MCID: STR021
MIFTS: 47

Struma Ovarii malady

Cancer diseases category
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Summaries for Struma Ovarii

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Wikipedia:65 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

MalaCards based summary: Struma Ovarii, also known as struma ovarii nos, is related to thyroiditis and teratoma. An important gene associated with Struma Ovarii is TG (thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. The compounds propylthiouracil and 125i have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related mouse phenotypes are digestive/alimentary and reproductive system.

Aliases & Classifications for Struma Ovarii

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH
See all sources

Struma Ovarii, Aliases & Descriptions:

Name: Struma Ovarii 8 10 44 62
 
Struma Ovarii Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:2640
NCIt39 C7468
SNOMED-CT57 189851000, 24327009
MeSH34 D013330

Related Diseases for Struma Ovarii

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Diseases in the Struma Ovarii family:

Benign Struma Ovarii Malignant Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.0TG, TSHR
2teratoma31.5NKX2-1, TG
3hyperthyroidism31.3TSHR, TG
4graves' disease31.2NKX2-1, TSHR, TG
5thyrotoxicosis31.0TSHR, TG
6hypothyroidism30.8NKX2-1, TSHR, TG
7papillary thyroid carcinoma30.8TG, BRAF, TSHR, RET
8ovarian cancer30.3BRAF, MUC16, NKX2-1
9breast cancer29.9NKX2-1, HNF1A, MUC16
10autoimmune thyroiditis29.9TG, BRAF, TSHR, RET
11papillary carcinoma29.8RET, TSHR, MUC16, BRAF, TG, NKX2-1
12adenoma29.7TG, BRAF, TSHR, RET, HNF1A, NKX2-1
13goiter29.6TG, BRAF, TSHR, RET, NKX2-1
14malignant struma ovarii11.2
15pseudo-meigs syndrome10.8
16benign struma ovarii10.7
17thyroid cancer10.7
18peritonitis10.6
19cystadenoma10.6
20cervicitis10.5
21bronchogenic cyst10.4MUC16
22adenocarcinoma10.4
23myxedema10.3TSHR, TG
24subacute thyroiditis10.3TSHR, TG
25toxic diffuse goiter10.3TG, TSHR
26papillary adenocarcinoma10.3MUC16, NKX2-1
27mucinous ovarian cystadenoma10.3
28gonadoblastoma10.3
29cerebritis10.3
30sertoli cell tumor10.3
31cystadenofibroma10.3
32cystic teratoma10.3
33ovarian cystadenoma10.3
34pituitary adenoma10.3
35blindness10.3
36endemic goiter10.2TG, TSHR
37nontoxic goiter10.2TSHR, TG
38multinodular goiter10.2TG, TSHR
39abrikosov's tumor10.2NKX2-1, MUC16
40follicular thyroid carcinoma10.2TG, TSHR
41factor vii deficiency10.2TG, MUC16
42malignant pleural mesothelioma10.2MUC16, NKX2-1
43endometrial carcinoma10.2MUC16, BRAF
44malignant mesothelioma10.1NKX2-1, MUC16
45multiple endocrine neoplasia10.1TG, RET
46thyroid agenesis10.1NKX2-1, TSHR, TG
47congenital hypothyroidism10.1NKX2-1, TSHR, TG
48paraganglioma10.1TG, RET
49hemangioma10.0RET, NKX2-1
50lung adenocarcinoma10.0NKX2-1, MUC16, BRAF

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to struma ovarii

Symptoms for Struma Ovarii

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Drugs & Therapeutics for Struma Ovarii

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Drug clinical trials:

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Search NIH Clinical Center for Struma Ovarii

Genetic Tests for Struma Ovarii

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Anatomical Context for Struma Ovarii

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MalaCards organs/tissues related to Struma Ovarii:

32
Thyroid, Ovary, Liver, Bone, Thymus, Colon, Breast, Testes, Pituitary

Animal Models for Struma Ovarii or affiliated genes

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MGI Mouse Phenotypes related to Struma Ovarii:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0BRAF, RET, HNF1A, NKX2-1
2MP:00053897.7BRAF, TSHR, RET, HNF1A, NKX2-1
3MP:00053867.6NKX2-1, HNF1A, RET, TSHR, BRAF
4MP:00107687.6NKX2-1, HNF1A, RET, TSHR, BRAF
5MP:00036317.5TG, BRAF, TSHR, RET, NKX2-1
6MP:00053797.4NKX2-1, HNF1A, RET, TSHR, BRAF, TG
7MP:00053787.4TG, BRAF, TSHR, RET, HNF1A, NKX2-1
8MP:00053767.4TG, BRAF, TSHR, RET, HNF1A, NKX2-1

Publications for Struma Ovarii

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Articles related to Struma Ovarii:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Diffusion-weighted magnetic resonance imaging findings in a patient with struma ovarii. (25272567)
2014
2
Papillary thyroid cancer in a struma ovarii: a report of a rare case. (25402391)
2014
3
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
4
Struma ovarii with elevated ca-125 levels and ascites mimicking advanced ca ovary. (24783110)
2014
5
Tall Cell Variant Papillary Thyroid Carcinoma Arising from Struma Ovarii. (24246339)
2013
6
Incidental finding of struma ovarii. (22770863)
2013
7
Re: coexistence of struma ovarii and serous cystadenoma of the ovary. (23202789)
2013
8
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. (23412916)
2013
9
Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: case report and review of the literature. (23806737)
2013
10
Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases. (22181336)
2012
11
Struma ovarii presenting with Hashimoto's thyroiditis: a case report. (22152685)
2011
12
Thyroid-type solid cell nests in struma ovarii. (20034983)
2011
13
Role of the otolaryngologist in the treatment of struma ovarii. (20013844)
2010
14
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
15
Struma ovarii and peritoneal strumosis with thyrotoxicosis. (19265502)
2009
16
Histologically bland "extremely well differentiated" thyroid carcinomas arising in struma ovarii can recur and metastasize. (19620939)
2009
17
Struma ovarii: CT findings. (18214583)
2008
18
Struma Ovarii with a focus of follicular variant of papillary thyroid cancer: a case report. (18646677)
2008
19
A case of metastatic struma ovarii treated with 131I therapy: focus on preservation of fertility and selected review of the literature. (18584410)
2008
20
Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo-Meigs syndrome may mimic advanced ovarian cancer. (18618418)
2008
21
Papillary carcinoma in struma ovarii: an unusual presentation. (18689908)
2008
22
Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels. (17365481)
2007
23
Malignant struma ovarii: a case report and review of the literature. (15166470)
2004
24
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
25
Struma ovarii: US and CT findings. (14527060)
2003
26
Benign and malignant struma ovarii: report of three cases and review of the literature. (17577264)
2002
27
Struma ovarii: a rare benign pathology which may erroneously suggest malignancy. (11703211)
2001
28
Malignant struma ovarii with thyrotoxicosis. (11520159)
2001
29
Coexistence of Graves' disease and struma ovarii: case report and literature review. (11456276)
2001
30
Cystic struma ovarii: imaging findings. (10864077)
2000
31
Sonographic and clinical characteristics of struma ovarii. (11127011)
2000
32
Struma ovarii presenting as acute pseudo-Meigs syndrome with an elevated CA 125 level. (8883774)
1996
33
Struma ovarii simulating ovarian tumors of other types. A report of 30 cases. (7802134)
1995
34
Struma ovarii with pseudo-Meigs' syndrome: report of a case and review of the literature. (7958166)
1994
35
Limitations of CA125 in the preoperative evaluation of a pelvic mass: struma ovarii and ascites. (8216132)
1993
36
Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. (8253550)
1993
37
Metastasis of malignant struma ovarii to the cranial vault during pregnancy. (8413886)
1993
38
Malignant follicular variant of papillary struma ovarii. (2076892)
1990
39
Metastatic malignant struma ovarii presenting as paraparesis from a spinal metastasis. (2738669)
1989
40
Malignant struma ovarii. Light and electron microscopic study. (6821820)
1983
41
Thyroglobulin in struma ovarii. (682610)
1978
42
Ascites and hydrothorax in association with struma ovarii. (943201)
1976
43
Malignant struma ovarii. (1004942)
1976
44
Ovarian teratoma (struma ovarii) (ovarian goiter). (13783814)
1961
45
Struma ovarii: report of one case. (13573525)
1958
46
Struma ovarii; demonstration of both pathologic change and physiologic activity; report of four cases. (13431133)
1957
47
Struma ovarii causing ascites and hydrothorax (Meigs's syndrome). (14808443)
1951
48
Struma ovarii accompanied by thyrectoxicosis. (18857232)
1948
49
Struma Ovarii. (19989482)
1933
50
METASTASIS OF THYROID TISSUE TO ABDOMINAL ORGANS: WITH SPECIAL CASE REPORT OF A STRUMA OVARII METASTASIZING TO THE OMENTUM. (17866434)
1930

Variations for Struma Ovarii

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Expression for genes affiliated with Struma Ovarii

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Expression patterns in normal tissues for genes affiliated with Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for genes affiliated with Struma Ovarii

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Pathways related to Struma Ovarii according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TSHR, TG
29.6TSHR, TG
39.5HNF1A, NKX2-1
49.0RET, BRAF
5
Show member pathways
9.0RET, BRAF

Compounds for genes affiliated with Struma Ovarii

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Compounds related to Struma Ovarii according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.0TSHR, TG
2125i4410.0TG, TSHR
3methimazole44 2 1112.0TSHR, TG
4b 723449.9NKX2-1, MUC16
5hematoxylin449.7NKX2-1, MUC16
6triiodothyronine449.7TSHR, TG
7ganciclovir44 1110.6RET, TG
8depsipeptide449.6BRAF, TG
9prednisolone44 28 1111.5TSHR, MUC16, TG
10sialic acid449.5TSHR, MUC16, TG
11succinate449.5TSHR, RET
12glutamine449.4TG, TSHR, HNF1A
13regorafenib50 1110.4BRAF, RET
14thymidine44 2410.4TG, TSHR, HNF1A
15sorafenib44 50 1111.3RET, BRAF
16creatinine449.3HNF1A, MUC16, TG
17iodine44 2410.3TSHR, BRAF, TG
18gold449.2TG, BRAF, MUC16
19forskolin44 50 1111.1BRAF, TSHR, NKX2-1
20leucine449.1TSHR, RET, HNF1A
21ribonucleic acid449.0NKX2-1, RET, TSHR, TG
22agar449.0TG, BRAF, RET
23cisplatin44 50 61 1112.0MUC16, BRAF, TG
24adenine44 24 1111.0BRAF, TSHR, RET
25testosterone44 61 24 1112.0TG, MUC16, RET
26valine449.0RET, TSHR, BRAF
2712-o-tetradecanoylphorbol 13-acetate448.9RET, TSHR, BRAF
28steroid448.9NKX2-1, HNF1A, MUC16
29iodide44 249.9TG, BRAF, TSHR, NKX2-1
30dexamethasone44 50 28 1111.7MUC16, HNF1A, NKX2-1
31progesterone44 28 61 24 1112.7BRAF, MUC16, TSHR, NKX2-1
32aspartate448.6RET, TSHR, BRAF, TG
33arginine448.6TG, BRAF, TSHR, RET
34phosphatidylinositol448.6RET, TSHR, BRAF
35cyclic amp44 249.6BRAF, TSHR, RET, NKX2-1
36alanine448.6RET, TSHR, BRAF, TG
37glucose448.5HNF1A, TSHR, MUC16, BRAF
38phenylalanine448.5BRAF, TSHR, RET, HNF1A
39lipid448.4BRAF, TSHR, RET, HNF1A
40sodium44 249.3TG, BRAF, MUC16, TSHR, NKX2-1
41sodium iodide448.2NKX2-1, RET, TSHR, BRAF, TG
42vegf448.1TG, BRAF, MUC16, TSHR, RET
43oligonucleotide448.1BRAF, TSHR, RET, HNF1A, NKX2-1
44threonine448.1BRAF, MUC16, TSHR, RET, NKX2-1
45estrogen447.8TG, BRAF, MUC16, TSHR, HNF1A, NKX2-1
46paraffin447.7TG, BRAF, MUC16, TSHR, RET, NKX2-1
47retinoic acid44 248.7TG, BRAF, TSHR, RET, HNF1A, NKX2-1
48serine447.7TG, BRAF, MUC16, TSHR, RET, NKX2-1
49tyrosine447.2TG, BRAF, MUC16, TSHR, RET, HNF1A

GO Terms for genes affiliated with Struma Ovarii

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Cellular components related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor complexGO:0432359.4RET, TSHR

Biological processes related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:0308789.4NKX2-1, TG
2positive regulation of transcription, DNA-templatedGO:0458938.9NKX2-1, HNF1A, RET

Molecular functions related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1NKX2-1, HNF1A, RET, TSHR, MUC16, BRAF

Products for genes affiliated with Struma Ovarii

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Sources for Struma Ovarii

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet