MCID: STR021
MIFTS: 39

Struma Ovarii malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Struma Ovarii

Aliases & Descriptions for Struma Ovarii:

Name: Struma Ovarii 12 52 42 14 69
Struma Ovarii Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2640
MeSH 42 D013330
NCIt 47 C7468
SNOMED-CT 64 189851000 24327009
UMLS 69 C0038478

Summaries for Struma Ovarii

MalaCards based summary : Struma Ovarii, also known as struma ovarii nos, is related to malignant struma ovarii and benign struma ovarii. An important gene associated with Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Pathways in cancer and MAPK Signaling: Oxidative Stress Pathway. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and bone, and related phenotypes are Decreased viability and endocrine/exocrine gland

Wikipedia : 71 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

Related Diseases for Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
id Related Disease Score Top Affiliating Genes
1 malignant struma ovarii 12.3
2 benign struma ovarii 12.3
3 thyroiditis 10.8
4 meige syndrome 10.5
5 pseudo-meigs syndrome 10.5
6 hyperthyroidism 10.4
7 graves' disease 10.4
8 thyroid cancer 10.4
9 teratoma 10.4
10 peritonitis 10.3
11 papillary carcinoma 10.2
12 adenoma 10.2
13 cystadenoma 10.2
14 chromophil adenoma of the kidney 10.2 NKX2-1 TG
15 neuhauser daly magnelli syndrome 10.2 TG TSHR
16 background diabetic retinopathy 10.2 TG TSHR
17 mesocardia 10.2 TG TSHR
18 krabbe disease 10.2 TG TSHR
19 kidney disease 10.1 NKX2-1 TG
20 conjunctival deposit 10.1 TG TSHR
21 cowden syndrome 3 10.1 RET TG
22 hypothyroidism 10.1
23 cervicitis 10.1
24 endemic goiter 10.1 TG TSHR
25 mixed eosinophil-basophil adenoma 10.1 TG TSHR
26 hypothyroidism, congenital, nongoitrous, 1 10.1 TG TSHR
27 broad ligament malignant neoplasm 10.1 TG TSHR
28 trigonocephaly, nonsyndromic 10.1 BRAF RET
29 acute laryngitis 10.1 TG TSHR
30 bizarre leiomyoma 10.1 NKX2-1 TG
31 denys-drash syndrome 10.1 TG TSHR
32 dermoid cyst 10.0
33 cystic teratoma 10.0
34 adenocarcinoma 10.0
35 hashimoto thyroiditis 10.0
36 urinary tract papillary transitional cell benign neoplasm 10.0 NKX2-1 RET
37 janus kinase-3 deficiency 10.0 TG TSHR
38 acute hemorrhagic encephalitis 10.0 RET TG TSHR
39 infertility 10.0 NKX2-1 RET TG
40 agenesis and aplasia of uterine body 10.0 KRAS NKX2-1
41 autoimmune hemolytic anemia 10.0 RET TG TSHR
42 neutropenia, severe congenital, 5, autosomal recessive 10.0 NKX2-1 RET TG
43 ureter adenocarcinoma 10.0 KRAS NKX2-1
44 bone deterioration disease 10.0 KRAS NKX2-1
45 exudative glomerulonephritis 10.0 KRAS NKX2-1
46 gastrointestinal system benign neoplasm 10.0 KRAS NKX2-1
47 neuronopathy, distal hereditary motor, type viia 10.0 NKX2-1 TG TSHR
48 exanthema subitum 10.0 NKX2-1 TG TSHR
49 commensal bacterial infectious disease 10.0 NKX2-1 TG TSHR
50 aflatoxins-related hepatocellular carcinoma 10.0 NKX2-1 TG TSHR

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to Struma Ovarii

Symptoms & Phenotypes for Struma Ovarii

GenomeRNAi Phenotypes related to Struma Ovarii according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.5 BRAF KRAS
2 Decreased viability GR00106-A-0 9.5 KRAS
3 Decreased viability GR00221-A-1 9.5 KRAS RET
4 Decreased viability GR00221-A-2 9.5 KRAS RET
5 Decreased viability GR00221-A-4 9.5 BRAF RET
6 Decreased viability GR00231-A 9.5 RET
7 Decreased viability GR00301-A 9.5 BRAF KRAS RET
8 Decreased viability GR00381-A-1 9.5 BRAF KRAS

MGI Mouse Phenotypes related to Struma Ovarii:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.88 BRAF KRAS NKX2-1 RET TG TSHR
2 growth/size/body region MP:0005378 9.85 BRAF KRAS NKX2-1 RET TG TSHR
3 homeostasis/metabolism MP:0005376 9.8 BRAF KRAS NKX2-1 RET TG TSHR
4 digestive/alimentary MP:0005381 9.73 BRAF KRAS NKX2-1 RET
5 neoplasm MP:0002006 9.65 BRAF KRAS NKX2-1 RET TSHR
6 nervous system MP:0003631 9.63 BRAF KRAS NKX2-1 RET TG TSHR
7 reproductive system MP:0005389 9.35 BRAF KRAS NKX2-1 RET TSHR
8 respiratory system MP:0005388 8.92 BRAF KRAS NKX2-1 RET

Drugs & Therapeutics for Struma Ovarii

Drugs for Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


id Name Status NCT ID Phase
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Struma Ovarii

Cochrane evidence based reviews: struma ovarii

Genetic Tests for Struma Ovarii

Anatomical Context for Struma Ovarii

MalaCards organs/tissues related to Struma Ovarii:

39
Thyroid, Ovary, Bone, Liver, Breast, Testes, Pituitary

Publications for Struma Ovarii

Articles related to Struma Ovarii:

(show top 50) (show all 313)
id Title Authors Year
1
Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Nonlactating Breasts Simultaneously on Postablation (131)I SPECT/CT for Papillary Thyroid Cancer. ( 27994692 )
2016
2
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
3
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
4
Follicular Variant of Papillary Carcinoma Arising in Struma Ovarii. ( 27190936 )
2016
5
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
6
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
7
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
8
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. ( 27381498 )
2016
9
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
10
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
11
Incidental diagnosis of struma ovarii through radioiodine whole-body scanning: incremental role of SPECT/CT. ( 27141138 )
2016
12
Struma Ovarii With Malignant Transformation and Germline KIT Mutation: A Case Report With Review of the Literature. ( 27258816 )
2016
13
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
14
Struma ovarii: management and follow-up of a rare ovarian tumour. ( 25640097 )
2015
15
Spinal metastasis from struma ovarii: case report and review of the literature. ( 25901242 )
2015
16
Coexistence of Graves' disease and unilateral functioning Struma ovarii: a case report. ( 26530865 )
2015
17
Sonographic and Pathologic Features of Struma Ovarii. ( 26149143 )
2015
18
Follicular proliferative lesion arising in struma ovarii. ( 26018519 )
2015
19
Novel BRAF and KRAS Mutations in Papillary Thyroid Carcinoma Arising in Struma Ovarii. ( 26362194 )
2015
20
Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii. ( 26185700 )
2015
21
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
22
Struma ovarii accompanied by mature cystic teratoma of the other ovary: A case report and literature review. ( 26137011 )
2015
23
Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior. ( 26072948 )
2015
24
Pathology of Struma Ovarii: A Report of 96 Cases. ( 26374222 )
2015
25
Struma Ovarii in Pregnancy: An Uncommon Cause of Hyperthyroidism. ( 26018691 )
2015
26
Struma ovarii complicating pregnancy: a case report. ( 26411234 )
2015
27
Usefulness of (131)I-SPECT/CT and (18)F-FDG PET/CT in Evaluating Successful (131)I and Retinoic Acid Combined Therapy in a Patient with Metastatic Struma Ovarii. ( 25774238 )
2015
28
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. ( 26524822 )
2015
29
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
30
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. ( 25789033 )
2015
31
METASTATIC RADIOIODINE AVID STRUMA OVARII ASSOCIATED WITH PSEUDO-MEIGS' SYNDROME. ( 26721055 )
2015
32
Disseminated struma ovarii containing focal anaplastic carcinoma in peritoneal implants: a case report. ( 25272300 )
2014
33
Struma ovarii with elevated ca-125 levels and ascites mimicking advanced ca ovary. ( 24783110 )
2014
34
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. ( 25474425 )
2014
35
SPECT/CT of Metastatic Struma Ovarii. ( 23797234 )
2014
36
Papillary thyroid cancer in a struma ovarii: a report of a rare case. ( 25402391 )
2014
37
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. ( 25375817 )
2014
38
Coexistence of radioactive iodine-resistant benign struma ovarii with cervical primary papillary cancer of the thyroid: an unusual cause of thyroglobulin-positive radioactive iodine-negative whole-body scans. ( 24934079 )
2014
39
Diagnosis of struma ovarii in a patient with papillary thyroid carcinoma--verification via 124I-PET/US fusion. ( 24458572 )
2014
40
Struma ovarii. A case report. ( 26052205 )
2014
41
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. ( 24152665 )
2014
42
Late Manifestation of Peritoneal strumosis and widespread functioning lesions in the setting of Struma Ovarii simulating "Highly Differentiated Follicular Carcinoma" (HDFCO). ( 25537757 )
2014
43
The lack of consensus in management of malignant struma ovarii. ( 25539066 )
2014
44
Diffusion-weighted magnetic resonance imaging findings in a patient with struma ovarii. ( 25272567 )
2014
45
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. ( 25364407 )
2014
46
Giant struma ovarii. ( 22926802 )
2013
47
Imaging struma ovarii by means of 124I-Na PET/CT. ( 24068641 )
2013
48
Two cases of malignant struma ovarii with metastasis to pelvic bone. ( 23391779 )
2013
49
Papillary carcinoma arising in struma ovarii versus ovarian metastasis from primary thyroid carcinoma: a case report and review of the literature. ( 24421920 )
2013
50
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. ( 23412916 )
2013

Variations for Struma Ovarii

Expression for Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for Struma Ovarii

GO Terms for Struma Ovarii

Biological processes related to Struma Ovarii according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.72 BRAF KRAS RET TG TSHR
2 MAPK cascade GO:0000165 9.54 BRAF KRAS RET
3 axon guidance GO:0007411 9.43 KRAS NKX2-1 RET
4 visual learning GO:0008542 9.4 BRAF KRAS
5 positive regulation of gene expression GO:0010628 9.26 BRAF KRAS NKX2-1 RET
6 epithelial tube branching involved in lung morphogenesis GO:0060441 9.16 KRAS NKX2-1
7 thyroid gland development GO:0030878 8.8 BRAF NKX2-1 TG

Molecular functions related to Struma Ovarii according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 8.8 BRAF KRAS RET

Sources for Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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