MCID: STR021
MIFTS: 40

Struma Ovarii malady

Summaries for Struma Ovarii

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64Wikipedia, 33MalaCards
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Wikipedia:64 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

MalaCards: Struma Ovarii, also known as struma ovarii nos, is related to papillary carcinoma and teratoma. An important gene associated with Struma Ovarii is TG (thyroglobulin), and among its related pathways are Allograft rejection and FOXA2 and FOXA3 transcription factor networks. The compounds propylthiouracil and 125i have been mentioned in the context of this disorder. Affiliated tissues include thymus, colon and liver, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Aliases & Classifications for Struma Ovarii

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

struma ovarii 8 10 45 61
struma ovarii nos 8


External Ids:

Disease Ontology8 DOID:2640
NCIt40 C7468
SNOMED-CT57 24327009, 189851000
MeSH35 D013330

Related Diseases for Struma Ovarii

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Struma Ovarii family:

benign struma ovarii malignant struma ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma31.2BRAF, RET, MUC16, TG, TSHR, NKX2-1
2teratoma31.0NKX2-1, TG
3graves' disease31.0NKX2-1, TG, TSHR
4thyroid cancer30.9TG, RET, BRAF, NKX2-1, TSHR
5thyroiditis30.7TG, TSHR
6cystadenoma30.7BRAF
7adenoma30.7TG, HNF1A, BRAF, NKX2-1, RET, TSHR
8thyrotoxicosis30.5TG, TSHR
9adenocarcinoma30.5NKX2-1, BRAF, MUC16
10autoimmune thyroiditis30.3TG
11malignant struma ovarii11.2
12benign struma ovarii10.8
13meigs syndrome10.8
14pseudo-meigs syndrome10.8
15ovary papillary carcinoma10.4
16stroke, ischemic10.2
17ovarian brenner tumor10.2
18tall cell variant papillary carcinoma10.2
19neuroendocrine carcinoma10.2
20mucinous ovarian cystadenoma10.2
21gonadoblastoma10.2
22sertoli cell tumor10.2
23ovarian solid teratoma10.2
24peritoneal carcinoma10.2
25silent pituitary adenoma10.2
26wilms tumor10.0NKX2-1
27bronchogenic cyst10.0MUC16
28thymic carcinoma10.0NKX2-1
29kidney cancer10.0HNF1A
30cystadenocarcinoma10.0MUC16
31parathyroid adenoma10.0RET
32diabetes mellitus10.0HNF1A
33hepatitis c10.0HNF1A
34myxedema10.0TG, TSHR
35familial adenomatous polyposis10.0BRAF
36multinodular goiter10.0TG, TSHR
37cervical adenocarcinoma10.0MUC16
38subacute thyroiditis10.0TSHR, TG
39toxic diffuse goiter10.0TSHR, TG
40papillary adenocarcinoma10.0NKX2-1, MUC16
41nontoxic goiter10.0TG, TSHR
42obesity10.0HNF1A
43endemic goiter10.0TSHR, TG
44paraganglioma10.0RET, TG
45follicular thyroid carcinoma10.0TSHR, TG
46hyperthyroidism10.0TSHR, TG
47abrikosov's tumor10.0MUC16, NKX2-1
48factor vii deficiency10.0TG, MUC16
49malignant pleural mesothelioma10.0MUC16, NKX2-1
50benign mesothelioma10.0NKX2-1, MUC16

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to struma ovarii

Clinical Features for Struma Ovarii

Drugs & Therapeutics for Struma Ovarii

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Struma Ovarii

Drug clinical trials:

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Genetic Tests for Struma Ovarii

Anatomical Context for Struma Ovarii

Sources:
33MalaCards
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MalaCards organs/tissues related to Struma Ovarii:

33
Thymus, Colon, Liver, Thyroid, Breast, Ovary, B cells, Pituitary

Animal Models for Struma Ovarii or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Struma Ovarii

Sources:
51PubMed
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Articles related to Struma Ovarii:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Tall Cell Variant Papillary Thyroid Carcinoma Arising from Struma Ovarii. (24246339)
2013
2
Two cases of malignant struma ovarii with metastasis to pelvic bone. (23391779)
2013
3
Giant struma ovarii. (22926802)
2013
4
Struma ovarii maligna. (23645304)
2013
5
Papillary carcinoma arising in struma ovarii versus ovarian metastasis from primary thyroid carcinoma: a case report and review of the literature. (24421920)
2013
6
Struma ovarii: role of imaging? (24357453)
2013
7
Coexistence of struma ovarii and serous cystadenoma of the ovary. (22317871)
2012
8
Papillary thyroid-type carcinoma arising from struma ovarii. (22787184)
2012
9
Diagnosis of Struma ovarii with medical imaging. (21104246)
2011
10
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. (24371609)
2011
11
Clear cell carcinoma of the ovary mimicking struma ovarii and carcinoid tumor. (20952299)
2011
12
Role of the otolaryngologist in the treatment of struma ovarii. (20013844)
2010
13
Thyroid-type carcinoma of struma ovarii. (20441513)
2010
14
A case of papillary thyroid carcinoma in struma ovarii and review of the literature. (21151690)
2010
15
Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature. (18334015)
2008
16
Clinical characteristics of struma ovarii. (19471561)
2008
17
B-mode and Doppler features of struma ovarii. (18098342)
2008
18
Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. (18317221)
2008
19
Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT. (17452868)
2007
20
A large struma ovarii tumor removed via laparoscopy in a 16-year-old adolescent. (17706482)
2007
21
Malignant struma ovarii: a case report and review of the literature. (17646728)
2007
22
A case of concomitant occurrence of struma ovarii and malignant transformation of cystic teratoma. (17652549)
2007
23
Incidental diagnosis of struma ovarii after thyroidectomy for thyroid cancer: functional imaging studies and follow-up. (16516952)
2006
24
Expression of thyroid transcription factor 1 (TTF-1) in extra thyroidal sites: papillary thyroid carcinoma of branchial cleft cysts and thyroglossal duct cysts and struma ovarii. (17285841)
2006
25
Struma ovarii showing clinical characteristics of ovarian malignancy. (16343201)
2005
26
RET/PTC3 rearrangement and thyroid differentiation gene analysis in a struma ovarii fortuitously revealed by elevated serum thyroglobulin concentration. (16405408)
2005
27
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report. (15262148)
2004
28
Case report: Malignant struma ovarii. (15038677)
2004
29
Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature. (15350384)
2004
30
Cystic struma ovarii presenting with ascites and an elevated CA-125 level. A case report. (12611097)
2003
31
Benign and malignant struma ovarii: report of three cases and review of the literature. (17577264)
2002
32
Conservative therapy for malignant struma ovarii. A case report. (12497687)
2002
33
Malignant struma ovarii: report of a case and review of the literature. (12169779)
2002
34
Malignant Struma Ovarii: an autopsy report of a clinically unsuspected tumor. (12477455)
2002
35
An unusual presentation of struma ovarii mimicking a malignant process. (12423825)
2002
36
Coexistence of malignant struma ovarii and Graves' disease. (15251841)
2002
37
Malignant struma ovarii with thyrotoxicosis. (11520159)
2001
38
MR findings of struma ovarii. (11120414)
2000
39
"Malignant struma ovarii" with peritoneal metastasis: report of two cases. (10949389)
2000
40
A struma ovarii with increased serum basement membrane components: a case report. (11036868)
2000
41
Histological autoimmune thyroiditis in a struma ovarii. (9813935)
1998
42
Struma ovarii: appearance on MR images. (9922205)
1998
43
Radiotherapy with iodine-131 in recurrent malignant struma ovarii. (9091289)
1997
44
Metastasis of malignant struma ovarii to the cranial vault during pregnancy. (8413886)
1993
45
Malignant struma ovarii. Light and electron microscopic study. (6821820)
1983
46
Malignant struma ovarii. A case report and literature review. (6887150)
1983
47
Benign and malignant struma ovarii. (580711)
1978
48
Struma ovarii; demonstration of both pathologic change and physiologic activity; report of four cases. (13431133)
1957
49
Struma ovarii. (14922286)
1952
50
METASTASIS OF THYROID TISSUE TO ABDOMINAL ORGANS: WITH SPECIAL CASE REPORT OF A STRUMA OVARII METASTASIZING TO THE OMENTUM. (17866434)
1930

Genetic Variations for Struma Ovarii

Expression for genes affiliated with Struma Ovarii

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for genes affiliated with Struma Ovarii

Sources:
30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 60Tocris Bioscience
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Pathways related to Struma Ovarii according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6TG, TSHR
29.5NKX2-1, HNF1A
3
Hide members
9.3RET, BRAF
49.3RET, BRAF

Compounds for genes affiliated with Struma Ovarii

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Struma Ovarii according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1propylthiouracil45 2 1112.0TSHR, TG
2125i459.9TG, TSHR
3methimazole45 2 1111.9TSHR, TG
4depsipeptide459.7BRAF, TG
5Regorafenib119.7RET, BRAF
6ganciclovir45 1110.6TG, RET
7sorafenib45 50 1111.6BRAF, RET
8b 723459.5NKX2-1, MUC16
9iodide45 2410.5NKX2-1, BRAF, TG
10iodine45 2410.4TSHR, TG, BRAF
11succinate459.4RET, TSHR
12hematoxylin459.4NKX2-1, MUC16
13glutamine459.3HNF1A, TG, TSHR
14agar459.3BRAF, TG, RET
15adenine45 11 2411.2BRAF, RET, TSHR
16forskolin45 50 1111.2BRAF, NKX2-1, TSHR
17valine459.2BRAF, TSHR, RET
18prednisolone45 29 1111.2TSHR, TG, MUC16
19sialic acid459.2TSHR, TG, MUC16
2012-o-tetradecanoylphorbol 13-acetate459.2BRAF, TSHR, RET
21thymidine45 2410.1HNF1A, TSHR, TG
22ribonucleic acid459.1TG, RET, TSHR, NKX2-1
23gold459.0TG, MUC16, BRAF
24leucine459.0HNF1A, TSHR, RET
25aspartate458.9BRAF, TG, RET, TSHR
26arginine458.8BRAF, RET, TSHR, TG
27cyclic amp45 249.8BRAF, TSHR, RET, NKX2-1
28alanine458.8TG, TSHR, RET, BRAF
29cisplatin45 50 60 1111.8BRAF, TG, MUC16
30phenylalanine458.8RET, BRAF, HNF1A, TSHR
31lipid458.5BRAF, RET, TSHR, HNF1A
32sodium iodide458.5RET, NKX2-1, TSHR, TG, BRAF
33progesterone45 60 29 11 2412.5BRAF, NKX2-1, TSHR, MUC16
34creatinine458.5TG, MUC16, HNF1A
35oligonucleotide458.4TSHR, HNF1A, RET, NKX2-1, BRAF
36glucose458.3HNF1A, TSHR, MUC16, BRAF
37sodium45 249.2NKX2-1, TSHR, BRAF, TG, MUC16
38vegf458.1BRAF, MUC16, RET, TSHR, TG
39threonine458.0MUC16, RET, NKX2-1, TSHR, BRAF
40retinoic acid45 249.0TG, TSHR, RET, NKX2-1, BRAF, HNF1A
41paraffin457.7BRAF, NKX2-1, MUC16, TSHR, RET, TG
42estrogen457.7HNF1A, BRAF, NKX2-1, MUC16, TSHR, TG
43serine457.7TG, TSHR, MUC16, NKX2-1, BRAF, RET
44tyrosine457.2HNF1A, BRAF, MUC16, RET, TSHR, TG

GO Terms for genes affiliated with Struma Ovarii

Sources:
16Gene Ontology
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Biological processes related to Struma Ovarii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:0308789.7TG, NKX2-1

Products for genes affiliated with Struma Ovarii

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Struma Ovarii

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet