARII. (14277388)
1965
45
Struma ovarii. (13372276)
1956
46
Struma ovarii with associated fibro-adenoma. (13272139)
1955
47
Struma ovarii with ascites and hydrothorax: case report. (13272991)
1955
48
Struma ovarii: presentation of a case having no other teratoma elements. (13206571)
1954
49
Functioning struma ovarii; report of a case. (14811339)
1951
50
Struma ovarii accompanied by thyrectoxicosis. (18857232)
1948

Genetic Variations for Struma Ovarii

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Expression for genes affiliated with Struma Ovarii

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Struma Ovarii

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Pathways for genes affiliated with Struma Ovarii

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29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 59Tocris Bioscience
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Pathways related to Struma Ovarii according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6TG, TSHR
29.5NKX2-1, HNF1A
3
Hide members
9.3RET, BRAF
49.3RET, BRAF

Compounds for genes affiliated with Struma Ovarii

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44Novoseek, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Struma Ovarii according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.0TG, TSHR
2125i449.9TG, TSHR
3methimazole44 2 1111.9TSHR, TG
4depsipeptide449.7TG, BRAF
5Regorafenib119.7RET, BRAF
6ganciclovir44 1110.6TG, RET
7sorafenib44 49 1111.6RET, BRAF
8b 723449.5NKX2-1, MUC16
9iodide44 2410.5TG, NKX2-1, BRAF
10iodine44 2410.4BRAF, TSHR, TG
11succinate449.4TSHR, RET
12hematoxylin449.4MUC16, NKX2-1
13glutamine449.3TG, TSHR, HNF1A
14agar449.3BRAF, RET, TG
15adenine44 11 2411.2BRAF, RET, TSHR
16forskolin44 49 1111.2BRAF, NKX2-1, TSHR
17valine449.2BRAF, RET, TSHR
18prednisolone44 28 1111.2TG, TSHR, MUC16
19sialic acid449.2TG, TSHR, MUC16
2012-o-tetradecanoylphorbol 13-acetate449.2TSHR, RET, BRAF
21thymidine44 2410.1HNF1A, TSHR, TG
22ribonucleic acid449.1NKX2-1, RET, TSHR, TG
23gold449.0BRAF, MUC16, TG
24leucine449.0TSHR, RET, HNF1A
25aspartate448.9BRAF, RET, TSHR, TG
26arginine448.8TG, TSHR, RET, BRAF
27cyclic amp44 249.8TSHR, RET, NKX2-1, BRAF
28alanine448.8BRAF, RET, TSHR, TG
29cisplatin44 49 59 1111.8BRAF, MUC16, TG
30phenylalanine448.8TSHR, RET, BRAF, HNF1A
31lipid448.5HNF1A, BRAF, RET, TSHR
32sodium iodide448.5TG, TSHR, RET, NKX2-1, BRAF
33progesterone44 59 28 11 2412.5TSHR, MUC16, NKX2-1, BRAF
34creatinine448.5TG, MUC16, HNF1A
35oligonucleotide448.4HNF1A, BRAF, NKX2-1, RET, TSHR
36glucose448.3TSHR, MUC16, BRAF, HNF1A
37sodium44 249.2TG, TSHR, MUC16, NKX2-1, BRAF
38vegf448.1BRAF, MUC16, RET, TSHR, TG
39threonine448.0BRAF, NKX2-1, MUC16, RET, TSHR
40retinoic acid44 249.0HNF1A, BRAF, NKX2-1, RET, TSHR, TG
41paraffin447.7BRAF, NKX2-1, MUC16, RET, TSHR, TG
42estrogen447.7HNF1A, BRAF, NKX2-1, MUC16, TSHR, TG
43serine447.7BRAF, NKX2-1, MUC16, RET, TSHR, TG
44tyrosine447.2HNF1A, BRAF, NKX2-1, MUC16, RET, TSHR

GO Terms for genes affiliated with Struma Ovarii

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16Gene Ontology
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Biological processes related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:0308789.7TG, NKX2-1

Products for genes affiliated with Struma Ovarii

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Sources for Struma Ovarii

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet