MCID: STR021
MIFTS: 39

Struma Ovarii malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Struma Ovarii

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Aliases & Descriptions for Struma Ovarii:

Name: Struma Ovarii 11 50 39 13 68
 
Struma Ovarii Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:2640
MeSH39 D013330
SNOMED-CT62 189851000, 24327009
NCIt45 C7468

Summaries for Struma Ovarii

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Wikipedia:71 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

MalaCards based summary: Struma Ovarii, also known as struma ovarii nos, is related to malignant struma ovarii and benign struma ovarii. An important gene associated with Struma Ovarii is TG (Thyroglobulin), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Human Thyroid Stimulating Hormone (TSH) signaling pathway. Affiliated tissues include thyroid, ovary and breast, and related mouse phenotypes are Decreased viability and digestive/alimentary.

Related Diseases for Struma Ovarii

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Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1malignant struma ovarii12.3
2benign struma ovarii12.3
3thyroiditis10.8
4meige syndrome10.5
5pseudo-meigs syndrome10.5
6hyperthyroidism10.4
7graves' disease10.4
8thyroid cancer10.4
9teratoma10.4
10peritonitis10.3
11papillary carcinoma10.2
12cystadenoma10.2
13adenoma10.2
14chromophil adenoma of the kidney10.2NKX2-1, TG
15neuhauser daly magnelli syndrome10.2TG, TSHR
16background diabetic retinopathy10.2TG, TSHR
17mesocardia10.2TG, TSHR
18krabbe disease10.2TG, TSHR
19kidney disease10.1NKX2-1, TG
20conjunctival deposit10.1TG, TSHR
21cowden syndrome 310.1RET, TG
22hypothyroidism10.1
23cervicitis10.1
24endemic goiter10.1TG, TSHR
25mixed eosinophil-basophil adenoma10.1TG, TSHR
26hypothyroidism, congenital, nongoitrous, 110.1TG, TSHR
27broad ligament malignant neoplasm10.1TG, TSHR
28trigonocephaly, nonsyndromic10.1BRAF, RET
29acute laryngitis10.1TG, TSHR
30bizarre leiomyoma10.1NKX2-1, TG
31denys-drash syndrome10.1TG, TSHR
32hashimoto thyroiditis10.0
33dermoid cyst10.0
34cystic teratoma10.0
35adenocarcinoma10.0
36urinary tract papillary transitional cell benign neoplasm10.0NKX2-1, RET
37janus kinase-3 deficiency10.0TG, TSHR
38acute hemorrhagic encephalitis10.0RET, TG, TSHR
39infertility10.0NKX2-1, RET, TG
40agenesis and aplasia of uterine body10.0KRAS, NKX2-1
41autoimmune hemolytic anemia10.0RET, TG, TSHR
42neutropenia, severe congenital, 5, autosomal recessive10.0NKX2-1, RET, TG
43ureter adenocarcinoma10.0KRAS, NKX2-1
44bone deterioration disease10.0KRAS, NKX2-1
45exudative glomerulonephritis10.0KRAS, NKX2-1
46gastrointestinal system benign neoplasm10.0KRAS, NKX2-1
47neuronopathy, distal hereditary motor, type viia10.0NKX2-1, TG, TSHR
48exanthema subitum10.0NKX2-1, TG, TSHR
49commensal bacterial infectious disease10.0NKX2-1, TG, TSHR
50aflatoxins-related hepatocellular carcinoma10.0NKX2-1, TG, TSHR

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to struma ovarii

Symptoms & Phenotypes for Struma Ovarii

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GenomeRNAi Phenotypes related to Struma Ovarii according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00381-A-19.4BRAF, KRAS, RET

MGI Mouse Phenotypes related to Struma Ovarii according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9BRAF, KRAS, NKX2-1, RET
2MP:00020068.3BRAF, KRAS, NKX2-1, RET, TSHR
3MP:00053898.2BRAF, KRAS, NKX2-1, RET, TSHR
4MP:00053888.1BRAF, KRAS, NKX2-1, RET
5MP:00053798.0BRAF, KRAS, NKX2-1, RET, TG, TSHR
6MP:00053788.0BRAF, KRAS, NKX2-1, RET, TG, TSHR
7MP:00053767.9BRAF, KRAS, NKX2-1, RET, TG, TSHR
8MP:00036317.9BRAF, KRAS, NKX2-1, RET, TG, TSHR

Drugs & Therapeutics for Struma Ovarii

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Drugs for Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones, Hormone Substitutes, and Hormone Antagonists13168
2Hormones14415
3Hormone Antagonists13180

Interventional clinical trials:

idNameStatusNCT IDPhase
1Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer TreatmentCompletedNCT01441154

Search NIH Clinical Center for Struma Ovarii


Cochrane evidence based reviews: struma ovarii

Genetic Tests for Struma Ovarii

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Anatomical Context for Struma Ovarii

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MalaCards organs/tissues related to Struma Ovarii:

36
Thyroid, Ovary, Breast, Liver, Bone, Testes, Pituitary

Publications for Struma Ovarii

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Articles related to Struma Ovarii:

(show top 50)    (show all 313)
idTitleAuthorsYear
1
Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Nonlactating Breasts Simultaneously on Postablation (131)I SPECT/CT for Papillary Thyroid Cancer. (27994692)
2016
2
Treatment and follow-up of malignant struma ovarii: Regarding two cases. (27355004)
2016
3
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. (27224256)
2016
4
Follicular Variant of Papillary Carcinoma Arising in Struma Ovarii. (27190936)
2016
5
A Hormonally Active Malignant Struma Ovarii. (27882257)
2016
6
Sincronous malignant struma ovarii and papillary thyroid carcinoma. (27297016)
2016
7
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. (27843812)
2016
8
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. (27381498)
2016
9
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. (27566096)
2016
10
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. (26791568)
2016
11
Incidental diagnosis of struma ovarii through radioiodine whole-body scanning: incremental role of SPECT/CT. (27141138)
2016
12
Struma Ovarii With Malignant Transformation and Germline KIT Mutation: A Case Report With Review of the Literature. (27258816)
2016
13
Management dilemma of thyroid nodules in patients with malignant struma ovarii. (27563566)
2016
14
Struma ovarii: management and follow-up of a rare ovarian tumour. (25640097)
2015
15
Spinal metastasis from struma ovarii: case report and review of the literature. (25901242)
2015
16
Coexistence of Graves' disease and unilateral functioning Struma ovarii: a case report. (26530865)
2015
17
Sonographic and Pathologic Features of Struma Ovarii. (26149143)
2015
18
Follicular proliferative lesion arising in struma ovarii. (26018519)
2015
19
Novel BRAF and KRAS Mutations in Papillary Thyroid Carcinoma Arising in Struma Ovarii. (26362194)
2015
20
Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii. (26185700)
2015
21
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. (26262453)
2015
22
Struma ovarii accompanied by mature cystic teratoma of the other ovary: A case report and literature review. (26137011)
2015
23
Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior. (26072948)
2015
24
Pathology of Struma Ovarii: A Report of 96 Cases. (26374222)
2015
25
Struma Ovarii in Pregnancy: An Uncommon Cause of Hyperthyroidism. (26018691)
2015
26
Struma ovarii complicating pregnancy: a case report. (26411234)
2015
27
Usefulness of (131)I-SPECT/CT and (18)F-FDG PET/CT in Evaluating Successful (131)I and Retinoic Acid Combined Therapy in a Patient with Metastatic Struma Ovarii. (25774238)
2015
28
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. (26524822)
2015
29
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. (26630220)
2015
30
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. (25789033)
2015
31
METASTATIC RADIOIODINE AVID STRUMA OVARII ASSOCIATED WITH PSEUDO-MEIGS' SYNDROME. (26721055)
2015
32
Disseminated struma ovarii containing focal anaplastic carcinoma in peritoneal implants: a case report. (25272300)
2014
33
Struma ovarii with elevated ca-125 levels and ascites mimicking advanced ca ovary. (24783110)
2014
34
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. (25474425)
2014
35
SPECT/CT of Metastatic Struma Ovarii. (23797234)
2014
36
Papillary thyroid cancer in a struma ovarii: a report of a rare case. (25402391)
2014
37
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. (25375817)
2014
38
Coexistence of radioactive iodine-resistant benign struma ovarii with cervical primary papillary cancer of the thyroid: an unusual cause of thyroglobulin-positive radioactive iodine-negative whole-body scans. (24934079)
2014
39
Diagnosis of struma ovarii in a patient with papillary thyroid carcinoma--verification via 124I-PET/US fusion. (24458572)
2014
40
Struma ovarii. A case report. (26052205)
2014
41
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. (24152665)
2014
42
Late Manifestation of Peritoneal strumosis and widespread functioning lesions in the setting of Struma Ovarii simulating "Highly Differentiated Follicular Carcinoma" (HDFCO). (25537757)
2014
43
The lack of consensus in management of malignant struma ovarii. (25539066)
2014
44
Diffusion-weighted magnetic resonance imaging findings in a patient with struma ovarii. (25272567)
2014
45
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. (25364407)
2014
46
Giant struma ovarii. (22926802)
2013
47
Imaging struma ovarii by means of 124I-Na PET/CT. (24068641)
2013
48
Two cases of malignant struma ovarii with metastasis to pelvic bone. (23391779)
2013
49
Papillary carcinoma arising in struma ovarii versus ovarian metastasis from primary thyroid carcinoma: a case report and review of the literature. (24421920)
2013
50
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. (23412916)
2013

Variations for Struma Ovarii

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Expression for genes affiliated with Struma Ovarii

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Search GEO for disease gene expression data for Struma Ovarii.

Pathways for genes affiliated with Struma Ovarii

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GO Terms for genes affiliated with Struma Ovarii

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Biological processes related to Struma Ovarii according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epithelial tube branching involved in lung morphogenesisGO:006044110.0KRAS, NKX2-1
2axon guidanceGO:00074119.4KRAS, NKX2-1, RET
3thyroid gland developmentGO:00308789.4BRAF, NKX2-1, TG
4MAPK cascadeGO:00001659.3BRAF, KRAS, RET
5visual learningGO:00085429.0BRAF, KRAS
6positive regulation of gene expressionGO:00106288.8BRAF, KRAS, NKX2-1, RET
7signal transductionGO:00071658.1BRAF, KRAS, RET, TG, TSHR

Molecular functions related to Struma Ovarii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:00001668.5BRAF, KRAS, RET

Sources for Struma Ovarii

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet